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https://www.readbyqxmd.com/read/28921995/the-angel-and-the-devil-on-your-shoulder-friends-mitigate-and-exacerbate-21st-birthday-alcohol-related-consequences
#1
Jennifer Fillo, Lindsey M Rodriguez, Amber M Anthenien, Clayton Neighbors, Christine M Lee
Twenty-first birthdays are associated with heavier drinking and more negative consequences than any other high-risk drinking event. Friends are the strongest social influence on young adult drinking; however, previous research on college students' drinking has often only examined individuals' perceptions of "friends" generally. Unfortunately, this may obscure the positive influence of some friends and the negative influence of others. Using data drawn from a larger intervention study aimed at reducing 21st birthday drinking, this research examined how specific friends (N = 166) who were present at 21st birthday celebrations may have exacerbated or mitigated celebrants' (N = 166) experience of alcohol-related consequences, as well as how characteristics of that friendship moderate these effects...
September 18, 2017: Psychology of Addictive Behaviors: Journal of the Society of Psychologists in Addictive Behaviors
https://www.readbyqxmd.com/read/28910578/subjective-well-being-in-older-chinese-and-korean-immigrants-in-the-united-states-effects-of-self-rated-health-and-employment-status
#2
Bum Jung Kim, Hyeyoun Jun, Jisun Lee, Kristen Linton, Meehye Kim, Colette Browne
This study examined the effects of association between self-rated health and employment status on subjective well-being among older Chinese and Korean immigrants in the United States. Data were collected from 171 Chinese and 205 Korean older adult immigrants living in Los Angeles County. The primary variables included demographic data, subjective index of well-being, self-rated health, and employment status. Data support the association between self-rated health and subjective well-being for both groups. Employment, education, and age were associated with the level of subjective well-being only for older Korean immigrants...
September 14, 2017: Social Work in Public Health
https://www.readbyqxmd.com/read/28902074/plasma-tenofovir-levels-to-support-adherence-to-tdf-ftc-pre-exposure-prophylaxis-for-hiv-prevention-in-msm-in-los-angeles-california
#3
Raphael J Landovitz, Matthew Beymer, Ryan Kofron, K Rivet Amico, Christina Psaros, Lane Bushman, Peter L Anderson, Risa Flynn, David P Lee, Robert K Bolan, Wilbert C Jordan, Chi-Hong Tseng, Rhodri Dierst-Davies, Jim Rooney, Amy Rock Wohl
BACKGROUND: TDF/FTC PrEP is effective against rectal HIV acquisition when taken as prescribed. Strategies that identify and intervene with those challenged by adherence to daily medication are needed. SETTING: PATH-PrEP was an open-label single arm interventional cohort study conducted at 2 community-based clinical sites in Los Angeles, California. METHODS: We enrolled self-identified MSM and TGW ≥18 years of age at elevated risk of HIV acquisition...
September 7, 2017: Journal of Acquired Immune Deficiency Syndromes: JAIDS
https://www.readbyqxmd.com/read/28886514/fabrication-of-polymer-matrix-free-nanocomposites-based-on-angelica-gigas-nakai-extract-and-their-application-to-breast-cancer-therapy
#4
Song Yi Lee, Jeong-Jun Lee, Suyeong Nam, Wie-Soo Kang, In-Soo Yoon, Hyun-Jong Cho
Nanocomposites (NCs) based on the ethanol extract of Angelica gigas Nakai (AGN EtOH ext) were developed for breast cancer therapy. Polymer matrix-free nano-sized particles based on the extract of natural product were fabricated using a modified emulsification-solvent evaporation method. Without the use of polymer matrix, toxicity can be minimized and the clinical application may be assured. AGN NCs with approximately 200nm mean diameter, narrow size distribution, and negative zeta potential were prepared in this study...
