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https://www.readbyqxmd.com/read/28325865/venetoclax-and-obinutuzumab-in-chronic-lymphocytic-leukemia
#1
Kirsten Fischer, Othman Al-Sawaf, Anna-Maria Fink, Mark Dixon, Jasmin Bahlo, Simon Warburton, Thomas J Kipps, Robert Weinkove, Sue Robinson, Till Seiler, Stephen Opat, Carolyn Owen, Javier López, Kathryn Humphrey, Rod Humerickhouse, Eugen Tausch, Lukas Frenzel, Barbara Eichhorst, Clemens-M Wendtner, Stephan Stilgenbauer, Anton W Langerak, Jacque J M van Dongen, Sebastian Boettcher, Matthias Ritgen, Valentin Goede, Mehrdad Mobasher, Michael Hallek
No abstract text is available yet for this article.
March 21, 2017: Blood
https://www.readbyqxmd.com/read/28283831/patient-satisfaction-in-an-outpatient-parenteral-antimicrobial-therapy-opat-unit-practising-predominantly-self-administration-of-antibiotics-with-elastomeric-pumps
#2
L Saillen, L Arensdorff, E Moulin, R Voumard, C Cochet, N Boillat-Blanco, C Gardiol, S de Vallière
Self-administration of antibiotics using elastomeric pumps has become the most frequently used treatment modality at the outpatient parenteral antimicrobial therapy (OPAT) unit of the University Hospital of Lausanne. However, it remains unknown how comfortable patients feel using this mode of treatment. A questionnaire was offered to all patients treated at the OPAT unit between June 2014 and December 2015. The questionnaire was distributed to 188 patients and 112 questionnaires were returned. Seventy-one patients were treated by self-administration, 21 attended the OPAT unit on a daily basis, and 20 received their antibiotics from home-care nurses...
March 11, 2017: European Journal of Clinical Microbiology & Infectious Diseases
https://www.readbyqxmd.com/read/28279155/acute-dental-infections-managed-in-an-outpatient-parenteral-antibiotic-program-setting-prospective-analysis-and-public-health-implications
#3
William J Connors, Heidi H Rabie, Rafael L Figueiredo, Donna L Holton, Michael D Parkins
BACKGROUND: The number of Acute Dental Infections (ADI) presenting for emergency department (ED) care are steadily increasing. Outpatient Parenteral Antibiotic Therapy (OPAT) programs are increasingly utilized as an alternative cost-effective approach to the management of serious infectious diseases but their role in the management of severe ADI is not established. This study aims to address this knowledge gap through evaluation of ADI referrals to a regional OPAT program in a large Canadian center...
March 9, 2017: BMC Infectious Diseases
https://www.readbyqxmd.com/read/28215410/predicting-the-risk-of-osteopenia-for-women-aged-40-55-years
#4
Jen-Hau Chen, Yen-Ching Chen, Min-Kuang Tsai, Jeng-Min Chiou, Wen-Chung Lee, Chwen-Keng Tsao, Keh-Sung Tsai, Wei-Chu Chie
BACKGROUND/PURPOSE: Osteoporosis has been linked to an increased fracture risk and subsequent mortality in the later life. Previous prediction models have focused on osteoporosis in postmenopausal women; however, a prediction tool for osteopenia is needed. Our objective was to establish a prediction model for osteopenia risk in women aged 40-55 years. METHODS: This was a cross-sectional study. A total of 1350 Taiwanese women aged 40-55 years were recruited from a health checkup center from 2009 to 2010...
February 15, 2017: Journal of the Formosan Medical Association, Taiwan Yi Zhi
https://www.readbyqxmd.com/read/28158637/antibiotic-stability-related-to-temperature-variations-in-elastomeric-pumps-used-for-outpatient-parenteral-antimicrobial-therapy-opat
#5
Rachel Voumard, Niklas Van Neyghem, Camille Cochet, Céline Gardiol, Laurent Decosterd, Thierry Buclin, Serge de Valliere
No abstract text is available yet for this article.
