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Lactobacillus gasseri

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https://www.readbyqxmd.com/read/28631049/novel-probiotics-isolated-from-a-japanese-traditional-fermented-food-funazushi-attenuates-dss-induced-colitis-by-increasing-the-induction-of-high-integrin-%C3%AE-v-%C3%AE-8-expressing-dendritic-cells
#1
Yoshikiyo Okada, Yoshikazu Tsuzuki, Takajo Takeshi, Hirotaka Furuhashi, Masaaki Higashiyama, Chikako Watanabe, Kazuhiko Shirakabe, Chie Kurihara, Shunsuke Komoto, Kengo Tomita, Shigeaki Nagao, Soichiro Miura, Ryota Hokari
BACKGROUND: We isolated two novel probiotics strains (s193 and s292) from Funazushi, which is a traditional Japanese fermented food, and evaluated its effects on DSS-induced colitis to determine the possible underlying mechanisms. METHODS: A single colony from homogenized Funazushi was isolated by its ability to suppress TNF-α in RAW 264.7. Effect of probiotics on colonic inflammation induced by DSS was evaluated. Effect of probiotics on Treg induction by CD11c(+) dendritic cells (DCs) of MLNs were analyzed...
June 19, 2017: Journal of Gastroenterology
https://www.readbyqxmd.com/read/28620369/characterization-of-bile-salt-hydrolase-from-lactobacillus-gasseri-fr4-and-demonstration-of-its-substrate-specificity-and-inhibitory-mechanism-using-molecular-docking-analysis
#2
Rizwana Parveen Rani, Marimuthu Anandharaj, Abraham David Ravindran
Probiotic bacteria are beneficial to the health of poultry animals, thus are used as alternative candidates for antibiotics used as growth promoters (AGPs). However, they also reduce the body weight gain due to innate bile salt hydrolase (BSH) activity. Hence, the addition of a suitable BSH inhibitor along with the probiotic feed can decrease the BSH activity. In this study, a BSH gene (981 bp) encoding 326-amino acids was identified from the genome of Lactobacillus gasseri FR4 (LgBSH). The LgBSH-encoding gene was cloned and purified using an Escherichia coli BL21 (DE3) expression system, and its molecular weight (37 kDa) was confirmed by SDS-PAGE and a Western blot analysis...
2017: Frontiers in Microbiology
https://www.readbyqxmd.com/read/28618863/interaction-of-vaginal-lactobacillus-strains-with-hela-cells-plasma-membrane
#3
N Calonghi, C Parolin, G Sartor, L Verardi, B Giordani, G Frisco, A Marangoni, B Vitali
Vaginal lactobacilli offer protection against recurrent urinary and vaginal infections. The precise mechanisms underlying the interaction between lactobacilli and the host epithelium remain poorly understood at the molecular level. Deciphering such events can provide valuable information on the mode of action of commensal and probiotic bacteria in the vaginal environment. We investigated the effects exerted by five Lactobacillus strains of vaginal origin (Lactobacillus crispatus BC1 and BC2, Lactobacillus gasseri BC9 and BC11 and Lactobacillus vaginalis BC15) on the physical properties of the plasma membrane in a cervical cell line (HeLa)...
June 16, 2017: Beneficial Microbes
https://www.readbyqxmd.com/read/28618860/the-effects-of-the-lactobacillus-casei-strain-on-obesity-in-children-a-pilot-study
#4
S Nagata, Y Chiba, C Wang, Y Yamashiro
There are few data regarding the role of probiotics as a dietary intervention in the management of obesity in children. An open prospective examination was conducted to clarify the effects of Lactobacillus casei strain Shirota (LcS)-containing beverages in obese children. We compared the intestinal microbiota and organic acid levels between 12 obese (average age, 10.8 years; body mass index (BMI) Z score, 2.7±1.7) and 22 control children(average age, 8.5 years; BMI Z score, 0.1±0.7), and pre- and post-intervention in the obese children...
June 16, 2017: Beneficial Microbes
https://www.readbyqxmd.com/read/28574626/assessment-of-phenotypic-and-genotypic-antibiotic-susceptibility-of-vaginal-lactobacillus-sp
#5
Jelena Štšepetova, Heleri Taelma, Imbi Smidt, Pirje Hütt, Eleri Lapp, Evi Aotäht, Reet Mändar
AIM: To assess antibiotic susceptibility of vaginal lactobacilli strains and provide the data required for assessing the potential of antibiotic resistance risk of new strains selected as probiotic. METHODS AND RESULTS: Potential probiotic vaginal lactobacilli used in the study included 31 vaginal strains of Lactobacillus crispatus, (n=27), L. gasseri (n=3) and L. jensenii (n=1) obtained from the collection of Competence Centre on Health Technologies. Two commercial probiotic strains were used as controls (L...
