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JOURNAL ARTICLE
Patrick S Creisher, Jamie L Perry, Weizhi Zhong, Jun Lei, Kathleen R Mulka, W Hurley Ryan, Ruifeng Zhou, Elgin H Akin, Anguo Liu, Wayne Mitzner, Irina Burd, Andrew Pekosz, Sabra L Klein
SARS-CoV-2 infection during pregnancy is associated with severe COVID-19 and adverse fetal outcomes, but the underlying mechanisms remain poorly understood. Moreover, clinical studies assessing therapeutics against SARS-CoV-2 in pregnancy are limited. To address these gaps, we developed a mouse model of SARS-CoV-2 infection during pregnancy. Outbred CD1 mice were infected at embryonic day (E) 6, E10, or E16 with a mouse adapted SARS-CoV-2 (maSCV2) virus. Outcomes were gestational age-dependent, with greater morbidity, reduced anti-viral immunity, greater viral titers, and impaired fetal growth and neurodevelopment occurring with infection at E16 (3rd trimester-equivalent) than with infection at either E6 (1st trimester-equivalent) or E10 (2nd trimester-equivalent)...
August 15, 2023: Journal of Clinical Investigation
#22
REVIEW
Francis Girvin, Alexander Phan, Sharon Steinberger, Eugene Shostak, Jamie Bessich, Fang Zhou, Alain Borczuk, Geraldine Brusca-Augello, Margaret Goldberg, Joanna Escalon
Tracheobronchial neoplasms are much less common than lung parenchymal neoplasms but can be associated with significant morbidity and mortality. They include a broad differential of both malignant and benign entities, extending far beyond more commonly known pathologic conditions such as squamous cell carcinoma and carcinoid tumor. Airway lesions may be incidental findings at imaging or manifest with symptoms related to airway narrowing or mucosal irritation, invasion of adjacent structures, or distant metastatic disease...
September 2023: Radiographics: a Review Publication of the Radiological Society of North America, Inc
#23
JOURNAL ARTICLE
Eva Niggl, Arjan Bouman, Lauren C Briere, Remco M Hoogenboezem, Ilse Wallaard, Joohyun Park, Jakob Admard, Martina Wilke, Emilio D R O Harris-Mostert, Minetta Elgersma, Jennifer Bain, Meena Balasubramanian, Siddharth Banka, Paul J Benke, Miriam Bertrand, Alyssa E Blesson, Jill Clayton-Smith, Jamie M Ellingford, Madelyn A Gillentine, Dana H Goodloe, Tobias B Haack, Mahim Jain, Ian Krantz, Sharon M Luu, Molly McPheron, Candace L Muss, Sarah E Raible, Nathaniel H Robin, Michael Spiller, Susan Starling, David A Sweetser, Isabelle Thiffault, Francesco Vetrini, Dennis Witt, Emily Woods, Dihong Zhou, Ype Elgersma, Annelot C M van Esbroeck
Heterogeneous nuclear ribonucleoprotein C (HNRNPC) is an essential, ubiquitously abundant protein involved in mRNA processing. Genetic variants in other members of the HNRNP family have been associated with neurodevelopmental disorders. Here, we describe 13 individuals with global developmental delay, intellectual disability, behavioral abnormalities, and subtle facial dysmorphology with heterozygous HNRNPC germline variants. Five of them bear an identical in-frame deletion of nine amino acids in the extreme C terminus...
August 3, 2023: American Journal of Human Genetics
#24
Ghazi Sarwat Syed, Yingqiu Zhou, Jamie Warner, Harish Bhaskaran
No abstract text is available yet for this article.
July 7, 2023: Nature Nanotechnology
#25
JOURNAL ARTICLE
Wei Fu, Jiefu Yin, Huaqiang Cao, Zhongfu Zhou, Junying Zhang, Jingjing Fu, Jamie H Warner, Cheng Wang, Xiaofang Jia, G Neville Greaves, Anthony K Cheetham
Photoluminescence blinking behaviour from single quantum dots under steady illumination is an important but controversial topic. Its occurrence has impeded the use of single quantum dots in bio-imaging. Different mechanisms have been proposed to account for it, although controversial, the most important of which is the non-radiative Auger recombination mechanism whereby photo-charging of quantum dots can lead to the blinking phenomenon. Here, the singly charged trion, which maintains photon emission, including the radiative recombination and non-radiative Auger recombination, leads to fluorescence non-blinking which was observed in photo-charged single graphene quantum dots (GQDs)...
