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https://www.readbyqxmd.com/read/29356268/chiral-stable-thermally-activated-delayed-fluorescence-enantiomers-for-highly-efficient-oleds-with-circularly-polarized-electroluminescence
#1
Chuan-Feng Chen, Meng Li, Si-Hua Li, Dongdong Zhang, Minghan Cai, Lian Duan, Man-Keung Fung
A couple of chiral aromatic imide based TADF enantiomers (+)-(S,S)-CAI-Cz and (-)-(R,R)-CAI-Cz were efficiently synthesized by introducing chiral 1,2-diaminocyclohexane into achiral TADF unit. The TADF enantiomers exhibited high PLQY of up to 98 %, small ∆EST of 0.06 eV, as well as obvious temperature-dependent transient PL spectra, demonstrating their excellent TADF properties. Moreover, the TADF enantiomers with optical stabilities also showed mirror-image CD and CPL activities. Especially, the CP-OLEDs with CPEL properties based on the TADF enantiomers not only achieved high EQE of up to 19...
January 22, 2018: Angewandte Chemie
https://www.readbyqxmd.com/read/29355016/anisotropic-ion-diffusion-and-electrochemically-driven-transport-in-nanostructured-block-copolymer-electrolytes
#2
Ksenia Timachova, Irune Villaluenga, Lisa Cirrincione, Mallory Gobet, Rajashree Bhattacharya, Xi Jiang, John Newman, Louis A Madsen, Steven G Greenbaum, Nitash P Balsara
Nanostructured block copolymer electrolytes have the potential to enable solid-state batteries with lithium metal anodes. We present complete continuum characterization of ion transport in a lamellar polystyrene-b-poly(ethylene oxide) copolymer/lithium bis(trifluoromethanesulfonyl)imide (LiTFSI) electrolyte as a function of salt concentration. Electrochemical measurements are used to determine the Stefan-Maxwell salt diffusion coefficients [Formula: see text], [Formula: see text], and [Formula: see text]. Individual self-diffusion coefficients of the lithium- and TFSI-containing species were measured by pulsed-field gradient NMR (PFG-NMR)...
January 22, 2018: Journal of Physical Chemistry. B
https://www.readbyqxmd.com/read/29353127/physical-comorbidities-increase-the-risk-of-psychiatric-comorbidity-in-immune-mediated-inflammatory-disease
#3
Ruth Ann Marrie, Randy Walld, James M Bolton, Jitender Sareen, John R Walker, Scott B Patten, Alexander Singer, Lisa M Lix, Carol A Hitchon, Renée El-Gabalawy, Alan Katz, John D Fisk, Charles N Bernstein
OBJECTIVE: We tested the association between physical comorbidity and incident depression, anxiety disorder and bipolar disorder in three immune-mediated inflammatory diseases (IMID): inflammatory bowel disease (IBD), multiple sclerosis (MS) and rheumatoid arthritis (RA) versus age-, sex- and geographically-matched controls. METHODS: Using population-based administrative data we identified 6119 persons with IBD, 3514 persons with MS, 10,206 persons with RA and 97,727 matched controls...
January 11, 2018: General Hospital Psychiatry
https://www.readbyqxmd.com/read/29352782/communication-investigation-of-ion-aggregation-in-ionic-liquids-and-their-solutions-with-lithium-salt-under-high-pressure
#4
Kartik Pilar, Victor Balédent, Mehdi Zeghal, Patrick Judeinstein, Sangsik Jeong, Stefano Passerini, Steve Greenbaum
X-ray scattering measurements were utilized to probe the effects of pressure on a series of ionic liquids, N-alkyl-N-methyl-pyrrolidinium bis(trifluoromethanesulfonyl)imide (Pyr1A-TFSI) (A = 3, 6, and 9), along with mixtures of ionic liquid and 30 mol. % lithium bis(trifluoromethanesulfonyl)imide (LiTFSI) salt. No evidence was found for crystallization of the pure ionic liquids or salt mixtures even at pressures up to 9.2 GPa. No phase separation or demixing was observed for the ionic liquid and salt mixtures...
