keyword
MENU ▼
Read by QxMD icon Read
search

Imid

keyword
https://www.readbyqxmd.com/read/28333391/high-performance-nonfullerene-polymer-solar-cells-based-on-imide-functionalized-wide-bandgap-polymers
#1
Baobing Fan, Kai Zhang, Xiao-Fang Jiang, Lei Ying, Fei Huang, Yong Cao
High-performance nonfullerene polymer solar cells (PSCs) are developed by integrating the nonfullerene electron-accepting material 3,9-bis(2-methylene-(3-(1,1-dicyanomethylene)-indanone))-5,5,11,11-tetrakis(4-hexylphenyl)-dithieno[2,3-d:2',3'-d']-s-indaceno[1,2-b:5,6-b']dithiophne) (ITIC) with a wide-bandgap electron-donating polymer PTzBI or PTzBI-DT, which consists of an imide functionalized benzotriazole (TzBI) building block. Detailed investigations reveal that the extension of conjugation can affect the optical and electronic properties, molecular aggregation properties, charge separation in the bulk-heterojunction films, and thus the overall photovoltaic performances...
March 23, 2017: Advanced Materials
https://www.readbyqxmd.com/read/28325256/how-have-evolutions-in-strategies-for-the-treatment-of-relapsed-refractory-multiple-myeloma-translated-into-improved-outcomes-for-patients
#2
REVIEW
Pieter Sonneveld, Edwin De Wit, Philippe Moreau
Although multiple myeloma (MM) remains incurable, the introduction of novel agents has improved clinical outcomes dramatically over the past 15 years. Response rates have risen from ∼30% with single agents to up to 90% with combination therapies. The immunomodulatory drugs (IMiDs) thalidomide and lenalidomide, and the proteasome inhibitor bortezomib, form the foundations for treatment of relapsed and/or refractory MM (RRMM). Newer agents, such as the IMiD pomalidomide, the histone deacetylase inhibitor panobinostat and the proteasome inhibitors carfilzomib and ixazomib, as well as the monoclonal antibodies daratumumab and elotuzumab, have further improved overall response rates in these patients...
April 2017: Critical Reviews in Oncology/hematology
https://www.readbyqxmd.com/read/28322511/controllable-self-assembly-of-amphiphilic-zwtterionic-pbi-towards-tunable-surface-wettability-of-the-nanostructures
#3
Meizhen Yin, Yong Ye, Baozhong Lü, Wenyu Cheng, Zhen Wu, Jie Wei
Amphiphilic molecules have obtained wide attentions for a few decades due to they possess both hydrophobic and hydrophilic properties, and can form diverse nanostructures in selective solvents. Herein, we report an asymmetric amphiphilic zwitterionic perylene bisimide (AZP) with an octyl chain and a zwitterionic group on the opposite imide positions of perylene tetracarboxylic dianhydride. The controllable nanostructures of AZP with tunable hydrophilic/hydrophobic surface have been investigated through solvent-dependent amphiphilic self-assembly as confirmed by SEM, TEM, and contact angle...
March 21, 2017: Chemistry, An Asian Journal
https://www.readbyqxmd.com/read/28314084/treatment-patterns-and-outcome-following-initial-relapse-or-refractory-disease-in-patients-with-systemic-light-chain-amyloidosis
#4
Nidhi Tandon, Surbhi Sidana, Morie A Gertz, Angela Dispenzieri, Martha Q Lacy, Francis K Buadi, David Dingli, Amie L Fonder, Miriam A Hobbs, Suzanne R Hayman, Wilson I Gonsalves, Yi Lisa Hwa, Prashant Kapoor, Robert A Kyle, Nelson Leung, Ronald S Go, John A Lust, Stephen J Russell, Steven R Zeldenrust, S Vincent Rajkumar, Shaji K Kumar
We analyzed the outcomes following initial relapse or refractory disease in systemic light chain amyloidosis (AL) and the impact of type of therapy employed.A total of 1327 patients with AL seen at Mayo Clinic within 90 days of diagnosis, between 2006 and 2015, were reviewed. The study included 366 patients experiencing a documented hematological or organ relapse or refractory disease requiring start of second line therapy. Overall survival (OS) and time to next treatment (TTNT) were calculated from start of second line treatment...
