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https://www.readbyqxmd.com/read/27914549/age-of-fusion-of-the-distal-radial-and-ulnar-epiphyses-from-hand-radiographs-a-study-in-kashmiri-population
#1
Nida Hassan, Farida Noor, Shabir Ahmad, Khalid Majid Fazili
Age estimation is a crucial parameter involved in investigations pertaining to civil and criminal procedures. It also aids in various examinations in forensic medicine, pediatrics, endocrinology and radiology. One of the important methods for skeletal age estimation is the age of fusion of the epiphyses. But there occur variations in the skeletal ages due to environmental, hormonal, ethnic and other factors. Hence, there arises the need for separate standards of ossification for different regions. The present study was conducted to ascertain the age of fusion of the distal radial and ulnar epiphyses in Kashmiri population...
December 2016: Science & Justice: Journal of the Forensic Science Society
https://www.readbyqxmd.com/read/27906195/congenital-hypothyroidism-with-delayed-thyroid-stimulating-hormone-elevation-in-premature-infants-born-at-less-than-30-weeks-gestation
#2
D C Kaluarachchi, T T Colaizy, L M Pesce, M Tansey, J M Klein
OBJECTIVE: Congenital hypothyroidism (CH) with delayed thyroid-stimulating hormone (TSH) elevation is a common form of thyroid dysfunction among premature infants. Routine newborn screening (NBS) may miss infants with CH with delayed TSH elevation. The objective of the study is to determine the prevalence of CH with delayed TSH elevation in premature infants and to identify associated risk factors. STUDY DESIGN: Retrospective analysis of serum thyroid function screening (TFS) at day of life 30 in premature infants <30 weeks gestation, admitted to University of Iowa Neonatal Intensive Care Unit between 1 July 2012 to 30 June 2015...
December 1, 2016: Journal of Perinatology: Official Journal of the California Perinatal Association
https://www.readbyqxmd.com/read/27888003/small-non-coding-rnas-based-bone-regulation-and-targeting-therapeutic-strategies
#3
Ying Yang, Sijie Fang
Small non-coding RNAs, which are 20-25 nucleotide ribonucleic acids, have emerged as an important transformation in the biological evolution over almost three decades. microRNAs (miRNAs) and short interfering RNAs (siRNAs) are two significant categories of the small RNAs that exert important effects on bone endocrinology and skeletology. Therefore, clarifying the expression and function of these important molecules in bone endocrine physiology and pathology is of great significance for improving their potential therapeutic value for metabolism-associated bone diseases...
November 23, 2016: Molecular and Cellular Endocrinology
https://www.readbyqxmd.com/read/27881753/how-can-we-estimate-natural-selection-on-endocrine-traits-lessons-from-evolutionary-biology
#4
REVIEW
Frances Bonier, Paul R Martin
An evolutionary perspective can enrich almost any endeavour in biology, providing a deeper understanding of the variation we see in nature. To this end, evolutionary endocrinologists seek to describe the fitness consequences of variation in endocrine traits. Much of the recent work in our field, however, follows a flawed approach to the study of how selection shapes endocrine traits. Briefly, this approach relies on among-individual correlations between endocrine phenotypes (often circulating hormone levels) and fitness metrics to estimate selection on those endocrine traits...
November 30, 2016: Proceedings. Biological Sciences
https://www.readbyqxmd.com/read/27814885/introducing-the-microbiome-into-precision-medicine
#5
REVIEW
Thomas M Kuntz, Jack A Gilbert
Understanding how individual people respond to medical therapy is a key facet of improving the odds ratio that interventions will have a positive impact. Reducing the non-responder rate for an intervention or reducing complications associated with a particular treatment or surgery is the next stage of medical advance. The Precision Medicine Initiative, launched in January 2015, set the stage for enhanced collaboration between researchers and medical professionals to develop next-generation techniques to aid patient treatment and recovery, and increased the opportunities for impactful pre-emptive care...
October 25, 2016: Trends in Pharmacological Sciences
https://www.readbyqxmd.com/read/27760420/risks-of-metformin-in-type-2-diabetes-and-chronic-kidney-disease-lessons-learned-from-taiwanese-data
#6
Connie M Rhee, Csaba P Kovesdy, Kamyar Kalantar-Zadeh
Like other biguanide agents, metformin is an anti-hyperglycemic agent with lower tendency towards hypoglycemia compared to other anti-diabetic drugs. Given its favorable effects on serum lipids, obese body habitus, cardiovascular disease, and mortality, metformin is recommended as the first-line pharmacologic agent for type 2 diabetes in the absence of contraindications. However, as metformin accumulation may lead to type B non-hypoxemic lactic acidosis, especially in the setting of kidney injury, chronic kidney disease, and overdose, regulatory agencies such as the United States Food and Drug Administration (FDA) have maintained certain restrictions regarding its use in kidney dysfunction...
