Yan-Ru Zhang, Zhen Yu, Wen-Jie Xiong, Xu-Xiang Liu, Hui-Min Liu, Rui Cui, Qi Wang, Wen-Ming Chen, Lu-Gui Qiu, Shu-Hua Yi
BACKGROUND: TOSO, also named Fas inhibitory molecule 3 (FAIM3), has recently been identified as an immunoglobulin M (IgM) Fc receptor (FcμR). Previous studies have shown that TOSO is specifically over-expressed in chronic lymphocytic leukemia (CLL). However, the functions of TOSO in CLL remain unknown. The B-cell receptor (BCR) signaling pathway has been reported to be constitutively activated in CLL. Here, we aimed to investigate the functions of TOSO in the BCR signaling pathway and the pathogenesis of CLL...
August 10, 2020: Chinese Medical Journal