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https://www.readbyqxmd.com/read/28168937/outcomes-of-spatially-fractionated-radiotherapy-grid-for-bulky-soft-tissue-sarcomas-in-a-large-animal-model
#1
Michael W Nolan, Tracy L Gieger, Alexander A Karakashian, Mariana N Nikolova-Karakashian, Lysa P Posner, Donald M Roback, Judith N Rivera, Sha Chang
GRID directs alternating regions of high- and low-dose radiation at tumors. A large animal model mimicking the geometries of human treatments is needed to complement existing rodent systems (eg, microbeam) and clarify the physical and biological attributes of GRID. A pilot study was undertaken in pet dogs with spontaneous soft tissue sarcomas to characterize responses to GRID. Subjects were treated with either 20 Gy (3 dogs) or 25 Gy (3 dogs), delivered using 6 MV X-rays and a commercial GRID collimator. Acute toxicity and tumor responses were assessed 2, 4, and 6 weeks later...
January 1, 2017: Technology in Cancer Research & Treatment
https://www.readbyqxmd.com/read/28119466/effects-of-the-dietary-protein-and-carbohydrate-ratio-on-gut-microbiomes-in-dogs-of-different-body-conditions
#2
Qinghong Li, Christian L Lauber, Gail Czarnecki-Maulden, Yuanlong Pan, Steven S Hannah
: Obesity has become a health epidemic in both humans and pets. A dysbiotic gut microbiota has been associated with obesity and other metabolic disorders. High-protein, low-carbohydrate (HPLC) diets have been recommended for body weight loss, but little is known about their effects on the canine gut microbiome. Sixty-three obese and lean Labrador retrievers and Beagles (mean age, 5.72 years) were fed a common baseline diet for 4 weeks in phase 1, followed by 4 weeks of a treatment diet, specifically, the HPLC diet (49...
January 24, 2017: MBio
https://www.readbyqxmd.com/read/28109246/sensitivity-of-osteosarcoma-cells-to-hdac-inhibitor-ar-42-mediated-apoptosis
#3
Sridhar Murahari, Aimee L Jalkanen, Samuel K Kulp, Ching-Shih Chen, Jaime F Modiano, Cheryl A London, William C Kisseberth
BACKGROUND: Osteosarcoma (OS) is the most common primary bone tumor in both humans and dogs and is the second leading cause of cancer related deaths in children and young adults. Limb sparing surgery along with chemotherapy has been the mainstay of treatment for OS. Many patients are not cured with current therapies, presenting a real need for developing new treatments. Histone deacetylase (HDAC) inhibitors are a promising new class of anticancer agents. In this study, we investigated the activity of the novel HDAC inhibitor AR-42 in a panel of human and canine OS cell lines...
January 21, 2017: BMC Cancer
https://www.readbyqxmd.com/read/28097286/-pain-therapy-in-small-pets
#4
Sabine Tacke, Andrea Gollwitzer, Lukas Grammel, Julia Henke
Although many advances in pain therapy have been made in recent years, pain therapy is more difficult in the small domestic animal than in cats and dogs. However, there is the ethical obligation that these animals also receive adequate pain therapy. An analgesic is rarely authorized for use in small pets, with pharmacological investigations often lacking and dosages frequently only determined empirically. The small size of the animals often requires a higher dose per kilogram bodyweight compared to cats and dogs...
February 9, 2017: Tierärztliche Praxis. Ausgabe K, Kleintiere/Heimtiere
https://www.readbyqxmd.com/read/28048581/su-c-204-06-monte-carlo-dose-calculation-for-kilovoltage-x-ray-psoralen-activated-cancer-therapy-x-pact-preliminary-results
#5
S Mein, R Gunasingha, M Nolan, M Oldham, J Adamson
PURPOSE: X-PACT is an experimental cancer therapy where kV x-rays are used to photo-activate anti-cancer therapeutics through phosphor intermediaries (phosphors that absorb x-rays and re-radiate as UV light). Clinical trials in pet dogs are currently underway (NC State College of Veterinary Medicine) and an essential component is the ability to model the kV dose in these dogs. Here we report the commissioning and characterization of a Monte Carlo (MC) treatment planning simulation tool to calculate X-PACT radiation doses in canine trials...
