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Jamie zhou

Tarsis F Brust, Jenny Morgenweck, Susy A Kim, Jamie H Rose, Jason L Locke, Cullen L Schmid, Lei Zhou, Edward L Stahl, Michael D Cameron, Sarah M Scarry, Jeffrey Aubé, Sara R Jones, Thomas J Martin, Laura M Bohn
Agonists targeting the kappa opioid receptor (KOR) have been promising therapeutic candidates because of their efficacy for treating intractable itch and relieving pain. Unlike typical opioid narcotics, KOR agonists do not produce euphoria or lead to respiratory suppression or overdose. However, they do produce dysphoria and sedation, side effects that have precluded their clinical development as therapeutics. KOR signaling can be fine-tuned to preferentially activate certain pathways over others, such that agonists can bias signaling so that the receptor signals through G proteins rather than other effectors such as βarrestin2...
November 29, 2016: Science Signaling
Tiger Zhou, Emmanuelle Souzeau, Shiwani Sharma, Owen M Siggs, Ivan Goldberg, Paul R Healey, Stuart Graham, Alex W Hewitt, David A Mackey, Robert J Casson, John Landers, Richard Mills, Jonathan Ellis, Paul Leo, Matthew A Brown, Stuart MacGregor, Kathryn P Burdon, Jamie E Craig
BACKGROUND: Genome-wide association studies (GWAS) have identified association of common alleles with primary open-angle glaucoma (POAG) and its quantitative endophenotypes near numerous genes. This study aims to determine whether rare pathogenic variants in these disease-associated genes contribute to POAG. METHODS: Participants fulfilled strict inclusion criteria of advanced POAG at a young age of diagnosis. Myocilin mutation carriers were excluded using direct sequencing...
November 2016: Molecular Genetics & Genomic Medicine
Haijie Tan, Ye Fan, Yingqiu Zhou, Qu Chen, Wenshuo Xu, Jamie H Warner
In this report, graphene (Gr) is used as a 2D electrode and monolayer WS2 as the active semiconductor in ultrathin photodetector devices. All of the 2D materials are grown by chemical vapor deposition (CVD) and thus pose as a viable route to scalability. The monolayer thickness of both electrode and semiconductor gives these photodetectors ∼2 nm thickness. We show that graphene is different to conventional metal (Au) electrodes due to the finite density of states from the Dirac cones of the valence and conduction bands, which enables the photoresponsivity to be modulated by electrostatic gating and light input control...
August 23, 2016: ACS Nano
Ranjodh Singh, Zhiping Zhou, Jamie Tisnado, Sofia Haque, Kyung K Peck, Robert J Young, Apostolos John Tsiouris, Sunitha B Thakur, Mark M Souweidane
OBJECTIVE Accurately determining diffuse intrinsic pontine glioma (DIPG) tumor volume is clinically important. The aims of the current study were to 1) measure DIPG volumes using methods that require different degrees of subjective judgment; and 2) evaluate interobserver agreement of measurements made using these methods. METHODS Eight patients from a Phase I clinical trial testing convection-enhanced delivery (CED) of a therapeutic antibody were included in the study. Pre-CED, post-radiation therapy axial T2-weighted images were analyzed using 2 methods requiring high degrees of subjective judgment (picture archiving and communication system [PACS] polygon and Volume Viewer auto-contour methods) and 1 method requiring a low degree of subjective judgment (k-means clustering segmentation) to determine tumor volumes...
July 8, 2016: Journal of Neurosurgery. Pediatrics
Soo Khai Ng, Kathryn P Burdon, Jude T Fitzgerald, Tiger Zhou, Rhys Fogarty, Emmanuelle Souzeau, John Landers, Richard A Mills, Robert J Casson, Bronwyn Ridge, Stuart L Graham, Alex W Hewitt, David A Mackey, Paul R Healey, Jie Jin Wang, Paul Mitchell, Stuart MacGregor, Jamie E Craig
PURPOSE: Many genome-wide association studies have identified common single nucleotide polymorphisms (SNPs) at the 9p21 glaucoma locus (CDKN2B/CDKN2B-AS1) to be significantly associated with primary open-angle glaucoma (POAG), with association being stronger in normal tension glaucoma (NTG) and advanced glaucoma. We aimed to determine whether any observed differences in genetic association at the 9p21 locus are influenced by sex. METHODS: Sex was assessed as a risk factor for POAG for 2241 glaucoma participants from the Australian and New Zealand Registry of Advanced Glaucoma, the Glaucoma Inheritance Study in Tasmania, and the Flinders Medical Centre...
