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https://www.readbyqxmd.com/read/28419648/the-role-of-body-image-dissatisfaction-in-the-association-between-treatment-related-scarring-or-disfigurement-and-psychological-distress-in-adult-survivors-of-childhood-cancer
#1
Stefanie C Vuotto, Rohit P Ojha, Chenghong Li, Cara Kimberg, James L Klosky, Kevin R Krull, Deo Kumar Srivastava, Leslie L Robison, Melissa M Hudson, Tara M Brinkman
PURPOSE: To examine the potential mediating role of body image dissatisfaction on the association between treatment-related scarring/disfigurement and psychological distress in adult survivors of childhood cancer. METHODS: Participants included 1,714 adult survivors of childhood cancer (mean[SD] age at evaluation = 32.4[8.0] years, time since diagnosis = 24.1[8.1] years) enrolled in the St. Jude Lifetime Cohort Study. Survivors completed measures of body image, emotional distress and posttraumatic stress symptoms (PTSS)...
April 18, 2017: Psycho-oncology
https://www.readbyqxmd.com/read/28400355/mobile-phone-delivered-cognitive-behavioral-therapy-for-insomnia-a-randomized-waitlist-controlled-trial
#2
Corine Hg Horsch, Jaap Lancee, Fiemke Griffioen-Both, Sandor Spruit, Siska Fitrianie, Mark A Neerincx, Robbert Jan Beun, Willem-Paul Brinkman
BACKGROUND: This study is one of the first randomized controlled trials investigating cognitive behavioral therapy for insomnia (CBT-I) delivered by a fully automated mobile phone app. Such an app can potentially increase the accessibility of insomnia treatment for the 10% of people who have insomnia. OBJECTIVE: The objective of our study was to investigate the efficacy of CBT-I delivered via the Sleepcare mobile phone app, compared with a waitlist control group, in a randomized controlled trial...
April 11, 2017: Journal of Medical Internet Research
https://www.readbyqxmd.com/read/28398286/a-database-of-marine-phytoplankton-abundance-biomass-and-species-composition-in-australian-waters
#3
Claire H Davies, Alex Coughlan, Gustaaf Hallegraeff, Penelope Ajani, Linda Armbrecht, Natalia Atkins, Prudence Bonham, Steve Brett, Richard Brinkman, Michele Burford, Lesley Clementson, Peter Coad, Frank Coman, Diana Davies, Jocelyn Dela-Cruz, Michelle Devlin, Steven Edgar, Ruth Eriksen, Miles Furnas, Christel Hassler, David Hill, Michael Holmes, Tim Ingleton, Ian Jameson, Sophie C Leterme, Christian Lønborg, James McLaughlin, Felicity McEnnulty, A David McKinnon, Margaret Miller, Shauna Murray, Sasi Nayar, Renee Patten, Sarah A Pausina, Tim Pritchard, Roger Proctor, Diane Purcell-Meyerink, Eric Raes, David Rissik, Jason Ruszczyk, Anita Slotwinski, Kerrie M Swadling, Katherine Tattersall, Peter Thompson, Paul Thomson, Mark Tonks, Thomas W Trull, Julian Uribe-Palomino, Anya M Waite, Rouna Yauwenas, Anthony Zammit, Anthony J Richardson
No abstract text is available yet for this article.
April 11, 2017: Scientific Data
https://www.readbyqxmd.com/read/28397711/volatile-organic-compounds-in-exhaled-breath-are-independent-of-systemic-inflammatory-syndrome-caused-by-intravenous-lipopolysaccharide-infusion-in-humans-results-from-an-experiment-in-healthy-volunteers
#4
Anna L Peters, Marije G Gerritsen, Paul Brinkman, Koos A H Zwinderman, Alexander P J Vlaar, Lieuwe D Bos
Systemic inflammatory response syndrome (SIRS) is observed during critical illness in most patients. It is defined by a clinical definition. The composition of volatile organic compounds (VOCs) in exhaled breath may change during SIRS and may thus serve as a diagnostic tool. We investigated whether exhaled breath VOCs can serve as biomarker for SIRS in a human model of endotoxemia. Eighteen healthy volunteers received 2 ng Eschericia coli lipopolysaccharide (LPS) kg(-1) body weight intravenously. Venous blood and exhaled breath were collected before infusion of LPS and every 2 h thereafter, up to 8 h after infusion...
