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Ambarish Gopal, Nathalia Ribeiro, John J Squiers, Elizabeth M Holper, Michael Black, Deepika Gopal, Molly Szerlip, Katherine B Harrington, Srinivas Potluri, J Michael DiMaio, David L Brown, Paul A Grayburn, Michael J Mack, William T Brinkman
A major concern regarding transcatheter aortic valve replacement (TAVR) is leaflet thrombosis. Four-dimensional computed tomography (4D-CT) is the preferred imaging modality to evaluate patients with suspected valve thrombosis. To date, the abnormal findings visualized by 4D-CT suggestive of leaflet thrombosis have lacked pathologic confirmation from a surgically explanted valve in a surviving patient. Herein, we provide pathologic confirmation of thrombus formation following surgical explantation of a thrombosed TAVR prosthesis that was initially identified by 4D-CT...
June 30, 2017: Global Cardiology Science & Practice
Jiujiang Zhu, Jingsheng Ma
A gray lattice Boltzmann model has previously been developed by the authors of this article to simulate fluid flow in porous media that contain both resolved pores and grains as well as aggregates of unresolved smaller pores and grains. In this model, a single parameter is introduced to prescribe the amount of fluid to be bounced back at each aggregate cell. This model has been shown to recover Darcy-Brinkman flow but with effective viscosity and permeability correlated through the model parameter. In this paper, we prove that the model parameter relates to the fraction of the solid phase of a sub-pore system for a specific set of bounce-back conditions...
April 11, 2018: Scientific Reports
Kunshou Zhu, Yujie Deng, Guoxing Weng, Dan Hu, Cheng Huang, Keitaro Matsumoto, Takeshi Nagayasu, Takehiko Koji, Xiongwei Zheng, Wenhui Jiang, Gen Lin, Yibin Cai, Guibin Weng, Xiaohui Chen
Smoking frequently leads to epigenetic alterations, including DNA methylation and histone modifications. The effect that smoking has on the DNA methylation levels at CCGG sites, the expression of trimethylation of histone H3 at lysine 27 (H3K27me3) and enhancer of zeste homolog 2 (EZH2), and their interactions in patients with non-small cell lung cancer (NSCLC) were analyzed. There were a total of 42 patients with NSCLC, 22 with adenocarcinomas and 20 with squamous cell carcinomas enrolled in the present study...
May 2018: Oncology Letters
Nichole E Brinkman, Eric N Villegas, Jay L Garland, Scott P Keely
Metagenomics is a powerful tool for characterizing viral composition within environmental samples, but sample and molecular processing steps can bias the estimation of viral community structure. The objective of this study is to understand the inherent variability introduced when conducting viral metagenomic analyses of wastewater and provide a bioinformatic strategy to accurately analyze sequences for viral community analyses. A standard approach using a combination of ultrafiltration, membrane filtration, and DNase treatment, and multiple displacement amplification (MDA) produced DNA preparations without any bacterial derived genes...
2018: PloS One
Haruka Minami, Erika Litvin Bloom, Hannah R Brinkman, Ana M Abrantes, Cara C Young, Richard A Brown
PURPOSE: Smoking behaviors and intent to quit have not been well studied among adolescent psychiatric patients. The current study examined the relationships between smoking-related variables (smoking status/heaviness and intent to quit), psychiatric diagnoses and symptomatology, and substance use among adolescents receiving psychiatric inpatient care. METHODS: Baseline data from a randomized controlled trial, testing the effect of a brief intervention on substance use, with 151 psychiatrically hospitalized adolescents with comorbid psychiatric and substance use disorders (diagnosed using semi-structured interviews) were examined for this study...
March 26, 2018: Drug and Alcohol Dependence
Jamie R Robinson, Nicholas H Carter, Corinne Gibson, Adam S Brinkman, Kyle Van Arendonk, Karen E Speck, Melissa E Danko, Gretchen P Jackson, Harold N Lovvorn, Martin L Blakely
PURPOSE: Standardized care via a unified surgeon preference card for pediatric appendectomy can result in significant cost reduction. The purpose of this study was to evaluate the impact of cost and outcome feedback to surgeons on value of care in an environment reluctant to adopt a standardized surgeon preference card. METHODS: Prospective observational study comparing operating room (OR) supply costs and patient outcomes for appendectomy in children with 6-month observation periods both before and after intervention...
