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https://www.readbyqxmd.com/read/29732386/naturally-occurring-canine-invasive-urothelial-carcinoma-a-model-for-emerging-therapies
#1
REVIEW
Breann C Sommer, Deepika Dhawan, Timothy L Ratliff, Deborah W Knapp
The development of targeted therapies and the resurgence of immunotherapy offer enormous potential to dramatically improve the outlook for patients with invasive urothelial carcinoma (InvUC). Optimization of these therapies, however, is crucial as only a minority of patients achieve dramatic remission, and toxicities are common. With the complexities of the therapies, and the growing list of possible drug combinations to test, highly relevant animal models are needed to assess and select the most promising approaches to carry forward into human trials...
April 26, 2018: Bladder Cancer
https://www.readbyqxmd.com/read/29724584/stereotactic-body-radiation-therapy-for-heart-base-tumors-in-six-dogs
#2
L M Magestro, T L Gieger, M W Nolan
INTRODUCTION: Heart-base tumors are increasingly treated with radiotherapy, yet safety and efficacy are incompletely understood. This case series describes outcomes after stereotactic body radiation therapy (SBRT) for presumed chemodectoma. ANIMALS: Six pet dogs. METHODS: A retrospective study was performed, including dogs with a clinical diagnosis of chemodectoma and treatment with three-fraction SBRT (30 Gy total). RESULTS: Heart-base tumors, presumed or confirmed to be chemodectomas, were diagnosed via histopathology or imaging...
April 30, 2018: Journal of Veterinary Cardiology: the Official Journal of the European Society of Veterinary Cardiology
https://www.readbyqxmd.com/read/29721181/near-infrared-photoimmunotherapy-targeting-bladder-cancer-with-a-canine-anti-epidermal-growth-factor-receptor-egfr-antibody
#3
Tadanobu Nagaya, Shuhei Okuyama, Fusa Ogata, Yasuhiro Maruoka, Deborah W Knapp, Sophia N Karagiannis, Judit Fazekas-Singer, Peter L Choyke, Amy K LeBlanc, Erika Jensen-Jarolim, Hisataka Kobayashi
Anti-epidermal growth factor receptor (EGFR) antibody therapy is used in EGFR expressing cancers including lung, colon, head and neck, and bladder cancers, however results have been modest. Near infrared photoimmunotherapy (NIR-PIT) is a highly selective tumor treatment that employs an antibody-photo-absorber conjugate which is activated by NIR light. NIR-PIT is in clinical trials in patients with recurrent head and neck cancers using cetuximab-IR700 as the conjugate. However, its use has otherwise been restricted to mouse models...
April 10, 2018: Oncotarget
https://www.readbyqxmd.com/read/29704943/what-has-changed-in-canine-pyoderma-a-narrative-review
#4
REVIEW
A Loeffler, D H Lloyd
Canine pyoderma is a common presentation in small animal practice and frequently leads to prescription of systemic antimicrobial agents. A good foundation of knowledge on pyoderma was established during the 1970s and 1980s, when treatment of infection provided relatively few challenges. However, the ability to treat canine pyoderma effectively is now limited substantially by the emergence of multidrug-resistant, methicillin-resistant staphylococci (MRS) and, in some countries, by restrictions on antimicrobial prescribing for pets...
May 2018: Veterinary Journal
https://www.readbyqxmd.com/read/29659063/parents-acceptance-and-their-children-s-choice-of-pet-for-animal-assisted-therapy-a-a-t-in-3-to-12-year-old-children-in-the-dental-operatory-a-questionnaire-based-pilot-study
#5
Nidhi Gupta, Tushar Yadav
AIM: To evaluate the parents' acceptance to therapy pets, child's most favoured pet, child's choice of soft toy as compared to live pet, and child's preference of his own pet versus therapy pet. METHODS: Sixty-two children of age groups 3-6 year, 6-9 year, and 9-12 year were selected. The data from completed questionnaires were statistically analysed and subjected to z test, Chi-squared test with P value<0.05 considered as significant. RESULTS: The consent to the presence of pet was given by 41...
