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https://www.readbyqxmd.com/read/29753353/cost-effectiveness-of-a-technology-facilitated-depression-care-management-adoption-model-in-safety-net-primary-care-patients-with-type-2-diabetes
#1
Joel W Hay, Pey-Jiuan Lee, Haomiao Jin, Jeffrey J Guterman, Sandra Gross-Schulman, Kathleen Ell, Shinyi Wu
BACKGROUND: The Diabetes-Depression Care-Management Adoption Trial is a translational study of safety-net primary care predominantly Hispanic/Latino patients with type 2 diabetes in collaboration with the Los Angeles County Department of Health Services. OBJECTIVES: To evaluate the cost-effectiveness of an information and communication technology (ICT)-facilitated depression care management program. METHODS: Cost-effectiveness of the ICT-facilitated care (TC) delivery model was evaluated relative to a usual care (UC) and a supported care (SC) model...
May 2018: Value in Health: the Journal of the International Society for Pharmacoeconomics and Outcomes Research
https://www.readbyqxmd.com/read/29730885/adverse-events-associated-with-apremilast-use-and-withdrawal-for-psoriasis-in-a-real-world-setting
#2
Erica B Lee, Mina Amin, Alexander Egeberg, Jashin J Wu
Apremilast, a phosphodiesterase-4 inhibitor, is an oral therapy for treatment of psoriasis. Its safety profile is favorable, with side effects including diarrhea, nausea, vomiting, depression, and weight decrease, primarily based on clinical trial data. However, limited research exists on the side effect frequency and subsequent adverse events (AEs) in real-world practice. This retrospective chart review included patients who presented to the dermatology clinic at Kaiser Permanente Los Angeles Medical Center and were treated with apremilast at any time between January 1, 2015 and January 11, 2018...
May 6, 2018: Journal of the European Academy of Dermatology and Venereology: JEADV
https://www.readbyqxmd.com/read/29725737/genomic-scar-signatures-associated-with-homologous-recombination-deficiency-predict-adverse-clinical-outcomes-in-patients-with-ovarian-clear-cell-carcinoma
#3
Angel Chao, Chyong-Huey Lai, Tzu-Hao Wang, Shih-Ming Jung, Yun-Shien Lee, Wei-Yang Chang, Lan-Yang Yang, Fei-Chun Ku, Huei-Jean Huang, An-Shine Chao, Chin-Jung Wang, Ting-Chang Chang, Ren-Chin Wu
We investigated whether genomic scar signatures associated with homologous recombination deficiency (HRD), which include telomeric allelic imbalance (TAI), large-scale transition (LST), and loss of heterozygosity (LOH), can predict clinical outcomes in patients with ovarian clear cell carcinoma (OCCC). We enrolled patients with OCCC (n = 80) and high-grade serous carcinoma (HGSC; n = 92) subjected to primary cytoreductive surgery, most of whom received platinum-based adjuvant chemotherapy. Genomic scar signatures based on genome-wide copy number data were determined in all participants and investigated in relation to prognosis...
May 3, 2018: Journal of Molecular Medicine: Official Organ of the "Gesellschaft Deutscher Naturforscher und Ärzte"
https://www.readbyqxmd.com/read/29701699/simultaneous-determination-of-decursin-decursinol-angelate-nodakenin-and-decursinol-of-angelica-gigas-nakai-in-human-plasma-by-uhplc-ms-ms-application-to-pharmacokinetic-study
#4
Sook-Jin Kim, Se-Mi Ko, Eun-Jeong Choi, Seong-Ho Ham, Young-Dal Kwon, Yong-Bok Lee, Hea-Young Cho
Coumarins in Cham-dang-gwi, the dried root of Angelica gigas Nakai (AGN), possess pharmacological effects on anemia, pain, infection, and articular rheumatism. The AGN root containes decursin (D), decursinol angelate (DA), nodakenin, and decursinol (DOH), a major metabolite of D and DA. The aim of this study was to develop a simultaneous determination method for these four coumarins in human plasma using ultra high performance liquid chromatography-tandem mass spectrometry (UHPLC-MS/MS). Chromatographic separation was performed on dual columns (Kinetex® C18 column and Capcell core C18 column) with mobile phase consisting of water and acetonitrile at a flow rate of 0...
