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perihilar cholangiocarcinoma

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https://www.readbyqxmd.com/read/28229074/imaging-of-cholangiocarcinoma
#1
REVIEW
Susann-Cathrin Olthof, Ahmed Othman, Stephan Clasen, Christina Schraml, Konstantin Nikolaou, Malte Bongers
Cholangiocarcinoma (CC) is the second most common primary hepatobiliary tumour, and it is increasing in incidence. Imaging characteristics, behaviour, and therapeutic strategies in CC differ significantly, depending on the morphology and location of the tumour. In cross-sectional imaging, CCs can be classified according to the growth pattern (mass-forming, periductal infiltrating, intraductal) and the location (intrahepatic, perihilar, extrahepatic/distal). The prognosis of CC is unfavourable and surgical resection is the only curative treatment option; thus, early diagnosis (also in recurrent disease) and accurate staging including the evaluation of lymph node involvement and vascular infiltration is crucial...
December 2016: Visceral Medicine
https://www.readbyqxmd.com/read/28209950/-clinico-pathological-factors-and-prognosis-scale-for-portal-cholangiocarcinoma
#2
Yu O Zharikov, Yu A Kovalenko, A A Olifir, D V Kalinin, A V Czhao
INTRODUCTION: The objective of this study was to derive a prognostic scale to predict overall survival (OS) after a curative resection of perihilar cholangiocarcinoma (PHC). MATERIAL AND METHODS: The data of 55 patients with portal cholangiocarcinoma were analysed. Patients were treated at the A.V. Vishnevsky Institute of Surgery from 2011 to 2015. Surgical treatment after biliary decompression was performed in 37 (67.3%) patients. In the long-term period we observed 36 (97...
2017: Khirurgiia
https://www.readbyqxmd.com/read/28202062/isolated-igg4-related-sclerosing-cholangitis-misdiagnosed-as-malignancy-in-an-area-with-endemic-cholangiocarcinoma-a-case-report
#3
Narongsak Rungsakulkij, Pattana Sornmayura, Penampai Tannaphai
BACKGROUND: The most common cause of perihilar obstruction is cholangiocarcinoma, especially in Thailand. Benign perihilar stricture represents less than 20% of cases. IgG4-related disease and IgG4-related sclerosing cholangitis, however, have been receiving increased recognition. Isolated IgG4-related sclerosing cholangitis is less common. The preoperative diagnosis of IgG4-related sclerosing cholangitis without pancreatic involvement is very difficult because the clinical presentation and preoperative evaluation are extremely difficult to distinguish from perihilar cholangiocarcinoma...
February 15, 2017: BMC Surgery
https://www.readbyqxmd.com/read/28187867/clinicopathologic-study-on-metachronous-double-cholangiocarcinomas-of-perihilar-and-subsequent-distal-bile-duct-origin
#4
Kentaro Shinohara, Yoshie Shimoyama, Tomoki Ebata, Yukihiro Yokoyama, Takashi Mizuno, Masato Nakaguro, Masato Nagino
BACKGROUND: Despite an increasing number of long-term survivors after the resection of perihilar cholangiocarcinoma, metachronous carcinoma in the remnant distal bile duct has not been well documented because of its rarity. The aim of this study was to clarify the feasibility of operative resection and the pathologic features for metachronous double cholangiocarcinomas. METHODS: Between 2003 and 2013, 6 patients underwent resections for both a primary perihilar cholangiocarcinoma and a metachronous distal cholangiocarcinoma...
February 7, 2017: Surgery
https://www.readbyqxmd.com/read/28133229/-lymph-node-recurrence-of-small-cell-carcinoma-of-the-extrahepatic-bile-ducts-effectively-treated-with-cisplatin-plus-irinotecan-chemotherapy-report-of-a-case
#5
Tomohiro Katada, Jun Sakata, Takuya Ando, Daiki Soma, Kizuki Yuza, Koji Toge, Yuki Hirose, Hirosuke Ishikawa, Kohei Miura, Taku Ohashi, Kazuyasu Takizawa, Kabuto Takano, Takashi Kobayashi, Hitoshi Kameyama, Toshifumi Wakai
A 78-year-old man with jaundice was diagnosed with perihilar cholangiocarcinoma(Bismuth type I ). After endoscopic biliary drainage for jaundice, a subtotal stomach-preserving pancreaticoduodenectomy was performed. Histologic examination and immunohistochemical staining with chromogranin A, synaptophysin, and CD56 resulted in a diagnosis of small cell carcinoma. Of the 18 dissected lymph nodes, 8 nodes contained a metastatic tumor. Left supraclavicular and paraaortic lymph node metastases were detected by computed tomography 5 months after the resection...
