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https://www.readbyqxmd.com/read/28541592/cath-lab-costs-in-patients-undergoing-percutaneous-coronary-angioplasty-detailed-analysis-of-consecutive-procedures
#1
Beata Dziki, Izabela Miechowicz, Piotr Iwachów, Michał Kuzemczak, Piotr Kałmucki, Andrzej Szyszka, Artur Baszko, Tomasz Siminiak
BACKGROUND: Costs of percutaneous coronary interventions (PCI) have important impact on health care expenditures. Despite the present stress upon the cost-effectiveness issues in medicine, few comprehensive data exist on costs and resource use in different clinical settings. AIM: To assess catheterization laboratory costs related to use of drugs and single-use devices in patients undergoing PCI due to coronary artery disease. METHODS: Retrospective analysis of 1500 consecutive PCIs (radial approach, n=1103; femoral approach, n=397) performed due to myocardial infarction type STEMI (n=345) and NSTEMI (n=426) as well as unstable (UA; n=489) and (SA; n=241) angina was undertaken...
May 25, 2017: Kardiologia Polska
https://www.readbyqxmd.com/read/28415138/the-roles-of-valuation-and-reward-processing-in-cognitive-function-and-psychiatric-disorders
#2
REVIEW
Sébastien Hélie, Farzin Shamloo, Keisha Novak, Dan Foti
In neuroeconomics, valuation refers to the process of assigning values to states and actions on the basis of the animal's current representation of the environment, while reward processing corresponds to processing the feedback received from the environment to update the values of states and actions. In this article, we review the brain circuits associated with valuation and reward processing and argue that these are fundamental processes critical to many cognitive functions. Specifically, we focus on the role of valuation and reward processing in attention, memory, decision making, and learning...
May 2017: Annals of the New York Academy of Sciences
https://www.readbyqxmd.com/read/28357171/value-based-care-in-the-worldwide-battle-against-cancer
#3
REVIEW
Niloufer J Johansen, Christobel M Saunders
Globally, an increasing and aging population is contributing to the prevalence of cancer. To be effective, cancer care needs to involve the coordination of multidisciplinary specialties, and also needs to be affordable, accessible, and capable of producing optimal patient outcomes. Porter and Teisberg (2006) have postulated that shifting current healthcare strategies from volume-based to patient-centric care redirects economic competition to providing treatments which promote the best patient outcomes while driving down costs...
February 17, 2017: Curēus
https://www.readbyqxmd.com/read/28344971/how-to-train-a-cell-cutting-edge-molecular-tools
#4
REVIEW
Jakub Czapiński, Michał Kiełbus, Joanna Kałafut, Michał Kos, Andrzej Stepulak, Adolfo Rivero-Müller
In biological systems, the formation of molecular complexes is the currency for all cellular processes. Traditionally, functional experimentation was targeted to single molecular players in order to understand its effects in a cell or animal phenotype. In the last few years, we have been experiencing rapid progress in the development of ground-breaking molecular biology tools that affect the metabolic, structural, morphological, and (epi)genetic instructions of cells by chemical, optical (optogenetic) and mechanical inputs...
2017: Frontiers in Chemistry
https://www.readbyqxmd.com/read/28283488/quality-of-clinical-practice-guidelines-in-delirium-a-systematic-appraisal
#5
Shirley H Bush, Katie L Marchington, Meera Agar, Daniel H J Davis, Lindsey Sikora, Tammy W Y Tsang
OBJECTIVE: To determine the accessibility and currency of delirium guidelines, guideline summary papers and evaluation studies, and critically appraise guideline quality. DESIGN: Systematic literature search for formal guidelines (in English or French) with focus on delirium assessment and/or management in adults (≥18 years), guideline summary papers and evaluation studies.Full appraisal of delirium guidelines published between 2008 and 2013 and obtaining a 'Rigour of Development' domain screening score cut-off of >40% using the Appraisal of Guidelines for Research and Evaluation (AGREE II) instrument...
