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https://www.readbyqxmd.com/read/27936510/systematic-evaluation-of-cs-rosetta-for-membrane-protein-structure-prediction-with-sparse-noe-restraints
#1
Katrin Reichel, Olivier Fisette, Tatjana Braun, Olivier F Lange, Gerhard Hummer, Lars V Schäfer
We critically test and validate the CS-Rosetta methodology for de novo structure prediction of α-helical membrane proteins (MPs) from NMR data, such as chemical shifts and NOE distance restraints. By systematically reducing the number and type of NOE restraints, we focus on determining the regime in which MP structures can be reliably predicted and pinpoint the boundaries of the approach. Five MPs of known structure were used as test systems, phototaxis sensory rhodopsin II (pSRII), a subdomain of pSRII, disul_de binding protein B (DsbB), microsomal prostaglandin E2 synthase-1 (mPGES-1), and translocator protein (TSPO)...
December 9, 2016: Proteins
https://www.readbyqxmd.com/read/27936499/the-anatomy-of-mammalian-sweet-taste-receptors
#2
Jean-Baptiste Chéron, Jérôme Golebiowski, Serge Antonczak, Sébastien Fiorucci
All sweet-tasting compounds are detected by a single G-protein coupled receptor (GPCR), the heterodimer T1R2-T1R3, for which no experimental structure is available. The sweet taste receptor is a class C GPCR, and the recently published crystallographic structures of metabotropic glutamate receptor (mGluR) 1 and 5 provide a significant step forward for understanding structure-function relationships within this family. In this article, we recapitulate more than six hundred single point site-directed mutations and available structural data to obtain a critical alignment of the sweet taste receptor sequences with respect to other class C GPCRs...
December 9, 2016: Proteins
https://www.readbyqxmd.com/read/27936447/single-incision-laparoscopic-excision-of-a-chylous-mesenteric-cyst-a-case-report
#3
Masanori Yoshimitsu, Manabu Emi, Masashi Miguchi, Hiroshi Ota, Keishi Hakoda, Ichiro Omori, Toshihiko Kohashi, Naoki Hirabayashi, Hideki Ohdan
INTRODUCTION: Chylous mesenteric cysts are rare intra-abdominal lesions located in the mesentery of the gastrointestinal tract and may extend from the base of the mesentery into the retroperitoneum. The treatment is the complete removal of the cyst PRESENTATION OF CASE: A 49-year-old female presented with abdominal pain. Abdominal computed tomography showed a 5.0-cm-diameter intraabdominal, homogenous cystic lesion located on the mesentery of the small intestine. Single-incision laparoscopic surgery was performed for complete resection...
November 22, 2016: International Journal of Surgery Case Reports
https://www.readbyqxmd.com/read/27936437/clinical-trial-methodology-to-assess-the-efficacy-effectiveness-of-long-acting-antipsychotics-randomized-controlled-trials-vs-naturalistic-studies
#4
REVIEW
Andrea Fagiolini, Paola Rocca, Serafino De Giorgi, Edoardo Spina, Giovanni Amodeo, Mario Amore
Schizophrenia presents unique difficulties in clinical trial design associated with the condition's variable presentation and clinical course, and multiple features influencing affect, cognition, volition and perception. Randomized controlled trials (RCTs) are explanatory studies using a carefully selected patient population, predefined assessment intervals and, generally, symptom-focused endpoints. Naturalistic studies are pragmatic, with no active intervention, and outcomes that are generally those used in clinical practice (e...
November 28, 2016: Psychiatry Research
https://www.readbyqxmd.com/read/27936421/catheter-directed-endovascular-application-of-thrombin-report-of-3-cases-and-review-of-the-literature
#5
Majid Maybody, David C Madoff, Raymond H Thornton, Steven A Morales, Chaya S Moskowitz, Meier Hsu, Lynn A Brody, Karen T Brown, Anne M Covey
PURPOSE: To report 3 new cases of catheter-directed endovascular application of thrombin and explore trends by analysis of published case series. MATERIALS AND METHODS: Institutional Review Board approved this retrospective study. All cases of non-tumoral arterial embolization performed from January 2003 to January 2015 at our institution were retrospectively reviewed. Thrombin was used in 7 of 589 cases. In 3 cases intra arterial thrombin was injected via catheter to treat active hemorrhage...
