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https://www.readbyqxmd.com/read/29028858/approach-to-the-mature-cosmetic-patient-aging-gracefully
#1
Susan Weinkle, Michael Saco
<p>Aging gracefully has taken on a whole new meaning over the past few decades as new aesthetic treatments have been developed and are becoming more sophisticated by the day. The aging process, which is exacerbated by chronic UV exposure, results in dyspigmentation, loss of skin laxity, precancerous and cancerous skin lesions, fat loss and redistribution, and bone resorption. Laser and light devices can be used to treat dyspigmentation, while neuromodulators and soft tissue fillers can be used for rhytides and revolumization...
June 1, 2017: Journal of Drugs in Dermatology: JDD
https://www.readbyqxmd.com/read/29027984/the-effect-of-intra-articular-injection-of-autologous-microfragmented-fat-tissue-on-proteoglycan-synthesis-in-patients-with-knee-osteoarthritis
#2
Damir Hudetz, Igor Borić, Eduard Rod, Željko Jeleč, Andrej Radić, Trpimir Vrdoljak, Andrea Skelin, Gordan Lauc, Irena Trbojević-Akmačić, Mihovil Plečko, Ozren Polašek, Dragan Primorac
Osteoarthritis (OA) is one of the leading musculoskeletal disorders in the adult population. It is associated with cartilage damage triggered by the deterioration of the extracellular matrix tissue. The present study explores the effect of intra-articular injection of autologous microfragmented adipose tissue to host chondrocytes and cartilage proteoglycans in patients with knee OA. A prospective, non-randomized, interventional, single-center, open-label clinical trial was conducted from January 2016 to April 2017...
October 13, 2017: Genes
https://www.readbyqxmd.com/read/29026830/treatment-of-constriction-bands-of-limbs-by-fat-injection-an-additional-modality
#3
Mahendra Daya
BACKGROUND: Constriction bands in the majority of cases presents as a contour deformity. The gold standard of treatment is a single-stage constriction ring excision and serial Z-plasty. The expense is unsightly scarring. We present case reports of deformity correction by serial fat injections. METHODS AND PARTICIPANTS: Three case studies of children in whom this modality was used in limbs to correct the deformity are presented. RESULTS: Two participants showed a good correction of the deformity and in a single-case treatment failed requiring excision and serial Z-plasty for correction...
August 2017: Plastic Surgery
https://www.readbyqxmd.com/read/29025218/regenerative-cells-for-facial-surgery-biofilling-and-biocontouring
#4
Steven R Cohen, Sierra Hewett, Lauren Ross, Flore Delaunay, Ashley Goodacre, Char Ramos, Tracy Leong, Ahmad Saad
Zuk et al in 2001 identified stem and regenerative cells within the stromal vascular fraction of fat. In preclinical studies, these cells appeared to stimulate angiogenesis and reduce inflammation, and soon thereafter, clinical use of stromal vascular fraction (SVF) evolved as researchers such as Rigotti, Coleman, Mojallal, our group, and others demonstrated that fat can be used for both therapeutic and aesthetic indications. The regenerative effects of fat and its contents on facial aesthetics have been shown at the histologic and cellular level...
July 1, 2017: Aesthetic Surgery Journal
https://www.readbyqxmd.com/read/29024899/mangiferin-ameliorates-fatty-liver-via-modulation-of-autophagy-and-inflammation-in-high-fat-diet-induced-mice
#5
Hu Wang, Yang-Yang Zhu, Li Wang, Tian Teng, Meng Zhou, Shu-Guang Wang, Yi-Zhu Tian, Lei Du, Xiao-Xing Yin, Ying Sun
Non-alcoholic fatty liver disease (NAFLD) is the most common liver disease globally. The progression of NAFLD is complex and associated with inflammation, oxidative stress, autophagy, endoplasmic reticulum stress, and insulin resistance. Mangiferin, a natural C-glucosyl xanthone, has been reported to show multiple biological activities. The aim of this study was to investigate the therapeutic effect of mangiferin on NAFLD and the underlying molecular mechanism. We established a mouse model of NAFLD using a high-fat diet (HFD), and injected the mice with different doses of mangiferin (15, 30, and 60mg/kg, intraperitoneal) for 12 weeks...