April 26, 2018: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
https://www.readbyqxmd.com/read/29691276/asia-pacific-working-group-consensus-on-non-variceal-upper-gastrointestinal-bleeding-an-update-2018
#5
Joseph Jy Sung, Philip Cy Chiu, Francis K L Chan, James Yw Lau, Khean-Lee Goh, Lawrence Hy Ho, Hwoon-Young Jung, Jose D Sollano, Takuji Gotoda, Nageshwar Reddy, Rajvinder Singh, Kentaro Sugano, Kai-Chun Wu, Chun-Yin Wu, David J Bjorkman, Dennis M Jensen, Ernst J Kuipers, Angel Lanas
Non-variceal upper gastrointestinal bleeding remains an important emergency condition, leading to significant morbidity and mortality. As endoscopic therapy is the 'gold standard' of management, treatment of these patients can be considered in three stages: pre-endoscopic treatment, endoscopic haemostasis and post-endoscopic management. Since publication of the Asia-Pacific consensus on non-variceal upper gastrointestinal bleeding (NVUGIB) 7 years ago, there have been significant advancements in the clinical management of patients in all three stages...
April 24, 2018: Gut
https://www.readbyqxmd.com/read/29685872/comparative-effectiveness-of-a-technology-facilitated-depression-care-management-model-in-safety-net-primary-care-patients-with-type-2-diabetes-6-month-outcomes-of-a-large-clinical-trial
#6
Shinyi Wu, Kathleen Ell, Haomiao Jin, Irene Vidyanti, Chih-Ping Chou, Pey-Jiuan Lee, Sandra Gross-Schulman, Laura Myerchin Sklaroff, David Belson, Arthur M Nezu, Joel Hay, Chien-Ju Wang, Geoffrey Scheib, Paul Di Capua, Caitlin Hawkins, Pai Liu, Magaly Ramirez, Brian W Wu, Mark Richman, Caitlin Myers, Davin Agustines, Robert Dasher, Alex Kopelowicz, Joseph Allevato, Mike Roybal, Eli Ipp, Uzma Haider, Sharon Graham, Vahid Mahabadi, Jeffrey Guterman
BACKGROUND: Comorbid depression is a significant challenge for safety-net primary care systems. Team-based collaborative depression care is effective, but complex system factors in safety-net organizations impede adoption and result in persistent disparities in outcomes. Diabetes-Depression Care-management Adoption Trial (DCAT) evaluated whether depression care could be significantly improved by harnessing information and communication technologies to automate routine screening and monitoring of patient symptoms and treatment adherence and allow timely communication with providers...
April 23, 2018: Journal of Medical Internet Research
https://www.readbyqxmd.com/read/29685837/outcomes-of-hip-arthroscopy-in-a-military-population-are-similar-to-those-in-the-civilian-population-matched-paired-analysis-at-2-years
#7
Jun-Il Yoo, Tae-Ho Lee, Jae-Yoon Kim, Jae-Hyung Kim, Yong-Chan Ha
PURPOSE: The purpose of this study was to compare the clinical outcomes, including the visual analog pain score, University of California Los Angeles activity, modified Harris hip score, and radiologic outcomes after hip arthroscopy in male patients whose symptoms developed during military services with those in a matched-pair control group of active young, nonmilitary patients at a minimum postoperative follow-up of 2 years. METHODS: From September 2009 to December 2014, 28 male patients with mechanical symptoms that developed during military service underwent hip arthroscopic surgery...
April 20, 2018: Arthroscopy: the Journal of Arthroscopic & related Surgery
https://www.readbyqxmd.com/read/29679116/arthroscopic-treatment-for-intratendinous-rotator-cuff-tear-results-in-satisfactory-clinical-outcomes-and-structural-integrity
#8
Sang Jin Cheon, Hyo Yeol Lee, Woong Ki Jeon
PURPOSE: This study aimed to evaluate the clinical outcomes and structural integrity of arthroscopic repair of intratendinous rotator cuff tear. METHODS: Patients who were diagnosed with an intratendinous tear but in whom conservative treatment failed were selected and underwent arthroscopic repair. Between 2008 and 2014, a total of 30 patients (6 men, 24 women; mean age, 59 ± 3.7 years) met the inclusion criteria and were followed up. The mean follow-up period was 26...