November 29, 2016: Clinical Imaging
https://www.readbyqxmd.com/read/27936411/a-network-analysis-of-dsm-5-posttraumatic-stress-disorder-symptoms-and-correlates-in-u-s-military-veterans
#6
Cherie Armour, Eiko I Fried, Marie K Deserno, Jack Tsai, Robert H Pietrzak
OBJECTIVE: Recent developments in psychometrics enable the application of network models to analyze psychological disorders, such as PTSD. Instead of understanding symptoms as indicators of an underlying common cause, this approach suggests symptoms co-occur in syndromes due to causal interactions. The current study has two goals: (1) examine the network structure among the 20 DSM-5 PTSD symptoms, and (2) incorporate clinically relevant variables to the network to investigate whether PTSD symptoms exhibit differential relationships with suicidal ideation, depression, anxiety, physical functioning/quality of life (QoL), mental functioning/QoL, age, and sex...
November 27, 2016: Journal of Anxiety Disorders
https://www.readbyqxmd.com/read/27936385/interrater-reliability-in-pediatric-urodynamic-tracings-a-pilot-study
#7
Anne G Dudley, Daniel P Casella, Chelsea J Lauderdale, Shilin Zhao, Heidi Chen, Stacy T Tanaka, John C Thomas, John C Pope, Mark C Adams, John W Brock, Chevis N Shannon, Douglass B Clayton
PURPOSE: Urodynamic studies are crucial to neuropathic bladder management and they often determine surgical intervention. However, current evidence indicates that interpretations show poor agreement across physicians. We sought to determine the interrater reliability of urodynamic interpretation in our practice. We hypothesized that there would be strong correlation among pediatric urologists of similar training in a single academic practice. MATERIALS AND METHODS: We retrospectively identified patients with neuropathic bladder who underwent urodynamics at our institution between 2014 and 2015...
December 6, 2016: Journal of Urology
https://www.readbyqxmd.com/read/27936322/control-of-activation-mode-to-achieve-diastereodivergence-in-asymmetric-syntheses-of-chiral-spiropiperidinone-derivatives
#8
Xiang Li, Wei Huang, Yan-Qing Liu, Jing-Wen Kang, Dan Xia, Gu He, Cheng Peng, Bo Han
An efficient organocatalytic cascade reaction has been developed involving a Michael-hemiaminalization relay for the asymmetric synthesis of spiropiperidinone derivatives bearing adjacent quaternary and tertiary chiral centers via LUMO or HOMO activation. Importantly, this methodology demonstrates that applying distinct activation modes to different substrates in the same reaction can diverge diastereoselectivity. To our knowledge, this is also one of the few published cases of primary amine-catalytic [3+3] cycloaddition reactions involving α-branched β-ketoamides...
December 9, 2016: Journal of Organic Chemistry
https://www.readbyqxmd.com/read/27936259/-reconstructing-a-scholarly-network-from-the-bonneval-hospital-collections-relationships-and-misconceptions-derived-from-historical-archives
#9
Emmanuel Delille
The French psychiatric hospital Henri Ey in Bonneval (Eure-et-Loir, Central France) is known in the history of psychiatry for a series of conferences, which brought together several key figures in the mental health field in the 1940s. The conference sessions have been published in two major volumes: Le Problème de la psychogenèse des névroses et des psychoses (The Problem of the Psychogenesis of Neuroses and Psychoses, 1950), and L'Inconscient (The Unconscious, 1966). The proceedings consist of theoretical essays and minutes of the intellectual discussions between French psychiatrists, neurologists, psychologists, psychoanalysts and philosophers...
2016: Santé Mentale Au Québec
https://www.readbyqxmd.com/read/27936117/no-modulation-of-visual-cortex-excitability-by-transcranial-direct-current-stimulation
#10
Sabrina Brückner, Thomas Kammer
Measuring phosphene thresholds (PTs) is often used to investigate changes in the excitability of the human visual cortex through different brain stimulation methods like repetitive transcranial magnetic stimulation (rTMS) or transcranial direct current stimulation (tDCS). In several studies, PT increase or decrease has been shown after rTMS or tDCS application. Recently, using PT measurements we showed that the state of the neurons in the visual cortex after rTMS might have an influence on the modulatory effects of stimulation...
