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perihilar cholangiocarcinoma

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https://www.readbyqxmd.com/read/28721561/enbd-is-associated-with-decreased-tumor-dissemination-compared-to-ptbd-in-perihilar-cholangiocarcinoma
#1
Ryota Higuchi, Takehisa Yazawa, Shuichiro Uemura, Wataru Izumo, Rohan Jagat Chaudhary, Toru Furukawa, Masakazu Yamamoto
BACKGROUND: Little is known regarding the risk of tumor dissemination when percutaneous biliary drainage is used before surgical resection of perihilar cholangiocarcinoma (PHC). We aimed to compare the incidence of tumor dissemination after preoperative endoscopic nasobiliary drainage (ENBD) with that after percutaneous transhepatic biliary drainage (PTBD) for PHC. METHODS: Data from 208 consecutive patients who underwent PHC resection between 2000 and 2013 were retrospectively analyzed...
July 18, 2017: Journal of Gastrointestinal Surgery: Official Journal of the Society for Surgery of the Alimentary Tract
https://www.readbyqxmd.com/read/28717821/-perihilar-cholangiocarcinoma-bismuth-type%C3%A2-iv-resection-frequently-possible
#2
O Strobel, M W Büchler
No abstract text is available yet for this article.
July 17, 2017: Der Chirurg; Zeitschrift Für Alle Gebiete der Operativen Medizen
https://www.readbyqxmd.com/read/28693238/intranuclear-accumulation-of-galectin-3-is-an-independent-prognostic-factor-for-patients-with-distal-cholangiocarcinoma
#3
Tatsuo Shimura, Yasuhide Kofunato, Ryo Okada, Rei Yashima, Yoshihisa Koyama, Kenichiro Araki, Hiroyuki Kuwano, Seiichi Takenoshita
Galectin-3 has been reported to be associated with the prognosis of patients with various malignancies; however, it has not yet been investigated in patients with extrahepatic cholangiocarcinoma (EHCC). Expression of galectin-3 was retrospectively examined in 58 patients with EHCC: 21 with perihilar cholangiocarcinoma and 37 with distal cholangiocarcinoma (DCC). The Cox proportional hazard model was used to identify independent prognostic factors. Intranuclear accumulation of galectin-3 (gal-3-INA) was associated with poorer overall survival (OS) in all patients (P=0...
July 2017: Oncology Letters
https://www.readbyqxmd.com/read/28687509/postoperative-liver-failure-risk-score-identifying-patients-with-resectable-perihilar-cholangiocarcinoma-who-may-benefit-from-portal-vein-embolization
#4
Pim B Olthof, Jimme K Wiggers, Bas Groot Koerkamp, Robert J Coelen, Peter J Allen, Marc G Besselink, Olivier R Busch, Michael I D'Angelica, Ronald P DeMatteo, T Peter Kingham, Krijn P van Lienden, William R Jarnagin, Thomas M van Gulik
BACKGROUND: Major liver resection for perihilar cholangiocarcinoma (PHC) is associated with a 22-33% postoperative liver failure (LF) incidence. The aim of this study was analyze the predictive value of future liver remnant (FLR) volume for postoperative LF after resection for PHC and to develop a risk score in order to improve patient selection for portal vein embolization (PVE) STUDY DESIGN: A consecutive series of 217 patients underwent major liver resection for PHC between 1997 and 2014 at two Western centers; FLR volumes were calculated with CT volumetry and other variables included jaundice at presentation, immediate preoperative bilirubin, and preoperative cholangitis...
July 4, 2017: Journal of the American College of Surgeons
https://www.readbyqxmd.com/read/28687148/-99m-tc-mebrofenin-hepatobiliary-scintigraphy-predicts-liver-failure-following-major-liver-resection-for-perihilar-cholangiocarcinoma
#5
Pim B Olthof, Robert J S Coelen, Roelof J Bennink, Michal Heger, Meng F Lam, Marc G Besselink, Olivier R Busch, Krijn P van Lienden, Thomas M van Gulik
BACKGROUND: Posthepatectomy liver failure (PHLF) is a threatening complication after liver surgery, especially in perihilar cholangiocarcinoma (PHC). This study aimed to assess the value of preoperative assessment of liver function using (99m)Tc-mebrofenin hepatobiliary scintigraphy (HBS) to predict PHLF in comparison with liver volume in PHC patients. METHODS: All patients who underwent resection of suspected PHC in a single center between 2000 and 2015 were included in the analysis...
July 4, 2017: HPB: the Official Journal of the International Hepato Pancreato Biliary Association
https://www.readbyqxmd.com/read/28675366/curative-intent-surgery-for-perihilar-cholangiocarcinoma-with-and-without-portal-vein-resection-a-comparative-analysis-of-early-and-late-outcomes
#6
Traian Dumitraşcu, Cezar Stroescu, Vladislav Braşoveanu, Vlad Herlea, Mihnea Ionescu, Irinel Popescu
Introduction: The safety of portal vein resection (PVR) during surgery for perihilar cholangiocarcinoma (PHC) has been demonstrated in Asia, America, and Western Europe. However, no data about this topic are reported from Eastern Europe. The aim of the present study is to comparatively assess the early and long-term outcomes after resection for PHC with and without PVR. PATIENTS AND METHODS: The data of 21 patients with PVR were compared with those of 102 patients with a curative-intent surgery for PHC without PVR...
