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https://www.readbyqxmd.com/read/29244599/what-is-your-diagnosis
#1
Courtney M Griffin, Erin L Brinkman
No abstract text is available yet for this article.
January 1, 2018: Journal of the American Veterinary Medical Association
https://www.readbyqxmd.com/read/29228151/multimodal-treatment-of-the-school-aged-child-with-attention-deficit-hyperactivity-disorder
#2
Tanya E Froehlich, William B Brinkman
No abstract text is available yet for this article.
December 11, 2017: JAMA Pediatrics
https://www.readbyqxmd.com/read/29217234/outcomes-following-three-factor-inactive-prothrombin-complex-concentrate-versus-recombinant-activated-factor-vii-administration-during-cardiac-surgery
#3
Patrick C Harper, Mark M Smith, Nathan J Brinkman, Melissa A Passe, Darrell R Schroeder, Sameh M Said, Gregory A Nuttall, William C Oliver, David W Barbara
OBJECTIVE: To compare outcomes following inactive prothrombin complex concentrate (PCC) or recombinant activated factor VII (rFVIIa) administration during cardiac surgery. DESIGN: Retrospective propensity-matched analysis. SETTING: Academic tertiary-care center. PARTICIPANTS: Patients undergoing cardiac surgery requiring cardiopulmonary bypass who received either rFVIIa or the inactive 3-factor PCC. INTERVENTIONS: Outcomes following intraoperative administration of rFVIIa (263) or factor IX complex (72) as rescue therapy to treat bleeding...
July 12, 2017: Journal of Cardiothoracic and Vascular Anesthesia
https://www.readbyqxmd.com/read/29216242/the-oxyr-regulated-phnw-gene-encoding-2-aminoethylphosphonate-pyruvate-aminotransferase-helps-protect-pseudomonas-aeruginosa-from-tert-butyl-hydroperoxide
#4
Warunya Panmanee, Nisanart Charoenlap, Sopapan Atichartpongkul, Aekkapol Mahavihakanont, Matthew D Whiteside, Geoff Winsor, Fiona S L Brinkman, Skorn Mongkolsuk, Daniel J Hassett
The LysR member of bacterial transactivators, OxyR, governs transcription of genes involved in the response to H2O2 and organic (alkyl) hydroperoxides (AHP) in the Gram-negative pathogen, Pseudomonas aeruginosa. We have previously shown that organisms lacking OxyR are rapidly killed by <2 or 500 mM H2O2 in planktonic and biofilm bacteria, respectively. In this study, we first employed a bioinformatic approach to elucidate the potential regulatory breadth of OxyR by scanning the entire P. aeruginosa PAO1 genome for canonical OxyR promoter recognition sequences (ATAG-N7-CTAT-N7-ATAG-N7-CTAT)...
2017: PloS One
https://www.readbyqxmd.com/read/29207669/breath-analysis-by-gas-chromatography-mass-spectrometry-and-electronic-nose-to-screen-for-pleural-mesothelioma-a-cross-sectional-case-control-study
#5
Kevin Lamote, Paul Brinkman, Lore Vandermeersch, Matthijs Vynck, Peter J Sterk, Herman Van Langenhove, Olivier Thas, Joris Van Cleemput, Kristiaan Nackaerts, Jan P van Meerbeeck
Rationale: Malignant pleural mesothelioma (MPM) is mainly caused by previous exposure to asbestos fibers and has a poor prognosis. Due to a long latency period between exposure and diagnosis, MPM incidence is expected to peak between 2020-2025. Screening of asbestos-exposed individuals is believed to improve early detection and hence, MPM management. Recent developments focus on breath analysis for screening since breath contains volatile organic compounds (VOCs) which reflect the cell's metabolism...
October 31, 2017: Oncotarget
https://www.readbyqxmd.com/read/29205299/key-learning-outcomes-for-clinical-pharmacology-and-therapeutics-education-in-europe-a-modified-delphi-study
#6
D J Brinkman, J Tichelaar, L B Mokkink, T Christiaens, R Likic, R Maciulaitis, J Costa, E J Sanz, S R Maxwell, M C Richir, M A van Agtmael
Harmonizing clinical pharmacology and therapeutics (CPT) education in Europe is necessary to ensure that the prescribing competency of future doctors is of an uniform high standard. As there are currently no uniform requirements, our aim was to achieve consensus on key learning outcomes for undergraduate CPT education in Europe. We used a modified Delphi method consisting of three questionnaire rounds and a panel meeting. 129 experts from 27 European countries were asked to rate 307 learning outcomes. 92 experts (71%) completed all three questionnaire rounds, and 33 experts (26%) attended the meeting...