January 21, 2018: Journal of Chemical Physics
https://www.readbyqxmd.com/read/29351993/fluorine-donating-electrolytes-enable-highly-reversible-5-v-class-li-metal-batteries
#5
Liumin Suo, Weijiang Xue, Mallory Gobet, Steve G Greenbaum, Chao Wang, Yuming Chen, Wanlu Yang, Yangxing Li, Ju Li
Lithium metal has gravimetric capacity ∼10× that of graphite which incentivizes rechargeable Li metal batteries (RLMB) development. A key factor that limits practical use of RLMB is morphological instability of Li metal anode upon electrodeposition, reflected by the uncontrolled area growth of solid-electrolyte interphase that traps cyclable Li, quantified by the Coulombic inefficiency (CI). Here we show that CI decreases approximately exponentially with increasing donatable fluorine concentration of the electrolyte...
January 19, 2018: Proceedings of the National Academy of Sciences of the United States of America
https://www.readbyqxmd.com/read/29348877/role-of-irf4-in-resistance-to-immunomodulatory-imid-compounds%C3%A2-in-waldenstr%C3%A3-m-s-macroglobulinemia
#6
Elisabeth Bertrand, Nathalie Jouy, Salomon Manier, Guillemette Fouquet, Stéphanie Guidez, Eileen Boyle, Stéphanie Noel, Cécile Tomowiak, Charles Herbaux, Susanna Schraen, Claude Preudhomme, Bruno Quesnel, Stéphanie Poulain, Xavier Leleu
Background: Immunomodulatory drugs, IMid compounds, are active in Waldenström's macroglobulinemia (WM), although in a lesser extent than multiple myeloma, where it was initially developed. We hypothesized WM tumour cells might develop mechanisms of resistance, and sought to identify and describe these mechanisms. Material and Method: MM and WM-derived cell lines, and Waldenström's CD19+ cells were treated using both lenalidomide and pomalidomide. Stable CRBN expressing cells were generated...
December 22, 2017: Oncotarget
https://www.readbyqxmd.com/read/29346274/irf4-mediates-the-oncogenic-effects-of-stat3-in-anaplastic-large-cell-lymphomas
#7
Cecilia Bandini, Aldi Pupuleku, Elisa Spaccarotella, Elisa Pellegrino, Rui Wang, Nicoletta Vitale, Carlotta Duval, Daniela Cantarella, Andrea Rinaldi, Paolo Provero, Ferdinando Di Cunto, Enzo Medico, Francesco Bertoni, Giorgio Inghirami, Roberto Piva
Systemic anaplastic large cell lymphomas (ALCL) are a category of T-cell non-Hodgkin's lymphomas which can be divided into anaplastic lymphoma kinase (ALK) positive and ALK negative subgroups, based on ALK gene rearrangements. Among several pathways aberrantly activated in ALCL, the constitutive activation of signal transducer and activator of transcription 3 (STAT3) is shared by all ALK positive ALCL and has been detected in a subgroup of ALK negative ALCL. To discover essential mediators of STAT3 oncogenic activity that may represent feasible targets for ALCL therapies, we combined gene expression profiling analysis and RNA interference functional approaches...
January 18, 2018: Cancers
https://www.readbyqxmd.com/read/29345695/erratum-kini-bailur-j-mehta-s-zhang-l-et-al-changes-in-bone-marrow-innate-lymphoid-cell-subsets-in-monoclonal-gammopathy-target-for-imid-therapy-blood-adv-2017-1-25-2343-2347
#8
(no author information available yet)
[This corrects the article DOI: 10.1182/bloodadvances.2017012732.].
January 9, 2018: Blood Advances
https://www.readbyqxmd.com/read/29343461/effects-of-psychiatric-comorbidity-in-immune-mediated-inflammatory-disease-protocol-for-a-prospective-study
#9
Ruth Ann Marrie, Lesley Graff, John R Walker, John D Fisk, Scott B Patten, Carol A Hitchon, Lisa M Lix, James Bolton, Jitender Sareen, Alan Katz, Lindsay I Berrigan, James J Marriott, Alexander Singer, Renée El-Gabalawy, Christine A Peschken, Ryan Zarychanski, Charles N Bernstein
BACKGROUND: Immune-mediated inflammatory diseases (IMID), such as inflammatory bowel disease (IBD), multiple sclerosis (MS), and rheumatoid arthritis (RA), are highly prevalent in Canada and the United States and result in substantial personal and societal burden. The prevalence of psychiatric comorbidities, primarily depression and anxiety, in IMID exceeds those in the general population by two- to threefold, but remains underdiagnosed and undertreated. Furthermore, the effects of psychiatric comorbidity on IMID are not well understood...