April 11, 2017: Journal of Breath Research
https://www.readbyqxmd.com/read/28375874/immune-reconstitution-inflammatory-syndrome-associated-with-toxoplasmic-encephalitis-in-hiv-infected-patients-a-multicenter-cohort-study
#5
Ward P H van Bilsen, Charlotte H S B van den Berg, Bart J A Rijnders, Kees Brinkman, Jan W Mulder, Luc B S Gelinck, Andy I M Hoepelman, Ferdinand W N M Wit, Diederik van de Beek, Jan M Prins
OBJECTIVES: To investigate the incidence and risk factors of immune reconstitution inflammatory syndrome (IRIS) associated with toxoplasmic encephalitis (TE) in patients starting cART. DESIGN: A historical multicenter cohort study. METHODS: We included all HIV-infected patients diagnosed with TE in six Dutch hospitals between 1996 and 2016. Diagnosis of TE-IRIS was made using predefined IRIS criteria. We distinguished paradoxical TE-IRIS (worsening of underlying treated infection) from unmasking TE-IRIS (unmasking of subclinical infection after start of cART)...
April 3, 2017: AIDS
https://www.readbyqxmd.com/read/28359587/optimizing-surgical-resection-of-the-bleeding-meckel-diverticulum-in-children
#6
Jamie R Robinson, Hernan Correa, Adam S Brinkman, Harold N Lovvorn
PURPOSE: Meckel diverticula containing gastric heterotopia predispose to local hyperacidity, mucosal ulceration, and gastrointestinal bleeding in children. Eradication of acid-producing oxyntic cells is performed by either of two surgical methods: segmental enterectomy including the diverticulum or diverticulectomy only. METHODS: Retrospective review of all children having surgical resection of a Meckel diverticulum at a tertiary-referral children's hospital from 2002 to 2016 was performed...
March 23, 2017: Journal of Pediatric Surgery
https://www.readbyqxmd.com/read/28358140/a-pilot-study-on-transient-ischemic-stroke-induced-with-endothelin-1-in-the-rhesus-monkeys
#7
PeiMin Dai, Hui Huang, Lin Zhang, Jing He, XuDong Zhao, FuHan Yang, Ning Zhao, JianZhen Yang, LongJiao Ge, Yu Lin, HuaLin Yu, JianHong Wang
Endothelin-1 (ET-1), a vasoconstrictor, has recently been used to induce focal ischemia in rodents and marmoset monkeys. The rhesus monkey, however, has numerous advantages to the rodent and marmoset that make it a superior and irreplaceable animal model for studying stroke in the brain. In the present study, after mapping the preferred hand representation in two healthy male monkeys with intracortical micro-stimulation, ET-1 was microinjected into the contralateral motor cortex (M1) to its preferred hand. The monkeys had been trained in three manual dexterity tasks before the microinjection and were tested for these tasks following the ET-1 injection...
March 30, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28346508/most-women-recover-from-psychological-distress-after-postoperative-complications-following-implant-or-diep-flap-breast-reconstruction-a-prospective-long-term-follow-up-study
#8
Reinier Timman, Jessica P Gopie, J Nick Brinkman, Annelies Kleijne, Caroline Seynaeve, Marian B E Menke-Pluymers, Moniek M Ter Kuile, Aad Tibben, Marc A M Mureau
BACKGROUND: Substantial complication rates after postmastectomy breast reconstruction (BR) in breast cancer patients have been reported. Few studies have reported on the resulting psychological distress (PD) and satisfaction with the aesthetic result in relation to postoperative complications after completion of implant or DIEP flap BR. The present study investigated whether women were able to recover from complication related distress in the long term. METHODS: PD was prospectively measured using questionnaires regarding anxiety, depression and cancer distress...
2017: PloS One
https://www.readbyqxmd.com/read/28341999/immunological-memory-to-hyperphosphorylated-tau-in-asymptomatic-individuals
#9
Gabriel Pascual, Jehangir S Wadia, Xueyong Zhu, Elissa Keogh, Başak Kükrer, Jeroen van Ameijde, Hanna Inganäs, Berdien Siregar, Gerrard Perdok, Otto Diefenbach, Tariq Nahar, Imke Sprengers, Martin H Koldijk, Els C Brinkman-van der Linden, Laura A Peferoen, Heng Zhang, Wenli Yu, Xinyi Li, Michelle Wagner, Veronica Moreno, Julie Kim, Martha Costa, Kiana West, Zara Fulton, Lucy Chammas, Nancy Luckashenak, Lauren Fletcher, Trevin Holland, Carrie Arnold, R Anthony Williamson, Jeroen J Hoozemans, Adrian Apetri, Frederique Bard, Ian A Wilson, Wouter Koudstaal, Jaap Goudsmit
Several reports have described the presence of antibodies against Alzheimer's disease-associated hyperphosphorylated forms of tau in serum of healthy individuals. To characterize the specificities that can be found, we interrogated peripheral IgG(+) memory B cells from asymptomatic blood donors for reactivity to a panel of phosphorylated tau peptides using a single-cell screening assay. Antibody sequences were recovered, cloned, and expressed as full-length IgGs. In total, 52 somatically mutated tau-binding antibodies were identified, corresponding to 35 unique clonal families...