June 2, 2017: Journal of Applied Microbiology
https://www.readbyqxmd.com/read/28554813/impact-of-exopolysaccharides-epss-of-lactobacillus-gasseri-strains-isolated-from-human-vagina-on-cervical-tumor-cells-hela
#6
Tolga Sungur, Belma Aslim, Cagtay Karaaslan, Busra Aktas
Lactobacilli, commonly used as probiotics, have been shown to maintain vaginal health and contribute to host microbiota interaction. Exopolysaccharides (EPSs) produced by lactobacillus have been found to have an important role in probiotic activity; however, there is limited knowledge concerning their impact on cervical cancer and urogenital health. The objective of this study is to investigate and compare EPSs of L. gasseri strains (G10 and H15), isolated from a healthy human vagina, for their capability to inhibit cervical cancer cell (HeLa) growth and modulate immune response...
May 26, 2017: Anaerobe
https://www.readbyqxmd.com/read/28553274/association-between-yogurt-consumption-and-intestinal-microbiota-in-healthy-young-adults-differs-by-host-gender
#7
Yoshio Suzuki, Keiichi Ikeda, Kazuhiko Sakuma, Sachio Kawai, Keisuke Sawaki, Takashi Asahara, Takuya Takahashi, Hirokazu Tsuji, Koji Nomoto, Ravinder Nagpal, Chongxin Wang, Satoru Nagata, Yuichiro Yamashiro
Human intestinal microbiota are influenced by various factors viz. diet, environment, age, gender, geographical, and socioeconomic situation, etc. among which diet has the most profound impact. However, studies investigating this impact have mostly included subjects from diverse geographic/socioeconomic backgrounds and hence the precise effects of dietary factors on gut microbiota composition remain largely confounded. Herein, with an aim to evaluate the association between dietary habits, specifically yogurt consumption, and the gut microbiota in healthy young adults sharing similar age, lifestyle routine, geographical setting, etc...
2017: Frontiers in Microbiology
https://www.readbyqxmd.com/read/28522362/susceptibility-of-bacterial-vaginosis-bv-associated-bacteria-to-secnidazole-compared-to-metronidazole-tinidazole-and-clindamycin
#8
Melinda A B Petrina, Lisa A Cosentino, Lorna K Rabe, Sharon L Hillier
Secnidazole, a 5-nitroimidazole with a longer half-life, is structurally related to metronidazole and tinidazole. For treatment of bacterial vaginosis (BV), secnidazole is a suitable single-dose oral drug having a longer serum half-life than metronidazole. The objective of this study was to evaluate the antimicrobial susceptibility of vaginal isolates of facultative and anaerobic bacteria to secnidazole, metronidazole, tinidazole and clindamycin. A total of 605 unique BV-related bacteria and 108 isolates of lactobacilli recovered from the human vagina of US women during the years 2009-2015 were tested for antimicrobial susceptibility by the agar dilution CLSI reference method to determine the minimal inhibitory concentration (MIC)...
May 15, 2017: Anaerobe
https://www.readbyqxmd.com/read/28508168/distinct-histone-modifications-modulate-defb1-expression-in-human-vaginal-keratinocytes-in-response-to-lactobacillus-spp
#9
Jaehyouk Lee, Ara Jang, Jin Wook Kim, Jun Hyun Han, Byung Hee Chun, Hye Su Jung, Che Ok Jeon, Soon Chul Myung
Vaginal commensal lactobacilli are considered to contribute significantly to the control of vaginal microbiota by competing with other microflora for adherence to the vaginal epithelium and by producing antimicrobial compounds. However, the molecular mechanisms of symbiotic prokaryotic-eukaryotic communication in the vaginal ecosystem remain poorly understood. Here, we showed that both DNA methylation and histone modifications were associated with expression of the DEFB1 gene, which encodes the antimicrobial peptide human β-defensin-1, in vaginal keratinocyte VK2/E6E7 cells...
May 15, 2017: Probiotics and Antimicrobial Proteins
https://www.readbyqxmd.com/read/28493927/protective-effects-and-functional-mechanisms-of-lactobacillus-gasseri-sbt2055-against-oxidative-stress
#10
Eiji Kobatake, Hisako Nakagawa, Takahiro Seki, Tadaaki Miyazaki
Lactobacillus gasseri SBT2055 (LG2055) is one of the probiotic lactic acid bacteria. Recently, we demonstrated that feeding with LG2055 extended the lifespan of Caenorhabditis elegans and that the prolongevity effect was dependent upon the regulation of oxidative stress response. In this study, we assessed whether LG2055 regulated the oxidative stress response of mammalian cells. In NIH-3T3 cells and primary mouse embryonic fibroblast cells, low cell proliferation rates and high reactive oxygen species levels were observed following paraquat treatment...