July 3, 2023: Advanced Materials
#26
JOURNAL ARTICLE
Vera Binder, Wantong Li, Muhammad Faisal, Konur Oyman, Donn L Calkins, Jami Shaffer, Emily M Teets, Steven Sher, Andrew Magnotte, Alex Belardo, William Deruelle, T Charles Gregory, Shelley Orwick, Elliott J Hagedorn, Julie R Perlin, Serine Avagyan, Asher Lichtig, Francesca Barrett, Michelle Ammerman, Song Yang, Yi Zhou, William E Carson, Heather R Shive, James S Blachly, Rosa Lapalombella, Leonard I Zon, Bradley W Blaser
Altered hematopoietic stem cell (HSC) fate underlies primary blood disorders but microenvironmental factors controlling this are poorly understood. Genetically barcoded genome editing of synthetic target arrays for lineage tracing (GESTALT) zebrafish were used to screen for factors expressed by the sinusoidal vascular niche that alter the phylogenetic distribution of the HSC pool under native conditions. Dysregulated expression of protein kinase C delta (PKC-δ, encoded by prkcda) increases the number of HSC clones by up to 80% and expands polyclonal populations of immature neutrophil and erythroid precursors...
May 18, 2023: Cell Reports
#27
JOURNAL ARTICLE
Katelyn N Purvis, Hope D Swanson, Kumar Kulldeep Niloy, Yiwang Zhou, John C Panetta, Kristine R Crews, Jamie E Flerlage
PURPOSE: The Stanford V chemotherapy regimen has been used to treat Hodgkin lymphoma (HL) patients since 2002 with excellent cure rates; however, mechlorethamine is no longer available. Bendamustine, a drug structurally similar to alkylating agents and nitrogen mustard, is being substituted for mechlorethamine in combination therapy in a frontline trial for low- and intermediate-risk pediatric HL patients, forming a new backbone of BEABOVP (bendamustine, etoposide, doxorubicin, bleomycin, vincristine, vinblastine, and prednisone)...
July 2023: Cancer Chemotherapy and Pharmacology
#28
JOURNAL ARTICLE
Ghazi Sarwat Syed, Yingqiu Zhou, Jamie Warner, Harish Bhaskaran
Cognitive functions such as learning in mammalian brains have been attributed to the presence of neuronal circuits with feed-forward and feedback topologies. Such networks have interactions within and between neurons that provide excitory and inhibitory modulation effects. In neuromorphic computing, neurons that combine and broadcast both excitory and inhibitory signals using one nanoscale device are still an elusive goal. Here we introduce a type-II, two-dimensional heterojunction-based optomemristive neuron, using a stack of MoS2 , WS2 and graphene that demonstrates both of these effects via optoelectronic charge-trapping mechanisms...
May 4, 2023: Nature Nanotechnology
#29
JOURNAL ARTICLE
Zhenhui Zhong, Yan Xue, C Jake Harris, Ming Wang, Zheng Li, Yunqing Ke, Mukun Liu, Jessica Zhou, Yasaman Jami-Alahmadi, Suhua Feng, James A Wohlschlegel, Steven E Jacobsen
BACKGROUND: The microrchidia (MORC) proteins are a family of evolutionarily conserved GHKL-type ATPases involved in chromatin compaction and gene silencing. Arabidopsis MORC proteins act in the RNA-directed DNA methylation (RdDM) pathway, where they act as molecular tethers to ensure the efficient establishment of RdDM and de novo gene silencing. However, MORC proteins also have RdDM-independent functions although their underlying mechanisms are unknown. RESULTS: In this study, we examine MORC binding regions where RdDM does not occur in order to shed light on the RdDM-independent functions of MORC proteins...