February 3, 2017: Journal of Antimicrobial Chemotherapy
https://www.readbyqxmd.com/read/28132552/service-development-of-a-nurse-led-community-based-picc-insertion-service
#6
Eva Bedford, Dee Waterhouse
Patients receiving intravenous therapy require reliable venous access. Typically patients with poor peripheral access or requiring long-term treatment from an outpatient antibiotic therapy (OPAT) service need to receive secondary care input for safe central line placement, and radiological confirmation of the correct line tip placement where necessary, if treatment is to proceed as planned. Technological developments that enable accurate ultrasound-guided vein selection and electrocardiograph (ECG)-guided central line tip placement have eliminated the need for radiological or fluoroscopic confirmation of correct tip placement for peripherally placed central catheters (PICCs)...
January 26, 2017: British Journal of Nursing: BJN
https://www.readbyqxmd.com/read/28110617/characterization-of-drug-related-problems-occurring-in-patients-receiving-outpatient-antimicrobial-therapy
#7
Cory M Hale, Jeffrey M Steele, Robert W Seabury, Christopher D Miller
BACKGROUND: Despite the numerous benefits of outpatient parenteral antimicrobial therapy (OPAT), appreciable risks of drug-related problems (DRPs) exist. No studies to date comprehensively assess DRPs in this population. OBJECTIVES: Objectives of this study were to (1) characterize the frequency and types of DRPs experienced by patients discharged on OPAT and (2) determine the fraction of adverse drug reactions (ADRs) resulting in hospital readmission or emergency department (ED) presentation and changes in therapy...
January 1, 2017: Journal of Pharmacy Practice
https://www.readbyqxmd.com/read/28077673/outpatient-parenteral-antibiotic-therapy-opat-in-asia-missing-an-opportunity
#8
Dale Fisher, Jessica Michaels, Ryota Hase, Jing Zhang, Sushila Kataria, Benedict Sim, Joseph Kay-Yan Tsang, James Pollard, Monica Chan, Subramanian Swaminathan
OBJECTIVES: Healthcare facilities internationally have grown outpatient parenteral antibiotic administration services for the last few decades. The literature contains publications from dozens of countries describing systematized processes with specialist oversight and their levels of service provision and outcomes. Such descriptions are absent in the majority of Asian countries. We sought to elucidate the extent and nature of outpatient parenteral antibiotic therapy (OPAT) in Asia and to consider the ramifications and opportunities for improvement METHODS: Utilizing colleagues and their personal networks, we surveyed healthcare facilities across 17 countries in Asia to ascertain the current means (if any) of providing OPAT...
January 10, 2017: Journal of Antimicrobial Chemotherapy
https://www.readbyqxmd.com/read/28073966/extended-stability-of-antimicrobial-agents-in-administration-devices
#9
Abi Jenkins, Tim Hills, Mark Santillo, Mark Gilchrist
BACKGROUND: Outpatient parenteral antimicrobial therapy (OPAT) is an established approach to patient care. A lack of data on antimicrobial stability within administration devices is a barrier to service expansion, and poses an antimicrobial stewardship dilemma. Often broad-spectrum, long half-life agents are used instead of narrow-spectrum agents, which need more frequent administration, but could possibly be used if stability data were available. OBJECTIVES: To complete a comprehensive literature review of published antimicrobial stability data, and assess these against a nationally recognized minimum dataset for medicines compounded into administration devices...
January 10, 2017: Journal of Antimicrobial Chemotherapy
https://www.readbyqxmd.com/read/28030483/antibiotic-classification-and-indication-review-for-the-infusion-nurse
#10
Kelly M Percival
Outpatient parenteral antimicrobial therapy (OPAT) has become an increasingly common practice for the treatment of infections. The infusion nurse plays a vital role in administering, monitoring, and educating patients about parenteral antibiotics, while bridging communication between the patient and OPAT team. It is important for the infusion nurse to know common indications, adverse effects, monitoring parameters, and the mechanism of action for antibiotics used in OPAT to provide optimal patient care. This review includes those antibiotics, which are frequently administered or recently approved with a high likelihood of being used in OPAT...
January 2017: Journal of Infusion Nursing: the Official Publication of the Infusion Nurses Society
https://www.readbyqxmd.com/read/27898208/-design-and-implementation-of-an-outpatient-parenteral-antimicrobial-therapy-program-in-primary-care-the-experience-at-a-second-level-hospital
#11
M Ruiz-Campuzano, E García-Vázquez, J J Hernández-Roca, J Gómez-Gómez, M Canteras-Jordana, E Mené-Fenor, A Hernández-Torres, A Peláez-Ballesta
OBJECTIVE: Outpatient parenteral antimicrobial therapy (OPAT) programs are a good assistance option in a wide variety of infectious diseases. Our aim was to design and implement an OPAT program in the area of influence of a second-level hospital, with no Home Hospitalization Service available, being necessary close collaboration between hospitalization and Primary Care teams, describe our cohort, analyse the antimicrobial treatment indicated and evaluate the prognostic and risk factors associated with readmission and mortality...