June 2016: Medical Physics
https://www.readbyqxmd.com/read/27896194/osteomyelitis-following-domestic-animal-bites-to-the-hand-two-case-reports-and-practical-guidelines
#6
Jung Soo Lim, Jin Hwan Byun, Kyung Hee Min, Hye Kyung Lee, Yun Sun Choi
Recently, the number of cases of animal bite wounds has increased significantly in concordance with an increase in the pet population around the world. The authors report two rare cases of osteomyelitis of the phalanx following cat and dog bites. On initial physical examination, signs of a severe infection were observed. Radiographs of both patients showed the presence of osteomyelitis, and in one of the patients, the diagnosis was confirmed with a bone biopsy. After use of empirical antibiotics, intravenous antibiotic therapy that matched the identified bacterium's sensitivity was initiated, and at the same time, secure dressing including debridement was performed to induce secondary healing...
November 2016: Archives of Plastic Surgery
https://www.readbyqxmd.com/read/27830776/artificial-blood-for-dogs
#7
Kana Yamada, Kyoko Yokomaku, Moeka Kureishi, Motofusa Akiyama, Kiyohito Kihira, Teruyuki Komatsu
There is no blood bank for pet animals. Consequently, veterinarians themselves must obtain "blood" for transfusion therapy. Among the blood components, serum albumin and red blood cells (RBCs) are particularly important to save lives. This paper reports the synthesis, structure, and properties of artificial blood for the exclusive use of dogs. First, recombinant canine serum albumin (rCSA) was produced using genetic engineering with Pichia yeast. The proteins showed identical features to those of the native CSA derived from canine plasma...
November 10, 2016: Scientific Reports
https://www.readbyqxmd.com/read/27792129/the-effect-of-pet-remedy-on-the-behaviour-of-the-domestic-dog-canis-familiaris
#8
Sienna Taylor, Joah Madden
Stress-affected behaviour in companion animals can have an adverse effect on animal health and welfare and their relationships with humans. This stress can be addressed using chemical treatments, often in conjunction with behavioural therapies. Here, we investigated the efficacy of one commercial pharmacological intervention, Pet Remedy, advertised as a natural stress relief product for mammals. We aimed to see whether the product lowered stress-affected behaviour in dogs placed in a non-familiar environment...
October 25, 2016: Animals: An Open Access Journal From MDPI
https://www.readbyqxmd.com/read/27547289/emerging-cardiovascular-risk-research-impact-of-pets-on-cardiovascular-risk-prevention
#9
Pamela J Schreiner
Animals interact with humans in multiple ways, including as therapy and service animals, commercially as livestock, as wildlife, and in zoos. But the most common interaction is as companion animals in our homes, with an estimated 180 million cats and dogs living in US households. While pet ownership has been reported to have many health benefits, the findings are inconsistent. Cardiovascular risk factors such as lipids, glucose, obesity, and heart rate variability have improved, worsened, or remained the same in the limited number of studies considering companion animals...
February 2016: Current Cardiovascular Risk Reports
https://www.readbyqxmd.com/read/27484718/effects-and-synergy-of-feed-ingredients-on-canine-neoplastic-cell-proliferation
#10
Corri B Levine, Julie Bayle, Vincent Biourge, Joseph J Wakshlag
BACKGROUND: Adjunctive use of nutraceuticals in human cancer has shown promise, but little work has been done in canine neoplasia. Previous human research has shown that polyphenols and carotenoids can target multiple pathways in vitro and in vivo. These compounds could synergize or antagonize with currently used chemotherapies, either increasing or decreasing the effectiveness of these drugs. Considering the routine and well controlled feeding practices of most dogs, the use of nutraceuticals incorporated into pet food is attractive, pending proof that the extracts are able to improve remission rates...
