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https://www.readbyqxmd.com/read/29444083/high-fat-diet-sensitizes-fibromyalgia-like-pain-behaviors-in-mice-via-tumor-necrosis-factor-alpha
#1
Dan Tian, Miao Tian, Leilei Zhang, Peng Zhao, Yunfeng Cui, Jinlong Li
Fibromyalgia (FM) and obesity are closely related. However, little is known about how obesity contributes to FM. Importantly, adequate evidence has shown that tumor necrosis factor alpha (TNF-α) plays a critical role in obesity. Thus, we hypothesized that obesity-induced TNF-α release may potentiate FM-associated pain. To test this hypothesis, we investigated the role of TNF-α in the development of FM-like pain in a mouse model of acid saline injection-induced FM. Consistent with previous reports, we showed that repeated acid saline injections induced bilateral mechanical hyperalgesia, and this effect lasted for at least 4 days after acid saline injections...
2018: PloS One
https://www.readbyqxmd.com/read/29443828/fat-grafting-for-facial-rejuvenation-and-contouring-a-rationalized-approach
#2
Lee L Q Pu
The clinical outcome after fat grafting for facial rejuvenation and contouring can be less optimal because lack of standardized techniques is performed by the surgeon for the procedure. In this review, the author has tried to provide a rationalized approach to fat grafting for facial rejuvenation and contouring. The preferred donor sites include low abdomen and inner thigh especially in younger patients. Fat grafts should be harvested with low negative pressure via syringe liposuction technique to ensure the integrity as well as the optimal level of cellular function...
February 13, 2018: Annals of Plastic Surgery
https://www.readbyqxmd.com/read/29442728/inhibition-of-p53-relieves-insulin-resistance-in-fetal-growth-restriction-mice-with-catch-up-growth-via-activating-igfbp3-igf-1-irs-1-akt-signaling-pathway
#3
Ping Peng, Chunling Ma, Shumei Wan, Wensheng Jin, Yan Gao, Tianqing Huang, Qi Cheng, Changlan Ye
To investigate insulin resistance of the fetal growth restriction (FGR) mice with catch-up growth (CUG) and the underlying mechanism, in this study, low protein diet was used during pregnancy to establish the FGR mice model, and high fat diet was applied to establish the CUG model of FGR mice. The insulin and Pifithrin-α stimulation was performed via intraperitoneal injection. The physical characters, biochemical parameters, expression of related molecules in each group were detected via ELISA, RT-PCR, WB, etc...
June 1, 2018: Journal of Nanoscience and Nanotechnology
https://www.readbyqxmd.com/read/29437870/cpt2-downregulation-adapts-hcc-to-lipid-rich-environment-and-promotes-carcinogenesis-via-acylcarnitine-accumulation-in-obesity
#4
Naoto Fujiwara, Hayato Nakagawa, Kenichiro Enooku, Yotaro Kudo, Yuki Hayata, Takuma Nakatsuka, Yasuo Tanaka, Ryosuke Tateishi, Yohko Hikiba, Kento Misumi, Mariko Tanaka, Akimasa Hayashi, Junji Shibahara, Masashi Fukayama, Junichi Arita, Kiyoshi Hasegawa, Hadassa Hirschfield, Yujin Hoshida, Yoshihiro Hirata, Motoyuki Otsuka, Keisuke Tateishi, Kazuhiko Koike
OBJECTIVE: Metabolic reprogramming of tumour cells that allows for adaptation to their local environment is a hallmark of cancer. Interestingly, obesity-driven and non-alcoholic steatohepatitis (NASH)-driven hepatocellular carcinoma (HCC) mouse models commonly exhibit strong steatosis in tumour cells as seen in human steatohepatitic HCC (SH-HCC), which may reflect a characteristic metabolic alteration. DESIGN: Non-tumour and HCC tissues obtained from diethylnitrosamine-injected mice fed either a normal or a high-fat diet (HFD) were subjected to comprehensive metabolome analysis, and the significance of obesity-mediated metabolic alteration in hepatocarcinogenesis was evaluated...
