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https://www.readbyqxmd.com/read/28925085/-18-f-fdg-pet-ct-as-adjunctive-diagnostic-modalities-in-canine-fever-of-unknown-origin
#1
Megan Grobman, Leah Cohn, Stephanie Knapp, Jeffrey N Bryan, Carol Reinero
Fever of unknown origin (FUO) is a persistent or recurrent fever for which the underlying source has not been identified despite diagnostic investigation. In people, (18) F-fluoro-2-deoxyglucose positron emission tomography ((18) F-FDG-PET) alone or in combination with computed tomography (CT) is often beneficial in detecting the source of fever when other diagnostics have failed. Veterinary reports describing use of these modalities in animals with fever of unknown origin are currently lacking. Aims of this retrospective case series were to describe (18) F-FDG-PET or (18) F-FDG-PET/CT findings in a group of dogs with fever of unknown origin...
September 18, 2017: Veterinary Radiology & Ultrasound
https://www.readbyqxmd.com/read/28903168/-sharing-bacterial-microbiota-between-owners-and-their-pets-dogs-cats
#2
Jan Wipler, Zuzana Čermáková, Tomáš Hanzálek, Hana Horáková, Helena Žemličková
INTRODUCTION: The microbiological aspect of a relationship between pets (dogs/cats) and their owners is mainly concerned with the incidence of shared bacterial species, in particular potential pathogens. Given the great popularity of sharing homes with pets (dogs/cats) in the Czech Republic, there is an increased possibility of communication between microbiota of the two macroorganisms (pet and owner). The aim of the study was to determine the biodiversity of shared bacteria and possibility of exchange of genes of resistance to antimicrobial agents between potential pathogens based on the close relationship between pets and humans...
June 2017: Klinická Mikrobiologie a Infekc̆ní Lékar̆ství
https://www.readbyqxmd.com/read/28883003/discovery-of-human-similar-gene-fusions-in-canine-cancers
#3
Ronan Ulvé, Mélanie Rault, Mathieu Bahin, Laetitia Lagoutte, Jérôme Abadie, Clotilde De Brito, Jean-Michel Coindre, Nadine Botherel, Audrey Rousseau, Valentin Wucher, Edouard Cadieu, Catherine Thieblemont, Christophe Hitte, Laurence Cornevin, Florian Cabillic, Laura Bachelot, David Gilot, Benoit Hennuy, Thierry Guillaudeux, Arnaud Le Goff, Thomas Derrien, Benoît Hédan, Catherine André
Canine cancers represent a tremendous natural resource due to their incidence and striking similarities to human cancers, sharing similar clinical and pathological features as well as oncogenic events including identical somatic mutations. Considering the importance of gene fusions as driver alterations, we explored their relevance in canine cancers. We focused on three distinct human-comparable canine cancers representing different tissues and embryonic origins. Through RNA-Seq, we discovered similar gene fusions as those found in their human counterparts: IGK-CCND3 in B-cell lymphoma, MPB-BRAF in glioma, and COL3A1-PDGFB in dermatofibrosarcoma protuberans-like...
September 7, 2017: Cancer Research
https://www.readbyqxmd.com/read/28851894/activated-mesenchymal-stem-cells-interact-with-antibiotics-and-host-innate-immune-responses-to-control-chronic-bacterial-infections
#4
Valerie Johnson, Tracy Webb, Annalis Norman, Jonathan Coy, Jade Kurihara, Daniel Regan, Steven Dow
Chronic bacterial infections associated with biofilm formation are often difficult to resolve without extended courses of antibiotic therapy. Mesenchymal stem cells (MSC) exert antibacterial activity in vitro and in acute bacterial infection models, but their activity in chronic infection with biofilm models has not been previously investigated. Therefore, we studied the effects of MSC administration in mouse and dog models of chronic infections associated with biofilms. Mice with chronic Staphylococcus aureus implant infections were treated by i...
