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https://www.readbyqxmd.com/read/29147565/operating-room-central-serous-chorioretinopathy
#1
Ahmad M Mansour, Rola Hamam
Objectives: The operating room is a place of surgical intervention with its accompanying bodily and cognitive strain on the performers. Stress in the operating room may lead to the onset of central serous chorioretinopathy as reported hereby in a retina surgeon and is labeled as operating room central serous chorioretinopathy. Methods: The same operator performed the optical coherence tomography scans on one retina surgeon. A masked observer estimated the maximal height of the subretinal fluid...
2017: SAGE open medical case reports
https://www.readbyqxmd.com/read/29133431/restoration-of-dendritic-complexity-functional-connectivity-and-diversity-of-regenerated-retinal-bipolar-neurons-in-adult-zebrafish
#2
Timothy E McGinn, Diana M Mitchell, Peter C Meighan, Natalie Partington, Dylan C Leoni, Christina E Jenkins, Michael D Varnum, Deborah L Stenkamp
Adult zebrafish (Danio rerio) are capable of regenerating retinal neurons that have been lost due to mechanical, chemical, or light damage. In the case of chemical damage, there is evidence that visually-mediated behaviors are restored following regeneration, consistent with recovery of retinal function. However, the extent to which regenerated retinal neurons attain appropriate morphologies and circuitry after such tissue-disrupting lesions has not been investigated. Adult zebrafish of both sexes were subjected to intravitreal injections of ouabain, which destroys the inner retina...
November 13, 2017: Journal of Neuroscience: the Official Journal of the Society for Neuroscience
https://www.readbyqxmd.com/read/29121367/idiopathic-retinal-vasculitis-aneurysms-and-neuroretinitis-syndrome-presenting-with-branch-retinal-artery-occlusion
#3
Jennifer A Zacharia, Adam T Chin, Carl B Rebhun, Ricardo N Louzada, Mehreen Adhi, Emily D Cole, Carlos Moreira-Neto, Nadia K Waheed, Jay S Duker
Idiopathic retinal vasculitis, aneurysms, and neuroretinitis (IRVAN) is a rare syndrome affecting the retinal and optic disc vasculature. Diffuse retinal ischemia, macular edema, and neovascularization may lead to bilateral vision loss. The authors report a case of a 36-year-old woman presenting with branch retinal artery occlusion (BRAO) in her right eye who was subsequently diagnosed with IRVAN syndrome. She was treated with panretinal photocoagulation for peripheral retinal ischemia and pars plana vitrectomy for vitreous hemorrhage...
November 1, 2017: Ophthalmic Surgery, Lasers & Imaging Retina
https://www.readbyqxmd.com/read/29121366/nonconforming-deep-focal-choroidal-excavation-in-a-patient-with-choroidal-osteoma-a-diagnostic-dilemma
#4
Rohan Chawla, Shorya Vardhan Azad, Brijesh Takkar, Anu Sharma, Bibhuti Kashyap
Evolution of an osteoma may result in neurosensory detachment, deossification, and choroidal neovascularization (CNV). The authors report a rare case of choroidal osteoma with CNV associated with a deep non-conforming focal choroidal excavation. [Ophthalmic Surg Lasers Imaging Retina. 2017;48:944-947.].
November 1, 2017: Ophthalmic Surgery, Lasers & Imaging Retina
https://www.readbyqxmd.com/read/29121365/irvine-gass-macular-edema-responding-to-the-combination-of-oral-mineralocorticoid-receptor-antagonist-with-dexamethasone-drops
#5
Alexandre Matet, Alejandra Daruich, Francine Behar-Cohen
Long-lasting postoperative macular edema is a therapeutic challenge. The authors report an efficient combination therapy of oral mineralocorticoid receptor antagonists (eplerenone [Inspra; Pfizer, New York City, NY] or spironolactone, 25 mg/day to 50 mg/day) and topical dexamethasone (four times/day and progressive dose tapering) in three refractory cases following complex cataract or retinal detachment surgery. In Case 1, central macular thickness (CMT) decreased from 523 μm to 214 μm and visual acuity (VA) improved from 20/200 to 20/50 during a 6-month period...
