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https://www.readbyqxmd.com/read/27887877/a-discrete-stage-structured-model-of-california-newt-population-dynamics-during-a-period-of-drought
#1
Marjorie T Jones, William R Milligan, Lee B Kats, Thomas L Vandergon, Rodney L Honeycutt, Robert N Fisher, Courtney L Davis, Timothy A Lucas
We introduce a mathematical model for studying the population dynamics under drought of the California newt (Taricha torosa), a species of special concern in the state of California. Since 2012, California has experienced a record-setting drought, and multiple studies predict drought conditions currently underway will persist and even increase in severity. Recent declines and local extinctions of California newt populations in Santa Monica Mountain streams motivate our study of the impact of drought on newt population sizes...
November 22, 2016: Journal of Theoretical Biology
https://www.readbyqxmd.com/read/27884961/therapeutic-silencing-of-fat-specific-protein-27-improves-glycemic-control-in-mouse-models-of-obesity-and-insulin-resistance
#2
Cédric Langhi, Noemí Arias, Ananthi Rajamoorthi, Jeannine Basta, Richard G Lee, Ángel Baldán
Obesity is a component of the metabolic syndrome, mechanistically linked to diabetes, fatty liver disease, and cardiovascular disease. Proteins that regulate the metabolic fate of intracellular lipid droplets are potential therapeutic candidates to treat obesity and its related consequences. CIDEC (cell death-inducing DFFA-like effector C), also known in mice as Fsp27 (fat-specific protein 27), is a lipid droplet-associated protein that prevents lipid mobilization and promotes intracellular lipid storage. The consequences of complete loss of FSP27 on hepatic metabolism and on insulin resistance are controversial, as both healthy and deleterious lipodystrophic phenotypes have been reported in Fsp27-/- mice...
November 24, 2016: Journal of Lipid Research
https://www.readbyqxmd.com/read/27882458/personal-identity-development-in-hispanic-immigrant-adolescents-links-with-positive-psychosocial-functioning-depressive-symptoms-and-externalizing-problems
#3
Seth J Schwartz, Jennifer B Unger, Alan Meca, Elma I Lorenzo-Blanco, Lourdes Baezconde-Garbanati, Miguel Ángel Cano, Brandy Piña-Watson, José Szapocznik, Byron L Zamboanga, David Córdova, Andrea J Romero, Tae Kyoung Lee, Daniel W Soto, Juan A Villamar, Karina M Lizzi, Sabrina E Des Rosiers, Monica Pattarroyo
The present study was designed to examine trajectories of personal identity coherence and confusion among Hispanic recent-immigrant adolescents, as well as the effects of these trajectories on psychosocial and risk-taking outcomes. Personal identity is extremely important in anchoring young immigrants during a time of acute cultural change. A sample of 302 recently immigrated (5 years or less in the United States at baseline) Hispanic adolescents (Mage = 14.51 years at baseline; SD = 0.88 years, range 14-17) from Miami and Los Angeles (47 % girls) completed measures of personal identity coherence and confusion at the first five waves of a six-wave longitudinal study; and reported on positive psychosocial functioning, depressive symptoms, and externalizing problems at baseline and at Time 6...
November 23, 2016: Journal of Youth and Adolescence
https://www.readbyqxmd.com/read/27864161/maintenance-versus-induction-therapy-choice-on-outcomes-after-autologous-transplantation-for-multiple-myeloma
#4
Robert F Cornell, Anita D'Souza, Adetola A Kassim, Luciano J Costa, Racquel D Innis-Shelton, Mei-Jie Zhang, Jiaxing Huang, Muneer Abidi, Jack Aiello, Gorgun Akpek, Asad Bashey, Qaiser Bashir, Jan Cerny, Raymond Comenzo, Miguel Angel Diaz, César Freytes, Robert Peter Gale, Siddhartha Ganguly, Mehdi Hamadani, Shahrukh Hashmi, Leona Holmberg, Nasheed Hossain, Rammurti T Kamble, Mohamed Kharfan-Dabaja, Tamila Kindwall-Keller, Robert Kyle, Shaji Kumar, Hillard Lazarus, Cindy Lee, Angelo Maiolino, David I Marks, Kenneth Meehan, Joe Mikhael, Rajneesh Nath, Taiga Nishihori, Richard F Olsson, Muthalagu Ramanathan, Ayman Saad, Sachiko Seo, Saad Usmani, David Vesole, Ravi Vij, Dan Vogl, Baldeep M Wirk, Jean Yared, Amrita Krishnan, Tomer Mark, Yago Nieto, Parameswaran Hari
Bortezomib (V), lenalidomide (R), cyclophosphamide (C) and dexamethasone (D) are components of the most commonly used modern doublet (RD, VD) or triplet (VRD, CVD) initial induction regimens prior to autologous hematopoietic cell transplantation (AHCT) for multiple myeloma (MM) in the US. In this study we evaluated 693 patients receiving "upfront" AHCT after initial induction therapy with modern doublet or triplet regimens using data reported to the Center for International Blood and Marrow Transplant Research from 2008-2013...
