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https://www.readbyqxmd.com/read/28630939/retrospective-surveillance-of-wastewater-to-examine-seasonal-dynamics-of-enterovirus-infections
#1
Nichole E Brinkman, G Shay Fout, Scott P Keely
Enteroviruses are RNA viruses that are responsible for both mild gastroenteritis and mild respiratory illnesses as well as debilitating diseases such as meningitis and myocarditis. The disease burden of enteroviruses in the United States is difficult to assess because most infections are not recorded. Since infected individuals shed enterovirus in feces and urine, surveillance of municipal wastewater can reveal the diversity of enteroviruses circulating in human populations. Therefore, monthly municipal wastewater samples were collected for 1 year and enteroviruses were quantified by reverse transcriptase quantitative PCR and identified by next-generation, high-throughput sequencing...
May 2017: MSphere
https://www.readbyqxmd.com/read/28629845/role-of-primary-motor-cortex-in-the-control-of-manual-dexterity-assessed-via-sequential-bilateral-lesion-in-the-adult-macaque-monkey-a-case-study
#2
Julie Savidan, Mélanie Kaeser, Abderraouf Belhaj-Saïf, Eric Schmidlin, Eric M Rouiller
From a case study, we describe the impact of unilateral lesion of the hand area in the primary motor cortex (M1) on manual dexterity and the role of the intact contralesional M1 in long-term functional recovery. An adult macaque monkey performed two manual dexterity tasks: (i) "modified Brinkman board" task, assessed simple precision grip versus complex precision grip, the latter involved a hand postural adjustment; (ii) "modified Klüver board" task, assessed movements ranging from power grip to precision grip, pre-shaping and grasping...
June 16, 2017: Neuroscience
https://www.readbyqxmd.com/read/28626990/exhaled-breath-profiles-in-the-monitoring-of-loss-of-control-and-clinical-recovery-in-asthma
#3
Paul Brinkman, Marianne A van de Pol, Marije G Gerritsen, Lieuwe D Bos, Tamara Dekker, Barbara S Smids, Anirban Sinha, Christof J Majoor, Marlous M Sneeboer, Hugo H Knobel, Teunis J Vink, Frans H de Jongh, René Lutter, Peter J Sterk, Niki Fens
BACKGROUND: Asthma is a chronic inflammatory airway disease, associated with episodes of exacerbations. Therapy with inhaled corticosteroids (ICS) targets airway inflammation, which aims to maintain and restore asthma control. Clinical features are only modestly associated with airways inflammation. Therefore, we hypothesized that exhaled volatile metabolites identify longitudinal changes between clinically stable episodes and loss of asthma control. OBJECTIVES: To determine whether exhaled volatile organic compounds (VOCs) as measured by gas-chromatography / mass-spectrometry (GC/MS) and electronic nose (eNose) technology discriminate between clinically stable and unstable episodes of asthma...
June 19, 2017: Clinical and Experimental Allergy: Journal of the British Society for Allergy and Clinical Immunology
https://www.readbyqxmd.com/read/28587893/comparison-of-estimates-of-neuronal-number-obtained-using-the-isotropic-fractionator-method-and-unbiased-stereology-in-day-old-chicks-gallus-domesticus
#4
Ayanda Ngwenya, Janae Nahirney, Ben Brinkman, Lauren Williams, Andrew N Iwaniuk
BACKGROUND: The relative size and neuronal density of brain regions are important metrics in both comparative and experimental studies in neuroscience. Consequently, it is imperative to have accurate, reliable and reproducible methods of quantifying cell number. NEW METHOD: The isotropic fractionator (IF) method estimates the number of neurons and non-neurons in the central nervous system by homogenizing tissue into discrete nuclei and determining the proportion of neurons from non-neurons using immunohistochemistry (Herculano- Herculano-Houzel and Lent, 2005)...
June 3, 2017: Journal of Neuroscience Methods
https://www.readbyqxmd.com/read/28583183/design-and-implementation-of-a-decision-aid-for-juvenile-idiopathic-arthritis-medication-choices
#5
William B Brinkman, Ellen A Lipstein, Janalee Taylor, Pamela J Schoettker, Katherine Naylor, Karla Jones, Sheetal S Vora, Catherine C Mims, Elizabeth Roth-Wojcicki, Beth Gottlieb, Nancy Griffin, Carole Lannon, Esi Morgan
BACKGROUND: Randomized trials have demonstrated the efficacy of patient decision aids to facilitate shared decision making in clinical situations with multiple medically reasonable options for treatment. However, little is known about how best to implement these tools into routine clinical practice. In addition, reliable implementation of decision aids has been elusive and spread within pediatrics has been slow. We sought to develop and reliably implement a decision aid for treatment of children with juvenile idiopathic arthritis...
