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miRNA Lung cancer

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https://www.readbyqxmd.com/read/29330288/epigenetically-regulated-chromosome-14q32-mirna-cluster-induces-metastasis-and-predicts-poor-prognosis-in-lung-adenocarcinoma-patients
#1
Margarita Gonzalez-Vallinas, Manuel Rodriguez-Paredes, Marco Albrecht, Carsten Sticht, Damian Stichel, Julian Gutekunst, Adriana Pitea, Steffen Sass, Francisco J Sánchez-Rivera, Justo L Bermejo, Jennifer Schmitt, Carolina De La Torre, Arne Warth, Fabian Theis, Nikola Mueller, Norbert Gretz, Thomas Muley, Michael Meister, Darjus F Tschaharganeh, Peter Schirmacher, Franziska Matthäus, Kai Breuhahn
Most lung cancer deaths are related to metastases, which indicates the necessity of detecting and inhibiting tumor cell dissemination. Here, we aimed to identify microRNAs (miRNAs) involved in metastasis of lung adenocarcinoma as prognostic biomarkers and therapeutic targets. To that end, lymph node metastasis-associated miRNAs were identified in The Cancer Genome Atlas (TCGA) lung adenocarcinoma patient cohort (sequencing data; n=449) and subsequently validated by RT-qPCR in an independent clinical cohort (n=108)...
January 12, 2018: Molecular Cancer Research: MCR
https://www.readbyqxmd.com/read/29321960/the-clinical-value-of-mir-193a-3p-in-non-small-cell-lung-cancer-and-its-potential-molecular-mechanism-explored-in-silico-using-rna-sequencing-and-microarray-data
#2
Xiang Gao, Rui-Xue Tang, Qiong-Ni Xie, Jia-Ying Lin, Hong-Lan Shi, Gang Chen, Zu-Yun Li
miR-193a-3p is a tumor-related miRNA playing an essential role in tumorigenesis and progression of non-small cell lung cancer (NSCLC). The objective of the present study was to investigate the relationship between miR-193a-3p expression and clinical value and to further explore the potential signaling of miR-193a-3p in the carcinogenesis of NSCLC. RNA-sequencing and microarray data were collected from the databases GEO, ArrayExpress and The Cancer Genome Atlas (TCGA). Furthermore, in silico assessments were performed to analyze the prospective pathways and networks of the target genes of miR-193a-3p...
January 2018: FEBS Open Bio
https://www.readbyqxmd.com/read/29317831/four-mirna-signature-as-a-prognostic-tool-for-lung-adenocarcinoma
#3
Yan Lin, Yufeng Lv, Rong Liang, Chunling Yuan, Jinyan Zhang, Dan He, Xiaowen Zheng, Jianfeng Zhang
Purpose: The aim of this study was to generate a novel miRNA expression signature to accurately predict prognosis for patients with lung adenocarcinoma (LUAD). Patients and methods: Using expression profiles downloaded from The Cancer Genome Atlas database, we identified multiple miRNAs with differential expression between LUAD and paired healthy tissues. We then evaluated the prognostic values of the differentially expressed miRNAs using univariate/multivariate Cox regression analysis...
2018: OncoTargets and Therapy
https://www.readbyqxmd.com/read/29301498/pcaf-mediated-acetylation-of-lin28b-increases-let-7-biogenesis-in-lung-adenocarcinoma-h1299-cells
#4
Ting-Ting Qu, Fei Chen, Jing Wang, Yan-Jun Zhang, Mo-Bin Cheng, Wen-Zheng Sun, Yu-Fei Shen, Ye Zhang
BACKGROUND: Lin28B and its paralog Lin28A are small RNA binding proteins that have similar inhibitory effects, although they target separate steps in the maturation of let-7 miRNAs in mammalian cells. Because Lin28B participates in the promotion and development of tumors mostly by blocking the let-7 tumor suppressor family members, we sought to explore the associated mechanisms to gain insights into how Lin28B might be decreased in human cancer cells to increase let-7 levels and reverse malignancy...
