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Parvovirus b19

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https://www.readbyqxmd.com/read/28412176/human-parvovirus-b19-nosocomial-outbreak-in-healthcare-personnel-in-a-paediatric-ward-at-a-national-tertiary-referral-centre-in-thailand
#1
S Sungkate, W Phongsamart, S Rungmaitree, K Lapphra, O Wittawatmongkol, V Pumsuwan, N Wiruchkul, S Assanasen, Y Rongrungruang, N Onlamoon, N Horthongkham, W Lermankul, N Kongstan, K Chokephaibulkit
BACKGROUND: Nosocomial outbreaks of parvovirus B19 (pB19) have been reported, but they rarely occur among healthcare personnel (HCP). Susceptibility among pregnant HCP was the major concern. METHODS: An outbreak of pB19 among HCP is described in a paediatric ward with a cross-sectional serologic study in all HCP and patients exposed to the outbreak. Acute infection was diagnosed by polymerase chain reaction or positive anti-parvovirus B19 IgM. FINDINGS: Among 48 HCP (three pregnant) and 22 patients included in the outbreak serologic study, 11 (23%) HCP and two (9%) patients had acute infection...
March 18, 2017: Journal of Hospital Infection
https://www.readbyqxmd.com/read/28410597/the-role-of-nuclear-localization-signal-in-parvovirus-life-cycle
#2
REVIEW
Peng Liu, Shun Chen, Mingshu Wang, Anchun Cheng
Parvoviruses are small, non-enveloped viruses with an approximately 5.0 kb, single-stranded DNA genome. Usually, the parvovirus capsid gene contains one or more nuclear localization signals (NLSs), which are required for guiding the virus particle into the nucleus through the nuclear pore. However, several classical NLSs (cNLSs) and non-classical NLSs (ncNLSs) have been identified in non-structural genes, and the ncNLSs can also target non-structural proteins into the nucleus. In this review, we have summarized recent research findings on parvovirus NLSs...
April 14, 2017: Virology Journal
https://www.readbyqxmd.com/read/28403966/-intrauterine-blood-transfusion-status-report-of-4years-of-practice-in-france-2011-2014
#3
A Girault, S Friszer, E Maisonneuve, L Guilbaud, A Cortey, J-M Jouannic
OBJECTIVES: The aim of our study was to evaluate in utero blood transfusion's (IUT) performed in France, among the French prenatal diagnosis centers in order to study the etiology of severe anemia requiring IUT. METHODS: We conducted a national retrospective descriptive study between 2011 and 2014. The data were collected using a survey sent by email to all French prenatal diagnosis centers. RESULTS: Among the 49 centers, 18 (38 %) had performed at least one IUT during the study period...
February 2017: J Gynecol Obstet Hum Reprod
https://www.readbyqxmd.com/read/28401102/human-parvovirus-b19-in-patients-with-beta-thalassemia-major-from-tehran-iran
#4
Seyed Ali Mohammad Arabzadeh, Farideh Alizadeh, Ahmad Tavakoli, Hamidreza Mollaei, Farah Bokharaei-Salim, Gharib Karimi, Mohammad Farahmand, Helya Sadat Mortazavi, Seyed Hamidreza Monavari
BACKGROUND: Due to the tropism of human parvovirus B19 to erythroid progenitor cells, infection in patients with an underlying hemolytic disorder such as beta-thalassemia major leads to suppression of erythrocyte formation, referred to as transient aplasia crisis (TAC), which may be life-threatening. We investigated the prevalence of parvovirus B19 among patients with beta thalassemia major attending the Zafar Adult Thalassemia Clinic in Tehran, Iran. METHODS: This cross-sectional study was performed to determine the presence of parvovirus B19 DNA in blood samples and parvovirus B19 genotypes in plasma samples of patients with thalassemia major...
March 2017: Blood Research
https://www.readbyqxmd.com/read/28398685/parvovirus-b19-infection-during-pregnancy-and-risks-to-the-fetus
#5
REVIEW
Asher Ornoy, Zivanit Ergaz
Parvovirus B19 infects 1 to 5% of pregnant women, generally with normal pregnancy outcomes. During epidemics, the rate of infection is higher. Major congenital anomalies among offspring of infected mothers are rare, as the virus does not appear to be a significant teratogen. However, parvovirus B19 infection may cause significant fetal damage, and in rare cases, brain anomalies and neurodevelopmental insults, especially if infection occurs in the first 20 weeks of pregnancy. Parvovirus B19 is also an important cause of fetal loss, especially in the second half of pregnancy when spontaneous fetal loss from other causes is relatively rare...