March 17, 2017: American Journal of Hematology
https://www.readbyqxmd.com/read/28306258/liquid-structure-of-bis-trifluoromethylsulfonyl-imide-based-ionic-liquids-assessed-by-ft-ir-spectroscopy
#5
Cassie Kimble, Christopher M Burba
Ionic liquids are a fertile and active area of research, in part, due to the unique properties these solvents offer over traditional molecular solvents. Since these properties are rooted in the fundamental ion-ion interactions that govern liquid structure, there is a strong motivation to characterize liquid structure. Infrared spectroscopy is a standard analytical tool for assessing the liquid structure, for the intramolecular vibrational modes of the composing the materials are often quite sensitive to the local environment about a given ion...
March 17, 2017: Journal of Physical Chemistry. B
https://www.readbyqxmd.com/read/28304029/convenient-preparation-of-4-diazoisochroman-3-imines-and-3-subsituted-3-5-dihydroisochromeno-3-4-d-1-2-3-triazoles
#6
Anni Ren, Ping Lu, Yanguang Wang
A novel and convenient preparation of 4-diazoisochroman-3-imines through the copper(i)-catalyzed cascade reaction of (2-ethynylphenyl)-methanols with sulfonyl azides is described. The synthesized cyclical α-diazo imidates could readily react with a variety of primary amines to furnish 3-substituted 3,5-dihydroisochromeno[3,4-d][1,2,3]-triazoles under catalyst-free conditions.
March 17, 2017: Chemical Communications: Chem Comm
https://www.readbyqxmd.com/read/28298557/chemical-approaches-to-targeted-protein-degradation-through-modulation-of-the-ubiquitin-proteasome-pathway
#7
REVIEW
Ian Collins, Hannah Wang, John J Caldwell, Raj Chopra
Manipulation of the ubiquitin-proteasome system to achieve targeted degradation of proteins within cells using chemical tools and drugs has the potential to transform pharmacological and therapeutic approaches in cancer and other diseases. An increased understanding of the molecular mechanism of thalidomide and its analogues following their clinical use has unlocked small-molecule modulation of the substrate specificity of the E3 ligase cereblon (CRBN), which in turn has resulted in the advancement of new immunomodulatory drugs (IMiDs) into the clinic...
March 15, 2017: Biochemical Journal
https://www.readbyqxmd.com/read/28298100/local-environment-structure-and-dynamics-of-co2-in-the-1-ethyl-3-methylimidazolium-bis-trifluoromethanesulfonyl-imide-and-related-ionic-liquids
#8
Tuanan C Lourenço, Santiago Aparicio, Gabriela C Costa, Luciano T Costa
Despite the innumerous papers regarding the study of the ionic liquids as a potential candidate for CO2 capture, many details concerning the structure and dynamics of CO2 in the system are still to be revealed, i.e., the correlation between the local environment structure and the dynamic properties of the substance. This present work relied on the performance of molecular dynamics both for the neat [C2mim][Tf2N] and [C2mim][Tf2N]/CO2 mixtures in an attempt to elucidate the local environment of CO2 and their effects on the dynamic properties of [C2mim][Tf2N]...
March 14, 2017: Journal of Chemical Physics
https://www.readbyqxmd.com/read/28290728/diffuse-large-b-cell-lymphoma-in-the-elderly-standard-treatment-and-new-perspectives
#9
Chiappella Annalisa, Alessia Castellino, Maura Nicolosi, Elisa Santambrogio, Umberto Vitolo
Diffuse large B-cell lymphoma (DLBCL) is the most common histotype in non Hodgkin lymphoma, with a peak incidence in the sixth decade. The standard treatment for elderly FIT DLBCL patients is Rituximab-CHOP; in unfit and frail patients, chemotherapy at reduced intensity should be considered. Areas covered: In this article, we will review use of standard therapies and new drugs investigated such as immonomudulating agents (IMiDs), Bruton Tyrosine Kinase (BTK), in fit, unfit, frail and very elderly DLCBL patients...
March 14, 2017: Expert Review of Hematology
https://www.readbyqxmd.com/read/28290455/fast-selective-homogeneous-extraction-of-uo2-2-with-carboxyl-functionalised-task-specific-ionic-liquids
#10
Yinyong Ao, Jian Chen, Min Xu, Jing Peng, Wei Huang, Jiuqiang Li, Maolin Zhai
The carboxyl-functionalised task-specific ionic liquid of 1-carboxymethyl-3-methylimidazolium bis(trifluoromethyl-sulfonyl)imide ([HOOCmim][NTf2]) was used as solvent and extractant for UO2(2+) extraction from aqueous solution. A homogeneous phase of [HOOCmim][NTf2]-H2O system could be achieved at 75 °C, and 86.8 ± 4.8% of UO2(2+) was separated from the aqueous solution after vibrating for only 1 min. Furthermore, nearly 97.3 ± 2.9% of UO2(2+) was stripped from [HOOCmim][NTf2] phase by 1 M HNO3 solution...
