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https://www.readbyqxmd.com/read/28727139/effect-of-solvent-detergent-treated-pooled-plasma-on-fibrinolysis-in-reconstituted-whole-blood
#1
Nicholas H Saadah, Pieter F van der Meer, Herm Jan M Brinkman, Dirk de Korte, Ido J Bontekoe, Herbert H Korsten, Rutger A Middelburg, Johanna G van der Bom, Martin R Schipperus
BACKGROUND: Hyperfibrinolysis has been observed in patients heavily transfused with solvent/detergent-treated pooled plasma (S/D plasma). We compared coagulation and fibrinolytic variables in blood containing S/D plasma with blood containing fresh-frozen plasma (FFP), with and without α2-antiplasmin or tranexamic acid (TXA) supplementation. STUDY DESIGN AND METHODS: Whole blood samples were reconstituted from red blood cells, platelet (PLT) concentrates, and varying mixtures of FFP and S/D plasma...
July 20, 2017: Transfusion
https://www.readbyqxmd.com/read/28721602/book-review
#2
Paul D Brinkman
No abstract text is available yet for this article.
July 18, 2017: Journal of the History of Biology
https://www.readbyqxmd.com/read/28707185/trends-in-short-term-and-1-year-mortality-in-very-elderly-intensive-care-patients-in-the-netherlands-a-retrospective-study-from-2008-to-2014
#3
Attila Karakus, Lenneke E M Haas, Sylvia Brinkman, Dylan W de Lange, Nicolette F de Keizer
PURPOSE: To describe the trends in short-term and long-term mortality in very elderly intensive care unit (ICU) patients between 2008 and 2014. METHODS: A retrospective cohort study was conducted using data from the National Intensive Care Evaluation Foundation from 31 Dutch ICUs. Generalized linear mixed-effects models were used to determine the change in adjusted short-term mortality (ICU/hospital deaths) and long-term mortality (3, 6, and 12 months after ICU admission) over the period 2008-2014 in very elderly patients and in patients less than 80 years old admitted to the ICU...
July 13, 2017: Intensive Care Medicine
https://www.readbyqxmd.com/read/28700397/successful-implementation-of-hepatitis-c-virus-treatment-in-two-large-hiv-clinics-in-amsterdam-hepatitis-c-virus-treatment-cascade-of-care
#4
Job Saris, Guido van den Berk, Daoud Ait Moha, Jan van der Meer, Kees Brinkman, Marc van der Valk
No abstract text is available yet for this article.
July 31, 2017: AIDS
https://www.readbyqxmd.com/read/28699083/a-therapy-system-for-post-traumatic-stress-disorder-using-a-virtual-agent-and-virtual-storytelling-to-reconstruct-traumatic-memories
#5
Myrthe L Tielman, Mark A Neerincx, Rafael Bidarra, Ben Kybartas, Willem-Paul Brinkman
Although post-traumatic stress disorder (PTSD) is well treatable, many people do not get the desired treatment due to barriers to care (such as stigma and cost). This paper presents a system that bridges this gap by enabling patients to follow therapy at home. A therapist is only involved remotely, to monitor progress and serve as a safety net. With this system, patients can recollect their memories in a digital diary and recreate them in a 3D WorldBuilder. Throughout the therapy, a virtual agent is present to inform and guide patients through the sessions, employing an ontology-based question module for recollecting traumatic memories to further elicit a detailed memory recollection...
August 2017: Journal of Medical Systems
https://www.readbyqxmd.com/read/28694792/context-is-everything-harmonization-of-critical-food-microbiology-descriptors-and-metadata-for-improved-food-safety-and-surveillance
#6
Emma Griffiths, Damion Dooley, Morag Graham, Gary Van Domselaar, Fiona S L Brinkman, William W L Hsiao
Globalization of food networks increases opportunities for the spread of foodborne pathogens beyond borders and jurisdictions. High resolution whole-genome sequencing (WGS) subtyping of pathogens promises to vastly improve our ability to track and control foodborne disease, but to do so it must be combined with epidemiological, clinical, laboratory and other health care data (called "contextual data") to be meaningfully interpreted for regulatory and health interventions, outbreak investigation, and risk assessment...
