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https://www.readbyqxmd.com/read/28805252/childhood-maltreatment-and-early-developmental-vulnerabilities-at-age-5%C3%A2-years
#1
Melissa J Green, Stacy Tzoumakis, Brooke McIntyre, Maina Kariuki, Kristin R Laurens, Kimberlie Dean, Marilyn Chilvers, Felicity Harris, Merran Butler, Sally A Brinkman, Vaughan J Carr
This study examined associations between maltreatment and early developmental vulnerabilities in a population sample of 68,459 children (Mage  = 5.62 years, SD = .37) drawn from the Australian state of New South Wales, using linked administrative data for the children and their parents (collected 2001-2009). Associations were estimated between (a) any maltreatment, (b) the number of maltreatment types, and (c) the timing of first reported maltreatment and vulnerability and risk status on multiple developmental domains (i...
August 14, 2017: Child Development
https://www.readbyqxmd.com/read/28800346/how-should-a-virtual-agent-present-psychoeducation-influence-of-verbal-and-textual-presentation-on-adherence
#2
Myrthe L Tielman, Mark A Neerincx, Marieke van Meggelen, Ingmar Franken, Willem-Paul Brinkman
BACKGROUND AND OBJECTIVE: With the rise of autonomous e-mental health applications, virtual agents can play a major role in improving trustworthiness, therapy outcome and adherence. In these applications, it is important that patients adhere in the sense that they perform the tasks, but also that they adhere to the specific recommendations on how to do them well. One important construct in improving adherence is psychoeducation, information on the why and how of therapeutic interventions...
August 4, 2017: Technology and Health Care: Official Journal of the European Society for Engineering and Medicine
https://www.readbyqxmd.com/read/28776042/characterization-of-legionella-species-from-watersheds-in-british-columbia-canada
#3
Michael A Peabody, Jason A Caravas, Shatavia S Morrison, Jeffrey W Mercante, Natalie A Prystajecky, Brian H Raphael, Fiona S L Brinkman
Legionella spp. present in some human-made water systems can cause Legionnaires' disease in susceptible individuals. Although legionellae have been isolated from the natural environment, variations in the organism's abundance over time and its relationship to aquatic microbiota are poorly understood. Here, we investigated the presence and diversity of legionellae through 16S rRNA gene amplicon and metagenomic sequencing of DNA from isolates collected from seven sites in three watersheds with varied land uses over a period of 1 year...
July 2017: MSphere
https://www.readbyqxmd.com/read/28767326/tracking-of-indels-by-decomposition-is-a-simple-and-effective-method-to-assess-efficiency-of-guide-rnas-in-zebrafish
#4
Christelle Etard, Swarnima Joshi, Johannes Stegmaier, Ralf Mikut, Uwe Strähle
A bottleneck in CRISPR/Cas9 genome editing is variable efficiencies of in silico-designed gRNAs. We evaluated the sensitivity of the TIDE method (Tracking of Indels by DEcomposition) introduced by Brinkman et al. in 2014 for assessing the cutting efficiencies of gRNAs in zebrafish. We show that this simple method, which involves bulk polymerase chain reaction amplification and Sanger sequencing, is highly effective in tracking well-performing gRNAs in pools of genomic DNA derived from injected embryos. The method is equally effective for tracing INDELs in heterozygotes...
August 2, 2017: Zebrafish
https://www.readbyqxmd.com/read/28758905/neuropeptide-ff-increases-m2-activation-and-self-renewal-of-adipose-tissue-macrophages
#5
Syed F Hassnain Waqas, Anh Cuong Hoang, Ya-Tin Lin, Grace Ampem, Hind Azegrouz, Lajos Balogh, Julianna Thuróczy, Jin-Chung Chen, Ivan C Gerling, Sorim Nam, Jong-Seok Lim, Juncal Martinez-Ibañez, José T Real, Stephan Paschke, Raphaëlle Quillet, Safia Ayachi, Frédéric Simonin, E Marion Schneider, Jacqueline A Brinkman, Dudley W Lamming, Christine M Seroogy, Tamás Röszer
No abstract text is available yet for this article.