June 1, 2016: Investigative Ophthalmology & Visual Science
Zhiwei Wang, Tianqi Liao, Zhongkai Zhou, Yuyang Wang, Yongjia Diao, Padraig Strappe, Paul Prenzler, Jamie Ayton, Chris Blanchard
To study the mechanism underlying the liver damage induced by deep-fried oil (DO) consumption and the beneficial effects from resistant starch (RS) supplement, differential gene expression and pathway network were analyzed based on RNA sequencing data from rats. The up/down regulated genes and corresponding signaling pathways were used to construct a novel local gene network (LGN). The topology of the network showed characteristics of small-world network, with some pathways demonstrating a high degree. Some changes in genes led to a larger probability occurrence of disease or infection with DO intake...
September 6, 2016: Toxicology Letters
Zhengyu He, Xiaochen Wang, Wenshuo Xu, Yingqiu Zhou, Yuewen Sheng, Youmin Rong, Jason M Smith, Jamie H Warner
Understanding the stability of monolayer transition metal dichalcogenides in atmospheric conditions has important consequences for their handling, life-span, and utilization in applications. We show that cryogenic photoluminescence spectroscopy (PL) is a highly sensitive technique to the detection of oxidation induced degradation of monolayer tungsten disulfide (WS2) caused by exposure to ambient conditions. Although long-term exposure to atmospheric conditions causes massive degradation from oxidation that is optically visible, short-term exposure produces no obvious changes to the PL or Raman spectra measured at either room temperature or even cryogenic environment...
June 28, 2016: ACS Nano
Tomokazu Souma, Stuart W Tompson, Benjamin R Thomson, Owen M Siggs, Krishnakumar Kizhatil, Shinji Yamaguchi, Liang Feng, Vachiranee Limviphuvadh, Kristina N Whisenhunt, Sebastian Maurer-Stroh, Tammy L Yanovitch, Luba Kalaydjieva, Dimitar N Azmanov, Simone Finzi, Lucia Mauri, Shahrbanou Javadiyan, Emmanuelle Souzeau, Tiger Zhou, Alex W Hewitt, Bethany Kloss, Kathryn P Burdon, David A Mackey, Keri F Allen, Jonathan B Ruddle, Sing-Hui Lim, Steve Rozen, Khanh-Nhat Tran-Viet, Xiaorong Liu, Simon John, Janey L Wiggs, Francesca Pasutto, Jamie E Craig, Jing Jin, Susan E Quaggin, Terri L Young
Primary congenital glaucoma (PCG) is a devastating eye disease and an important cause of childhood blindness worldwide. In PCG, defects in the anterior chamber aqueous humor outflow structures of the eye result in elevated intraocular pressure (IOP); however, the genes and molecular mechanisms involved in the etiology of these defects have not been fully characterized. Previously, we observed PCG-like phenotypes in transgenic mice that lack functional angiopoietin-TEK signaling. Herein, we identified rare TEK variants in 10 of 189 unrelated PCG families and demonstrated that each mutation results in haploinsufficiency due to protein loss of function...
July 1, 2016: Journal of Clinical Investigation
Zhongkai Zhou, Yuyang Wang, Yumei Jiang, Yongjia Diao, Padraig Strappe, Paul Prenzler, Jamie Ayton, Chris Blanchard
BACKGROUND: Deep frying in oil is a popular cooking method around the world. However, the safety of deep-fried edible oil, which is ingested with fried food, is a concern, because the oil is exposed continuously to be re-used at a high temperature, leading to a number of well-known chemical reactions. Thus, this study investigates the changes in energy metabolism, colon histology and gut microbiota in rats following deep-fried oil consumption and explores the mechanisms involved in above alterations...
2016: Lipids in Health and Disease
Sandeep Rana, Elizabeth C Blowers, Calvin Tebbe, Jacob I Contreras, Prakash Radhakrishnan, Smitha Kizhake, Tian Zhou, Rajkumar N Rajule, Jamie L Arnst, Adnan R Munkarah, Ramandeep Rattan, Amarnath Natarajan
Design, synthesis, and evaluation of α-methylene-γ-butyrolactone analogues and their evaluation as anticancer agents is described. SAR identified a spirocyclic analogue 19 that inhibited TNFα-induced NF-κB activity, cancer cell growth and tumor growth in an ovarian cancer model. A second iteration of synthesis and screening identified 29 which inhibited cancer cell growth with low-μM potency. Our data suggest that an isatin-derived spirocyclic α-methylene-γ-butyrolactone is a suitable core for optimization to identify novel anticancer agents...