January 4, 2018: BMC Cancer
https://www.readbyqxmd.com/read/29299995/mirna-and-proteomic-dysregulation-in-non-small-cell-lung-cancer-in-response-to-cigarette-smoke
#5
Niraj Babu, Jayshree Advani, Hitendra S Solanki, Krishna Patel, Ankit P Jain, Aafaque Ahmad Khan, Aneesha Radhakrishnan, Nandini A Sahasrabuddhe, Premendu Prakash Mathur, Bipin Nair, T S Keshava Prasad, Xiaofei Chang, David Sidransky, Harsha Gowda, Aditi Chatterjee
BACKGROUND: Dysregulation of miRNAs is associated with the development of non-small cell lung cancer (NSCLC). It is imperative to study the dysregulation of miRNAs by cigarette smoke which will affect their targets, either leading to the overexpression of oncoproteins or downregulation of tumor suppressor proteins. OBJECTIVE AND METHODS: In this study, we carried out miRNA sequencing and SILAC-based proteomic analysis of H358 cells chronically exposed to cigarette smoke condensate...
January 3, 2018: MicroRNA
https://www.readbyqxmd.com/read/29291244/unveiling-massive-numbers-of-cancer-related-urinary-microrna-candidates-via-nanowires
#6
Takao Yasui, Takeshi Yanagida, Satoru Ito, Yuki Konakade, Daiki Takeshita, Tsuyoshi Naganawa, Kazuki Nagashima, Taisuke Shimada, Noritada Kaji, Yuta Nakamura, Ivan Adiyasa Thiodorus, Yong He, Sakon Rahong, Masaki Kanai, Hiroshi Yukawa, Takahiro Ochiya, Tomoji Kawai, Yoshinobu Baba
Analyzing microRNAs (miRNAs) within urine extracellular vesicles (EVs) is important for realizing miRNA-based, simple, and noninvasive early disease diagnoses and timely medical checkups. However, the inherent difficulty in collecting dilute concentrations of EVs (<0.01 volume %) from urine has hindered the development of these diagnoses and medical checkups. We propose a device composed of nanowires anchored into a microfluidic substrate. This device enables EV collections at high efficiency and in situ extractions of various miRNAs of different sequences (around 1000 types) that significantly exceed the number of species being extracted by the conventional ultracentrifugation method...
December 2017: Science Advances
https://www.readbyqxmd.com/read/29288987/machine-learning-based-prediction-of-brain-metastasis-of-patients-with-iiia-n2-lung-adenocarcinoma-by-a-three-mirna-signature
#7
Shuangtao Zhao, Jiangyong Yu, Luhua Wang
OBJECTIVES: MicroRNAs (miRNAs) play a key role in governing posttranscriptional regulation through binding to the mRNAs of target genes. This study is to assess miRNAs expression profiles for identifying brain metastasis-related miRNAs to develop the predictive model by microarray in tumor tissues. METHODS: For this study, we screened the significant brain metastasis-related miRNAs from 77 lung adenocarcinoma (LUAD) patients with brain metastasis (BM+) or non-brain metastasis (BM-)...
December 27, 2017: Translational Oncology
https://www.readbyqxmd.com/read/29286916/upregulation-of-serum-mir-494-predicts-poor-prognosis-in-non-small-cell-lung-cancer-patients
#8
Jiajia Zhang, Tong Wang, Yong Zhang, Hao Wang, Yubing Wu, Kunhe Liu, Chong Pei
OBJECTIVE: Emerging studies show that microRNAs (miRNAs) play a essential role in tumorigenesis. Deregulation of miR-494 is frequently observed in various human cancers including non-small cell lung cancer (NSCLC). However, little is known about the clinical significance of serum miR-494. The aim of this study was to investigate the diagnostic and prognostic value of serum miR-494 for NSCLC. METHODS: We first compared miR-494 levels between NSCLC cell lines and lung bronchus epithelial cell line...