August 29, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28708601/synergistic-and-targeted-therapy-with-a-procaspase-3-activator-and-temozolomide-extends-survival-in-glioma-rodent-models-and-is-feasible-for-the-treatment-of-canine-malignant-glioma-patients
#5
Avadhut D Joshi, Rachel C Botham, Lisa J Schlein, Howard S Roth, Antonella Mangraviti, Alexandra Borodovsky, Betty Tyler, Steve Joslyn, Jayme S Looper, Michael Podell, Timothy M Fan, Paul J Hergenrother, Gregory J Riggins
PURPOSE: Glioblastoma is a deadly brain cancer with a median survival time of ~15 months. Ionizing radiation plus the DNA alkylator temozolomide (TMZ) is the current standard therapy. PAC-1, a procaspase-3 activating small molecule, is blood-brain barrier penetrant and has previously demonstrated ability to synergize with diverse pro-apoptotic chemotherapeutics. We studied if PAC-1 could enhance the activity of TMZ, and whether addition of PAC-1 to standard treatment would be feasible in spontaneous canine malignant gliomas...
July 7, 2017: Oncotarget
https://www.readbyqxmd.com/read/28691624/hospitals-test-if-therapy-dogs-can-aid-children-s-recovery
#6
Matthew Mckew
Children undergoing hospital treatment are being supported by therapy dogs in a new study to establish if the pets are beneficial to their recovery.
July 10, 2017: Nursing Children and Young People
https://www.readbyqxmd.com/read/28665340/the-buffer-effect-of-therapy-dog-exposure-on-stress-reactivity-in-undergraduate-students
#7
Alexandra J Fiocco, Anastasia M Hunse
Stress is an insidious health risk that is commonly reported among university students. While research suggests that dog exposure may facilitate recovery from a stress response, little is known about the buffer effect of dog exposure on the stress response to a future stressor. This study examined whether interaction with a therapy dog could reduce the strength of the physiological stress response when exposed to a subsequent stressor. Sixty-one university students were randomly assigned to either a therapy dog (TD, n = 31) or a no-dog control (C, n = 30) group...
June 30, 2017: International Journal of Environmental Research and Public Health
https://www.readbyqxmd.com/read/28487862/naturally-occurring-canine-invasive-urinary-bladder-cancer-a-complementary-animal-model-to-improve-the-success-rate-in-human-clinical-trials-of-new-cancer-drugs
#8
REVIEW
Christopher M Fulkerson, Deepika Dhawan, Timothy L Ratliff, Noah M Hahn, Deborah W Knapp
Genomic analyses are defining numerous new targets for cancer therapy. Therapies aimed at specific genetic and epigenetic targets in cancer cells as well as expanded development of immunotherapies are placing increased demands on animal models. Traditional experimental models do not possess the collective features (cancer heterogeneity, molecular complexity, invasion, metastasis, and immune cell response) critical to predict success or failure of emerging therapies in humans. There is growing evidence, however, that dogs with specific forms of naturally occurring cancer can serve as highly relevant animal models to complement traditional models...
2017: International Journal of Genomics
https://www.readbyqxmd.com/read/28481317/dogs-in-the-workplace-a-review-of-the-benefits-and-potential-challenges
#9
REVIEW
Anne M Foreman, Margaret K Glenn, B Jean Meade, Oliver Wirth
Pet dogs, therapy dogs, and service dogs can be seen in workplaces with increasing frequency. Although dogs may provide many benefits to employees and employers, their presence may introduce additional hazards and concerns to the work environment. Therefore, decisions to accept dogs in the workplace may include many considerations including the health, safety, and well-being of employees, legal and cultural sensitivities, and animal welfare. The present paper serves to introduce the issue of dogs in the workplace and outline the potential benefits and challenges to their presence...
May 8, 2017: International Journal of Environmental Research and Public Health
https://www.readbyqxmd.com/read/28291397/evaluation-of-the-impacts-of-epilepsy-in-dogs-on-their-caregivers
#10
Julie A Nettifee, Karen R Munana, Emily H Griffith
Epilepsy is a common problem in dogs, and management of this chronic disorder requires a substantial commitment on the part of the pet owner. The aim of this study was to evaluate the impact of epilepsy in dogs on their owners, utilizing an online survey tool. A questionnaire was developed to explore a variety of factors, including seizure history, treatment, outcome, quality of life, costs associated with therapy, and sources of support. A total of 225 responses were obtained. The majority of respondents reported positive scores for overall quality of life, although scores were significantly lower for dogs with poorly controlled epilepsy and medication-related adverse effects...
