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https://www.readbyqxmd.com/read/29915227/microrna-214-promotes-hepatic-stellate-cell-activation-and-liver-fibrosis-by-suppressing-sufu-expression
#1
Liping Ma, Xiaoxue Yang, Rong Wei, Tinghong Ye, Jian-Kang Zhou, Maoyao Wen, Ruoting Men, Ping Li, Biao Dong, Lunxu Liu, Xianghui Fu, Heng Xu, Rami I Aqeilan, Yu-Quan Wei, Li Yang, Yong Peng
MicroRNAs (miRNAs) have been demonstrated to modulate cellular processes in the liver. However, the role of miRNAs in liver fibrosis is poorly understood. Because the activation of hepatic stellate cells (HSCs) is a pivotal event in the initiation and progression of hepatic fibrosis, we investigate the differential expression of miRNAs in activated and quiescent rat HSCs by microarray analysis and find that miR-214 (miR-214-3p) is significantly upregulated during HSC activation. Moreover, the robust induction of miR-214 is correlated with liver fibrogenesis in carbon tetrachloride (CCl4 )-treated rats and mice, high-fat diet-induced non-alcoholic steatohepatitis in mice, and cirrhosis in humans...
June 18, 2018: Cell Death & Disease
https://www.readbyqxmd.com/read/29911577/the-dynamics-of-the-pain-system-is-intact-in-patients-with-knee-osteoarthritis-an-exploratory-experimental-study
#2
Tanja Schjødt Jørgensen, Marius Henriksen, Sara Rosager, Louise Klokker, Karen Ellegaard, Bente Danneskiold-Samsøe, Henning Bliddal, Thomas Graven-Nielsen
Background and aims Despite the high prevalence of knee osteoarthritis (OA) it remains one of the most frequent knee disorders without a cure. Pain and disability are prominent clinical features of knee OA. Knee OA pain is typically localized but can also be referred to the thigh or lower leg. Widespread hyperalgesia has been found in knee OA patients. In addition, patients with hyperalgesia in the OA knee joint show increased pain summation scores upon repetitive stimulation of the OA knee suggesting the involvement of facilitated central mechanisms in knee OA...
December 29, 2017: Scandinavian Journal of Pain
https://www.readbyqxmd.com/read/29909574/the-possible-antidiabetic-effects-of-vitamin-d-receptors-agonist-in-rat-model-of-type-2-diabetes
#3
Wafaa M Abdel-Rehim, Rasha A El-Tahan, Mennatullah A El-Tarawy, Rowaida R Shehata, Maher A Kamel
Vitamin D3 deficiency was found to be tightly linked to many health problems including metabolic syndrome, cancer, cardiovascular diseases, and type 2 diabetes mellitus. In our study, we tested the possible antidiabetic effects of one of vitamin D3 analogs, alfacalcidol, solely or in a combination with metformin on type 2 diabetic rats. Type 2 diabetic model rats were induced by feeding high-fat diet for 4 weeks followed by intraperitoneal injection of streptozotocin. In addition to the control group, the diabetic rats were divided into four groups: untreated, metformin-treated, alfacalcidol-treated, and combination-treated group (metformin + alfacalcidol) for 4 weeks...
June 16, 2018: Molecular and Cellular Biochemistry
https://www.readbyqxmd.com/read/29909020/diet-modifies-colonic-microbiota-and-cd4-t-cell-repertoire-to-induce-flares-of-colitis-in-mice-with-myeloid-cell-expression-of-interleukin-23
#4
Lili Chen, Zhengxiang He, Alina Cornelia Iuga, Sebastião N Martins Filho, Jeremiah J Faith, Jose C Clemente, Madhura Deshpande, Anitha Jayaprakash, Jean-Frederic Colombel, Juan J Lafaille, Ravi Sachidanandam, Glaucia C Furtado, Sergio A Lira
BACKGROUND & AIMS: Several studies have shown that signaling via the interleukin 23 (IL23) receptor is required for development of colitis. We studied the roles of IL23, dietary factors, alterations to the microbiota, and T cells in development and progression of colitis in mice. METHODS: All mice were maintained on lab diet 5053, unless otherwise noted. We generated mice that express IL23 in CX3CR1-positive myeloid cells (R23FR mice) upon cyclic administration of tamoxifen dissolved in diet 2019...
June 14, 2018: Gastroenterology
https://www.readbyqxmd.com/read/29908701/direct-analysis-of-vitamin-a-vitamin-e-carotenoids-chlorophylls-and-free-sterols-in-animal-and-vegetable-fats-in-a-single-normal-phase-liquid-chromatographic-run
#5
Rebeca Cruz, Susana Casal
The present method was optimized and validated to enable quantification of more than twenty compounds from four chemical classes of important lipid substances, including vitamin E and A derivatives, sterols and chlorophylls. After lipid dissolution in the mobile phase, chromatographic separation is accomplished with the newest generation of ultrapure unbounded fully porous silica particles and, finally, target analytes are quantified by diode-array tandem fluorescence detection. A broad working range was achieved for most compounds (r2 > 0...