November 28, 2016: Revista Española de Quimioterapia: Publicación Oficial de la Sociedad Española de Quimioterapia
https://www.readbyqxmd.com/read/27821624/the-utility-of-a-blood-culture-database-to-identify-patients-suitable-for-outpatient-parenteral-antibiotic-treatment
#12
Mark Melzer, Liana Macpherson, Catherine Welch
BACKGROUND: The clinical and cost-effectiveness of outpatient parenteral antimicrobial therapy (OPAT) services are well described. We used a blood culture database as a novel approach to case finding and determined its utility in identifying inpatients suitable for OPAT. METHODS: From December 2012 to November 2013, consecutive adult inpatients with bacteraemia, and those recruited to OPAT, were prospectively studied. Univariate and multivariate logistic regression analysis were used to investigate the association between bacteraemic patient characteristics and OPAT recruitment...
November 7, 2016: Postgraduate Medical Journal
https://www.readbyqxmd.com/read/27820968/safety-and-efficacy-of-daptomycin-in-outpatient-parenteral-antimicrobial-therapy-a-prospective-and-multicenter-cohort-study-daptodom-trial
#13
MULTICENTER STUDY
Carlos Cervera, Pedro Sanroma, Víctor González-Ramallo, Cristina García de la María, Gemma Sanclemente, Nieves Sopena, Marcos Pajarón, Antonio Segado, Manuel Mirón, Francisco Antón, Andima Basterretxea, Ana Cuende, José M Miró
BACKGROUND: Daptomycin is an optimal choice for outpatient parenteral antibiotic therapy (OPAT) because of its safety, once-daily administration and its activity against Gram-positive bacteria. Although daptomycin is increasingly being used in OPAT, limited information about its safety in this scenario is available. METHODS: We performed a prospective multicentre pilot study to evaluate the safety of daptomycin in outpatients with proved or suspected Gram-positive infections (DAPTODOM)...
March 2017: Infectious Diseases
https://www.readbyqxmd.com/read/27807591/value-and-clinical-impact-of-an-infectious-disease-supervised-outpatient-parenteral-antibiotic-therapy-program
#14
Russell M Petrak, Nathan C Skorodin, Robert M Fliegelman, David W Hines, Vishnu V Chundi, Brian P Harting
Background.  Outpatient parenteral antibiotic therapy (OPAT) is a safe and effective modality for treating serious infections. This study was undertaken to define the value of OPAT in a multicentered infectious disease (ID) private practice setting. Methods.  Over a period of 32 months, 6120 patients were treated using 19 outpatient ID offices in 6 states. Analysis included patient demographics, indications of OPAT, diagnoses, therapeutic agent, duration of therapy, and site of therapy initiation. Outcomes were stratified by therapeutic success, clinical relapse, therapeutic complications, and hospitalizations after initiating therapy...
October 2016: Open Forum Infectious Diseases
https://www.readbyqxmd.com/read/27801359/bed-utilisation-in-an-irish-regional-paediatric-unit-a-cross-sectional-study-using-the-paediatric-appropriateness-evaluation-protocol-paep
#15
Coilín ÓhAiseadha, Mai Mannix, Jean Saunders, Roy K Philip
BACKGROUND: Increasing demand for limited healthcare resources raises questions about appropriate use of inpatient beds. In the first paediatric bed utilisation study at a regional university centre in Ireland, we conducted a cross-sectional study to audit the utilisation of inpatient beds at the Regional Paediatric Unit (RPU) in University Hospital Limerick (UHL), Limerick, Ireland and also examined hospital activity data, to make recommendations for optimal use of inpatient resources...