February 6, 2018: Gut
https://www.readbyqxmd.com/read/29436841/fat-suppression-in-magnetic-resonance-imaging-of-the-head-and-neck-region-is-the-two-point-dixon-technique-superior-to-spectral-fat-suppression
#5
Christina Margareta Wendl, Johannes Eiglsperger, Lena-Marie Dendl, Harald Brodoefel, Karl-Michael Schebesch, Christian Stroszczynski, Claudia Fellner
OBJECTIVE: The aim of our study was to systematically compare two-point Dixon fat suppression (FS) and spectral FS techniques in contrast enhanced imaging of the head and neck region. METHODS: Three independent readers analysed coronal T1-weighted images recorded after contrast medium injection with Dixon and spectral FS techniques with regard to fat suppression homogeneity, motion artefacts, lesion contrast, image sharpness and overall image quality. RESULTS: 85 patients were prospectively enrolled in the study...
February 13, 2018: British Journal of Radiology
https://www.readbyqxmd.com/read/29436657/effect-of-notoginsenoside-r1-on-autologous-adipose-graft-in-rats
#6
Guizong Chen, Qin Li, Yanping Luo, Tao Liu, Shaolong Zhou, Er Pan, Lixia Peng
Autologous fat particle transplantation has been widely used by surgeons. The present study evaluated the effect of Notoginsenoside R1 (NR1) treatment on rat autologous fat graft, along with the quality and retention rates. Male Sprague‑Dawley rats (n=60) received fat particle auto‑transplantation from the left abdominal cavity into lateral dorsum. A total of 14 days after surgery, NR1 in different doses (50, 100 and 200 mg/kg/day) was injected into rats, following which blood and fat graft samples were harvested at days 7, 14 and 28...
February 13, 2018: Molecular Medicine Reports
https://www.readbyqxmd.com/read/29435181/hyperglycemia-induced-testicular-damage-in-type-2-diabetes-mellitus-rats-exhibiting-microcirculation-impairments-associated-with-vascular-endothelial-growth-factor-decreased-via-pi3k-akt-pathway
#7
Lingli Long, Han Qiu, Bing Cai, Ningning Chen, Xiaofang Lu, Shuhui Zheng, Xiaoxin Ye, Yubin Li
As an endocrine disease, type 2 diabetes mellitus (T2DM) can cause testicular damage which induces male infertility. However, the underlying mechanism is still not clear. We prove that T2DM induced testicular microcirculation impairment involves the decrease of VEGF and these actions are regulated by PI3K/Akt pathway. In our study, rats were divided into three groups (n=8): control group, diabetes group and diabetes + VEGF group. Intraperitoneal injection of streptozotocin (STZ, 65mg/Kg, at 9th week) and daily high-fat diet were used to establish T2DM rat model...
January 12, 2018: Oncotarget
https://www.readbyqxmd.com/read/29434819/tangshen-formula-improves-inflammation-in-renal-tissue-of-diabetic-nephropathy-through-sirt1-nf-%C3%AE%C2%BAb-pathway
#8
Yue-Guang Du, Ke-Na Zhang, Zong-Lei Gao, Fengjiao Dai, Xi-Xi Wu, Ke-Fu Chai
The present study investigated the mechanism underlying the anti-inflammatory effects of Tangshen formula (TS) in Sprague Dawley (SD) rats with diabetic nephropathy (DN). A rat model of DN was established by intraperitoneal injection of 1% (40 mg/kg) streptozotocin and administration of a high fat and glucose diet. Subsequently, SD rats were randomly divided into six groups (n=8): A DN group, a valsartan group, a high-dose TS group, a middle-dose TS group, a low-dose TS group and a control group with normal SD rats...
