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https://www.readbyqxmd.com/read/28734273/association-between-thrombophilic-genes-polymorphisms-and-recurrent-pregnancy-loss-susceptibility-in-the-iranian-population-a-systematic-review-and-meta-analysis
#1
Mahdieh Kamali, Sedigheh Hantoushzadeh, Sedigheh Borna, Hossein Neamatzadeh, Mahta Mazaheri, Mahmood Noori-Shadkam, Fatemeh Haghighi
Background: Studies have indicated that thrombophilic genes polymorphisms are associated with recurrent pregnancy loss (RPL) in the Iranian population. However, the results from these studies remained inconsistent and inconclusive. The aim of this systematic review and meta-analysis was to evaluate the precise association between thrombophilic genes polymorphisms (MTHFR C677T, MTHFR A1298C, Prothrombin G20210A, FVL G1691A, and PAI-1 4G/5G) and RPL risk in the Iranian population. Method: Electronic databases of PubMed, Web of Science, Google Scholar, and ISC were searched for eligible articles published up to April 1, 2017...
July 23, 2017: Iranian Biomedical Journal
https://www.readbyqxmd.com/read/28734193/improved-225-ac-daughter-retention-in-inpo4-containing-polymersomes
#2
R M de Kruijff, K Drost, L Thijssen, A Morgenstern, F Bruchertseifer, D Lathouwers, H T Wolterbeek, A G Denkova
Alpha-emitting radionuclides like actinium-225 ((225)Ac) are ideal candidates for the treatment of small metastasised tumours, where the long half-life of (225)Ac enables it to also reach less accessible tumours. The main challenge lies in retaining the recoiled alpha-emitting daughter nuclides, which are decoupled from targeting agents upon emission of an alpha particle and can subsequently cause unwanted toxicity to healthy tissue. Polymersomes, vesicles composed of amphiphilic block copolymers, are capable of transporting (radio)pharmaceuticals to tumours, and are ideal candidates for the retention of these daughter nuclides...
July 16, 2017: Applied Radiation and Isotopes
https://www.readbyqxmd.com/read/28732369/efficacy-and-safety-of-accelerated-partial-breast-irradiation-a-meta-analysis-of-published-randomized-studies
#3
Gengchun Liu, Zhongyi Dong, Baqun Huang, Yuelong Liu, Yan Tang, Qing Li, Yihui Zhu
BACKGROUND AND PURPOSE: Accelerated partial breast irradiation (APBI) technology has theoretical advantages in comparison with traditional adjuvant radiation therapy (whole-breast irradiation; WBI) after breast-conserving surgery. However, published randomized controlled trials have shown inconsistent outcomes. Therefore, a comprehensive assessment of the effectiveness and safety of APBI technology is needed. RESULTS: A total of 7 studies of 7452 patients were included in this analysis...
July 13, 2017: Oncotarget
https://www.readbyqxmd.com/read/28732368/meta-analysis-of-micrornas-expression-in-head-and-neck-cancer-uncovering-association-with-outcome-and-mechanisms
#4
Joshua Lubov, Mariana Maschietto, Iman Ibrahim, Alex Mlynarek, Michael Hier, Luiz Paulo Kowalski, Moulay A Alaoui-Jamali, Sabrina Daniela da Silva
Head and neck squamous cell carcinoma (HNSCC) is often diagnosed at advanced stages, incurring significant high mortality and morbidity. This review explored the risk stratification of miRNAs, and investigated the impact of miRNA networking in HNSCC prognostication. We performed a meta-analysis and a systematic literature search on online databases for papers published prior to December 1, 2016. The list of miRNAs was uploaded to MetacoreTM to construct a protein-protein interaction network, which was used to identify targets of the miRNAs and potential drugs...
