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https://www.readbyqxmd.com/read/28214336/evidence-to-show-that-acetonitrile-is-sensitive-to-different-interactions-sites-of-ionic-liquids-as-unveiled-by-excess-spectroscopy
#1
Yu Zhou, Yan-Zhen Zheng, Tian Zhang, Geng Deng, Zhi-Wu Yu
By studying the interactions between an ionic liquid (IL), 1-ethyl-3-methylimidazolium bis (trifluoromethylsulfonyl) imide ([Emim][Tf2N]) and a co-solvent acetonitrile, C≡N stretching vibration was found to be very sensitive to different interaction sites as unveiled by excess infrared spectroscopy. Four existing forms of acetonitrile molecules were identified and the detailed transformation process of the ionic liquid upon dilution was obtained. Such characteristic of nitrile group is discussed from the view point of its ability to form hydrogen bonds with proton donors...
February 18, 2017: Chemphyschem: a European Journal of Chemical Physics and Physical Chemistry
https://www.readbyqxmd.com/read/28212336/the-influence-of-anion-shape-on-the-electrical-double-layer-microstructure-and-capacitance-of-ionic-liquids-based-supercapacitors-by-molecular-simulations
#2
Ming Chen, Song Li, Guang Feng
Room-temperature ionic liquids (RTILs) are an emerging class of electrolytes for supercapacitors. In this work, we investigate the effects of different supercapacitor models and anion shape on the electrical double layers (EDLs) of two different RTILs: 1-ethyl-3-methylimidazolium bis(trifluoromethanesulfonyl)imide ([Emim][Tf₂N]) and 1-ethyl-3-methylimidazolium 2-(cyano)pyrrolide ([Emim][CNPyr]) by molecular dynamics (MD) simulation. The EDL microstructure is represented by number densities of cations and anions, and the potential drop near neutral and charged electrodes reveal that the supercapacitor model with a single electrode has the same EDL structure as the model with two opposite electrodes...
February 16, 2017: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
https://www.readbyqxmd.com/read/28211054/real-world-use-of-pomalidomide-and-dexamethasone-in-double-refractory-multiple-myeloma-suggests-benefit-in-renal-impairment-and-adverse-genetics-a-multi-centre-uk-experience
#3
Nicola Maciocia, Andrew Melville, Simon Cheesman, Faye Sharpley, Karthik Ramasamy, Matthew Streetly, Matthew Jenner, Reuben Benjamin, Steve Schey, Paul Maciocia, Rakesh Popat, Shirley D'sa, Ali Rismani, Aviva Cerner, Kwee Yong, Neil Rabin
Myeloma patients who become refractory to immunomodulatory agents (IMiDs) and bortezomib have poor survival, with limited therapeutic options. Pomalidomide has shown improved survival and good tolerability in this patient cohort in clinical trials, but real world data are scarce. We retrospectively analysed all patients treated with pomalidomide at five UK centres between 2013 and 2016. Of 85 patients identified, 70 had sufficient information for response assessments. Median age was 66 years [40-89], 96·5% were refractory to IMiDs, 72·9% were refractory to both an IMiD and bortezomib and 92·9% were refractory to their last treatment...
February 17, 2017: British Journal of Haematology
https://www.readbyqxmd.com/read/28205024/immunomodulatory-drugs-in-multiple-myeloma-mechanisms-of-action-and-clinical-experience
#4
REVIEW
Sarah A Holstein, Philip L McCarthy
Over the last two decades, the outcomes for patients with multiple myeloma, a plasma cell malignancy, have dramatically improved. The development of the immunomodulatory drugs (IMiDs), which include thalidomide, lenalidomide, and pomalidomide, has contributed significantly to these improved outcomes. While thalidomide is now less commonly prescribed, lenalidomide is widely used in the treatment of newly diagnosed transplant-eligible and transplant-ineligible patients, in the maintenance setting post-transplant and in the relapsed/refractory setting, while pomalidomide is currently utilized in the relapsed/refractory setting...