December 18, 2017: Cancer Biomarkers: Section A of Disease Markers
https://www.readbyqxmd.com/read/29286099/downregulation-of-matrix-metalloproteinase-14-by-the-antitumor-mirna-mir-150-5p-inhibits-the-aggressiveness-of-lung-squamous-cell-carcinoma-cells
#9
Takayuki Suetsugu, Keiichi Koshizuka, Naohiko Seki, Keiko Mizuno, Atsushi Okato, Takayuki Arai, Shunsuke Misono, Akifumi Uchida, Tomohiro Kumamoto, Hiromasa Inoue
In the present study, in order to elucidate the aggressive nature of lung squamous cell carcinoma (LUSQ), we investigated the oncogenic RNA networks regulated by antitumor microRNAs (miRNAs or miRs) in LUSQ cells. The analysis of our original miRNA expression signatures of human cancers revealed that microRNA‑150‑5p (miR‑150‑5p) was downregulated in various types of cancer, indicating that miR‑150‑5p acts as an antitumor miRNA by targeting several oncogenic genes. Thus, the aims of this study were to investigate the antitumor roles of miR‑150‑5p in LUSQ cells and to identify oncogenes regulated by miR‑150‑5p that are involved in the aggressive behavior of LUSQ...
December 21, 2017: International Journal of Oncology
https://www.readbyqxmd.com/read/29281186/microrna-204-deregulation-in-lung-adenocarcinoma-controls-the-biological-behaviors-of-endothelial-cells-potentially-by-modulating-janus-kinase-2-signal-transducer-and-activator-of-transcription-3-pathway
#10
Xiangdong Liu, Xiang Gao, Wentao Zhang, Tianyi Zhu, Wei Bi, Yanrong Zhang
MicroRNAs (miRNAs) have been implicated in a wide range of biological processes including angiogenesis. MiR-204 was identified as a tumor suppressor in multiple cancer types, including lung adenocarcinoma. However, the function of miR-204 in lung tumor angiogenesis remains unknown. In this study, we found that the miR-204 expression was decreased in lung adenocarcinoma based on the cancer genome atlas (TCGA) analysis and gain-of-function experiment showed that miR-204 promoted cancer cell apoptosis and suppressed cell proliferation, migration in vitro and tumor growth in vivo...
January 2018: IUBMB Life
https://www.readbyqxmd.com/read/29281000/a-high-resolution-map-of-the-human-small-non-coding-transcriptome
#11
Tobias Fehlmann, Christina Backes, Julia Alles, Ulrike Fischer, Martin Hart, Fabian Kern, Hilde Langseth, Trine Rounge, Sinan Ugur Umu, Mustafa Kahraman, Thomas Laufer, Jan Haas, Cord Staehler, Nicole Ludwig, Matthias Hübenthal, Benjamin Meder, Andre Franke, Hans-Peter Lenhof, Eckart Meese, Andreas Keller
Motivation: While the amount of small non-coding RNA sequencing data is continuously increasing, it is still unclear to which extent small RNAs are represented in the human genome. Results: In this study we analyzed 303 billion sequencing reads from nearly 25,000 data sets to answer this question. We determined that 0.8% of the human genome are reliably covered by 874,123 regions with an average length of 31nt. On the basis of these regions, we found that among the known small non-coding RNA classes, microRNAs were the most prevalent...
December 21, 2017: Bioinformatics
https://www.readbyqxmd.com/read/29277611/long-non-coding-rna-pvt1-5-promotes-cell-proliferation-by-regulating-mir-126-slc7a5-axis-in-lung-cancer
#12
Hongliang Li, Shuxian Chen, Jia Liu, Xiaopeng Guo, Xudong Xiang, Tianqi Dong, Pengzhan Ran, Qian Li, Bei Zhu, Xiyu Zhang, Dan Wang, Chunjie Xiao, Shangyong Zheng
Dysregulated long non-coding RNAs (lncRNAs) and microRNAs (miRNAs) play key roles in the development of human cancers. The lncRNA plasmacytoma variant translocation 1 (PVT1) is reported to be an oncogene in a variety of cancers. However, the roles of PVT1-5 and its related miRNAs in lung cancer are poorly understood. In this study, we found that PVT1-5 expression was significantly increased in lung cancer tissues and cell lines. By using biotin-labeled lncRNA-PVT1-5 probe for miRNA in vivo precipitation (miRIP) in lung cancer cells and dual-luciferase reporterassays, we identified that miR-126 was associated with lncRNA-PVT1-5...