March 8, 2018: Journal of Pediatric Surgery
Yin Ting Cheung, Raja B Khan, Wei Liu, Tara M Brinkman, Michelle N Edelmann, Wilburn E Reddick, Deqing Pei, Angela Panoskaltsis-Mortari, Deokumar Srivastava, Cheng Cheng, Leslie L Robison, Melissa M Hudson, Ching-Hon Pui, Kevin R Krull
Importance: Little is known about treatment-related neurotoxic mechanisms in children with acute lymphoblastic leukemia (ALL) treated with chemotherapy only. Objective: To examine concentration of cerebrospinal fluid (CSF) biomarkers of brain injury at ALL diagnosis and during cancer therapy and to evaluate associations with long-term neurocognitive and neuroimaging outcomes and relevant genetic polymorphisms. Design, Setting, and Participants: This prospective cohort study included 235 patients with ALL who received a chemotherapy-only protocol...
March 29, 2018: JAMA Oncology
Leah M Moody, Erin Brinkman
No abstract text is available yet for this article.
April 15, 2018: Journal of the American Veterinary Medical Association
Erin E Gill, Luisa S Chan, Geoffrey L Winsor, Neil Dobson, Raymond Lo, Shannan J Ho Sui, Bhavjinder K Dhillon, Patrick K Taylor, Raunak Shrestha, Cory Spencer, Robert E W Hancock, Peter J Unrau, Fiona S L Brinkman
BACKGROUND: Understanding the RNA processing of an organism's transcriptome is an essential but challenging step in understanding its biology. Here we investigate with unprecedented detail the transcriptome of Pseudomonas aeruginosa PAO1, a medically important and innately multi-drug resistant bacterium. We systematically mapped RNA cleavage and dephosphorylation sites that result in 5'-monophosphate terminated RNA (pRNA) using monophosphate RNA-Seq (pRNA-Seq). Transcriptional start sites (TSS) were also mapped using differential RNA-Seq (dRNA-Seq) and both datasets were compared to conventional RNA-Seq performed in a variety of growth conditions...
March 27, 2018: BMC Genomics
Yasuharu Tabara, Kazuya Setoh, Takahisa Kawaguchi, Yoshimitsu Takahashi, Shinji Kosugi, Takeo Nakayama, Fumihiko Matsuda
BACKGROUND: Cardio-ankle vascular index (CAVI) has been increasingly used as an index for arterial stiffness. However, the degree of longitudinal changes and factors affecting these changes in CAVI (ΔCAVI) are largely unknown. The aim of this study was to descriptively clarify factors associated with longitudinal ΔCAVI for the precise use of this index in the assessment of arterial stiffness. METHODS: Study participants comprised 9501 community residents (53.1 ± 13...
May 2018: Journal of Hypertension
Yi Wen, Yun Xu, Kyle S Brinkman, Lindsay Shuller-Nickles
The titanate-based hollandite structure is proposed as an effective ceramic waste form for Cs-immobilization. In this study, quantum-mechanical calculations were used to quantify the impact of A-site and B-site ordering on the structural stability of hollandite with compositions Bax Csy (Mz Ti8-z )O16 , where M = Zn2+ , Ga3+ , and Al3+ . The calculated enthalpy of formation agrees with experimental measurements of related hollandite phases from melt solution calorimetry. Ground state geometry optimizations show that, for intermediate compositions (e...
March 22, 2018: Scientific Reports
Deborah B Crom, Kirsten K Ness, Larry R Martinez, Michelle R Hebl, Leslie L Robison, Melissa M Hudson, Tara M Brinkman
PURPOSE: The purpose of this study was to investigate workplace experiences and turnover intention (consideration of leaving or changing a job) and to examine factors associated with turnover intention among survivors. METHODS: Adult survivors of childhood cancer with a history of employment (n = 289) completed measures of workplace experiences (n = 50, 18-29 years; n = 183, 30-44 years; n = 56; > 45 years of age at follow-up). Turnover intention was assessed using three items from the Job Satisfaction Scale...
March 17, 2018: Journal of Cancer Survivorship: Research and Practice
Sebastian Overmans, Mikaela Nordborg, Rubén Díaz-Rúa, Diane L Brinkman, Andrew P Negri, Susana Agustí
Exposure to polycyclic aromatic carbons (PAHs) poses a growing risk to coral reefs due to increasing shipping and petroleum extraction in tropical waters. Damaging effects of specific PAHs can be further enhanced by the presence of ultraviolet radiation, known as phototoxicity. We tested phototoxic effects of the PAHs anthracene and phenanthrene on larvae of the scleractinian coral Acropora tenuis in the presence and absence of UVA (320-400 nm). Activity of superoxide dismutase (SOD) enzyme was reduced by anthracene while phenanthrene and UVA exposure did not have any effect...
