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https://www.readbyqxmd.com/read/28224875/-thiamine-in-patients-with-alcohol-use-disorder-and-wernicke-s-encephalopathy
#1
D J Brinkman, J K Bekema, M A Kuijenhoven, J W Wijnia, M J H J Dekker, M A van Agtmael
- Patients with alcohol use disorder frequently have a thiamine deficiency.- A potential life-threatening complication of thiamine deficiency is Wernicke's encephalopathy.- Since it is clinically difficult to recognize Wernicke's encephalopathy, this condition is often treated inadequately. - Early supplementation of thiamine is important to avoid irreversible neurological damage. - There are differences between the Dutch guidelines regarding the supplementation of thiamine for the treatment of alcoholic use disorder, and those for Wernicke's encephalopathy...
2017: Nederlands Tijdschrift Voor Geneeskunde
https://www.readbyqxmd.com/read/28212284/micronutrient-intakes-in-553-dutch-elite-and-sub-elite-athletes-prevalence-of-low-and-high-intakes-in-users-and-non-users-of-nutritional-supplements
#2
Floris Wardenaar, Naomi Brinkmans, Ingrid Ceelen, Bo Van Rooij, Marco Mensink, Renger Witkamp, Jeanne De Vries
This study investigated whether athletes meet micronutrient recommendations and whether the adequacy of their intake is related to the use of dietary supplements, sport nutrition products or a combination. Micronutrient intakes of 553 Dutch (sub-) elite athletes were assessed using web-based 24-h dietary recalls with accompanying nutritional supplement questionnaires. In the majority of both users and non-users of dietary supplements, vitamin D intake was below the estimated average requirement (AR) if supplements were not included in the analysis...
February 15, 2017: Nutrients
https://www.readbyqxmd.com/read/28208581/macronutrient-intakes-in-553-dutch-elite-and-sub-elite-endurance-team-and-strength-athletes-does-intake-differ-between-sport-disciplines
#3
Floris Wardenaar, Naomi Brinkmans, Ingrid Ceelen, Bo Van Rooij, Marco Mensink, Renger Witkamp, Jeanne De Vries
Web-based 24-h dietary recalls and questionnaires were obtained from 553 Dutch well-trained athletes. The total energy and macronutrient intake was compared between discipline-categories (endurance, team, and strength) within gender, and dietary inadequacy, i.e., too low or high intakes, according to selected recommendations and guidelines, was evaluated by applying a probability approach. On average, 2.83 days per person were reported with a mean energy intake of 2566-2985 kcal and 1997-2457 kcal per day, for men and women, respectively...
February 10, 2017: Nutrients
https://www.readbyqxmd.com/read/28207320/cardiac-findings-in-quarter-horses-with-heritable-equine-regional-dermal-asthenia
#4
Erin L Brinkman, Benjamin C Weed, Sourav S Patnaik, Bryn L Brazile, Ryan M Centini, Robert W Wills, Bari Olivier, Dodd G Sledge, Jim Cooley, Jun Liao, Ann M Rashmir-Raven
OBJECTIVE To compare biomechanical and histologic features of heart valves and echocardiographic findings between Quarter Horses with and without heritable equine regional dermal asthenia (HERDA). DESIGN Prospective case-control study. ANIMALS 41 Quarter Horses. PROCEDURES Ultimate tensile strength (UTS) of aortic and mitral valve leaflets was assessed by biomechanical testing in 5 horses with HERDA and 5 horses without HERDA (controls). Histologic evaluation of aortic and mitral valves was performed for 6 HERDA-affected and 3 control horses...