August 2, 2016: BMC Veterinary Research
https://www.readbyqxmd.com/read/27357532/pre-multidrug-resistant-mycobacterium-tuberculosis-infection-causing-fatal-enteric-disease-in-a-dog-from-a-family-with-history-of-human-tuberculosis
#11
M G Ribeiro, M C F Lima, M M J Franco, J Megid, L M Soares, L H A Machado, M Miyata, F R Pavan, M B Heinemann, A F Souza Filho, G H B Lara, O C Sanches, C D C Sanches, F J P Listoni, A C Paes
This report describes a fatal case of a pet dog with major enteric signs owned by a family that has experienced cases of pulmonary tuberculosis (TB) in the household. Clinical and epidemiological aspects, imaging data, microbiological, haematological and histopathological examinations were assessed to diagnosis of disease. gyrB-RFLP, spoligotyping and MIRU-VNTR allowed molecular detection of M. tuberculosis strain from S family. The resazurin microtiter assay indicated that all isolates were resistant to isoniazid, ethambutol, ciprofloxacin, ofloxacin, streptomycin and amikacin...
June 30, 2016: Transboundary and Emerging Diseases
https://www.readbyqxmd.com/read/27298310/dogs-are-man-s-best-friend-in-sickness-and-in-health
#12
R Timothy Bentley, Atique U Ahmed, Amy B Yanke, Aaron A Cohen-Gadol, Mahua Dey
With the median survival of 14.6 months following best available standard of care, malignant gliomas (MGs) remain one of the biggest therapeutic challenges of the modern time. Although the last several decades have witnessed tremendous advancement in our understanding of MG and evolution of many successful preclinical therapeutic strategies, even the most successful preclinical therapeutic strategies often fail to cross the phase I/II clinical trial threshold. One of the significant, but less commonly discussed, barriers in developing effective glioma therapy is the lack of a robust preclinical model...
June 13, 2016: Neuro-oncology
https://www.readbyqxmd.com/read/27259025/intravenous-lipid-emulsion-therapy-for-bromethalin-toxicity-in-a-dog
#13
Brittany Heggem-Perry, Maureen McMichael, Mauria O'Brien, Clara Moran
Bromethalin is a central nervous system toxin currently incorporated into several different rodenticides. In 2008, the EPA requested that manufacturers phase out second-generation anticoagulant rodenticides. In response, manufacturers began to increase production of bromethalin-based rodenticides. It is likely that pet exposure to bromethalin will increase in the future. Bromethalin has no known antidote and tends to deposit in fat. Intravenous lipid emulsions (ILEs) are being used with increasing frequency in both human and veterinary medicine to treat numerous acute systemic toxicities...
July 2016: Journal of the American Animal Hospital Association
https://www.readbyqxmd.com/read/27259020/2016-aaha-oncology-guidelines-for-dogs-and-cats
#14
Barb Biller, John Berg, Laura Garrett, David Ruslander, Richard Wearing, Bonnie Abbott, Mithun Patel, Diana Smith, Christine Bryan
All companion animal practices will be presented with oncology cases on a regular basis, making diagnosis and treatment of cancer an essential part of comprehensive primary care. Because each oncology case is medically unique, these guidelines recommend a patient-specific approach consisting of the following components: diagnosis, staging, therapeutic intervention, provisions for patient and personnel safety in handling chemotherapy agents, referral to an oncology specialty practice when appropriate, and a strong emphasis on client support...
July 2016: Journal of the American Animal Hospital Association
https://www.readbyqxmd.com/read/27184522/animal-assisted-interventions-in-dutch-nursing-homes-a-survey
#15
Lonneke Schuurmans, Marie-Jose Enders-Slegers, Theo Verheggen, Jos Schols
OBJECTIVES: Animal-assisted interventions (AAI) have become more and more popular in nursing homes in the past decade. Various initiatives for using animals in nursing homes have been developed over the years (eg, animal visiting programs, residential companion animals, petting zoos) and, on the whole, the number of nursing homes that refuse animals on their premises has declined. In this survey, we aimed to determine how many Dutch nursing homes offer AAIs, what type of interventions are used, and with what aim...
July 1, 2016: Journal of the American Medical Directors Association
https://www.readbyqxmd.com/read/26909526/prior-antibacterial-drug-exposure-in-dogs-with-meticillin-resistant-staphylococcus-pseudintermedius-mrsp-pyoderma
#16
Nao Hensel, Sonja Zabel, Patrick Hensel
BACKGROUND: The emergence of meticillin-resistant Staphylococcus pseudintermedius (MRSP) has become a significant animal health problem. Recent studies have indicated that previous antibacterial drug exposure is a factor in acquisition of meticillin-resistant strains of staphylococci. HYPOTHESIS/OBJECTIVES: The purpose of this study was to identify factors associated with prior antimicrobial drug use and MRSP pyoderma in dogs presented to a veterinary teaching hospital...