July 31, 2017: Journal of Clinical Investigation
https://www.readbyqxmd.com/read/28756296/pathway-discovery-using-transcriptomic-profiles-in-adult-onset-severe-asthma
#6
Pieter-Paul Hekking, Matt J Loza, Stelios Pavlidis, Bertrand De Meulder, Diane Lefaudeux, Fred Baribaud, Charles Auffray, Ariane H Wagener, Paul Brinkman, Rene Lutter, ArunaT Bansal, Ana R Sousa, Steve Bates, Yannis Pandis, Louise J Fleming, Dominique E Shaw, Stephen J Fowler, Y Guo, Andrea Meiser, Kai Sun, Julie Corfield, Peter Howarth, Elisabeth H Bel, Ian M Adcock, K F Chung, Ratko Djukanovic, Peter J Sterk
RATIONALE: Adult-onset severe asthma is characterized by highly symptomatic disease despite high intensity asthma treatments. Understanding of the underlying pathways of this heterogeneous disease needed for the development of targeted treatments. Gene Set Variation Analysis (GSVA) is a statistical technique to identify gene profiles in heterogeneous samples. OBJECTIVE: To identify gene profiles associated with adult-onset severe asthma. METHODS: This was a cross-sectional, observational study in which adult patients with adult-onset of asthma (defined as starting at ≥18yrs old) as compared to childhood-onset severe asthma (<18 yrs) were selected from the U-BIOPRED cohort...
July 26, 2017: Journal of Allergy and Clinical Immunology
https://www.readbyqxmd.com/read/28755421/smoking-is-a-risk-factor-of-pulmonary-metastasis-in-colorectal-cancer
#7
Masashi Yahagi, Masashi Tsuruta, Hirotoshi Hasegawa, Koji Okabayashi, Naoyuki Toyoda, Nozomi Iwama, Satoru Morita, Yuko Kitagawa
AIM: The hepatic microenvironment, which may include chronic inflammation and fibrosis, is considered to contribute to the pathogenesis of liver metastases of colorectal cancer. A similar mechanism is anticipated in pulmonary metastases, although no reports are available. Smoking causes pulmonary inflammation and fibrosis. Thus, we hypothesized that smokers would be especially affected by pulmonary metastases of colorectal cancer. In this study, we attempted to clarify the impact of smoking on pulmonary metastasis of colorectal cancer...
July 29, 2017: Colorectal Disease: the Official Journal of the Association of Coloproctology of Great Britain and Ireland
https://www.readbyqxmd.com/read/28751684/lower-cretaceous-fossils-from-china-shed-light-on-the-ancestral-body-plan-of-crown-softshell%C3%A2-turtles-trionychidae-cryptodira
#8
Donald Brinkman, Márton Rabi, Lijun Zhao
Pan-trionychids or softshell turtles are a highly specialized and widespread extant group of aquatic taxa with an evolutionary history that goes back to the Early Cretaceous. The earliest pan-trionychids had already fully developed the "classic" softshell turtle morphology and it has been impossible to resolve whether they are stem members of the family or are within the crown. This has hindered our understanding of the evolution of the two basic body plans of crown-trionychids. Thus it remains unclear whether the more heavily ossified shell of the cyclanorbines or the highly reduced trionychine morphotype is the ancestral condition for softshell turtles...
July 27, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28743159/chronic-hepatitis-c-virus-infection-and-neurocognitive-function-in-adult-survivors-of-childhood-cancer
#9
Adrienne Studaway, Rohit P Ojha, Tara M Brinkman, Nan Zhang, Malek Baassiri, Pia Banerjee, Matthew J Ehrhardt, Deokumar Srivastava, Leslie L Robison, Melissa M Hudson, Kevin R Krull
BACKGROUND: Cancer survivors transfused with blood products before reliable screening for hepatitis C virus (HCV) are at risk for infection. This study examined the impact of HCV on neurocognitive function and health-related quality of life (HRQOL) among adult survivors of childhood cancer. METHODS: Neurocognitive testing was conducted for 836 adult survivors of childhood cancer (mean age, 35 years [standard deviation, 7.4 years]; time since diagnosis, 29 years [standard deviation, 6...
July 25, 2017: Cancer
https://www.readbyqxmd.com/read/28741573/novel-radiation-dose-reduction-fluoroscopic-technology-facilitates-chronic-total-occlusion-percutaneous-coronary-interventions
#10
Stephen Balter, Matthew Brinkman, Sanjog Kalra, Tamim Nazif, Manish Parikh, Ajay J Kirtane, Jeffrey Moses, Martin B Leon, Angeli Feri, Philip Green, Ziad A Ali, Ming Liao, Dimitrios Karmpaliotis
AIMS: Radiation exposure and prolonged procedure time continue to limit the complexity of CTO-PCI procedures attempted. This study aimed assess the impact of radiation-dose-limiting equipment on radiation dosage and fluoroscopic time in chronic total occlusion (CTO) percutaneous coronary interventions (PCI). METHODS AND RESULTS: Retrospective clinical and dosimetric data from diagnostic catheterizations (DXC) and CTO-PCI procedures performed on one of three variants of interventional fluoroscopic equipment were collected...
