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JOURNAL ARTICLE
Laura Malkus, Stefanie Bertram, Charlotte von Horn, Thomas Minor
Increasing shortage of donor organs leads to the acceptance of less than optimal grafts for transplantation, up to and including organs donated after circulatory standstill of the donor. Therefore, protective strategies and pharmacological interventions destined to reduce ischemia induced tissue injury are considered a worthwhile focus of research. The present study evaluates the potential of a multidrug pharmacological approach as single flush at the end of static preservation to protect the liver from reperfusion injury...
May 9, 2024: Cryobiology
#2
REVIEW
Syed Hussain Abbas, Carlo Domenico Lorenzo Ceresa, Joerg-Matthias Pollok
Liver transplantation (LT) is the only definitive treatment for end-stage liver disease, yet the UK has seen a 400% increase in liver disease-related deaths since 1970, constrained further by a critical shortage of donor organs. This shortfall has necessitated the use of extended criteria donor organs, including those with evidence of steatosis. The impact of hepatic steatosis (HS) on graft viability remains a concern, particularly for donor livers with moderate to severe steatosis which are highly sensitive to the process of ischaemia-reperfusion injury (IRI) and static cold storage (SCS) leading to poor post-transplantation outcomes...
April 24, 2024: International Journal of Molecular Sciences
#3
JOURNAL ARTICLE
Mengting Zhan, Deng Liu, Lei Yao, Weizhi Wang, Ruixin Zhang, Yaru Xu, Zhen Wang, Qi Yan, Qi Fang, Jian Du, Lijian Chen
BACKGROUND: Hepatic ischemia/reperfusion (I/R) injury is a major cause of complications in clinical liver surgery. AXL receptor tyrosine kinase (AXL) is a member of the TAM receptor tyrosine kinase family (TYRO3, AXL, and MERTK). Our previous study has shown that AXL expression was markedly upregulated in liver transplantation patients. However, the underlying mechanism of AXL in hepatic I/R injury remains unclear. METHODS: A mouse liver warm I/R model and a primary hepatocyte hypoxia/reoxygenation model were established to investigate the role of AXL activation and ferroptosis in hepatic I/R injury by pretreating with recombinant mouse growth arrest-specific protein 6 (AXL activator) or R428 (AXL inhibitor)...
May 10, 2024: Transplantation
#4
REVIEW
Si-Qi Yang, Xi Zhao, Jing Zhang, Dong-Ying Liao, Yu-Han Wang, Yao-Guang Wang
Ferroptosis is a novel form of programmed cell death that is iron-dependent and distinct from autophagy, apoptosis, and necroptosis. It is primarily characterized by a decrease in glutathione peroxidase 4 (GPX4) activity, or by the accumulation of lipid peroxidation and reactive oxygen species (ROS). Renal fibrosis is a common pathological change in the progression of various primary and secondary renal diseases to end-stage renal disease and poses a serious threat to human health with high morbidity and mortality...
May 9, 2024: Journal of Drug Targeting
#5
JOURNAL ARTICLE
Charlotte Vm Brown, Gilda Pino-Chavez, Aeliya Zaidi, Irina Grigorieva, Emma Woods, Robert Steadman, Rafael Chavez, Soma Meran, Usman Khalid
OBJECTIVES: Acute Kidney Injury (AKI) and Chronic Kidney Disease (CKD) are increasingly recognised as one disease continuum, rather than distinct entities, and are associated with a huge burden to healthcare services. The leading cause of AKI worldwide is Ischaemia Reperfusion Injury (IRI), most commonly seen in clinical settings of sepsis-driven hypotension. Ischaemic Preconditioning (IPC) is a strategy aimed at reducing the deleterious effects of IRI. The objectives of this study were to demonstrate an efficacious in vivo model of Kidney IRI, and the protective influence of IPC in attenuating AKI and development of renal fibrosis...
2024: International Journal of Clinical and Experimental Pathology
#6
JOURNAL ARTICLE
Yaru Chen, Jin Yan, Kai Wang, Zhenghua Zhu
BACKGROUND: Local ischemic preconditioning (LIPC) has been proven to be a protective strategy against hepatic ischemia-reperfusion injury (HIRI) during hepatectomy. Growing evidence suggests remote ischemic preconditioning (RIPC) has the potential to reduce liver injury in hepatectomy. Few studies have directly compared the protective effects of these two mechanical preconditioning strategies. Therefore, we performed a network meta-analysis to compare the efficacy of LIPC and RIPC for hepatic injury during liver resection...