July 13, 2017: Oncotarget
https://www.readbyqxmd.com/read/28732348/alcohol-consumption-and-gastric-cancer-risk-a-meta-analysis-of-prospective-cohort-studies
#5
Xue Han, Li Xiao, Yao Yu, Yu Chen, Hai-Hua Shu
We performed this meta-analysis to explore the precise quantification relationship between alcohol consumption and gastric cancer and to provide evidence for preventing gastric cancer. We searched PubMed, Embase, and Web of Science for articles published up to December 2016, and identified 23 cohort studies that included a total population of 5,886,792 subjects. We derived meta-analytic estimates using random-effects models, taking into account correlations between estimates. We also investigated the dose-response relationship between gastric cancer risk and alcohol consumption...
July 12, 2017: Oncotarget
https://www.readbyqxmd.com/read/28732257/epileptiform-discharges-in-eeg-and-seizure-risk-in-adolescent-children-of-women-with-epilepsy
#6
Joseph Samuel, Manna Jose, V S Nandini, Sanjeev V Thomas
We aimed to study the epileptiform discharges (ED) and seizure risk in EEG of 12-18-year-old children of women with epilepsy (WWE). Children of WWE who were prospectively followed up in the Kerala registry of epilepsy and pregnancy (KREP), aged 12-16years (n=92; males 48, females 44) underwent clinical evaluation and a 30-min digital 18-channel EEG. The EEG showed epileptiform discharges in 13 children (5 males and 8 females). The EDs were generalized in 9 and focal in 4 (occipital 2, frontal 1, and centroparietal 1)...
July 17, 2017: Epilepsy & Behavior: E&B
https://www.readbyqxmd.com/read/28732216/development-of-hla-b-57-01-genotyping-real-time-pcr-with-optimized-hydrolysis-probe-design
#7
Hou-Sung Jung, Gregory J Tsongalis, Joel A Lefferts
HLA-B*57:01 genotyping before abacavir (ABC) administration is a standard of care to avoid ABC-driven hypersensitivity reactions. Several HLA-B*57:01 tests have been developed, each with advantages and disadvantages. Some have limited accuracy, require special instrumentation, and/or are labor intensive and expensive. We developed a novel hydrolysis probe-based real-time PCR method of HLA-B*57:01 genotyping. Primer and probes were designed based on published sequence variations in exon 3 of HLA-B that distinguish HLA-B*57:01 from ABC-insensitive alleles such as HLA-B*57:03 and HLA-B*58:01...
July 18, 2017: Journal of Molecular Diagnostics: JMD
https://www.readbyqxmd.com/read/28732152/secukinumab-in-the-treatment-of-psoriasis-and-psoriatic-arthritis-a-review-of-the-literature
#8
M Abrouk, J Gandy, M Nakamura, K Lee, M Brodsky, R Singh, H Zhu, B Farahnik, T Bhutani, J Koo
While there are several commercially available treatment options for psoriasis and psoriatic arthritis, there remains a large number of individuals who are refractory to current modalities. In the recent past, there has been increasing evidence that interleukin (IL)-17 plays a vital role in the pathophysiology of psoriasis. Preclinical, phase II, and phase III studies of secukinumab (Cosentyx®) targeting IL-17 and its receptor have thus far proved to be promising. We reviewed the results of phase II and phase III clinical trials for secukinumab in the treatment of psoriasis and psoriatic arthritis...
July 2017: Skin Therapy Letter
https://www.readbyqxmd.com/read/28732097/resources-for-lshss-authors
#9
Shelley Gray
In this article, the Editor-in-Chief of Language, Speech, and Hearing Services in Schools (LSHSS) highlights key resources for authors wishing to publish their work in LSHSS.
July 21, 2017: Language, Speech, and Hearing Services in Schools
https://www.readbyqxmd.com/read/28731998/laparoendoscopic-rendez-vous-a-safe-alternative-to-the-treatment-of-choledocholithiasis
#10
Fernanda Kreve, Jonas Takada, Janaina Gatto, Francisco S Loss, Everson L A Artifon
The choice treatment for choledocholithiasis when associated with lithiasic cholecystitis is endoscopic retrograde cholangiopancreatography (ERCP). However, in some cases this therapeutic fails, which requires an alternative method to extract the stones. The surgical approach tends to be the next step, but it is related to greater complexity of achievement and higher complications rates. In 1993, Deslandres et al. developed the combined treatment called laparoendoscopic rendez-vous, that unites in a single stage the endoscopic treatment of choledocholithiasis and laparoscopic removal of the gallbladder...
