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Hidetaka Nomura, Kimihiko Sakamoto, Takeru Sugihara, Shuhei Okamoto, Yoichi Aoki, Terumi Tanigawa, Maki Matoda, Kohei Omatsu, Hiroyuki Kanao, Kazuyoshi Kato, Kuniko Utsugi, Yuko Sugiyama, Nobuhiro Takeshima
Pegylated liposomal doxorubicin (PLD) has a good safety profile, but long-term use has been associated with development of squamous cell carcinoma of the tongue and oral cavity (SCCTO) in some patients. The study objective was to estimate the prevalence of oral leukoplakia, a known precursor of SCCTO, in patients with ovarian cancer and long-term PLD use.After approval of the institutional review board, medical record of 114 patients who were treated with PLD at our institution between January 2010 and December 2016 were retrospectively reviewed...
February 2018: Medicine (Baltimore)
Erin Brinkman, Jennifer Gambino, Alison Lee
No abstract text is available yet for this article.
February 8, 2018: Veterinary Radiology & Ultrasound
Kirsten M Pondman, Jacoline W Brinkman, Hanneke M van der Straaten, An K Stroobants, Cornelis L Harteveld
We report two families, members of which are carriers of a hemoglobin (Hb) variant previously described as Hb Nouakchott [α114(GH2)Pro→Leu; HBA1: c.344C>T; p.Pro115Leu]. In the first family of Dutch origin, the proband, a 32-year-old male and his 65-year-old father, were both carriers of Hb Nouakchott. Of the second family we tested, only the proband, a 56-year-old Dutch female was a Hb Nouakchott carrier. Hematological analyses of these cases showed the anomaly behaves as a silent Hb variant without clinical consequences...
February 6, 2018: Hemoglobin
Rachel E Brinkman-Majewski, Windee M Weiss
CONTEXT: The motivational climate created by the athletic trainer in rehabilitation may be critical in influencing athletes' intrinsic motivation and other psychosocial outcomes in the rehabilitation and the recovery process. OBJECTIVE: The purpose of this study was to examine intercollegiate athletes' perceptions of the motivational climate in the rehabilitation setting. Specifically, examining if perceptions of the motivational climate can predict athletes' levels of intrinsic motivation with rehabilitation as well as the relationship between perceptions of the motivational climate and athlete demographics (gender, starter status, athletic trainer gender, etc)...
February 6, 2018: Journal of Sport Rehabilitation
Deyang Yu, Shany E Yang, Blake R Miller, Jaclyn A Wisinski, Dawn S Sherman, Jacqueline A Brinkman, Jay L Tomasiewicz, Nicole E Cummings, Michelle E Kimple, Vincent L Cryns, Dudley W Lamming
Obesity and diabetes are major challenges to global health, and there is an urgent need for interventions that promote weight loss. Dietary restriction of methionine promotes leanness and improves metabolic health in mice and humans. However, poor long-term adherence to this diet limits its translational potential. In this study, we develop a short-term methionine deprivation (MD) regimen that preferentially reduces fat mass, restoring normal body weight and glycemic control to diet-induced obese mice of both sexes...
January 30, 2018: FASEB Journal: Official Publication of the Federation of American Societies for Experimental Biology
Joan M Korth-Bradley
The transformation of medical education, with the disappearance of sequential lectures in pharmacology, clinical pharmacology, and therapeutics, has left gaps in skills needed for new physicians and other prescribers to safely incorporate medications into clinical practice. Brinkman et al. conducted a Delphi study of European Union (EU) medical school educators and practitioners to identify core competencies needed to prescribe medications. Their findings offer directions for learned societies, such as ASCPT, to enhance pharmacology education and practice...
January 30, 2018: Clinical Pharmacology and Therapeutics
Stephanie B Dixon, Kari L Bjornard, Nicole M Alberts, Gregory T Armstrong, Tara M Brinkman, Wassim Chemaitilly, Matthew J Ehrhardt, Israel Fernandez-Pineda, Lisa M Force, Todd M Gibson, Daniel M Green, Carrie R Howell, Sue C Kaste, Anne C Kirchhoff, James L Klosky, Kevin R Krull, John T Lucas, Daniel A Mulrooney, Kirsten K Ness, Carmen L Wilson, Yutaka Yasui, Leslie L Robison, Melissa M Hudson
The population of adult survivors of childhood cancer continues to grow as survival rates improve. Although it is well established that these survivors experience various complications and comorbidities related to their malignancy and treatment, this risk is modified by many factors that are not directly linked to their cancer history. Research evaluating the influence of patient-specific demographic and genetic factors, premorbid and comorbid conditions, health behaviors, and aging has identified additional risk factors that influence cancer treatment-related toxicity and possible targets for intervention in this population...
