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https://www.readbyqxmd.com/read/29412536/introducing-outpatient-parenteral-antimicrobial-therapy-in-a-children-s-hospital
#1
Sally Bolsover
Outpatient parenteral antimicrobial therapy (OPAT) offers an alternative to inpatient care for delivering intravenous antibiotics in patients' homes or in a day care clinic setting. It was first introduced in North America in the 1970s and has evolved over the years, starting with the adult population and now moving to the paediatric population ( Chapman 2013 ). OPAT has the potential to offer excellent, patient-centred, high-quality care to treat a wide variety of infectious conditions in patients who are medically stable and do not need hospitalisation...
February 7, 2018: Nursing Children and Young People
https://www.readbyqxmd.com/read/29385901/opat-proof-of-concept-in-a-peripheral-belgian-hospital-after-review-of-the-literature
#2
Annick Smismans, Astrid Vantrappen, Freija Verbiest, Christophe Indevuyst, Bea Van den Poel, Sandrina von Winckelmann, Annelore Peeters, Sara Ombelet, Peter Lybeert, Andre Heremans, Eric Frans, Erwin Ho, Johan Frans
Since its introduction in the 1970s in the United States, outpatient parenteral antibiotic/antimicrobial therapy (OPAT) has been adopted internationally for long-term intravenous (IV) treatment of stable infectious diseases. The aim is to provide a safe and successful completion of IV antimicrobial treatment at the ambulatory care center or at home without complications and costs associated with hospitalization. OPAT implementation has been accelerated by progress in vascular access devices, newly available antibiotics, the emphasis on cost-savings, as well as an improved patient comfort and a reduced incidence of health care associated infections with a similar outcome...
January 31, 2018: Acta Clinica Belgica
https://www.readbyqxmd.com/read/29326190/a-qualitative-study-of-patients-feedback-about-outpatient-parenteral-antimicrobial-therapy-opat-services-in-northern-england-implications-for-service-improvement
#3
Maureen Twiddy, Carolyn J Czoski Murray, Samantha J Mason, David Meads, Judy M Wright, Elizabeth D Mitchell, Jane Minton
OBJECTIVE: Outpatient parenteral antimicrobial therapy (OPAT) provides opportunities for improved cost savings, but in the UK, implementation is patchy and a variety of service models are in use. The slow uptake in the UK and Europe is due to a number of clinical, financial and logistical issues, including concern about patient safety. The measurement of patient experience data is commonly used to inform commissioning decisions, but these focus on functional aspects of services and fail to examine the relational aspects of care...
January 10, 2018: BMJ Open
https://www.readbyqxmd.com/read/29318305/geographical-origin-characterization-of-slovenian-organic-garlic-using-stable-isotope-and-elemental-composition-analyses
#4
Anja Mahne Opatić, Marijan Nečemer, David Kocman, Sonja Lojen
In the present research, the applicability of stable isotope (δ13C, δ15N, δ34S, δ18O) and multi-element (P, S, Cl, K, Ca, Zn, Br, Rb, Sr) data for determining the geographical origin of garlic (Allium sativum L.) at the scale of Slovenia was examined. Slovenia is a rather small country (20273 km2) with significant geological and biological diversity. Garlic, valued for its medicinal properties, was collected from Slovenian farms with certified organic production and analyzed by elemental analyzer isotope ratio mass spectrometry combined with energy dispersive X- ray fluorescence spectrometry...
December 2017: Acta Chimica Slovenica
https://www.readbyqxmd.com/read/29233820/adaptive-reprogramming-of-nk-cells-in-x-linked-lymphoproliferative-syndrome
#5
Stephen Opat, Anna Hearps, Kevin Thia, Agnes Yuen, Ben Rogers, Mkunde Chachage, Gregory Moore, Jake Shortt, Georgina Ryland, Piers Blombery, Anthony P Schwarer, Tahereh Noori, Joseph A Trapani, Anthony Jaworowski, Ilia Voskoboinik
No abstract text is available yet for this article.
December 12, 2017: Blood
https://www.readbyqxmd.com/read/29099632/chemoimmunotherapy-may-not-be-dead-yet-in-chronic-lymphocytic-leukemia-but-fludarabine-plus-cyclophosphamide-plus-rituximab-is-potentially-facing-life-support
#6
Stephen Opat, Eliza A Hawkes
No abstract text is available yet for this article.
