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Surgery obesity

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https://www.readbyqxmd.com/read/29243457/the-surgical-management-of-obesity
#1
Samuel Torres-Landa, Umashankkar Kannan, Isabella Guajardo, Octavia E Pickett-Blakely, Daniel T Dempsey, Noel N Williams, Kristoffel R Dumon
Obesity is a spreading epidemic associated with significant morbidity and mortality with a prevalence of over 36% worldwide. In the face of a growing epidemic, increasing medical costs, and the disappointing limitations of medical and lifestyle modification bariatric surgery was found to consistently lead to significant weight loss and improvement in obesity-associated comorbidities when compared to non-surgical interventions. Bariatric procedures fall within three basic categories: restrictive procedures, malabsorptive procedures, and procedures that combine both restrictive and malabsorptive mechanisms...
December 14, 2017: Minerva Chirurgica
https://www.readbyqxmd.com/read/29243396/bariatric-surgery-induced-cardiac-and-lipidomic-changes-in-obesity-related-heart-failure-with-preserved-ejection-fraction
#2
Deana Mikhalkova, Sujata R Holman, Hui Jiang, Mohammed Saghir, Eric Novak, Andrew R Coggan, Robert O'Connor, Adil Bashir, Ali Jamal, Daniel S Ory, Jean E Schaffer, J Christopher Eagon, Linda R Peterson
OBJECTIVE: To determine the effects of gastric bypass on myocardial lipid deposition and function and the plasma lipidome in women with obesity and heart failure with preserved ejection fraction (HFpEF). METHODS: A primary cohort (N = 12) with HFpEF and obesity underwent echocardiography and magnetic resonance spectroscopy both before and 3 months and 6 months after bariatric surgery. Plasma lipidomic analysis was performed before surgery and 3 months after surgery in the primary cohort and were confirmed in a validation cohort (N = 22)...
December 15, 2017: Obesity
https://www.readbyqxmd.com/read/29242649/dose-reversal-effect-relationship-of-three-different-doses-of-neostigmine-in-obese-patients-a-randomised-clinical-trial
#3
Satyen Parida, Venkatesan Kausalya, Sandeep Kumar Mishra, Sethuramachandran Adinarayanan
Background and Aims: Previous studies suggest that administration of vecuronium based on total body weight rather than ideal body weight (IBW) in obesity results in overdosing with prolonged recovery times. We hypothesised that larger doses of neostigmine could result in faster recovery in obese patients administered vecuronium based on total body weight. Methods: Forty-five obese American Society of Anesthesiologists' II patients undergoing elective surgery under general anaesthesia were randomised into 3 groups to receive neostigmine 30, 40 and 50 μg/kg...
October 2017: Indian Journal of Anaesthesia
https://www.readbyqxmd.com/read/29242563/ck2-modulates-adipocyte-insulin-signaling-and-is-up-regulated-in-human-obesity
#4
Christian Borgo, Gabriella Milan, Francesca Favaretto, Fabio Stasi, Roberto Fabris, Valentina Salizzato, Luca Cesaro, Anna Belligoli, Marta Sanna, Mirto Foletto, Luca Prevedello, Vincenzo Vindigni, Romeo Bardini, Arianna Donella-Deana, Roberto Vettor
Insulin plays a major role in glucose metabolism and insulin-signaling defects are present in obesity and diabetes. CK2 is a pleiotropic protein kinase implicated in fundamental cellular pathways and abnormally elevated in tumors. Here we report that in human and murine adipocytes CK2-inhibition decreases the insulin-induced glucose-uptake by counteracting Akt-signaling and GLUT4-translocation to the plasma membrane. In mice CK2 acts on insulin-signaling in adipose tissue, liver and skeletal muscle and its acute inhibition impairs glucose tolerance...
December 14, 2017: Scientific Reports
https://www.readbyqxmd.com/read/29239795/effects-of-very-low-calorie-diets-on-liver-size-and-weight-loss-in-the-preoperative-period-of-bariatric-surgery-a-systematic-review
#5
REVIEW
Mariana Holderbaum, Daniela Schaan Casagrande, Samanta Sussenbach, Caroline Buss
Restrictive diet implementation in bariatric surgery (BS) preoperative period is common, although its benefits are not well established. This study aimed to assess the effects of very low calorie diets (VLCD) on liver size and weight loss during BS preoperative period. Surgery-related complications were also assessed. A systematic review of the literature was performed. Terms such as "bariatric surgery" and "very low energy diet" were included in the search strategy. Inclusion criteria were adult patients (aged>18 yr); VLCD treatment in BS preoperative period (10 d to 12 wk); and assessment of 1 the following outcomes: weight loss, liver volume reduction, and surgical complications...