November 2016: Gan to Kagaku Ryoho. Cancer & Chemotherapy
https://www.readbyqxmd.com/read/28105527/pulmonary-metastasis-after-resection-of-cholangiocarcinoma-incidence-resectability-and-survival
#6
Mihoko Yamada, Tomoki Ebata, Yukihiro Yokoyama, Tsuyoshi Igami, Gen Sugawara, Takashi Mizuno, Junpei Yamaguchi, Masato Nagino
BACKGROUND: There are few reports on pulmonary metastasis from cholangiocarcinoma; therefore, its incidence, resectability, and survival are unclear. METHODS: Patients who underwent surgical resection for cholangiocarcinoma, including intrahepatic, perihilar, and distal cholangiocarcinoma were retrospectively reviewed, and this study focused on patients with pulmonary metastasis. RESULTS: Between January 2003 and December 2014, 681 patients underwent surgical resection for cholangiocarcinoma...
January 19, 2017: World Journal of Surgery
https://www.readbyqxmd.com/read/28097412/acute-pancreatitis-after-percutaneous-biliary-drainage-an-obstacle-in-liver-surgery-for-proximal-biliary-cancer
#7
Nadia Russolillo, Andrea Massobrio, Serena Langella, Roberto Lo Tesoriere, Paolo Carbonatto, Alessandro Ferrero
BACKGROUND: Percutaneous transhepatic biliary drainage (PTBD) has a crucial role in treatment of proximal biliary cancer (PBC). We assessed the incidence, risk factors, and impact of acute pancreatitis (AP) post-PTBD. METHODS: Forty patients with PBC scheduled for PTBD from January 2005 to December 2015 were enrolled. Exclusion criteria were missing clinical data, PTBD performed in other institutions, and palliative PTBD. RESULT: The 40 patients comprised 8 (20%) with gallbladder cancer, 6 (15%) with intrahepatic cholangiocarcinoma, and 26 (65%) with perihilar cholangiocarcinoma...
January 17, 2017: World Journal of Surgery
https://www.readbyqxmd.com/read/28094162/intrahepatic-cholangiocarcinoma
#8
Masayuki Nakano, Shun-Ichi Ariizumi, Masakazu Yamamoto
Cholangiocarcinoma, also referred to as cholangiocellular carcinoma (particularly in Japan), develops along the biliary tract. The tumor may be intra- or extrahepatic and have different features with specific treatments based on the site of origin. Guidelines for diagnosis and management of cholangiorcarcinoma, such as those proposed by EASL (European Association for the Study of the Liver)(1) and the Mayo Clinic(2) classify the tumor into intrahepatic, perihilar, and distal cholangiocarcinoma. There are three main macroscopic patterns of growth of cholangiocarcinoma: mass-forming, periductal-infiltrating and intraductal...
January 5, 2017: Seminars in Diagnostic Pathology
https://www.readbyqxmd.com/read/28094085/what-is-the-most-accurate-lymph-node-staging-method-for-perihilar-cholangiocarcinoma-comparison-of-uicc-ajcc-pn-stage-number-of-metastatic-lymph-nodes-lymph-node-ratio-and-log-odds-of-metastatic-lymph-nodes
#9
S Conci, A Ruzzenente, M Sandri, F Bertuzzo, T Campagnaro, F Bagante, P Capelli, M D'Onofrio, M Piccino, A E Dorna, C Pedrazzani, C Iacono, A Guglielmi
BACKGROUND: We compared the prognostic performance of the International Union Against Cancer/American Joint Committee on Cancer (UICC/AJCC) 7th edition pN stage, number of metastatic LNs (MLNs), LN ratio (LNR), and log odds of MLNs (LODDS) in patients with perihilar cholangiocarcinoma (PCC) undergoing curative surgery in order to identify the best LN staging method. METHODS: Ninety-nine patients who underwent surgery with curative intent for PCC in a single tertiary hepatobiliary referral center were included in the study...
January 8, 2017: European Journal of Surgical Oncology
https://www.readbyqxmd.com/read/28089541/insulin-like-growth-factor-ii-mrna-binding-protein-3-imp3-is-a-marker-that-predict-presence-of-invasion-in-papillary-biliary-tumors
#10
Motoko Sasaki, Yasunori Sato
Biliary tumors showing intraductal papillary growth (Pap-BT) include intraductal papillary neoplasm of the bile duct (IPNB) and papillary cholangiocarcinoma (CC). A differential diagnosis between IPNB and papillary CC currently remains challenging. The aim of the present study is to identify histological features and immunohistochemical markers of malignant potential such as tumor invasion in Pap-BT. Subjects comprised 37 patients with Pap-BT (intrahepatic and perihilar (proximal), 27; 17 non-invasive and 10 invasive); distal 10, all invasive)...