February 2018: Experimental and Therapeutic Medicine
https://www.readbyqxmd.com/read/29434785/nephroprotective-effects-of-diacylglycerol-on-diabetic-nephropathy-in-type-2-diabetic-rats
#9
Jianpeng Li, Yongheng Yan, Duo Li, Xia Li, Xinying Lin, Zhenhua Liu, Tongcheng Xu, Fangling Du
Diacylglycerol (DAG) has been reported to reduce the serum lipid and glucose levels more effectively compared with triacylglycerol (TAG). The present study examined the long-term effects of dietary DAG on rats with type 2 diabetic nephropathy (DN). The type 2 DN model was established by administering a high-fat and high-calorie diet along with an intraperitoneal injection of 35 mg/kg body weight streptozocin, and the disease developed over the following 8 weeks. Sprague-Dawley rats were then randomly divided into the control, TAG, low-dose DAG (Low-DAG) and high-dose DAG (High-DAG) groups...
February 2018: Experimental and Therapeutic Medicine
https://www.readbyqxmd.com/read/29429513/protective-roles-of-rutin-against-restraint-stress-on-spermatogenesis-in-testes-of-adult-mice
#10
Asif Mehfooz, Quanwei Wei, Kaizhi Zheng, Mohamed Babo Fadlalla, Gracijela Maltasic, Fangxiong Shi
In order to investigate the effects of Rutin against restraint stress, 50 adult male mice were divided into five groups: control, restraint stress (RS), and RS with 2 doses of Rutin treatments. Mice were restrained in a conical tube for 4 h daily and Rutin was injected intraperitoneally for 15 consecutive days. Restraint stress significantly decreases body weights, testis and epididymis weights, thymus weights, visceral fats, serum concentrations of testosterone, sperm counts, sperm motility and sperm viability, while it increases serum epinephrine levels, adrenal gland weights and abnormal sperms...
February 2018: Tissue & Cell
https://www.readbyqxmd.com/read/29429367/obestatin-protects-and-reverses-nonalcoholic-fatty-liver-disease-and-its-associated-insulin-resistance-in-rats-via-inhibition-of-food-intake-enhancing-hepatic-adiponectin-signaling-and-blocking-ghrelin-acylation
#11
Eman F Khaleel, Ghada A Abdel-Aleem
This study investigated the ameliorative and protective effects of long-term obestatin administration (80 nmol/kg/ intraperitoneal injection (i.p.)) on the pathogenesis of high-fat diet (HFD) induced nonalcoholic fatty liver disease (NAFLD) in rats. Rats (n = 8/group) were divided as control, NAFLD, NAFLD + Simvastatin, NAFLD + obestatin, NAFLD then obestatin, and obestatin then NAFLD. Obestatin co -or post-therapy significantly reduced hepatomegaly and reversed hyperlipidemia, hepatic lipid accumulation, and insulin resistance (IR)...
February 10, 2018: Archives of Physiology and Biochemistry
https://www.readbyqxmd.com/read/29428734/co-transplantation-of-exosomes-derived-from-hypoxia-preconditioned-adipose-mesenchymal-stem-cells-promotes-neovascularization-and-graft-survival-in-fat-grafting
#12
Yu-di Han, Yun Bai, Xin-Long Yan, Jing Ren, Quan Zeng, Xiao-Dong Li, Xue-Tao Pei, Yan Han
BACKGROUND: Adipose-derived stromal cells (ADSCs)-derived exosomes (ADSC-Exos) account for the proangiogenic potential of stem cell. This study aimed to investigate the effect of ADSC-derived exosomes (ADSC-Exos) on the survival in fat grafting. METHODS: A nude mouse model of subcutaneous fat grafting was adopted. Hypoxic preconditioned ADSC-Exos and ADSC-Exos were injected around the grafted tissue. The fat graft sample was weighed and examined by hematoxylin and eosin (H&E) staining and immunohistochemistry...
