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Parvovirus b19

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https://www.readbyqxmd.com/read/28543448/successful-treatment-of-pure-red-cell-aplasia-because-of-abo-major-mismatched-stem-cell-transplant
#1
Katie Sackett, Claudia S Cohn, Kayla Fahey-Ahrndt, Angela R Smith, Andrew D Johnson
BACKGROUND: Pure red cell aplasia (PRCA) is a well-documented potential side effect of ABO major mismatched allogeneic hematopoietic stem cell transplants. This side effect may be self-limiting, but is sometimes treated using modalities such as steroids, antithymocyte globulin, donor lymphocyte infusions, rituximab, or plasma exchanges. Another well-documented cause of pure red cell aplasia is a chronic parvovirus B19 infection, which may be seen in immunocompromised hosts. The treatment of this cause of PRCA includes removal of immunosuppression, intravenous immunoglobulin (IVIg), or rituximab; however, this condition may also be self-limiting...
May 24, 2017: Journal of Clinical Apheresis
https://www.readbyqxmd.com/read/28531186/parvovirus-b19-induced-vascular-damage-in-the-heart-is-associated-with-elevated-circulating-endothelial-microparticles
#2
Katrin Bachelier, Susanne Biehl, Viktoria Schwarz, Ingrid Kindermann, Reinhard Kandolf, Martina Sauter, Christian Ukena, Ali Yilmaz, Karen Sliwa, Claus-Thomas Bock, Karin Klingel, Michael Böhm
BACKGROUND: Diagnosis of viral myocarditis is difficult by clinical criteria but facilitated by detection of inflammation and viral genomes in endomyocardial biopsies. Parvovirus B19 (B19V) targets endothelial cells where viral nucleic acid is exclusively detected in the heart. Microparticles (MPs) are released after cell damage or activation of specific cells. We aimed to investigate whether circulating endothelial MPs (EMPs) in human and experimental models of myocarditis are associated with B19V myocarditis...
2017: PloS One
https://www.readbyqxmd.com/read/28512588/severe-aplastic-anemia-following-parvovirus-b19-associated-acute-hepatitis
#3
Masanori Furukawa, Kosuke Kaji, Hiroyuki Masuda, Kuniaki Ozaki, Shohei Asada, Aritoshi Koizumi, Takuya Kubo, Norihisa Nishimura, Yasuhiko Sawada, Kosuke Takeda, Tsuyoshi Mashitani, Masayuki Kubo, Itsuto Amano, Tomoyuki Ootani, Chiho Ohbayashi, Koji Murata, Tatsuichi Ann, Akira Mitoro, Hitoshi Yoshiji
Human parvovirus (HPV) B19 is linked to a variety of clinical manifestations, such as erythema infectiosum, nonimmune hydrops fetalis, and transient aplastic anemia. Although a few cases have shown HPVB19 infection as a possible causative agent for hepatitis-associated aplastic anemia (HAAA) in immunocompetent patients, most reported cases of HAAA following transient hepatitis did not have delayed remission. Here we report a rare case of severe aplastic anemia following acute hepatitis with prolonged jaundice due to HPVB19 infection in a previously healthy young male...
2017: Case Reports in Hepatology
https://www.readbyqxmd.com/read/28500881/a-parvovirus-b19-synthetic-genome-sequence-features-and-functional-competence
#4
Elisabetta Manaresi, Ilaria Conti, Gloria Bua, Francesca Bonvicini, Giorgio Gallinella
Central to genetic studies for Parvovirus B19 (B19V) is the availability of genomic clones that may possess functional competence and ability to generate infectious virus. In our study, we established a new model genetic system for Parvovirus B19. A synthetic approach was followed, by design of a reference genome sequence, by generation of a corresponding artificial construct and its molecular cloning in a complete and functional form, and by setup of an efficient strategy to generate infectious virus, via transfection in UT7/EpoS1 cells and amplification in erythroid progenitor cells...
May 10, 2017: Virology
https://www.readbyqxmd.com/read/28489127/genotype-1-of-human-parvovirus-b19-in-clinical-cases
#5
Maria Isabel de Oliveira, Ana Maria Sardinha Afonso, Suely Pires Curti, Patrícia Evelin Silva, Tamyris Fernanda Barbosa, Elian Reis Silva, Cristina Adelaide Figueiredo
Introduction: Virus surveillance strategies and genetic characterization of human parvovirus B19 (B19V) are important tools for regional and global control of viral outbreak. In São Paulo, Brazil, we performed a study of B19V by monitoring the spread of this virus, which is an infectious agent and could be mistakenly reported as a rash and other types of infection. Method: Serum samples were subjected to enzyme immunoassay, real time polymerase chain reaction, and sequencing...
