Tobias Piotrowski, Oliver Rippel, Andreas Elanzew, Bastian Nießing, Sebastian Stucken, Sven Jung, Niels König, Simone Haupt, Laura Stappert, Oliver Brüstle, Robert Schmitt, Stephan Jonas
Human induced pluripotent stem cells (hiPSCs) are capable of differentiating into a variety of human tissue cells. They offer new opportunities for personalized medicine and drug screening. This requires large quantities of high quality hiPSCs, obtainable only via automated cultivation. One of the major requirements of an automated cultivation is a regular, non-invasive analysis of the cell condition, e.g. by whole-well microscopy. However, despite the urgency of this requirement, there are currently no automatic, image-processing-based solutions for multi-class routine quantification of this nature...
December 11, 2020: Computers in Biology and Medicine