October 9, 2017: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/29021697/chronic-saponin-treatment-attenuates-damage-to-the-pancreas-in-chronic-alcohol-treated-diabetic-rats
#6
Mi Ran Choi, Su Min Kwak, Sol Hee Bang, Jo-Eun Jeong, Dai-Jin Kim
BACKGROUND: Chronic heavy alcohol consumption may raise the risk of developing type 2 diabetes mellitus. Saponins inhibit apoptosis of pancreatic islet cells and reduce lipid parameters. The present study was designed to investigate the effect of saponin on chronic ethanol-treated diabetic rats. METHODS: Long-Evans Tokushima Fatty (LETO) and Otsuka Long-Evans Tokushima Fatty (OLETF) rats were pair-fed a Lieber-DeCarli diet with and without 5% ethanol for 12 wks...
October 2017: Journal of Ginseng Research
https://www.readbyqxmd.com/read/29017855/role-of-neuromedin-u-in-accelerating-of-non-alcoholic-steatohepatitis-in-mice
#7
Hitoshi Teranishi, Masafumi Hayashi, Ryoko Higa, Kenji Mori, Takashi Miyazawa, Jun Hino, Yuichiro Amano, Ryuichi Tozawa, Takanori Ida, Toshikatsu Hanada, Mikiya Miyazato, Reiko Hanada, Kenji Kangawa, Kazuwa Nakao
Neuromedin U (NMU), a neuropeptide originally isolated from porcine spinal cord, has multiple physiological functions and is involved in obesity and inflammation. Excessive fat accumulation in the liver leads to non-alcoholic fatty liver disease (NAFLD) and non-alcoholic steatohepatitis (NASH), which is closely associated with obesity. NAFLD and NASH develop and progress via complex pathophysiological processes, and it remains unclear to what extend the NMU system contributes to the risk of obesity-related disorders such as NAFLD and NASH...
October 7, 2017: Peptides
https://www.readbyqxmd.com/read/28994540/-protective-effect-of-shuyu-yiban-decoction-on-atherosclerosis-in-rats-induced-by-chronic-unpredictable-mild-stress
#8
Xiao-Jun Zheng, Zhi-Qiang Hu, Shu-Wei Luan, Ran Li, Yun Li, Jian-Liang Li, Yu-Jie Li, Xiao-Xin Zhu
Shuyu Yiban decoction(SYYB) has significant effect in treating the patients with coronary heart disease combined with chronic psychological stress. In this study, in order to observe the effects of SYYB on early formation of atherosclerosis(As) and inflammation response induced by chronic psychological stress, high-fat diet+intraperitoneal injections of Vitamin D3 were given to establish As early lesion models, and based on these models, chronic unpredictable mild stress(CUMS) was used to observe whether the chronic psychological stress could increase coronary atherosclerotic lesions investigate the intervention effect of SYYB(6...
March 2017: Zhongguo Zhong Yao za Zhi, Zhongguo Zhongyao Zazhi, China Journal of Chinese Materia Medica
https://www.readbyqxmd.com/read/28990215/ultrasonic-perfluorohexane-loaded-monocyte-imaging-toward-a-minimally-invasive-technique-for-selective-detection-of-liver-inflammation-in-fatty-liver-disease
#9
Koen D Reesink, Tim Hendrikx, Patrick J van Gorp, Arnold P Hoeks, Ronit Shiri-Sverdlov
OBJECTIVES: To investigate the utility of ultrasonic (US) perfluorohexane (PFH)-loaded monocyte imaging for detection of liver inflammation in fatty liver disease. METHODS: C57Bl6 mice were injected intraperitoneally with tumor necrosis factor α and assessed by US PFH-loaded monocyte imaging 3 hours later. Echogenic monocytes were injected intravenously, leading to a transient increase in liver tissue intensity on a US perfusion scan. The contrast wash-out time constant was hypothesized to reflect the degree of inflammation...
October 9, 2017: Journal of Ultrasound in Medicine: Official Journal of the American Institute of Ultrasound in Medicine
https://www.readbyqxmd.com/read/28989238/hand-rejuvenation-with-fat-grafting-a-12-year-single-surgeon-experience
#10
Fabio Fantozzi
BACKGROUND: Fat grafting has been successfully used for reconstructive and esthetic surgery of the breast, face, and other body parts. In this article, we present our protocol for hand fat grafting and over a decade of clinical experience. METHODS: Fat tissue is obtained from the flanks, peri-umbilical region, or internal side of the thigh or knee. No centrifuge machine is used to prevent fat damage. After decantation, fat is injected into the dorsum of the hand using a cannula from the wrist and not from the fingers...