April 2016: Veterinary Dermatology
https://www.readbyqxmd.com/read/26859850/in-vivo-evaluation-of-blood-based-and-reference-tissue-based-pet-quantifications-of-11c-dasb-in-the-canine-brain
#17
Nick Van Laeken, Olivia Taylor, Ingeborgh Polis, Sara Neyt, Ken Kersemans, Andre Dobbeleir, Jimmy Saunders, Ingeborg Goethals, Kathelijne Peremans, Filip De Vos
This first-in-dog study evaluates the use of the PET-radioligand [11C]DASB to image the density and availability of the serotonin transporter (SERT) in the canine brain. Imaging the serotonergic system could improve diagnosis and therapy of multiple canine behavioural disorders. Furthermore, as many similarities are reported between several human neuropsychiatric conditions and naturally occurring canine behavioural disorders, making this tracer available for use in dogs also provide researchers an interesting non-primate animal model to investigate human disorders...
2016: PloS One
https://www.readbyqxmd.com/read/26778055/bacteria-and-genetically-modified-bacteria-as-cancer-therapeutics-current-advances-and-challenges
#18
Shreeram C Nallar, De-Qi Xu, Dhan V Kalvakolanu
Bacteria act as pro- or anti- tumorigenic agents. Whole bacteria or cytotoxic or immunogenic peptides carried by them exert potent anti-tumor effects in the experimental models of cancer. The use of attenuated microorganism(s) e.g., BCG to treat human urinary bladder cancer was found to be superior compared to standard chemotherapy. Although the phase-I clinical trials with Salmonella enterica serovar Typhimurium, has shown limited benefits in human subjects, a recent pre-clinical trial in pet dogs with tumors reported some subjects benefited from this treatment strain...
January 2017: Cytokine
https://www.readbyqxmd.com/read/26758809/molecular-characterization-and-drug-susceptibility-profile-of-a-mycobacterium-avium-subspecies-avium-isolate-from-a-dog-with-disseminated-infection
#19
Federica Armas, Tommaso Furlanello, Cristina Camperio, Michele Trotta, Gianluca Novari, Cinzia Marianelli
Mycobacterium avium complex (MAC) infections have been described in many mammalian species including humans and pets. We isolated and molecularly typed the causative agent of a rare case of disseminated mycobacteriosis in a dog. We identified the pathogen as a M. avium subspecies avium by sequencing the partial genes gyrB and rpsA. Considering the zoonotic potential of this infection, and in an attempt to ensure the most effective treatment for the animal, we also determined the drug susceptibility profile of the isolate to the most common drugs used to treat MAC disease in humans...
January 12, 2016: Journal of Medical Microbiology
https://www.readbyqxmd.com/read/26388764/social-robots-in-advanced-dementia
#20
Meritxell Valentí Soler, Luis Agüera-Ortiz, Javier Olazarán Rodríguez, Carolina Mendoza Rebolledo, Almudena Pérez Muñoz, Irene Rodríguez Pérez, Emma Osa Ruiz, Ana Barrios Sánchez, Vanesa Herrero Cano, Laura Carrasco Chillón, Silvia Felipe Ruiz, Jorge López Alvarez, Beatriz León Salas, José M Cañas Plaza, Francisco Martín Rico, Gonzalo Abella Dago, Pablo Martínez Martín
AIMS: Pilot studies applying a humanoid robot (NAO), a pet robot (PARO) and a real animal (DOG) in therapy sessions of patients with dementia in a nursing home and a day care center. METHODS: In the nursing home, patients were assigned by living units, based on dementia severity, to one of the three parallel therapeutic arms to compare: CONTROL, PARO and NAO (Phase 1) and CONTROL, PARO, and DOG (Phase 2). In the day care center, all patients received therapy with NAO (Phase 1) and PARO (Phase 2)...
2015: Frontiers in Aging Neuroscience
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