2017: Frontiers in Microbiology
https://www.readbyqxmd.com/read/28692530/limited-overlap-between-phylogenetic-hiv-and-hcv-clusters-illustrates-the-dynamic-sexual-network-structure-of-dutch-hiv-infected-msm
#7
Joost W Vanhommerig, Daniela Bezemer, Richard Molenkamp, Ard I Van Sighem, Colette Smit, Joop E Arends, Fanny N Lauw, Kees Brinkman, Bart J Rijnders, Astrid M Newsum, Sylvia M Bruisten, Maria Prins, Jan T Van Der Meer, Thijs J Van De Laar, Janke Schinkel
OBJECTIVE: Men who have sex with men (MSM) are at increased risk for infection with HIV-1 and hepatitis C virus (HCV). Is HIV/HCV-coinfection confined to specific HIV transmission networks? DESIGN AND METHODS: A HIV pol phylogenetic tree was constructed for 5,038 HIV-1 subtype B infected MSM from the ATHENA cohort. We investigated (i) the existence of HIV clusters with increased HCV prevalence, (ii) the HIV phylogenetic density (i.e. the number of potential HIV transmission partners) of HIV/HCV-coinfected MSM compared to HIV-infected MSM without HCV, and (iii) the overlap in HIV and HCV phylogenies using HCV NS5B sequences from 183 HIV-infected MSM with acute HCV-infection...
July 7, 2017: AIDS
https://www.readbyqxmd.com/read/28677021/a-survey-of-patients-perspectives-on-outpatient-hiv-care-in-the-netherlands
#8
Esther A N Engelhard, Colette Smit, Frank P Kroon, Pythia T Nieuwkerk, Peter Reiss, Kees Brinkman, Suzanne E Geerlings
INTRODUCTION: Responding to patients' needs and preferences is important in the delivery of outpatient care. Recent and systematically collected data reflecting human immunodeficiency virus (HIV)-infected patients' opinions on how their outpatient care should be delivered are lacking. Our aim was to identify aspects of care that people with HIV in outpatient care in The Netherlands consider important and to evaluate the extent to which the received care meets their expectations. METHODS: We measured patient preferences and experiences in a nationwide sample of HIV-infected patients using a modified, previously validated questionnaire (QUOTE-HIV)...
July 4, 2017: Infectious Diseases and Therapy
https://www.readbyqxmd.com/read/28670606/variability-in-puff-topography-and-exhaled-co-in-waterpipe-tobacco-smoking
#9
Hyoshin Kim, Marielle C Brinkman, Eva Sharma, Sydney M Gordon, Pamela I Clark
OBJECTIVES: We examined intra-individual variability in puff topography and CO measures collected during laboratory waterpipe (WP) tobacco smoking using a research-grade waterpipe (RWP). METHODS: WP smoking topography and exhaled CO measures were obtained from 10 established WP smokers in a single-blind, crossover design. Using a previously validated RWP, each participant smoked "Two Apples" WP tobacco ad libitum with a single quick-light charcoal to satiation in 3 laboratory sessions spaced at least one week apart...
October 2016: Tobacco Regulatory Science
https://www.readbyqxmd.com/read/28655592/prognostic-value-of-radiation-pneumonitis-after-stereotactic-body-radiotherapy-effect-of-pulmonary-emphysema-quantitated-using-ct%C3%A2-images
#10
Takaya Yamamoto, Noriyuki Kadoya, Yoshinao Sato, Haruo Matsushita, Rei Umezawa, Masaki Kubozono, Yojiro Ishikawa, Maiko Kozumi, Noriyoshi Takahashi, Yohei Morishita, Yu Katagiri, Kiyokazu Sato, Kengo Ito, Ken Takeda, Keiichi Jingu
BACKGROUND: The aim of this study was to determine the prognostic factors of radiation pneumonitis (RP) after stereotactic body radiotherapy (SBRT). PATIENTS AND METHODS: A total of 50 patients (36 male and 14 female) were treated with SBRT for 42 primary lung cancers and 8 metastatic lung cancers. SBRT was performed with 48 Gy in 4 fractions to the isocenter or with 40 Gy in 4 fractions covering 95% of the planning target volume. Percentage of low attenuation area (%LAA) was defined as percentage of the lung area with attenuation of -860 Hounsfield units (HU) or lower (%LAA-860) or of -960 HU or lower (%LAA-960)...
