Amelia Palermo, Shen Li, Johanna Ten Hoeve, Akshay Chellappa, Alexandra Morris, Barbara Dillon, Feiyang Ma, Yijie Wang, Edward Cao, Byourak Shabane, Rebeca Acín-Perez, Anton Petcherski, A Jake Lusis, Stanley Hazen, Orian S Shirihai, Matteo Pellegrini, Vaithilingaraja Arumugaswami, Thomas G Graeber, Arjun Deb
The ketogenic diet (KD) has demonstrated benefits in numerous clinical studies and animal models of disease in modulating the immune response and promoting a systemic anti-inflammatory state. Here we investigate the effects of a KD on systemic toxicity in mice following SARS-CoV-2 infection. Our data indicate that under KD, SARS-CoV-2 reduces weight loss with overall improved animal survival. Muted multi-organ transcriptional reprogramming and metabolism rewiring suggest that a KD initiates and mitigates systemic changes induced by the virus...
November 3, 2023: Communications Biology