April 20, 2018: Knee Surgery, Sports Traumatology, Arthroscopy: Official Journal of the ESSKA
https://www.readbyqxmd.com/read/29676772/functional-roles-of-eriocalyxin-b-in-zebrafish-revealed-by-transcriptome-analysis
#9
Xunian Zhou, Cyanne Ye Cao, Angel Tsz-Yau Wan, Grace Gar-Lee Yue, Frankie Hin-Fai Kwok, Kwok-Pui Fung, Handong Sun, Clara Bik-San Lau, Pema-Tenzin Puno, Stephen Kwok-Wing Tsui
BACKGROUND: Eriocalyxin B (EriB) is a natural ent-kaurane diterpenoid obtained from Isodon eriocalyx var. laxiflora (family Lamiaceae), which has multiple biological activities (e.g. anti-tumor and anti-inflammatory) via the alteration of gene expression and signaling transduction. Recently, RNA sequencing (RNA-seq) has been developed as a dynamic transcriptome approach to analyze the transcriptional profile and in addition use such gene expression profiles to identify novel candidate genes in a zebrafish model...
April 20, 2018: Molecular omics
https://www.readbyqxmd.com/read/29675081/intra-fourth-ventricular-schwannoma-in-pediatric-age-group-report-of-second-case-in-the-western-literature-with-review-of-literature
#10
Luis Rafael Moscote-Salazar, Guru Dutta Satyarthee, Hector Farid-Escorcia, Willem Guillermo Calderon-Miranda, Huber Said Padilla-Zambrano, Angel Lee, Alfonso Pacheco-Hernandez, Amit Agrawal
Schwannoma originates from the myelin sheath of peripheral nerves. It accounts for about 8% of all intracranial tumors. Commonly, schwannoma is located in the extra-axial locations; intra-axial schwannomas are extremely uncommon. The schwannoma arising from fourth ventricle is extremely uncommon and authors in a detailed PubMed and MEDLINE search could find only seven cases reported in the literature in the form of isolated cases report, who were managed surgically, with only one being a pediatric case. Authors report second case of intra-fourth ventricular schwannoma occurring in the pediatric age group...
October 2017: Journal of Pediatric Neurosciences
https://www.readbyqxmd.com/read/29673672/associations-between-a-single-nucleotide-polymorphism-of-stress-induced-phosphoprotein-1-and-endometriosis-adenomyosis
#11
Chia-Lung Tsai, Yun-Shien Lee, Angel Chao, Chih-Feng Yen, Hsin-Shih Wang, Tzu-Hao Wang
OBJECTIVE: We have recently reported that stress-induced phosphoprotein 1 (STIP1) is over-expressed in endometriosis/adenomyosis tissues. STIP1 may also be involved in immune regulation, thus we attempted to study the association between STIP1 single nucleotide polymorphisms (SNPs) and endometriosis/adenomyosis. MATERIALS AND METHODS: Five STIP1 SNPs (rs7941773, rs2845597, rs4980524, rs2282490, and rs2236647) were selected for genotyping with matrix-assisted laser desorption ionization time-of-flight mass spectrometry (MALDI-TOF MS) in 286 patients with endometriosis/adenomyosis and 288 healthy postmenopausal controls...
April 2018: Taiwanese Journal of Obstetrics & Gynecology
https://www.readbyqxmd.com/read/29668852/meg-working-memory-n-back-task-reveals-functional-deficits-in-combat-related-mild-traumatic-brain-injury
#12
Ming-Xiong Huang, Sharon Nichols, Ashley Robb-Swan, Annemarie Angeles-Quinto, Deborah L Harrington, Angela Drake, Charles W Huang, Tao Song, Mithun Diwakar, Victoria B Risbrough, Scott Matthews, Royce Clifford, Chung-Kuan Cheng, Jeffrey W Huang, Anusha Sinha, Kate A Yurgil, Zhengwei Ji, Imanuel Lerman, Roland R Lee, Dewleen G Baker
Combat-related mild traumatic brain injury (mTBI) is a leading cause of sustained cognitive impairment in military service members and Veterans. However, the mechanism of persistent cognitive deficits including working memory (WM) dysfunction is not fully understood in mTBI. Few studies of WM deficits in mTBI have taken advantage of the temporal and frequency resolution afforded by electromagnetic measurements. Using magnetoencephalography (MEG) and an N-back WM task, we investigated functional abnormalities in combat-related mTBI...