June 5, 2017: Pediatric Rheumatology Online Journal
https://www.readbyqxmd.com/read/28581443/neuropeptide-ff-increases-m2-activation-and-self-renewal-of-adipose-tissue-macrophages
#6
Syed F Hassnain Waqas, Anh Cuong Hoang, Ya-Tin Lin, Grace Ampem, Hind Azegrouz, Lajos Balogh, Julianna Thuróczy, Jin-Chung Chen, Ivan C Gerling, Sorim Nam, Jong-Seok Lim, Juncal Martinez-Ibañez, José T Real, Stephan Paschke, Raphaëlle Quillet, Safia Ayachi, Frédéric Simonin, E Marion Schneider, Jacqueline A Brinkman, Dudley W Lamming, Christine M Seroogy, Tamás Röszer
The quantity and activation state of adipose tissue macrophages (ATMs) impact the development of obesity-induced metabolic diseases. Appetite-controlling hormones play key roles in obesity; however, our understanding of their effects on ATMs is limited. Here, we have shown that human and mouse ATMs express NPFFR2, a receptor for the appetite-reducing neuropeptide FF (NPFF), and that NPFFR2 expression is upregulated by IL-4, an M2-polarizing cytokine. Plasma levels of NPFF decreased in obese patients and high-fat diet-fed mice and increased following caloric restriction...
June 5, 2017: Journal of Clinical Investigation
https://www.readbyqxmd.com/read/28562820/entropy-generation-minimization-analysis-of-active-magnetic-regenerators
#7
Paulo V Trevizoli, Jader R Barbosa
A performance assessment of active magnetocaloric regenerators using entropy generation minimization is presented. The model consists of the Brinkman-Forchheimer equation to describe the fluid flow and coupled energy equations for the fluid and solid phases. Entropy generation contributions due to axial heat conduction, fluid friction and interstitial heat transfer are considered. Based on the velocity and temperature profiles, local rates of entropy generation per unit volume were integrated to give the cycle-average entropy generation in the regenerator, which is the objective function of the optimization procedure...
May 2017: Anais da Academia Brasileira de Ciências
https://www.readbyqxmd.com/read/28545753/specific-components-of-pediatricians-medication-related-care-predict-attention-deficit-hyperactivity-disorder-symptom-improvement
#8
Jeffery N Epstein, Kelly J Kelleher, Rebecca Baum, William B Brinkman, James Peugh, William Gardner, Phil Lichtenstein, Joshua M Langberg
OBJECTIVE: The development of attention-deficit/hyperactivity disorder (ADHD) care quality measurements is a prerequisite to improving the quality of community-based pediatric care of children with ADHD. Unfortunately, the evidence base for existing ADHD care quality metrics is poor. The objective of this study was to identify which components of ADHD care best predict patient outcomes. METHOD: Parents of 372 medication-naïve children in grades 1 to 5 presenting to their community-based pediatrician (N = 195) for an ADHD-related concern and who were subsequently prescribed ADHD medication were identified...
June 2017: Journal of the American Academy of Child and Adolescent Psychiatry
https://www.readbyqxmd.com/read/28539448/virological-control-by-the-cd4-binding-site-antibody-n6-in-shiv-infected-rhesus-monkeys
#9
Boris Julg, Amarendra Pegu, Peter Abbink, Jinyan Liu, Amanda Brinkman, Katherine Molloy, Shanell Mojta, Abishek Chandrashekar, Katherine Callow, Keyun Wang, Xuejun Chen, Stephen D Schmidt, Jinghe Huang, Richard A Koup, Michael S Seaman, Brandon F Keele, John R Mascola, Mark Connors, Dan H Barouch
Passive immunotherapies against HIV-1 will most likely require broadly neutralizing antibodies (bnAb) with maximum breadth and potency to assure therapeutic efficacy. Recently, the novel CD4 binding site antibody N6 demonstrated extraordinary neutralization breadth and potency against large panels of cross clade pseudoviruses. We evaluated the in-vivo antiviral activity of N6-LS, alone or in combination with the established V3-glycan antibody PGT121, in chronically SHIV-SF162P3 infected macaques. A single dose of N6-LS suppressed plasma viral loads in 4 out of 5 animals at day 7 (mean 1...