March 1, 2017: Journal of the American Veterinary Medical Association
https://www.readbyqxmd.com/read/28188471/visualization-of-vascular-injuries-in-extremity-trauma
#5
Kwitae Chong, Chenfanfu Jiang, Daniel Ram, Anand Santhanam, Demetri Terzopoulos, Peyman Benharash, Erik Dutson, Joseph Teran, Jeff D Eldredge
A tandem of particle-based computational methods is adapted to simulate injury and hemorrhage in the human body. In order to ensure anatomical fidelity, a three-dimensional model of a targeted portion of the human body is reconstructed from a dense sequence of CT scans of an anonymized patient. Skin, bone and muscular tissue are distinguished in the imaging data and assigned with their respective material properties. An injury geometry is then generated by simulating the mechanics of a ballistic projectile passing through the anatomical model with the material point method...
February 11, 2017: Medical & Biological Engineering & Computing
https://www.readbyqxmd.com/read/28181431/enhanced-oxygen-reduction-activity-on-r-p-phase-decorated-la0-8sr0-2feo3-%C3%AE-3d-heterostructured-cathode-for-solid-oxide-fuel-cells
#6
Tao Hong, Mingyang Zhao, Kyle Brinkman, Fanglin Chen, Chang-Rong Xia
A new heterostructured (La,Sr)2FeO4-δ (LSF214)-La0.8Sr0.2FeO3-δ (LSF113) electrode has been synthesized to improve the oxygen reduction reaction (ORR). This new materials system was fabricated by the deposition of Sr(NO3)2 into the LSF113 framework followed by subsequent heat treatment resulting in a new three-dimensional (3D) LSF214-LSF113 heterostructured electrode. This material system consists of a with Ruddlesden-Popper (R-P) LSF214 phase formed on the surface of the LSF113 framework. The ORR activity has been enhanced by one order of magnitude using the LSF214-LSF113 heterostructured electrode...
February 9, 2017: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/28166785/a-comparison-of-three-treatment-strategies-in-recent-onset-non-systemic-juvenile-idiopathic-arthritis-initial-3-months-results-of-the-best-for-kids-study
#7
P C E Hissink Muller, D M C Brinkman, D Schonenberg, Y Koopman-Keemink, I C J Brederije, W P Bekkering, T W Kuijpers, M A J van Rossum, L W A van Suijlekom-Smit, J M van den Berg, C F Allaart, R Ten Cate
BACKGROUND: Combination therapy with prednisone or etanercept may induce earlier and/or more improvement in disease activity in Disease Modifying Anti Rheumatic Drug (DMARD) naïve non-systemic Juvenile Idiopathic Arthritis (JIA) patients. Here we present three months clinical outcome of initial treatments of the BeSt-for-Kids study. METHODS: Included patients were randomized to either: 1. initial DMARD-monotherapy (sulfasalazine (SSZ) or methotrexate (MTX)), 2...
February 6, 2017: Pediatric Rheumatology Online Journal
https://www.readbyqxmd.com/read/28160404/evaluating-flow-cytometer-performance-with-weighted-quadratic-least-squares-analysis-of-led-and-multi-level-bead-data
#8
David R Parks, Faysal El Khettabi, Eric Chase, Robert A Hoffman, Stephen P Perfetto, Josef Spidlen, James C S Wood, Wayne A Moore, Ryan R Brinkman
We developed a fully automated procedure for analyzing data from LED pulses and multilevel bead sets to evaluate backgrounds and photoelectron scales of cytometer fluorescence channels. The method improves on previous formulations by fitting a full quadratic model with appropriate weighting and by providing standard errors and peak residuals as well as the fitted parameters themselves. Here we describe the details of the methods and procedures involved and present a set of illustrations and test cases that demonstrate the consistency and reliability of the results...
February 3, 2017: Cytometry. Part A: the Journal of the International Society for Analytical Cytology
https://www.readbyqxmd.com/read/28151796/clinical-and-prognostic-features-of-patients-with-esophageal-cancer-and-multiple-primary-cancers-a-retrospective-single-institution-study
#9
Yoshifumi Baba, Naoya Yoshida, Koichi Kinoshita, Masaaki Iwatsuki, Yo-Ichi Yamashita, Akira Chikamoto, Masayuki Watanabe, Hideo Baba
OBJECTIVE: To investigate the clinical and prognostic characteristics of patients with esophageal cancer and multiple primary cancers. SUMMARY BACKGROUND DATA: Patients with esophageal cancer frequently have multiple primary cancers, the presence of which may complicate physicians' decision-making because the clinical and prognostic features of such patients remain unknown. METHODS: This retrospective single-institution study included 538 consecutive patients who had undergone resection of esophageal cancer...