April 16, 2018: International Journal of Paediatric Dentistry
https://www.readbyqxmd.com/read/29606140/identification-of-immunologic-and-clinical-characteristics-that-predict-inflammatory-response-to-c-novyi-nt-bacteriolytic-immunotherapy
#6
Amy E DeClue, Sandra M Axiak-Bechtel, Yan Zhang, Saurabh Saha, Linping Zhang, David D Tung, Jeffrey N Bryan
BACKGROUND: Clostridium novyi-NT (CNV-NT), has shown promise as a bacterolytic therapy for solid tumors in mouse models and in dogs with naturally developing neoplasia. Factors that impact the immunologic response to therapy are largely unknown. The goal of this pilot study was to determine if plasma immune biomarkers, immune cell function, peripheral blood cytological composition and tumor characteristics including evaluation of a PET imaging surrogate of tumor tissue hypoxia could predict which dogs with naturally developing naïve neoplasia would develop an inflammatory response to CNV-NT...
April 2, 2018: BMC Veterinary Research
https://www.readbyqxmd.com/read/29594160/job-related-stress-in-forensic-interviewers-of-children-with-use-of-therapy-dogs-compared-with-facility-dogs-or-no-dogs
#7
Diane Walsh, Mariko Yamamoto, Neil H Willits, Lynette A Hart
Sexually abused children providing essential testimony regarding crimes in forensic interviews now sometimes are provided facility dogs or therapy dogs for comfort. Facility dogs are extensively trained to work with forensic interviewers; when using therapy dogs in interviews, volunteers are the dog handlers. Interviews can impact child welfare workers' mental health causing secondary traumatic stress (STS). To investigate this stress, first data were gathered on stress retrospectively for when interviewers initially started the job prior to working with a dog, and then currently, from forensic interviewers using a facility dog, a therapy or pet dog, or no dog...
2018: Frontiers in Veterinary Science
https://www.readbyqxmd.com/read/29528189/petting-away-pre-exam-stress-the-effect-of-therapy-dog-sessions-on-student-well-being
#8
Emma Ward-Griffin, Patrick Klaiber, Hanne K Collins, Rhea L Owens, Stanley Coren, Frances S Chen
Recently, many universities have implemented programmes in which therapy dogs and their handlers visit college campuses. Despite the immense popularity of therapy dog sessions, few randomized studies have empirically tested the efficacy of such programmes. The present study evaluates the efficacy of such a therapy dog programme in improving the well-being of university students. This research incorporates two components: (a) a pre/post within-subjects design, in which 246 participants completed a brief questionnaire immediately before and after a therapy dog session and (b) an experimental design with a delayed-treatment control group, in which all participants completed baseline measures and follow-up measures approximately 10 hr later...
March 12, 2018: Stress and Health: Journal of the International Society for the Investigation of Stress
https://www.readbyqxmd.com/read/29503767/pharmacokinetics-and-safety-of-oral-glyburide-in-dogs-with-acute-spinal-cord-injury
#9
Nick Jeffery, C Elizabeth Boudreau, Megan Konarik, Travis Mays, Virginia Fajt
Background: Glyburide (also known as glibenclamide) is effective in reducing the severity of tissue destruction and improving functional outcome after experimental spinal cord injury in rodents and so has promise as a therapy in humans. There are many important differences between spinal cord injury in experimental animals and in human clinical cases, making it difficult to introduce new therapies into clinical practice. Spinal cord injury is also common in pet dogs and requires new effective therapies, meaning that they can act as a translational model for the human condition while also deriving direct benefits from such research...
2018: PeerJ
https://www.readbyqxmd.com/read/29459862/immunotherapy-for-dogs-running-behind-humans
#10
REVIEW
Hans Klingemann
A number of excellent reviews on the potential of canine cancer immunotherapy are available, but many extrapolate from observations in humans when in fact only very few immunotherapies have been developed for canines that have shown efficacy in well-designed studies. Pharmaceutical and biotech companies are aware that the market for more expensive immunotherapies in canines is limited resulting in limited funding for clinical trials. However, dogs and other pets deserve access to this new form of cancer therapy...