June 12, 2018: Journal of Chromatography. A
https://www.readbyqxmd.com/read/29908010/rapamycin-improves-insulin-resistance-and-hepatic-steatosis-in-type-2-diabetes-rats-through-activation-of-autophagy
#6
Wan Zhou, Shandong Ye
Insulin resistance (IR) is a hallmark of type 2 diabetes mellitus (T2DM). This study aimed to explore the effects of rapamycin, a specific inhibitor of kinase mammalian target of rapamycin (mTOR), on IR in T2DM rats, and to validate whether the underlying mechanism was associated with autophagy. In this study, the model of T2DM rats was established by feeding the animals with a high-fat diet (HFD) and intraperitoneal injection of streptozotocin (STZ). Diabetic rats were randomly divided into model of T2DM control group (DM-C, n=15), metformin group (DM-M, n=15), rapamycin group (DM-Rapa, n=15), 3-methyladenine (3-MA) group (DM-3-MA, n=15), and rapamycin+3-MA group (DM-Rapa-3-MA, n=15)...
June 16, 2018: Cell Biology International
https://www.readbyqxmd.com/read/29905790/characterization-of-the-tissue-and-stromal-cell-components-of-micro-superficial-enhanced-fluid-fat-injection-micro-seffi-for-facial-aging-treatment
#7
Martina Rossi, Barbara Roda, Silvia Zia, Ilaria Vigliotta, Chiara Zannini, Francesco Alviano, Laura Bonsi, Andrea Zattoni, Pierluigi Reschiglian, Alessandro Gennai
Background: New microfat preparations provide material suitable for use as a regenerative filler for different facial areas. To support the development of new robust techniques for regenerative purposes, the cellular content of the sample should be considered. Objectives: To evaluate the stromal vascular fraction (SVF) cell components of micro-superficial enhanced fluid fat injection (SEFFI) samples via a technique to harvest re-injectable tissue with minimum manipulation...
June 14, 2018: Aesthetic Surgery Journal
https://www.readbyqxmd.com/read/29900170/the-stromal-vascular-fraction-from-fat-tissue-in-the-treatment-of-osteochondral-knee-defect-case-report
#8
Ramil Z Salikhov, Ruslan F Masgutov, Mikhail A Chekunov, Leysan G Tazetdinova, Galina Masgutova, Oleg V Teplov, Damir Galimov, Yuri Plakseichuk, Ramil Yagudin, Igor O Pankov, Albert Rizvanov
In this study we applied autologous fat tissue stromal vascular fraction (SVF) cells in combination with microfracturing technique in a 36-year-old man with an osteochondral lesion of the medial femoral condyle 8 months after the injury. Cell material was generated by fat tissue liposuction from the anterior abdominal wall with subsequent extraction of the SVF and injected through a mini-arthrotomy portal with subsequent fibrin sealant fixation. The follow-up period was 2 years. Clinical score improved from 23 to 96 according to IKDC and from 10 to 90 according to EQ-VAS at 24 months follow-up...
2018: Frontiers in Medicine
https://www.readbyqxmd.com/read/29899400/hepatobiliary-mri-signal-intensity-based-assessment-of-liver-function-correlated-to-13-c-methacetin-breath-test
#9
Michael Haimerl, Ute Probst, Stefanie Poelsterl, Lukas Beyer, Claudia Fellner, Michael Selgrad, Matthias Hornung, Christian Stroszczynski, Philipp Wiggermann
Gadoxetic acid (Gd-EOB-DTPA) is a paramagnetic MRI contrast agent with raising popularity and has been used for evaluation of imaging-based liver function in recent years. In order to verify whether liver function as determined by real-time breath analysis using the intravenous administration of 13 C-methacetin can be estimated quantitatively from Gd-EOB-DTPA-enhanced MRI using signal intensity (SI) values. 110 patients underwent Gd-EOB-DTPA-enhanced 3-T MRI and, for the evaluation of liver function, a 13 C-methacetin breath test (13 C-MBT)...
June 13, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29896652/multispectral-optoacoustic-tomography-of-brown-adipose-tissue
#10
Angelos Karlas, Josefine Reber, Evangelos Liapis, Korbinian Paul-Yuan, Vasilis Ntziachristos
MSOT has revolutionized biomedical imaging because it allows anatomical, functional, and molecular imaging of deep tissues in vivo in an entirely noninvasive, label-free, and real-time manner. This imaging modality works by pulsing light onto tissue, triggering the production of acoustic waves, which can be collected and reconstructed to provide high-resolution images of features as deep as several centimeters below the body surface. Advances in hardware and software continue to bring MSOT closer to clinical translation...