March 15, 2017: Birth Defects Res
https://www.readbyqxmd.com/read/28397477/real-time-pcr-detection-of-the-most-common-bacteria-and-viruses-causing-meningitis
#6
Oya Akkaya, Hulya Iren Guvenc, Serife Yuksekkaya, Aysegul Opus, Asuman Guzelant, Meral Kaya, Muhammet Guzel Kurtoglu, Nurettin Kaya
BACKGROUND: Central nervous system (CNS) infections require prompt diagnosis, as the clinical condition progresses rapidly and may lead to severe permanent sequelae or death. The causative agents include viruses, bacteria, fungi, and parasites. In this study, samples with the diagnosis of CNS infection based on cerebrospinal fluid (CSF) sent to us from other hospitals/labs, were studied by multiplex real-time Polymerase Chain Reaction (PCR) method. The purpose of this study is to demonstrate, retrospectively, the most common bacteria and viruses causing meningitis and seasonal distribution of these agents using the multiplex real-time PCR method in CSF samples...
April 1, 2017: Clinical Laboratory
https://www.readbyqxmd.com/read/28387173/pure-red-cell-aplasia-due-to-parvovirus-b19-erythropoietin-resistant-anemia-in-a-pediatric-kidney-recipient
#7
Baris Malbora, Serdar Saritas, Eda Ataseven, Burcu Belen, Caner Alparslan, Onder Yavascan, Dilek Yilmaz Ciftdogan, Berna Atabay, Meral Turker
No abstract text is available yet for this article.
April 6, 2017: Experimental and Clinical Transplantation
https://www.readbyqxmd.com/read/28377277/hydroxyurea-inhibits-parvovirus-b19-replication-in-erythroid-progenitor-cells
#8
Francesca Bonvicini, Gloria Bua, Ilaria Conti, Elisabetta Manaresi, Giorgio Gallinella
Parvovirus B19 (B19V) infection is restricted to erythroid progenitor cells (EPCs) of the human bone marrow, leading to transient arrest of erythropoiesis and severe complications mainly in subjects with underlying hematological disorders or with immune system deficits. Currently, there are no specific antiviral drugs for B19V treatment, but identification of compounds inhibiting B19V replication can be pursued by a drug repositioning strategy. In this frame, the present study investigates the activity of hydroxyurea (HU), the only disease-modifying therapy approved for sickle cell disease (SCD), towards B19V replication in the two relevant cellular systems, the UT7/EpoS1 cell line and EPCs...
April 1, 2017: Biochemical Pharmacology
https://www.readbyqxmd.com/read/28374737/extinct-type-of-human-parvovirus-b19-persists-in-tonsillar-b-cells
#9
Lari Pyöriä, Mari Toppinen, Elina Mäntylä, Lea Hedman, Leena-Maija Aaltonen, Maija Vihinen-Ranta, Taru Ilmarinen, Maria Söderlund-Venermo, Klaus Hedman, Maria F Perdomo
Parvovirus B19 (B19V) DNA persists lifelong in human tissues, but the cell type harbouring it remains unclear. We here explore B19V DNA distribution in B, T and monocyte cell lineages of recently excised tonsillar tissues from 77 individuals with an age range of 2-69 years. We show that B19V DNA is most frequent and abundant among B cells, and within them we find a B19V genotype that vanished from circulation >40 years ago. Since re-infection or re-activation are unlikely with this virus type, this finding supports the maintenance of pathogen-specific humoral immune responses as a consequence of B-cell long-term survival rather than continuous replenishment of the memory pool...
April 4, 2017: Nature Communications
https://www.readbyqxmd.com/read/28373861/environmental-issues-in-thyroid-diseases
#10
REVIEW
Silvia Martina Ferrari, Poupak Fallahi, Alessandro Antonelli, Salvatore Benvenga
Environmental factors are determinant for the appearance of autoimmune thyroid diseases (AITD) in susceptible subjects. Increased iodine intake, selenium, and vitamin D deficiency, exposure to radiation, from nuclear fallout or due to medical radiation, are environmental factors increasing AITD. Cigarette smoking is associated with Graves' disease and Graves' ophthalmopathy, while it decreases the risk of hypothyroidism and thyroid autoimmunity. Viral infections are important environmental factors in the pathogenesis of AITD, too, particularly human parvovirus B19 (EVB19) and hepatitis C virus...