March 14, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28288514/a-reactive-pendant-mn-o-in-a-synthetic-structural-model-of-a-proposed-s4-state-in-the-photosynthetic-oxygen-evolving-complex
#11
Shivaiah Vaddypally, Sandeep K Kondaveeti, Santosh Karki, Megan M Van Vliet, Robert J Levis, Michael J Zdilla
The molecular mechanism of the Oxygen Evolving Center of photosystem II has been under debate for decades. One frequently cited proposal is the nucleophilic attack by water hydroxide on a pendant Mn=O moiety, though no chemical example of reactivity at a manganese cubane cluster has been reported. We describe here the preparation, characterization, and a reactivity study of a synthetic manganese cubane cluster with a pendant manganese-oxo moiety. Reaction of this cluster with alkenes results in oxygen and hydrogen atom transfer reactions to form alcohol- and ketone-based oxygen-containing products...
March 13, 2017: Journal of the American Chemical Society
https://www.readbyqxmd.com/read/28287522/a-simple-and-efficient-protocol-for-the-catalytic-insertion-polymerization-of-functional-norbornenes
#12
Basile Commarieu, Jonathan Potier, Moubarak Compaore, Raphael de Boever, Regis Imbeault, Jerome P Claverie
Norbornene can be polymerized by a variety of mechanisms, including insertion polymerization whereby the double bond is polymerized and the bicyclic nature of the monomer is conserved. The resulting polymer, polynorbornene, has a very high glass transition temperature, Tg, and interesting optical and electrical properties. However, the polymerization of functional norbornenes by this mechanism is complicated by the fact that the endo substituted norbornene monomer has, in general, a very low reactivity. Furthermore, the separation of the endo substituted monomer from the exo monomer is a tedious task...
February 27, 2017: Journal of Visualized Experiments: JoVE
https://www.readbyqxmd.com/read/28286889/water-and-hexane-in-an-ionic-liquid-computational-evidence-of-association-under-high-pressure
#13
A Mariani, R Caminiti, L Gontrani
High pressures may strongly affect the mesoscopic structure of some ionic liquids. In particular, the so called sponge-like structure is gradually destroyed when an increasing pressure is applied. Here we show how a polar solute, an apolar solute or a mixture thereof behave in the ionic liquid trihexyl, tetradecylphosphonium bis (trifluoromethyl-sulfonyl) imide when the pressure is raised up to 10 kbar. Our calculations clearly show an association between molecules that would not interact in ordinary conditions...
March 13, 2017: Physical Chemistry Chemical Physics: PCCP
https://www.readbyqxmd.com/read/28285807/a-brighter-side-to-thalidomide-its-potential-use-in-immunological-disorders
#14
REVIEW
David Millrine, Tadamitsu Kishimoto
Thalidomide and its derivatives are immunomodulatory drugs (IMiDs) known for their sedative, teratogenic, anti-angiogenic, and anti-inflammatory properties. Commonly used in the treatment of cancers such as multiple myeloma and myelodysplastic syndrome (MDS), IMiDs have also been used in the treatment of an inflammatory skin pathology associated with Hansen's disease/leprosy. They have also shown promise in the treatment of autoimmune disorders including systemic lupus erythmatosus (SLE) and inflammatory bowel disease (IBD)...
March 9, 2017: Trends in Molecular Medicine
https://www.readbyqxmd.com/read/28280825/tailoring-the-physical-properties-of-the-mixtures-of-ionic-liquids-a-microscopic-point-of-view
#15
O Palumbo, F Trequattrini, M A Navarra, J-B Brubach, P Roy, A Paolone
A detailed investigation of the phase diagram of the mixtures of the two ionic liquids N-trimethyl-N-propylammonium bis(trifluoromethylsulfonyl)imide (TMPA-TFSI) and N-trimethyl-N-hexylammonium bis(trifluoromethylsulfonyl)imide (TMHA-TFSI) has been performed in the temperature range between 140 and 330 K by means of DSC and infrared spectroscopy measurements. In the low temperature crystalline states, a large concentration of the trans-TFSI conformer is present in TMPA-TFSI, while almost only cis-TFSI is retained in TMHA-TFSI...