June 13, 2018: Handbook of Experimental Pharmacology
https://www.readbyqxmd.com/read/29896241/dendrobium-mixture-regulates-hepatic-gluconeogenesis-in-diabetic-rats-via-the-phosphoinositide-3-kinase-protein-kinase-b-signaling-pathway
#11
Xinjun Lin, Hong Shi, Yi Cui, Xiaoning Wang, Jieping Zhang, Wenzhen Yu, Min Wei
The present study aimed to evaluate the impact of dendrobium mixture (DMix) on the gene and protein expression of insulin signaling pathway-associated factors in the livers of diabetic rats. The molecular mechanisms by which DMix inhibits gluconeogenesis were also investigated. A total of 47 female Wistar rats were used in the present study. Of these, 11 rats were randomly selected as healthy controls and diabetes was induced in the remaining 36 rats by administering a high-fat and high-sugar diet for 6 weeks, followed by two intraperitoneal injections of streptozotocin...
July 2018: Experimental and Therapeutic Medicine
https://www.readbyqxmd.com/read/29895265/reintroducing-testosterone-in-the-db-db-mouse-partially-restores-normal-glucose-metabolism-and-insulin-resistance-in-a-leptin-independent-manner
#12
Koichi Yabiku, Keiko Nakamoto, Akihiro Tokushige
BACKGROUND: Testosterone signals through the androgen receptor (AR) and AR knockout mice develop obesity, suggesting a functional association between AR and leptin signaling. Furthermore, physiological blood concentrations of testosterone have been found to inhibit the development of arteriosclerosis, obesity and diabetes. However, these findings have not been verified by testosterone replacement in animal models and whether or not testosterone acts directly by activating AR to enhance leptin signaling, or indirectly by its conversion into estrogen remains unclear...
June 13, 2018: BMC Endocrine Disorders
https://www.readbyqxmd.com/read/29894894/excess-deposition-of-collagen-in-mammary-glands-of-tamoxifen-treated-holstein-heifers-is-associated-with-impaired-mammary-growth
#13
H L M Tucker, J Holdridge, C L M Parsons, R M Akers
It is established that the ovary and estrogen are essential to bovine mammary development with the onset of puberty. Recent studies have shown that ovariectomy in the very early prepubertal period, well before onset of puberty, also dramatically impairs mammary growth. Similarly, prepubertal heifers treated with the antiestrogen tamoxifen (TAM) also exhibit markedly impaired mammary growth in correspondence with reduced estrogen receptor α (ESR1) expression. Our objective was to evaluate the effect of TAM on the mammary stroma and specifically to determine if the reported decrease in mammary development was related to changes in TAM-induced alterations in the stroma surrounding the mammary parenchyma...
May 18, 2018: Domestic Animal Endocrinology
https://www.readbyqxmd.com/read/29894467/one-year-relapse-of-mandibular-distraction-for-hemifacial-microsomia-using-masseteric-botulinum-toxin-type-a-injections
#14
Hong-Yu Yin, Chuan Wang, Zhi-Yong Zhang, Lei Shi, Lin Yin, Wei Liu, Shi Feng, Yi-Lin Cao, Xiao-Jun Tang
BACKGROUND: The relapse of hemifacial microsomia was thought to be highly related to the soft tissue envelope around the mandible angle mainly composed by masseter and medial pterygoid. According to the reason, we tried to apply masseter injection of type A botulinum toxin to weaken the soft envelope tension on the early stage post mandible distraction in adult HFM patients. METHODS: Eight patients diagnosed with HFM were studied and randomly assigned to an experimental or control group...
June 11, 2018: Journal of Craniofacial Surgery
https://www.readbyqxmd.com/read/29894458/three-dimensional-stereophotogrammetric-evaluation-of-the-efficacy-of-autologous-fat-grafting-in-the-treatment-of-parry-romberg-syndrome
#15
Valentina Pucciarelli, Camilla Baserga, Marina Codari, Giada A Beltramini, Chiarella Sforza, Aldo Bruno Giannì
Autologous fat grafting is a surgical procedure used to correct volumetric defects, atrophies, and sclerosis. Three-dimensional (3D) facial photography may enable researchers to quantify the success of surgical procedures through volumetric and surface assessments. Using 3D photography, the authors assessed the results of autologous fat grafting performed in a 15-year-old patient affected by Parry-Romberg syndrome, a rare condition resulting in progressive hemifacial atrophy of skin, subcutaneous tissues and, ultimately, bone...