April 13, 2018: Cerebral Cortex
https://www.readbyqxmd.com/read/29642925/atypical-traumatic-anterior-shoulder-instability-with-excessive-joint-laxity-recurrent-shoulder-subluxation-without-a-history-of-dislocation
#13
Sung-Jae Kim, Chong-Hyuk Choi, Yun-Rak Choi, Wonyong Lee, Woo-Seok Jung, Yong-Min Chun
BACKGROUND: No previously published studies have examined recurrent traumatic incomplete events in patients with excessive joint laxity. The purpose of this study is to investigate outcomes after arthroscopic stabilization for recurrent traumatic shoulder subluxation in patients with excessive joint laxity but no history of dislocation. METHODS: This study included 23 patients with glenoid bone defects less than 20% who underwent arthroscopic stabilization of recurrent shoulder subluxation and were available for at least 2 years follow-up...
April 11, 2018: Journal of Orthopaedic Surgery and Research
https://www.readbyqxmd.com/read/29626469/decursin-and-decursinol-angelate-improve-wound-healing-by-upregulating-transcription-of-genes-encoding-extracellular-matrix-remodeling-proteins-inflammatory-cytokines-and-growth-factors-in-human-keratinocytes
#14
Jisu Han, Wook Jin, Ngoc Anh Ho, Jeongpyo Hong, Yoon Ju Kim, Yungyeong Shin, Hanki Lee, Joo-Won Suh
The coumarins decursin and decursinol angelate, which are found in Angelica gigas Nakai, have a variety of biological functions. Here, we show that treatment with these compounds improves wound healing by HaCaT human keratinocytes. Wound healing was increased by treatment with up to a threshold concentration of decursin, decursinol angelate, a mixture of both, and a nano-emulsion of these compounds, but inhibited by treatment with higher concentrations. Immunoblotting and fluorescence imaging of cells expressing an epidermal growth factor receptor (EGFR) biosensor demonstrated that these compounds did not stimulate wound healing by inducing EGFR phosphorylation...
April 4, 2018: Biochemical and Biophysical Research Communications
https://www.readbyqxmd.com/read/29611407/radiographic-and-clinical-outcomes-of-robot-assisted-posterior-pedicle-screw-fixation-two-year-results-from-a-randomized-controlled-trial
#15
Sang Min Park, Ho Joong Kim, Se Yeon Lee, Bong Soon Chang, Choon Ki Lee, Jin S Yeom
PURPOSE: We prospectively assessed the early radiographic and clinical outcomes (minimum follow-up of 2 years) of robot-assisted pedicle screw fixation (Robot-PSF) and conventional freehand pedicle screw fixation (Conv-PSF). MATERIALS AND METHODS: Patients were randomly assigned to Robot-PSF (37 patients) or Conv-PSF (41 patients) for posterior interbody fusion surgery. The Robot-PSF group underwent minimally invasive pedicle screw fixation using a pre-planned robot-guided screw trajectory...
May 2018: Yonsei Medical Journal
https://www.readbyqxmd.com/read/29608957/asbmt-practice-guidelines-committee-survey-on-long-term-follow-up-clinics-for-hematopoietic-cell-transplant-survivors
#16
Shahrukh K Hashmi, Stephanie J Lee, Bipin N Savani, Linda Burns, John R Wingard, Miguel-Angel Perales, Jeanne Palmer, Eric Chow, Everett Meyer, David Marks, Mohamad Mohty, Yoshihiro Inamoto, Cesar Rodriguez, Arnon Nagler, Craig Sauter, Krishna V Komanduri, Joseph Pidala, Mehdi Hamadani, Laura Johnston, Nina Shah, Paul Shaughnessy, Betty K Hamilton, Navneet Majhail, Mohamed A Kharfan-Dabaja, Jeff Schriber, Zachariah DeFilipp, Katherine G Tarlock, Suzanne Fanning, Peter Curtin, J Douglas Rizzo, Paul A Carpenter
Significant advances in hematopoietic cell transplantation (HCT) have increased the long-term survivorship of its recipients, but because of unique complications arising from radiation and chemotherapy, recipients require lifelong follow-up. To evaluate current survivorship or long-term follow-up (LTFU) clinics specifically for HCT survivors and to evaluate the potential barriers in their establishment, the American Society for Blood and Marrow Transplantation (ASBMT) Practice Guidelines Committee electronically surveyed 200 HCT programs to gather quantitative and qualitative data about models of care...