2016: PloS One
https://www.readbyqxmd.com/read/27936069/multimodal-imaging-of-photoreceptor-structure-in-choroideremia
#11
Lynn W Sun, Ryan D Johnson, Vesper Williams, Phyllis Summerfelt, Alfredo Dubra, David V Weinberg, Kimberly E Stepien, Gerald A Fishman, Joseph Carroll
PURPOSE: Choroideremia is a progressive X-linked recessive dystrophy, characterized by degeneration of the retinal pigment epithelium (RPE), choroid, choriocapillaris, and photoreceptors. We examined photoreceptor structure in a series of subjects with choroideremia with particular attention to areas bordering atrophic lesions. METHODS: Twelve males with clinically-diagnosed choroideremia and confirmed hemizygous mutations in the CHM gene were examined. High-resolution images of the retina were obtained using spectral domain optical coherence tomography (SD-OCT) and both confocal and non-confocal split-detector adaptive optics scanning light ophthalmoscope (AOSLO) techniques...
2016: PloS One
https://www.readbyqxmd.com/read/27936006/prognostic-value-of-red-blood-cell-distribution-width-in-non-cardiovascular-critically-or-acutely-patients-a-systematic-review
#12
Rubin Luo, Jian Hu, Libing Jiang, Mao Zhang
BACKGROUND: RDW (red cell distribution width) has been reported to been associated with the prognosis of patients with cardiovascular diseases. However, RDW is often overlooked by clinicians in treating patients with non-cardiovascular diseases, especially in an emergency. The objective of this systematic review is to explore the prognostic value of RDW in non-cardiovascular emergencies. METHODS: PubMed, EMBASE, and the Cochrane Central Register of Controlled Trials were systematically searched from their inception to December 31, 2015...
2016: PloS One
https://www.readbyqxmd.com/read/27935855/estimation-of-fetal-weight-by-ultrasonography-after-preterm-premature-rupture-of-membranes-comparison-of-different-formulas
#13
Sertac Esin, Mutlu Hayran, Yusuf Aytac Tohma, Mahmut Guden, Ismail Alay, Deniz Esinler, Serdar Yalvac, Omer Kandemir
OBJECTIVE: To compare different ultrasonographic fetal weight estimation formulas in predicting the fetal birth weight of preterm premature rupture of membrane (PPROM) fetuses. METHODS: Based on the ultrasonographic measurements, the estimated fetal weight (EFW) was calculated according to the published formulas. The comparisons used estimated birth weight (EBW) and observed birth weight (OBW) to calculate the mean absolute percentage error [(EBW-OBW)/OBW×100], mean percentage error [(EBW-OBW)/OBW×100)] and their 95% confidence intervals...
December 9, 2016: Journal of Perinatal Medicine
https://www.readbyqxmd.com/read/27935775/anesthesia-information-management-systems
#14
Thomas Corey Davis
Anesthesia information management systems (AIMS) are rapidly gaining widespread acceptance. Aggressively promoted as an improvement to manual-entry recordkeeping systems in the areas of accuracy, completeness, quality improvement, billing, and vigilance, these systems record all patient vital signs and parameters, providing a legible hard copy and permanent electronic record. With well-documented financial incentives, as well as government subsidies, AIMS are becoming adopted at an unprecedented rate. With the goals of the federal government to enhance the use of the electronic medical record, there is an emerging belief that AIMS may soon be mandated, with more limited choices than currently available...
January 2017: Annual Review of Nursing Research
https://www.readbyqxmd.com/read/27935626/assessment-of-radial-torsion-using-computed-tomography-in-dogs-with-and-without-antebrachial-limb-deformity
#15
Kevin Kroner, Katie Cooley, Seamus Hoey, Scott J Hetzel, Jason A Bleedorn
OBJECTIVE: To evaluate the reliability of radial torsion assessment in dogs using computed tomography (CT). STUDY DESIGN: Cadaveric and retrospective observational clinical study. ANIMALS: Thoracic limbs (n = 40) from bilateral normal cadaveric canine specimens (10 pairs) and unilateral antebrachial angular limb deformity (ALD) dogs (10 uniapical and 10 biapical deformities). METHODS: Limbs were evaluated using CT...