October 20, 2016: Nephron
https://www.readbyqxmd.com/read/27730065/voice-and-endocrinology
#7
K V S Hari Kumar, Anurag Garg, N S Ajai Chandra, S P Singh, Rakesh Datta
Voice is one of the advanced features of natural evolution that differentiates human beings from other primates. The human voice is capable of conveying the thoughts into spoken words along with a subtle emotion to the tone. This extraordinary character of the voice in expressing multiple emotions is the gift of God to the human beings and helps in effective interpersonal communication. Voice generation involves close interaction between cerebral signals and the peripheral apparatus consisting of the larynx, vocal cords, and trachea...
September 2016: Indian Journal of Endocrinology and Metabolism
https://www.readbyqxmd.com/read/27710986/the-epidemiology-of-pituitary-adenomas-in-a-community-based-hospital-a-retrospective-single-center-study-in-saudi-arabia
#8
Khalid S Aljabri, Samia A Bokhari, Faisal Y Assiri, Muneera A Alshareef, Patan M Khan
BACKGROUND: Data on pituitary adenoma (PA) prevalence in Saudi Arabia are scarce. OBJECTIVE: To estimate the epidemiology of PA in a well-defined population. DESIGN: Retrospective analysis. SETTING: Departments of Endocrinology and Radiology at King Fahad Armed Forces Hospital, Jeddah, Saudi Arabia. PATIENTS AND METHODS: Radiological and hormonal data of patients with pituitary adenoma by MRI were reviewed for the period January 2008 to December 2015...
September 2016: Annals of Saudi Medicine
https://www.readbyqxmd.com/read/27704399/consensus-on-the-management-of-advanced-radioactive-iodine-refractory-differentiated-thyroid-cancer-on-behalf-of-the-spanish-society-of-endocrinology-thyroid-cancer-working-group-gtseen-and-spanish-rare-cancer-working-group-gethi
#9
J Capdevila, J C Galofré, E Grande, C Zafón Llopis, T Ramón Y Cajal Asensio, E Navarro González, P Jiménez-Fonseca, J Santamaría Sandi, J M Gómez Sáez, G Riesco Eizaguirre
Thyroid cancer is the single most prevalent endocrine malignancy; differentiated thyroid cancer (DTC) accounts for more than 90 % of all malignancies and its incidence has been rising steadily. For more patients, surgical treatment, radioactive iodine (RAI) ablation, and thyroid-stimulating hormone (TSH) suppressive therapy achieve an overall survival (OS) rate of 97.7 % at 5 years. Nevertheless, locoregional recurrence occurs in up to 20 % and distant metastases in approximately 10 % at 10 years. Two-thirds of these patients will never be cured with radioactive iodine therapy and will become RAI-refractory, with a 3-year OS rate of less than 50 %...
October 4, 2016: Clinical & Translational Oncology
https://www.readbyqxmd.com/read/27691051/career-advancement-meeting-the-challenges-confronting-the-next-generation-of-endocrinologists-and-endocrine-researchers
#10
Richard J Santen, Anju Joham, Lauren Fishbein, Kristen R Vella, Peter R Ebeling, Melanie Gibson-Helm, Helena Teede
CONTEXT: Challenges and opportunities face the next generation (Next-Gen) of endocrine researchers and clinicians, the lifeblood of the field of endocrinology for the future. A symposium jointly sponsored by the Endocrine Society and the Endocrine Society of Australia was convened to discuss approaches to addressing present and future Next-Gen needs. EVIDENCE ACQUISITION: Data collection by literature review, assessment of previously completed questionnaires, commissioning of a new questionnaire, and summarization of symposium discussions...
