Valeria Calabrese, Barbara Picconi, Nicolas Heck, Federica Campanelli, Giuseppina Natale, Gioia Marino, Miriam Sciaccaluga, Veronica Ghiglieri, Alessandro Tozzi, Estelle Anceaume, Emeline Cuoc, Jocelyne Caboche, François Conquet, Paolo Calabresi, Delphine Charvin
By decreasing glutamate transmission, mGlu4 receptor positive allosteric modulators (mGlu4-PAM), in combination with levodopa (l-DOPA) may restore the synergy between glutamatergic and dopaminergic transmissions, thus maximizing the improvement of motor function in Parkinson's disease (PD). This study aimed to clarify the effects of foliglurax, a selective mGlu4-PAM, on the loss of bidirectional synaptic plasticity associated with l-DOPA-induced dyskinesia (LID). Behavioral assessments compared dyskinesia intensity in 6-hydroxydopamine (6-OHDA)-lesioned rats treated with l-DOPA or l-DOPA plus foliglurax...
August 5, 2022: Neuropharmacology