April 2017: Revista de Gastroenterología del Perú: órgano Oficial de la Sociedad de Gastroenterología del Perú
https://www.readbyqxmd.com/read/28731945/the-changing-paradigm-of-radiotherapy-in-the-elderly-population
#11
Myer Raphael Pfeffer, Philip Blumenfeld
There is increasing awareness of the special needs for care of the elderly cancer patient. Newer precise conformal radiotherapy techniques allow the safe delivery of higher doses of radiotherapy to the target tumor while reducing the dose to surrounding critical organs. This has led to a shortening of radiotherapy protocols for both curative and palliative indications. We review these novel techniques and protocols and the published clinical studies that include elderly patients treated with these techniques...
July 2017: Cancer Journal
https://www.readbyqxmd.com/read/28731924/clinical-trial-registry-use-in-anaesthesiology-systematic-reviews-a-cross-sectional-study-of-systematic-reviews-published-in-anaesthesiology-journals-and-the-cochrane-library
#12
Blake A Umberham, Byron N Detweiler, Matthew T Sims, Matt Vassar
BACKGROUND: Publication bias within systematic reviews may result in incorrect conclusions leading to inappropriate clinical decisions and a decreased quality of patient care. Searching clinical trial registries for unpublished studies is one possible solution to minimise publication bias. OBJECTIVES: To examine rates of clinical trial registry searches in systematic reviews published in respected anaesthesiology journals and whether these searches found trials (or data) eligible for inclusion; to compare rates of registry searches between published reviews and similar reviews within the Cochrane Anaesthesia, Critical and Emergency Care Group; to conduct trial registry searches for a subset of reviews, determining whether eligible studies were overlooked; to investigate whether reporting of results in completed anaesthesia trials on ClinicalTrials...
July 20, 2017: European Journal of Anaesthesiology
https://www.readbyqxmd.com/read/28731899/current-perspectives-on-invasive-nontyphoidal-salmonella-disease
#13
Andrea H Haselbeck, Ursula Panzner, Justin Im, Stephen Baker, Christian G Meyer, Florian Marks
PURPOSE OF REVIEW: We searched PubMed for scientific literature published in the past 2 years for relevant information regarding the burden of invasive nontyphoidal Salmonella disease and host factors associated with nontyphoidal Salmonella infection and discuss current knowledge on vaccine development. The following search terms were used: Salmonella, non typhoidal/nontyphoidal, NTS, disease, bloodstream infection, invasive, sepsis/septicaemia/septicemia, bacteraemia/bacteremia, gastroenteritis, incidence, prevalence, morbidity, mortality, case fatality, host/risk factor, vaccination, and prevention/control...
July 20, 2017: Current Opinion in Infectious Diseases
https://www.readbyqxmd.com/read/28731807/distribution-of-citations-received-by-scientific-papers-published-in-the-imaging-literature-from-2001-to-2010-decreasing-inequality-and-polarization
#14
Soo Jeong Yoon, Dae Young Yoon, Hyung Jin Lee, Sora Baek, Kyoung Ja Lim, Young Lan Seo, Eun Joo Yun
OBJECTIVE: The objective of this study was to assess the distribution of citations received by scientific papers published in the imaging literature between 2001 and 2010. MATERIALS AND METHODS: We extracted the number of citations of all articles and reviews for 5 years after publication using the Scopus (Elsevier) citation database of imaging journals between 2001 and 2010. We quantitatively analyzed article and review citations from each journal and each year, including the number, proportion, and annual number of citations of the most- (≥ 20 citations) and least-cited (three or fewer citations) papers; ratio of most-cited to least-cited papers; 75/25 percentile citation ratio; 90/10 percentile citation ratio; Gini coefficient; and Kolkata index...