November 15, 2016: Biology of Blood and Marrow Transplantation
https://www.readbyqxmd.com/read/27851748/chromosomal-instability-estimation-based-on-next-generation-sequencing-and-single-cell-genome-wide-copy-number-variation-analysis
#5
Stephanie B Greene, Angel E Dago, Laura J Leitz, Yipeng Wang, Jerry Lee, Shannon L Werner, Steven Gendreau, Premal Patel, Shidong Jia, Liangxuan Zhang, Eric K Tucker, Michael Malchiodi, Ryon P Graf, Ryan Dittamore, Dena Marrinucci, Mark Landers
Genomic instability is a hallmark of cancer often associated with poor patient outcome and resistance to targeted therapy. Assessment of genomic instability in bulk tumor or biopsy can be complicated due to sample availability, surrounding tissue contamination, or tumor heterogeneity. The Epic Sciences circulating tumor cell (CTC) platform utilizes a non-enrichment based approach for the detection and characterization of rare tumor cells in clinical blood samples. Genomic profiling of individual CTCs could provide a portrait of cancer heterogeneity, identify clonal and sub-clonal drivers, and monitor disease progression...
2016: PloS One
https://www.readbyqxmd.com/read/27826293/assessing-marine-microbial-induced-corrosion-at-santa-catalina-island-california
#6
Gustavo A Ramírez, Colleen L Hoffman, Michael D Lee, Ryan A Lesniewski, Roman A Barco, Arkadiy Garber, Brandy M Toner, Charles G Wheat, Katrina J Edwards, Beth N Orcutt
High iron and eutrophic conditions are reported as environmental factors leading to accelerated low-water corrosion, an enhanced form of near-shore microbial induced corrosion. To explore this hypothesis, we deployed flow-through colonization systems in laboratory-based aquarium tanks under a continuous flow of surface seawater from Santa Catalina Island, CA, USA, for periods of 2 and 6 months. Substrates consisted of mild steel - a major constituent of maritime infrastructure - and the naturally occurring iron sulfide mineral pyrite...
2016: Frontiers in Microbiology
https://www.readbyqxmd.com/read/27816212/novel-presenilin-1-mutation-p-f386i-in-a-chinese-family-with-early-onset-alzheimer-s-disease
#7
Yat-Fung Shea, Angel On-Kei Chan, Leung-Wing Chu, Shui-Ching Lee, Chun-Yin Law, Chung-Him See, Kit-Ling Yiu, Patrick Ka-Chun Chiu
Autosomal dominant familial Alzheimer's disease accounts for 0.5% of all Alzheimer's disease. A familial Alzheimer's disease Chinese family, with 7 affected family members, underwent PSEN1 screening in 3 affected family members. A heterozygous novel missense mutation in the PSEN1 gene c.1156T>A, altering phenylalanine to isoleucine at codon 386, was identified. Because the change occurred in conserved domains of this gene and cosegregated with affected family members, this change may have a mutagenic and probably pathogenic effect...
October 15, 2016: Neurobiology of Aging
https://www.readbyqxmd.com/read/27796927/an-in-vitro-study-of-the-antifungal-activity-of-trichoderma-virens-7b-and-a-profile-of-its-non-polar-antifungal-components-released-against-ganoderma-boninense
#8
Lee Pei Lee Angel, Mohd Termizi Yusof, Intan Safinar Ismail, Bonnie Tay Yen Ping, Intan Nur Ainni Mohamed Azni, Norman Hj Kamarudin, Shamala Sundram
Ganoderma boninense is the causal agent of a devastating disease affecting oil palm in Southeast Asian countries. Basal stem rot (BSR) disease slowly rots the base of palms, which radically reduces productive lifespan of this lucrative crop. Previous reports have indicated the successful use of Trichoderma as biological control agent (BCA) against G. boninense and isolate T. virens 7b was selected based on its initial screening. This study attempts to decipher the mechanisms responsible for the inhibition of G...