January 13, 2017: Human Pathology
https://www.readbyqxmd.com/read/28051802/%C3%A2-intrahepatic-perihilar-and-distal-cholangiocarcinoma-management-and-outcomes
#11
David Waseem, Patel Tushar
:  Introduction and aims. Cholangiocarcinomas are a heterogeneous group of tumors that can be classified into three clinically distinct types of cancers, intrahepatic, perihilar and distal cholangiocarcinoma. The inconsistent use of nomenclature for these cancers has obscured a true knowledge of the epidemiology, natural history and response to therapy of these cancers. Our aims were to define demographic characteristics, management and outcomes of these three distinct cancer types. MATERIALS AND METHODS: A retrospective study of patients enrolled in an institutional cancer registry from 1992 to 2010...
January 2017: Annals of Hepatology
https://www.readbyqxmd.com/read/28012034/surgical-treatment-of-perihilar-cholangiocarcinoma-early-results-of-en-bloc-portal-vein-resection
#12
Víctor Molina, Jaime Sampson, Joana Ferrer, Alba Díaz, Juan Ramon Ayuso, Santiago Sánchez-Cabús, Josep Fuster, Juan Carlos García-Valdecasas
OBJECTIVE: The objective of this study was to analyse the safety, feasibility and survival outcomes of our treatment of perihilar cholangiocarcinoma (PHC) since the introduction of more aggressive approaches (en bloc, vascular and extended liver resections) in 2007. PATIENTS AND METHODS: From July 2007 to December 2014, 32 consecutive patients with PHC underwent surgery with curative intent. Surgery with resection and reconstruction of the portal vein bifurcation and right hepatic artery was performed if necessary for a complete removal of the tumour...
December 23, 2016: Langenbeck's Archives of Surgery
https://www.readbyqxmd.com/read/28008345/major-hepatectomy-using-the-glissonean-approach-in-cases-of-right-umbilical-portion
#13
Yusuke Ome, Kazuyuki Kawamoto, Tae Bum Park, Tadashi Ito
Right umbilical portion (RUP) is a rare congenital anomaly associated with anomalous ramifications of the hepatic vessels and biliary system. As such, major hepatectomy requires a careful approach. We describe the usefulness of the Glissonean approach in two patients with vessel anomalies, such as RUP. The first patient underwent a right anterior sectionectomy for intrahepatic cholangiocarcinoma. We encircled several Glissonean pedicles that entered the right anterior section along the right side of the RUP...
December 8, 2016: World Journal of Hepatology
https://www.readbyqxmd.com/read/27995089/current-status-on-cholangiocarcinoma-and-gallbladder-cancer
#14
REVIEW
Tomoki Ebata, Giorgio Ercolani, Domenico Alvaro, Dario Ribero, Luca Di Tommaso, Juan W Valle
BACKGROUND: Cholangiocarcinomas (CC) as well as gallbladder cancers are relatively rare and intractable diseases. Clinical, pathological, and epidemiological studies on these tumors have been under investigation. The current status and/or topics on biliary tract cancers have been reported in the East West Association of Liver Tumor (EWALT), held in Milano, Italy in 2015. SUMMARY: All the authors, herein, specifcally reported the current status and leading-edge findings on biliary tract cancers as the following sequence: epidemiology of CC, surgical therapy for intrahepatic CC, surgical therapy for perihilar CC, surgical therapy for gallblad der cancer, chemotherapy for biliary tract cancers, and new histological features in CC...
November 2016: Liver Cancer
https://www.readbyqxmd.com/read/27984121/an-s100p-positive-biliary-epithelial-field-is-a-pre-invasive-intraepithelial-neoplasm-in-nodular-sclerosing-cholangiocarcinoma
#15
Yasuni Nakanuma, Tsuneyuki Uchida, Yasunori Sato, Katsuhiko Uesaka
Nodular sclerosing cholangiocarcinoma (NS-CCA) is a common CCA of the intrahepatic large, perihilar and distal bile ducts. Intraepithelial biliary neoplasms, such as the mucosal extension of carcinoma and pre-invasive neoplastic lesions (i.e. biliary intraepithelial neoplasia [BilIN]) reportedly occur in the bile ducts around CCA. In the present study, we collectively refer to these intraepithelial lesions as "intraepithelial neoplasms of the bile duct (IENBs)". We examined the IENBs in 57 surgically resected cases of NS-CCA...