2024: Translational Gastroenterology and Hepatology
#7
JOURNAL ARTICLE
Kang He, Xiaoli Qin, Mei Li, Longrong Bian, Honghua Yue, Weitao Liang, Zhong Wu
OBJECTIVE: Cerebral malperfusion (CM) is a common comorbidity in acute type A aortic dissection (ATAAD), which is associated with high mortality and poor neurological prognosis. This meta-analysis investigated the surgical strategy of ATAAD patients with CM, aiming to compare the difference in therapeutic effectiveness between the central repair-first and the early reperfusion-first according to clinical outcomes. METHODS: The meta-analysis and systematic review was conducted based on studies sourced from the PubMed, Embase, and Cochrane literature database, in which cases of ATAAD with CM underwent surgical repair were included...
May 7, 2024: BMC Cardiovascular Disorders
#8
JOURNAL ARTICLE
Lan Zhao, Yanan Li, Wei Wang, Xue Qi, Su Wang, Wenqin Song, Ting Li, Wenwei Gao
Ischemic stroke presents a global health challenge, necessitating an in-depth comprehension of its pathophysiology and therapeutic strategies. While reperfusion therapy salvages brain tissue, it also triggers detrimental cerebral ischemia-reperfusion injury (CIRI). In our investigation, we observed the activation of nuclear receptor coactivator 4 (NCOA4)-mediated ferritinophagy in an oxygen-glucose deprivation/reoxygenation (OGD/R) model using HT22 cells (P < 0.05). This activation contributed to oxidative stress (P < 0...
May 7, 2024: Neurochemical Research
#9
REVIEW
Enrique Balderas, Sandra Hj Lee, Neeraj K Rai, David M Mollinedo, Hannah E Duron, Dipayan Chaudhuri
Oxidative phosphorylation is regulated by mitochondrial calcium (Ca2+ ) in health and disease. In physiological states, Ca2+ enters via the mitochondrial Ca2+ uniporter and rapidly enhances NADH and ATP production. However, maintaining Ca2+ homeostasis is critical: insufficient Ca2+ impairs stress adaptation, while Ca2+ overload can trigger cell death. In this review, we delve into recent insights further defining the relationship between mitochondrial Ca2+ dynamics and oxidative phosphorylation. Our focus is on how such regulation affects cardiac function in health and disease, including heart failure, ischemia-reperfusion, arrhythmias, catecholaminergic polymorphic ventricular tachycardia, mitochondrial cardiomyopathies, Barth syndrome, and Friedreich's ataxia...
May 7, 2024: Physiology
#10
REVIEW
Simone Fezzi, Daixin Ding, Felix Mahfoud, Jiayue Huang, Alexandra J Lansky, Shengxian Tu, William Wijns
This Perspective article is a form of 'pastiche', inspired by the 1993 review by Lincoff and Topol entitled 'Illusion of reperfusion', and explores how their concept continues to apply to percutaneous revascularization in patients with coronary artery disease and ischaemia. Just as Lincoff and Topol argued that reperfusion of acute myocardial infarction was facing unresolved obstacles that hampered clinical success in 1993, we propose that challenging issues are similarly jeopardizing the potential benefits of stent-based angioplasty today...
May 7, 2024: Nature Reviews. Cardiology
#11
JOURNAL ARTICLE
(no author information available yet)
Chronic thromboembolic pulmonary hypertension (CTEPH) is classified as group IV pulmonary hypertension, characterized by thrombotic occlusion of the pulmonary arteries leading to vascular stenosis or obstruction, progressive increase in pulmonary vascular resistance and pulmonary arterial pressure, and eventual right heart failure. Unlike other types of pulmonary hypertension, the prognosis of CTEPH can be significantly improved by surgery, vascular intervention, and/or targeted drug therapy. Pulmonary endarterectomy (PEA) is the preferred treatment of choice for CTEPH...
May 12, 2024: Chinese Journal of Tuberculosis and Respiratory Diseases
#12
REVIEW
Qiangqiang Jiao, Li Xiang, Yuping Chen
As a vital energy source for cellular metabolism and tissue survival, the mitochondrion can undergo morphological or positional change and even shuttle between cells in response to various stimuli and energy demands. Multiple human diseases are originated from mitochondrial dysfunction, but the curative succusses by traditional treatments are limited. Mitochondrial transplantation therapy (MTT) is an innovative therapeutic approach that is to deliver the healthy mitochondria either derived from normal cells or reassembled through synthetic biology into the cells and tissues suffering from mitochondrial damages and finally replace their defective mitochondria and restore their function...