May 2017: Chirurgia
https://www.readbyqxmd.com/read/28675356/current-management-of-perihilar-cholangiocarcinoma-and-future-perspectives
#7
Heather L Lewis, Amir A Rahnemai-Azar, Mary Dillhoff, Carl R Schmidt, Timothy M Pawlik
Perihilar cholangiocarcinoma is the most common type of biliary tract cancer and is associated with a high mortality, usually due to late presentation. High-resolution cross-sectional imaging modalities are necessary for diagnosis and preoperative planning. Although surgical resection with negative margins offers the only hope for cure, only a small subset of patients are amenable for surgery at the time of diagnosis. Portal vein embolization and biliary tract decompression are important in some patients prior to surgical resection...
May 2017: Chirurgia
https://www.readbyqxmd.com/read/28668872/impact-and-prediction-of-lymph-node-involvement-in-patients-with-intrahepatic-cholangiocarcinoma-after-curative-resection
#8
Noboru Harada, Tomoharu Yoshizumi, Yo-Ichi Yamashita, Yuji Soejima, Toru Ikegami, Norifumi Harimoto, Shinji Itoh, Yoshihiko Maehara
BACKGROUND: The aim of this study was to identify the preoperative predictors of prognosis in patients with intrahepatic cholangiocarcinoma (ICC) undergoing resection. PATIENTS AND METHODS: We enrolled 90 patients with ICC who underwent surgical resection, including 59 in whom surgery was considered curative, and measured the overall survival (OS), recurrence-free survival (RFS), and other outcomes and potential prognostic factors. RESULTS: Multivariate Cox proportional hazards analysis showed that tumor in the resection margins (R>0) independently predicted long-term OS in the whole cohort...
July 2017: Anticancer Research
https://www.readbyqxmd.com/read/28645247/the-correlation-between-poor-prognosis-and-increased-yes-associated-protein-1-expression-in-keratin-19-expressing-hepatocellular-carcinomas-and-cholangiocarcinomas
#9
KyuHo Lee, Kyoung-Bun Lee, Hae Yoen Jung, Nam-Joon Yi, Kwang-Woong Lee, Kyung-Suk Suh, Ja-June Jang
BACKGROUND: The Hippo pathway plays a vital role in liver regeneration and development by determining cellular lineage and regulating cell proliferation and apoptosis. In this study, we aimed to assess the role of the Hippo pathway in hepatic carcinogenesis and morphogenesis by examining Yes-associated protein 1 (YAP1) expression in the spectrum of hepatic carcinomas based on cellular lineage. METHODS: We examined 913 primary hepatic carcinomas, including hepatocellular carcinomas (HCCs), combined hepatocellular and cholangiocarcinomas (cHC-CCAs), intrahepatic cholangiocarcinomas (IHCCAs) and perihilar extrahepatic bile duct carcinomas (EHBCAs)...
June 23, 2017: BMC Cancer
https://www.readbyqxmd.com/read/28640107/a-nomogram-prediction-of-postoperative-surgical-site-infections-in-patients-with-perihilar-cholangiocarcinoma
#10
Long Li, Jie Ding, Jun Han, Hong Wu
Surgical site infection (SSI) is one of the major morbidities after radical resection for perihilar cholangiocarcinoma (PHCC). This study aimed to clarify the risk factors and construct a nomogram to predict SSIs in patients with PHCC.A total of 335 consecutive patients who underwent hepatectomy combined with hepaticojejunostomy between January 2013 and December 2015 were analyzed retrospectively. SSIs, including incisional (superficial and deep) and space/organ infection, were defined according to the Centers for Disease Control and Prevention (CDC)'s National Nosocomial Infection Surveillance (NNIS) system...
June 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/28629770/application-of-the-laparoscopic-technique-in-perihilar-cholangiocarcinoma-surgery
#11
Jun Li, Lei Zhao, Jian Zhang, Zhengtian Li, Aidong Li, Yunwei Wei, Jun Xu
INTRODUCTION: The aim of this study is to investigate the feasibility of the application of the laparoscopic technique in perihilar cholangiocarcinoma. METHODS: A total of nine cases of patients who received laparoscopic perihilar cholangiocarcinoma surgery from January 2007 to May 2014 were retrospectively analyzed. The Bismuth subtypes consisted of one case of type I, three cases of type II, two cases of type IIIb, and three cases type IV. RESULTS: Radical resection was conducted in six cases: two cases (type II) with the caudate lobe resection, and two cases (type IIIb) with the left hepatectomy and caudate lobe resection...