May 2017: Acta Neuropathologica
https://www.readbyqxmd.com/read/28341127/effects-of-coal-contamination-on-early-life-history-processes-of-a-reef-building-coral-acropora-tenuis
#10
Kathryn L E Berry, Mia O Hoogenboom, Diane L Brinkman, Kathryn A Burns, Andrew P Negri
Successful reproduction and larval dispersal are important for the persistence of marine invertebrate populations, and these early life history processes can be sensitive to marine pollution. Coal is emerging as a contaminant of interest due to the proximity of ports and shipping lanes to coral reefs. To assess the potential hazard of this contaminant, gametes, newly developed embryos, larvae and juveniles of the coral Acropora tenuis were exposed to a range of coal leachate, suspended coal, and coal smothering treatments...
January 15, 2017: Marine Pollution Bulletin
https://www.readbyqxmd.com/read/28339281/gate-tunable-band-structure-of-the-laalo_-3-srtio_-3-interface
#11
A E M Smink, J C de Boer, M P Stehno, A Brinkman, W G van der Wiel, H Hilgenkamp
The two-dimensional electron system at the interface between LaAlO_{3} and SrTiO_{3} has several unique properties that can be tuned by an externally applied gate voltage. In this work, we show that this gate tunability extends to the effective band structure of the system. We combine a magnetotransport study on top-gated Hall bars with self-consistent Schrödinger-Poisson calculations and observe a Lifshitz transition at a density of 2.9×10^{13}cm^{-2}. Above the transition, the carrier density of one of the conducting bands decreases with increasing gate voltage...
March 10, 2017: Physical Review Letters
https://www.readbyqxmd.com/read/28337186/genotypes-associated-with-listeria-monocytogenes-isolates-displaying-impaired-or-enhanced-tolerances-to-cold-salt-acid-or-desiccation-stress
#12
Patricia Hingston, Jessica Chen, Bhavjinder K Dhillon, Chad Laing, Claire Bertelli, Victor Gannon, Taurai Tasara, Kevin Allen, Fiona S L Brinkman, Lisbeth Truelstrup Hansen, Siyun Wang
The human pathogen Listeria monocytogenes is a large concern in the food industry where its continuous detection in food products has caused a string of recalls in North America and Europe. Most recognized for its ability to grow in foods during refrigerated storage, L. monocytogenes can also tolerate several other food-related stresses with some strains possessing higher levels of tolerances than others. The objective of this study was to use a combination of phenotypic analyses and whole genome sequencing to elucidate potential relationships between L...
2017: Frontiers in Microbiology
https://www.readbyqxmd.com/read/28325440/mixed-convection-peristaltic-motion-of-copper-water-nanomaterial-with-velocity-slip-effects-in-a-curved-channel
#13
T Hayat, S Farooq, A Alsaedi
BACKGROUND AND OBJECTIVE: The primary objective of present analysis is to model the peristalsis of copper-water based nanoliquid in the presence of first order velocity and thermal slip conditions in a curved channel. Mixed convection, viscous dissipation and heat generation/absorption are also accounted. METHOD: Mathematical formulation is simplified under the assumption of small Reynolds number and large wavelength. Regular perturbation technique is employed to find the solution of the resulting equations in terms of series for small Brinkman number...
April 2017: Computer Methods and Programs in Biomedicine
https://www.readbyqxmd.com/read/28320243/pilotstudie-zu-psychiatrischen-und-sozialen-aspekten-bei-kindern-und-jugendlichen-mit-fragilem-x-syndrom-frx
#14
Frank Häßler, Franziska Gaese, Michael Colla, Michael Huss, Christoph Kretschmar, Marc Brinkman, Helmut Peters, Samuel Elstner, Steffen Weirich, David Pittrow
No abstract text is available yet for this article.