March 30, 2018: Biology of Blood and Marrow Transplantation
https://www.readbyqxmd.com/read/29598855/role-of-percutaneous-coronary-intervention-in-the-treatment-of-cardiac-allograft-vasculopathy
#17
Michael S Lee, Gentian Lluri, Will Finch, Kyung Woo Park
We evaluated our quarter-century experience with percutaneous coronary intervention (PCI) in patients with cardiac allograft vasculopathy (CAV). CAV is a progressive form of atherosclerosis that is characterized by diffuse intimal thickening. It is a major cause of morbidity and mortality after orthotopic heart transplantation (OHT). Effective treatment options are limited. PCI has been used as a palliative treatment in selected patients. We retrospectively analyzed 140 patients with CAV who underwent PCI from 1992 to 2017 at the University of California, Los Angeles (UCLA) Medical Center...
February 6, 2018: American Journal of Cardiology
https://www.readbyqxmd.com/read/29581135/er-breast-cancers-resistant-to-prolonged-neoadjuvant-letrozole-exhibit-an-e2f4-transcriptional-program-sensitive-to-cdk4-6-inhibitors
#18
Angel Guerrero-Zotano, Thomas Stricker, Luigi Formisano, Katherine E Hutchinson, Daniel G Stover, Kyung-Min Lee, Luis J Schwarz, Jennifer M Giltnane, Monica V Estrada, Valerie M Jansen, Alberto Servetto, Joaquín Gavilá, José Alejandro Pérez-Fidalgo, Ana Lluch, Antonio Llombart-Cussac, Mohamed Amine Bayar, Stefan Michiels, Fabrice Andre, Monica Arnedos, Vicente Guillem, Amparo Ruiz-Simon, Carlos L Arteaga
PURPOSE: This study aimed to identify biomarkers of resistance to endocrine therapy in ER+ breast cancers (BC) treated with prolonged neoadjuvant letrozole. Experimental Design: We performed targeted DNA and RNA-sequencing in 68 ER+ BC from patients treated with preoperative letrozole (median 7 months). Results:Twenty-four tumors (35%) exhibited a PEPI score ≥4 and/or recurred after a median of 58 months and were considered endocrine resistant. Integration of the 47 most upregulated genes (log FC>1, FDR<0...
March 26, 2018: Clinical Cancer Research: An Official Journal of the American Association for Cancer Research
https://www.readbyqxmd.com/read/29579207/implementation-of-a-human-papillomavirus-screen-and-treat-model-in-mwanza-tanzania-training-local-healthcare-workers-for-sustainable-impact
#19
Megan Bernstein, Anjali Hari, Sahil Aggarwal, Debora Lee, Allison Farfel, Priya Patel, Kaavya Raman, Shella Raja, Reece Fenning, Mark Lieber, William Minteer, Sean Denny, Maureen Ries
Background: The purpose of this study is to evaluate the development of a 1-wk screening campaign and efforts towards the implementation of a sustainable system that addresses cervical cancer in Mwanza, Tanzania with a screen-and-treat model utilizing visual inspection of the cervix with acetic acid (VIA) and cryotherapy. Methods: In partnership with CureCervicalCancer (CCC), a non-profit organization based in Los Angeles, CA, USA, 11 medical students at the University of California, Irvine School of Medicine established a model for sustainable human papillomavirus screening practices in Mwanza, Tanzania...
March 22, 2018: International Health
https://www.readbyqxmd.com/read/29538590/analysis-of-ophthalmological-and-vision-related-publications-in-latin-america
#20
Lesly Carrillo Galván, Nadia Ríos, Van Charles Lansingh, Ángel Lee, Lihteh Wu, Ellery Lopez
PURPOSE: To assess scientific production related to ophthalmology and vision in Latin America during the period from 2006 to 2015. METHODS: The PubMed, Lilacs (Bireme), Google Scholar, SciELO, and Medigraphic databases were evaluated for this retrospective, descriptive, and comparative study. RESULTS: A total of 1,510 articles was identified. Brazil was the leader in quantitative production in ophthalmology, averaging 85.4 articles per year...
January 2018: Arquivos Brasileiros de Oftalmologia
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