2018: Frontiers in Immunology
https://www.readbyqxmd.com/read/29411550/dog-and-cat-allergies-current-state-of-diagnostic-approaches-and-challenges
#11
REVIEW
Sanny K Chan, Donald Y M Leung
Allergies to dogs and cats affect 10%-20% of the population worldwide and is a growing public health concern as these rates increase. Given the prevalence of detectable dog and cat allergens even in households without pets, there is a critical need to accurately diagnose and treat patients to reduce morbidity and mortality from exposure. The ability to diagnose cat sensitization is good, in contrast to dogs. Component resolved diagnostics of sensitization to individual allergenic proteins will dramatically improve diagnosis...
March 2018: Allergy, Asthma & Immunology Research
https://www.readbyqxmd.com/read/29378221/canine-sarcomas-as-a-surrogate-for-the-human-disease
#12
REVIEW
Daniel L Gustafson, Dawn L Duval, Daniel P Regan, Douglas H Thamm
Pet dogs are becoming increasingly recognized as a population with the potential to inform medical research through their treatment for a variety of maladies by veterinary health professionals. This is the basis of the One Health initiative, supporting the idea of collaboration between human and animal health researchers and clinicians to study spontaneous disease processes and treatment in animals to inform human health. Cancer is a major health burden in pet dogs, accounting for approximately 30% of deaths across breeds...
March 9, 2018: Pharmacology & Therapeutics
https://www.readbyqxmd.com/read/29218302/canine-soft-tissue-sarcomas-can-being-a-dog-s-best-friend-help-a-child
#13
Bernard Séguin
Soft tissue sarcomas (STSs) remain a therapeutic challenge for pediatric and adolescent and young adult (AYA) patients. Still today, surgery, radiation therapy, and chemotherapy remain the mainstay of treatment. Obstacles in developing new treatment approaches to improve the outcome are: few patients to enroll in clinical trials, and the diversity of tumor biology between histologic subtypes. Pet dogs may offer an additional strategy to discover and test new therapeutic avenues. The number of dogs diagnosed with a STS each year in the United States is estimated to be around 27,000 to 95,000...
2017: Frontiers in Oncology
https://www.readbyqxmd.com/read/29207604/canis-familiaris-allergen-can-f-6-expression-purification-and-analysis-of-b-cell-epitopes-in-chinese-dog-allergic-children
#14
Yu-Jie Wang, Lin Li, Wei-Juan Song, Yan-Jun Zhou, Meng-Da Cao, Xiang-Rong Zuo, Ji-Fu Wei
Dog allergy is common worldwide. However, the allergenicity of dog allergy is still unclear in China as well as in special group, such as children. In this study, we chose Can f 6, a major dog allergen which belongs to the lipocalin to study its allergenicity in Chinese dog allergic children. Can f 6 gene was subcloned into pET-28a vector and transformed into E. coli BL21 (DE3) cells for expression. The recombinant Can f 6 was purified by nickel affinity chromatography, identified by SDS-PAGE, and tested for its allergenicity by Western blot with sera and basophil activation test...
October 31, 2017: Oncotarget
https://www.readbyqxmd.com/read/29173160/simple-and-fast-gas-chromatography-mass-spectrometry-assay-to-assess-delta-9-tetrahydrocannabinol-and-cannabidiol-in-dogs-treated-with-medical-cannabis-for-canine-epilepsy
#15
Maria C Rotolo, Silvia Graziano, Manuela Pellegrini, Daniele Corlazzoli, Lucia Antinori, Laura Porcarelli, Simona Pichini
BACKGROUND: To date, an increasing number of pet owners, especially in the USA, are using cannabis-derived products containing generally delta 9-tetrahydrocannabinol (THC) and cannabidiol (CBD) to help their animals' health. Unfortunately, studies on the clinical use of cannabinoids in veterinary medicine are still limited, and the application of analytical methodologies for the determination of cannabinoids in animal (especially dog) biological matrices such as plasma, is still missing...
