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Irene Teo, Ratna Singh, Chetna Malhotra, Semra Ozdemir, Rebecca A Dent, Nesaretnam Barr Kumarakulasinghe, Wee Lee Yeo, Yin Bun Cheung, Rahul Malhotra, Ravindran Kanesvaran, Alethea Chung Pheng Yee, Noreen Chan, Huei Yaw Wu, Soh Mun Chin, Hum Yin Mei Allyn, Grace Meijuan Yang, Patricia Soek Hui Neo, Nivedita V Nadkarni, Richard Harding, Eric A Finkelstein
BACKGROUND: Advanced cancer significantly impacts quality of life of patients and families as they cope with symptom burden, treatment decision-making, uncertainty and costs of treatment. In Singapore, information about the experiences of advanced cancer patients and families and the financial cost they incur for end-of-life care is lacking. Understanding of this information is needed to inform practice and policy to ensure continuity and affordability of care at the end of life. The primary objectives of the Cost of Medical Care of Patients with Advanced Serious Illness in Singapore (COMPASS) cohort study are to describe changes in quality of life and to quantify healthcare utilization and costs of patients with advanced cancer at the end of life...
April 23, 2018: BMC Cancer
Han-Yee Neo, Hui-Ying Xu, Huei-Yaw Wu, Allyn Hum
OBJECTIVES: Prognostic challenges hinder the identification of patients with advanced chronic obstructive pulmonary disease (COPD) for timely palliative interventions. We postulate that a two-minute derivative (two-minute walking distance [2MWD]) of a standard six-minute walk test (6MWT) can identify frail subjects with poorer survival for early palliative intervention. The primary outcome of interest is mortality at 18 months. Secondary objectives include evaluation of the relationship between the 2MWD and ability to self-care, dyspnea-related disabilities, nutrition, forced expiratory volume in first second (FEV1), quality of life (QoL), and comorbidity burden...
August 2017: Journal of Palliative Medicine
Woan Shin Tan, Angel Lee, Sze Yee Yang, Susan Chan, Huei Yaw Wu, Charis Wei Ling Ng, Bee Hoon Heng
BACKGROUND: Terminally ill patients at the end-of-life do transit between care settings due to their complex care needs. Problems of care fragmentation could result in poor quality of care. AIM: We aimed to evaluate the impact of an integrated hospice home care programme on acute care service usage and on the share of home deaths. SETTINGS/PARTICIPANTS: The retrospective study cohort comprised patients who were diagnosed with cancer, had an expected prognosis of 1 year or less, and were referred to a home hospice...
July 2016: Palliative Medicine
Sharon Ng, Ching-Chun Lin, Suh-Fang Jeng, Yaw-Huei Hwang, Wu-Shiun Hsieh, Pau-Chung Chen
Methylmercury (MeHg) is a neurotoxicant and may have an adverse impact on child behavior. However, this impact was found to be inconsistent in fish-eating populations. Although the positive effects of the nutrients provided by a fish diet may overcome the effect of MeHg, the possibility of genetic variants influencing an individual's response to MeHg has also been discussed. The role of the Apolipoprotein E (APOE) epsilon 4 allele (ε4) on MeHg related neurotoxicity is still unclear. In the present study, we investigated the role of APOE variants in the relationship between cord blood mercury (Hg) and child behavior...
February 2015: Chemosphere
Kuan-Han Lin, Po-Ching Chu, Chun-Ya Kuo, Yaw-Huei Hwang, Shiao-Chi Wu, Yue Leon Guo
This study aimed to determine the incidence rates of psychiatric disorders within 1 year after occupational injury and to examine the association between occupational injury and the incidence of psychiatric disorders using National Health Insurance Research Database (NHIRD). We used cohort approach in this investigation. All eligible subjects were from the NHIRD, and aged 18-65 years old. A total of 542,208 patients were enrolled in this study. Among them, 1038 patients sustained occupational injury, 6891 patients sustained non-occupational injury...
November 30, 2014: Psychiatry Research
Allyn Hum Yin Mei, Wilson Low Cong Jin, Mervyn Koh Yong Hwang, Yee Choon Meng, Lee Chung Seng, Wu Huei Yaw
The purpose of this study was to evaluate the prognostic value of the Palliative Performance Scale (PPSv2) in the palliative care unit of our hospital, which sees more than 1500 referrals a year (both inpatient and outpatient). We evaluated 356 admission episodes into our department, focusing mainly on patients with advanced cancer. The PPS has been shown to be useful in prognostication and this study confirms this in a fairly large study population in a tertiary care, teaching hospital. We further evaluated the impact of certain biologic variables in survival length, and eventually looked at variables significant for survival at 90 days, developing a prognostic model incorporating these variables...