June 11, 2018: Journal of Craniofacial Surgery
https://www.readbyqxmd.com/read/29892820/protocols-for-studying-how-thyroid-hormone-receptors-trigger-adaptive-thermogenesis-in-mice
#16
Karine Gauthier
The ability of thyroid hormone T3 to stimulate energy expenditure and regulate different aspects of whole body metabolism has been recognized for over a 100 years. Indeed in 1895 Adolf Magnus Levy was already describing the influence of the thyroid on setting the basal metabolic rate. Now it has been well characterized that the level of circulating T3 is correlated with energy expenditure both in humans and in rodent models (Mullur et al., Physiol Rev 94:355-382, 2014; Silva, Thyroid 5:481-492, 1995). Hypothyroidism and hyperthyroidism are respectively associated with low and high energy expenditure leading to high and low body mass index...
2018: Methods in Molecular Biology
https://www.readbyqxmd.com/read/29891446/-exendin-4-alleviates-diabetic-cardiomyopathy-in-mice-by-regulating-sirt1-pgc1%C3%AE
#17
Ying-Ying Cai, Shao-Zhou Zou, Cun-Xia Fan, Chun-Yan Wu, Shu Fang, Ping Li, Yao-Ming Xue, Mei-Ping Guan
OBJECTIVE: To investigate the protective effect of exendin-4 against diabetic cardiomyopathy in mice and explore the underlying mechanism. METHODS: C57BL/6J mice were randomly divided into normal control group with normal diet and diabetic group with high-fat diet for 4 weeks before streptozotocin injection. The successfully established diabetic mouse models were divided into diabetic group with exendin-4 treatment and diabetic control group for daily treatment with intraperitoneal injection of 1 nmol/kg exendin-4 and saline of equivalent volume for 8 weeks, respectively...
May 20, 2018: Nan Fang Yi Ke da Xue Xue Bao, Journal of Southern Medical University
https://www.readbyqxmd.com/read/29888823/20-hydroxyecdysone-upregulated-proteases-involved-in-bombyx-larval-fat-body-destruction
#18
S-Y Guo, W-M Wu, S-Y Li, Y Liu, M-Q Ye, Y Xiao, Y-J Zhong, Y Cao, K Li, L Tian
During insect larval-pupal metamorphosis, the obsolete larval organs and tissues undergo histolysis and programmed cell death (PCD) to recycle cellular materials. It has been demonstrated that some cathepsins are essential for histolysis in larval tissues, but the process of tissue destruction is not well documented. Fat body, the homologous organ to mammalian liver and adipose tissue, goes through a distinct destruction process during larval-pupal transition. Herein, we found that the Bombyx proteases, including BmCatB, BmCatD, BmCatLL-1, BmCatLL-2, BmBcp, BmMmp, BmAdamTS-1, BmAdamTS L and Bmbcpi, most of them expressed highly in fat body during feeding and metamorphosis, and occurred peak during nonfeeding molting or prepupal stage, as well as were 20E-responsive...
June 11, 2018: Insect Molecular Biology
https://www.readbyqxmd.com/read/29888578/-effect-of-electroacupuncture-on-expression-of-scavenger-receptor-a-i-in-peritoneal-macrophages-of-atherosclerotic-rabbits
#19
Ze-Dong Cheng, Wei Zhang
OBJECTIVE: To observe the effect of electroacupuncture (EA) on the expression of scavenger receptor A I (SR-A I) protein and mRNA in peritoneal macrophages of atherosclerosis (AS) rabbits. METHODS: A total of 26 New Zealand rabbits were used in the present study, among them, 7 were randomly selected to constitute a blank control group, and the rest 19 rabbits were fed with high-fat diet combined with carotid artery balloon injury for establishing AS model. Eight weeks after high-fat forage feeding, one high-fat fed rabbit and one normal rabbit were randomly selected for verifying the success of modeling...
April 25, 2018: Zhen Ci Yan Jiu, Acupuncture Research
https://www.readbyqxmd.com/read/29885466/comparative-analysis-on-liver-transcriptome-profiles-of-different-methods-to-establish-type-2-diabetes-mellitus-models-in-guangxi-bama-mini-pig
#20
Yanjun Wu, Li Zhang, Jing Liang, Qinyang Jiang, Yafen Guo, Ganqiu Lan
AIMS/INTRODUCTION: Streptozotocin (STZ) is a permanent diabetogenic compound and often used in animal diabetes modeling. The aim of this study is to compare the liver transcriptome of type 2 diabetes models (T2DM) in Guangxi Bama Mini-pig (GBM pig) induced by STZ or Non-STZ. RESEARCH DESIGN AND METHODS: 22 female GBM pigs were divided into 4 groups. Ctr group (4 pigs): standard diets; DM1_HH group (10 pigs): high fat and high carbohydrate diets; DM2_HS group (4 pigs): high fat and high carbohydrate diets + STZ; DM3_SH group (4 pigs): STZ + high fat and high carbohydrate diets...
June 6, 2018: Gene
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