March 2017: Zeitschrift Für Kinder- und Jugendpsychiatrie und Psychotherapie
https://www.readbyqxmd.com/read/28295236/pharmacology-and-therapeutics-education-in-eu-needs-harmonisation-and-modernisation-a-cross-sectional-survey-among-185-medical-schools-in-27-countries
#15
D J Brinkman, J Tichelaar, M Okorie, L Bissell, T Christiaens, R Likic, R Mačiulaitis, J Costa, E J Sanz, B I Tamba, S R Maxwell, M C Richir, M A van Agtmael
Effective teaching in pharmacology and clinical pharmacology and therapeutics (CPT) is necessary to make medical students competent prescribers. However, the current structure, delivery and assessment of CPT education in the European Union (EU) is unknown. We sent an online questionnaire to teachers with overall responsibility for CPT education in EU medical schools. Questions focused on undergraduate teaching and assessment of CPT, and students' preparedness for prescribing. 185 medical schools (64%) from 27 EU countries responded...
March 15, 2017: Clinical Pharmacology and Therapeutics
https://www.readbyqxmd.com/read/28289049/kids-in-communities-study-kics-study-protocol-a-cross-sectional-mixed-methods-approach-to-measuring-community-level-factors-influencing-early-child-development-in-australia
#16
Sharon Goldfeld, Karen Villanueva, Robert Tanton, Ilan Katz, Sally Brinkman, Geoffrey Woolcock, Billie Giles-Corti
INTRODUCTION: Healthy childhood development in the early years is critical for later adult health and well-being. Early childhood development (ECD) research has focused primarily on individual, family and school factors, but largely ignored community factors. The Kids in Communities Study (KiCS) will test and investigate community-level influences on child development across Australia. METHODS AND ANALYSIS: Cross-sectional mixed-methods study exploring community-level effects in 25 Australian local communities; selection based on community socioeconomic status (SES) and ECD using the Australian Early Development Census (AEDC), a population measure of child development, to create a local community 'diagonality type', that is, those performing better or worse (off-diagonal), or as expected (on-diagonal) on the AEDC relative to their SES...
March 13, 2017: BMJ Open
https://www.readbyqxmd.com/read/28285387/development-and-external-validation-of-preoperative-risk-models-for-operative-morbidities-after-total-gastrectomy-using-a-japanese-web-based-nationwide-registry
#17
Hirotoshi Kikuchi, Hiroaki Miyata, Hiroyuki Konno, Kinji Kamiya, Ai Tomotaki, Mitsukazu Gotoh, Go Wakabayashi, Masaki Mori
BACKGROUND: Total gastrectomy is a relatively difficult and invasive procedure among gastrointestinal surgeries, and major morbidities following total gastrectomy can be serious and fatal. This study aimed to develop and validate preoperative risk models of morbidities associated with total gastrectomy using a Japanese web-based nationwide registry. METHODS: The national clinical database was used to retrieve the records of 39,253 patients who underwent total gastrectomy in 1,841 hospitals between January 1, 2011 and December 31, 2012...
March 11, 2017: Gastric Cancer
https://www.readbyqxmd.com/read/28283098/from-bugs-to-brains-the-microbiome-in-neurological-health
#18
EDITORIAL
Kyla A McKay, Kaarina Kowalec, Fiona Brinkman, B Brett Finlay, Marc Horwitz, Amee R Manges, Lisa Osborne, Helen Tremlett
Knowledge surrounding the trillions of microbes that inhabit the human gut has bloomed exponentially in recent years, and the emerging concept of a gut-brain axis represents a major shift in how we think about neurological health. A recent workshop at the University of British Columbia, Canada brought together multi-disciplinary leaders in the field of microbiomics and brain health and aimed to serve as a springboard for future combined endeavors in these areas. This article provides the motivation for, and overview of, the workshop, and the next steps in establishing a cross-disciplinary initiative on Brain Health and the Microbiome...
February 2017: Multiple Sclerosis and related Disorders
https://www.readbyqxmd.com/read/28281048/development-of-depression-in-survivors-of-childhood-and-adolescent-cancer-a-multi-level-life-course-conceptual-framework
#19
REVIEW
Erica C Kaye, Tara M Brinkman, Justin N Baker
As therapeutic and supportive care interventions become increasingly effective, growing numbers of childhood and adolescent cancer survivors face a myriad of physical and psychological sequelae secondary to their disease and treatment. Mental health issues, in particular, present a significant problem in this unique patient population, with depression affecting a sizable number of childhood and adolescent cancer survivors. Multiple key determinants impact a survivor's risk of developing depression, with variables traversing across biologic, individual, family, community, and global levels, as well as spanning throughout the life course of human development from the preconception and prenatal periods to adulthood...
March 9, 2017: Supportive Care in Cancer: Official Journal of the Multinational Association of Supportive Care in Cancer
https://www.readbyqxmd.com/read/28272139/recent-observations-on-intolerance-of-dolutegravir-differential-causes-and-consequences
#20
Mark G J de Boer, Kees Brinkman
No abstract text is available yet for this article.
March 27, 2017: AIDS
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