March 10, 2017: BMJ Open
https://www.readbyqxmd.com/read/28076853/pyruvate-dehydrogenase-expression-is-negatively-associated-with-cell-stemness-and-worse-clinical-outcome-in-prostate-cancers
#6
Yali Zhong, Xiaoli Li, Yasai Ji, Xiaoran Li, Yaqing Li, Dandan Yu, Yuan Yuan, Jian Liu, Huixiang Li, Mingzhi Zhang, Zhenyu Ji, Dandan Fan, Jianguo Wen, Mariusz Adam Goscinski, Long Yuan, Bin Hao, Jahn M Nesland, Zhenhe Suo
Cells generate adenosine-5'-triphosphate (ATP), the major currency for energy-consuming reactions, through mitochondrial oxidative phosphorylation (OXPHOS) and glycolysis. One of the remarkable features of cancer cells is aerobic glycolysis, also known as the "Warburg Effect", in which cancer cells rely preferentially on glycolysis instead of mitochondrial OXPHOS as the main energy source even in the presence of high oxygen tension. One of the main players in controlling OXPHOS is the mitochondrial gatekeeperpyruvate dehydrogenase complex (PDHc) and its major subunit is E1α (PDHA1)...
February 21, 2017: Oncotarget
https://www.readbyqxmd.com/read/27938631/an-evaluation-of-the-competencies-of-primary-health-care-clinic-nursing-managers-in-two-south-african-provinces
#7
Pascalia O Munyewende, Jonathan Levin, Laetitia C Rispel
BACKGROUND: Managerial competencies to enhance individual and organisational performance have gained currency in global efforts to strengthen health systems. Competent managers are essential in the implementation of primary health care (PHC) reforms that aim to achieve universal health coverage. OBJECTIVE: To evaluate the competencies of PHC clinic nursing managers in two South African provinces. DESIGN: A cross-sectional study was conducted in two South African provinces...
2016: Global Health Action
https://www.readbyqxmd.com/read/27933152/ensuring-availability-of-in-date-and-fit-for-purpose-emergency-guidelines-in-all-anaesthetic-areas-throughout-the-south-east-scotland-deanery
#8
Elise Hindle
Our aim was to institute a system whereby emergency anaesthetic guidelines are available in >90% of appropriate clinical areas throughout each of the acute hospital sites in three health board administrative regions, and whereby >90% of available guidelines are deemed to be in date and fit for purpose. Our objective was to achieve these targets within 6 months. Using quality improvement methodology, we inventoried available emergency anaesthetic guidelines in 132 locations throughout seven acute care hospitals...
2016: BMJ Quality Improvement Reports
https://www.readbyqxmd.com/read/27819748/topical-antibiotics-for-preventing-surgical-site-infection-in-wounds-healing-by-primary-intention
#9
REVIEW
Clare F Heal, Jennifer L Banks, Phoebe D Lepper, Evangelos Kontopantelis, Mieke L van Driel
BACKGROUND: Surgical site infections (SSI) can delay wound healing, impair cosmetic outcome and increase healthcare costs. Topical antibiotics are sometimes used to reduce microbial contaminant exposure following surgical procedures, with the aim of reducing SSIs. OBJECTIVES: The primary objective of this review was to determine whether the application of topical antibiotics to surgical wounds that are healing by primary intention reduces the incidence of SSI and whether it increases the incidence of adverse outcomes (allergic contact dermatitis, infections with patterns of antibiotic resistance and anaphylaxis)...
November 7, 2016: Cochrane Database of Systematic Reviews
https://www.readbyqxmd.com/read/27766615/continuous-improvement-in-national-art-standards-by-the-rtac-accreditation-system-in-australia-and-new-zealand
#10
Keith Harrison, John Peek, Michael Chapman, Mark Bowman
BACKGROUND: Assisted reproductive technology (ART) clinics in Australia and New Zealand are accredited and licensed against a Code of Practice audited by certifying bodies accredited by the Joint Accreditation System for Australia and New Zealand (JAS-ANZ). The system is administered by the Reproductive Technology Accreditation Committee (RTAC) of the Fertility Society of Australia. AIMS: To review the incidence of variances and findings identified by certifying bodies in Australian and New Zealand ART clinics within the currency of a single version of the Code of Practice...