March 2017: Revista da Associação Médica Brasileira
https://www.readbyqxmd.com/read/28459842/phosphorylated-stat5-directly-facilitates-parvovirus-b19-dna-replication-in-human-erythroid-progenitors-through-interaction-with-the-mcm-complex
#6
Safder S Ganaie, Wei Zou, Peng Xu, Xuefeng Deng, Steve Kleiboeker, Jianming Qiu
Productive infection of human parvovirus B19 (B19V) exhibits high tropism for burst forming unit erythroid (BFU-E) and colony forming unit erythroid (CFU-E) progenitor cells in human bone marrow and fetal liver. This exclusive restriction of the virus replication to human erythroid progenitor cells is partly due to the intracellular factors that are essential for viral DNA replication, including erythropoietin signaling. Efficient B19V replication also requires hypoxic conditions, which upregulate the signal transducer and activator of transcription 5 (STAT5) pathway, and phosphorylated STAT5 is essential for virus replication...
May 2017: PLoS Pathogens
https://www.readbyqxmd.com/read/28459015/falciparum-malaria-and-parvovirus-b19-coinfection-a-rare-entity
#7
Rakesh Agarwal, Rashmi Baid, Rajarshi Datta, Manjari Saha, Nirmalendu Sarkar
No abstract text is available yet for this article.
January 2017: Tropical Parasitology
https://www.readbyqxmd.com/read/28412176/human-parvovirus-b19-nosocomial-outbreak-in-healthcare-personnel-in-a-paediatric-ward-at-a-national-tertiary-referral-centre-in-thailand
#8
S Sungkate, W Phongsamart, S Rungmaitree, K Lapphra, O Wittawatmongkol, V Pumsuwan, N Wiruchkul, S Assanasen, Y Rongrungruang, N Onlamoon, N Horthongkham, W Lermankul, N Kongstan, K Chokephaibulkit
BACKGROUND: Nosocomial outbreaks of parvovirus B19 (pB19) have been reported, but they rarely occur among healthcare personnel (HCP). Susceptibility among pregnant HCP was the major concern. METHODS: An outbreak of pB19 among HCP is described in a paediatric ward with a cross-sectional serologic study in all HCP and patients exposed to the outbreak. Acute infection was diagnosed by polymerase chain reaction or positive anti-parvovirus B19 IgM. FINDINGS: Among 48 HCP (three pregnant) and 22 patients included in the outbreak serologic study, 11 (23%) HCP and two (9%) patients had acute infection...
March 18, 2017: Journal of Hospital Infection
https://www.readbyqxmd.com/read/28410597/the-role-of-nuclear-localization-signal-in-parvovirus-life-cycle
#9
REVIEW
Peng Liu, Shun Chen, Mingshu Wang, Anchun Cheng
Parvoviruses are small, non-enveloped viruses with an approximately 5.0 kb, single-stranded DNA genome. Usually, the parvovirus capsid gene contains one or more nuclear localization signals (NLSs), which are required for guiding the virus particle into the nucleus through the nuclear pore. However, several classical NLSs (cNLSs) and non-classical NLSs (ncNLSs) have been identified in non-structural genes, and the ncNLSs can also target non-structural proteins into the nucleus. In this review, we have summarized recent research findings on parvovirus NLSs...
April 14, 2017: Virology Journal
https://www.readbyqxmd.com/read/28403966/-intrauterine-blood-transfusion-status-report-of-4years-of-practice-in-france-2011-2014
#10
A Girault, S Friszer, E Maisonneuve, L Guilbaud, A Cortey, J-M Jouannic
OBJECTIVES: The aim of our study was to evaluate in utero blood transfusion's (IUT) performed in France, among the French prenatal diagnosis centers in order to study the etiology of severe anemia requiring IUT. METHODS: We conducted a national retrospective descriptive study between 2011 and 2014. The data were collected using a survey sent by email to all French prenatal diagnosis centers. RESULTS: Among the 49 centers, 18 (38 %) had performed at least one IUT during the study period...