January 17, 2018: JMIR Research Protocols
https://www.readbyqxmd.com/read/29340393/ferrocenyl-sulfonium-ionic-liquids-synthesis-characterization-and-electrochemistry
#10
Alexander Venker, Tobias Vollgraff, Jörg Sundermeyer
New ferrocenylsulfonium cation based ionic liquids were prepared by direct alkylation of the corresponding ferrocenyl-based thioethers with N-alkylbis(trifluoromethanesulfonyl)imides (R'TFSI). This convenient direct access to organometallic sulfonium bis(trifluoromethanesulfonyl)imide (TFSI) salts without the need for ion exchange was chosen in order to obtain highly pure and reversibly redox active room temperature ILs in many cases. In other cases the anion cation interaction in the solid state was studied by XRD analyses...
January 17, 2018: Dalton Transactions: An International Journal of Inorganic Chemistry
https://www.readbyqxmd.com/read/29337389/thiazole-imide-based-all-acceptor-homopolymer-achieving-high-performance-unipolar-electron-transport-in-organic-thin-film-transistors
#11
Yongqiang Shi, Han Guo, Minchao Qin, Jiuyang Zhao, Yuxi Wang, Hang Wang, Yulun Wang, Antonio Facchetti, Xinhui Lu, Xugang Guo
High-performance unipolar n-type polymer semiconductors are critical for advancing the field of organic electronics, which relies on the design and synthesis of new electron-deficient building blocks with good solubilizing capability, favorable geometry, and optimized electrical properties. Herein, two novel imide-functionalized thiazoles, 5,5'-bithiazole-4,4'-dicarboxyimide (BTzI) and 2,2'-bithiazolothienyl-4,4',10,10'-tetracarboxydiimide (DTzTI), are successfully synthesized. Single crystal analysis and physicochemical study reveal that DTzTI is an excellent building block for constructing all-acceptor homopolymers, and the resulting polymer poly(2,2'-bithiazolothienyl-4,4',10,10'-tetracarboxydiimide) (PDTzTI) exhibits unipolar n-type transport with a remarkable electron mobility (μe ) of 1...
January 16, 2018: Advanced Materials
https://www.readbyqxmd.com/read/29334375/a-small-molecule-inhibitor-of-the-ubiquitin-activating-enzyme-for-cancer-treatment
#12
Marc L Hyer, Michael A Milhollen, Jeff Ciavarri, Paul Fleming, Tary Traore, Darshan Sappal, Jessica Huck, Judy Shi, James Gavin, Jim Brownell, Yu Yang, Bradley Stringer, Robert Griffin, Frank Bruzzese, Teresa Soucy, Jennifer Duffy, Claudia Rabino, Jessica Riceberg, Kara Hoar, Anya Lublinsky, Saurabh Menon, Michael Sintchak, Nancy Bump, Sai M Pulukuri, Steve Langston, Stephen Tirrell, Mike Kuranda, Petter Veiby, John Newcomb, Ping Li, Jing Tao Wu, Josh Powe, Lawrence R Dick, Paul Greenspan, Katherine Galvin, Mark Manfredi, Chris Claiborne, Benjamin S Amidon, Neil F Bence
The ubiquitin-proteasome system (UPS) comprises a network of enzymes that is responsible for maintaining cellular protein homeostasis. The therapeutic potential of this pathway has been validated by the clinical successes of a number of UPS modulators, including proteasome inhibitors and immunomodulatory imide drugs (IMiDs). Here we identified TAK-243 (formerly known as MLN7243) as a potent, mechanism-based small-molecule inhibitor of the ubiquitin activating enzyme (UAE), the primary mammalian E1 enzyme that regulates the ubiquitin conjugation cascade...