February 1, 2017: Annals of Surgery
https://www.readbyqxmd.com/read/28146435/loss-of-mtss1-results-in-increased-metastatic-potential-in-pancreatic-cancer
#10
Ann E Zeleniak, Wei Huang, Mary K Brinkman, Melissa L Fishel, Reginald Hill
Pancreatic ductal adenocarcinoma (PDAC) has a 5-year survival rate of 7%. This dismal prognosis is largely due to the inability to diagnose the disease before metastasis occurs. Tumor cell dissemination occurs early in PDAC. While it is known that inflammation facilitates this process, the underlying mechanisms responsible for this progression have not been fully characterized. Here, we functionally test the role of metastasis suppressor 1 (MTSS1) in PDAC. Despite evidence showing that MTSS1 could be important for regulating metastasis in many different cancers, its function in PDAC has not been studied...
January 27, 2017: Oncotarget
https://www.readbyqxmd.com/read/28112740/a-somatic-mutational-process-recurrently-duplicates-germline-susceptibility-loci-and-tissue-specific-super-enhancers-in-breast-cancers
#11
Dominik Glodzik, Sandro Morganella, Helen Davies, Peter T Simpson, Yilong Li, Xueqing Zou, Javier Diez-Perez, Johan Staaf, Ludmil B Alexandrov, Marcel Smid, Arie B Brinkman, Inga Hansine Rye, Hege Russnes, Keiran Raine, Colin A Purdie, Sunil R Lakhani, Alastair M Thompson, Ewan Birney, Hendrik G Stunnenberg, Marc J van de Vijver, John W M Martens, Anne-Lise Børresen-Dale, Andrea L Richardson, Gu Kong, Alain Viari, Douglas Easton, Gerard Evan, Peter J Campbell, Michael R Stratton, Serena Nik-Zainal
Somatic rearrangements contribute to the mutagenized landscape of cancer genomes. Here, we systematically interrogated rearrangements in 560 breast cancers by using a piecewise constant fitting approach. We identified 33 hotspots of large (>100 kb) tandem duplications, a mutational signature associated with homologous-recombination-repair deficiency. Notably, these tandem-duplication hotspots were enriched in breast cancer germline susceptibility loci (odds ratio (OR) = 4.28) and breast-specific 'super-enhancer' regulatory elements (OR = 3...
January 23, 2017: Nature Genetics
https://www.readbyqxmd.com/read/28109381/endovascular-technique-for-repair-of-descending-thoracic-aortic-aneurysm-after-coarctation-operation
#12
Heike Baumgarten, John J Squiers, William T Brinkman, Javier Vasquez
The incidence of aneurysm after open surgical repair of coarctation is 11% to 24%. If the condition is left untreated, fatal rupture may occur. Thoracic endovascular aortic repair (TEVAR) has been reported as a feasible and safe alternative to open surgical repeated procedures in this context. However, TEVAR might be challenging because of the proximity of the pathologic condition to the supraaortic vessels and the ongoing presence of the coarctation. We report a unique case of a 48-year old man undergoing TEVAR because of aortic aneurysm after previous surgical coarctation treatment and successful closure of the coarctation with a vascular plug device...