February 16, 2017: Drugs
https://www.readbyqxmd.com/read/28203342/optimizing-current-and-emerging-therapies-in-multiple-myeloma-a-guide-for-the-hematologist
#5
REVIEW
Shahzad Raza, Rachael A Safyan, Evan Rosenbaum, Alex S Bowman, Suzanne Lentzsch
Multiple myeloma (MM) is the second most common hematologic malignancy. The diagnosis of MM requires ⩾10% clonal plasma cells in the bone marrow or biopsy-proven plasmacytoma, plus evidence of end-organ damage (hypercalcemia, renal failure, anemia, and lytic bone lesions). The definition of MM has recently been expanded to include a ⩾60% clonal plasma cell burden in the bone marrow, serum involved/uninvolved light chain ratio of ⩾100, or more than one focal lesion on magnetic resonance imaging ⩾5 mm in the absence of end-organ damage...
February 2017: Therapeutic Advances in Hematology
https://www.readbyqxmd.com/read/28201977/targeting-the-immune-niche-within-the-bone-marrow-microenvironment-the-rise-of-immunotherapy-in-multiple-myeloma
#6
Klaus Podar, D Jäger
Multiple Myeloma (MM) cells inhibit the development of an effective anti-MM immune response via defects in T cell function, ineffective antigen presentation; reduced phagocytic capacity; natural killer and dendritic cell dysfunction; decreased responsiveness to IL-2 and defects in B cell immunity; upregulation of inhibitory pathways; and production of excessive pro-inflammatory cytokines. Moreover, immune cells including plasmacytoid dendritic cells and macrophages trigger tumor cell proliferation, survival, and drug resistance...
February 13, 2017: Current Cancer Drug Targets
https://www.readbyqxmd.com/read/28201976/immunomodulatory-drugs-imids-in-multiple-myeloma
#7
Shahzad Raza, Rachael A Safyan, Lentzsch Suzanne
Multiple myeloma (MM) is a plasma cell neoplasm that is incurable with conventional therapy. However, the treatment of MM has dramatically changed since the emergence of immunomodulatory drugs and proteasome inhibitors. The improvements in survival are linked to a deeper understanding of the molecular mechanisms of the disease. Thalidomide, although highly active in MM, is associated with considerable toxicity, particularly in older patients. Immunomodulatory drugs (IMiDs) are structural and functional analogues of thalidomide that represent a promising new class of immunomodulators for treatment of a variety of inflammatory, autoimmune, and neoplastic diseases...
February 13, 2017: Current Cancer Drug Targets
https://www.readbyqxmd.com/read/28199049/towards-organic-zeolites-and-inclusion-catalysts-heptazine-imide-salts-can-exchange-metal-cations-in-the-solid-state
#8
Markus Antonietti, Aleksandr Savateev, Sergey Pronkin, Marc Willinger, Dariya Dontsova
Highly crystalline potassium (heptazine imides) were prepared by the thermal condensation of substituted 1,2,4-triazoles in eutectic salt melts. These semiconducting salts are already known to be highly active photocatalysts, e.g. for the visible light driven generation of hydrogen from water. Herein, we show that within the solid state structure, potassium ions can be exchanged to other metal ions while the crystal habitus is essentially preserved.
February 15, 2017: Chemistry, An Asian Journal
https://www.readbyqxmd.com/read/28198593/electrochemical-behavior-of-pedot-lignin-in-ionic-liquid-electrolytes-suitable-cathode-electrolyte-system-for-sodium-batteries
#9
Nerea Casado, Matthias Hilder, Cristina Pozo-Gonzalo, Maria Forsyth, David Mecerreyes
Biomass derived polymers, such as lignin, contain redox quinone/hydroquinone redox moieties that can be used to store charge. Composites based on the biopolymer lignin and several conjugated polymers have shown good charge storage properties. However, their performance has been just studied in acidic aqueous media limiting the applications mainly to supercapacitors. Here we show that PEDOT/Lignin biopolymers are electroactive in aprotic ionic liquids and we move a step further by assembling sodium full cell batteries using PEDOT/Lignin as electrode material and ionic liquid electrolytes...