May 24, 2017: Journal of Virology
https://www.readbyqxmd.com/read/28525576/profiling-of-volatile-organic-compounds-produced-by-clinical-aspergillus-isolates-using-gas-chromatography-mass-spectrometry
#10
M G Gerritsen, P Brinkman, N Escobar, L D Bos, K de Heer, M Meijer, H-G Janssen, H de Cock, H A B Wösten, C E Visser, M H J van Oers, P J Sterk
Volatile organic compounds (VOCs) in exhaled breath may identify the presence of invasive pulmonary aspergillosis. We aimed to detect VOC profiles emitted by in vitro cultured, clinical Aspergillus isolates using gas chromatography-mass spectrometry (GC-MS). Three clinical Aspergillus isolates and a reference strain were cultured while conidiation was prevented. Headspace samples were analyzed using a standardized method. Breath samples of patients from which the cultures were obtained were checked for the presence of the VOCs found in vitro...
May 18, 2017: Medical Mycology: Official Publication of the International Society for Human and Animal Mycology
https://www.readbyqxmd.com/read/28516170/mott-physics-beyond-brinkman-rice-scenario
#11
Marcin M Wysokiński, Michele Fabrizio
The main flaw of the well-known Brinkman-Rice description, obtained through the Gutzwiller approximation, of the paramagnetic Mott transition in the Hubbard model is in neglecting high-energy virtual processes that generate for instance the antiferromagnetic exchange J ~ t(2)/U. Here we propose a way to capture those processes by combining the Brinkman-Rice approach with a variational Schrieffer-Wolff transformation, and apply this method to study the single-band metal-to-insulator transition in a Bethe lattice with infinite coordination number, where the Gutzwiller approximation becomes exact...
April 15, 2017: Physical Review. B
https://www.readbyqxmd.com/read/28516095/david-v-procedure-in-a-patient-with-aortic-dilation-and-competent-quadricuspid-aortic-valve-are-genetics-to-blame
#12
Katherine R Hebeler, John J Squiers, Heike Baumgarten, J Michael DiMaio, William T Brinkman
Quadricuspid aortic valves (QAVs) are extremely rare. In this case study, we report a David-V valve-sparing aortic root replacement with reimplantation of a native QAV in a patient with aortic dilation, normal valve function, and a family history of aortic dissection. Microscopic pathological examination of the excised section of the aorta revealed scattered small foci of cystic medical degeneration throughout. A genetic predisposition for aortic dilation may be present in patients with QAV, even in the setting of a competent valve...
October 2016: Aorta (Stamford, Conn.)
https://www.readbyqxmd.com/read/28509645/what-is-your-diagnosis
#13
Kimberly L Gaddis, Erin L Brinkman
No abstract text is available yet for this article.
June 1, 2017: Journal of the American Veterinary Medical Association
https://www.readbyqxmd.com/read/28487567/a-robust-in-vitro-model-for-trans-lymphatic-endothelial-migration
#14
Yanbao Xiong, C Colin Brinkman, Konrad S Famulski, Emmanuel F Mongodin, Colin J Lord, Keli L Hippen, Bruce R Blazar, Jonathan S Bromberg
Trans-endothelial migration (TEM) is essential for leukocyte circulation. While much is known about trans-blood endothelial migration, far less is known about trans-lymphatic endothelial migration. We established an in vitro system to evaluate lymphatic TEM for various cell types across primary mouse and human lymphatic endothelial cells (LEC), and validated the model for the murine LEC cell line SVEC4-10. T cells exhibited enhanced unidirectional migration from the basal (abluminal) to the apical (luminal) surface across LEC, whereas for blood endothelial cells (BEC) they migrated similarly in both directions...
May 9, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28483402/doxycycline-for-outpatient-treated-acute-exacerbations-of-copd-a-randomised-double-blind-placebo-controlled-trial
#15
Patricia van Velzen, Gerben Ter Riet, Paul Bresser, Jeroen J Baars, Bob T J van den Berg, Jan W K van den Berg, Paul Brinkman, Jennece W F Dagelet, Johannes M A Daniels, Dewi R G L Groeneveld-Tjiong, René E Jonkers, Coen van Kan, Frans H Krouwels, Karin Pool, Arjan Rudolphus, Peter J Sterk, Jan M Prins
BACKGROUND: Antibiotics do not reduce mortality or short-term treatment non-response in patients receiving treatment for acute exacerbations of COPD in an outpatient setting. However, the long-term effects of antibiotics are unknown. The aim of this study was to investigate if the antibiotic doxycycline added to the oral corticosteroid prednisolone prolongs time to next exacerbation in patients with COPD receiving treatment for an exacerbation in the outpatient setting. METHODS: In this randomised double-blind placebo-controlled trial, we recruited a cohort of patients with COPD from outpatient clinics of nine teaching hospitals and three primary care centres in the Netherlands...