February 2017: Australian & New Zealand Journal of Obstetrics & Gynaecology
https://www.readbyqxmd.com/read/27706840/models-of-partnership-within-family-centred-care-in-the-acute-paediatric-setting-a-discussion-paper
#11
Christine Dennis, Pamela Baxter, Jenny Ploeg, Susan Blatz
AIMS: A discussion of partnership in the context of family-centred care in the acute paediatric setting, through a critical analysis of partnership models. BACKGROUND: Paediatric healthcare practitioners understand the importance of family-centred care, but struggle with how to translate the core tenets into action and are confused by several rival terms. Partnering relationships are included in definitions of family-centred care, yet less is known about strategies to fully engage or support parents in these partnerships...
October 5, 2016: Journal of Advanced Nursing
https://www.readbyqxmd.com/read/27697235/information-needs-of-botswana-health-care-workers-and-perceptions-of-wikipedia
#12
Elizabeth Park, Tiny Masupe, Joseph Joseph, Ari Ho-Foster, Afton Chavez, Swetha Jammalamadugu, Andrew Marek, Ruth Arumala, Dineo Ketshogileng, Ryan Littman-Quinn, Carrie Kovarik
BACKGROUND: Since the UN Human Rights Council's recognition on the subject in 2011, the right to access the Internet and information is now considered one of the most basic human rights of global citizens [1,2]. Despite this, an information gap between developed and resource-limited countries remains, and there is scant research on actual information needs of workers themselves. The Republic of Botswana represents a fertile ground to address existing gaps in research, policy, and practice, due to its demonstrated gap in access to information and specialists among rural health care workers (HCWs), burgeoning mHealth capacity, and a timely offer from Orange Telecommunications to access Wikipedia for free on mobile platforms for Botswana subscribers...
November 2016: International Journal of Medical Informatics
https://www.readbyqxmd.com/read/27563437/initiating-therapeutic-relaxation-in-britain-a-twentieth-century-strategy-for-health-and-wellbeing
#13
Ayesha Nathoo
In 1972, a British charity, Relaxation for Living, was established "to promote the teaching of physical relaxation, to combat stress, strain, anxiety and the tension of modern life, and to reduce fatigue". This article explores the origins and development of "physical relaxation" techniques and ideologies, starting in the interwar period, and the development of practical, therapeutic, social and cultural frameworks necessary for such an organization to come into being in 1970s Britain. It traces how relaxation was reconstituted as a scientifically-based skill that could be learnt and taught, imbued with therapeutic value for combating and preventing specific physical ailments and enhancing individual health and wellbeing...
July 19, 2016: Palgrave Communications
https://www.readbyqxmd.com/read/27561277/the-global-anticoagulant-registry-in-the-field-atrial-fibrillation%C3%A2-garfield-af-exploring-the-changes-in-anticoagulant-practice-in-patients-with-non-valvular-atrial-fibrillation-in-the-netherlands
#14
V Ten Cate, H Ten Cate, F W A Verheugt
There are over 385,000 cases of atrial fibrillation (AF) in the Netherlands, with over 45,000 new cases each year. Among other things, AF patients are at high risk of stroke. Patients are often prescribed oral anticoagulation, such as vitamin K antagonists (VKA), to mitigate these risks. A recently introduced class of oral anticoagulants, non-vitamin K antagonists (NOAC), is quickly gaining currency in global clinical practice. This study provides insight into the changes these new drugs will bring about in Dutch clinical practice...
October 2016: Netherlands Heart Journal
https://www.readbyqxmd.com/read/27355575/neuropsychiatry-of-fragile-x-premutation-carriers-with-and-without-fragile-x-associated-tremor-ataxia-syndrome-implications-for-neuropsychology
#15
REVIEW
James A Bourgeois
OBJECTIVES: Clinical neuropsychologists benefit from clinical currency in recently ascertained neuropsychiatric illness, such as fragile X premutation (FXPM) disorders. The author reviewed the clinical literature through 2016 for neuropsychiatric phenotypes in FXPM disorders, including patients with fragile X-associated tremor/ataxia syndrome (FXTAS). METHODS: A PubMed search using the search terms 'Fragile X,' 'Premutation,' 'Carriers,' 'Psychiatric,' 'Dementia,' 'Mood,' and 'Anxiety' for citations in the clinical literature through 2016 was reviewed for studies specifically examining the neuropsychiatric phenotype in FXPM patients...