May 10, 2016: International Journal of Health Policy and Management
https://www.readbyqxmd.com/read/27792443/optimising-patient-safety-when-using-elastomeric-pumps-to-administer-outpatient-parenteral-antibiotic-therapy
#16
Gemma Oliver
Outpatient parenteral antibiotic therapy (OPAT) is a growing area of practice that has numerous benefits for both patients and the healthcare system. In order for OPAT services to be successful, strategies need to be in place to maximise efficiency while providing safe, high-quality care. The use of elastomeric pumps to deliver intravenous (IV) antibiotics can have many benefits for OPAT services; they are cost-effective, easy to use and allow the patient to be fully ambulant. However, plans need to be put in place to make sure their use is safe and effective...
October 27, 2016: British Journal of Nursing: BJN
https://www.readbyqxmd.com/read/27747899/safety-and-efficacy-of-outpatient-parenteral-antibiotic-therapy-in-an-academic-infectious-disease-clinic
#17
G Suleyman, R Kenney, M J Zervos, A Weinmann
WHAT IS KNOWN AND OBJECTIVE: Outpatient parenteral therapy (OPAT) has become a safe and effective modality for patients requiring intravenous or prolonged antimicrobial therapy since the 1970s. It is being increasingly utilized in various settings; however, studies evaluating the safety and efficacy of clinic-based OPAT are limited. Since 2012, patients being considered for OPAT have required an infectious disease (ID) consultation at our institution. Candidates receiving once-daily antimicrobials who were ineligible for home infusion or nursing home placement as determined by their insurance companies and those who preferred the clinic over nursing home or home infusion were referred to the ID clinic...
February 2017: Journal of Clinical Pharmacy and Therapeutics
https://www.readbyqxmd.com/read/27553996/guidelines-for-timely-initiation-of-chemotherapy-a-proposed-framework-for-access-to-medical-oncology-and-haematology-cancer-clinics-and-chemotherapy-services
#18
M Alexander, R Beattie-Manning, R Blum, J Byrne, C Hornby, C Kearny, N Love, J McGlashan, S McKiernan, J L Milar, D Murray, S Opat, P Parente, J Thomas, N Tweddle, C Underhill, K Whitfield, S Kirsa, D Rischin
These guidelines, informed by the best available evidence and consensus expert opinion, provide a framework to guide the timely initiation of chemotherapy for treating cancer. They sit at the intersection of patient experience, state-of-the-art disease management and rational efficient service provision for these patients at a system level. Internationally, cancer waiting times are routinely measured and publicly reported. In Australia, there are existing policies and guidelines relating to the timeliness of cancer care for surgery and radiation therapy; however, until now, equivalent guidance for chemotherapy was lacking...
August 2016: Internal Medicine Journal
https://www.readbyqxmd.com/read/27540212/what-is-the-maximum-temperature-reached-in-elastomeric-devices-under-simulated-opat-conditions
#19
Susanna van Der Merwe, Helen Green
AIM: Outpatient parenteral antimicrobial therapy (OPAT), both in children and adults, is increasing in use as part of a cost saving measure for the NHS.1 However there is a general lack of stability data for antibiotics in elastomeric devices. The 'Yellow Covered Document'2 (YCD), as it is commonly known, specifies the storage conditions, under which stability testing should be carried out ranging from freezing to a worst case scenario of 37°C±2°C. It is assumed that a temperature of 37°C equates to wearing a device reservoir under clothing close to the body e...
September 2016: Archives of Disease in Childhood
https://www.readbyqxmd.com/read/27396268/timely-initiation-of-chemotherapy-a-systematic-literature-review-of-six-priority-cancers-results-and-recommendations-for-clinical-practice
#20
REVIEW
M Alexander, R Blum, K Burbury, J Coutsouvelis, M Dooley, O Fazil, T Griffiths, H Ismail, S Joshi, N Love, S Opat, P Parente, N Porter, E Ross, J Siderov, P Thomas, S White, S Kirsa, D Rischin
This review evaluated the association between time-to-chemotherapy (TTC) and survival in six priority cancers. A systematic review of the literature was undertaken for papers indexed in the MEDLINE and Cochrane Library databases from the earliest index until April 2014. The methodology used has been published in a separate paper (Guidelines for timely initiation of chemotherapy: a proposed framework for access to medical oncology and haematology cancer clinics and chemotherapy services). The optimal timing of chemotherapy in breast cancer is unclear as available studies are of low quality, report inconsistent results and are limited to the adjuvant setting...
January 2017: Internal Medicine Journal
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