November 1, 2017: Ophthalmic Surgery, Lasers & Imaging Retina
https://www.readbyqxmd.com/read/29121363/treatment-of-ipilimumab-induced-vogt-koyanagi-harada-syndrome-with-oral-dexamethasone
#6
Matthew T Witmer
The author presents a retrospective case report of a 54-year-old male with ipilimumab (Yervoy; Bristol-Myers Squibb, New York City, NY)-induced Vogt-Koyanagi-Harada Disease (VKH), which consisted of uveitis, optic neuritis, and choroiditis that was successfully treated with oral dexamethasone. The patient demonstrated resolution of uveitis, optic neuritis, and choroiditis 1 month following initiation of oral dexamethasone. Ipilimumab is a recently approved therapy for malignant melanoma. Reports have identified that VKH disease is a potential side effect of the medication...
November 1, 2017: Ophthalmic Surgery, Lasers & Imaging Retina
https://www.readbyqxmd.com/read/29109902/assessment-of-spectral-domain-optical-coherence-tomography-findings-in-three-cases-of-x-linked-juvenile-retinoschisis-in-the-same-family
#7
Sibel Doğuizi, Mehmet Ali Şekeroğlu, Salih Çolak, Mustafa Alpaslan Anayol, Pelin Yılmazbaş
X-linked juvenile retinoschisis (XLRS) is an X-linked hereditary retinal dystrophy characterized by splitting of the neurosensory retina. On fundus examination, the macula often has a spoke wheel appearance with foveal cystic lesions, and separation of the retinal layers is typical on spectral-domain optical coherence tomography (SD-OCT). Patients with XLRS can exhibit different clinical courses, stages, and SD-OCT findings, even among members of the same family. SD-OCT is an important imaging method that allows us to achieve more detailed information about XLRS...
October 2017: Turkish Journal of Ophthalmology
https://www.readbyqxmd.com/read/29059089/refractory-giant-cell-arteritis-complicated-by-vision-loss-from-optic-atrophy-and-maculopathy-associated-with-pachymeningitis
#8
Jorge A Uribe, Ishita Aggarwal, Juthamat Witthayaweerasak, Y Joyce Liao, Gerald J Berry, Umesh K Sab, Cornelia M Weyand
BACKGROUND: We describe a 75-year-old woman who experienced vision loss in her left eye due to biopsy-proven giant cell arteritis (GCA). She subsequently developed pachymeningitis causing refractory headaches and bilateral optic neuropathy and maculopathy. METHODS: Case report with literature review. RESULTS: Eighteen months after the initial diagnosis of GCA, imaging studies in our patient demonstrated pachymeningeal enhancement, and meningeal biopsy confirmed lymphoplasmacytic tissue infiltrates with low frequencies of IgG4+ plasma cells...
October 20, 2017: Journal of Neuro-ophthalmology: the Official Journal of the North American Neuro-Ophthalmology Society
https://www.readbyqxmd.com/read/29058245/ocular-findings-in-a-patient-with-oculofaciocardiodental-ofcd-syndrome-and-a-novel-bcor-pathogenic-variant
#9
Yujia Zhou, Antonina Wojcik, Victoria R Sanders, Bahram Rahmani, Sudhi P Kurup
PURPOSE: To report a case of OFCD associated with a de novo BCOR pathogenic variant and highlight the ocular findings and possible mechanisms. METHODS: A retrospective chart review of the patient's ocular and systemic findings was performed. The patient underwent diagnostic whole exome sequencing (WES). RESULTS: The patient had a comprehensive eye exam in infancy demonstrating bilateral congenital cataracts consisting of posterior lenticonus with a posterior cortical opacity...
October 22, 2017: International Ophthalmology
https://www.readbyqxmd.com/read/29051833/anatomical-and-functional-correlation-in-susac-syndrome-multimodal-imaging-assessment
#10
Alexandre G B Azevedo, Luiz H Lima, Léo Müller, Flávio Rezende Filho, Cláudio Zett, André Maia, Luiz Roisman
BACKGROUND: Susac's syndrome (SuS) is an uncommon disease characterized by retinal microangiopathy that may be assessed more accurately with optical coherence tomography angiography (OCTA), a new imaging technique which provides a retinal microvasculature map. The purpose of this case report is to describe the multimodal imaging findings of SuS correlating OCTA with functional tests. CASE PRESENTATION: Retrospective review of one case with clinical and imaging evidence of SuS...