June 8, 2017: Clinical Lung Cancer
https://www.readbyqxmd.com/read/28650400/high-need-to-switch-cart-or-co-medication-with-the-initiation-of-daas-in-elderly-hiv-hcv-co-infected-patients
#11
Elise J Smolders, Colette Smit, Clara Tmm De Kanter, Anton Dofferhoff, Joop E Arends, Kees Brinkman, Bart Rijnders, Marc Van Der Valk, Peter Reiss, David M Burger
BACKGROUD: To describe the use of non-antiretroviral co-medication and combination antiretroviral therapy (cART) in HIV/hepatitis C virus (HCV) co-infected patients, and to predict the potential for drug-drug interactions (DDIs) with direct-acting antivirals (DAAs) against HCV. METHODS: This is a retrospective, cross-sectional study, using the Dutch nationwide ATHENA observational HIV cohort database. All patients with a known HIV/HCV co-infection on 1 January 2015 were included...
June 22, 2017: Journal of Acquired Immune Deficiency Syndromes: JAIDS
https://www.readbyqxmd.com/read/28649111/welcoming-wind-turbines-and-the-pimby-please-in-my-backyard-phenomenon-the-culture-of-the-machine-in-the-rural-american-midwest
#12
Joshua T Brinkman, Richard F Hirsh
This article argues that the welcoming of wind turbines in midwestern farming communities, the so-called PIMBY ("Please in My Backyard") phenomenon, constitutes only the most recent expression of a historical process of farmers forming an ultramodern identity, one that still goes largely unappreciated by relatively backward city residents. We conclude that farmers undertook a two-step process to develop a modern identity that incorporated rural values. In the first step, beginning early in the twentieth century, agrarians employed a discourse of rural capitalistic modernity to combat urban yokel stereotypes within the context of a broader rural-urban conflict...
2017: Technology and Culture
https://www.readbyqxmd.com/read/28645979/the-2015-middle-childhood-survey-mcs-of-mental-health-and-well-being-at-age-11-years-in-an-australian-population-cohort
#13
Kristin R Laurens, Stacy Tzoumakis, Kimberlie Dean, Sally A Brinkman, Miles Bore, Rhoshel K Lenroot, Maxwell Smith, Allyson Holbrook, Kim M Robinson, Robert Stevens, Felicity Harris, Vaughan J Carr, Melissa J Green
PURPOSE: The Middle Childhood Survey (MCS) was designed as a computerised self-report assessment of children's mental health and well-being at approximately 11 years of age, conducted with a population cohort of 87 026 children being studied longitudinally within the New South Wales (NSW) Child Development Study. PARTICIPANTS: School Principals provided written consent for teachers to administer the MCS in class to year 6 students at 829 NSW schools (35.0% of eligible schools)...
June 23, 2017: BMJ Open
https://www.readbyqxmd.com/read/28641380/cohort-profile-the-melbourne-collaborative-cohort-study-health-2020
#14
R L Milne, A S Fletcher, R J MacInnis, A M Hodge, A H Hopkins, J K Bassett, F J Bruinsma, B M Lynch, P A Dugué, H Jayasekara, M T Brinkman, L V Popowski, L Baglietto, G Severi, K O'Dea, J L Hopper, M C Southey, D R English, G G Giles
No abstract text is available yet for this article.
June 21, 2017: International Journal of Epidemiology
https://www.readbyqxmd.com/read/28630939/retrospective-surveillance-of-wastewater-to-examine-seasonal-dynamics-of-enterovirus-infections
#15
Nichole E Brinkman, G Shay Fout, Scott P Keely
Enteroviruses are RNA viruses that are responsible for both mild gastroenteritis and mild respiratory illnesses as well as debilitating diseases such as meningitis and myocarditis. The disease burden of enteroviruses in the United States is difficult to assess because most infections are not recorded. Since infected individuals shed enterovirus in feces and urine, surveillance of municipal wastewater can reveal the diversity of enteroviruses circulating in human populations. Therefore, monthly municipal wastewater samples were collected for 1 year and enteroviruses were quantified by reverse transcriptase quantitative PCR and identified by next-generation, high-throughput sequencing...
May 2017: MSphere
https://www.readbyqxmd.com/read/28629845/role-of-primary-motor-cortex-in-the-control-of-manual-dexterity-assessed-via-sequential-bilateral-lesion-in-the-adult-macaque-monkey-a-case-study
#16
Julie Savidan, Mélanie Kaeser, Abderraouf Belhaj-Saïf, Eric Schmidlin, Eric M Rouiller
From a case study, we describe the impact of unilateral lesion of the hand area in the primary motor cortex (M1) on manual dexterity and the role of the intact contralesional M1 in long-term functional recovery. An adult macaque monkey performed two manual dexterity tasks: (i) "modified Brinkman board" task, assessed simple precision grip versus complex precision grip, the latter involved a hand postural adjustment; (ii) "modified Klüver board" task, assessed movements ranging from power grip to precision grip, pre-shaping and grasping...