February 2017: Annals of Thoracic Surgery
https://www.readbyqxmd.com/read/28105974/baseline-practices-for-the-application-of-genomic-data-supporting-regulatory-food-safety
#13
Dominic Lambert, Arthur Pightling, Emma Griffiths, Gary Van Domselaar, Peter Evans, Sharon Berthelet, Duncan Craig, P Scott Chandry, Robert Stones, Fiona Brinkman, Alexandre Angers-Loustau, Joachim Kreysa, Weida Tong, Burton Blais
The application of new data streams generated from next-generation sequencing (NGS) has been demonstrated for food microbiology, pathogen identification, and illness outbreak detection. The establishment of best practices for data integrity, reproducibility, and traceability will ensure reliable, auditable, and transparent processes underlying food microbiology risk management decisions. We outline general principles to guide the use of NGS data in support of microbiological food safety. Regulatory authorities across intra- and international jurisdictions can leverage this effort to promote the reliability, consistency, and transparency of processes used in the derivation of genomic information for regulatory food safety purposes, and to facilitate interactions and the transfer of information in the interest of public health...
January 19, 2017: Journal of AOAC International
https://www.readbyqxmd.com/read/28098955/the-impact-of-childhood-cancer-perceptions-of-adult-survivors
#14
Victoria W Willard, James L Klosky, Chenghong Li, Deo Kumar Srivastava, Tara M Brinkman, Leslie L Robison, Melissa M Hudson, Sean Phipps
BACKGROUND: The objective of this study was to describe perceptions and associated risk factors of the impact of cancer on functional outcomes, including social relationships, exercise, finances, and religion, among adult survivors of childhood cancer. METHODS: Evaluable participants included 3001 adult survivors (mean age, 32.5 years; range, 18.3-63.8 years; 24.1 years from diagnosis; 50.8% male; 84.9% Caucasian) who were enrolled in the St. Jude Lifetime Cohort study...
January 18, 2017: Cancer
https://www.readbyqxmd.com/read/28073096/high-density-scalp-eeg-in-frontal-lobe-epilepsy
#15
Anteneh M Feyissa, Jeffrey W Britton, Jamie Van Gompel, Terrance L Lagerlund, Elson So, Lilly C Wong-Kisiel, Gregory C Cascino, Benjamin H Brinkman, Cindy L Nelson, Robert Watson, Gregory A Worrell
PURPOSE: Localization of seizures in frontal lobe epilepsy using the 10-20 system scalp EEG is often challenging because neocortical seizure can spread rapidly, significant muscle artifact, and the suboptimal spatial resolution for seizure generators involving mesial frontal lobe cortex. Our aim in this study was to determine the value of visual interpretation of 76 channel high density EEG (hdEEG) monitoring (10-10 system) in patients with suspected frontal lobe epilepsy, and to evaluate concordance with MRI, subtraction ictal SPECT co-registered to MRI (SISCOM), conventional EEG, and intracranial EEG (iEEG)...
January 2, 2017: Epilepsy Research
https://www.readbyqxmd.com/read/28070769/emotional-distress-impacts-quality-of-life-evaluation-a-report-from-the-childhood-cancer-survivor-study
#16
I-Chan Huang, Tara M Brinkman, Gregory T Armstrong, Wendy Leisenring, Leslie L Robison, Kevin R Krull
PURPOSE: We compared health-related quality of life (HRQOL) between adult survivors of childhood cancer and siblings by investigating the mediating role of emotional distress on HRQOL assessment, and examining the extent to which emotional distress affected the item responses of HRQOL measures given the same underlying HRQOL (i.e., measurement non-invariance). METHODS: Cancer survivors (7103) and siblings (390) enrolled in Childhood Cancer Survivor Study who completed the SF-36 measuring HRQOL and the Brief Symptom Inventory-18 measuring anxiety, depression, and somatization were analyzed...