November 3, 2017: Journal of Clinical Oncology: Official Journal of the American Society of Clinical Oncology
https://www.readbyqxmd.com/read/29099631/reply-to-s-opat-et-al
#7
Jennifer R Brown, Neil E Kay
No abstract text is available yet for this article.
November 3, 2017: Journal of Clinical Oncology: Official Journal of the American Society of Clinical Oncology
https://www.readbyqxmd.com/read/29091189/successful-outpatient-parenteral-antibiotic-therapy-delivery-via-telemedicine
#8
Shu J Tan, Paul R Ingram, Alison J Rothnie, Timothy J Whitmore, James O Robinson, Jillian B Hatch, Claire M Italiano, Christopher H Heath
Objectives: Most outpatient parenteral antimicrobial therapy (OPAT) services use a hospital-based model of care in which patients remain in proximity to large hospitals facilitating clinical review. We aimed to evaluate clinical outcomes and complication rates for patients living in geographically isolated locations managed by telemedicine-supported OPAT. Methods: This was a retrospective cohort study. Results: Between 2011 and 2015, we delivered 88 episodes of care involving 83 adult patients resulting in 2261 days of OPAT...
October 1, 2017: Journal of Antimicrobial Chemotherapy
https://www.readbyqxmd.com/read/29090606/efficiency-of-a-self-administered-outpatient-parenteral-antimicrobial-therapy-s-opat-for-infective-endocarditis-within-the-context-of-a-shortened-hospital-admission-based-on-hospital-at-home-program
#9
Marcos Pajarón, Marta Lisa, Manuel F Fernández-Miera, Juan C Dueñas, I Allende, Ana M Arnaiz, Pedro Sanroma-Mendizábal, José R De Berrazueta, María C Fariñas
OBJECTIVE: This study aimed to evaluate the efficiency of treatment of infectious endocarditis (IE) via Self-administered Outpatient Parenteral Antimicrobial Therapy (S-OPAT) supported by a shortening hospital admission program in a hospitalization-at-home unit (HAH), including a short review of the literature. METHODS: Ambispective cohort study of 57 episodes of IE in 54 patients treated in an HAH unit between 1988 and 2014 who receive S-OPAT after prior intra-hospital clinical stabilization...
December 2017: Hospital Practice (Minneapolis)
https://www.readbyqxmd.com/read/29050864/outpatient-parenteral-antibiotic-therapy-evaluation-of-practices-and-limits-of-use-in-rural-areas-in-france
#10
C Triffault-Fillit, T Ferry, T Perpoint, L Adélaïde, S Le Ngoc Tho, F Ader, C Chidiac, F Valour
OBJECTIVES: To evaluate outpatient parenteral antibiotic therapy (OPAT) practices in a French rural area. MATERIAL AND METHODS: Descriptive study assessing knowledge, practices, and limitations of OPAT use among hospital practitioners (HP), family physicians (FP), and private nurses (PN). RESULTS: OPAT (mainly ceftriaxone and penicillins) was used by 69.6%, 73.3%, and 97.7% of the 23 HPs, 45 FPs, and 46 PNs mostly for respiratory or urinary tract infections, bacteremia, and/or multidrug-resistant bacterial infections...
October 16, 2017: Médecine et Maladies Infectieuses
https://www.readbyqxmd.com/read/29020202/rates-of-and-risk-factors-for-adverse-drug-events-in-outpatient-parenteral-antimicrobial-therapy
#11
Sara C Keller, Deborah Williams, Mitra Gavgani, David Hirsch, John Adamovich, Dawn Hohl, Ayse P Gurses, Sara E Cosgrove
Background: To better monitor patients on outpatient parenteral antimicrobial therapy (OPAT), we need an improved understanding of risk factors for and timing of OPAT-associated adverse drug events (ADEs). Methods: We undertook an analysis of a prospective cohort of patients discharged from two academic medical centers on OPAT. Patients underwent chart abstraction and a telephone survey. Multivariable analyses estimated adjusted incident rate ratios (aIRR) between clinical and demographic risk factors and clinician-determined clinically significant ADEs...