April 26, 2023: Genome Biology
#30
JOURNAL ARTICLE
Chong Yao Ho, Nicole-Ann Lim, Nur Diana Abdul Rahman, Min Chiam, Jamie Xuelian Zhou, Gillian Li Gek Phua, Eng Koon Ong, Crystal Lim, Anupama Roy Chowdhury, Lalit Kumar Radha Krishna
BACKGROUND: Nurturing effective physician-patient relationships is essential to the provision of patient-centred care. Palliative care physicians may apply boundary-crossings or breaches in professional standards to nurture effective physician-patient relationships. Being highly individualized and shaped by the physician's narratives, clinical experience, and contextual considerations, boundary-crossings are susceptible to ethical and professional violations. To better appreciate this concept, we employ the Ring Theory of Personhood (RToP) to map the effects of boundary-crossings on the physician's belief systems...
April 13, 2023: BMC Palliative Care
#31
Patrick S Creisher, Jamie L Perry, Weizhi Zhong, Jun Lei, Kathleen R Mulka, Hurley Ryan, Ruifeng Zhou, Elgin H Akin, Anguo Liu, Wayne Mitzner, Irina Burd, Andrew Pekosz, Sabra L Klein
SARS-CoV-2 infection during pregnancy is associated with severe COVID-19 and adverse fetal outcomes, but the underlying mechanisms remain poorly understood. Moreover, clinical studies assessing therapeutics against SARS-CoV-2 in pregnancy are limited. To address these gaps, we developed a mouse model of SARS-CoV-2 infection during pregnancy. Outbred CD1 mice were infected at embryonic day (E) 6, E10, or E16 with a mouse adapted SARS-CoV-2 (maSCV2) virus. Outcomes were gestational age-dependent with greater morbidity, reduced pulmonary function, reduced anti-viral immunity, greater viral titers, and more adverse fetal outcomes occurring with infection at E16 (3 rd trimester-equivalent) than with infection at either E6 (1 st trimester-equivalent) or E10 (2 nd trimester-equivalent)...
March 23, 2023: bioRxiv
#32
JOURNAL ARTICLE
Ming Wang, Zhenhui Zhong, Javier Gallego-Bartolomé, Suhua Feng, Yuan-Hsin Shih, Mukun Liu, Jessica Zhou, John Curtis Richey, Charmaine Ng, Yasaman Jami-Alahmadi, James Wohlschlegel, Keqiang Wu, Steven E Jacobsen
Arabidopsis telomeric repeat binding factors (TRBs) can bind telomeric DNA sequences to protect telomeres from degradation. TRBs can also recruit Polycomb Repressive Complex 2 (PRC2) to deposit tri-methylation of H3 lysine 27 (H3K27me3) over certain target loci. Here, we demonstrate that TRBs also associate and colocalize with JUMONJI14 (JMJ14) and trigger H3K4me3 demethylation at some loci. The trb1/2/3 triple mutant and the jmj14-1 mutant show an increased level of H3K4me3 over TRB and JMJ14 binding sites, resulting in up-regulation of their target genes...
March 28, 2023: Nature Communications
#33
JOURNAL ARTICLE
Jacquelin Jia Qi Ting, Gillian Li Gek Phua, Daniel Zhihao Hong, Bertrand Kai Yang Lam, Annabelle Jia Sing Lim, Eleanor Jia Xin Chong, Anushka Pisupati, Rei Tan, Jocelyn Yi Huang Yeo, Yi Zhe Koh, Chrystie Wan Ning Quek, Jia Yin Lim, Kuang Teck Tay, Yun Ting Ong, Min Chiam, Jamie Xuelian Zhou, Stephen Mason, Limin Wijaya, Lalit Kumar Radha Krishna
OBJECTIVES: Guiding the development of longitudinal competencies in communication, ethics and professionalism underlines the role of portfolios to capture and evaluate the multiple multisource appraisals and direct personalised support to clinicians. However, a common approach to these combined portfolios continues to elude medical practice. A systematic scoping review is proposed to map portfolio use in training and assessments of ethics, communication and professionalism competencies particularly in its inculcation of new values, beliefs and principles changes attitudes, thinking and practice while nurturing professional identity formation...