October 28, 2016: Human Pathology
https://www.readbyqxmd.com/read/27940488/survival-of-surgery-for-recurrent-biliary-tract-cancer-a-single-center-experience-and-systematic-review-of-literature
#16
Yoshihiro Miyazaki, Takashi Kokudo, Katsumi Amikura, Yumiko Kageyama, Amane Takahashi, Nobuhiro Ohkohchi, Hirohiko Sakamoto
BACKGROUND: For recurrent biliary tract cancer, chemotherapy is the standard treatment. However, the efficacy of surgery is unknown. Here, the prognostic benefit of surgery for recurrent biliary tract cancer was investigated. METHODS: Data of 206 patients who underwent surgery for biliary tract cancer between 2005 and 2015 were retrospectively analyzed. Of these, 107 recurrent patients were divided into two groups, surgery (n = 14) and non-surgery (n = 93) groups...
December 8, 2016: Japanese Journal of Clinical Oncology
https://www.readbyqxmd.com/read/27928598/the-role-of-adjuvant-therapy-after-r0-resection-for-patients-with-intrahepatic-and-perihilar-cholangiocarcinomas
#17
Young Saing Kim, Sung Yong Oh, Se-Il Go, Jung-Hun Kang, Inkeun Park, Haa-Na Song, Jun Ho Ji, In Gyu Hwang, Joung-Soon Jang
PURPOSE: There is still debated regarding the optimal treatment strategy for cholangiocarcinoma (CC) after curative resection. The aim of this study was to analyze the role of adjuvant therapy in R0-resected intrahepatic and perihilar CCs. METHODS: We retrospectively reviewed the patients who underwent R0 resection for intrahepatic and perihilar CCs between January 2001 and December 2013 at six tertiary medical centers; adjuvant therapy consisted of chemotherapy (CT), chemoradiotherapy (CRT), or radiotherapy (RT)...
December 7, 2016: Cancer Chemotherapy and Pharmacology
https://www.readbyqxmd.com/read/27919984/clinical-significances-of-preoperative-classification-of-intrahepatic-cholangiocarcinoma-different-characteristics-of-perihilar-vs-peripheral-icc
#18
Yo-Ichi Yamashita, Huanlin Wang, Takeshi Kurihara, Eiji Tsujita, Akihiro Nishie, Katsunori Imai, Daisuke Hashimoto, Akira Chikamoto, Shinichi Aishima, Hideo Baba
BACKGROUND: The aim of this study was to evaluate the clinical significance of preoperative classification of intrahepatic cholangiocarcinoma (ICC) into perihilar and peripheral types using dynamic computed tomography (CT). PATIENTS AND METHODS: A retrospective cohort study was performed to analyze the differences in clinical characteristics between perihilar and peripheral ICC samples from patients between 1990-2014. RESULTS: A total of 87 patients were divided into three ICC subtypes; perihilar (n=34), peripheral (n=44), and unclassifiable ICC (n=9)...
2016: Anticancer Research
https://www.readbyqxmd.com/read/27896655/transhepatic-hilar-approach-for-perihilar-cholangiocarcinoma-significance-of-early-judgment-of-resectability-and-safe-vascular-reconstruction
#19
Naohisa Kuriyama, Shuji Isaji, Akihiro Tanemura, Yusuke Iizawa, Hiroyuki Kato, Yasuhiro Murata, Yoshinori Azumi, Masashi Kishiwada, Shugo Mizuno, Masanobu Usui, Hiroyuki Sakurai
In the most common surgical procedure for perihilar cholangiocarcinoma, the margin status of the proximal bile duct is determined at the final step. Our procedure, the transhepatic hilar approach, confirms a cancer-negative margin status of the proximal bile duct first. We first performed a partial hepatic parenchymal transection to expose the hilar plate, and then transected the proximal bile duct to confirm margin status. Then, divisions of the hepatic artery and portal vein of the future resected liver are performed, followed by the residual hepatic parenchymal transection...
November 28, 2016: Journal of Gastrointestinal Surgery: Official Journal of the Society for Surgery of the Alimentary Tract
https://www.readbyqxmd.com/read/27861766/role-of-staging-laparoscopy-in-the-stratification-of-patients-with-perihilar-cholangiocarcinoma
#20
N Bird, M Elmasry, R Jones, M Elniel, M Kelly, D Palmer, S Fenwick, G Poston, H Malik
BACKGROUND: Cholangiocarcinoma is a rare cancer with a poor prognosis. Radical surgical resection is the only option for curative treatment. Optimal determination of resectability is required so that patients can be stratified into operative or chemotherapeutic treatment cohorts in an accurate and time-efficient manner. Staging laparoscopy is utilized to determine the presence of radiologically occult disease that would preclude further surgical treatment. The aim of this study was to analyse the utility of staging laparoscopy in a contemporary cohort of patients with perihilar cholangiocarcinoma...
March 2017: British Journal of Surgery
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