2017: PloS One
https://www.readbyqxmd.com/read/28474851/antioxidant-activity-of-various-oral-lactobacillus-strains
#11
A Chooruk, S Piwat, R Teanpaisan
AIMS: This study aims to evaluate the antioxidant activity of oral Lactobacillus strains in vitro. METHODS AND RESULTS: A total of 201 Lactobacillus strains were investigated for antioxidant activities: free radical scavenging (DPPH), inhibition of linoleic acid peroxidation (TAALA ), superoxide dismutase (SOD) and glutathione (GSH). Resistance to reactive oxygen species was also assessed. Results showed that there was a wide range of individual antioxidant properties of DPPH, TAALA , SOD and GSH between/within the species of Lactobacillus strains...
May 5, 2017: Journal of Applied Microbiology
https://www.readbyqxmd.com/read/28473372/draft-genome-sequences-of-the-aerobic-strains-lactobacillus-gasseri-al3-and-al5
#12
Diamante Maresca, Francesca De Filippis, Hanne L P Tytgat, Willem M de Vos, Gianluigi Mauriello
Adaptation to the aerobic environment has been investigated in heterofermentative lactobacilli, while data on how homofermentative lactobacilli adapt to oxygen are limited. We report here the draft genome sequences of the aerobic strains Lactobacillus gasseri AL3 and AL5 that allow an in-depth investigation of the genes involved in oxidative metabolism and the stress response.
May 4, 2017: Genome Announcements
https://www.readbyqxmd.com/read/28421058/antimicrobial-compounds-produced-by-vaginal-lactobacillus-crispatus-are-able-to-strongly-inhibit-candida-albicans-growth-hyphal-formation-and-regulate-virulence-related-gene-expressions
#13
Shuai Wang, Qiangyi Wang, Ence Yang, Ling Yan, Tong Li, Hui Zhuang
The female vaginal environment contains diverse microorganisms, and their interactions play significant roles in health and disease. Lactobacillus species are the predominant vaginal microorganisms in healthy women and relevant as a barrier to defense against pathogens, including Candida albicans. The yeast-to-hyphae transition is believed to be a determinant of C. albicans pathogenesis. In this study, we investigated the effects of vaginal isolates of L. crispatus (seven strains), L. gasseri (six strains), and L...
2017: Frontiers in Microbiology
https://www.readbyqxmd.com/read/28374172/evaluation-of-potential-probiotics-isolated-from-human-milk-and-colostrum
#14
Quésia S Damaceno, Jaqueline P Souza, Jacques R Nicoli, Raquel L Paula, Gabriela B Assis, Henrique C Figueiredo, Vasco Azevedo, Flaviano S Martins
Several studies have demonstrated a diversity of bacterial species in human milk, even in aseptically collected samples. The present study evaluated potential probiotic bacteria isolated from human milk and associated maternal variables. Milk samples were collected from 47 healthy women and cultured on selective and universal agar media under aerobic and anaerobic conditions. Bacterial isolates were counted and identified by Biotyper Matrix-Assisted Laser Desorption Ionization-Time of Flight mass spectrometry and then tested for probiotic properties...
April 3, 2017: Probiotics and Antimicrobial Proteins
https://www.readbyqxmd.com/read/28373699/oral-administration-of-lactobacillus-gasseri-sbt2055-is-effective-in-preventing-porphyromonas-gingivalis-accelerated-periodontal-disease
#15
R Kobayashi, T Kobayashi, F Sakai, T Hosoya, M Yamamoto, T Kurita-Ochiai
Probiotics have been used to treat gastrointestinal disorders. However, the effect of orally intubated probiotics on oral disease remains unclear. We assessed the potential of oral administration of Lactobacillus gasseri SBT2055 (LG2055) for Porphyromonas gingivalis infection. LG2055 treatment significantly reduced alveolar bone loss, detachment and disorganization of the periodontal ligament, and bacterial colonization by subsequent P. gingivalis challenge. Furthermore, the expression and secretion of TNF-α and IL-6 in gingival tissue was significantly decreased in LG2055-administered mice after bacterial infection...