December 23, 2017: Biochemical and Biophysical Research Communications
https://www.readbyqxmd.com/read/29258605/mir-105-93-3p-promotes-chemoresistance-and-circulating-mir-105-93-3p-acts-as-a-diagnostic-biomarker-for-triple-negative-breast-cancer
#13
Hao-Yi Li, Jui-Lin Liang, Yao-Lung Kuo, Hao-Hsien Lee, Marcus J Calkins, Hong-Tai Chang, Forn-Chia Lin, Yu-Chia Chen, Tai-I Hsu, Michael Hsiao, Luo-Ping Ger, Pei-Jung Lu
BACKGROUND: Triple negative breast cancer (TNBC) lacks both early detection biomarkers and viable targeted therapeutics. Moreover, chemotherapy only produces 20-30% pathologic complete response. Because miRNAs are frequently dysregulated in breast cancer and have broad tissue effects, individual or combinations of circulating miRNAs may serve as ideal diagnostic, predictive or prognostic biomarkers, as well as therapeutic targets. Understanding the role and mechanism of dysregulated miRNAs in TNBC may help to develop novel diagnostic and prognostic strategy for TNBC patients...
December 19, 2017: Breast Cancer Research: BCR
https://www.readbyqxmd.com/read/29246293/mir-124-inhibits-lung-tumorigenesis-induced-by-k-ras-mutation-and-nnk
#14
Hua Jin, Qing Li, Fenghao Cao, Shu-Nan Wang, Ren-Tao Wang, Yun Wang, Qun-You Tan, Cheng-Run Li, Hua Zou, Dong Wang, Cheng-Xiong Xu
Dysregulated miRNAs play important role in K-ras mutation or smoking caused lung tumorigenesis. Here, we investigate the role and mechanism of miR-124 in K-ras mutation or smoking-caused lung tumorigenesis and evaluate the therapeutic potential of miR-124 agomiR in K-ras mutation or smoking-caused lung cancer treatment. Our data show that smoking suppresses miR-124 expression, and decreased miR-124 expression is inversely correlated with the p-Akt level and predicts poor overall survival in non-small-cell lung cancer (NSCLC) patients...
December 15, 2017: Molecular Therapy. Nucleic Acids
https://www.readbyqxmd.com/read/29241190/circrna-expression-profile-in-early-stage-lung-adenocarcinoma-patients
#15
Jiangmin Zhao, Le Li, Qian Wang, Hongxiu Han, Qing Zhan, Ming Xu
BACKGROUND/AIMS: Lung adenocarcinoma, a form of non-small cell lung cancer with high lethality at an advanced stage, is becoming more common in women, non- or never-smokers, and even young adults. At present, there are still no effective early diagnosis methods for patients to be cured in a timely manner. Circular RNAs (circRNAs), which are stable and conserved non-coding RNA in mammalian cells, have been reported to be widely involved in the processes of cancer disease. However, it is still a puzzle as to which specific circRNAs are involved in the development of early-stage lung adenocarcinoma...
December 12, 2017: Cellular Physiology and Biochemistry
https://www.readbyqxmd.com/read/29239816/mir-9-5p-promotes-cell-growth-and-metastasis-in-non-small-cell-lung-cancer-through-the-repression-of-tgfbr2
#16
Gang Li, Fang Wu, Han Yang, Xia Deng, Yawei Yuan
BACKGROUND: Increasing evidence indicates that the dysregulation of microRNAs (miRNAs) play critical roles tumor progression and metastasis, but very few papers had reported the function of miR-9-5p in lung cancer, especially in NSCLCs. METHODS: In this study, we investigated the role of miR-9-5p in non-small cell lung cancers (NSCLCs). MiR-9-5p level were analyzed in 62 clinical NSCLC lung tissue samples and adjacent normal lung tissues by RT-PCR. The target of miR-9-5p was predicted by TargetScan and luciferase reporter assay was used to verify the binding site of miR-9-5p on TGFBR2 mRNA...