October 2, 2017: Surgery for Obesity and related Diseases: Official Journal of the American Society for Bariatric Surgery
https://www.readbyqxmd.com/read/29239576/living-donor-kidney-transplantation
#6
Ilkka Helanterä, Eero Honkanen, Jutta Huhti, Helena Isoniemi, Hannu Jalanko, Marko Lempinen, Marja Miettinen, Arno Nordin, Risto Tertti, Satu Mäkelä
While the majority of kidney transplantations in Finland have been traditionally performed from deceased donors, the frequency of living donors should be increased. Kidney donation is a safe procedure for a carefully examined donor, and for the recipient living donation enables elective surgery and preemptive transplantation. Potential risks for the donor must be minimized, but according to current recommendations, mild hypertension or obesity are not absolute contraindications for donation. Guidelines for donor selection and examination have been updated to simplify the process for all parties...
2017: Duodecim; Lääketieteellinen Aikakauskirja
https://www.readbyqxmd.com/read/29239469/bariatric-surgery-in-the-elderly-a-narrative-review
#7
Everton Cazzo, Martinho Antonio Gestic, Murillo Pimentel Utrini, Felipe David Mendonça Chaim, Francisco Callejas-Neto, José Carlos Pareja, Elinton Adami Chaim
INTRODUCTION: Due to population ageing, the elderly obese population is increasing. Bariatric surgery is the standard treatment option for morbid obesity nowadays, but there is some controversy regarding its routine indication in the elderly population. Objetive: To review the current evidence about bariatric surgery in the elderly. METHOD: On-line search in the electronic databases Medline and Lilacs and compilation of the most significant data. The most relevant studies in the area over the past 16 years have been considered for this review...
September 2017: Revista da Associação Médica Brasileira
https://www.readbyqxmd.com/read/29239284/maternal-obesity-and-excessive-maternal-weight-gain-during-pregnancy-effects-on-outcomes-after-neonatal-cardiac-surgical-procedures
#8
Rocky Tsang, Pamela Hilvers, Philip J Lupo, Ronald Bronicki, Dean McKenzie, Paul A Checchia
Introduction Maternal obesity is associated with an increased risk for adverse perinatal outcomes. Obesity is also associated with a chronic inflammatory state and metabolic derangements that affect the newborn. The additional use of cardiopulmonary bypass during the neonatal period could impact the systemic inflammatory response in the immediate postoperative period that manifests as cardiac depression and multi-organ dysfunction. This study aimed to determine the association of maternal obesity and excessive weight gain during pregnancy with the immediate postoperative morbidity of neonatal patients undergoing cardiopulmonary bypass...
December 14, 2017: Cardiology in the Young
https://www.readbyqxmd.com/read/29238916/impact-of-bariatric-surgical-intervention-on-peripheral-blood-neutrophil-pbn-function-in-obesity
#9
Helen M Roberts, Melissa M Grant, Naomi Hubber, Paul Super, Rishi Singhal, Iain L C Chapple
AIM: The aim of this study was to investigate the impact of weight loss following gastric band surgery on multiple measures of peripheral blood neutrophil (PBN) function. MATERIAL AND METHODS: Twenty-three obese patients undergoing gastric band surgery were recruited to a longitudinal intervention study, alongside non-obese, healthy gender- and age-matched controls. Eighteen pairs of patients and controls completed all stages of the study. PBNs were isolated by density centrifugation and a comprehensive analysis of PBN function was undertaken at various stages of the patients' bariatric surgical care pathway...
December 14, 2017: Obesity Surgery
https://www.readbyqxmd.com/read/29238655/duodenal-jejunal-bypass-surgery-reverses-diabetic-phenotype-and-reduces-obesity-in-db-db-mice
#10
Yongjun Liang, Yueqian Wang, Zhengdong Qiao, Ting Cao, Ying Feng, Lin Zhang, Peng Zhang
Type 2 diabetes mellitus (T2DM), a complex metabolic disorder typically accompanying weight gain, is associated with progressive β-cell failure and insulin resistance. Bariatric surgery ameliorates glucose tolerance and provides a near-perfect treatment. Duodenal-jejunal bypass (DJB) is an experimental procedure and has been studied in several rat models, but its influence in db/db mice, a transgenic model of T2DM, remains unclear. To investigate the effectiveness of DJB in db/db mice, we performed the surgery and evaluated metabolism improvement...