May 2017: Journal of the American Animal Hospital Association
https://www.readbyqxmd.com/read/28283317/pilot-study-to-determine-the-feasibility-of-radiation-therapy-for-dogs-with-right-atrial-masses-and-hemorrhagic-pericardial-effusion
#11
M W Nolan, M M Arkans, D LaVine, T DeFrancesco, J A Myers, E H Griffith, L P Posner, B W Keene, S P Tou, T L Gieger
OBJECTIVES: To determine the short-term safety and biologic activity of radiation therapy (RT) for presumptive cardiac hemangiosarcoma in pet dogs. ANIMALS: Six dogs with echocardiographic evidence of a right atrial/auricular mass, and hemorrhagic pericardial effusion, were enrolled in a prospective, single-arm clinical trial. METHODS: A single fraction of 12 Gy was delivered using conformal external beam irradiation. Serum cardiac troponin I and plasma concentrations of vascular endothelial growth factor were quantified before, 4 and 24 h after RT...
March 7, 2017: Journal of Veterinary Cardiology: the Official Journal of the European Society of Veterinary Cardiology
https://www.readbyqxmd.com/read/28222142/evaluation-of-18-f-fluoro-2-deoxyglucose-fdg-positron-emission-tomography-computed-tomography-pet-ct-as-a-staging-and-monitoring-tool-for-dogs-with-stage-2-splenic-hemangiosarcoma-a-pilot-study
#12
Antonella Borgatti, Amber L Winter, Kathleen Stuebner, Ruth Scott, Christopher P Ober, Kari L Anderson, Daniel A Feeney, Daniel A Vallera, Joseph S Koopmeiners, Jaime F Modiano, Jerry Froelich
Positron Emission Tomography-Computed Tomography (PET-CT) is routinely used for staging and monitoring of human cancer patients and is becoming increasingly available in veterinary medicine. In this study, 18-fluorodeoxyglucose (18FDG)-PET-CT was used in dogs with naturally occurring splenic hemangiosarcoma (HSA) to assess its utility as a staging and monitoring modality as compared to standard radiography and ultrasonography. Nine dogs with stage-2 HSA underwent 18FDG-PET-CT following splenectomy and prior to commencement of chemotherapy...
2017: PloS One
https://www.readbyqxmd.com/read/28218025/dental-implants-and-incisor-bridge-placement-in-a-dog
#13
Rocco E Mele, Anthony Caiafa, Gregori M Kurtzman
Veterinary dentistry has tended to follow the trends and advancements in the human dental field. As for any procedure performed on a patient, whether human or animal, an informed decision is based on the available evidence regarding treatment options. This is certainly true for the more involved treatments in veterinary dentistry which can include the disciplines of endodontics and dental implantology. A number of published case reports have been accepted by the specialty that endodontic therapy is indeed a predictable and a valuable service that can be offered to pet owners...
December 2016: Journal of Veterinary Dentistry
https://www.readbyqxmd.com/read/28168937/outcomes-of-spatially-fractionated-radiotherapy-grid-for-bulky-soft-tissue-sarcomas-in-a-large-animal-model
#14
Michael W Nolan, Tracy L Gieger, Alexander A Karakashian, Mariana N Nikolova-Karakashian, Lysa P Posner, Donald M Roback, Judith N Rivera, Sha Chang
GRID directs alternating regions of high- and low-dose radiation at tumors. A large animal model mimicking the geometries of human treatments is needed to complement existing rodent systems (eg, microbeam) and clarify the physical and biological attributes of GRID. A pilot study was undertaken in pet dogs with spontaneous soft tissue sarcomas to characterize responses to GRID. Subjects were treated with either 20 Gy (3 dogs) or 25 Gy (3 dogs), delivered using 6 MV X-rays and a commercial GRID collimator. Acute toxicity and tumor responses were assessed 2, 4, and 6 weeks later...
January 1, 2017: Technology in Cancer Research & Treatment
https://www.readbyqxmd.com/read/28119466/effects-of-the-dietary-protein-and-carbohydrate-ratio-on-gut-microbiomes-in-dogs-of-different-body-conditions
#15
Qinghong Li, Christian L Lauber, Gail Czarnecki-Maulden, Yuanlong Pan, Steven S Hannah
Obesity has become a health epidemic in both humans and pets. A dysbiotic gut microbiota has been associated with obesity and other metabolic disorders. High-protein, low-carbohydrate (HPLC) diets have been recommended for body weight loss, but little is known about their effects on the canine gut microbiome. Sixty-three obese and lean Labrador retrievers and Beagles (mean age, 5.72 years) were fed a common baseline diet for 4 weeks in phase 1, followed by 4 weeks of a treatment diet, specifically, the HPLC diet (49...