2017: European Journal of Plastic Surgery
https://www.readbyqxmd.com/read/28986671/transcervical-fat-injection-laryngoplasty-for-unilateral-vocal-fold-paralysis-an-easy-way-to-do-the-job
#11
Hisham E M Elbadan, Wael K A Hussein, Riham M Elmaghraby
Unilateral vocal fold paralysis resulting in glottic incompetence can cause impairment of laryngeal functions, including airway protection and phonation. The objective of this study is to present an easy new technique for harvesting and injection of abdominal fat into the vocal fold for patients with unilateral vocal fold paralysis. This is a retrospective study of patients carried out on 16 patients suffering from unilateral vocal fold paralysis resulting from different etiologies. All patients were subjected to the protocol of voice assessment pre- and postoperatively...
October 6, 2017: European Archives of Oto-rhino-laryngology
https://www.readbyqxmd.com/read/28984813/dual-isotope-subtraction-spect-ct-in-parathyroid-localization
#12
Anna-May Woods, Alison A Bolster, Sai Han, Fat-Wui Poon, David Colville, John Shand, James B Neilly
OBJECTIVE: The aim of this study was to investigate the accuracy of locating parathyroid adenomas using dual-Isotope subtraction single-photon emission computed tomography-computed tomography (SPECT-CT) in comparison with clinical follow-up and pathology findings from surgery. PATIENTS AND METHODS: A retrospective cohort study of dual-isotope subtraction SPECT-CT was carried out on 224 consecutive patients who were diagnosed with primary hyperparathyroidism. All the patients were injected with 20 MBq of iodine-123-iodide, followed 20 min later by 900 MBq of technetium-99m-sestamibi...
October 3, 2017: Nuclear Medicine Communications
https://www.readbyqxmd.com/read/28983743/pet-imaging-of-human-brown-adipose-tissue-with-the-tspo-tracer-11-c-pbr28
#13
Chongzhao Ran, Daniel S Albrecht, Miriam A Bredella, Jing Yang, Jian Yang, Steven H Liang, Aaron M Cypess, Marco L Loggia, Nazem Atassi, Anna Moore
PURPOSE: Brown adipose tissue (BAT) in adult humans has been recently rediscovered and intensively investigated as a new potential therapeutic target for obesity and type 2 diabetes (T2D). However, reliable assessment of BAT mass in vivo represents a considerable challenge. The purpose of this investigation is to demonstrate for the first time that human BAT depots can be imaged with a translocator protein (TSPO)-specific positron emission tomography (PET) tracer [(11)C]PBR28 under thermoneutral conditions...
October 5, 2017: Molecular Imaging and Biology: MIB: the Official Publication of the Academy of Molecular Imaging
https://www.readbyqxmd.com/read/28983592/amygdalin-ameliorates-the-progression-of-atherosclerosis-in-ldl-receptor%C3%A2-deficient-mice
#14
Jianzhen Lv, Wen Xiong, Tiantian Lei, Hailian Wang, Minghan Sun, Erwei Hao, Zhiping Wang, Xiaoqi Huang, Shaoping Deng, Jiagang Deng, Yi Wang
Previous studies have demonstrated that regulatory T cells (Tregs) are pivotal in the regulation of T cell‑mediated immune responses in atherosclerosis, a chronic autoimmune‑like disease. In the authors' previous studies, it was demonstrated that amygdalin ameliorated atherosclerosis by the regulation of Tregs in apolipoprotein E‑deficient (ApoE‑/‑) mice. Therefore, the aim of the present study was to investigate the therapeutic effect of amygdalin on low‑density lipoprotein (LDL) receptor deficient (LDLR‑/‑) mice, and to examine its immune regulatory function by the stimulation of Tregs...
September 25, 2017: Molecular Medicine Reports
https://www.readbyqxmd.com/read/28980212/injectable-facial-fillers-imaging-features-complications-and-diagnostic-pitfalls-at-mri-and-pet-ct
#15
REVIEW
Pravin Mundada, Romain Kohler, Sana Boudabbous, Laurence Toutous Trellu, Alexandra Platon, Minerva Becker
Injectable fillers are widely used for facial rejuvenation, correction of disabling volumetric fat loss in HIV-associated facial lipoatrophy, Romberg disease, and post-traumatic facial disfiguring. The purpose of this article is to acquaint the reader with the anatomy of facial fat compartments, as well as with the properties and key imaging features of commonly used facial fillers, filler-related complications, interpretation pitfalls, and dermatologic conditions mimicking filler-related complications. The distribution of facial fillers is characteristic and depends on the anatomy of the superficial fat compartments...