November 2016: Journal of Microbiology / the Microbiological Society of Korea
https://www.readbyqxmd.com/read/27793324/central-venous-parathyroid-hormone-monitoring-using-a-novel-specific-anatomic-method-accurately-predicts-cure-during-minimally-invasive-parathyroidectomy
#9
Courtney M Edwards, Jessica Folek, Samantha Dayawansa, Cara M Govednik, Courtney E Quinn, Benjamin R Sigmond, Cortney Y Lee, Melissa S Angel, John C Hendricks, Terry C Lairmore
BACKGROUND: Measurement of intraoperative parathyroid hormone (PTH) levels is an important adjunct to confirm biochemical cure during parathyroidectomy. The purpose of this study was to evaluate a simplified anatomic technique for PTH sampling from the central veins through the minimally invasive neck incision, and to compare the predictive accuracy of central and peripheral PTH values. METHODS: A specific anatomic method for central PTH sampling was employed in 48 patients...
September 30, 2016: American Journal of Surgery
https://www.readbyqxmd.com/read/27785671/a-crosswalk-between-ucla-and-lower-extremity-activity-scales
#10
Hassan M K Ghomrawi, Yuo-Yu Lee, Christina Herrero, Amethia Joseph, Douglas Padgett, Geoffrey Westrich, Michael Parks, Stephen Lyman
BACKGROUND: The University of California, Los Angeles (UCLA) activity scale and the Lower Extremity Activity Scale (LEAS) are the two most-widely used and rigorously developed scales for assessing activity level in patients having joint replacement. However, the two scales are not convertible, and the level of correlation between the two is not clear. Creating a crosswalk between these scales; that is, a concordance table to convert scores from one scale to the other and vice versa, will help compare results from existing studies using either scale, and pool those results for meta-analyses...
October 26, 2016: Clinical Orthopaedics and related Research
https://www.readbyqxmd.com/read/27765500/loss-of-reduction-and-complications-of-coracoclavicular-ligament-reconstruction-with-autogenous-tendon-graft-in-acute-acromioclavicular-dislocations
#11
Nam Hong Choi, Seok Min Lim, Sang Young Lee, Tae Kang Lim
BACKGROUND: This study was conducted to report loss of reduction and complications after single-tunnel coracoclavicular (CC) ligament reconstruction with autogenous semitendinosus tendon graft for acute acromioclavicular (AC) joint dislocations. METHODS: This retrospective study included patients with acute, unstable AC dislocations (surgery within 6 weeks after trauma). We excluded patients with chronic injury and distal clavicle fractures with CC ligaments disruption...
October 17, 2016: Journal of Shoulder and Elbow Surgery
https://www.readbyqxmd.com/read/27762653/resting-state-magnetoencephalography-reveals-different-patterns-of-aberrant-functional-connectivity-in-combat-related-mild-traumatic-brain-injury
#12
Ming-Xiong Huang, Deborah L Harrington, Ashley Robb Swan, Annemarie Angeles Quinto, Sharon Nichols, Angela Drake, Tao Song, Mithun Diwakar, Charles W Huang, Victoria B Risbrough, Anders Dale, Hauke Bartsch, Scott Matthews, Jeffrey W Huang, Roland R Lee, Dewleen G Baker
Blast mild traumatic brain injury (mTBI) is a leading cause of sustained impairment in military service members and veterans. However, the mechanism of persistent disability is not fully understood. The present study investigated disturbances in brain functioning in mTBI participants using a source-imaging-based approach to analyze functional connectivity (FC) from resting-state magnetoencephalography (rs-MEG). Study participants included 26 active-duty service members or veterans who had blast mTBI with persistent post-concussive symptoms, and 22 healthy control active-duty service members or veterans...