May 26, 2016: Journal of Medicinal Chemistry
Qiao Fan, Virginie J M Verhoeven, Robert Wojciechowski, Veluchamy A Barathi, Pirro G Hysi, Jeremy A Guggenheim, René Höhn, Veronique Vitart, Anthony P Khawaja, Kenji Yamashiro, S Mohsen Hosseini, Terho Lehtimäki, Yi Lu, Toomas Haller, Jing Xie, Cécile Delcourt, Mario Pirastu, Juho Wedenoja, Puya Gharahkhani, Cristina Venturini, Masahiro Miyake, Alex W Hewitt, Xiaobo Guo, Johanna Mazur, Jenifer E Huffman, Katie M Williams, Ozren Polasek, Harry Campbell, Igor Rudan, Zoran Vatavuk, James F Wilson, Peter K Joshi, George McMahon, Beate St Pourcain, David M Evans, Claire L Simpson, Tae-Hwi Schwantes-An, Robert P Igo, Alireza Mirshahi, Audrey Cougnard-Gregoire, Céline Bellenguez, Maria Blettner, Olli Raitakari, Mika Kähönen, Ilkka Seppala, Tanja Zeller, Thomas Meitinger, Janina S Ried, Christian Gieger, Laura Portas, Elisabeth M van Leeuwen, Najaf Amin, André G Uitterlinden, Fernando Rivadeneira, Albert Hofman, Johannes R Vingerling, Ya Xing Wang, Xu Wang, Eileen Tai-Hui Boh, M Kamran Ikram, Charumathi Sabanayagam, Preeti Gupta, Vincent Tan, Lei Zhou, Candice E H Ho, Wan'e Lim, Roger W Beuerman, Rosalynn Siantar, E-Shyong Tai, Eranga Vithana, Evelin Mihailov, Chiea-Chuen Khor, Caroline Hayward, Robert N Luben, Paul J Foster, Barbara E K Klein, Ronald Klein, Hoi-Suen Wong, Paul Mitchell, Andres Metspalu, Tin Aung, Terri L Young, Mingguang He, Olavi Pärssinen, Cornelia M van Duijn, Jie Jin Wang, Cathy Williams, Jost B Jonas, Yik-Ying Teo, David A Mackey, Konrad Oexle, Nagahisa Yoshimura, Andrew D Paterson, Norbert Pfeiffer, Tien-Yin Wong, Paul N Baird, Dwight Stambolian, Joan E Bailey Wilson, Ching-Yu Cheng, Christopher J Hammond, Caroline C W Klaver, Seang-Mei Saw, Jugnoo S Rahi, Jean-François Korobelnik, John P Kemp, Nicholas J Timpson, George Davey Smith, Jamie E Craig, Kathryn P Burdon, Rhys D Fogarty, Sudha K Iyengar, Emily Chew, Sarayut Janmahasatian, Nicholas G Martin, Stuart MacGregor, Liang Xu, Maria Schache, Vinay Nangia, Songhomitra Panda-Jonas, Alan F Wright, Jeremy R Fondran, Jonathan H Lass, Sheng Feng, Jing Hua Zhao, Kay-Tee Khaw, Nick J Wareham, Taina Rantanen, Jaakko Kaprio, Chi Pui Pang, Li Jia Chen, Pancy O Tam, Vishal Jhanji, Alvin L Young, Angela Döring, Leslie J Raffel, Mary-Frances Cotch, Xiaohui Li, Shea Ping Yip, Maurice K H Yap, Ginevra Biino, Simona Vaccargiu, Maurizio Fossarello, Brian Fleck, Seyhan Yazar, Jan Willem L Tideman, Milly Tedja, Margaret M Deangelis, Margaux Morrison, Lindsay Farrer, Xiangtian Zhou, Wei Chen, Nobuhisa Mizuki, Akira Meguro, Kari Matti Mäkelä
Myopia is the most common human eye disorder and it results from complex genetic and environmental causes. The rapidly increasing prevalence of myopia poses a major public health challenge. Here, the CREAM consortium performs a joint meta-analysis to test single-nucleotide polymorphism (SNP) main effects and SNP × education interaction effects on refractive error in 40,036 adults from 25 studies of European ancestry and 10,315 adults from 9 studies of Asian ancestry. In European ancestry individuals, we identify six novel loci (FAM150B-ACP1, LINC00340, FBN1, DIS3L-MAP2K1, ARID2-SNAT1 and SLC14A2) associated with refractive error...