December 9, 2016: Veterinary Surgery: VS
https://www.readbyqxmd.com/read/27935448/diagnostic-accuracy-of-motor-evoked-potentials-to-detect-neurological-deficit-during-idiopathic-scoliosis-correction-a-systematic-review
#16
Parthasarathy D Thirumala, Donald J Crammond, Yoon K Loke, Hannah L Cheng, Jessie Huang, Jeffrey R Balzer
OBJECTIVE The goal of this study was to evaluate the efficacy of intraoperative transcranial motor evoked potential (TcMEP) monitoring in predicting an impending neurological deficit during corrective spinal surgery for patients with idiopathic scoliosis (IS). METHODS The authors searched the PubMed and Web of Science database for relevant lists of retrieved reports and/or experiments published from January 1950 through October 2014 for studies on TcMEP monitoring use during IS surgery. The primary analysis of this review fit the operating characteristic into a hierarchical summary receiver operating characteristic curve model to determine the efficacy of intraoperative TcMEP-predicted change...
December 9, 2016: Journal of Neurosurgery. Spine
https://www.readbyqxmd.com/read/27935411/climacteric-ripening-of-apple-fruit-is-regulated-by-transcriptional-circuits-stimulated-by-cross-talks-between-ethylene-and-auxin
#17
Nicola Busatto, Alice Tadiello, Livio Trainotti, Fabrizio Costa
Apple is a fleshy fruit distinguished by a climacteric type of ripening, since most of the relevant physiological changes are triggered and governed by the action of ethylene. After its production, this hormone is perceived by a series of receptors to regulate, through a signaling cascade, downstream ethylene related genes. The possibility to control the effect of ethylene opened new horizons to the improvement of the postharvest fruit quality. To this end, 1-methylcyclopropene (1-MCP), an ethylene antagonist, is routinely used to modulate the ripening progression increasing storage life...
December 9, 2016: Plant Signaling & Behavior
https://www.readbyqxmd.com/read/27935308/combining-molecular-scaffolds-from-fda-approved-drugs-application-to-drug-discovery
#18
Richard David Taylor, Malcolm MacCoss, Alastair D G Lawson
We have enumerated all linear combinations of ring systems from FDA approved drugs, up to three rings in length and up to four bonds linkers to give an in-silico database of approximately 14 million molecules. This virtual library was compared with molecular databases of published and commercially available compounds to assess the prevalence of drug ring combinations in modern medicinal chemistry and to identify areas of under-represented, but clinically validated, chemical space. From the 10 trillion molecular comparisons, we found that less than 1% of the possible combinations of drug ring systems appear in commercially available libraries...
December 9, 2016: Journal of Medicinal Chemistry
https://www.readbyqxmd.com/read/27935285/mechanical-testing-of-engineered-spider-silk-filaments-provides-insights-into-molecular-features-on-a-meso-scale
#19
Gregor Lang, Benedikt Richard Neugirg, Daniel Kluge, Andreas Fery, Thomas Scheibel
Spider dragline silk shows the highest toughness in comparison to all other known natural or man-made fibers. Despite a broad experimental foundation concerning the macroscopic silk thread properties as well as a thorough simulation-based molecular understanding, the impact of the mesoscale building blocks, namely nano-/submicron-sized filaments, on the mechanical properties of the threads remains the missing link. Here, we illustrate the function of these meso-scaled building blocks using electrospun fibers made of a recombinant spider silk protein and show the impact of β-sheet content and fiber hydration on their mechanical performance...
December 9, 2016: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/27935220/nuclear-co-repressor-ncor-is-required-to-maintain-insulin-sensitivity-in-c2-c12-myotubes
#20
Abhijeet K Choudhary, Chinmoy S Dey
Nuclear co-repressor (NCoR) regulate peripheral insulin sensitivity, however its role in modulating insulin sensitivity in skeletal muscle remains elusive. Present study investigated protein expression and effect of NCoR on insulin sensitivity in murine skeletal muscle cell line C2 C12 . Myotubes as compared to myoblasts of C2 C12 cells was found to be more sensitive in response to insulin as increase in insulin stimulated phosphorylation of AKT at serine 473 residue (pAKT(S473) ) was significantly higher in myotubes...
December 9, 2016: Cell Biology International
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