January 29, 2018: CA: a Cancer Journal for Clinicians
Marco Vinceti, Tommaso Filippini, Cinzia Del Giovane, Gabriele Dennert, Marcel Zwahlen, Maree Brinkman, Maurice Pa Zeegers, Markus Horneber, Roberto D'Amico, Catherine M Crespi
BACKGROUND: This review is the third update of the Cochrane review "Selenium for preventing cancer". Selenium is a naturally occurring element with both nutritional and toxicological properties. Higher selenium exposure and selenium supplements have been suggested to protect against several types of cancer. OBJECTIVES: To gather and present evidence needed to address two research questions:1. What is the aetiological relationship between selenium exposure and cancer risk in humans?2...
January 29, 2018: Cochrane Database of Systematic Reviews
Pete Cadmus, Stephen F Brinkman, Melynda K May
Iron is a common pollutant in waters near coal and hard rock mine disturbances. The current 1000 µg/L total recoverable chronic criterion for iron (Fe) for protection of aquatic life in the United States was developed using very limited data in 1976 and has not been revised since. To develop a more scientifically based criterion, several chronic laboratory toxicity experiments (> 30 days) were conducted with ferric Fe at circumneutral pH on a taxonomically diverse group of organisms including brown trout (Salmo trutta), mountain whitefish (Prosopium williamsoni), boreal toad tadpoles (Bufo boreas), the oligochaete worm Lumbriculus variegatus, the mayfly Hexagenia limbata, and the planarian Dugesia dorotocephala...
January 22, 2018: Archives of Environmental Contamination and Toxicology
Gerald G Pereira, Bisheng Wu, Shakil Ahmed
We develop a gray-scale lattice Boltzmann (LB) model to study fluid flow combined with heat transfer for flow through porous media where voxels may be partially solid (or void). Heat transfer in rocks may lead to deformation, which in turn can modulate the fluid flow and so has significant contribution to rock permeability. The LB temperature field is compared to a finite difference solution of the continuum partial differential equations for fluid flow in a channel. Excellent quantitative agreement is found for both Poiseuille channel flow and Brinkman flow...
December 2017: Physical Review. E
Ali Khoynezhad, Jacob DelaRosa, Marc R Moon, William T Brinkman, Richard B Thompson, Nimesh D Desai, S Chris Malaisrie, Leonard N Girardi, Joseph E Bavaria, T Brett Reece
BACKGROUND: This study intended to evaluate the safety and hemostatic efficacy of a novel vascular sealant (Tridyne™ , Neomend, Inc., Irvine, CA) compared to an accepted adjunctive hemostatic agent applied to aortotomy and sutures lines in cardiovascular surgery. METHODS: Subjects undergoing aortic valve replacement, ascending aortic replacement and/or aortic root replacement were randomized 2:1 to Tridyne™ (n =107) or Gelfoam®+ (Gelfoam®+, Baxter Healthcare Corp...
January 11, 2018: Annals of Thoracic Surgery
Rianne de Vries, Yennece W F Dagelet, Pien Spoor, Erik Snoey, Patrick M C Jak, Paul Brinkman, Erica Dijkers, Simon K Bootsma, Fred Elskamp, Frans H C de Jongh, Eric G Haarman, Johannes C C M In 't Veen, Anke-Hilse Maitland-van der Zee, Peter J Sterk
Asthma and chronic obstructive pulmonary disease (COPD) are complex and overlapping diseases that include inflammatory phenotypes. Novel anti-eosinophilic/anti-neutrophilic strategies demand rapid inflammatory phenotyping, which might be accessible from exhaled breath.Our objective was to capture clinical/inflammatory phenotypes in patients with chronic airway disease using an electronic nose (eNose) in a training and validation set.This was a multicentre cross-sectional study in which exhaled breath from asthma and COPD patients (n=435; training n=321 and validation n=114) was analysed using eNose technology...
January 2018: European Respiratory Journal: Official Journal of the European Society for Clinical Respiratory Physiology
D Michilli, A Seymour, J W T Hessels, L G Spitler, V Gajjar, A M Archibald, G C Bower, S Chatterjee, J M Cordes, K Gourdji, G H Heald, V M Kaspi, C J Law, C Sobey, E A K Adams, C G Bassa, S Bogdanov, C Brinkman, P Demorest, F Fernandez, G Hellbourg, T J W Lazio, R S Lynch, N Maddox, B Marcote, M A McLaughlin, Z Paragi, S M Ransom, P Scholz, A P V Siemion, S P Tendulkar, P Van Rooy, R S Wharton, D Whitlow
Fast radio bursts are millisecond-duration, extragalactic radio flashes of unknown physical origin. The only known repeating fast radio burst source-FRB 121102-has been localized to a star-forming region in a dwarf galaxy at redshift 0.193 and is spatially coincident with a compact, persistent radio source. The origin of the bursts, the nature of the persistent source and the properties of the local environment are still unclear. Here we report observations of FRB 121102 that show almost 100 per cent linearly polarized emission at a very high and variable Faraday rotation measure in the source frame (varying from +1...