October 3, 2016: Journal of Clinical Endocrinology and Metabolism
https://www.readbyqxmd.com/read/27566421/progress-in-pediatrics-in-2015-choices-in-allergy-endocrinology-gastroenterology-genetics-haematology-infectious-diseases-neonatology-nephrology-neurology-nutrition-oncology-and-pulmonology
#11
EDITORIAL
Carlo Caffarelli, Francesca Santamaria, Dora Di Mauro, Carla Mastrorilli, Virginia Mirra, Sergio Bernasconi
This review focuses key advances in different pediatric fields that were published in Italian Journal of Pediatrics and in international journals in 2015. Weaning studies continue to show promise for preventing food allergy. New diagnostic tools are available for identifying the allergic origin of allergic-like symptoms. Advances have been reported in obesity, short stature and autoimmune endocrine disorders. New molecules are offered to reduce weight gain and insulin-resistance in obese children. Regional investigations may provide suggestions for preventing short stature...
August 27, 2016: Italian Journal of Pediatrics
https://www.readbyqxmd.com/read/27537245/glycated-albumin-and-ratio-of-glycated-albumin-to-hemoglobin-are-good-indicators-of-diabetic-nephropathy-in-type-2-diabetes-mellitus
#12
Nana Wang, Zhen Xu, Ping Han, Tiegang Li
BACKGROUND: We investigated the association between serum levels of glycated albumin (GA), glycated hemoglobin (HbA1c) and GA/HbA1c ratio and the presence of diabetic nephropathy (DN) in patients with type 2 diabetes mellitus (T2DM). METHODS: 206 consecutive patients with T2DM were enrolled from the endocrinology ward at Shengjing Hospital of the China Medical University, and classified into two groups: DN group (n =71) and diabetic non-nephropathy (non-DN) group (n = 135)...
August 18, 2016: Diabetes/metabolism Research and Reviews
https://www.readbyqxmd.com/read/27446925/personalized-medicine-in-cerebrovascular-neurosurgery-precision-neurosurgical-management-of-cerebral-aneurysms-and-subarachnoid-hemorrhage
#13
REVIEW
Achal Singh Achrol, Gary K Steinberg
Cerebral aneurysms are common vascular lesions. Little is known about the pathogenesis of these lesions and the process by which they destabilize and progress to rupture. Treatment decisions are motivated by a desire to prevent rupture and the devastating morbidity and mortality associated with resulting subarachnoid hemorrhage (SAH). For patients presenting with SAH, urgent intervention is required to stabilize the lesion and prevent re-rupture. Those patients fortunate enough to survive a presenting SAH and subsequent securing of their aneurysm must still face a spectrum of secondary sequelae, which can include cerebral vasospasm, delayed ischemia, seizures, cerebral edema, hydrocephalus, and endocrinologic and catecholamine-induced systemic dysfunction in cardiac, pulmonary, and renal systems...
2016: Frontiers in Surgery
https://www.readbyqxmd.com/read/27440480/nivolumab-induced-hypophysitis-in-a-patient-with-advanced-malignant-melanoma
#14
Yudai Okano, Tetsurou Satoh, Kazuhiko Horiguchi, Minoru Toyoda, Aya Osaki, Shunichi Matsumoto, Takuya Tomaru, Yasuyo Nakajima, Sumiyasu Ishii, Atsushi Ozawa, Nobuyuki Shibusawa, Takehiro Shimada, Tetsuya Higuchi, Kazuaki Chikamatsu, Masanobu Yamada
The anti-programmed cell death-1 monoclonal antibody (mab), nivolumab has recently been approved for the treatment of unresectable or metastatic malignant melanoma and non-small-cell lung cancers in Japan. Ipilimumab, an anti-cytotoxic T lymphocyte antigen-4 mab for malignant melanoma that was approved earlier than nivolumab in Western countries, is known to frequently cause endocrine immune-related adverse events such as hypophysitis and thyroid dysfunction. We herein report a patient with advanced melanoma who appeared to develop hypophysitis as a consequence of the inhibition of PD-1 by nivolumab...
October 29, 2016: Endocrine Journal
https://www.readbyqxmd.com/read/27387241/determination-of-advanced-glycation-end-products-and-antibodies-against-them-anti-cml-and-anti-cel-in-the-serum-of-graves-orbitopathy-patients-before-and-after-methylprednisolone-treatment
#15
Janusz Strzelczyk, Magdalena Szumska, Aleksandra Damasiewicz-Bodzek, Anna Krywult, Michał Długaszek, Justyna Czubilińska, Kaja Gawlik, Konrad Synowiec, Krystyna Tyrpień-Golder, Karolina Poczkaj, Beata Kos-Kudła
INTRODUCTION: The glycation process is a non-enzymatic modification of proteins occurring due to the reactions of reductive carbohydrates. The glycated residues lose their biological functions, and their removal process is ineffective. They accumulate, and as a result they cause an immunological response. The aim of this study was a determination of the concentrations of advanced glycation end-products and antibodies against carboxymethyl lysine (anti-CML) and carboxyethyl lysine (anti-CEL) in the sera of Graves' orbitopathy patients...