January 24, 2017: MBio
https://www.readbyqxmd.com/read/28109246/sensitivity-of-osteosarcoma-cells-to-hdac-inhibitor-ar-42-mediated-apoptosis
#16
Sridhar Murahari, Aimee L Jalkanen, Samuel K Kulp, Ching-Shih Chen, Jaime F Modiano, Cheryl A London, William C Kisseberth
BACKGROUND: Osteosarcoma (OS) is the most common primary bone tumor in both humans and dogs and is the second leading cause of cancer related deaths in children and young adults. Limb sparing surgery along with chemotherapy has been the mainstay of treatment for OS. Many patients are not cured with current therapies, presenting a real need for developing new treatments. Histone deacetylase (HDAC) inhibitors are a promising new class of anticancer agents. In this study, we investigated the activity of the novel HDAC inhibitor AR-42 in a panel of human and canine OS cell lines...
January 21, 2017: BMC Cancer
https://www.readbyqxmd.com/read/28097286/-pain-therapy-in-small-pets
#17
Sabine Tacke, Andrea Gollwitzer, Lukas Grammel, Julia Henke
Although many advances in pain therapy have been made in recent years, pain therapy is more difficult in the small domestic animal than in cats and dogs. However, there is the ethical obligation that these animals also receive adequate pain therapy. An analgesic is rarely authorized for use in small pets, with pharmacological investigations often lacking and dosages frequently only determined empirically. The small size of the animals often requires a higher dose per kilogram bodyweight compared to cats and dogs...
February 9, 2017: Tierärztliche Praxis. Ausgabe K, Kleintiere/Heimtiere
https://www.readbyqxmd.com/read/28048581/su-c-204-06-monte-carlo-dose-calculation-for-kilovoltage-x-ray-psoralen-activated-cancer-therapy-x-pact-preliminary-results
#18
S Mein, R Gunasingha, M Nolan, M Oldham, J Adamson
PURPOSE: X-PACT is an experimental cancer therapy where kV x-rays are used to photo-activate anti-cancer therapeutics through phosphor intermediaries (phosphors that absorb x-rays and re-radiate as UV light). Clinical trials in pet dogs are currently underway (NC State College of Veterinary Medicine) and an essential component is the ability to model the kV dose in these dogs. Here we report the commissioning and characterization of a Monte Carlo (MC) treatment planning simulation tool to calculate X-PACT radiation doses in canine trials...
June 2016: Medical Physics
https://www.readbyqxmd.com/read/27896194/osteomyelitis-following-domestic-animal-bites-to-the-hand-two-case-reports-and-practical-guidelines
#19
Jung Soo Lim, Jin Hwan Byun, Kyung Hee Min, Hye Kyung Lee, Yun Sun Choi
Recently, the number of cases of animal bite wounds has increased significantly in concordance with an increase in the pet population around the world. The authors report two rare cases of osteomyelitis of the phalanx following cat and dog bites. On initial physical examination, signs of a severe infection were observed. Radiographs of both patients showed the presence of osteomyelitis, and in one of the patients, the diagnosis was confirmed with a bone biopsy. After use of empirical antibiotics, intravenous antibiotic therapy that matched the identified bacterium's sensitivity was initiated, and at the same time, secure dressing including debridement was performed to induce secondary healing...
November 2016: Archives of Plastic Surgery
https://www.readbyqxmd.com/read/27830776/artificial-blood-for-dogs
#20
Kana Yamada, Kyoko Yokomaku, Moeka Kureishi, Motofusa Akiyama, Kiyohito Kihira, Teruyuki Komatsu
There is no blood bank for pet animals. Consequently, veterinarians themselves must obtain "blood" for transfusion therapy. Among the blood components, serum albumin and red blood cells (RBCs) are particularly important to save lives. This paper reports the synthesis, structure, and properties of artificial blood for the exclusive use of dogs. First, recombinant canine serum albumin (rCSA) was produced using genetic engineering with Pichia yeast. The proteins showed identical features to those of the native CSA derived from canine plasma...
November 10, 2016: Scientific Reports
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