January 10, 2018: Nature
David J Brinkman, Jelle Tichelaar, Sanne Graaf, René H J Otten, Milan C Richir, Michiel A van Agtmael
AIMS: Prescribing errors are an important cause of patient safety incidents and are frequently caused by junior doctors. This might be because the prescribing competence of final-year medical students is poor as a result of inadequate clinical pharmacology and therapeutic (CPT) education. We reviewed the literature to investigate which prescribing competencies medical students should have acquired in order to prescribe safely and effectively, and whether these have been attained by the time they graduate...
January 8, 2018: British Journal of Clinical Pharmacology
N K Ranjit, G C Shit, D Tripathi
In most of the medical therapies, electromagnetic field plays important role to modulate the blood flow and to reduce the pain of human body. With this fact, this paper presents a mathematical model to study the peristaltic blood flow through porous microvessels in presence of electrohydrodynamics. The effects of Joule heating and different zeta potential are also considered. Darcy law is employed for porous medium. The mathematical analysis is carried out in the form of electroosmosis, flow analysis and heat transfer analysis...
December 29, 2017: Microvascular Research
Haruka Minami, Hannah R Brinkman, Shadi Nahvi, Julia H Arnsten, Monica Rivera-Mindt, David W Wetter, Erika Litvin Bloom, Lawrence H Price, Carlos Vieira, Remington Donnelly, Lauren M McClain, Katherine A Kennedy, Erica D'Aquila, M Fine, Danielle E McCarthy, J Graham Thomas, Jacki Hecht, Richard A Brown
BACKGROUND: Although individuals with psychiatric disorders are disproportionately affected by cigarette smoking, few outpatient mental health treatment facilities offer smoking cessation services. In this paper, we describe the development of a smartphone-assisted mindfulness smoking cessation intervention with contingency management (SMI-CM), as well as the design and methods of an ongoing pilot randomized controlled trial (RCT) targeting smokers receiving outpatient psychiatric treatment...
December 27, 2017: Contemporary Clinical Trials
Albina Rahim, Justin Meskas, Sibyl Drissler, Alice Yue, Anna Lorenc, Adam Laing, Namita Saran, Jacqui White, Lucie Abeler-Dörner, Adrian Hayday, Ryan R Brinkman
The rapid expansion of flow cytometry applications has outpaced the functionality of traditional manual analysis tools used to interpret flow cytometry data. Scientists are faced with the daunting prospect of manually identifying interesting cell populations in 50-dimensional datasets, equalling the complexity previously only reached in mass cytometry. Data can no longer be analyzed or interpreted fully by manual approaches. While automated gating has been the focus of intense efforts, there are many significant additional steps to the analytical pipeline (e...
December 26, 2017: Methods: a Companion to Methods in Enzymology
Yu Mi Wi, Kerryl E Greenwood-Quaintance, Cassandra L Brinkman, Jean Y H Lee, Benjamin P Howden, Robin Patel
Molecular mechanisms and characteristics of rifampin resistance in Staphylococcus epidermidis are poorly characterized, even though S. epidermidis is one of the most common nosocomial pathogens associated with indwelling medical device-related infections. The aim of this study was to investigate the evolution of rifampin resistance and to characterize the associated molecular mechanisms in S. epidermidis. Rifampin-resistant mutants from two rifampin-susceptible S. epidermidis strains, RP62A and IDRL-8883, were selected through in vitro and in vivo exposure to rifampin...
December 26, 2017: International Journal of Antimicrobial Agents
Tomoyuki Uchihara, Naoya Yoshida, Yoshifumi Baba, Taisuke Yagi, Tasuku Toihata, Eri Oda, Daisuke Kuroda, Tsugio Eto, Mayuko Ohuchi, Kenichi Nakamura, Hiroshi Sawayama, Koichi Kinoshita, Masaaki Iwatsuki, Takatsugu Ishimoto, Yasuo Sakamoto, Hideo Baba
BACKGROUND: Pulmonary morbidities after esophagectomy are still common and are a major cause of surgery-related mortality. The relationship between minimally invasive esophagectomy (MIE) and pulmonary morbidities is not clear. The current study aimed to examine the incidence of pulmonary morbidities after MIE and to clarify the associated risk factors. METHODS: Between May 2011 and December 2016, 184 patients underwent MIE for esophageal cancer. Clinical data were prospectively collected and analyzed...
December 22, 2017: Surgical Endoscopy
Courtney M Griffin, Erin L Brinkman
No abstract text is available yet for this article.
January 1, 2018: Journal of the American Veterinary Medical Association
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