Lucas Opazo-Ríos, Antonio Tejera-Muñoz, Manuel Soto Catalan, Vanessa Marchant, Carolina Lavoz, Sebastián Mas Fontao, Juan Antonio Moreno, Marta Fierro Fernandez, Ricardo Ramos, Beatriz Suarez-Alvarez, Carlos López-Larrea, Marta Ruiz-Ortega, Jesús Egido, Raúl R Rodrigues-Díez
Diabetic nephropathy (DN) is the main leading cause of chronic kidney disease worldwide. Although remarkable therapeutic advances have been made during the last few years, there still exists a high residual risk of disease progression to end-stage renal failure. To further understand the pathogenesis of tissue injury in this disease, by means of the Next-Generation Sequencing, we have studied the microRNA (miRNA) differential expression pattern in kidneys of Black and Tan Brachyury (BTBR) ob/ob (leptin deficiency mutation) mouse...
2022: Frontiers in Pharmacology