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https://www.readbyqxmd.com/read/28325440/mixed-convection-peristaltic-motion-of-copper-water-nanomaterial-with-velocity-slip-effects-in-a-curved-channel
#1
T Hayat, S Farooq, A Alsaedi
BACKGROUND AND OBJECTIVE: The primary objective of present analysis is to model the peristalsis of copper-water based nanoliquid in the presence of first order velocity and thermal slip conditions in a curved channel. Mixed convection, viscous dissipation and heat generation/absorption are also accounted. METHOD: Mathematical formulation is simplified under the assumption of small Reynolds number and large wavelength. Regular perturbation technique is employed to find the solution of the resulting equations in terms of series for small Brinkman number...
April 2017: Computer Methods and Programs in Biomedicine
https://www.readbyqxmd.com/read/28320243/pilotstudie-zu-psychiatrischen-und-sozialen-aspekten-bei-kindern-und-jugendlichen-mit-fragilem-x-syndrom-frx
#2
Frank Häßler, Franziska Gaese, Michael Colla, Michael Huss, Christoph Kretschmar, Marc Brinkman, Helmut Peters, Samuel Elstner, Steffen Weirich, David Pittrow
No abstract text is available yet for this article.
March 2017: Zeitschrift Für Kinder- und Jugendpsychiatrie und Psychotherapie
https://www.readbyqxmd.com/read/28295236/pharmacology-and-therapeutics-education-in-eu-needs-harmonisation-and-modernisation-a-cross-sectional-survey-among-185-medical-schools-in-27-countries
#3
D J Brinkman, J Tichelaar, M Okorie, L Bissell, T Christiaens, R Likic, R Mačiulaitis, J Costa, E J Sanz, B I Tamba, S R Maxwell, M C Richir, M A van Agtmael
Effective teaching in pharmacology and clinical pharmacology and therapeutics (CPT) is necessary to make medical students competent prescribers. However, the current structure, delivery and assessment of CPT education in the European Union (EU) is unknown. We sent an online questionnaire to teachers with overall responsibility for CPT education in EU medical schools. Questions focused on undergraduate teaching and assessment of CPT, and students' preparedness for prescribing. 185 medical schools (64%) from 27 EU countries responded...
March 15, 2017: Clinical Pharmacology and Therapeutics
https://www.readbyqxmd.com/read/28289049/kids-in-communities-study-kics-study-protocol-a-cross-sectional-mixed-methods-approach-to-measuring-community-level-factors-influencing-early-child-development-in-australia
#4
Sharon Goldfeld, Karen Villanueva, Robert Tanton, Ilan Katz, Sally Brinkman, Geoffrey Woolcock, Billie Giles-Corti
INTRODUCTION: Healthy childhood development in the early years is critical for later adult health and well-being. Early childhood development (ECD) research has focused primarily on individual, family and school factors, but largely ignored community factors. The Kids in Communities Study (KiCS) will test and investigate community-level influences on child development across Australia. METHODS AND ANALYSIS: Cross-sectional mixed-methods study exploring community-level effects in 25 Australian local communities; selection based on community socioeconomic status (SES) and ECD using the Australian Early Development Census (AEDC), a population measure of child development, to create a local community 'diagonality type', that is, those performing better or worse (off-diagonal), or as expected (on-diagonal) on the AEDC relative to their SES...
March 13, 2017: BMJ Open
https://www.readbyqxmd.com/read/28285387/development-and-external-validation-of-preoperative-risk-models-for-operative-morbidities-after-total-gastrectomy-using-a-japanese-web-based-nationwide-registry
#5
Hirotoshi Kikuchi, Hiroaki Miyata, Hiroyuki Konno, Kinji Kamiya, Ai Tomotaki, Mitsukazu Gotoh, Go Wakabayashi, Masaki Mori
BACKGROUND: Total gastrectomy is a relatively difficult and invasive procedure among gastrointestinal surgeries, and major morbidities following total gastrectomy can be serious and fatal. This study aimed to develop and validate preoperative risk models of morbidities associated with total gastrectomy using a Japanese web-based nationwide registry. METHODS: The national clinical database was used to retrieve the records of 39,253 patients who underwent total gastrectomy in 1,841 hospitals between January 1, 2011 and December 31, 2012...