August 17, 2017: Clinical Infectious Diseases: An Official Publication of the Infectious Diseases Society of America
https://www.readbyqxmd.com/read/28981573/opats-omnibus-p-value-association-tests
#12
Chia-Wei Chen, Hsin-Chou Yang
Combining statistical significances (P-values) from a set of single-locus association tests in genome-wide association studies is a proof-of-principle method for identifying disease-associated genomic segments, functional genes and biological pathways. We review P-value combinations for genome-wide association studies and introduce an integrated analysis tool, Omnibus P-value Association Tests (OPATs), which provides popular analysis methods of P-value combinations. The software OPATs programmed in R and R graphical user interface features a user-friendly interface...
July 10, 2017: Briefings in Bioinformatics
https://www.readbyqxmd.com/read/28976863/obinutuzumab-for-the-first-line-treatment-of-follicular-lymphoma
#13
RANDOMIZED CONTROLLED TRIAL
Robert Marcus, Andrew Davies, Kiyoshi Ando, Wolfram Klapper, Stephen Opat, Carolyn Owen, Elizabeth Phillips, Randeep Sangha, Rudolf Schlag, John F Seymour, William Townsend, Marek Trněný, Michael Wenger, Günter Fingerle-Rowson, Kaspar Rufibach, Tom Moore, Michael Herold, Wolfgang Hiddemann
BACKGROUND: Rituximab-based immunochemotherapy has improved outcomes in patients with follicular lymphoma. Obinutuzumab is a glycoengineered type II anti-CD20 monoclonal antibody. We compared rituximab-based chemotherapy with obinutuzumab-based chemotherapy in patients with previously untreated advanced-stage follicular lymphoma. METHODS: We randomly assigned patients to undergo induction treatment with obinutuzumab-based chemotherapy or rituximab-based chemotherapy...
October 5, 2017: New England Journal of Medicine
https://www.readbyqxmd.com/read/28949430/effectiveness-and-safety-of-outpatient-parenteral-antimicrobial-therapy-in-acute-exacerbation-of-chronic-obstructive-pulmonary-disease
#14
Miguel A Ponce González, Manuel Mirón Rubio, Abel Mujal Martinez, Oriol Estrada Cuxart, Dolores Fiuza Perez, Liliana Salas Reinoso, Estrella Fernández Fabrellas, Eusebi Chiner Vives
AIM: We analysed the effectiveness and safety of outpatient parenteral antibiotic therapy (OPAT) in acute exacerbation of chronic obstructive pulmonary disease (AECOPD) in patients admitted to home hospitalisation units (HHU). METHODS: Retrospective multicentre study of patients with AECOPD included in the Spanish OPAT Registry during 2 years period. RESULTS: Twenty-seven hospitals included 562 episodes in 361 patients diagnosed COPD GOLD III-IV...
September 26, 2017: International Journal of Clinical Practice
https://www.readbyqxmd.com/read/28885476/determining-the-risk-of-sepsis-using-nurse-compounded-elastomeric-pumps-for-continuous-infusion-in-outpatient-parenteral-antibiotic-therapy
#15
Pauline M Dobson, Mark Loewenthal, Lisa Harris
Limited availability of compounded antibiotics used for continuous infusion outpatient parenteral antibiotic therapy (OPAT) can delay or interrupt an OPAT course. To solve this problem, OPAT nurses at a hospital in Australia have been compounding elastomeric pumps for immediate use. The incidence of sepsis in 5014 patients before and after the introduction of nurse compounding was compared. There were no cases of laboratory-confirmed bloodstream infection among the nurse-compounded group compared with 2 cases (0...
September 2017: Journal of Infusion Nursing: the Official Publication of the Infusion Nurses Society
https://www.readbyqxmd.com/read/28874503/risk-factors-for-amendment-in-type-duration-and-setting-of-prescribed-outpatient-parenteral-antimicrobial-therapy-opat-for-adult-patients-with-cellulitis-a-retrospective-cohort-study-and-cart-analysis
#16
Michael Quirke, Emma May Curran, Patrick O'Kelly, Ruth Moran, Eimear Daly, Seamus Aylward, Gerry McElvaney, Abel Wakai
PURPOSE OF THE STUDY: To measure the percentage rate and risk factors for amendment in the type, duration and setting of outpatient parenteral antimicrobial therapy (OPAT) for the treatment of cellulitis. STUDY DESIGN: A retrospective cohort study of adult patients receiving OPAT for cellulitis was performed. Treatment amendment (TA) was defined as hospital admission or change in antibiotic therapy in order to achieve clinical response. Multivariable logistic regression (MVLR) and classification and regression tree (CART) analysis were performed...