May 2, 2024: International Journal of Pharmaceutics
#13
JOURNAL ARTICLE
Xiaoge Li, Chunying Shi, Runxue Zhou, Xinhui Chen, Qingling Xu, Chunyige Zhao, Mengyao Ma, Xiang Ao, Ying Liu
Acute kidney injury (AKI) is a life-threatening disease primarily caused by renal ischemia-reperfusion (I/R) injury, which can result in renal failure. Currently, growth factor therapy is considered a promising and effective approach for AKI treatment. Basic fibroblast growth factor (bFGF), an angiogenic factor with potent activity, efficiently stimulates angiogenesis and facilitates regeneration of renal tissue. However, the unrestricted diffusion of bFGF restricts its clinical application in AKI treatment...
May 3, 2024: Journal of Biomedical Materials Research. Part A
#14
JOURNAL ARTICLE
Rui Wen, Miaoran Wang, Wei Bian, Haoyue Zhu, Ying Xiao, Jing Zeng, Qian He, Yu Wang, Xiaoqing Liu, Yangdi Shi, Zhe Hong, Bing Xu
BACKGROUND: Timely intravenous thrombolysis (IVT) is crucial for improving outcomes in acute ischemic stroke (AIS) patients. This study evaluates the effectiveness of the Acute Stroke Care Map (ASCaM) initiative in Shenyang, aimed at reducing door-to-needle times (DNT) and thus improving the timeliness of care for AIS patients. METHODS: An retrospective cohort study was conducted from April 2019 to December 2021 in 30 hospitals participating in the ASCaM initiative in Shenyang...
2024: Frontiers in Neurology
#15
JOURNAL ARTICLE
Hyunsu Jeong, Hyunseok Lim, Chiho Yoon, Jongjun Won, Grace Yoojin Lee, Ezequiel de la Rosa, Jan S Kirschke, Bumjoon Kim, Namkug Kim, Chulhong Kim
Ischemic stroke segmentation at an acute stage is vital in assessing the severity of patients' impairment and guiding therapeutic decision-making for reperfusion. Although many deep learning studies have shown attractive performance in medical segmentation, it is difficult to use these models trained on public data with private hospitals' datasets. Here, we demonstrate an ensemble model that employs two different multimodal approaches for generalization, a more effective way to perform on external datasets...
May 1, 2024: J Imaging Inform Med
#16
REVIEW
Frazer I Heinis, Shaheed Merani, Nicholas W Markin, Kim F Duncan, Michael J Moulton, Lance Fristoe, William E Thorell, Raechel A Sherrick, Tami R Wells, Matthew T Andrews, Marian Urban
Use of animal models in preclinical transplant research is essential to the optimization of human allografts for clinical transplantation. Animal models of organ donation and preservation help to advance and improve technical elements of solid organ recovery and facilitate research of ischemia-reperfusion injury, organ preservation strategies, and future donor-based interventions. Important considerations include cost, public opinion regarding the conduct of animal research, translational value, and relevance of the animal model for clinical practice...
April 30, 2024: Animal Models and Experimental Medicine
#17
REVIEW
K P Divya, Navjot Kanwar, P V Anuranjana, Gautam Kumar, Fathima Beegum, Krupa Thankam George, Nitesh Kumar, K Nandakumar, Abhinav Kanwal
Cardiovascular diseases (CVDs) can be described as a global health emergency imploring possible prevention strategies. Although the pathogenesis of CVDs has been extensively studied, the role of mitochondrial dysfunction in CVD development has yet to be investigated. Diabetic cardiomyopathy, ischemic-reperfusion injury, and heart failure are some of the CVDs resulting from mitochondrial dysfunction Recent evidence from the research states that any dysfunction of mitochondria has an impact on metabolic alteration, eventually causes the death of a healthy cell and therefore, progressively directing to the predisposition of disease...