August 2013: Journal of Palliative Medicine
Yaw-Cheng Wang, Wen-Wei Sung, Lee Wang, Ya-Wen Cheng, Chih-Yi Chen, Tzu-Chin Wu, Shwn-Huey Shieh, Huei Lee
BACKGROUND: Polymorphisms (1082A>G, - 819C>T, and -592G>A) in the interleukin-10 (IL10) promoter are associated with its transcriptional activity. IL10 induction by cigarette smoking plays a role in smoking-related lung tumor progression. We therefore expected to find a difference in impact of IL10 haplotypes on overall survival (OS) and relapse-free survival (RFS) between squamous cell carcinomas (SCC) and adenocarcinomas (ADC) of lung. MATERIALS AND METHODS: Normal lung tissues adjacent to resected tumors from 439 lung cancer patients were collected to determine IL10 haplotypes (ATA and non-ATA) by direct sequencing and polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP)...
June 2013: Anticancer Research
Sharon Ng, Ching-Chun Lin, Yaw-Huei Hwang, Wu-Shiun Hsieh, Hua-Fang Liao, Pau-Chung Chen
The benefit of the nutritious elements in fish is insufficient for explaining the controversial finding regarding prenatal mercury (Hg) exposure and neurodevelopment; the varying frequency of susceptible genes among these populations may shed light on these observations. However, limited studies have been reported on the association between genetic susceptibility of prenatal Hg exposure and child development. Apolipoprotein E (APOE, protein; Apoe, gene) is a major protein transporter expressed in the brain...
July 2013: Neurotoxicology
Ching-Chun Lin, Yu-Chuan Chen, Feng-Chiao Su, Chien-Mu Lin, Hua-Fang Liao, Yaw-Huei Hwang, Wu-Shiun Hsieh, Suh-Fang Jeng, Yi-Ning Su, Pau-Chung Chen
BACKGROUND AND OBJECTIVE: Manganese, lead, arsenic and mercury are common neurotoxic metals in the environment. Nonetheless, the relationship between prenatal exposure to low doses of neurotoxic metals and neurodevelopment in children is not clear. The objective of this study was to explore the relationship between in utero exposure to environmental neurotoxic metals and neurodevelopment at 2 years of age. METHODS: The population of this study came from the Taiwan Birth Panel Study...
May 2013: Environmental Research
Yaw-Cheng Wang, Wen-Wei Sung, Tzu-Chin Wu, Lee Wang, Wen-Pin Chien, Ya-Wen Cheng, Chih-Yi Chen, Shwn-Huey Shieh, Huei Lee
IL-10 is associated with tumor malignancy via immune escape. We hypothesized that IL-10 haplotypes categorized by IL-10 promoter polymorphisms at -1082A>G, -819C>T, and -592C>A might influence IL-10 expression and give rise to non-small cell lung cancer (NSCLC) patients with poor outcomes and relapse. We collected adjacent normal tissues from 385 NSCLC patients to determine IL-10 haplotypes by direct sequencing and polymerase chain reaction restriction fragment length polymorphism (PCR-RFLP). Of the 385 tumors, 241 were available to evaluate IL-10 mRNA expression levels by real-time RT-PCR...
2012: PloS One
Ee-Yuee Chan, Huei-Yaw Wu, Yiong-Huak Chan
BACKGROUND: The Palliative Performance Scale (PPS) on admission is a predictor of survival. However, it is not highly discriminating for mid-range scores. 'PPS Change' between two time points considers the disease trajectory, and may improve the scale's utility. AIM: The aim of this study is to determine if a change in PPS scores between two significant time points predicts survival. DESIGN: This prospective cohort study examined 'Change on Admission', 'Change at Week 1', and 'Change at Week 2'...
April 2013: Palliative Medicine
Hsien-Jung Chen, Sin-Dai Wu, Zhe-Wei Lin, Guan-Jhong Huang, Yaw-Huei Lin
In this report a full-length cDNA, SPCAM, was isolated from ethephon-treated mature leaves of sweet potato. SPCAM contained 450 nucleotides (149 amino acids) in its open reading frame, and exhibited high amino acid sequence identities (ca. 76-100%) with several plant calmodulins, including Arabidopsis, carrot, ghost needle weed, pea, potato, soybean, sweet chestnut, and tobacco. Sweet potato SPCAM also contained four putative conserved calmodulin EF-hand motifs, which responded for Ca(2+) binding and cellular signalling...
March 15, 2012: Journal of Plant Physiology
Vivian Hsiu-Chuan Liao, Yu-Ju Chu, Yu-Chen Su, Po-Cheng Lin, Yaw-Huei Hwang, Chen-Wuing Liu, Chung-Min Liao, Fi-John Chang, Chan-Wei Yu
High levels of arsenic in groundwater and drinking water represent a major health problem worldwide. Drinking arsenic-contaminated groundwater is a likely cause of blackfoot disease (BFD) in Taiwan, but mechanisms controlling the mobilization of arsenic present at elevated concentrations within aquifers remain understudied. Microcosm experiments using sediments from arsenic contaminated shallow alluvial aquifers in the blackfoot disease endemic area showed simultaneous microbial reduction of Fe(III) and As(V)...