August 2017: AJR. American Journal of Roentgenology
https://www.readbyqxmd.com/read/28731782/identifiability-of-components-of-complex-interventions-using-factorial-designs
#15
Andreas Gleiss
OBJECTIVE: The aim of this contribution is to demonstrate how the component structure of a complex intervention (CI) can be efficiently exploited for study design and statistical analysis by using concepts of factorial designs. Many studies on CIs in complementary and alternative medicine exhibit the structure of factorial designs, where all possible combinations of the levels of two or more treatments occur together. In this contribution, the treatment arms of CI studies are explicitly viewed as factorial combinations of their components...
July 21, 2017: Journal of Alternative and Complementary Medicine: Research on Paradigm, Practice, and Policy
https://www.readbyqxmd.com/read/28731772/publisher-s-note-infrared-topological-plasmons-in-graphene-phys-rev-lett-118-245301-2017
#16
Dafei Jin, Thomas Christensen, Marin Soljac Ić, Nicholas X Fang, Ling Lu, Xiang Zhang
This corrects the article DOI: 10.1103/PhysRevLett.118.245301.
July 7, 2017: Physical Review Letters
https://www.readbyqxmd.com/read/28731661/-melkersson-rosenthal-syndrome-report-of-two-pediatric-cases
#17
Lucas Bordino, Mariana L Juchli, Marcelo Fernández, María de Los Ángeles Fitz Maurice, Andrea Martins, Zaida E Ramírez, Roxana Spini
Melkersson Rosenthal syndrome is a very infrequent disease of unknown etiology, chronic and progressive course, with neurocutaneous disease that affects the orofacial innervation and mucocutaneous tissues with non-caseating granulomatous infiltration. Clinically, it is characterized by the diagnostic triad: recurrent edema of lips and/or face; recurrent and alternating acute peripheral facial paralysis and scrotal or geographic tongue. The condition generally presents as oligosymptomatic or monosymptomatic form...
August 1, 2017: Archivos Argentinos de Pediatría
https://www.readbyqxmd.com/read/28731657/publication-of-abstracts-presented-at-the-national-pediatric-research-meetings-of-the-argentine-society-of-pediatrics-related-factors
#18
Paula Domínguez, María F Ossorio, Eduardo Cuestas, Norberto Giglio, Carlos Grandi, Facundo García-Bournissen, Santiago Vidaurreta, Jaime Altcheh, Fernando Ferrero
OBJETIVES: To estimate the proportion of abstracts presented at National Pediatric Research Meetings that are fully-published and describe their design and factors that influence nonpublication. METHODS: Descriptive and analytical study including all abstracts presented at National Pediatric Research Meetings (1998-2011). One author per study was identified and asked to complete a survey on its design, publication and factors associated with non-publication. RESULTS: Out of 746 abstracts that were submitted, the authors of 522 (70%) completed the survey...
August 1, 2017: Archivos Argentinos de Pediatría
https://www.readbyqxmd.com/read/28731522/wildlife-species-benefitting-from-a-greener-arctic-are-most-sensitive-to-shrub-cover-at-leading-range-edges
#19
Helen C Wheeler, Toke T Høye, Jens-Christian Svenning
Widespread expansion of shrubs is occurring across the Arctic. Shrub expansion will substantially alter arctic wildlife habitats. Identifying which wildlife species are most affected by shrubification is central to predicting future arctic community composition. Through meta-analysis, we synthesized the published evidence for effects of canopy-forming shrubs on birds and mammals in the Arctic and Subarctic. We examined variation in species behaviour, distribution and population dynamics in birds and mammals in response to shrub cover (including shrub cover indicators such as shrub occurrence, extent, density and height)...
July 21, 2017: Global Change Biology
https://www.readbyqxmd.com/read/28731467/uncultivated-microbes-in-need-of-their-own-taxonomy
#20
Konstantinos T Konstantinidis, Ramon Rosselló-Móra, Rudolf Amann
The great majority of microbial species remains uncultured, severely limiting their taxonomic characterization and thus communication among scientists. Although Candidatus was devised as a provisional category to classify uncultured taxa, it has not been widely accepted owing to technical limitations and lack of priority of Candidatus names in the official nomenclature. High-throughput sequencing provides the potential for data-rich taxonomic descriptions of uncultivated microbes, comparable in quality to those of cultured organisms...
July 21, 2017: ISME Journal
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