2017: International Journal of Retina and Vitreous
https://www.readbyqxmd.com/read/29044082/rickettsial-retinitis-direct-bacterial-infection-or-an-immune-mediated-response
#11
Rohan Chawla, Gadkar Amit Pundlik, Rama Chaudhry, Chandan Thakur
Infectious retinitis postfebrile illness is known to be caused by chikungunya, dengue, West Nile virus, Bartonella, Lyme's disease, Rift Valley fever, rickettsia, Herpes viruses etc. Rickettsia is Gram-negative bacteria transmitted by arthropods vectors. Ocular involvement is common including conjunctivitis, keratitis, anterior uveitis, panuveitis, retinitis, retinal vascular changes, and optic nerve involvement. Retinitis lesions in rickettsia can occur because of an immunological response to the bacteria or because of direct invasion and proliferation of bacteria in the inner retina...
October 2017: Indian Journal of Ophthalmology
https://www.readbyqxmd.com/read/29043565/eccentric-macular-hole-after-pars-plana-vitrectomy-for-epiretinal-membrane-without-internal-limiting-membrane-peeling-a-case-report
#12
Christina Garnavou-Xirou, Tina Xirou, Stamatina Kabanarou, Ilias Gkizis, Stavros Velissaris, Irini Chatziralli
INTRODUCTION: Postoperative eccentric macular hole formation is an uncommon complication after pars plana vitrectomy (PPV) without internal limiting membrane (ILM) peeling for the treatment of epiretinal membrane (ERM). We present a case of eccentric macular hole formation after PPV for ERM without ILM peeling. CASE REPORT: A 68-year-old male patient presented with ERM and visual acuity of 6/24 in his left eye. He underwent 23-gauge PPV without ILM peeling for treatment of ERM...
December 2017: Ophthalmology and Therapy
https://www.readbyqxmd.com/read/29034157/endoscope-assisted-vitrectomy-in-the-management-of-retinal-detachment-with-corneal-opacity
#13
Yu-Fang Huang, Chia-Jen Chang
A 51-year-old male who had suffered from right eye rhegmatogenous retinal detachment with proliferative vitreoretinopathy received surgical treatments which included the following procedures: lens extraction, scleral buckle, vitrectomy, membrane peeling, photocoagulation, and silicone oil injection. The presenting visual acuity of the right eye was light perception. Slit-lamp examination revealed corneal opacity without a visible fundus. B-scan ultrasonography revealed retinal detachment. Endoscope-assisted vitrectomy was then performed in December 2014...
July 2017: Taiwan Journal of Ophthalmology
https://www.readbyqxmd.com/read/29030949/microrna-expression-in-the-neural-retina-focus-on-m%C3%A3-ller-glia
#14
REVIEW
Heberto Quintero, Mónica Lamas
The neural retina hosts a unique specialized type of macroglial cell that not only preserves retinal homeostasis, function, and integrity but also may serve as a source of new neurons during regenerative processes: the Müller cell. Precise microRNA-driven mechanisms of gene regulation impel and direct the processes of Müller glia lineage acquisition from retinal progenitors during development, the triggering of their response to retinal degeneration and, in some cases, Müller cell reprogramming and regenerative events...
October 14, 2017: Journal of Neuroscience Research
https://www.readbyqxmd.com/read/29028736/superficial-and-deep-capillary-ischemia-as-a-presenting-sign-of-retinal-vasculopathy-with-cerebral-leukoencephalopathy-and-systemic-manifestations
#15
Aaron Nagiel, Robert A Lalane, Joanna C Jen, Allan E Kreiger
PURPOSE: The aim of this study was to investigate the presenting sign of retinal vasculopathy with cerebral leukoencephalopathy and systemic manifestations, a rare autosomal dominant condition caused by mutations in the TREX1 gene, and to explore the potential efficacy of bevacizumab in preventing capillary occlusions. METHODS: Observational case report with the use of ultra-widefield fluorescein angiography, optical coherence tomography, and optical coherence tomography angiography...