October 4, 2017: Insights Into Imaging
https://www.readbyqxmd.com/read/28979850/mesenchymal-stem-cells-for-cartilage-regeneration-in-osteoarthritis
#16
REVIEW
Baldur Kristjánsson, Sittisak Honsawek
Osteoarthritis (OA) is a slowly progressive disease where cartilage of the synovial joint degenerates. It is most common in the elderly where patients experience pain and reduce physical activity. In combination with lack of conventional treatment, patients are often left with no other choices than arthroplasty. Over the last years, multipotent stromal cells have been used in efforts to treat OA. Mesenchymal stem/progenitor cells (MSCs) are stromal cells that can differentiate into bone, fat, and cartilage cells...
September 18, 2017: World Journal of Orthopedics
https://www.readbyqxmd.com/read/28979814/breast-cancer-pulmonary-metastasis-is-increased-in-mice-undertaking-spontaneous-physical-training-in-the-running-wheel-a-call-for-revising-beneficial-effects-of-exercise-on-cancer-progression
#17
Marta Smeda, Kamil Przyborowski, Bartosz Proniewski, Agnieszka Zakrzewska, Dawid Kaczor, Marta Stojak, Elzbieta Buczek, Zenon Nieckarz, Jerzy A Zoladz, Joanna Wietrzyk, Stefan Chlopicki
It has been repeatedly shown that regular aerobic exercise exerts beneficial effects on incidence and progression of cancer. However, the data regarding effects of exercise on metastatic dissemination remain conflicting. Therefore, in the present study the possible preventive effects of voluntary wheel running on primary tumor growth and metastases formation in the model of spontaneous pulmonary metastasis were analyzed after orthotopic injection of 4T1 breast cancer cells into mammary fat pads of female Balb/C mice...
2017: American Journal of Cancer Research
https://www.readbyqxmd.com/read/28977868/thioredoxin-plays-a-key-role-in-retinal-neuropathy-prior-to-endothelial-damage-in-diabetic-mice
#18
Xiang Ren, Chen Li, Junli Liu, Chenghong Zhang, Yuzhen Fu, Nina Wang, Haiying Ma, Heyuan Lu, Hui Kong, Li Kong
Diabetes is a chronic metabolic syndrome that results in changes in carbohydrate, lipid and protein metabolism. With diabetes for a long time, it increases the risk of diabetic retinopathy (DR) and long-term morbidity and mortality. Moreover, emerging evidence suggests that neuron damage occurs earlier than microvascular complications in DR patients, but the underlying mechanism is unclear. We investigated diabetes-induced retinal neuropathy and elucidated key molecular events to identify new therapeutic targets for the clinical treatment and prevention of DR...
September 22, 2017: Oncotarget
https://www.readbyqxmd.com/read/28977588/hexarelin-a-growth-hormone-secretagogue-improves-lipid-metabolic-aberrations-in-nonobese-insulin-resistant-male-mkr-mice
#19
Rasha Mosa, Lili Huang, Yeda Wu, Chungyan Fung, Oshini Mallawakankanamalage, Derek LeRoith, Chen Chen
Despite the occurrence of dyslipidemia and its contribution to the development of insulin resistance in obese subjects, a growing number of studies have described abnormal lipid profiles among leaner persons. For example, individuals with an abnormal paucity or distribution of fat (lipodystrophy) develop severe insulin resistance, dyslipidemia, and hepatic steatosis. Deranged adipocyte metabolism and differentiation contribute to ectopic fat deposition and consequent development of insulin resistance. Growth hormone (GH) therapy has been shown to correct body composition abnormalities in some lipodystrophy patients...
October 1, 2017: Endocrinology
https://www.readbyqxmd.com/read/28975615/resistance-and-tolerance-the-role-of-nutrients-on-pathogen-dynamics-and-infection-outcomes-in-an-insect-host
#20
C V L Miller, S C Cotter
1.Tolerance and resistance are the two ways in which hosts can lessen the effects of infection. Tolerance aims to minimise the fitness effects resulting from incumbent pathogen populations, whereas resistance aims to reduce the pathogen population size within the host. While environmental impacts on resistance have been extensively recorded their impacts on variation in tolerance are virtually unexplored. 2.Here we ask how the environment, namely the host diet, influences the capacity of an organism to tolerate and resist infection, using a model host-parasite system, the burying beetle, Nicrophorus vespilloides and the entomopathogenic bacteria, Photorhabdus luminescens...
October 4, 2017: Journal of Animal Ecology
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