March 28, 2023: BMJ Open
#34
JOURNAL ARTICLE
Jamie N Connarn, Han Witjes, Marielle van Zutphen-van Geffen, Rik de Greef, Timothy B Campbell, Kristen Hege, Simon Zhou, Manisha Lamba
Idecabtagene vicleucel (ide-cel; bb2121) is a B-cell maturation antigen-directed chimeric antigen receptor (CAR) T cell therapy approved for treatment of patients with heavily pretreated relapsed and refractory multiple myeloma. This analysis evaluated exposure-response (ER) relationships of ide-cel with key efficacy end points and safety events. Ide-cel exposure data were available from 127 patients treated at target doses of 150, 300, or 450 × 106 CAR+ T cells from the phase II KarMMa study (NCT03361748)...
February 15, 2023: CPT: Pharmacometrics & Systems Pharmacology
#35
JOURNAL ARTICLE
Chrystie Wan Ning Quek, Ryan Rui Song Ong, Ruth Si Man Wong, Sarah Wye Kit Chan, Amanda Kay-Lyn Chok, Grace Shen Shen, Andrea York Tiang Teo, Aiswarya Panda, Neha Burla, Yu An Wong, Ryan Choon Hoe Chee, Caitlin Yuen Ling Loh, Kun Woo Lee, Gabrielle Hui Ning Tan, Ryan Emmanuel Jian Leong, Natalie Song Yi Koh, Yun Ting Ong, Annelissa Mien Chew Chin, Min Chiam, Crystal Lim, Xuelian Jamie Zhou, Simon Yew Kuang Ong, Eng Koon Ong, Lalit Kumar Radha Krishna
BACKGROUND: Concepts of moral distress (MD) among physicians have evolved and extend beyond the notion of psychological distress caused by being in a situation in which one is constrained from acting on what one knows to be right. With many accounts involving complex personal, professional, legal, ethical and moral issues, we propose a review of current understanding of MD among physicians. METHODS: A systematic evidence-based approach guided systematic scoping review is proposed to map the current concepts of MD among physicians published in PubMed, Embase, PsycINFO, Web of Science, SCOPUS, ERIC and Google Scholar databases...
September 2, 2022: BMJ Open
#36
RANDOMIZED CONTROLLED TRIAL
Steven J Russell, Roy W Beck, Edward R Damiano, Firas H El-Khatib, Katrina J Ruedy, Courtney A Balliro, Zoey Li, Peter Calhoun, R Paul Wadwa, Bruce Buckingham, Keren Zhou, Mark Daniels, Philip Raskin, Perrin C White, Jane Lynch, Jeremy Pettus, Irl B Hirsch, Robin Goland, John B Buse, Davida Kruger, Nelly Mauras, Andrew Muir, Janet B McGill, Fran Cogen, Jill Weissberg-Benchell, Jordan S Sherwood, Luz E Castellanos, Mallory A Hillard, Marwa Tuffaha, Melissa S Putman, Mollie Y Sands, Gregory Forlenza, Robert Slover, Laurel H Messer, Erin Cobry, Viral N Shah, Sarit Polsky, Rayhan Lal, Laya Ekhlaspour, Michael S Hughes, Marina Basina, Betul Hatipoglu, Leann Olansky, Amrit Bhangoo, Nikta Forghani, Himala Kashmiri, Francoise Sutton, Abha Choudhary, Jimmy Penn, Rabab Jafri, Maria Rayas, Elia Escaname, Catherine Kerr, Ruby Favela-Prezas, Schafer Boeder, Subbulaxmi Trikudanathan, Kristen M Williams, Natasha Leibel, M Sue Kirkman, Kate Bergamo, Klara R Klein, Jean M Dostou, Sriram Machineni, Laura A Young, Jamie C Diner, Arti Bhan, J Kimberly Jones, Matthew Benson, Keisha Bird, Kimberly Englert, Joe Permuy, Kristina Cossen, Eric Felner, Maamoun Salam, Julie M Silverstein, Samantha Adamson, Andrea Cedeno, Seema Meighan, Andrew Dauber
BACKGROUND: Currently available semiautomated insulin-delivery systems require individualized insulin regimens for the initialization of therapy and meal doses based on carbohydrate counting for routine operation. In contrast, the bionic pancreas is initialized only on the basis of body weight, makes all dose decisions and delivers insulin autonomously, and uses meal announcements without carbohydrate counting. METHODS: In this 13-week, multicenter, randomized trial, we randomly assigned in a 2:1 ratio persons at least 6 years of age with type 1 diabetes either to receive bionic pancreas treatment with insulin aspart or insulin lispro or to receive standard care (defined as any insulin-delivery method with unblinded, real-time continuous glucose monitoring)...