January 15, 2018: Nature Medicine
https://www.readbyqxmd.com/read/29333596/risk-of-adverse-events-associated-with-front-line-anti-myeloma-treatment-in-medicare-patients-with-multiple-myeloma
#13
Ying Chen, David R Lairson, Wenyaw Chan, Xianglin L Du
This study aims to examine the risks of adverse events associated with anti-multiple myeloma (MM) therapies in a large population-based cohort of elderly patients with MM. Patients diagnosed with advanced MM from 2005 through 2009 and receiving anti-MM therapy were identified from the Surveillance, Epidemiology, and End Results (SEER)-Medicare-linked data. We compared safety outcomes between novel agents (proteasome inhibitor (PI) and immunomodulatory drugs (IMiD)) and other therapies and between PI- or IMiD-based regimens and PI plus IMiD combination regimens...
January 15, 2018: Annals of Hematology
https://www.readbyqxmd.com/read/29328507/genetics-of-immune-mediated-inflammatory-diseases
#14
REVIEW
Trixy David, Stephanie Ling, Anne Barton
Immune-mediated inflammatory diseases (IMIDs) are characterised by dysregulation of the normal immune response, which leads to inflammation. Together, they account for a high disease burden in the population, given that they are usually chronic conditions with associated co-morbidities. Examples include systemic lupus erythematosus, rheumatoid arthritis, Crohn's disease and type 1 diabetes. Since the advent of genome-wide association studies, evidence of considerable genetic overlap in the loci predisposing to a wide range of IMIDs has emerged...
January 12, 2018: Clinical and Experimental Immunology
https://www.readbyqxmd.com/read/29327935/introduction-of-a-crystalline-shelf-stable-reagent-for-the-synthesis-of-sulfur-vi-fluorides
#15
Hua Zhou, Paramita Mukherjee, Rongqiang Liu, Edelweiss Evrard, Dianpeng Wang, John M Humphrey, Todd W Butler, Lise R Hoth, Jeffrey B Sperry, Sylvie K Sakata, Christopher J Helal, Christopher W Am Ende
The design, synthesis, and application of [4-(acetylamino)phenyl]imidodisulfuryl difluoride (AISF), a shelf-stable, crystalline reagent for the synthesis of sulfur(VI) fluorides, is described. The utility of AISF is demonstrated in the synthesis of a diverse array of aryl fluorosulfates and sulfamoyl fluorides under mild conditions. Additionally, a single-step preparation of AISF was developed that installed the bis(fluorosulfonyl)imide group on acetanilide utilizing an oxidative C-H functionalization protocol...
January 12, 2018: Organic Letters
https://www.readbyqxmd.com/read/29324345/synthesis-and-biological-evaluation-of-a-series-of-multi-target-n-substituted-cyclic-imide-derivatives-with-potential-antipsychotic-effect
#16
Mingshuo Xu, Yu Wang, Feipu Yang, Chunhui Wu, Zhen Wang, Bin Ye, Xiangrui Jiang, Qingjie Zhao, Jianfeng Li, Yongjian Liu, Junchi Zhang, Guanghui Tian, Yang He, Jingshan Shen, Hualiang Jiang
In the present study, a series of multi-target N-substituted cyclic imide derivatives which possessed potent dopamine D2, serotonin 5-HT1A and 5-HT2A receptors properties were synthesized and evaluated as potential antipsychotics. Among these compounds, (3aR,4R,7S,7aS)-2-(4-(4-(benzo[b]thiophen-4-yl)piperazin-1-yl)butyl)-3a,4,7,7a-tetrahydro-1H-4,7-methanoisoindole-1,3(2H)-dione hydrochloride (3d) held a promising pharmacological profile. 3d not only showed potent and balanced in vitro activities on D2/5-HT1A/5-HT2A receptors, but also endowed with low to moderate activities on 5-HT2C, H1, α1A, M3 receptors and hERG channel, suggesting a low liability to induce side effects such as weight gain, orthostatic hypotension and QT prolongation...