March 9, 2018: Aquatic Toxicology
Nicolas S Merle, Anne Grunenwald, Marie-Lucile Figueres, Sophie Chauvet, Marie Daugan, Samantha Knockaert, Tania Robe-Rybkine, Remi Noe, Olivia May, Marie Frimat, Nathan Brinkman, Thomas Gentinetta, Sylvia Miescher, Pascal Houillier, Veronique Legros, Florence Gonnet, Olivier P Blanc-Brude, Marion Rabant, Regis Daniel, Jordan D Dimitrov, Lubka T Roumenina
Intravascular erythrocyte destruction, accompanied by the release of pro-oxidative and pro-inflammatory components hemoglobin and heme, is a common event in the pathogenesis of numerous diseases with heterogeneous etiology and clinical features. A frequent adverse effect related to massive hemolysis is the renal injury and inflammation. Nevertheless, it is still unclear whether heme--a danger-associated molecular pattern--and ligand for TLR4 or upstream hemolysis-derived products are responsible for these effects...
2018: Frontiers in Immunology
Eva K Brinkman, Arne N Kousholt, Tim Harmsen, Christ Leemans, Tao Chen, Jos Jonkers, Bas van Steensel
Template-directed CRISPR/Cas9 editing is a powerful tool for introducing subtle mutations in genomes. However, the success rate of incorporation of the desired mutations at the target site is difficult to predict and therefore must be empirically determined. Here, we adapted the widely used TIDE method for quantification of templated editing events, including point mutations. The resulting TIDER method is a rapid, cheap and accessible tool for testing and optimization of template-directed genome editing strategies...
March 10, 2018: Nucleic Acids Research
Kevin Rey, Sukhbir Manku, Winnie Enns, Thea Van Rossum, Kevin Bushell, Ryan D Morin, Fiona S L Brinkman, Jonathan C Choy
BACKGROUND: The gut microbiota influences many immunological processes but how its disruption affects transplant rejection is poorly understood. METHODS: Interposition grafting of aortic segments was used to examine vascular rejection. The gut microbiota was disrupted in graft recipients using an antibiotic cocktail (ampicillin, vancomycin, metronidazole, neomycin sulfate) in their drinking water. RESULTS: Treatment of mice with antibiotics severely reduced total bacterial content in the intestine and disrupted the bacterial composition...
March 10, 2018: Transplantation
Julia S Anixt, Jareen Meinzen-Derr, Halley Estridge, Laura Smith, William B Brinkman
OBJECTIVE: To describe the characteristics of treatment decisions to address challenging behaviors in children with autism spectrum disorder (ASD). METHODS: Parents of children aged 4 to 15 years with ASD seen in a developmental behavioral pediatric (DBP) clinic completed validated measures to characterize their child's behaviors and their own level of stress. Parents reported their treatment priority before the visit. During the visit, we assessed shared decision making (SDM) using the Observing Patient Involvement (OPTION) scale and alignment of the clinician's treatment plan with the parent's priority...
March 12, 2018: Journal of Developmental and Behavioral Pediatrics: JDBP
Boudewijn J J Smeets, David J Brinkman, Eelco C J Horsten, Jacqueline A E Langius, Harm J T Rutten, Wouter J de Jonge, Misha D P Luyer
BACKGROUND: Myopenia (low skeletal muscle mass) is associated with an increased risk of complications following colorectal surgery, however, the underlying mechanism is poorly understood. This study investigates the effect of myopenia on the early postoperative systemic inflammatory response. MATERIALS AND METHODS: In 78 patients undergoing colorectal surgery, the presence of myopenia was preoperatively assessed using computed tomography images of the third lumbar vertebra...
March 14, 2018: Nutrition and Cancer
Simonetta Rubol, Bowen Ling, Ilenia Battiato
Flow resistance caused by vegetation is a key parameter to properly assess flood management and river restoration. However, quantifying the friction factor or any of its alternative metrics, e.g. the drag coefficient, in canopies with complex geometry has proven elusive. We explore the effect of canopy morphology on vegetated channels flow structure and resistance by treating the canopy as a porous medium characterized by an effective permeability, a property that describes the ease with which water can flow through the canopy layer...
March 13, 2018: Scientific Reports
Benedikt G Brink, Justin Meskas, Ryan R Brinkman
Motivation: Droplet digital PCR (ddPCR) is an emerging technology for quantifying DNA. By partitioning the target DNA into ∼20000 droplets, each serving as its own PCR reaction compartment, a very high sensitivity of DNA quantification can be achieved. However, manual analysis of the data is time consuming and algorithms for automated analysis of non-orthogonal, multiplexed ddPCR data are unavailable, presenting a major bottleneck for the advancement of ddPCR transitioning from low-throughput to high- throughput...
March 9, 2018: Bioinformatics
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