September 29, 2022: New England Journal of Medicine
#37
JOURNAL ARTICLE
Xia Cao, Junki Maruyama, Heyue Zhou, Yanwen Fu, Lisa Kerwin, Colin Powers, Rachel A Sattler, John T Manning, Alok Singh, Reyna Lim, Laura D Healy, Sachi Johnson, Elizabeth Paz Cabral, Donghui Li, Lucy Lu, Arthur Ledesma, Daniel Lee, Susan Richards, Laura Rivero-Nava, Yan Li, Weiqun Shen, Karen Stegman, Benjamin Blair, Shinji Urata, Magumi Kishimoto-Urata, Jamie Ko, Na Du, Kyndal Morais, Kate Lawrence, Ianne Rivera, Chin-I Pai, Damien Bresson, Mark Brunswick, Yanliang Zhang, Henry Ji, Slobodan Paessler, Robert D Allen
Coronavirus disease 2019 (COVID-19) continues to significantly impact the global population, thus countermeasure platforms that enable rapid development of therapeutics against variants of SARS-CoV-2 are essential. We report use of a phage display human antibody library approach to rapidly identify neutralizing antibodies (nAbs) against SARS-CoV-2. We demonstrate the binding and neutralization capability of two nAbs, STI-2020 and STI-5041, against the SARS-CoV-2 WA-1 strain as well as the Alpha and Beta variants...
September 15, 2022: Scientific Reports
#38
JOURNAL ARTICLE
David Lopatto, Anne G Rosenwald, Rebecca C Burgess, Catherine Silver Key, Melanie Van Stry, Matthew Wawersik, Justin R DiAngelo, Amy T Hark, Matthew Skerritt, Anna K Allen, Consuelo Alvarez, Sara Anderson, Cindy Arrigo, Andrew Arsham, Daron Barnard, James E J Bedard, Indrani Bose, John M Braverman, Martin G Burg, Paula Croonquist, Chunguang Du, Sondra Dubowsky, Heather Eisler, Matthew A Escobar, Michael Foulk, Thomas Giarla, Rivka L Glaser, Anya L Goodman, Yuying Gosser, Adam Haberman, Charles Hauser, Shan Hays, Carina E Howell, Jennifer Jemc, Christopher J Jones, Lisa Kadlec, Jacob D Kagey, Kimberly L Keller, Jennifer Kennell, Adam J Kleinschmit, Melissa Kleinschmit, Nighat P Kokan, Olga Ruiz Kopp, Meg M Laakso, Judith Leatherman, Lindsey J Long, Mollie Manier, Juan C Martinez-Cruzado, Luis F Matos, Amie Jo McClellan, Gerard McNeil, Evan Merkhofer, Vida Mingo, Hemlata Mistry, Elizabeth Mitchell, Nathan T Mortimer, Jennifer Leigh Myka, Alexis Nagengast, Paul Overvoorde, Don Paetkau, Leocadia Paliulis, Susan Parrish, Stephanie Toering Peters, Mary Lai Preuss, James V Price, Nicholas A Pullen, Catherine Reinke, Dennis Revie, Srebrenka Robic, Jennifer A Roecklein-Canfield, Michael R Rubin, Takrima Sadikot, Jamie Siders Sanford, Maria Santisteban, Kenneth Saville, Stephanie Schroeder, Christopher D Shaffer, Karim A Sharif, Diane E Sklensky, Chiyedza Small, Sheryl Smith, Rebecca Spokony, Aparna Sreenivasan, Joyce Stamm, Rachel Sterne-Marr, Katherine C Teeter, Justin Thackeray, Jeffrey S Thompson, Norma Velazquez-Ulloa, Cindy Wolfe, James Youngblom, Brian Yowler, Leming Zhou, Janie Brennan, Jeremy Buhler, Wilson Leung, Sarah C R Elgin, Laura K Reed
The Genomics Education Partnership (GEP) engages students in a course-based undergraduate research experience (CURE). To better understand the student attributes that support success in this CURE, we asked students about their attitudes using previously published scales that measure epistemic beliefs about work and science, interest in science, and grit. We found, in general, that the attitudes students bring with them into the classroom contribute to two outcome measures, namely, learning as assessed by a pre- and postquiz and perceived self-reported benefits...