December 5, 2017: Clinical Pharmacology and Therapeutics
https://www.readbyqxmd.com/read/29201588/reminders-make-people-adhere-better-to-a-self-help-sleep-intervention
#7
Corine Horsch, Sandor Spruit, Jaap Lancee, Rogier van Eijk, Robbert Jan Beun, Mark Neerincx, Willem-Paul Brinkman
The experiment presented in this paper investigated the effects of different kinds of reminders on adherence to automated parts of a cognitive behavioural therapy for insomnia (CBT-I) delivered via a mobile device. Previous studies report that computerized health interventions can be effective. However, treatment adherence is still an issue. Reminders are a simple technique that could improve adherence. A minimal intervention prototype in the realm of sleep treatment was developed to test the effects of reminders on adherence...
2017: Health and Technology
https://www.readbyqxmd.com/read/29194939/management-of-drug-interactions-with-direct-acting-antivirals-in-dutch-hiv-hepatitis-c-virus-coinfected-patients-adequate-but-not-perfect
#8
E J Smolders, C Smit, Ctmm de Kanter, Asm Dofferhoff, J E Arends, K Brinkman, B Rijnders, M van der Valk, P Reiss, D M Burger
OBJECTIVES: Direct-acting antivirals (DAAs) for treatment of chronic hepatitis C virus (HCV) infection can cause drug-drug interactions (DDIs) with combination antiretroviral therapy (cART) and non-cART co-medication. We mapped how physicians manage DDIs between DAAs and co-medication and analysed treatment outcomes. METHODS: Data were prospectively collected as part of the ATHENA HIV observational cohort and retrospectively analysed. Dutch patients with HIV/HCV coinfection who initiated treatment with DAAs between January 2015 and May 2016 were included...
December 1, 2017: HIV Medicine
https://www.readbyqxmd.com/read/29186365/high-treatment-uptake-in-hiv-hcv-coinfected-patients-after-unrestricted-access-to-direct-acting-antivirals-in-the-netherlands
#9
Anne Boerekamps, Astrid M Newsum, Colette Smit, Joop E Arends, Clemens Richter, Peter Reiss, Bart J A Rijnders, Kees Brinkman, Marc van der Valk
Background: The Netherlands has provided unrestricted access to direct-acting antivirals (DAAs) since November 2015. We analyzed the nationwide HCV treatment uptake among HIV/HCV-coinfected patients. Methods: Data were obtained from the ATHENA HIV observational cohort in which >98% of HIV-infected patients ever registered since 1998 are included. Patients were included if they ever had 1 positive HCV RNA, did not spontaneously clear and were known to still be in care...
November 23, 2017: Clinical Infectious Diseases: An Official Publication of the Infectious Diseases Society of America
https://www.readbyqxmd.com/read/29163859/virtual-agent-mediated-appraisal-training-a-single-case-series-among-dutch-firefighters
#10
Ursula M Beer, Mark A Neerincx, Nexhmedin Morina, Willem-Paul Brinkman
Background: First responders are a prime example of professionals that are at a high risk of being exposed to traumatic experiences. Reappraisal as a coping strategy might help first responders to better cope with their emotional responses to traumatic events. Objective: This study investigated the effects of repeated sessions of a digital reappraisal training among seven firefighters. The training consisted of four sessions supported by a virtual agent, conducted at home or at work, over a two-week period in a single case series...