May 5, 2017: Lancet Respiratory Medicine
https://www.readbyqxmd.com/read/28482896/renal-transplant-patient-acceptance-of-a-self-management-support-system
#16
Wenxin Wang, Céline L van Lint, Willem-Paul Brinkman, Ton J M Rövekamp, Sandra van Dijk, Paul J M van der Boog, Mark A Neerincx
BACKGROUND: Self-management support systems (SMSS) have been proposed for renal transplant patients to increase their autonomy and reduce the number of hospital visits. For the design and implementation of such systems, it is important to understand factors influencing patients' acceptance of a SMSS. This paper aims to identify these key factors. METHODS: From literature, possible factors and related questionnaire items were identified. Afterwards, focus groups with experts and patients were conducted to adapt the items to the application domain...
May 8, 2017: BMC Medical Informatics and Decision Making
https://www.readbyqxmd.com/read/28476063/correction-of-femoral-valgus-deformity
#17
Ronald van Heerwaarden, Justus-Martijn Brinkman, Yvette Pronk
In the past two decades, the insights in the causes and development of valgus leg deformities as well as the options for treatment with corrective osteotomies have dramatically changed. New definitions for deformity analysis and planning for corrections have better defined the patients suitable for femoral valgus deformity corrections. Biomechanical research on new osteotomy methods and stability of plate fixation have provided scientific background for the development of improved surgical techniques that are more accurate, safer, and provide for quicker rehabilitation and bone healing...
May 5, 2017: Journal of Knee Surgery
https://www.readbyqxmd.com/read/28472413/islandviewer-4-expanded-prediction-of-genomic-islands-for-larger-scale-datasets
#18
Claire Bertelli, Matthew R Laird, Kelly P Williams, Britney Y Lau, Gemma Hoad, Geoffrey L Winsor, Fiona Sl Brinkman
IslandViewer (http://www.pathogenomics.sfu.ca/islandviewer/) is a widely-used webserver for the prediction and interactive visualization of genomic islands (GIs, regions of probable horizontal origin) in bacterial and archaeal genomes. GIs disproportionately encode factors that enhance the adaptability and competitiveness of the microbe within a niche, including virulence factors and other medically or environmentally important adaptations. We report here the release of IslandViewer 4, with novel features to accommodate the needs of larger-scale microbial genomics analysis, while expanding GI predictions and improving its flexible visualization interface...
May 2, 2017: Nucleic Acids Research
https://www.readbyqxmd.com/read/28457610/zika-virus-persistence-in-the-central-nervous-system-and-lymph-nodes-of-rhesus-monkeys
#19
Malika Aid, Peter Abbink, Rafael A Larocca, Michael Boyd, Ramya Nityanandam, Ovini Nanayakkara, Amanda J Martinot, Edward T Moseley, Eryn Blass, Erica N Borducchi, Abishek Chandrashekar, Amanda L Brinkman, Katherine Molloy, David Jetton, Lawrence J Tartaglia, Jinyan Liu, Katharine Best, Alan S Perelson, Rafael A De La Barrera, Mark G Lewis, Dan H Barouch
Zika virus (ZIKV) is associated with severe neuropathology in neonates as well as Guillain-Barré syndrome and other neurologic disorders in adults. Prolonged viral shedding has been reported in semen, suggesting the presence of anatomic viral reservoirs. Here we show that ZIKV can persist in cerebrospinal fluid (CSF) and lymph nodes (LN) of infected rhesus monkeys for weeks after virus has been cleared from peripheral blood, urine, and mucosal secretions. ZIKV-specific neutralizing antibodies correlated with rapid clearance of virus in peripheral blood but remained undetectable in CSF for the duration of the study...
May 4, 2017: Cell
https://www.readbyqxmd.com/read/28456608/chronic-intermittent-hypoxia-worsens-bleomycin-induced-lung-fibrosis-in-rats
#20
Rudolf K Braun, Oleg Broytman, Felix M Braun, Jacqueline A Brinkman, Andrew Clithero, Dhruvangkumar Modi, David F Pegelow, Marlowe Eldridge, Mihaela Teodorescu
Obstructive sleep apnea (OSA) has been linked to increased mortality in pulmonary fibrosis. Its key feature, chronic intermittent hypoxia (CIH), can lead to oxidative stress and inflammation, known to lead to fibrotic pathology in other organs. We tested the effects of CIH in an animal model of bleomycin-induced lung fibrosis. Sprague Dawley rats were instilled intratracheally with bleomycin (Blm) or saline (Sal), and exposed to CIH or normal air (Norm) for 9 or 30 days. Pulmonary function was tested and lungs were harvested for histological and molecular analyses...
April 27, 2017: Respiratory Physiology & Neurobiology
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