March 29, 2016: Nature Communications
Sascha C T Nicklisch, Jamie E Spahn, Hongjun Zhou, Cristina M Gruian, J Herbert Waite
Adhesive mussel foot proteins (Mfps) rely in part on DOPA (3,4-dihydroxyphenyl-l-alanine) side chains to mediate attachment to mineral surfaces underwater. Oxidation of DOPA to Dopaquinone (Q) effectively abolishes the adsorption of Mfps to these surfaces. The thiol-rich mussel foot protein-6 (Mfp-6) rescues adhesion compromised by adventitious DOPA oxidation by reducing Q back to DOPA. The redox chemistry and kinetics of foot-extracted Mfp-6 were investigated by using a nonspecific chromogenic probe to equilibrate with the redox pool...
April 5, 2016: Biochemistry
Caixia Yan, Minghua Nie, Jamie R Lead, Yi Yang, Junliang Zhou, Ruth Merrifield, Mohammed Baalousha
Natural colloid properties and the impact of human activities on these properties are important considerations for studies seeking to understand the fate and transport of pollutants. In this study, the relationship between size and fluorescence properties of natural colloids from 4 different sources were quantified using a multi-method analytical approach including UV-visible and fluorescence spectroscopy, flow field flow fractionation (FlFFF) coupled online to fluorescence spectrometer, and atomic force microscopy (AFM)...
June 1, 2016: Science of the Total Environment
Christopher J Portier, Bruce K Armstrong, Bruce C Baguley, Xaver Baur, Igor Belyaev, Robert Bellé, Fiorella Belpoggi, Annibale Biggeri, Maarten C Bosland, Paolo Bruzzi, Lygia Therese Budnik, Merete D Bugge, Kathleen Burns, Gloria M Calaf, David O Carpenter, Hillary M Carpenter, Lizbeth López-Carrillo, Richard Clapp, Pierluigi Cocco, Dario Consonni, Pietro Comba, Elena Craft, Mohamed Aqiel Dalvie, Devra Davis, Paul A Demers, Anneclaire J De Roos, Jamie DeWitt, Francesco Forastiere, Jonathan H Freedman, Lin Fritschi, Caroline Gaus, Julia M Gohlke, Marcel Goldberg, Eberhard Greiser, Johnni Hansen, Lennart Hardell, Michael Hauptmann, Wei Huang, James Huff, Margaret O James, C W Jameson, Andreas Kortenkamp, Annette Kopp-Schneider, Hans Kromhout, Marcelo L Larramendy, Philip J Landrigan, Lawrence H Lash, Dariusz Leszczynski, Charles F Lynch, Corrado Magnani, Daniele Mandrioli, Francis L Martin, Enzo Merler, Paola Michelozzi, Lucia Miligi, Anthony B Miller, Dario Mirabelli, Franklin E Mirer, Saloshni Naidoo, Melissa J Perry, Maria Grazia Petronio, Roberta Pirastu, Ralph J Portier, Kenneth S Ramos, Larry W Robertson, Theresa Rodriguez, Martin Röösli, Matt K Ross, Deodutta Roy, Ivan Rusyn, Paulo Saldiva, Jennifer Sass, Kai Savolainen, Paul T J Scheepers, Consolato Sergi, Ellen K Silbergeld, Martyn T Smith, Bernard W Stewart, Patrice Sutton, Fabio Tateo, Benedetto Terracini, Heinz W Thielmann, David B Thomas, Harri Vainio, John E Vena, Paolo Vineis, Elisabete Weiderpass, Dennis D Weisenburger, Tracey J Woodruff, Takashi Yorifuji, Il Je Yu, Paola Zambon, Hajo Zeeb, Shu-Feng Zhou
No abstract text is available yet for this article.