March 11, 2017: Gastric Cancer
https://www.readbyqxmd.com/read/28283098/from-bugs-to-brains-the-microbiome-in-neurological-health
#6
EDITORIAL
Kyla A McKay, Kaarina Kowalec, Fiona Brinkman, B Brett Finlay, Marc Horwitz, Amee R Manges, Lisa Osborne, Helen Tremlett
Knowledge surrounding the trillions of microbes that inhabit the human gut has bloomed exponentially in recent years, and the emerging concept of a gut-brain axis represents a major shift in how we think about neurological health. A recent workshop at the University of British Columbia, Canada brought together multi-disciplinary leaders in the field of microbiomics and brain health and aimed to serve as a springboard for future combined endeavors in these areas. This article provides the motivation for, and overview of, the workshop, and the next steps in establishing a cross-disciplinary initiative on Brain Health and the Microbiome...
February 2017: Multiple Sclerosis and related Disorders
https://www.readbyqxmd.com/read/28281048/development-of-depression-in-survivors-of-childhood-and-adolescent-cancer-a-multi-level-life-course-conceptual-framework
#7
REVIEW
Erica C Kaye, Tara M Brinkman, Justin N Baker
As therapeutic and supportive care interventions become increasingly effective, growing numbers of childhood and adolescent cancer survivors face a myriad of physical and psychological sequelae secondary to their disease and treatment. Mental health issues, in particular, present a significant problem in this unique patient population, with depression affecting a sizable number of childhood and adolescent cancer survivors. Multiple key determinants impact a survivor's risk of developing depression, with variables traversing across biologic, individual, family, community, and global levels, as well as spanning throughout the life course of human development from the preconception and prenatal periods to adulthood...
March 9, 2017: Supportive Care in Cancer: Official Journal of the Multinational Association of Supportive Care in Cancer
https://www.readbyqxmd.com/read/28272139/recent-observations-on-intolerance-of-dolutegravir-differential-causes-and-consequences
#8
Mark G J de Boer, Kees Brinkman
No abstract text is available yet for this article.
March 27, 2017: AIDS
https://www.readbyqxmd.com/read/28258722/3-acyl-dihydroflavonols-from-poplar-resins-collected-by-honey-bees-are-active-against-the-bee-pathogens-paenibacillus-larvae-and-ascosphaera-apis
#9
Michael B Wilson, Alison D Pawlus, Doug Brinkman, Gary Gardner, Adrian D Hegeman, Marla Spivak, Jerry D Cohen
Honey bees, Apis mellifera, collect antimicrobial plant resins from the environment and deposit them in their nests as propolis. This behavior is of practical concern to beekeepers since the presence of propolis in the hive has a variety of benefits, including the suppression of disease symptoms. To connect the benefits that bees derive from propolis with particular resinous plants, we determined the identity and botanical origin of propolis compounds active against bee pathogens using bioassay-guided fractionation against the bacterium Paenibacillus larvae, the causative agent of American foulbrood...
March 1, 2017: Phytochemistry
https://www.readbyqxmd.com/read/28241753/the-importance-of-registration-of-sexual-orientation-and-recognition-of-indicator-conditions-for-an-adequate-hiv-risk-assessment
#10
Ivo K Joore, Suzanne E Geerlings, Kees Brinkman, Jan E A M van Bergen, Jan M Prins
BACKGROUND: HIV testing among risk groups and guided by HIV indicator conditions (IC) is widely recommended by European guidelines. In this study we investigated how these strategies are used by general practitioners (GP) and in other healthcare settings. The objectives of our study were to describe: 1) the proportion of consultations in primary care and other healthcare settings in the five years prior to diagnosis; 2) patient and GP perspectives on the primary healthcare providers' awareness and registration of sexual orientation and ethnicity in the electronic medical record (EMR); and 3) the proportion of HIV-infected patients who had been diagnosed with an IC prior to HIV diagnosis...
February 28, 2017: BMC Infectious Diseases
https://www.readbyqxmd.com/read/28224875/-thiamine-in-patients-with-alcohol-use-disorder-and-wernicke-s-encephalopathy
#11
D J Brinkman, J K Bekema, M A Kuijenhoven, J W Wijnia, M J H J Dekker, M A van Agtmael
- Patients with alcohol use disorder frequently have a thiamine deficiency.- A potential life-threatening complication of thiamine deficiency is Wernicke's encephalopathy.- Since it is clinically difficult to recognize Wernicke's encephalopathy, this condition is often treated inadequately. - Early supplementation of thiamine is important to avoid irreversible neurological damage. - There are differences between the Dutch guidelines regarding the supplementation of thiamine for the treatment of alcoholic use disorder, and those for Wernicke's encephalopathy...