August 26, 2017: Colloids and Surfaces. B, Biointerfaces
https://www.readbyqxmd.com/read/28876271/treatment-of-unstable-distal-clavicle-fractures-with-multiple-steinmann-pins-a-modification-of-neer-s-method-a-series-of-56-consecutive-cases
#5
Sang H Kwak, Young H Lee, Dong W Kim, Min B Kim, Ho S Choi, Goo H Baek
OBJECTIVES: To introduce an alternative fixation technique for Neer type II fractures using Steinmann pins (S-pins). DESIGN: Retrospective case series study. SETTING: Operating room followed by clinic in tertiary hospital. PATIENTS/PARTICIPANTS: Between 2001 and 2013, among 66 consecutive patients diagnosed with Neer type II distal clavicle fractures, 11 patients were excluded and 56 clavicles of 55 patients who underwent surgical treatment with multiple transacromial S-pins were selected for analysis...
September 2017: Journal of Orthopaedic Trauma
https://www.readbyqxmd.com/read/28874443/amelioration-of-diet-induced-steatohepatitis-in-mice-following-combined-therapy-with-aso-fsp27-and-fenofibrate
#6
Ananthi Rajamoorthi, Noemi Arias, Jeannine Basta, Richard G Lee, Ángel Baldán
Non-alcoholic fatty liver disease (NAFLD) is the leading cause of chronic liver disease. NAFLD progresses from benign steatosis to steatohepatitis (NASH) to cirrhosis, and is linked to hepatocellular carcinoma. No targeted treatment is currently approved for NAFLD/NASH. We showed that fat-specific protein 27 (FSP27), a lipid droplet-associated protein that controls triglyceride turnover in the hepatocyte, is required for fasting- and diet-induced triglyceride accumulation in the liver. However, silencing Fsp27 with antisense oligonucleotides (ASOs) did not improve hepatosteatosis in genetic nor nutritional mouse models of obesity...
September 5, 2017: Journal of Lipid Research
https://www.readbyqxmd.com/read/28864097/validating-the-11-item-revised-university-of-california-los-angeles-scale-to-assess-loneliness-among-older-adults-an-evaluation-of-factor-structure-and-other-measurement-properties
#7
Joonyup Lee, John G Cagle
OBJECTIVE: To examine the measurement properties and factor structure of the short version of the Revised University of California Los Angeles (R-UCLA) loneliness scale from the Health and Retirement Study (HRS). METHODS: Based on data from 3,706 HRS participants aged 65 + who completed the 2012 wave of the HRS and its Psychosocial Supplement, the measurement properties and factorability of the R-UCLA were examined by conducting an exploratory factor analysis (EFA) and the confirmatory factor analysis (CFA) on randomly split halves...
June 29, 2017: American Journal of Geriatric Psychiatry
https://www.readbyqxmd.com/read/28853676/hiv-aids-conspiracy-beliefs-and-intention-to-adopt-preexposure-prophylaxis-among-black-men-who-have-sex-with-men-in-los-angeles
#8
Ronald A Brooks, Vincent C Allen, Rotrease Regan, Matt G Mutchler, Ramon Cervantes-Tadeo, Sung-Jae Lee
In the United States, black men who have sex with men (MSM) are the group most affected by the HIV/AIDS epidemic. Pre-exposure prophylaxis (PrEP) is an important new HIV prevention strategy that may help reduce new HIV infections among black MSM. This analysis examined the association between HIV/AIDS conspiracy beliefs and intentions to adopt PrEP among 224 black MSM. The likelihood of adopting PrEP was assessed and more than half (60%) of the study population indicated a high intention to adopt PrEP. HIV/AIDS genocidal and treatment-related conspiracies were assessed using scales previously validated with black MSM...
January 1, 2017: International Journal of STD & AIDS
https://www.readbyqxmd.com/read/28852530/multidisciplinary-approach-to-manage-antenatally-suspected-placenta-percreta-updated-algorithm-and-patient-outcomes
#9
Paula S Lee, Samantha Kempner, Michael Miller, Jennifer Dominguez, Chad Grotegut, Jessie Ehrisman, Rebecca Previs, Laura J Havrilesky, Gloria Broadwater, Sarah C Ellestad, Angeles Alvarez Secord
BACKGROUND: Due to the significant morbidity and mortality associated with placenta percreta, alternative management options are needed. Beginning in 2005, our institution implemented a multidisciplinary strategy to patients with suspected placenta percreta. The purpose of this study is to present our current strategy, maternal morbidity and outcomes of patients treated by our approach. METHODS: From 2005 to 2014, a retrospective cohort study of patients with suspected placenta percreta at an academic tertiary care institution was performed...