December 2, 2016: Journal of Neurotrauma
https://www.readbyqxmd.com/read/27761266/ambulatory-heart-rate-of-professional-taxi-drivers-while-driving-without-their-typical-psychosocial-work-stressors-a-pilot-study
#13
BongKyoo Choi, SangJun Choi, JeeYeon Jeong, JiWon Lee, Shi Shu, Nu Yu, SangBaek Ko, Yifang Zhu
BACKGROUND: Few studies have examined ambulatory cardiovascular physiological parameters of taxi drivers while driving in relation to their occupational hazards. This study aims to investigate and quantify the impact of worksite physical hazards as a whole on ambulatory heart rate of professional taxi drivers while driving without their typical worksite psychosocial stressors. METHODS: Ambulatory heart rate (HRdriving) of 13 non-smoking male taxi drivers (24 to 67 years old) while driving was continuously assessed on their 6-hour experimental on-road driving in Los Angeles...
2016: Annals of Occupational and Environmental Medicine
https://www.readbyqxmd.com/read/27731373/toxicity-of-zno-and-tio2-to-escherichia-coli-cells
#14
Yu Hang Leung, Xiaoying Xu, Angel P Y Ma, Fangzhou Liu, Alan M C Ng, Zhiyong Shen, Lee A Gethings, Mu Yao Guo, Aleksandra B Djurišić, Patrick K H Lee, Hung Kay Lee, Wai Kin Chan, Frederick C C Leung
We performed a comprehensive investigation of the toxicity of ZnO and TiO2 nanoparticles using Escherichia coli as a model organism. Both materials are wide band gap n-type semiconductors and they can interact with lipopolysaccharide molecules present in the outer membrane of E. coli, as well as produce reactive oxygen species (ROS) under UV illumination. Despite the similarities in their properties, the response of the bacteria to the two nanomaterials was fundamentally different. When the ROS generation is observed, the toxicity of nanomaterial is commonly attributed to oxidative stress and cell membrane damage caused by lipid peroxidation...
October 12, 2016: Scientific Reports
https://www.readbyqxmd.com/read/27709111/fluidic-logic-used-in-a-systems-approach-to-enable-integrated-single-cell-functional-analysis
#15
Naveen Ramalingam, Brian Fowler, Lukasz Szpankowski, Anne A Leyrat, Kyle Hukari, Myo Thu Maung, Wiganda Yorza, Michael Norris, Chris Cesar, Joe Shuga, Michael L Gonzales, Chad D Sanada, Xiaohui Wang, Rudy Yeung, Win Hwang, Justin Axsom, Naga Sai Gopi Krishna Devaraju, Ninez Delos Angeles, Cassandra Greene, Ming-Fang Zhou, Eng-Seng Ong, Chang-Chee Poh, Marcos Lam, Henry Choi, Zaw Htoo, Leo Lee, Chee-Sing Chin, Zhong-Wei Shen, Chong T Lu, Ilona Holcomb, Aik Ooi, Craig Stolarczyk, Tony Shuga, Kenneth J Livak, Marc Unger, Jay A A West
The study of single cells has evolved over the past several years to include expression and genomic analysis of an increasing number of single cells. Several studies have demonstrated wide spread variation and heterogeneity within cell populations of similar phenotype. While the characterization of these populations will likely set the foundation for our understanding of genomic- and expression-based diversity, it will not be able to link the functional differences of a single cell to its underlying genomic structure and activity...
2016: Frontiers in Bioengineering and Biotechnology
https://www.readbyqxmd.com/read/27704326/predictors-of-participation-in-an-ehealth-family-based-preventive-intervention-for-hispanic-youth
#16
Tatiana Perrino, Yannine Estrada, Shi Huang, Sara St George, Hilda Pantin, Miguel Ángel Cano, Tae Kyoung Lee, Guillermo Prado
The Familias Unidas intervention is an efficacious family-based preventive intervention for reducing substance use and other health risks among Hispanic youth. A current randomized controlled trial (RCT) is examining this intervention's efficacy when delivered via the Internet (eHealth). eHealth interventions can overcome logistical barriers to participation, yet there is limited information about the feasibility of these interventions, especially among ethnic minorities. This paper examines participation and predictors of participation in the eHealth Familias Unidas intervention in a sample of 113 Hispanic families whose adolescent had behavioral problems...