2016: Endokrynologia Polska
https://www.readbyqxmd.com/read/27367219/effectiveness-of-shared-medical-appointments-versus-traditional-clinic-visits-for-adolescents-with-type-1-diabetes
#16
Erica Everest, Sara Akhtar, Marianne Sumego, Alaa Zeizoun, Sarah Worley, Anne S Tang, Allison Dorsey, Ann Smith, Bahareh Schweiger
Shared medical appointments began in the United States in 1996 to advance quality of care and enhance patients' ability to self-manage. Group visits gather patients with the same diagnosis for individual examinations followed by group education sessions taught by the provider. This leads to the opportunity to learn from the experiences of others. The Cleveland Clinic Department of Pediatric Endocrinology offers a shared medical appointment group for pediatric patients with type 1 diabetes called the ESCALAIT clinic (Enrichment Services and Care for Adolescents Living with Autoimmune Insulin Dependent Type 1 Diabetes)...
July 2016: Quality Management in Health Care
https://www.readbyqxmd.com/read/27318276/ancient-origins-of-metazoan-gonadotropin-releasing-hormone-and-their-receptors-revealed-by-phylogenomic-analyses
#17
David C Plachetzki, Pei-San Tsai, Scott I Kavanaugh, Stacia A Sower
The discovery of genes related to gonadotropin-releasing hormones (GnRH) and their receptors from diverse species has driven important advances in comparative endocrinology. However, our view of the evolutionary histories and nomenclature of these gene families has become inconsistent as several different iterations of GnRH and receptor relationships have been proposed. Whole genome sequence data are now available for most of the major lineages of animals, and an exhaustive view of the phylogenies of GnRH and their receptors is now possible...
August 1, 2016: General and Comparative Endocrinology
https://www.readbyqxmd.com/read/27306911/immune-checkpoint-inhibitors-review-and-management-of-endocrine-adverse-events
#18
REVIEW
Elisa González-Rodríguez, Delvys Rodríguez-Abreu
UNLABELLED: : In recent years, immune checkpoint inhibitors have emerged as effective therapies for advanced neoplasias. As new checkpoint target blockers become available and additional tumor locations tested, their use is expected to increase within a short time. Immune-related adverse events (irAEs) affecting the endocrine system are among the most frequent and complex toxicities. Some may be life-threatening if not recognized; hence, appropriate guidance for oncologists is needed...
July 2016: Oncologist
https://www.readbyqxmd.com/read/27306034/the-realization-of-the-brain-gut-interactions-with-corticotropin-releasing-factor-and-glucocorticoids
#19
Ludmila Filaretova, Tatiana Bagaeva
The brain and the gut interact bi-directionally through the brain-gut axis. The interaction is mediated by of the autonomic nervous system and by the hypothalamic-pituitary-adrenocortical (HPA) system. The first brilliant demonstration of the brain-gut interactions was the cephalic phase of gastric and pancreatic secretion followed later by further brilliant demonstration, namely a conditional reflex, both discovered by Ivan Pavlov, the first physiologist who was awarded the Nobel Prize for Physiology or Medicine in 1904...
June 13, 2016: Current Neuropharmacology
https://www.readbyqxmd.com/read/27256226/-characterization-of-ovarian-adrenal-rest-tumors-in-children-and-adolescent-females-with-congenital-adrenal-hyperplasia-due-to-21-hydroxylase-deficiency
#20
Z Su, Y Y Li, H M Ma, J Zhang, M L Du
OBJECTIVE: To summarize the characterization of ovarian adrenal rest tumors (OART) in children and adolescent females with congenital adrenal hyperplasia (CAH) due to 21-hydroxylase deficiency (21-OHD). METHOD: We have diagnosed 4 cases of CAH 21-OHD with OART in the recent 5 years in pediatric endocrinology unit of the first affiliated hospital of Sun Yat-Sen University. Clinical characterizations were summarized, including symptoms, growth patterns and bone age advancements, serum steroid concentrations, imaging results and the follow-up data...
June 2, 2016: Zhonghua Er Ke za Zhi. Chinese Journal of Pediatrics
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