July 25, 2017: EuroIntervention
https://www.readbyqxmd.com/read/28727139/effect-of-solvent-detergent-treated-pooled-plasma-on-fibrinolysis-in-reconstituted-whole-blood
#11
Nicholas H Saadah, Pieter F van der Meer, Herm Jan M Brinkman, Dirk de Korte, Ido J Bontekoe, Herbert H Korsten, Rutger A Middelburg, Johanna G van der Bom, Martin R Schipperus
BACKGROUND: Hyperfibrinolysis has been observed in patients heavily transfused with solvent/detergent-treated pooled plasma (S/D plasma). We compared coagulation and fibrinolytic variables in blood containing S/D plasma with blood containing fresh-frozen plasma (FFP), with and without α2-antiplasmin or tranexamic acid (TXA) supplementation. STUDY DESIGN AND METHODS: Whole blood samples were reconstituted from red blood cells, platelet (PLT) concentrates, and varying mixtures of FFP and S/D plasma...
July 20, 2017: Transfusion
https://www.readbyqxmd.com/read/28721602/book-review
#12
Paul D Brinkman
No abstract text is available yet for this article.
July 18, 2017: Journal of the History of Biology
https://www.readbyqxmd.com/read/28707185/trends-in-short-term-and-1-year-mortality-in-very-elderly-intensive-care-patients-in-the-netherlands-a-retrospective-study-from-2008-to-2014
#13
Attila Karakus, Lenneke E M Haas, Sylvia Brinkman, Dylan W de Lange, Nicolette F de Keizer
PURPOSE: To describe the trends in short-term and long-term mortality in very elderly intensive care unit (ICU) patients between 2008 and 2014. METHODS: A retrospective cohort study was conducted using data from the National Intensive Care Evaluation Foundation from 31 Dutch ICUs. Generalized linear mixed-effects models were used to determine the change in adjusted short-term mortality (ICU/hospital deaths) and long-term mortality (3, 6, and 12 months after ICU admission) over the period 2008-2014 in very elderly patients and in patients less than 80 years old admitted to the ICU...
July 13, 2017: Intensive Care Medicine
https://www.readbyqxmd.com/read/28700397/successful-implementation-of-hepatitis-c-virus-treatment-in-two-large-hiv-clinics-in-amsterdam-hepatitis-c-virus-treatment-cascade-of-care
#14
Job Saris, Guido van den Berk, Daoud Ait Moha, Jan van der Meer, Kees Brinkman, Marc van der Valk
No abstract text is available yet for this article.
July 31, 2017: AIDS
https://www.readbyqxmd.com/read/28699083/a-therapy-system-for-post-traumatic-stress-disorder-using-a-virtual-agent-and-virtual-storytelling-to-reconstruct-traumatic-memories
#15
Myrthe L Tielman, Mark A Neerincx, Rafael Bidarra, Ben Kybartas, Willem-Paul Brinkman
Although post-traumatic stress disorder (PTSD) is well treatable, many people do not get the desired treatment due to barriers to care (such as stigma and cost). This paper presents a system that bridges this gap by enabling patients to follow therapy at home. A therapist is only involved remotely, to monitor progress and serve as a safety net. With this system, patients can recollect their memories in a digital diary and recreate them in a 3D WorldBuilder. Throughout the therapy, a virtual agent is present to inform and guide patients through the sessions, employing an ontology-based question module for recollecting traumatic memories to further elicit a detailed memory recollection...
August 2017: Journal of Medical Systems
https://www.readbyqxmd.com/read/28694792/context-is-everything-harmonization-of-critical-food-microbiology-descriptors-and-metadata-for-improved-food-safety-and-surveillance
#16
Emma Griffiths, Damion Dooley, Morag Graham, Gary Van Domselaar, Fiona S L Brinkman, William W L Hsiao
Globalization of food networks increases opportunities for the spread of foodborne pathogens beyond borders and jurisdictions. High resolution whole-genome sequencing (WGS) subtyping of pathogens promises to vastly improve our ability to track and control foodborne disease, but to do so it must be combined with epidemiological, clinical, laboratory and other health care data (called "contextual data") to be meaningfully interpreted for regulatory and health interventions, outbreak investigation, and risk assessment...