September 5, 2017: Postgraduate Medical Journal
https://www.readbyqxmd.com/read/28852672/bundle-in-the-bronx-impact-of-a-transition-of-care-outpatient-parenteral-antibiotic-therapy-bundle-on-all-cause-30-day-hospital-readmissions
#17
Theresa Madaline, Priya Nori, Wenzhu Mowrey, Elisabeth Zukowski, Shruti Gohil, Uzma Sarwar, Gregory Weston, Riganni Urrely, Matthew Palombelli, Vinnie Frank Pierino, Vanessa Parsons, Amy Ehrlich, Belinda Ostrowsky, Marilou Corpuz, Liise-Anne Pirofski
BACKGROUND: A streamlined transition from inpatient to outpatient care can decrease 30-day readmissions. Outpatient parenteral antibiotic therapy (OPAT) programs have not reduced readmissions; an OPAT bundle has been suggested to improve outcomes. We implemented a transition-of-care (TOC) OPAT bundle and assessed the effects on all-cause, 30-day hospital readmission. METHODS: Retrospectively, patients receiving postdischarge intravenous antibiotics were evaluated before and after implementation of a TOC-OPAT program in Bronx, New York, between July, 2015 and February, 2016...
2017: Open Forum Infectious Diseases
https://www.readbyqxmd.com/read/28776441/economic-evaluation-of-outpatient-parenteral-antimicrobial-therapy-a-systematic-review
#18
REVIEW
Eliane Molina Psaltikidis, Everton Nunes da Silva, Joaquim Murray Bustorff-Silva, Maria Luiza Moretti, Mariângela Ribeiro Resende
Outpatient parenteral antimicrobial therapy (OPAT) consists of providing antimicrobial therapy by parenteral infusion without hospitalization. A systematic review was performed to compare OPAT and hospitalization as health care modalities from an economic perspective. Areas covered: We identified 1455 articles using 13 electronic databases and manual searches. Two independent reviewers identified 35 studies conducted between 1978 and 2016. We observed high heterogeneity in the following: countries, infection site, OPAT strategies and outcomes analyzed...
August 2017: Expert Review of Pharmacoeconomics & Outcomes Research
https://www.readbyqxmd.com/read/28763427/safety-of-outpatient-parenteral-antimicrobial-therapy-in-children
#19
Priyanka Fernandes, Carly Milliren, Helen M Mahoney-West, Laura Schwartz, Catherine S Lachenauer, Mari M Nakamura
BACKGROUND AND OBJECTIVE: Outpatient parenteral antimicrobial therapy (OPAT) provides numerous benefits but may pose unique risks in children. We aimed to determine rates of OPAT antimicrobial- and intravenous-access-related complications and their associations with specific antimicrobials and type of intravenous access in pediatric patients. METHODS: Observational cohort study of patients receiving OPAT from 8/2008 to 5/2015 cared for by the Infectious Diseases service at a tertiary children's hospital...
July 31, 2017: Pediatric Infectious Disease Journal
https://www.readbyqxmd.com/read/28711455/recommendations-for-outpatient-parenteral-antimicrobial-therapy-in-brazil
#20
REVIEW
Priscila R Oliveira, Vladimir C Carvalho, Sergio Cimerman, Ana Lucia Munhoz Lima
A panel of national experts was convened by the Brazilian Infectious Diseases Society in order to determine the recommendations for outpatient parenteral antimicrobial therapy (OPAT) in Brazil. The following aspects are covered in the document: organization of OPAT programs; patient evaluation and eligibility criteria, including clinical and sociocultural factors; diagnosis of eligibility; venous access and antimicrobial infusion devices; protocols for antimicrobial use and monitoring and cost-effectiveness...
November 2017: Brazilian Journal of Infectious Diseases
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