November 24, 2017: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/29237428/nkx2-1-expression-as-a-prognostic-marker-in-early-stage-non-small-cell-lung-cancer
#17
Jorge Moisés, Alfons Navarro, Sandra Santasusagna, Nuria Viñolas, Laureano Molins, José Ramirez, Jeisson Osorio, Adela Saco, Joan Josep Castellano, Carmen Muñoz, Sara Morales, Mariano Monzó, Ramón María Marrades
BACKGROUND: NKX2-1, a key molecule in lung development, is highly expressed in non-small cell lung cancer (NSCLC), particularly in lung adenocarcinoma (ADK), where it is a diagnostic marker. Studies of the prognostic role of NKX2-1 in NSCLC have reported contradictory findings. Two microRNAs (miRNAs) have been associated with NKX2-1: miR-365, which targets NKX2-1; and miR-33a, which is downstream of NKX2-1. We have examined the effect of NKX2-1, miR-365 and miR-33a on survival in a cohort of early-stage NSCLC patients and in sub-groups of patients classified according to the mutational status of TP53, KRAS, and EGFR...
December 13, 2017: BMC Pulmonary Medicine
https://www.readbyqxmd.com/read/29237393/micrornas-downregulation-in-cancer-is-associated-with-guanine-enrichment-in-the-terminal-loop-sequences-of-their-precursors
#18
Amit Cohen, Mario Alberto Burgos-Aceves, Yoav Smith
A global repression in microRNA (miRNA) expression is a phenomenon observed in different types of cancer. Herein, we show an association of miRNAs downregulation in cancer, with guanine (G) enrichment in the terminal loop sequences of their precursors. High G (and GG) content was mostly found in repressed miRNAs of breast, lung and ovary cancers, predominantly in poorly differentiated tumors. The mature sequences of repressed miRNAs had significantly low G level and were enriched with an ACA motif. These results suggest a new link between G enrichment of precursor miRNAs terminal loops and carcinogenesis, and the possible association of specific sequence motifs with the regulation of their expression...
December 13, 2017: MicroRNA
https://www.readbyqxmd.com/read/29237164/mir-124-inhibits-growth-and-enhances-radiation-induced-apoptosis-in-non-small-cell-lung-cancer-by-inhibiting-stat3
#19
Mengjie Wang, Bi Meng, Yangchen Liu, Jingwen Yu, Qiaoyun Chen, Yangchen Liu
BACKGROUND/AIMS: A growing body of evidence indicates that the abnormal expression of microRNAs (miRNAs) play an important role in sensitizing the cellular response to ionizing radiation (IR). The aim of this study was to investigate whether the expression of miR-124 correlated with radiosensitivity in the context of non-small-cell lung carcinoma (NSCLC). METHODS: Quantitative reverse transcription polymerase chain reaction (RT-PCR) was used to quantify miR-124 expression in NSCLC tissues and cell lines...
December 11, 2017: Cellular Physiology and Biochemistry
https://www.readbyqxmd.com/read/29236960/microrna-128-3p-mediated-depletion-of-drosha-promotes-lung-cancer-cell-migration
#20
Tania Frixa, Andrea Sacconi, Mario Cioce, Giuseppe Roscilli, Fabiana Fosca Ferrara, Luigi Aurisicchio, Claudio Pulito, Stefano Telera, Maria Antonia Carosi, Paola Muti, Sabrina Strano, Sara Donzelli, Giovanni Blandino
Alteration in microRNAs (miRNAs) expression is a frequent finding in human cancers. In particular, widespread miRNAs down-regulation is a hallmark of malignant transformation. In the present report, we showed that the miR-128-3p, which is up-regulated in lung cancer tissues, has Drosha and Dicer, two key enzymes of miRNAs processing, as the main modulation targets leading to the widespread down-regulation of miRNA expression. We observed that the miRNAs downregulation induced by miR-128-3p contributed to the tumorigenic properties of lung cancer cells...
December 11, 2017: Carcinogenesis
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