October 12, 2017: Retinal Cases & Brief Reports
https://www.readbyqxmd.com/read/29022557/two-childhood-pheochromocytoma-cases-due-to-von-hippel-lindau-disease-one-associated-with-pancreatic-neuroendocrine-tumor-a-rare-manifestation
#16
Aydilek Dağdeviren Çakır, Hande Turan, Ayça Aykut, Asude Durmaz, Oya Ercan, Olcay Evliyaoğlu
(VHL) disease is an autosomal dominantly inherited disorder characterized by hemangioblastomas of retina and central nervous system (CNS); renal cysts, clear cell carcinoma; PCC; endolymphatic sac tumors; cystadenomas of the epididymis in males, broad ligament of uterus in females; pancreatic cysts, cystadenomas and neuroendocrine tumors. We here report two cases of VHL disease presented with PCC as the first manifestation. Hemangioblastoma of CNS in the first case and PNET in the second case developed during follow- up and led to the diagnosis of VHL disease...
October 12, 2017: Journal of Clinical Research in Pediatric Endocrinology
https://www.readbyqxmd.com/read/29020430/acute-exudative-polymorphous-paraneoplastic-vitelliform-maculopathy-managed-with-intravitreal-aflibercept
#17
Kaan Gündüz, Gökçen Çöndü, Carol L Shields
The authors report on two patients with bilateral acute exudative polymorphous paraneoplastic vitelliform maculopathy (AEPPVM) treated with intravitreal aflibercept (Eylea; Regeneron, Tarrytown, NY [marketed locally in Turkey by Bayer]). Underlying malignancy had been treated in each case, including breast carcinoma in one case and colon carcinoma in the other case. A macular vitelliform lesion was noted in the right eye and atrophic retinal pigment epithelial (RPE) changes were noted in the left eye of each case...
October 1, 2017: Ophthalmic Surgery, Lasers & Imaging Retina
https://www.readbyqxmd.com/read/29020427/cabbage-leaf-inverted-flap-ilm-peeling-for-macular-hole-a-novel-technique
#18
Ajay Aurora, Anisha Seth, Neeraj Sanduja
Large macular holes have poor surgical outcomes with conventional vitrectomy and internal limiting membrane (ILM) peeling surgery, but improved anatomical closure rates have been seen with an inverted ILM flap technique. Many studies have been reported with modifications in the original inverted ILM technique that help in better retention of the flap over the macular hole. The authors describe a new technique of inverted ILM flap in a case of chronic, large, full-thickness macular holes, in which multiple ILM flaps were inverted over each other and the hole-like cabbage leaves...
October 1, 2017: Ophthalmic Surgery, Lasers & Imaging Retina
https://www.readbyqxmd.com/read/28988945/neurodegeneration-in-diabetic-retinopathy-potential-for-novel-therapies
#19
Alistair J Barber, Basma Baccouche
The complex pathology of diabetic retinopathy (DR) affects both vascular and neural tissue. The characteristics of neurodegeneration are well-described in animal models but have more recently been confirmed in the clinical setting, mostly by using non-invasive imaging approaches such as spectral domain optical coherence tomography (SD-OCT). The most frequent observations report loss of tissue in the nerve fiber layer and inner plexiform layer, confirming earlier findings from animal models. In several cases the reduction in inner retinal layers is reported in patients with little evidence of vascular lesions or macular edema, suggesting that degenerative loss of neural tissue in the inner retina can occur after relatively short durations of diabetes...
October 14, 2017: Vision Research
https://www.readbyqxmd.com/read/28985803/flashes-and-floaters-a-survey-of-canadian-ophthalmology-residents-practice-patterns
#20
Parnian Arjmand, Bernard Hurley
BACKGROUND: Residents are often the first point of contact in assessing patients who present with "flashes and floaters" in the emergency ophthalmology clinic. Most often, these symptoms are attributed to a posterior vitreous detachment (PVD), which may be associated with a retinal tear in up to 14% of cases. A proper peripheral retinal exam is, thus, imperative, and techniques other than scleral depression may not be sufficient. We conducted a cross-sectional survey of Canadian ophthalmology residents-in-training to understand the current resident practice patterns for examination of the peripheral retina...
October 2017: Canadian Journal of Ophthalmology. Journal Canadien D'ophtalmologie
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