2017: Gynecologic Oncology Research and Practice
https://www.readbyqxmd.com/read/28814131/what-factors-influence-women-s-perceptions-of-their-systemic-recurrence-risk-after-breast-cancer-treatment
#10
Kamaria L Lee, Nancy K Janz, Brian J Zikmund-Fisher, Reshma Jagsi, Lauren P Wallner, Allison W Kurian, Steven J Katz, Paul Abrahamse, Sarah T Hawley
BACKGROUND: Breast cancer patients' misunderstanding of their systemic cancer recurrence risk has consequences on decision-making and quality of life. Little is known about how women derive their risk estimates. METHODS: Using Los Angeles and Georgia's SEER registries (2014-2015), a random sample of early-stage breast cancer patients was sent surveys about 2 to 3 months after surgery ( N = 3930; RR, 68%). We conducted an inductive thematic analysis of open-ended responses about why women chose their risk estimates in a uniquely large sub-sample ( N = 1,754)...
August 1, 2017: Medical Decision Making: An International Journal of the Society for Medical Decision Making
https://www.readbyqxmd.com/read/28806093/critical-shoulder-angle-and-acromial-index-do-not-influence-24-month-functional-outcome-after-arthroscopic-rotator-cuff-repair
#11
Merrill Lee, Jerry Yongqian Chen, Ming Han Lincoln Liow, Hwei Chi Chong, Paul Chang, Denny Lie
BACKGROUND: Recent studies have shown a correlation between scapular geometry and the development of atraumatic rotator cuff tears. However, a paucity of literature is available on the effects of critical shoulder angle (CSA) and acromial index (AI) on functional outcomes after arthroscopic rotator cuff repair. Hypothesis/Purpose: The purpose was to investigate the influence of CSA and AI on 24-month functional outcomes after arthroscopic rotator cuff repair. The hypothesis was that a larger CSA or AI would result in poorer postoperative outcomes...
August 1, 2017: American Journal of Sports Medicine
https://www.readbyqxmd.com/read/28803710/intrathecal-2-hydroxypropyl-%C3%AE-cyclodextrin-decreases-neurological-disease-progression-in-niemann-pick-disease-type-c1-a-non-randomised-open-label-phase-1-2-trial
#12
Daniel S Ory, Elizabeth A Ottinger, Nicole Yanjanin Farhat, Kelly A King, Xuntian Jiang, Lisa Weissfeld, Elizabeth Berry-Kravis, Cristin D Davidson, Simona Bianconi, Lee Ann Keener, Ravichandran Rao, Ariane Soldatos, Rohini Sidhu, Kimberly A Walters, Xin Xu, Audrey Thurm, Beth Solomon, William J Pavan, Bernardus N Machielse, Mark Kao, Steven A Silber, John C McKew, Carmen C Brewer, Charles H Vite, Steven U Walkley, Christopher P Austin, Forbes D Porter
BACKGROUND: Niemann-Pick disease, type C1 (NPC1) is a lysosomal storage disorder characterised by progressive neurodegeneration. In preclinical testing, 2-hydroxypropyl-β-cyclodextrins (HPβCD) significantly delayed cerebellar Purkinje cell loss, slowed progression of neurological manifestations, and increased lifespan in mouse and cat models of NPC1. The aim of this study was to assess the safety and efficacy of lumbar intrathecal HPβCD. METHODS: In this open-label, dose-escalation phase 1-2a study, we gave monthly intrathecal HPβCD to participants with NPC1 with neurological manifestation at the National Institutes of Health (NIH), Bethesda, MD, USA...