February 8, 2018: Biochemical and Biophysical Research Communications
https://www.readbyqxmd.com/read/29427700/new-arguments-for-beneficial-effects-of-alpha-lipoic-acid-on-the-cardiovascular-system-in-the-course-of-type-2-diabetes
#13
Marzena Dworacka, Galina Chukanova, Saule Iskakova, Yergen Kurmambayev, Anna Wesołowska, Bartosz A Frycz, Paweł P Jagodziński, Grzegorz Dworacki
PURPOSE: Alpha-lipoic acid (ALA), widely known as an antioxidant, modifies also serum levels of angiogenic factors in type 2 diabetic patients. These pharmacological activities may influence the status of the cardiovascular system. Taking into consideration that diabetes is related to the increased cardiovascular risk we investigated several effects of ALA on angiogenic factors in the myocardium and in the aortal wall using a rat model of type 2 diabetes. METHODS: Diabetes was induced in Wistar rats by a fat-rich diet and by intraperitoneal injection of a small dose of streptozotocin (30 mg/kg)...
February 7, 2018: European Journal of Pharmaceutical Sciences
https://www.readbyqxmd.com/read/29421579/polyphenol-enriched-extract-of-rosa-rugosa-thunb-regulates-lipid-metabolism-in-diabetic-rats-by-activation-of-ampk-pathway
#14
Liu Liu, Mireguli Yasen, Dan Tang, Jianping Ye, Haji Akber Aisa, Xuelei Xin
This study was designed to investigate the mechanism of polyphenol-enriched extract of Rosa rugosa Thunb (RPE) in the control of dyslipidemia in diabetic rats. RPE was tested at three dosages (37.5 mg/kg, 75 mg/kg and 150 mg/kg) in the rat dyslipidemia model established with high fat diet feeding in combination with STZ injection (30 mg/kg). The RPE effect was evaluated after 4 weeks of treatment. In the RPE-treated rats, hepatic total cholesterol (TC) and triglyceride (TG) were significantly reduced, lipoprotein lipase (LPL) and liver lipase (HL) were significantly increased...
February 5, 2018: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/29421441/simultaneous-determination-of-vitamin-a-25-hydroxyl-vitamin-d3-%C3%AE-tocopherol-in-small-biological-fluids-by-liquid-chromatography-tandem-mass-spectrometry
#15
Haifeng Zhang, Li Quan, Pei Pei, Ye Lin, Chao Feng, Hongyan Guan, Fang Wang, Ting Zhang, Jianxin Wu, Junsheng Huo
A sensitive method for the simultaneous analysis of vitamin A (VA), 25-hydroxyl vitamin D3 (25-OH VD3) and α-tocopherol (VE) in children plasma by liquid chromatography-tandem mass spectrometry (LC-MS/MS) has been developed and validated. Sample preparation chose the solid phase extraction. 100 μL of plasma was mixed with 300 μL ethanol contained 4 μL isotope-labelled analytes. After a series operation, the supernatant was applied to the solid phase extraction (SPE) plate (HLB μElution plate). The eluate was evaporated, and reconstituted in 100 μL methanol...
December 15, 2017: Journal of Chromatography. B, Analytical Technologies in the Biomedical and Life Sciences
https://www.readbyqxmd.com/read/29417261/the-ratio-of-adscs-to-hsc-progenitors-in-adipose-tissue-derived-svf-may-provide-the-key-to-predict-the-outcome-of-stem-cell-therapy
#16
Mehmet Okyay Kilinc, Antonio Santidrian, Ivelina Minev, Robert Toth, Dobrin Draganov, Duong Nguyen, Elliot Lander, Mark Berman, Boris Minev, Aladar A Szalay
BACKGROUND: Stromal vascular fraction (SVF) represents an attractive source of adult stem cells and progenitors, holding great promise for numerous cell therapy approaches. In 2017, it was reported that 1524 patients received autologous SVF following the enzymatic digestion of liposuction fat. The treatment was safe and effective and patients showed significant clinical improvement. In a collaborative study, we analyzed SVF obtained from 58 patients having degenerative, inflammatory, autoimmune diseases, and advanced stage cancer...