2017: Frontiers in Microbiology
https://www.readbyqxmd.com/read/28692530/limited-overlap-between-phylogenetic-hiv-and-hcv-clusters-illustrates-the-dynamic-sexual-network-structure-of-dutch-hiv-infected-msm
#17
Joost W Vanhommerig, Daniela Bezemer, Richard Molenkamp, Ard I Van Sighem, Colette Smit, Joop E Arends, Fanny N Lauw, Kees Brinkman, Bart J Rijnders, Astrid M Newsum, Sylvia M Bruisten, Maria Prins, Jan T Van Der Meer, Thijs J Van De Laar, Janke Schinkel
OBJECTIVE: Men who have sex with men (MSM) are at increased risk for infection with HIV-1 and hepatitis C virus (HCV). Is HIV/HCV-coinfection confined to specific HIV transmission networks? DESIGN AND METHODS: A HIV pol phylogenetic tree was constructed for 5,038 HIV-1 subtype B infected MSM from the ATHENA cohort. We investigated (i) the existence of HIV clusters with increased HCV prevalence, (ii) the HIV phylogenetic density (i.e. the number of potential HIV transmission partners) of HIV/HCV-coinfected MSM compared to HIV-infected MSM without HCV, and (iii) the overlap in HIV and HCV phylogenies using HCV NS5B sequences from 183 HIV-infected MSM with acute HCV-infection...
July 7, 2017: AIDS
https://www.readbyqxmd.com/read/28677021/a-survey-of-patients-perspectives-on-outpatient-hiv-care-in-the-netherlands
#18
Esther A N Engelhard, Colette Smit, Frank P Kroon, Pythia T Nieuwkerk, Peter Reiss, Kees Brinkman, Suzanne E Geerlings
INTRODUCTION: Responding to patients' needs and preferences is important in the delivery of outpatient care. Recent and systematically collected data reflecting human immunodeficiency virus (HIV)-infected patients' opinions on how their outpatient care should be delivered are lacking. Our aim was to identify aspects of care that people with HIV in outpatient care in The Netherlands consider important and to evaluate the extent to which the received care meets their expectations. METHODS: We measured patient preferences and experiences in a nationwide sample of HIV-infected patients using a modified, previously validated questionnaire (QUOTE-HIV)...
July 4, 2017: Infectious Diseases and Therapy
https://www.readbyqxmd.com/read/28670606/variability-in-puff-topography-and-exhaled-co-in-waterpipe-tobacco-smoking
#19
Hyoshin Kim, Marielle C Brinkman, Eva Sharma, Sydney M Gordon, Pamela I Clark
OBJECTIVES: We examined intra-individual variability in puff topography and CO measures collected during laboratory waterpipe (WP) tobacco smoking using a research-grade waterpipe (RWP). METHODS: WP smoking topography and exhaled CO measures were obtained from 10 established WP smokers in a single-blind, crossover design. Using a previously validated RWP, each participant smoked "Two Apples" WP tobacco ad libitum with a single quick-light charcoal to satiation in 3 laboratory sessions spaced at least one week apart...
October 2016: Tobacco Regulatory Science
https://www.readbyqxmd.com/read/28655592/prognostic-value-of-radiation-pneumonitis-after-stereotactic-body-radiotherapy-effect-of-pulmonary-emphysema-quantitated-using-ct%C3%A2-images
#20
Takaya Yamamoto, Noriyuki Kadoya, Yoshinao Sato, Haruo Matsushita, Rei Umezawa, Masaki Kubozono, Yojiro Ishikawa, Maiko Kozumi, Noriyoshi Takahashi, Yohei Morishita, Yu Katagiri, Kiyokazu Sato, Kengo Ito, Ken Takeda, Keiichi Jingu
BACKGROUND: The aim of this study was to determine the prognostic factors of radiation pneumonitis (RP) after stereotactic body radiotherapy (SBRT). PATIENTS AND METHODS: A total of 50 patients (36 male and 14 female) were treated with SBRT for 42 primary lung cancers and 8 metastatic lung cancers. SBRT was performed with 48 Gy in 4 fractions to the isocenter or with 40 Gy in 4 fractions covering 95% of the planning target volume. Percentage of low attenuation area (%LAA) was defined as percentage of the lung area with attenuation of -860 Hounsfield units (HU) or lower (%LAA-860) or of -960 HU or lower (%LAA-960)...
June 8, 2017: Clinical Lung Cancer
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