August 10, 2017: Lancet
https://www.readbyqxmd.com/read/28748634/timing-of-births-and-oral-contraceptive-use-influences-ovarian-cancer-risk
#13
Anna H Wu, Celeste Leigh Pearce, Alice W Lee, Chiuchen Tseng, Anjali Jotwani, Prusha Patel, Malcolm C Pike
Increasing parity and duration of combined oral contraceptive (COC) use provide substantial protection against ovarian carcinoma (cancer). There are limited data on the impact of the age of the births or age of COC use on reducing ovarian cancer risk. Here, we examined the effects of age at first and last births and age at use of COCs using data from studies conducted in Los Angeles County, California, USA (1,632 cases, 2,340 controls). After adjusting for the number of births, every 5 years that a first birth was delayed reduced the risk of ovarian cancer by 13% (95% CI 5-21%; p = 0...
July 27, 2017: International Journal of Cancer. Journal International du Cancer
https://www.readbyqxmd.com/read/28747021/characteristics-and-outcomes-of-medically-managed-patients-with-non-st-segment-elevation-acute-coronary-syndromes-insights-from-the-multinational-epicor-asia-study
#14
Chee Tang Chin, Tiong K Ong, Rungroj Krittayaphong, Stephen W-L Lee, Jitendra P S Sawhney, Hyo-Soo Kim, Angeles Alonso Garcia, Héctor Bueno, Stuart J Pocock, Vo T Nhan, Ana Vega, Nobuya Hayashi, Yong Huo
BACKGROUND: Many patients with non-ST-segment elevation acute coronary syndromes (NSTE-ACS) are medically managed without coronary revascularization. The reasons vary and may impact prognosis. METHODS: EPICOR Asia (NCT01361386) is a prospective study of hospital survivors post-ACS enrolled in 218 hospitals from 8 countries/regions in Asia (06/2011-05/2012). All medically managed NSTE-ACS patients were classified into 3 groups: 1) no coronary angiography (CAG-); 2) non-significant coronary artery disease (CAD) on angiogram (CAG+ CAD-); and 3) significant CAD (CAG+ CAD+)...
September 15, 2017: International Journal of Cardiology
https://www.readbyqxmd.com/read/28712940/efficacy-pharmacokinetics-and-safety-of-the-biosimilar-ct-p10-compared-with-rituximab-in-patients-with-previously-untreated-advanced-stage-follicular-lymphoma-a-randomised-double-blind-parallel-group-non-inferiority-phase-3-trial
#15
Won Seog Kim, Christian Buske, Michinori Ogura, Wojciech Jurczak, Juan-Manuel Sancho, Edvard Zhavrid, Jin Seok Kim, José-Ángel Hernández-Rivas, Aliaksandr Prokharau, Mariana Vasilica, Rajinish Nagarkar, Dzhelil Osmanov, Larry W Kwak, Sang Joon Lee, Sung Young Lee, Yun Ju Bae, Bertrand Coiffier
BACKGROUND: Studies in patients with rheumatoid arthritis have shown that the rituximab biosimilar CT-P10 (Celltrion, Incheon, South Korea) has equivalent efficacy and pharmacokinetics to rituximab. In this phase 3 study, we aimed to assess the non-inferior efficacy and pharmacokinetic equivalence of CT-P10 compared with rituximab, when used in combination with cyclophosphamide, vincristine, and prednisone (CVP) in patients with newly diagnosed advanced-stage follicular lymphoma. METHODS: In this ongoing, randomised, double-blind, parallel-group, active-controlled study, patients aged 18 years or older with Ann Arbor stage III-IV follicular lymphoma were assigned 1:1 to CVP plus intravenous infusions of 375 mg/m(2) CT-P10 or rituximab on day 1 of eight 21-day cycles...
July 13, 2017: Lancet Haematology
https://www.readbyqxmd.com/read/28705694/rotator-cuff-bridging-repair-using-acellular-dermal-matrix-in-large-to-massive-rotator-cuff-tears-histologic-and-clinical-analysis
#16
Jong Ok Kim, Jong-Ho Lee, Kwang-Sup Kim, Jong-Hun Ji, Sung-Jun Koh, Jae-Ho Lee
BACKGROUND: This study investigated the efficacy of the bridging repair using an acellular dermal matrix (ADM) and an ADM with stem cells in rabbits. Also investigated were clinical outcomes of ADM bridging repair for large to massive rotator cuff tears. MATERIALS AND METHODS: ADM, with and without stem cells, was used to cover a 5- × 5-mm-sized cuff defect in 17 rabbits, and biomechanical, histologic, and immunohistochemical analyses were conducted. Also evaluated were 24 patients with large to massive rotator cuff tears after ADM bridging repair...