2017: Nederlands Tijdschrift Voor Geneeskunde
https://www.readbyqxmd.com/read/28212284/micronutrient-intakes-in-553-dutch-elite-and-sub-elite-athletes-prevalence-of-low-and-high-intakes-in-users-and-non-users-of-nutritional-supplements
#12
Floris Wardenaar, Naomi Brinkmans, Ingrid Ceelen, Bo Van Rooij, Marco Mensink, Renger Witkamp, Jeanne De Vries
This study investigated whether athletes meet micronutrient recommendations and whether the adequacy of their intake is related to the use of dietary supplements, sport nutrition products or a combination. Micronutrient intakes of 553 Dutch (sub-) elite athletes were assessed using web-based 24-h dietary recalls with accompanying nutritional supplement questionnaires. In the majority of both users and non-users of dietary supplements, vitamin D intake was below the estimated average requirement (AR) if supplements were not included in the analysis...
February 15, 2017: Nutrients
https://www.readbyqxmd.com/read/28208581/macronutrient-intakes-in-553-dutch-elite-and-sub-elite-endurance-team-and-strength-athletes-does-intake-differ-between-sport-disciplines
#13
Floris Wardenaar, Naomi Brinkmans, Ingrid Ceelen, Bo Van Rooij, Marco Mensink, Renger Witkamp, Jeanne De Vries
Web-based 24-h dietary recalls and questionnaires were obtained from 553 Dutch well-trained athletes. The total energy and macronutrient intake was compared between discipline-categories (endurance, team, and strength) within gender, and dietary inadequacy, i.e., too low or high intakes, according to selected recommendations and guidelines, was evaluated by applying a probability approach. On average, 2.83 days per person were reported with a mean energy intake of 2566-2985 kcal and 1997-2457 kcal per day, for men and women, respectively...
February 10, 2017: Nutrients
https://www.readbyqxmd.com/read/28207320/cardiac-findings-in-quarter-horses-with-heritable-equine-regional-dermal-asthenia
#14
Erin L Brinkman, Benjamin C Weed, Sourav S Patnaik, Bryn L Brazile, Ryan M Centini, Robert W Wills, Bari Olivier, Dodd G Sledge, Jim Cooley, Jun Liao, Ann M Rashmir-Raven
OBJECTIVE To compare biomechanical and histologic features of heart valves and echocardiographic findings between Quarter Horses with and without heritable equine regional dermal asthenia (HERDA). DESIGN Prospective case-control study. ANIMALS 41 Quarter Horses. PROCEDURES Ultimate tensile strength (UTS) of aortic and mitral valve leaflets was assessed by biomechanical testing in 5 horses with HERDA and 5 horses without HERDA (controls). Histologic evaluation of aortic and mitral valves was performed for 6 HERDA-affected and 3 control horses...
March 1, 2017: Journal of the American Veterinary Medical Association
https://www.readbyqxmd.com/read/28188471/visualization-of-vascular-injuries-in-extremity-trauma
#15
Kwitae Chong, Chenfanfu Jiang, Daniel Ram, Anand Santhanam, Demetri Terzopoulos, Peyman Benharash, Erik Dutson, Joseph Teran, Jeff D Eldredge
A tandem of particle-based computational methods is adapted to simulate injury and hemorrhage in the human body. In order to ensure anatomical fidelity, a three-dimensional model of a targeted portion of the human body is reconstructed from a dense sequence of CT scans of an anonymized patient. Skin, bone and muscular tissue are distinguished in the imaging data and assigned with their respective material properties. An injury geometry is then generated by simulating the mechanics of a ballistic projectile passing through the anatomical model with the material point method...