2017: Frontiers in Endocrinology
https://www.readbyqxmd.com/read/28369973/persistent-symptomatic-parvovirus-b19-infection-with-severe-thrombocytopenia-transmitted-by-red-blood-cell-transfusion-containing-low-parvovirus-b19-dna-levels
#11
Keiki Nagaharu, Yuka Sugimoto, Yuji Hoshi, Takanori Yamaguchi, Ryugo Ito, Keiji Matsubayashi, Keiki Kawakami, Kohshi Ohishi
BACKGROUND: Transfusion-mediated human parvovirus B19 (PVB19) infection is rare but often causes severe hematologic disorders. In Japan, routine blood donor screening for PVB19 antigen (detection sensitivity, 10(6.4) IU/mL) using a chemiluminescent enzyme immunoassay (CLEIA) was introduced in 2008. However, there is no consensus on the minimal infectious dose of PVB19 permissible for red blood cells (RBCs). CASE REPORT: A 64-year-old man, who had received hemodialysis for diabetic nephropathy for 5 years, underwent an RBC transfusion for anemia caused by hemorrhagic enterocolitis...
April 2, 2017: Transfusion
https://www.readbyqxmd.com/read/28366188/corrigendum-the-plasma-virome-of-febrile-adult-kenyans-shows-frequent-parvovirus-b19-infections-and-a-novel-arbovirus-kadipiro-virus
#12
Carolyne N Ngoi, Juliana Siqueira, Linlin Li, Xutao Deng, Peter Mugo, Susan M Graham, Matt A Price, Eduard J Sanders, Eric Delwart
No abstract text is available yet for this article.
March 2017: Journal of General Virology
https://www.readbyqxmd.com/read/28358698/increased-numbers-of-cd4-cd25-and-cd8-cd25-t-cells-in-peripheral-blood-of-patients-with-rheumatoid-arthritis-with-parvovirus-b19-infection
#13
Milda Naciute, Gabriele Maciunaite, Diana Mieliauskaite, Rita Rugiene, Aukse Zinkeviciene, Mykolas Mauricas, Modra Murovska, Irute Girkontaite
AIM: To investigate T-cell subpopulations in peripheral blood of human parvovirus B19 DNA-positive (B19(+)) and -negative (B19(-)) patients with rheumatoid arthritis (RA) and healthy persons. PATIENTS AND METHODS: Blood samples were collected from 115 patients with RA and 47 healthy volunteers; 27 patients with RA and nine controls were B19(+) Cluster of differentiation (CD) 4, 8, 25 and 45RA were analyzed on blood cells. CD25 expression on CD4(+)CD45RA(+), CD4(+)CD45RA(-), CD8(+)CD45RA(+), CD8(+)CD45RA(-) subsets were analyzed by flow cytometry...
March 2017: In Vivo
https://www.readbyqxmd.com/read/28352491/acquired-factor-viii-deficiency-two-case-reports-and-a-review-of-literature
#14
Lan Mo, George C Bao
BACKGROUND: Acquired factor VIII (FVIII) deficiency, or acquired hemophilia A (AHA), is a rare autoimmune disorder involving antibody-mediated depletion of coagulation FVIII, leading to severe, life-threatening bleeding. The condition is often associated with other autoimmune disorders, and its treatment involves replacement of FVIII and various modes of immunosuppression. Recently, a few noteworthy therapeutic advances have been made. We present two cases of severe AHA in Chinese women...
2017: Experimental Hematology & Oncology
https://www.readbyqxmd.com/read/28328962/the-blood-dna-virome-in-8-000-humans
#15
Ahmed Moustafa, Chao Xie, Ewen Kirkness, William Biggs, Emily Wong, Yaron Turpaz, Kenneth Bloom, Eric Delwart, Karen E Nelson, J Craig Venter, Amalio Telenti
The characterization of the blood virome is important for the safety of blood-derived transfusion products, and for the identification of emerging pathogens. We explored non-human sequence data from whole-genome sequencing of blood from 8,240 individuals, none of whom were ascertained for any infectious disease. Viral sequences were extracted from the pool of sequence reads that did not map to the human reference genome. Analyses sifted through close to 1 Petabyte of sequence data and performed 0.5 trillion similarity searches...
March 2017: PLoS Pathogens
https://www.readbyqxmd.com/read/28288327/parvovirus-b19-infection-modulates-the-levels-of-cytokines-in-the-plasma-of-rheumatoid-arthritis-patients
#16
Milda Naciute, Diana Mieliauskaite, Rita Rugiene, Gabriele Maciunaite, Mykolas Mauricas, Modra Murovska, Irute Girkontaite
BACKGROUND: Parvovirus B19 (B19V) infection is associated with various autoimmune diseases. We investigated the levels of pro-inflammatory (IFNᵧ, TNFα, IL-2, IL-12) and anti-inflammatory (IL-4, IL-10) cytokines in the plasma of B19V DNA positive (B19(+)) and negative (B19(-)) rheumatoid arthritis (RA) patients in comparison with the control group (healthy persons). METHODS: Blood samples were collected from 118 patients with RA and 49 healthy voluntaries. B19V sequence was determined in whole blood and cell-free plasma DNA by nested PCR...