2017: Current Pharmaceutical Biotechnology
https://www.readbyqxmd.com/read/29158470/comparative-oncology-evaluation-of-intravenous-recombinant-oncolytic-vesicular-stomatitis-virus-therapy-in-spontaneous-canine-cancer
#16
Shruthi Naik, Gina D Galyon, Nathan J Jenks, Michael B Steele, Amber C Miller, Sara D Allstadt, Lukkana Suksanpaisan, Kah Whye Peng, Mark J Federspiel, Stephen J Russell, Amy K LeBlanc
Clinical translation of intravenous therapies to treat disseminated or metastatic cancer is imperative. Comparative oncology, the evaluation of novel cancer therapies in animals with spontaneous cancer, can be utilized to inform and accelerate clinical translation. Preclinical murine studies demonstrate that single-shot systemic therapy with a vesicular stomatitis virus (VSV)-IFNβ-NIS, a novel recombinant oncolytic VSV, can induce curative remission in tumor-bearing mice. Clinical translation of VSV-IFNβ-NIS therapy is dependent on comprehensive assessment of clinical toxicities, virus shedding, pharmacokinetics, and efficacy in clinically relevant models...
January 2018: Molecular Cancer Therapeutics
https://www.readbyqxmd.com/read/29143646/validation-of-immune-complex-dissociation-methods-for-use-with-heartworm-antigen-tests
#17
Melissa J Beall, Andrea Arguello-Marin, Jan Drexel, Jiayou Liu, Ramaswamy Chandrashekar, A Rick Alleman
BACKGROUND: Antigen testing is routinely used to diagnose canine Dirofilaria immitis infections. Immune complex dissociation (ICD) methods, which were employed in the original heartworm antigen tests to release antigen that was bound by endogenous canine antibodies, were discontinued with improvements in assay reagents. The purpose of this study was to evaluate different ICD methods for detection of heartworm antigen by microtiter plate ELISA and assess the performance in samples from pet dogs...
November 9, 2017: Parasites & Vectors
https://www.readbyqxmd.com/read/29117933/a-web-based-study-of-dog-ownership-and-depression-among-people-living-with-hiv
#18
Abigail L Muldoon, Lisa M Kuhns, Julie Supple, Kristen C Jacobson, Robert Garofalo
BACKGROUND: People living with human immunodeficiency virus (PLHIV) are approximately twice as likely to be depressed compared with HIV-negative individuals. Depression is consistently associated with low antiretroviral therapy (ART) adherence, an important step within the HIV care continuum related to HIV disease progression and overall health. One factor that may have positive psychosocial benefits and promote ART adherence is dog ownership. Research indicates that dog ownership is associated with lower depression, and initial evidence suggests its positive impact on psychosocial outcomes for PLHIV...
November 8, 2017: JMIR Mental Health
https://www.readbyqxmd.com/read/29113289/synergistic-and-targeted-therapy-with-a-procaspase-3-activator-and-temozolomide-extends-survival-in-glioma-rodent-models-and-is-feasible-for-the-treatment-of-canine-malignant-glioma-patients
#19
Avadhut D Joshi, Rachel C Botham, Lisa J Schlein, Howard S Roth, Antonella Mangraviti, Alexandra Borodovsky, Betty Tyler, Steve Joslyn, Jayme S Looper, Michael Podell, Timothy M Fan, Paul J Hergenrother, Gregory J Riggins
Purpose: Glioblastoma is a deadly brain cancer with a median survival time of ∼15 months. Ionizing radiation plus the DNA alkylator temozolomide (TMZ) is the current standard therapy. PAC-1, a procaspase-3 activating small molecule, is blood-brain barrier penetrant and has previously demonstrated ability to synergize with diverse pro-apoptotic chemotherapeutics. We studied if PAC-1 could enhance the activity of TMZ, and whether addition of PAC-1 to standard treatment would be feasible in spontaneous canine malignant gliomas...
October 6, 2017: Oncotarget
https://www.readbyqxmd.com/read/29077073/the-biology-and-ecology-of-cat-fleas-and-advancements-in-their-pest-management-a-review
#20
REVIEW
Michael K Rust
The cat flea Ctenocephalides felis felis (Bouché) is the most important ectoparasite of domestic cats and dogs worldwide. It has been two decades since the last comprehensive review concerning the biology and ecology of C. f. felis and its management. Since then there have been major advances in our understanding of the diseases associated with C. f. felis and their implications for humans and their pets. Two rickettsial diseases, flea-borne spotted fever and murine typhus, have been identified in domestic animal populations and cat fleas...
October 27, 2017: Insects
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