April 30, 2024: Cardiovascular Toxicology
#18
JOURNAL ARTICLE
Qingsheng Li, Lingfei Yang, Kaixin Wang, Ziyi Chen, Huimin Liu, Xuan Yang, Yudi Xu, Yufei Chen, Zhe Gong, Yanjie Jia
In the context of stroke and revascularization therapy, brain ischemia-reperfusion injury is a significant challenge that leads to oxidative stress and inflammation. Central to the cell's intrinsic immunity is the cGAS-STING pathway, which is typically activated by unusual DNA structures. The involvement of oxidized mitochondrial DNA (ox-mtDNA)-an oxidative stress byproduct-in this type of neurological damage has not been fully explored. This study is among the first to examine the effect of ox-mtDNA on the innate immunity of neurons following ischemia-reperfusion injury...
April 29, 2024: Neurotherapeutics: the Journal of the American Society for Experimental NeuroTherapeutics
#19
JOURNAL ARTICLE
Tanya Smith, Aeliya Zaidi, Charlotte Victoria Maynard Brown, Gilda Pino-Chavez, Timothy Bowen, Soma Meran, Donald Fraser, Rafael Chavez, Usman Khalid
BACKGROUND/AIM: Acute and chronic kidney diseases are a major contributor to morbidity and mortality worldwide, with no specific treatments currently available for these. To enable understanding the pathophysiology of and testing novel treatments for acute and chronic kidney disease, a suitable in vivo model of kidney disease is essential. In this article, we describe two reliable rodent models (rats and mice) of efficacious kidney injury displaying acute to chronic kidney injury progression, which is also reversible through novel therapeutic strategies such as ischemic preconditioning (IPC)...
2024: In Vivo
#20
JOURNAL ARTICLE
Răzvan Alexandru Radu, Vincent Costalat, Michele Romoli, Basel Musmar, James E Siegler, Sherief Ghozy, Jane Khalife, Hamza Salim, Hamza Shaikh, Nimer Adeeb, Hugo H Cuellar-Saenz, Ajith J Thomas, Ramanathan Kadirvel, Mohamad Abdalkader, Piers Klein, Thanh N Nguyen, Jeremy J Heit, Robert W Regenhardt, Joshua D Bernstock, Aman B Patel, James D Rabinov, Christopher J Stapleton, Nicole M Cancelliere, Thomas R Marotta, Vitor Mendes Pereira, Kareem El Naamani, Abdelaziz Amllay, Stavropoula I Tjoumakaris, Pascal Jabbour, Lukas Meyer, Jens Fiehler, Tobias D Faizy, Helena Guerreiro, Anne Dusart, Flavio Bellante, Géraud Forestier, Aymeric Rouchaud, Charbel Mounayer, Anna Luisa Kühn, Ajit S Puri, Christian Dyzmann, Peter T Kan, Marco Colasurdo, Gaultier Marnat, Jérôme Berge, Xavier Barreau, Igor Sibon, Simona Nedelcu, Nils Henninger, Takahiro Ota, Shogo Dofuku, Leonard L L Yeo, Benjamin Yq Tan, Anil Gopinathan, Juan Carlos Martinez-Gutierrez, Sergio Salazar-Marioni, Sunil Sheth, Leonardo Renieri, Carolina Capirossi, Ashkan Mowla, Lina M Chervak, Achala Vagal, Priyank Khandelwal, Arundhati Biswas, Frédéric Clarençon, Mahmoud Elhorany, Kevin Premat, Iacopo Valente, Alessandro Pedicelli, Andrea M Alexandre, João Pedro Filipe, Ricardo Varela, Miguel Quintero-Consuegra, Nestor R Gonzalez, Markus A Ymd, Jessica Jesser, Charlotte Weyland, Adrien Ter Schiphorst, Vivek Yedavalli, Pablo Harker, Yasmin Aziz, Benjamin Gory, Christian Paul Stracke, Constantin Hecker, Monika Killer-Oberpfalzer, Christoph J Griessenauer, Cheng-Yang Hsieh, David S Liebeskind, Illario Tancredi, Robert Fahed, Boris Lubicz, Muhammed Amir Essibayi, Amanda Baker, David Altschul, Luca Scarcia, Erwah Kalsoum, Adam A Dmytriw, Adrien Guenego
BACKGROUND: Optimal anesthetic strategy for the endovascular treatment of stroke is still under debate. Despite scarce data concerning anesthetic management for medium and distal vessel occlusions (MeVOs) some centers empirically support a general anesthesia (GA) strategy in these patients. METHODS: We conducted an international retrospective study of MeVO cases. A propensity score matching algorithm was used to mitigate potential differences across patients undergoing GA and conscious sedation (CS)...
April 30, 2024: Clinical Neuroradiology
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