August 2022: Journal of Microbiology & Biology Education: JMBE
#39
JOURNAL ARTICLE
Oskar Wysocki, Cong Zhou, Jacobo Rogado, Prerana Huddar, Rohan Shotton, Ann Tivey, Laurence Albiges, Angelos Angelakas, Dirk Arnold, Theingi Aung, Kathryn Banfill, Mark Baxter, Fabrice Barlesi, Arnaud Bayle, Benjamin Besse, Talvinder Bhogal, Hayley Boyce, Fiona Britton, Antonio Calles, Luis Castelo-Branco, Ellen Copson, Adina Croitoru, Sourbha S Dani, Elena Dickens, Leonie Eastlake, Paul Fitzpatrick, Stephanie Foulon, Henrik Frederiksen, Sarju Ganatra, Spyridon Gennatas, Andreas Glenthøj, Fabio Gomes, Donna M Graham, Christina Hague, Kevin Harrington, Michelle Harrison, Laura Horsley, Richard Hoskins, Zoe Hudson, Lasse H Jakobsen, Nalinie Joharatnam-Hogan, Sam Khan, Umair T Khan, Khurum Khan, Alexandra Lewis, Christophe Massard, Alec Maynard, Hayley McKenzie, Olivier Michielin, Anne C Mosenthal, Berta Obispo, Carlo Palmieri, Rushin Patel, George Pentheroudakis, Solange Peters, Kimberly Rieger-Christ, Timothy Robinson, Emanuela Romano, Michael Rowe, Marina Sekacheva, Roseleen Sheehan, Alexander Stockdale, Anne Thomas, Lance Turtle, David Viñal, Jamie Weaver, Sophie Williams, Caroline Wilson, Caroline Dive, Donal Landers, Timothy Cooksley, André Freitas, Anne C Armstrong, Rebecca J Lee, On Behalf Of The Esmo Co-Care
Patients with cancer have been shown to have increased risk of COVID-19 severity. We previously built and validated the COVID-19 Risk in Oncology Evaluation Tool (CORONET) to predict the likely severity of COVID-19 in patients with active cancer who present to hospital. We assessed the differences in presentation and outcomes of patients with cancer and COVID-19, depending on the wave of the pandemic. We examined differences in features at presentation and outcomes in patients worldwide, depending on the waves of the pandemic: wave 1 D614G (n = 1430), wave 2 Alpha (n = 475), and wave 4 Omicron variant (n = 63, UK and Spain only)...
August 16, 2022: Cancers
#40
JOURNAL ARTICLE
Paul Daly, Dongmei Zhou, Danyu Shen, Yifan Chen, Taiqiang Xue, Siqiao Chen, Qimeng Zhang, Jinfeng Zhang, Jamie McGowan, Feng Cai, Guan Pang, Nan Wang, Taha Majid Mahmood Sheikh, Sheng Deng, Jingjing Li, Hüseyin Okan Soykam, Irem Kara, David A Fitzpatrick, Irina S Druzhinina, Günseli Bayram Akcapinar, Lihui Wei
The Pythium (Peronosporales, Oomycota) genus includes devastating plant pathogens that cause widespread diseases and severe crop losses. Here, we have uncovered a far greater arsenal of virulence factor-related genes in the necrotrophic Pythium myriotylum than in other Pythium plant pathogens. The genome of a plant-virulent P. myriotylum strain (~70 Mb and 19,878 genes) isolated from a diseased rhizome of ginger (Zingiber officinale) encodes the largest repertoire of putative effectors, proteases, and plant cell wall-degrading enzymes (PCWDEs) among the studied species...
August 10, 2022: Microbiology Spectrum
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