February 2017: J Gynecol Obstet Hum Reprod
https://www.readbyqxmd.com/read/28401102/human-parvovirus-b19-in-patients-with-beta-thalassemia-major-from-tehran-iran
#11
Seyed Ali Mohammad Arabzadeh, Farideh Alizadeh, Ahmad Tavakoli, Hamidreza Mollaei, Farah Bokharaei-Salim, Gharib Karimi, Mohammad Farahmand, Helya Sadat Mortazavi, Seyed Hamidreza Monavari
BACKGROUND: Due to the tropism of human parvovirus B19 to erythroid progenitor cells, infection in patients with an underlying hemolytic disorder such as beta-thalassemia major leads to suppression of erythrocyte formation, referred to as transient aplasia crisis (TAC), which may be life-threatening. We investigated the prevalence of parvovirus B19 among patients with beta thalassemia major attending the Zafar Adult Thalassemia Clinic in Tehran, Iran. METHODS: This cross-sectional study was performed to determine the presence of parvovirus B19 DNA in blood samples and parvovirus B19 genotypes in plasma samples of patients with thalassemia major...
March 2017: Blood Research
https://www.readbyqxmd.com/read/28398685/parvovirus-b19-infection-during-pregnancy-and-risks-to-the-fetus
#12
REVIEW
Asher Ornoy, Zivanit Ergaz
Parvovirus B19 infects 1 to 5% of pregnant women, generally with normal pregnancy outcomes. During epidemics, the rate of infection is higher. Major congenital anomalies among offspring of infected mothers are rare, as the virus does not appear to be a significant teratogen. However, parvovirus B19 infection may cause significant fetal damage, and in rare cases, brain anomalies and neurodevelopmental insults, especially if infection occurs in the first 20 weeks of pregnancy. Parvovirus B19 is also an important cause of fetal loss, especially in the second half of pregnancy when spontaneous fetal loss from other causes is relatively rare...
March 15, 2017: Birth Defects Res
https://www.readbyqxmd.com/read/28397477/real-time-pcr-detection-of-the-most-common-bacteria-and-viruses-causing-meningitis
#13
Oya Akkaya, Hulya Iren Guvenc, Serife Yuksekkaya, Aysegul Opus, Asuman Guzelant, Meral Kaya, Muhammet Guzel Kurtoglu, Nurettin Kaya
BACKGROUND: Central nervous system (CNS) infections require prompt diagnosis, as the clinical condition progresses rapidly and may lead to severe permanent sequelae or death. The causative agents include viruses, bacteria, fungi, and parasites. In this study, samples with the diagnosis of CNS infection based on cerebrospinal fluid (CSF) sent to us from other hospitals/labs, were studied by multiplex real-time Polymerase Chain Reaction (PCR) method. The purpose of this study is to demonstrate, retrospectively, the most common bacteria and viruses causing meningitis and seasonal distribution of these agents using the multiplex real-time PCR method in CSF samples...
April 1, 2017: Clinical Laboratory
https://www.readbyqxmd.com/read/28387173/pure-red-cell-aplasia-due-to-parvovirus-b19-erythropoietin-resistant-anemia-in-a-pediatric-kidney-recipient
#14
Baris Malbora, Serdar Saritas, Eda Ataseven, Burcu Belen, Caner Alparslan, Onder Yavascan, Dilek Yilmaz Ciftdogan, Berna Atabay, Meral Turker
No abstract text is available yet for this article.
April 6, 2017: Experimental and Clinical Transplantation
https://www.readbyqxmd.com/read/28377277/hydroxyurea-inhibits-parvovirus-b19-replication-in-erythroid-progenitor-cells
#15
Francesca Bonvicini, Gloria Bua, Ilaria Conti, Elisabetta Manaresi, Giorgio Gallinella
Parvovirus B19 (B19V) infection is restricted to erythroid progenitor cells (EPCs) of the human bone marrow, leading to transient arrest of erythropoiesis and severe complications mainly in subjects with underlying hematological disorders or with immune system deficits. Currently, there are no specific antiviral drugs for B19V treatment, but identification of compounds inhibiting B19V replication can be pursued by a drug repositioning strategy. In this frame, the present study investigates the activity of hydroxyurea (HU), the only disease-modifying therapy approved for sickle cell disease (SCD), towards B19V replication in the two relevant cellular systems, the UT7/EpoS1 cell line and EPCs...