2017: European Journal of Psychotraumatology
https://www.readbyqxmd.com/read/29162801/characterizing-a-thermostable-cas9-for-bacterial-genome-editing-and-silencing
#11
Ioannis Mougiakos, Prarthana Mohanraju, Elleke F Bosma, Valentijn Vrouwe, Max Finger Bou, Mihris I S Naduthodi, Alex Gussak, Rudolf B L Brinkman, Richard van Kranenburg, John van der Oost
CRISPR-Cas9-based genome engineering tools have revolutionized fundamental research and biotechnological exploitation of both eukaryotes and prokaryotes. However, the mesophilic nature of the established Cas9 systems does not allow for applications that require enhanced stability, including engineering at elevated temperatures. Here we identify and characterize ThermoCas9 from the thermophilic bacterium Geobacillus thermodenitrificans T12. We show that in vitro ThermoCas9 is active between 20 and 70 °C, has stringent PAM-preference at lower temperatures, tolerates fewer spacer-protospacer mismatches than SpCas9 and its activity at elevated temperatures depends on the sgRNA-structure...
November 21, 2017: Nature Communications
https://www.readbyqxmd.com/read/29144308/numerical-simulation-of-filtration-performance-in-submerged-membrane-bioreactors-effect-of-particle-packed-structure
#12
Zhidong Wang, Kuizu Su, Tong Shu, Weihong Wang
It is widely known that the accumulation of solid matter forming a cake layer on the membrane surface is one of the major limitations of the filtration performance in submerged membrane bioreactors (SMBR). This study is focused on the influence of the cake porosity of different particle microscopic packed structures on the filtration performance of hollow fiber systems. An integrated model based on the finite element method to simulate numerically the flow in an SMBR is presented. The model coupled the Navier-Stokes and Darcy Brinkman equations to simulate a complete filtration run...
November 2017: Water Science and Technology: a Journal of the International Association on Water Pollution Research
https://www.readbyqxmd.com/read/29140443/dc-sign-polymorphisms-associated-with-risk-of-hepatitis-c-virus-infection-among-men-who-have-sex-with-men-but-not-among-injecting-drug-users
#13
Gaby S Steba, Sylvie M Koekkoek, Joost W Vanhommerig, Kees Brinkman, David Kwa, Jan T M Van Der Meer, Maria Prins, Ben Berkhout, Michael Tanck, William A Paxton, Richard Molenkamp, Janke Schinkel
We aimed to identify whether genetic polymorphisms within L-SIGN or DC-SIGN correlate with HCV susceptibility. An MSM and an IDU cohort of HCV cases and multiple-exposed uninfected controls were genotyped for numerous L-SIGN and DC-SIGN polymorphisms. DC-SIGN SNPs -139, -871 and -939 correlate with HCV acquisition in the MSM cohort only. When the same SNPs were introduced into a transcription activity assay they demonstrated a reduction in expression with predicted alteration in binding of transcription factors...
November 13, 2017: Journal of Infectious Diseases
https://www.readbyqxmd.com/read/29128680/effects-of-roughness-and-permeability-on-solute-transfer-at-the-sediment-water-interface
#14
Xu Han, Hongwei Fang, Guojian He, Danny Reible
Understanding the mechanisms of solute transfer across the sediment-water interface plays a crucial role in water quality prediction and management. In this study, different arranged particles are used to form typical rough and permeable beds. Large Eddy Simulation (LES) is used to model the solute transfer from the overlying water to sediment beds. Three rough wall turbulence regimes, i.e., smooth, transitional and rough regime, are separately considered and the effects of bed roughness on solute transfer are quantitatively analyzed...
October 29, 2017: Water Research
https://www.readbyqxmd.com/read/29120260/physiotherapists-encounters-with-obese-patients-exploring-how-embodied-approaches-gain-significance
#15
Karen Synne Groven, Kristin Heggen
BACKGROUND: Obesity is regarded as a modern lifestyle problem, causing illness, stigma, discrimination, and psychological problems. To help patients avoid these problems, physiotherapists increasingly engage in lifestyle programs specialized in weight loss. OBJECTIVE: To explore how physiotherapists' encounters with patients diagnosed as "obese" acquire significance for their development as clinicians. METHOD: The material draws on semi-structured interviews with eight physiotherapists...