2017: Current Chemical Genomics and Translational Medicine
https://www.readbyqxmd.com/read/29238600/morbidity-and-health-related-quality-of-life-of-patients-accessing-laparoscopic-sleeve-gastrectomy-a-single-centre-cross-sectional-study-in-one-province-of-canada
#11
Laurie K Twells, Shannon Driscoll, Deborah M Gregory, Kendra Lester, John M Fardy, Dave Pace
Background: In Canada, severe obesity (BMI ≥ 35 kg/m2) affects 5% or 1.2 million adults. Bariatric surgery is the only effective treatment for severe obesity, but the demand for publicly funded procedures is high and capacity limited. Little is known in Canada about the types of patients undergoing these procedures, especially laparoscopic sleeve gastrectomy (LSG). The study objective is to examine the socio-demographic profile, morbidity and HRQoL of patients accessing LSG in one Canadian province...
2017: BMC Obesity
https://www.readbyqxmd.com/read/29237205/-how-does-diabetes-mellitus-influence-early-postoperative-results-and-survival-in-rectal-cancer
#12
Björn Gebauer, Frank Meyer, Henry Ptok, Ralf Steinert, Ronny Otto, Hans Lippert, Ingo Gastinger
Introduction Aim of this study was to investigate the influence of diabetes mellitus (DM) onto the early postoperative and long-term oncosurgical outcome after surgery for rectal cancer using data prospectively obtained in a representative number of patients. Methods Data (using a registration form of 68 items) from the ongoing multicenter observational study "rectal cancer (primary tumor) - elective surgery" on Quality Assurance was used including years 2008 to 2011. A voluntary and frequent follow-up was done to gain long-term data...
December 13, 2017: Deutsche Medizinische Wochenschrift
https://www.readbyqxmd.com/read/29237161/effects-of-intentional-weight-loss-on-markers-of-oxidative-stress-dna-repair-and-telomere-length-a-systematic-review
#13
Caroline Himbert, Henry Thompson, Cornelia M Ulrich
BACKGROUND: Altered levels of markers of oxidative stress, DNA repair, and telomere integrity have been detected in obese individuals and may underlie the pathogenesis of obesity-related diseases. However, whether or not such effects are reversed by intentional weight loss has not been systematically reviewed. METHODS: A literature search in PubMed/Medline identified 2,388 articles of which 21 studies (randomized controlled trial (RCT) (n = 10) and non-randomized intervention studies (n = 11)) were classified as testing the effects of intentional weight loss on i) oxidative stress (n = 15), ii) DNA repair (n = 2), and iii) telomere length (n = 4)...
December 14, 2017: Obesity Facts
https://www.readbyqxmd.com/read/29237132/anastomotic-stricture-rates-following-roux-en-y-gastric-bypass-for-morbid-obesity-a-comparison-between-linear-and-circular-stapled-anastomosis
#14
Harbi Khalayleh, Guy Pines, Ashraf Imam, Shimon Sapojnikov, Victor Buyeviz, Eli Mavor
BACKGROUND: Laparoscopic Roux-en-Y gastric bypass (LRYGB) is an effective procedure in the management of morbid obesity with variations in outcome, which are technique dependent. Anastomotic stricture remains an important complication. The aim of this study was to assess the long-term outcome of patients undergoing either a linear-stapled anastomosis (LSA) or circular-stapled anastomosis (CSA) with an emphasis on postoperative stricture formation and excess body weight loss (EBWL). METHODS: Medical records of all patients who underwent bariatric surgery between 2008 and 2013 at a single bariatric surgical center were reviewed...
December 13, 2017: Journal of Laparoendoscopic & Advanced Surgical Techniques. Part A
https://www.readbyqxmd.com/read/29236751/lysophosphatidic-acid-receptor-mrna-levels-in-heart-and-white-adipose-tissue-are-associated-with-obesity-in-mice-and-humans
#15
Amy Brown, Intekhab Hossain, Lester J Perez, Carine Nzirorera, Kathleen Tozer, Kenneth D'Souza, Purvi C Trivedi, Christie Aguiar, Alexandra M Yip, Jennifer Shea, Keith R Brunt, Jean-Francois Legare, Ansar Hassan, Thomas Pulinilkunnil, Petra C Kienesberger
BACKGROUND: Lysophosphatidic acid (LPA) receptor signaling has been implicated in cardiovascular and obesity-related metabolic disease. However, the distribution and regulation of LPA receptors in the myocardium and adipose tissue remain unclear. OBJECTIVES: This study aimed to characterize the mRNA expression of LPA receptors (LPA1-6) in the murine and human myocardium and adipose tissue, and its regulation in response to obesity. METHODS: LPA receptor mRNA levels were determined by qPCR in i) heart ventricles, isolated cardiomyocytes, and perigonadal adipose tissue from chow or high fat-high sucrose (HFHS)-fed male C57BL/6 mice, ii) 3T3-L1 adipocytes and HL-1 cardiomyocytes under conditions mimicking gluco/lipotoxicity, and iii) human atrial and subcutaneous adipose tissue from non-obese, pre-obese, and obese cardiac surgery patients...