December 15, 2011: Journal of Hazardous Materials
Hsien-Jung Chen, Sin-Dai Wu, Guan-Jhong Huang, Che-Yu Shen, Mufidah Afiyanti, Wei-Jhen Li, Yaw-Huei Lin
In this report a full-length cDNA, SPCAT1, was isolated from ethephon-treated mature L3 leaves of sweet potato. SPCAT1 contained 1479 nucleotides (492 amino acids) in its open reading frame, and exhibited high amino acid sequence identities (ca. 71.2-80.9%) with several plant catalases, including Arabidopsis, eggplant, grey mangrove, pea, potato, tobacco and tomato. Gene structural analysis showed that SPCAT1 encoded a catalase and contained a putative conserved internal peroxisomal targeting signal PTS1 motif and calmodulin binding domain around its C-terminus...
January 1, 2012: Journal of Plant Physiology
Chia-Jung Hsieh, Wu-Shiun Hsieh, Yi-Ning Su, Hua-Fang Liao, Suh-Fang Jeng, Feng-Ming Taso, Yaw-Huei Hwang, Kuen-Yuh Wu, Chia-Yang Chen, Yueliang Leon Guo, Pau-Chung Chen
BACKGROUND: The Taiwan Birth Panel Study (TBPS) is a prospective follow-up study to investigate the development of child health and disease in relation to in-utero and/or early childhood environmental exposures. The rationale behind the establishment of such a cohort includes the magnitude of potential environmental exposures, the timing of exposure window, fatal and children's susceptibility to toxicants, early exposure delayed effects, and low-level or unknown neurodevelopmental toxicants...
August 12, 2011: BMC Research Notes
Yung-Chieh Tsao, Chang-Fu Wu, Pao-Erh Chang, Shin-Yu Chen, Yaw-Huei Hwang
This study evaluated the efficacy of simultaneously employing three open-path Fourier transform infrared (OP-FTIR) spectrometers with 3-day consecutive monitoring, using an odor episode as an example. The corresponding monitoring paths were allocated among the possible emission sources of a semiconductor manufacturing plant and the surrounding optoelectronic and electronic-related factories, which were located in a high-tech industrial park. There was a combined total odor rate of 43.9% for the three monitoring paths, each comprised of 736 continuous 5-minute monitoring records and containing detectable odor compounds, such as ammonia, ozone, butyl acetate, and propylene glycol monomethyl ether acetate (PGMEA)...
August 1, 2011: Science of the Total Environment
Ying-Ying Lin, Yue-Liang Leon Guo, Pau-Chung Chen, Jyung-Hung Liu, Hui-Chen Wu, Yaw-Huei Hwang
Although the anti-knocking agents used in Taiwan do not contain manganese, there are relatively high concentrations of the element in diesel fuel. As such, there have been many concerns about the impact of exposure to diesel fuels on health. This study was conducted in Taiwan to investigate the relationship between the concentration of manganese in cord blood of Taiwanese newborns and the geographic density of petrol stations as a surrogate for determining manganese emissions from vehicular traffic. A total of 1526 full-term newborns without major congenital malformations were consecutively recruited from various medical facilities from May 2004 to July 2005...
February 2011: Environmental Research
Allyn Hum, Angel Lee, Wu Huei Yaw
No abstract text is available yet for this article.
September 2009: Pain Research & Management: the Journal of the Canadian Pain Society
I-Jen Wang, Wu-Shiun Hsieh, Kuen-Yuh Wu, Yueliang Leon Guo, Yaw-Huei Hwang, Shiou-Hwa Jee, Pau-Chung Chen
The adverse impact of smoking on respiratory diseases and birth outcomes in children is well-known. However, the influence of smoke exposure including environmental tobacco smoke (ETS) and maternal smoking during pregnancy on atopic dermatitis (AD) is not clear. The purpose of this study was to evaluate the effect of gestational smoke exposure on the development of AD in the offspring on the basis of the maternal and cord blood cotinine. We recruited 261 mother and newborn pairs in 2004. Cord blood and information on perinatal factors of children were gathered at birth...
November 2008: Pediatric Allergy and Immunology
Yueh-Yun Yao, Keshab Lal Shrestha, Yue-Jin Wu, Huei-Ju Tasi, Chun-Chen Chen, Jinn-Moon Yang, Akikazu Ando, Chih-Yu Cheng, Yaw-Kuen Li
To obtain an enzyme for the production of chito-disaccharides (GlcN(2)) by converting endo-chitosanase to exo-chitosanase, we chose an endo-chitosanase from Bacillus circulans MH-K1 (Csn) as the candidate for protein engineering. Using molecular modeling, two peptides with five amino acids (PCLGG) and six amino acids (SRTCKP) were designed and inserted after the positions of D(115) and T(222) of Csn, respectively. The inserted fragments are expected to form loops that might protrude from opposite walls of the substrate-binding cleft, thus forming a 'roof' over the catalytic site that might alter the product specificity...
September 2008: Protein Engineering, Design & Selection: PEDS
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