November 9, 2017: Physiotherapy Theory and Practice
https://www.readbyqxmd.com/read/29112062/health-related-quality-of-life-of-people-with-hiv-an-assessment-of-patient-related-factors-and-comparison-with-other-chronic-diseasess
#16
Esther A N Engelhard, Colette Smit, Peter R Van Dijk, T Martijn Kuijper, Paulien R Wermelingg, Angelique Eam Weel, Michiel R de Boer, Kees Brinkman, Suzanne E Geerlings, Pythia T Nieuwkerk
OBJECTIVES: The health-related quality of life (HRQOL) of people with HIV is lower than in the general population, but it is unknown how it compares to that of persons with other chronic medical conditions. We compared HRQOL in HIV with HRQOL in diabetes mellitus (DM) type 1, DM type 2 and rheumatoid arthritis (RA). Additionally, we investigated factors associated with HRQOL in HIV. DESIGN: cross-sectional study METHODS:: HRQOL was measured with the Medical Outcomes Study Short Form 36-item health survey (SF-36) in a nationwide sample of people with HIV in care in the Netherlands and on cART ≥ 6 months...
November 2, 2017: AIDS
https://www.readbyqxmd.com/read/29108437/latent-profiles-of-early-developmental-vulnerabilities-in-a-new-south-wales-child-population-at-age-5%C3%A2-years
#17
Melissa J Green, Stacy Tzoumakis, Kristin R Laurens, Kimberlie Dean, Maina Kariuki, Felicity Harris, Nicole O'Reilly, Marilyn Chilvers, Sally A Brinkman, Vaughan J Carr
OBJECTIVE: Detecting the early emergence of childhood risk for adult mental disorders may lead to interventions for reducing subsequent burden of these disorders. We set out to determine classes of children who may be at risk for later mental disorder on the basis of early patterns of development in a population cohort, and associated exposures gleaned from linked administrative records obtained within the New South Wales Child Development Study. METHODS: Intergenerational records from government departments of health, education, justice and child protection were linked with the Australian Early Development Census for a state population cohort of 67,353 children approximately 5 years of age...
November 1, 2017: Australian and New Zealand Journal of Psychiatry
https://www.readbyqxmd.com/read/29099400/outcomes-of-a-multicenter-training-program-in-laparoscopic-pancreatoduodenectomy-laelaps-2
#18
Thijs de Rooij, Jony van Hilst, Baki Topal, Koop Bosscha, David J Brinkman, Michael F Gerhards, Ignace H de Hingh, Tom M Karsten, Daan J Lips, Misha D Luyer, Hendrik A Marsman, L Bengt van Rijssen, M Willemijn Steen, Olivier R Busch, Sebastiaan Festen, Marc G Besselink
OBJECTIVE: The aim of the study was to assess feasibility and outcomes of a multicenter training program in laparoscopic pancreatoduodenectomy (LPD). BACKGROUND: Whereas expert centers have reported promising outcomes of LPD, nationwide analyses have raised concerns on its safety, especially during the learning curve. Multicenter, structured LPD training programs reporting outcomes including the first procedures are lacking. No LPD had been performed in the Netherlands before this study...
November 2, 2017: Annals of Surgery
https://www.readbyqxmd.com/read/29082668/breathomics-from-exhaled-volatile-organic-compounds-in-pediatric-asthma
#19
REVIEW
Anne H Neerincx, Susanne J H Vijverberg, Lieuwe D J Bos, Paul Brinkman, Marc P van der Schee, Rianne de Vries, Peter J Sterk, Anke-Hilse Maitland-van der Zee
Asthma is the most common chronic disease in children, and is characterized by airway inflammation, bronchial hyperresponsiveness, and airflow obstruction. Asthma diagnosis, phenotyping, and monitoring are still challenging with currently available methods, such as spirometry, FE NO or sputum analysis. The analysis of volatile organic compounds (VOCs) in exhaled breath could be an interesting non-invasive approach, but has not yet reached clinical practice. This review describes the current status of breath analysis in the diagnosis and monitoring of pediatric asthma...
December 2017: Pediatric Pulmonology
https://www.readbyqxmd.com/read/29080573/management-of-type-1-diabetes
#20
REVIEW
Anne Kay Brinkman
Comprehensive type 1 diabetes management requires understanding of the pathophysiology of disease and the ability to contrast this process with type 2 diabetes. Nurses are often the first contact with patients and must be aware of the advancements in detection, therapies, and signs of complications in these patients. Individuals with type 1 diabetes are at high risk for glycemic complications caused by potentially preventable errors in medication administration, which can be mitigated with appropriate education...
December 2017: Nursing Clinics of North America
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