2017: PloS One
https://www.readbyqxmd.com/read/29236274/outcomes-of-adenotonsillectomy-in-severe-pediatric-obstructive-sleep-apnea
#16
Karim El-Kersh, Rodrigo Cavallazzi, Egambaram Senthilvel
We conducted a retrospective chart review to examine the efficacy of adenotonsillectomy for the treatment of severe obstructive sleep apnea (OSA) in children. Our study population was made up of 85 patients-58 boys and 27 girls, aged 1 to 17 years (mean: 6.9 ± 4.4)-with severe OSA who had undergone adenotonsillectomy and pre- and postoperative attended polysomnography (PSG) over a 4-year period. Severe OSA was defined as an apnea-hypopnea index (AHI) of >10 events per hour of sleep. Patients who had an underlying genetic or craniofacial anomaly were excluded...
December 2017: Ear, Nose, & Throat Journal
https://www.readbyqxmd.com/read/29236131/trends-in-incidence-and-long-term-outcomes-of-myelomeningocele-in-british-columbia
#17
Taylor North, Alexander Cheong, Paul Steinbok, Julia Ae Radic
PURPOSE: Myelomeningocele is typically a disabling condition that results in neurologic, orthopedic, and urologic morbidity. The aim of this study was to examine the trends over time in both incidence and outcomes of myelomeningocele (MMC) in British Columbia (BC). METHODS: A retrospective chart review was performed of all children with MMC followed in the British Columbia Children's Hospital (BCCH) Spinal Cord Clinic between 1971 and 2016. The incidence of new MMC cases and the long-term outcomes of MMC were compared between two 10-year cohorts...
December 13, 2017: Child's Nervous System: ChNS: Official Journal of the International Society for Pediatric Neurosurgery
https://www.readbyqxmd.com/read/29235133/operating-on-the-self-transforming-agency-through-obesity-surgery-and-treatment
#18
Else Vogel
In this article, I describe the processes through which patients diagnosed with 'morbid obesity' become active subjects through undergoing obesity surgery and an empowerment lifestyle programme in a Dutch obesity clinic. Following work in actor-network theory and material semiotics that complicates the distinction between active and passive subjects, I trace how agency is configured and re-distributed throughout the treatment trajectory. In the clinic's elaborate care assemblage - consisting of dieticians, exercise coaches and psychologists - the person is not only actively involved in his/her own change, the subject of intervention is the self as 'actor': his/her material constitution, inclinations and feelings...
December 12, 2017: Sociology of Health & Illness
https://www.readbyqxmd.com/read/29235126/relationships-of-serum-25-hydroxyvitamin-d-ionized-calcium-and-parathyroid-hormone-after-obesity-surgery
#19
Stephen Hewitt, Erlend Tuseth Aasheim, Torgeir Thorson Søvik, Jørgen Jahnsen, Jon Kristinsson, Erik Fink Eriksen, Tom Mala
OBJECTIVE: The high prevalence of secondary hyperparathyroidism (SHPT) after obesity surgery is a concern for long-term bone health. Limited knowledge exists about optimal vitamin D and suppression of parathyroid hormone (PTH) after these procedures. The aim of this study was to investigate the prevalence of SHPT and its relation to vitamin D status. DESIGN: A cross-sectional study at Oslo University Hospital, Norway. PATIENTS: 502 consecutive patients, age 22-64 years, attending 2-year follow-up after Roux-en-Y gastric bypass...
December 13, 2017: Clinical Endocrinology
https://www.readbyqxmd.com/read/29235014/increased-bile-acid-signals-after-duodenal-jejunal-bypass-improve-non-alcoholic-steatohepatitis-nash-in-a-rodent-model-of-diet-induced-nash
#20
Takahiro Tsuchiya, Takeshi Naitoh, Munenori Nagao, Naoki Tanaka, Kazuhiro Watanabe, Hirofumi Imoto, Tomohiro Miyachi, Fuyuhiko Motoi, Michiaki Unno
BACKGROUND: The increasing incidence of non-alcoholic steatohepatitis (NASH) has resulted in it becoming a common cause of liver-related mortality; however, no efficient treatment has been established. It has been reported that bariatric surgery improves metabolic comorbidities, such as diabetes mellitus and NASH. Although the mechanism is unclear, it is thought that the changes in bile acid (BA) signaling via its nuclear receptor, farnesoid X receptor (FXR), produce various metabolic effects...
December 12, 2017: Obesity Surgery
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