February 11, 2017: Medical & Biological Engineering & Computing
https://www.readbyqxmd.com/read/28181431/enhanced-oxygen-reduction-activity-on-ruddlesden-popper-phase-decorated-la0-8sr0-2feo3-%C3%AE-3d-heterostructured-cathode-for-solid-oxide-fuel-cells
#16
Tao Hong, Mingyang Zhao, Kyle Brinkman, Fanglin Chen, Changrong Xia
A new heterostructured (La,Sr)2FeO4-δ (LSF214)-La0.8Sr0.2FeO3-δ (LSF113) electrode has been synthesized to improve the oxygen reduction reaction (ORR). This new materials system was fabricated by the deposition of Sr(NO3)2 into the LSF113 framework followed by subsequent heat treatment, resulting in a new three-dimensional (3D) LSF214-LSF113 heterostructured electrode. This material system consists of a with Ruddlesden-Popper (R-P) LSF214 phase formed on the surface of the LSF113 framework. The ORR activity has been enhanced by 1 order of magnitude using the LSF214-LSF113 heterostructured electrode...
March 1, 2017: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/28166785/a-comparison-of-three-treatment-strategies-in-recent-onset-non-systemic-juvenile-idiopathic-arthritis-initial-3-months-results-of-the-best-for-kids-study
#17
P C E Hissink Muller, D M C Brinkman, D Schonenberg, Y Koopman-Keemink, I C J Brederije, W P Bekkering, T W Kuijpers, M A J van Rossum, L W A van Suijlekom-Smit, J M van den Berg, C F Allaart, R Ten Cate
BACKGROUND: Combination therapy with prednisone or etanercept may induce earlier and/or more improvement in disease activity in Disease Modifying Anti Rheumatic Drug (DMARD) naïve non-systemic Juvenile Idiopathic Arthritis (JIA) patients. Here we present three months clinical outcome of initial treatments of the BeSt-for-Kids study. METHODS: Included patients were randomized to either: 1. initial DMARD-monotherapy (sulfasalazine (SSZ) or methotrexate (MTX)), 2...
February 6, 2017: Pediatric Rheumatology Online Journal
https://www.readbyqxmd.com/read/28160404/evaluating-flow-cytometer-performance-with-weighted-quadratic-least-squares-analysis-of-led-and-multi-level-bead-data
#18
David R Parks, Faysal El Khettabi, Eric Chase, Robert A Hoffman, Stephen P Perfetto, Josef Spidlen, James C S Wood, Wayne A Moore, Ryan R Brinkman
We developed a fully automated procedure for analyzing data from LED pulses and multilevel bead sets to evaluate backgrounds and photoelectron scales of cytometer fluorescence channels. The method improves on previous formulations by fitting a full quadratic model with appropriate weighting and by providing standard errors and peak residuals as well as the fitted parameters themselves. Here we describe the details of the methods and procedures involved and present a set of illustrations and test cases that demonstrate the consistency and reliability of the results...
March 2017: Cytometry. Part A: the Journal of the International Society for Analytical Cytology
https://www.readbyqxmd.com/read/28151796/clinical-and-prognostic-features-of-patients-with-esophageal-cancer-and-multiple-primary-cancers-a-retrospective-single-institution-study
#19
Yoshifumi Baba, Naoya Yoshida, Koichi Kinoshita, Masaaki Iwatsuki, Yo-Ichi Yamashita, Akira Chikamoto, Masayuki Watanabe, Hideo Baba
OBJECTIVE: To investigate the clinical and prognostic characteristics of patients with esophageal cancer and multiple primary cancers. SUMMARY BACKGROUND DATA: Patients with esophageal cancer frequently have multiple primary cancers, the presence of which may complicate physicians' decision-making because the clinical and prognostic features of such patients remain unknown. METHODS: This retrospective single-institution study included 538 consecutive patients who had undergone resection of esophageal cancer...
February 1, 2017: Annals of Surgery
https://www.readbyqxmd.com/read/28146435/loss-of-mtss1-results-in-increased-metastatic-potential-in-pancreatic-cancer
#20
Ann E Zeleniak, Wei Huang, Mary K Brinkman, Melissa L Fishel, Reginald Hill
Pancreatic ductal adenocarcinoma (PDAC) has a 5-year survival rate of 7%. This dismal prognosis is largely due to the inability to diagnose the disease before metastasis occurs. Tumor cell dissemination occurs early in PDAC. While it is known that inflammation facilitates this process, the underlying mechanisms responsible for this progression have not been fully characterized. Here, we functionally test the role of metastasis suppressor 1 (MTSS1) in PDAC. Despite evidence showing that MTSS1 could be important for regulating metastasis in many different cancers, its function in PDAC has not been studied...
January 27, 2017: Oncotarget
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