July 10, 2017: Journal of Shoulder and Elbow Surgery
https://www.readbyqxmd.com/read/28700428/prospective-evaluation-of-lymph-node-processing-at-staging-surgery-for-high-grade-endometrial-cancer
#17
Brittany A Davidson, Jessie Ehrisman, Sara Abbott, Zach Harmon, Angeles A Secord, Andrew Berchuck, Paula S Lee, Fidel A Valea, Xuechan Li, Laura J Havrilesky, Allison H S Hall
To determine whether the processing of additional adipose tissue collected during lymph node (LN) dissection results in the identification of additional LNs during endometrial cancer (EC) staging and to determine if the division of LNs into nodal basin-specific specimens has an effect on the number of LNs identified during EC staging. A prospective randomized controlled trial was performed on women with high-grade EC undergoing surgical staging. Subjects were randomized to collection of LNs into nodal basin-specific containers on the randomized side versus simple labeling on the nonrandomized side...
July 11, 2017: International Journal of Gynecological Pathology
https://www.readbyqxmd.com/read/28691487/low-temperature-ohmic-contact-to-monolayer-mos2-by-van-der-waals-bonded-co-h-bn-electrodes
#18
Xu Cui, En-Min Shih, Luis A Jauregui, Sang Hoon Chae, Young Duck Kim, Baichang Li, Dongjea Seo, Kateryna Pistunova, Jun Yin, Ji-Hoon Park, Heon-Jin Choi, Young Hee Lee, Kenji Watanabe, Takashi Taniguchi, Philip Kim, Cory R Dean, James C Hone
Monolayer MoS2, among many other transition metal dichalcogenides, holds great promise for future applications in nanoelectronics and optoelectronics due to its ultrathin nature, flexibility, sizable band gap, and unique spin-valley coupled physics. However, careful study of these properties at low temperature has been hindered by an inability to achieve low-temperature Ohmic contacts to monolayer MoS2, particularly at low carrier densities. In this work, we report a new contact scheme that utilizes cobalt (Co) with a monolayer of hexagonal boron nitride (h-BN) that has the following two functions: modifies the work function of Co and acts as a tunneling barrier...
July 18, 2017: Nano Letters
https://www.readbyqxmd.com/read/28687968/associations-between-obstructive-sleep-apnea-severity-and-endoscopically-proven-gastroesophageal-reflux-disease
#19
Youlim Kim, Yeon Joo Lee, Jong Sun Park, Young-Jae Cho, Ho Il Yoon, Jae Ho Lee, Choon-Taek Lee, Se Joong Kim
PURPOSE: Obstructive sleep apnea (OSA) is believed to be an important risk factor for gastroesophageal reflux disease (GERD). However, the association between OSA and GERD is not straightforward and has been incompletely characterized. The aim of this study was to assess the relationship between OSA and GERD by performing both polysomnography (PSG) and esophagogastroduodenoscopy (EGD). METHODS: The enrolled patients underwent both PSG and EGD from October 2003 to July 2015 at Seoul National University Bundang Hospital...
July 7, 2017: Sleep & Breathing, Schlaf & Atmung
https://www.readbyqxmd.com/read/28686734/reassessing-rainfall-in-the-luquillo-mountains-puerto-rico-local-and-global-ecohydrological-implications
#20
Sheila F Murphy, Robert F Stallard, Martha A Scholl, Grizelle González, Angel J Torres-Sánchez
Mountains receive a greater proportion of precipitation than other environments, and thus make a disproportionate contribution to the world's water supply. The Luquillo Mountains receive the highest rainfall on the island of Puerto Rico and serve as a critical source of water to surrounding communities. The area's role as a long-term research site has generated numerous hydrological, ecological, and geological investigations that have been included in regional and global overviews that compare tropical forests to other ecosystems...
2017: PloS One
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