October 4, 2016: Prevention Science: the Official Journal of the Society for Prevention Research
https://www.readbyqxmd.com/read/27636550/a-european-spectrum-of-pharmacogenomic-biomarkers-implications-for-clinical-pharmacogenomics
#17
Clint Mizzi, Eleni Dalabira, Judit Kumuthini, Nduna Dzimiri, Istvan Balogh, Nazli Başak, Ruwen Böhm, Joseph Borg, Paola Borgiani, Nada Bozina, Henrike Bruckmueller, Beata Burzynska, Angel Carracedo, Ingolf Cascorbi, Constantinos Deltas, Vita Dolzan, Anthony Fenech, Godfrey Grech, Vytautas Kasiulevicius, Ľudevít Kádaši, Vaidutis Kučinskas, Elza Khusnutdinova, Yiannis L Loukas, Milan Macek, Halyna Makukh, Ron Mathijssen, Konstantinos Mitropoulos, Christina Mitropoulou, Giuseppe Novelli, Ioanna Papantoni, Sonja Pavlovic, Giuseppe Saglio, Jadranka Setric, Maja Stojiljkovic, Andrew P Stubbs, Alessio Squassina, Maria Torres, Marek Turnovec, Ron H van Schaik, Konstantinos Voskarides, Salma M Wakil, Anneke Werk, Maria Del Zompo, Branka Zukic, Theodora Katsila, Ming Ta Michael Lee, Alison Motsinger-Rief, Howard L Mc Leod, Peter J van der Spek, George P Patrinos
Pharmacogenomics aims to correlate inter-individual differences of drug efficacy and/or toxicity with the underlying genetic composition, particularly in genes encoding for protein factors and enzymes involved in drug metabolism and transport. In several European populations, particularly in countries with lower income, information related to the prevalence of pharmacogenomic biomarkers is incomplete or lacking. Here, we have implemented the microattribution approach to assess the pharmacogenomic biomarkers allelic spectrum in 18 European populations, mostly from developing European countries, by analyzing 1,931 pharmacogenomics biomarkers in 231 genes...
2016: PloS One
https://www.readbyqxmd.com/read/27634621/patient-reported-oral-health-outcome-measurement-for-children-and-adolescents
#18
Honghu Liu, Ron D Hays, Marvin Marcus, Ian Coulter, Carl Maida, Francisco Ramos-Gomez, Jie Shen, Yan Wang, Vladimir Spolsky, Steve Lee, Li Cai, James Crall
BACKGROUND: Oral health is an important component of daily functioning and well-being. A comprehensive patient-reported oral health measure is needed to gauge the impact of oral health status on children and adolescents. This study aims to develop oral health item banks and associated short-form surveys for children and adolescents 2-17 year olds. METHODS: Using children and adolescents, ages 2-17 years, selected from diverse dental sites in Greater Los Angeles Area, we propose to develop state-of-the-science methods to create oral health item banks to effectively measure oral health outcomes for children and adolescents...
September 15, 2016: BMC Oral Health
https://www.readbyqxmd.com/read/27618863/tissue-enrichment-analysis-for-c-elegans-genomics
#19
David Angeles-Albores, Raymond Y N Lee, Juancarlos Chan, Paul W Sternberg
BACKGROUND: Over the last ten years, there has been explosive development in methods for measuring gene expression. These methods can identify thousands of genes altered between conditions, but understanding these datasets and forming hypotheses based on them remains challenging. One way to analyze these datasets is to associate ontologies (hierarchical, descriptive vocabularies with controlled relations between terms) with genes and to look for enrichment of specific terms. Although Gene Ontology (GO) is available for Caenorhabditis elegans, it does not include anatomical information...
September 13, 2016: BMC Bioinformatics
https://www.readbyqxmd.com/read/27599383/nanocomposites-based-on-soluplus-and-angelica-gigas-nakai-extract-fabricated-by-an-electrohydrodynamic-method-for-oral-administration
#20
Jeong-Jun Lee, Suyeong Nam, Ju-Hwan Park, Song Yi Lee, Jae Young Jeong, Jae-Young Lee, Wie-Soo Kang, In-Soo Yoon, Dae-Duk Kim, Hyun-Jong Cho
Nanocomposites (NCs) based on Soluplus (SP) were fabricated by an electrohydrodynamic (EHD) method for the oral delivery of Angelica gigas Nakai (AGN). Nano-sized particles were obtained after dispersing the resultant, produced by the EHD technique, in the aqueous environment. AGN/SP2 (AGN:SP=1:2, w/w) NC dispersion in aqueous media exhibited a 130nm mean diameter, narrow size distribution, and robust stability in the tested concentration range of the ethanol extract of AGN (AGN EtOH ext) and at pH 1.2 and 6...
December 15, 2016: Journal of Colloid and Interface Science
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