April 2, 2017: Biochemical Pharmacology
https://www.readbyqxmd.com/read/28374737/extinct-type-of-human-parvovirus-b19-persists-in-tonsillar-b-cells
#16
Lari Pyöriä, Mari Toppinen, Elina Mäntylä, Lea Hedman, Leena-Maija Aaltonen, Maija Vihinen-Ranta, Taru Ilmarinen, Maria Söderlund-Venermo, Klaus Hedman, Maria F Perdomo
Parvovirus B19 (B19V) DNA persists lifelong in human tissues, but the cell type harbouring it remains unclear. We here explore B19V DNA distribution in B, T and monocyte cell lineages of recently excised tonsillar tissues from 77 individuals with an age range of 2-69 years. We show that B19V DNA is most frequent and abundant among B cells, and within them we find a B19V genotype that vanished from circulation >40 years ago. Since re-infection or re-activation are unlikely with this virus type, this finding supports the maintenance of pathogen-specific humoral immune responses as a consequence of B-cell long-term survival rather than continuous replenishment of the memory pool...
April 4, 2017: Nature Communications
https://www.readbyqxmd.com/read/28373861/environmental-issues-in-thyroid-diseases
#17
REVIEW
Silvia Martina Ferrari, Poupak Fallahi, Alessandro Antonelli, Salvatore Benvenga
Environmental factors are determinant for the appearance of autoimmune thyroid diseases (AITD) in susceptible subjects. Increased iodine intake, selenium, and vitamin D deficiency, exposure to radiation, from nuclear fallout or due to medical radiation, are environmental factors increasing AITD. Cigarette smoking is associated with Graves' disease and Graves' ophthalmopathy, while it decreases the risk of hypothyroidism and thyroid autoimmunity. Viral infections are important environmental factors in the pathogenesis of AITD, too, particularly human parvovirus B19 (EVB19) and hepatitis C virus...
2017: Frontiers in Endocrinology
https://www.readbyqxmd.com/read/28369973/persistent-symptomatic-parvovirus-b19-infection-with-severe-thrombocytopenia-transmitted-by-red-blood-cell-transfusion-containing-low-parvovirus-b19-dna-levels
#18
Keiki Nagaharu, Yuka Sugimoto, Yuji Hoshi, Takanori Yamaguchi, Ryugo Ito, Keiji Matsubayashi, Keiki Kawakami, Kohshi Ohishi
BACKGROUND: Transfusion-mediated human parvovirus B19 (PVB19) infection is rare but often causes severe hematologic disorders. In Japan, routine blood donor screening for PVB19 antigen (detection sensitivity, 10(6.4) IU/mL) using a chemiluminescent enzyme immunoassay (CLEIA) was introduced in 2008. However, there is no consensus on the minimal infectious dose of PVB19 permissible for red blood cells (RBCs). CASE REPORT: A 64-year-old man, who had received hemodialysis for diabetic nephropathy for 5 years, underwent an RBC transfusion for anemia caused by hemorrhagic enterocolitis...
April 2, 2017: Transfusion
https://www.readbyqxmd.com/read/28366188/corrigendum-the-plasma-virome-of-febrile-adult-kenyans-shows-frequent-parvovirus-b19-infections-and-a-novel-arbovirus-kadipiro-virus
#19
Carolyne N Ngoi, Juliana Siqueira, Linlin Li, Xutao Deng, Peter Mugo, Susan M Graham, Matt A Price, Eduard J Sanders, Eric Delwart
No abstract text is available yet for this article.
March 2017: Journal of General Virology
https://www.readbyqxmd.com/read/28358698/increased-numbers-of-cd4-cd25-and-cd8-cd25-t-cells-in-peripheral-blood-of-patients-with-rheumatoid-arthritis-with-parvovirus-b19-infection
#20
Milda Naciute, Gabriele Maciunaite, Diana Mieliauskaite, Rita Rugiene, Aukse Zinkeviciene, Mykolas Mauricas, Modra Murovska, Irute Girkontaite
AIM: To investigate T-cell subpopulations in peripheral blood of human parvovirus B19 DNA-positive (B19(+)) and -negative (B19(-)) patients with rheumatoid arthritis (RA) and healthy persons. PATIENTS AND METHODS: Blood samples were collected from 115 patients with RA and 47 healthy volunteers; 27 patients with RA and nine controls were B19(+) Cluster of differentiation (CD) 4, 8, 25 and 45RA were analyzed on blood cells. CD25 expression on CD4(+)CD45RA(+), CD4(+)CD45RA(-), CD8(+)CD45RA(+), CD8(+)CD45RA(-) subsets were analyzed by flow cytometry...
March 2017: In Vivo
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