February 15, 2017: ChemSusChem
https://www.readbyqxmd.com/read/28198064/real-life-practices-for-preventing-venous-thromboembolism-in-multiple-myeloma-patients-a-cohort-study-from-the-french-health-insurance-database
#10
Aurore Palmaro, Marie-Eve Rougé-Bugat, Martin Gauthier, Fabien Despas, Guillaume Moulis, Maryse Lapeyre-Mestre
PURPOSE: The risk of venous thromboembolic event (VTE) in multiple myeloma is particularly increased. Current guidelines recommend systematic VTE prophylaxis with vitamin K antagonists (VKA) or low weight molecular heparin (LWMH) or unfractionated heparin (UFH) in high-risk patients, based on treatment received [e.g. use of IMiDs (thalidomide, lenalidomide and pomalidomide), alkylating agents or erythropoietin] and individual risk factors (e.g. history of VTE). The aim of this study was to describe strategy of VTE prophylaxis and prescribing of other antithrombotic agents during the first 6 months of multiple myeloma therapy, with stratification on IMiD-based regimens and drug and disease-related risk factors...
February 15, 2017: Pharmacoepidemiology and Drug Safety
https://www.readbyqxmd.com/read/28196305/soft-wet-chemical-synthesis-of-metastable-superparamagnetic-nickel-hcp-nanoparticles-in-different-ionic-liquids
#11
Christina Rutz, Kai Schütte, Juri Barthel, Alexey Bushmelev, Annette Schmidt, Katharina Dilchert, Roland Fischer, Christoph Janiak
The microwave-induced decomposition of bis{N,N'-diisopropylacetamidinate}nickel(II) [Ni{MeC(NiPr)2}2] or bis(1,5-cyclooctadiene)nickel(0) [Ni(COD)2] in imidazolium-, pyridinium- or thiophenium-based ionic liquids with different anions (tetrafluoroborate, [BF4]-, hexafluorophosphate, [PF6]- and bis(trifluoromethylsulfonyl)imide, [NTf2]-) yields small, uniform nickel nanoparticles (Ni-NPs) which are stable in the absence of capping ligands (surfactants) for more than eight weeks. The soft wet-chemical synthesis yield the metastable Ni(hcp) and not the stable Ni(fcc) phase...
February 14, 2017: Chemistry: a European Journal
https://www.readbyqxmd.com/read/28193026/detection-of-sub-ppm-concentrations-of-ammonia-in-an-ionic-liquid-enhanced-current-density-using-filled-recessed-microarrays
#12
Ghulam Hussain, Debbie S Silvester
The voltammetric detection of less than 1 ppm of ammonia gas in the room temperature ionic liquid (RTIL) 1-ethyl-3-methylimidazolium bis(trifluoromethylsulfonyl)imide ([C2mim][NTf2]) is demonstrated using low-cost planar electrode devices. Three commercially available planar devices were employed, all with platinum (Pt) working electrodes: a thin-film electrode (TFE), a screen-printed electrode (SPE), and a microarray thin film electrode (MATFE), along with an "ideal" conventional Pt microdisk electrode for comparison...
December 20, 2016: Analytical Chemistry
https://www.readbyqxmd.com/read/28186721/ionic-liquid-as-reaction-medium-for-synthesis-of-hierarchically-structured-one-dimensional-moo2-for-efficient-hydrogen-evolution
#13
Baohua Zhang, Yiguo Xue, Anning Jiang, Zhimin Xue, Zhonghao Li, Jingcheng Hao
Hierarchically structured one-dimensional (1D) MoO2 is synthesized for the first time in ionic liquid 1-butyl-3-methylimidazolium bis(trifluoromethanesulfonyl)imide ([BMIM][Tf2N]). The synthesis system is very simple (single [BMIM][Tf2N] solvent plus MoO2(acac)2 reactant). [BMIM][Tf2N] itself works as both the reaction medium and the template for the formation of these interesting 1D MoO2 particles with ultrathin nanosheet subunits. The as-synthesized hierarchically 1D MoO2_40 particles exhibit remarkable electrocatalytic activity with good long-term cycle stability for the hydrogen evolution reaction (HER) in acidic media...