August 2016: Journal of Epidemiology and Community Health
Zhengyu He, Wenshuo Xu, Yingqiu Zhou, Xiaochen Wang, Yuewen Sheng, Youmin Rong, Shaoqiang Guo, Junying Zhang, Jason M Smith, Jamie H Warner
Monolayer transition metal dichalcogenides (TMDs) are direct band gap semiconductors, and their 2D structure results in large binding energies for excitons, trions, and biexcitons. The ability to explore many-body effects in these monolayered structures has made them appealing for future optoelectronic and photonic applications. The band structure changes for bilayer TMDs with increased contributions from indirect transitions, and this has limited similar in-depth studies of biexcitons. Here, we study biexciton emission in bilayer WS2 grown by chemical vapor deposition as a function of temperature...
February 23, 2016: ACS Nano
Jie Li, Yi Kuang, Junfeng Shi, Jie Zhou, Jamie E Medina, Rong Zhou, Dan Yuan, Cuihong Yang, Huaimin Wang, Zhimou Yang, Jianfeng Liu, Daniela M Dinulescu, Bing Xu
Anticancer drug resistance demands innovative approaches that boost the activity of drugs against drug-resistant cancers without increasing the systemic toxicity. Here we show the use of enzyme-instructed self-assembly (EISA) to generate intracellular supramolecular assemblies that drastically boost the activity of cisplatin against drug-resistant ovarian cancer cells. We design and synthesize small peptide precursors as the substrates of carboxylesterase (CES). CES cleaves the ester bond pre-installed on the precursors to form the peptides that self-assemble in water to form nanofibers...
November 2, 2015: Angewandte Chemie
Michael R Wasserman, Arto Pulk, Zhou Zhou, Roger B Altman, John C Zinder, Keith D Green, Sylvie Garneau-Tsodikova, Jamie H Doudna Cate, Scott C Blanchard
Dynamic remodelling of intersubunit bridge B2, a conserved RNA domain of the bacterial ribosome connecting helices 44 (h44) and 69 (H69) of the small and large subunit, respectively, impacts translation by controlling intersubunit rotation. Here we show that aminoglycosides chemically related to neomycin-paromomycin, ribostamycin and neamine-each bind to sites within h44 and H69 to perturb bridge B2 and affect subunit rotation. Neomycin and paromomycin, which only differ by their ring-I 6'-polar group, drive subunit rotation in opposite directions...
2015: Nature Communications
Chenkun Zhou, Yu Tian, Zhao Yuan, Mingu Han, Jamie Wang, Lei Zhu, Maliheh Shaban Tameh, Chen Huang, Biwu Ma
Photoinduced structural change (PSC) is a fundamental excited-state dynamic process in chemical and biological systems. However, precise control of PSC processes is very challenging, owing to the lack of guidelines for designing excited-state potential energy surfaces (PESs). A series of rationally designed butterfly-like phosphorescent binuclear platinum complexes that undergo controlled PSC by Pt-Pt distance shortening and exhibit tunable dual (greenish-blue and red) emission are herein reported. Based on the Bell-Evans-Polanyi principle, it is demonstrated how the energy barrier of the PSC, which can be described as a chemical-reaction-like process between the two energy minima on the first triplet excited-state PES, can be controlled by synthetic means...
August 10, 2015: Angewandte Chemie
Yu Ji Lai, Er Yong Liu, Li Ming Wang, Jamie P Morano, Ning Wang, Kaveh Khoshnood, Lin Zhou, Shi Ming Cheng
OBJECTIVE: To investigate the risk factors attributable to tuberculosis-related deaths in areas with human immunodeficiency virus (HIV) infection epidemics. METHODS: A prospective cohort study of newly registered patients in tuberculosis (TB) dispensaries in six representative Chinese provinces was conducted from September 1, 2009 to August 31, 2011. Risk factors for TB-associated death were identified through logistic regression analysis. RESULTS: Of 19,103 newly registered pulmonary TB patients, 925 (4...
June 2015: Biomedical and Environmental Sciences: BES
Caixia Yan, Minghua Nie, Yi Yang, Junliang Zhou, Min Liu, Mohammed Baalousha, Jamie R Lead
The effect of colloids on the occurrence, phase distribution and photolysis of twenty-seven emerging organic contaminants (EOCs) was studied in domestic and livestock wastewaters (DW and LW), respectively. Filtered water (<1 μm) was separated into permeate (<1 kDa) and retentate (1 kDa-1 μm) by cross flow ultrafiltration. Results indicated that total concentration of EOCs ranged from 1220 ng L(-1) in permeate of DW to 5065 ng L(-1) in retentate of LW. The average EOC fraction associated with colloids was 13...
December 15, 2015: Journal of Hazardous Materials
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