Jérôme Bourgault, Erik Abner, Hasanga D Manikpurage, Natàlia Pujol-Gualdo, Triin Laisk, Émilie Gobeil, Eloi Gagnon, Arnaud Girard, Patricia L Mitchell, Sébastien Thériault, Tõnu Esko, Patrick Mathieu, Benoit J Arsenault
BACKGROUND & AIMS: Acute pancreatitis (AP) is a complex disease and the leading cause of gastrointestinal disease-related hospital admissions. Few therapeutic options exist for AP prevention. Blood proteins with causal evidence may represent promising drug targets, but few have been causally linked with AP. Our objective was to identify blood proteins linked with AP by combining genome-wide association meta-analysis and proteome-wide Mendelian randomization (MR) studies. METHODS: We performed a genome-wide association meta-analysis totalling 10,630 patients with AP and 844,679 controls and a series of inverse-variance weighted MR analyses using cis-acting variants on 4719 blood proteins from the deCODE study (N = 35,559) and 4979 blood proteins from the Fenland study (N = 10,708)...
May 2023: Gastroenterology