February 17, 2017: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/28168517/reversible-absorption-and-emission-responses-of-nile-blue-and-azure-a-derivatives-in-extreme-acidic-and-basic-conditions
#14
Xiu-Li Wang, Ru Sun, Wei-Jin Zhu, Xin-Long Sha, Jian-Feng Ge
Oxazinium derivatives have recently played an important role in bioanalysis attributing to the distinguished properties, thus a detailed study of the structure-property relationship is especially significant. Herein, pH-sensitive optical properties of Nile Blue (1a), N-monoalkyl-Nile Blue (1b) and Azure A (1c) have been carried out in extreme acid and base conditions. Dyes 1a and 1c showed colorimetric changes by the protonation of nitrogen atom in strong acidic condition (pH < 2.0), and dyes 1a - c exhibited colorimetric changes by equilibrium between amino and imide groups in very strong basic case (pH > 7...
February 6, 2017: Journal of Fluorescence
https://www.readbyqxmd.com/read/28162821/safety-of-live-vaccinations-on-immunosuppressive-therapy-in-patients-with-immune-mediated-inflammatory-diseases-solid-organ-transplantation-or-after-bone-marrow-transplantation-a-systematic-review-of-randomized-trials-observational-studies-and-case-reports
#15
REVIEW
Evelina Croce, Christoph Hatz, Emile F Jonker, L G Visser, Veronika K Jaeger, Silja Bühler
BACKGROUND: Live vaccines are generally contraindicated on immunosuppressive therapy due to safety concerns. However, data are limited to corroborate this practice. OBJECTIVES: To estimate the safety of live vaccinations in patients with immune-mediated inflammatory diseases (IMID) or solid organ transplantation (SOT) on immunosuppressive treatment and in patients after bone-marrow transplantation (BMT). DATA SOURCES: A search was conducted in electronic databases (Cochrane, Pubmed, Embase) and additional literature was identified by targeted searches...
February 2, 2017: Vaccine
https://www.readbyqxmd.com/read/28161252/synthesis-and-biological-evaluation-of-cyclic-imides-incorporating-benzenesulfonamide-moieties-as-carbonic-anhydrase-i-ii-iv-and-ix-inhibitors
#16
Alaa A-M Abdel-Aziz, Andrea Angeli, Adel S El-Azab, Mohamed A Abu El-Enin, Claudiu T Supuran
A group of cyclic imides was synthesized by reaction of amino-substituted benzenesulfonamides with a series of acid anhydrides such as succinic, maleic, tetrahydrophthalic, pyrazine-2,3-dicarboxylic acid anhydride, and substituted phthalic anhydrides. The synthesized sulfonamides were evaluated as carbonic anhydrase (CA, EC 4.2.1.1) inhibitors against the human (h) isoforms hCA I, II, IV and IX, involved in a variety of diseases among which glaucoma, retinitis pigmentosa, etc. Some of these sulfonamides showed effective inhibitory action (in the nanomolar range) against the cytosolic isoform hCA II and the transmembrane, tumor-associated one hCA IX, making them interesting candidates for preclinical evaluation in glaucoma or various tumors in which the two enzymes are involved...