February 7, 2018: Clinical and Translational Medicine
https://www.readbyqxmd.com/read/29414510/adiponectin-as-lncrna-inhibits-adipogenesis-by-transferring-from-nucleus-to-cytoplasm-and-attenuating-adiponectin-mrna-translation
#17
Rui Cai, Yunmei Sun, Naren Qimuge, Guoqiang Wang, Yingqian Wang, Guiyan Chu, Taiyong Yu, Gongshe Yang, Weijun Pang
Adiponectin (AdipoQ) is an adipocyte-derived hormone with positive function on systemic glucose and lipid metabolism. Long noncoding RNA (lncRNA) is emerging as a vital regulator of adipogenesis. However, AdipoQ-related lncRNAs in lipid metabolism have not been explored. Here, AdipoQ antisense (AS) lncRNA was first identified, and we further found that it inhibited adipogenesis. The half-life of AdipoQ AS lncRNA was 10 h, whereas that of AdipoQ mRNA was 4 h. During adipogenic differentiation, AdipoQ AS lncRNA translocated from nucleus to cytoplasm...
January 29, 2018: Biochimica et Biophysica Acta
https://www.readbyqxmd.com/read/29409496/gold-nanoparticles-improve-metabolic-profile-of-mice-fed-a-high-fat-diet
#18
Hui Chen, Jane P M Ng, Yi Tan, Kristine McGrath, David P Bishop, Brian Oliver, Yik Lung Chan, Michael B Cortie, Bruce K Milthorpe, Stella M Valenzuela
BACKGROUND: Obesity is a high risk for multiple metabolic disorders due to excessive influx of energy, glucose and lipid, often from a western based diet. Low-grade inflammation plays a key role in the progression of such metabolic disorders. The anti-inflammatory property of gold compounds has been used in treating rheumatoid arthritis in the clinic. Previously we found that pure gold nanoparticles (AuNPs, 21 nm) also possess anti-inflammatory effects on the retroperitoneal fat tissue following intraperitoneal injection, by downregulating tumor necrosis factor (TNF) α...
February 6, 2018: Journal of Nanobiotechnology
https://www.readbyqxmd.com/read/29409356/therapeutic-potential-of-lentivirus-mediated-glucagon-like-peptide-1-glp-1-gene-therapy-for-diabetes
#19
Hale M Tasyurek, Hasan A Altunbas, Mustafa K Balci, Thomas S Griffith, Salih Sanlioglu
Postprandial glucose-induced insulin secretion from the islets of Langerhans is facilitated by glucagon-like peptide-1 (GLP-1) - a metabolic hormone with insulinotropic properties. Among the variety of effects it mediates, GLP-1 induces delta cell secretion of somatostatin, inhibits alpha cell release of glucagon, reduces gastric emptying, and slows food intake. These events collectively contribute to weight loss over time. During type 2 diabetes (T2DM), however, the incretin response to glucose is reduced and accompanied by a moderate reduction in GLP-1 secretion...
February 6, 2018: Human Gene Therapy
https://www.readbyqxmd.com/read/29404511/exenatide-induces-carcinoembryonic-antigen-related-cell-adhesion-molecule-1-expression-to-prevent-hepatic-steatosis
#20
Hilda E Ghadieh, Harrison T Muturi, Lucia Russo, Christopher C Marino, Simona S Ghanem, Saja S Khuder, Julie C Hanna, Sukanta Jash, Vishwajeet Puri, Garrett Heinrich, Cara Gatto-Weis, Kevin Y Lee, Sonia M Najjar
Exenatide, a glucagon-like peptide-1 receptor agonist, induces insulin secretion. Its role in insulin clearance has not been adequately examined. Carcinoembryonic antigen-related cell adhesion molecule 1 (CEACAM1) promotes hepatic insulin clearance to maintain insulin sensitivity. Feeding C57BL/6J mice a high-fat diet down-regulates hepatic Ceacam1 transcription to cause hyperinsulinemia, insulin resistance, and hepatic steatosis, as in Ceacam1 null mice (Cc1-/- ). Thus, we tested whether exenatide regulates Ceacam1 expression in high-fat diet-fed mice and whether this contributes to its insulin sensitizing effect...
January 2018: Hepatology Communications
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