June 17, 2017: Neuroscience
https://www.readbyqxmd.com/read/28626990/exhaled-breath-profiles-in-the-monitoring-of-loss-of-control-and-clinical-recovery-in-asthma
#17
P Brinkman, M A van de Pol, M G Gerritsen, L D Bos, T Dekker, B S Smids, A Sinha, C J Majoor, M M Sneeboer, H H Knobel, T J Vink, F H de Jongh, R Lutter, P J Sterk, N Fens
BACKGROUND: Asthma is a chronic inflammatory airway disease, associated with episodes of exacerbations. Therapy with inhaled corticosteroids (ICS) targets airway inflammation, which aims to maintain and restore asthma control. Clinical features are only modestly associated with airways inflammation. Therefore, we hypothesized that exhaled volatile metabolites identify longitudinal changes between clinically stable episodes and loss of asthma control. OBJECTIVES: To determine whether exhaled volatile organic compounds (VOCs) as measured by gas-chromatography/mass-spectrometry (GC/MS) and electronic nose (eNose) technology discriminate between clinically stable and unstable episodes of asthma...
June 19, 2017: Clinical and Experimental Allergy: Journal of the British Society for Allergy and Clinical Immunology
https://www.readbyqxmd.com/read/28587893/comparison-of-estimates-of-neuronal-number-obtained-using-the-isotropic-fractionator-method-and-unbiased-stereology-in-day-old-chicks-gallus-domesticus
#18
Ayanda Ngwenya, Janae Nahirney, Ben Brinkman, Lauren Williams, Andrew N Iwaniuk
BACKGROUND: The relative size and neuronal density of brain regions are important metrics in both comparative and experimental studies in neuroscience. Consequently, it is imperative to have accurate, reliable and reproducible methods of quantifying cell number. NEW METHOD: The isotropic fractionator (IF) method estimates the number of neurons and non-neurons in the central nervous system by homogenizing tissue into discrete nuclei and determining the proportion of neurons from non-neurons using immunohistochemistry (Herculano- Herculano-Houzel and Lent, 2005)...
June 3, 2017: Journal of Neuroscience Methods
https://www.readbyqxmd.com/read/28583183/design-and-implementation-of-a-decision-aid-for-juvenile-idiopathic-arthritis-medication-choices
#19
William B Brinkman, Ellen A Lipstein, Janalee Taylor, Pamela J Schoettker, Katherine Naylor, Karla Jones, Sheetal S Vora, Catherine C Mims, Elizabeth Roth-Wojcicki, Beth Gottlieb, Nancy Griffin, Carole Lannon, Esi Morgan
BACKGROUND: Randomized trials have demonstrated the efficacy of patient decision aids to facilitate shared decision making in clinical situations with multiple medically reasonable options for treatment. However, little is known about how best to implement these tools into routine clinical practice. In addition, reliable implementation of decision aids has been elusive and spread within pediatrics has been slow. We sought to develop and reliably implement a decision aid for treatment of children with juvenile idiopathic arthritis...
June 5, 2017: Pediatric Rheumatology Online Journal
https://www.readbyqxmd.com/read/28581443/neuropeptide-ff-increases-m2-activation-and-self-renewal-of-adipose-tissue-macrophages
#20
Syed F Hassnain Waqas, Anh Cuong Hoang, Ya-Tin Lin, Grace Ampem, Hind Azegrouz, Lajos Balogh, Julianna Thuróczy, Jin-Chung Chen, Ivan C Gerling, Sorim Nam, Jong-Seok Lim, Juncal Martinez-Ibañez, José T Real, Stephan Paschke, Raphaëlle Quillet, Safia Ayachi, Frédéric Simonin, E Marion Schneider, Jacqueline A Brinkman, Dudley W Lamming, Christine M Seroogy, Tamás Röszer
The quantity and activation state of adipose tissue macrophages (ATMs) impact the development of obesity-induced metabolic diseases. Appetite-controlling hormones play key roles in obesity; however, our understanding of their effects on ATMs is limited. Here, we have shown that human and mouse ATMs express NPFFR2, a receptor for the appetite-reducing neuropeptide FF (NPFF), and that NPFFR2 expression is upregulated by IL-4, an M2-polarizing cytokine. Plasma levels of NPFF decreased in obese patients and high-fat diet-fed mice and increased following caloric restriction...
June 30, 2017: Journal of Clinical Investigation
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