January 4, 2018: European Journal of Medicinal Chemistry
https://www.readbyqxmd.com/read/29320191/synthesis-of-2-aminoimidazolones-and-imidazolones-by-3-2-annulation-of-azaoxyallyl-cations
#17
Maria C DiPoto, Jimmy Wu
The first examples of (3 + 2) annulations between azaoxyallyl cations and cyanamides and nitriles to give the corresponding 2-aminoimidazolones and imidazolones are reported. On the basis of the isolation of unexpected imidate products with certain substrates, it is proposed that the reaction proceeds via fast kinetic O-alkylation followed by rearrangement to the thermodynamically favored 2-aminoimidazolones and imidazolones. The method was applied to the formal synthesis of the antihypertensive drug irbesartan...
January 10, 2018: Organic Letters
https://www.readbyqxmd.com/read/29319089/on-the-coordination-of-zn2-ion-in-tf2n-based-ionic-liquids-structural-and-dynamic-properties-depending-on-the-nature-of-the-organic-cation
#18
Francesco Sessa, Valentina Migliorati, Alessandra Serva, Andrea Lapi, Giuliana Aquilanti, Giordano Mancini, Paola D'Angelo
A synergic approach combining molecular dynamics (MD) simulations and X-ray absorption spectroscopy has been used to investigate diluted solutions of zinc bis(trifluoromethanesulfonyl)imide (Zn(Tf2N)2) in Tf2N- based ionic liquids (ILs) having different organic cations, namely the 1-butyl-3-methylimidazolium ([C4(mim)]+), 1,8-bis(3-methylimidazolium-1-yl)octane ([C8(mim)2]2+), N,N,N-trimethyl-N-(2-hydroxyethyl)ammonium ([Choline]+) and butyltrimethylammonium ([BTMA]+) ions. All of the ILs tend to dissolve the Zn(Tf2N)2 species giving rise to a different structural arrangement around the Zn2+ as compared to that of the salt crystallographic structure...
January 10, 2018: Physical Chemistry Chemical Physics: PCCP
https://www.readbyqxmd.com/read/29318675/toward-an-aqueous-solar-battery-direct-electrochemical-storage-of-solar-energy-in-carbon-nitrides
#19
Filip Podjaski, Julia Kröger, Bettina V Lotsch
Graphitic carbon nitrides have emerged as an earth-abundant family of polymeric materials for solar energy conversion. Herein, a 2D cyanamide-functionalized polyheptazine imide (NCN-PHI) is reported, which for the first time enables the synergistic coupling of two key functions of energy conversion within one single material: light harvesting and electrical energy storage. Photo-electrochemical measurements in aqueous electrolytes reveal the underlying mechanism of this "solar battery" material: the charge storage in NCN-PHI is based on the photoreduction of the carbon nitride backbone and charge compensation is realized by adsorption of alkali metal ions within the NCN-PHI layers and at the solution interface...
January 10, 2018: Advanced Materials
https://www.readbyqxmd.com/read/29310879/fracture-analysis-of-cad-cam-high-density-polymers-used-for-interim-implant-supported-fixed-cantilevered-prostheses
#20
Burak Yilmaz, Gülce Alp, Jeremy Seidt, William M Johnston, Roger Vitter, Edwin A McGlumphy
STATEMENT OF PROBLEM: The load-to-fracture performance of computer-assisted design and computer-assisted manufacturing (CAD-CAM) high-density polymer (HDP) materials in cantilevers is unknown. PURPOSE: The purposes of this in vitro study were to evaluate the load-to-fracture performance of CAD-CAM-fabricated HDPs and to compare that with performance of autopolymerized and injection-molded acrylic resins. MATERIAL AND METHODS: Specimens from 8 different brands of CAD-CAM HDPs, including Brylic Solid (BS); Brylic Gradient (BG); AnaxCAD Temp EZ (AE); AnaxCAD Temp Plus (AP); Zirkonzahn Temp Basic (Z); GDS Tempo-CAD (GD); Polident (Po); Merz M-PM-Disc (MAT); an autopolymerized acrylic resin, Imident (Conv) and an injection-molded acrylic resin, SR-IvoBase High Impact (Inj) were evaluated for load-to-fracture analysis (n=5)...
January 5, 2018: Journal of Prosthetic Dentistry
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