August 2016: Clinical Neuropsychologist
https://www.readbyqxmd.com/read/27354069/what-evidence-is-there-for-a-delay-in-diagnostic-coding-of-ra-in-uk-general-practice-records-an-observational-study-of-free-text
#16
Elizabeth Ford, John Carroll, Helen Smith, Kevin Davies, Rob Koeling, Irene Petersen, Greta Rait, Jackie Cassell
OBJECTIVES: Much research with electronic health records (EHRs) uses coded or structured data only; important information captured in the free text remains unused. One dimension of EHR data quality assessment is 'currency' or timeliness, that is, data are representative of the patient state at the time of measurement. We explored the use of free text in UK general practice patient records to evaluate delays in recording of rheumatoid arthritis (RA) diagnosis. We also aimed to locate and quantify disease and diagnostic information recorded only in text...
2016: BMJ Open
https://www.readbyqxmd.com/read/27262153/dissemination-of-evidence-from-systematic-reviews-through-academic-cme-providers-a-feasibility-study
#17
Michael Fordis, Jason E King, Francesca Bonaduce de Nigris, Robert Morrow, Robert B Baron, John R Kues, James C Norton, Harold Kessler, Paul E Mazmanian, Lois Colburn
INTRODUCTION: Although systematic reviews represent a source of best evidence to support clinical decision-making, reviews are underutilized by clinicians. Barriers include lack of awareness, familiarity, and access. Efforts to promote utilization have focused on reaching practicing clinicians, leaving unexplored the roles of continuing medical education (CME) directors and faculty in promoting systematic review use. This study explored the feasibility of working with CME directors and faculty for that purpose...
2016: Journal of Continuing Education in the Health Professions
https://www.readbyqxmd.com/read/27260476/how-to-improve-vital-sign-data-quality-for-use-in-clinical-decision-support-systems-a-qualitative-study-in-nine-swedish-emergency-departments
#18
Niclas Skyttberg, Joana Vicente, Rong Chen, Hans Blomqvist, Sabine Koch
BACKGROUND: Vital sign data are important for clinical decision making in emergency care. Clinical Decision Support Systems (CDSS) have been advocated to increase patient safety and quality of care. However, the efficiency of CDSS depends on the quality of the underlying vital sign data. Therefore, possible factors affecting vital sign data quality need to be understood. This study aims to explore the factors affecting vital sign data quality in Swedish emergency departments and to determine in how far clinicians perceive vital sign data to be fit for use in clinical decision support systems...
June 4, 2016: BMC Medical Informatics and Decision Making
https://www.readbyqxmd.com/read/27246433/performing-dual-roles-in-education-and-practice
#19
Natasha Hackett, Jane Harvey-Lloyd, Nickey Rooke
AIM: To examine the benefits and challenges of dual posts, defined here as lecturers who work in clinical practice and have separate contracts with different organisations. METHODS: A case study approach was used to collate different perspectives. Equal numbers of participants were selected from lecturers (n=3) and dual post holders (n= 3), and one manager was included (n=1). Semi-structured interviews were recorded and transcribed verbatim to collect data. Key words were identified then highlighted throughout the transcripts and text retrievers searched the large amounts of data gathered...
June 2016: Nursing Management (Harrow)
https://www.readbyqxmd.com/read/27241319/clinical-trial-data-as-public-goods-fair-trade-and-the-virtual-knowledge-bank-as-a-solution-to-the-free-rider-problem-a-framework-for-the-promotion-of-innovation-by-facilitation-of-clinical-trial-data-sharing-among-biopharmaceutical-companies-in-the-era-of
#20
Nikolaos Evangelatos, Matthias Reumann, Hans Lehrach, Angela Brand
BACKGROUND: Knowledge in the era of Omics and Big Data has been increasingly conceptualized as a public good. Sharing of de-identified patient data has been advocated as a means to increase confidence and public trust in the results of clinical trials. On the other hand, research has shown that the current research and development model of the biopharmaceutical industry has reached its innovation capacity. In response to that, the biopharmaceutical industry has adopted open innovation practices, with sharing of clinical trial data being among the most interesting ones...
2016: Public Health Genomics
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