March 10, 2017: Physical Chemistry Chemical Physics: PCCP
https://www.readbyqxmd.com/read/28277672/linear-and-star-poly-ionic-liquid-assemblies-surface-monolayers-and-multilayers
#16
Andrew J Erwin, Weinan Xu, Hongkun He, Krzysztof Matyjaszewski, Vladimir V Tsukruk
The surface morphology and organization of poly(ionic liquid)s (PILs), poly[1-(4-vinylbenzyl)-3-butylimidazolium bis-(trifluoromethylsulfonyl)imide] (poly(VBBI+Tf2N-), are explored in conjunction to their molecular architecture, preparation conditions, and post-assembly treatments. The formation of stable PIL Langmuir and Langmuir-Blodgett (LB) monolayers at the air-water and air-solid interfaces is demonstrated. The hydrophobic Tf2N- is shown to be a critical agent governing assembly morphology, as observed in the reversible condensation of LB monolayers into dense nanodroplets...
March 9, 2017: Langmuir: the ACS Journal of Surfaces and Colloids
https://www.readbyqxmd.com/read/28273193/-drug-therapy-of-lymphomas
#17
Lajos Gergely
The therapy of lymphomas has undergone a major expansion during the last decade. Novel therapeutic targets have appeared beyond classical chemotherapeutic combinations. These novel drugs have very pronounced action across lymphoma types, and their toxicity profile is usually better tolerable compared to standard chemotherapies. These new therapies are enabling us to offer treatment to those patients who have refractory disease, and we had no option to treat them before these drugs. The author describes several new therapeutic options...
March 8, 2017: Magyar Onkologia
https://www.readbyqxmd.com/read/28272639/recent-advances-in-the-overman-rearrangement-synthesis-of-natural-products-and-valuable-compounds
#18
REVIEW
Rodney A Fernandes, Pullaiah Kattanguru, Sachin P Gholap, Dipali A Chaudhari
In the past decade, the Overman rearrangement, an important C-N bond forming reaction, has been intensely used in the synthesis of natural products, synthetic intermediates, building blocks and valuable compounds. This review documents the reports on this rearrangement reaction since 2005. The reaction has been tactfully used to introduce amine functionality in the synthesis of natural products. It is a one-pot process using the intermediate imidate which upon rearrangement generates the amide that can be hydrolysed to the amine...
March 8, 2017: Organic & Biomolecular Chemistry
https://www.readbyqxmd.com/read/28272370/intramolecular-hydrogen-bonding-involving-organic-fluorine-nmr-investigations-corroborated-by-dft-based-theoretical-calculations
#19
REVIEW
Sandeep Kumar Mishra, N Suryaprakash
The combined utility of many one and two dimensional NMR methodologies and DFT-based theoretical calculations have been exploited to detect the intramolecular hydrogen bond (HB) in number of different organic fluorine-containing derivatives of molecules, viz. benzanilides, hydrazides, imides, benzamides, and diphenyloxamides. The existence of two and three centered hydrogen bonds has been convincingly established in the investigated molecules. The NMR spectral parameters, viz., coupling mediated through hydrogen bond, one-bond NH scalar couplings, physical parameter dependent variation of chemical shifts of NH protons have paved the way for understanding the presence of hydrogen bond involving organic fluorine in all the investigated molecules...
March 7, 2017: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
https://www.readbyqxmd.com/read/28270368/clinical-outcomes-related-to-the-use-of-bendamustine-therapy-for-multiple-myeloma-patients-relapsed-refractory-to-imids-and-proteasome-inhibitors
#20
Fevzi Fırat Yalnız, Nihan Akkoç, Ayşe Salihoğlu, M Cem Ar, Seniz Aydın, A Emre Eşkazan, Teoman Soysal, Yıldız Aydın
Multiple myeloma (MM) patients who are relapsed or refractory to both proteasome inhibitory (PIs) and immunomodulatory drugs (IMiDs) have been reported to have poor outcome. Bendamustine has been reported to have an antitumor effect in newly diagnosed as well as relapsed refractory multiple myeloma (RRMM). The aim of this retrospective study was to evaluate the efficacy of bendamustine therapy in heavily pretreated MM patients, who were refractory to PIs and IMiDs. Nineteen RRMM patients treated either with bendamustine and steroid (n=13) or a combination of bendamustine in with novel drugs (n=6) were included...
March 8, 2017: Turkish Journal of Haematology: Official Journal of Turkish Society of Haematology
keyword
keyword
55911
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"