January 24, 2017: Bioorganic & Medicinal Chemistry
https://www.readbyqxmd.com/read/28154372/therapeutic-effect-of-the-immunomodulatory-drug-lenalidomide-but-not-pomalidomide-in-experimental-models-of-rheumatoid-arthritis-and-inflammatory-bowel-disease
#17
Belen Lopez-Millan, Rafael Diaz de la Guardia, Heleia Roca-Ho, Carmen M García-Herrero, Jessie R Lavoie, Michael Rosu-Myles, Elena Gonzalez-Rey, Francisco O'Valle, Gabriel Criado, Mario Delgado, Pablo Menendez
Thalidomide is an immunomodulatory drug (IMiD) with proven therapeutic action in several autoimmune/inflammatory diseases; however, its inherent high toxicity has led to the development of more powerful and safer thalidomide analogs, including lenalidomide and pomalidomide. These are new generation IMiDs that exhibit direct antitumor activity as well as anti-inflammatory/immunomodulatory properties, and are FDA-approved for the treatment of several hematological malignances. Here we investigated the potential therapeutic effects of lenalidomide and pomalidomide in several experimental murine models of autoimmune/inflammatory diseases: 2,4,6-trinitrobenzene sulfonic acid- and dextran sulfate sodium-induced inflammatory bowel disease and type II collagen-induced arthritis...
February 3, 2017: Experimental & Molecular Medicine
https://www.readbyqxmd.com/read/28146355/5d-metal-iv-imide-complexes-the-impact-or-lack-thereof-of-d-orbital-occupation-on-methane-activation-and-functionalization
#18
Catherine A Moulder, Thomas R Cundari
This research evaluates 5d metal imide complexes, (OH)2M═NMe (M = W, Re, or Os), and their reactions with methane to form dimethylamine. Each is calculated to follow a consistent reaction pathway regardless of the metal's d-orbital occupation, whereby the methane C-H bond undergoes oxidative addition (OA) to the metal and then the methyl migrates from the metal to the nitrogen to form an amide. Finally, hydrogen migrates to the nitrogen before dissociating to form amine products. While homolytic M-imide, M-amide M-H, and M-CH3 bond dissociation free energies (BDFEs) were analyzed, the BDFEs of neither hexavalent nor tetravalent metal moieties reflect the oxidative addition kinetics...
February 20, 2017: Inorganic Chemistry
https://www.readbyqxmd.com/read/28144661/manganese-containing-ionic-liquids-synthesis-crystal-structures-and-electrodeposition-of-manganese-films-and-nanoparticles
#19
Jeroen Sniekers, João C Malaquias, Luc Van Meervelt, Jan Fransaer, Koen Binnemans
Manganese(ii)-containing ionic liquids were synthesized, in which the manganese atoms are coordinated by glymes (diglyme, triglyme, tetraglyme), pyridine-N-oxide, dimethylsulfoxide or N-alkylimidazoles (N-methylimidazole, N-butylimidazole and N-hexylimidazole). As anion, bis(trifluoromethanesulfonyl)imide (bistriflimide, Tf2N(-)), trifluoromethanesulfonate (triflate, OTf(-)) or methanesulfonate (mesylate, OMs(-)) were used. The compounds were characterized by CHN analysis, FTIR, DSC and single-crystal X-ray diffraction measurements...
February 1, 2017: Dalton Transactions: An International Journal of Inorganic Chemistry
https://www.readbyqxmd.com/read/28140567/tuning-the-interplay-between-selectivity-and-permeability-of-zif-7-mixed-matrix-membranes
#20
Bassem A Al-Maythalony, Ahmed M Alloush, Muhammed Faizan, Hatim Dafallah, Mohammed A A Elgzoly, Adam A A Seliman, Amir Al-Ahmed, Zain H Yamani, Mohamed A M Habib, Kyle E Cordova, Omar M Yaghi
Nanoparticles of zeolitic imidazolate framework-7 (nZIF-7) were blended with poly(ether imide) (PEI) to fabricate a new mixed-matrix membrane (nZIF-7/PEI). nZIF-7 was chosen in order to demonstrate the power of postsynthetic modification (PSM) by linker exchange of benzimidazolate to benzotriazolate for tuning the permeability and selectivity properties of a resulting membrane (PSM-nZIF-7/PEI). These two new membranes were subjected to constant volume, variable pressure gas permeation measurements (H2, N2, O2, CH4, CO2, C2H6, and C3H8), in which unique gas separation behavior was observed when compared to the pure PEI membrane...
January 31, 2017: ACS Applied Materials & Interfaces
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