January 9, 2017: Journal of Cancer Survivorship: Research and Practice
https://www.readbyqxmd.com/read/28035022/approach-for-classification-and-severity-grading-of-long-term-and-late-onset-health-events-among-childhood-cancer-survivors-in-the-st-jude-lifetime-cohort
#17
Melissa M Hudson, Matthew J Ehrhardt, Nickhill Bhakta, Malek Baassiri, Hesham Eissa, Wassim Chemaitilly, Daniel M Green, Daniel A Mulrooney, Gregory T Armstrong, Tara M Brinkman, James L Klosky, Kevin R Krull, Noah D Sabin, Carmen L Wilson, I-Chan Huang, Johnnie K Bass, Karen Hale, Sue Kaste, Raja B Khan, Deo Kumar Srivastava, Yutaka Yasui, Vijaya M Joshi, Saumini Srinivasan, Dennis Stokes, Mary Ellen Hoehn, Matthew Wilson, Kirsten K Ness, Leslie L Robison
Characterization of toxicity associated with cancer and its treatment is essential to quantify risk, inform optimization of therapeutic approaches for newly diagnosed patients, and guide health surveillance recommendations for long-term survivors. The National Cancer Institute's Common Terminology Criteria for Adverse Events (CTCAE) provides a common rubric for grading severity of adverse outcomes in cancer patients that is widely used in clinical trials. The CTCAE has also been used to assess late cancer treatment-related morbidity, but is not fully representative of the spectrum of events experienced by pediatric and aging adult survivors of childhood cancer...
December 29, 2016: Cancer Epidemiology, Biomarkers & Prevention
https://www.readbyqxmd.com/read/27992529/exposure-of-bacterial-biofilms-to-electrical-current-leads-to-cell-death-mediated-in-part-by-reactive-oxygen-species
#18
Cassandra L Brinkman, Suzannah M Schmidt-Malan, Melissa J Karau, Kerryl Greenwood-Quaintance, Daniel J Hassett, Jayawant N Mandrekar, Robin Patel
Bacterial biofilms may form on indwelling medical devices such as prosthetic joints, heart valves and catheters, causing challenging-to-treat infections. We have previously described the 'electricidal effect', in which bacterial biofilms are decreased following exposure to direct electrical current. Herein, we sought to determine if the decreased bacterial quantities are due to detachment of biofilms or cell death and to investigate the role that reactive oxygen species (ROS) play in the observed effect. Using confocal and electron microscopy and flow cytometry, we found that direct current (DC) leads to cell death and changes in the architecture of biofilms formed by Gram-positive and Gram-negative bacteria...
2016: PloS One
https://www.readbyqxmd.com/read/27991515/a-large-ornithurine-bird-tingmiatornis-arctica-from-the-turonian-high-arctic-climatic-and-evolutionary-implications
#19
Richard K Bono, Julia Clarke, John A Tarduno, Donald Brinkman
Bird fossils from Turonian (ca. 90 Ma) sediments of Axel Heiberg Island (High Canadian Arctic) are among the earliest North American records. The morphology of a large well-preserved humerus supports identification of a new volant, possibly diving, ornithurine species (Tingmiatornis arctica). The new bird fossils are part of a freshwater vertebrate fossil assemblage that documents a period of extreme climatic warmth without seasonal ice, with minimum mean annual temperatures of 14 °C. The extreme warmth allowed species expansion and establishment of an ecosystem more easily able to support large birds, especially in fresh water bodies such as those present in the Turonian High Arctic...
December 19, 2016: Scientific Reports
https://www.readbyqxmd.com/read/27951707/electrophoretic-and-electroosmotic-motion-of-a-charged-spherical-particle-within-a-cylindrical-pore-filled-with-debye-bueche-brinkman-polymeric-solution
#20
Yu-Fan Lee, Yu-Fen Huang, Shan-Chi Tsai, Hsiao-Yun Lai, Eric Lee
Electrophoretic and electroosmotic motion of a charged spherical particle within a cylindrical pore filled with a Debye-Bueche-Brinkman (DBB) polymeric solution is investigated theoretically, which is of high relevance in capillary electrophoresis as well as micro- and nanofluidic applications involving polymeric solutions in a micro- or nanopore. The DBB model describes the rheological response of a polymeric solution with a linear polymer dissolved in a homogeneous solvent. It is a well-known non-Newtonian model in liquid physics based on rigorous theoretical derivations...
December 13, 2016: Langmuir: the ACS Journal of Surfaces and Colloids
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