April 3, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28366852/protective-effect-of-surface-layer-proteins-isolated-from-four-lactobacillus-strains-on-hydrogen-peroxide-induced-ht-29-cells-oxidative-stress
#16
Bin-Bin Zhao, Jun Meng, Qiu-Xiang Zhang, Ting-Ting Kang, Rong-Rong Lu
The objective of this study was to explore the antioxidant effect of the surface layer proteins (SLPs) and their mechanism. We investigated four SLPs which were extracted from L. casei zhang, L. rhamnosus, L. gasseri and L. acidophilus NCFM respectively using LiCl. The protective effect of SLPs on H2O2-induced HT-29 cells oxidative injury was investigated. As results, SLPs (100μg/mL) could significantly mitigate HT-29 cells cytotoxicity, improve the activities of total antioxidant capacity (T-AOC), catalase (CAT) and superoxide dismutase (SOD), decrease the contents of malondialdehyde (MDA) and lactate dehydrogenase (LDH), compared with H2O2-induced group (P<0...
March 30, 2017: International Journal of Biological Macromolecules
https://www.readbyqxmd.com/read/28315382/characterization-of-vaginal-lactobacillus-species-by-rplk-based-multiplex-qpcr-in-russian-women
#17
Vladimir V Demkin, Stanislav I Koshechkin
We describe a multiplex qPCR assay for identification and quantitative assessment of a set of vaginal Lactobacillus species, including L. acidophilus, L. crispatus, L. gasseri, L. helveticus, L. iners, and L. jensenii. The assay extends the previously developed qPCR method for Lactobacillus detection and total quantification based on targeting the rplK gene. Both assays use only single pair of primers and a set of probes combined in three reactions, comprising a vaginal Lactobacillus diagnostic assay panel...
March 14, 2017: Anaerobe
https://www.readbyqxmd.com/read/28282902/lactobacillus-gasseri-pa-3-uses-the-purines-imp-inosine-and-hypoxanthine-and-reduces-their-absorption-in-rats
#18
Naruomi Yamada, Chizuru Saito-Iwamoto, Marie Nakamura, Misato Soeda, Yoshika Chiba, Hiroshi Kano, Yukio Asami
Excessive intake of purine-rich foods elevates serum levels of uric acid. Animal and fish meats contain high amounts of inosine and its related purines, and the reduction of taking those purines is crucial for the improvement of serum uric acid levels. We previously showed that Lactobacillus gasseri PA-3 (PA-3) incorporates adenosine and its related purines and that oral treatment with PA-3 reduced adenosine absorption in rats. This study investigated whether PA-3 also incorporates IMP (inosine 5'-monophosphate), inosine, and hypoxanthine, and whether it reduces their absorption in rats...
March 8, 2017: Microorganisms
https://www.readbyqxmd.com/read/28228426/probiotics-lactobacillus-gasseri-ks-13-bifidobacterium-bifidum-g9-1-and-bifidobacterium-longum-mm-2-improve-rhinoconjunctivitis-specific-quality-of-life-in-individuals-with-seasonal-allergies-a-double-blind-placebo-controlled-randomized-trial
#19
RANDOMIZED CONTROLLED TRIAL
Jennifer C Dennis-Wall, Tyler Culpepper, Carmelo Nieves, Cassie C Rowe, Alyssa M Burns, Carley T Rusch, Ashton Federico, Maria Ukhanova, Sheldon Waugh, Volker Mai, Mary C Christman, Bobbi Langkamp-Henken
Background: Rhinoconjunctivitis-specific quality of life is often reduced during seasonal allergies. The Mini Rhinoconjunctivitis Quality of Life Questionnaire (MRQLQ) is a validated tool used to measure quality of life in people experiencing allergies (0 = not troubled to 6 = extremely troubled). Probiotics may improve quality of life during allergy season by increasing the percentage of regulatory T cells (Tregs) and inducing tolerance.Objective: The objective of this study was to determine whether consuming Lactobacillus gasseri KS-13, Bifidobacterium bifidum G9-1, and B...
March 2017: American Journal of Clinical Nutrition
https://www.readbyqxmd.com/read/28223974/determination-of-antibacterial-and-technological-properties-of-vaginal-lactobacilli-for-their-potential-application-in-dairy-products
#20
Lorenzo Siroli, Francesca Patrignani, Diana I Serrazanetti, Carola Parolin, Rogers A Ñahui Palomino, Beatrice Vitali, Rosalba Lanciotti
Functional foods could differently affect human health in relation to the gender. Recent studies have highlighted the anti-Candida and anti-Chlamydia activities of some Lactobacillus strains isolated from the vagina of healthy women. Considering these important beneficial activities on women's health, the preparation of functional food containing active vaginal lactobacilli can represent a great scientific challenge for the female gender. In this context, the aim of this work was to study some functional and technological properties of 17 vaginal strains belonging to the species Lactobacillus crispatus, Lactobacillus gasseri, and Lactobacillus vaginalis in the perspective to include them in dairy products...
2017: Frontiers in Microbiology
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