March 10, 2017: Cytokine
https://www.readbyqxmd.com/read/28264028/parvovirus-b19-ns1-protein-induces-cell-cycle-arrest-at-g2-phase-by-activating-the-atr-cdc25c-cdk1-pathway
#17
Peng Xu, Zhe Zhou, Min Xiong, Wei Zou, Xuefeng Deng, Safder S Ganaie, Steve Kleiboeker, Jianxin Peng, Kaiyu Liu, Shengqi Wang, Shui Qing Ye, Jianming Qiu
Human parvovirus B19 (B19V) infection of primary human erythroid progenitor cells (EPCs) arrests infected cells at both late S-phase and G2-phase, which contain 4N DNA. B19V infection induces a DNA damage response (DDR) that facilitates viral DNA replication but is dispensable for cell cycle arrest at G2-phase; however, a putative C-terminal transactivation domain (TAD2) within NS1 is responsible for G2-phase arrest. To fully understand the mechanism underlying B19V NS1-induced G2-phase arrest, we established two doxycycline-inducible B19V-permissive UT7/Epo-S1 cell lines that express NS1 or NS1mTAD2, and examined the function of the TAD2 domain during G2-phase arrest...
March 2017: PLoS Pathogens
https://www.readbyqxmd.com/read/28263841/the-formation-and-modification-of-chromatin-like-structure-of-human-parvovirus-b19-regulate-viral-genome-replication-and-rna-processing
#18
Huanzhou Xu, Sujuan Hao, Junmei Zhang, Zhen Chen, Hanzhong Wang, Wuxiang Guan
B19 virus (B19V) is a single stranded virus in the genus of Erythroparvovirus in the family of Parvoviridae. One of the limiting steps of B19V infection is the replication of viral genome which affected the alternative processing of its RNA. Minute virus of mice (MVM) and adeno-associated virus (AAV) has been reported to form chromatin-like structure within hours after infection of cells. However, the role of chromatin-like structure is unclear. In the present study, we found that B19V formed chromatin-like structure after 12h when B19V infectious clone was co-transfected with pHelper plasmid to HEK293T cells...
March 2, 2017: Virus Research
https://www.readbyqxmd.com/read/28241813/anaemia-in-hospitalised-preschool-children-from-a-rural-area-in-mozambique-a-case-control-study-in-search-for-aetiological-agents
#19
Cinta Moraleda, Ruth Aguilar, Llorenç Quintó, Tacilta Nhampossa, Montserrat Renom, Augusto Nhabomba, Sozinho Acácio, John J Aponte, Delino Nhalungo, Ariel H Achtman, Louis Schofield, Helder Martins, Eusebio Macete, Pedro L Alonso, Clara Menéndez
BACKGROUND: Young children bear the world's highest prevalence of anaemia, the majority of which is of multifactorial aetiology, which in turn hampers its successful prevention. Even moderate degrees of anaemia are associated with increased mortality and morbidity. Despite this evidence, there is a lack of effective preventive programs and absence of consensus in the safety of iron supplementation in malaria areas, which reflects the poor understanding of the contribution of different aetiologies to anaemia...
February 28, 2017: BMC Pediatrics
https://www.readbyqxmd.com/read/28196283/detection-of-human-parvovirus-b19-dna-in-22-of-1-815-cutaneous-biopsies-of-a-wide-variety-of-dermatologic-conditions-suggests-viral-persistence-after-primary-infection-and-casts-doubts-on-its-pathogenic-significance
#20
C Santonja, A Santos-Briz, G Palmedo, H Kutzner, L Requena
BACKGROUND: Human parvovirus B19 (B19V) has been associated with a number of dermatologic and systemic conditions, including myocarditis and autoimmune syndromes. OBJECTIVES: To determine the frequency of B19V deoxyribonucleic acid (DNA) detection in a large dermatopathology practice, and to characterize the histopathologic patterns involved. METHODS: We selected for polymerase chain reaction (PCR) detection of B19V a total of 1,815 skin biopsies pertaining to entities allegedly related to Parvovirus B19, as well as cases suspected clinically of representing paraviral exanthemas...
February 14, 2017: British Journal of Dermatology
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