June 16, 2017: International Journal of Surgery
https://www.readbyqxmd.com/read/28626373/biliary-pleural-fistula-following-portal-vein-embolization-for-perihilar-cholangiocarcinoma
#12
Mujtaba Mohammed, Katsuhiro Kobayashi, Mohammed Jawed
Biliary-pleural fistula (BPF), an abnormal communication between the biliary tract and pleural space, is a rare but potentially life-threatening complication following percutaneous biliary intervention. We report a case of BPF following portal vein embolization (PVE) in a 79-year-old woman with obstructive jaundice secondary to perihilar cholangiocarcinoma. The patient successfully underwent right-sided PVE; however, the patient developed a symptomatic right-sided bilious pleural effusion the following day...
May 2017: Case Reports in Gastroenterology
https://www.readbyqxmd.com/read/28624053/radiologic-evaluation-of-vasculobiliary-anatomy-in-the-umbilical-fissure
#13
Gu-Wei Ji, Fei-Peng Zhu, Ke Wang, Yong-Xiang Xia, Chen-Yu Jiao, Zi-Cheng Shao, Xiang-Cheng Li
BACKGROUND: Preoperative evaluation of vasculobiliary anatomy in the umbilical fissure (U-point) is pivotal for perihilar cholangiocarcinoma (PCCA) applied to right-sided hepatectomy. The purpose of our study was to review the vasculobiliary anatomy in the U-point using three-dimensional (3D) reconstruction technique, to investigate the diagnostic ability of 2D scans to evaluate anatomic variations, and to discuss its surgical implications. METHODS: A retrospective study of 159 patients with Bismuth type I, II, and IIIa PCCA, who received surgery at our institution from November 2012 to September 2016, was conducted...
June 15, 2017: Journal of Surgical Research
https://www.readbyqxmd.com/read/28588883/compliance-with-evidence-based-multidisciplinary-guidelines-on-perihilar-cholangiocarcinoma
#14
Robert Js Coelen, Joost Huiskens, Pim B Olthof, Eva Roos, Jimme K Wiggers, Annuska Schoorlemmer, Otto M van Delden, Heinz-Josef Klümpen, Erik Aj Rauws, Thomas M van Gulik
BACKGROUND: Discrepancies are often noted between management of perihilar cholangiocarcinoma (PHC) in regional hospitals and the eventual treatment plan in specialized centers. OBJECTIVE: The objective of this article is to evaluate whether regional centers adhere to guideline recommendations following implementation in 2013. METHODS: Data were analyzed from all consecutive patients with suspected PHC referred to our academic center between June 2013 and December 2015...
June 2017: United European Gastroenterology Journal
https://www.readbyqxmd.com/read/28588705/galnt14-genotype-is-associated-with-perineural-invasion-lymph-node-metastasis-and-overall-survival-in-resected-cholangiocarcinoma
#15
Kung-Hao Liang, Ta-Sen Yeh, Ren-Chin Wu, Chun-Nan Yeh, Chau-Ting Yeh
Cholangiocarcinoma is a rare, sporadic and aggressive type of cancer. The genetic basis of cholangiocarcinoma remains poorly understood. The present study investigated the prognostic role of the N-acetylgalactosaminyltransferase 14 (GALNT14)-rs9679162 genotype, an effective therapeutic response predictor for hepatocellular carcinoma in patients with cholangiocarcinoma receiving surgical resection. A cohort of patients with intrahepatic or perihilar cholangiocarcinoma (n=112) were retrospectively recruited. Of these patients, 31...
June 2017: Oncology Letters
https://www.readbyqxmd.com/read/28570102/cross-sectional-imaging-of-intrahepatic-cholangiocarcinoma-development-growth-spread-and-prognosis
#16
Nieun Seo, Do Young Kim, Jin-Young Choi
OBJECTIVE: Intrahepatic cholangiocarcinoma (ICC) is a malignant tumor that arises from the intrahepatic bile ducts. Although the pathologic and imaging features of ICC have been clearly identified, recent updates have addressed the pathologic classification and imaging features of ICC using new imaging techniques. First, a proposed new pathologic ICC subclassification includes perihilar large duct and peripheral small duct ICCs. Second, advanced MR-based imaging features of ICC, such as hepatobiliary phase imaging using hepatocytespecific contrast material and DWI, have recently been described...
August 2017: AJR. American Journal of Roentgenology
https://www.readbyqxmd.com/read/28566890/benefit-of-neoadjuvant-concurrent-chemoradiotherapy-for-locally-advanced-perihilar-cholangiocarcinoma
#17
Jang Han Jung, Hyun Jik Lee, Hee Seung Lee, Jung Hyun Jo, In Rae Cho, Moon Jae Chung, Jeong Youp Park, Seung Woo Park, Si Young Song, Seungmin Bang
AIM: To clarify the role of neoadjuvant concurrent chemoradiotherapy (NACCRT) followed by surgical resection for localized or locally advanced perihilar cholangiocarcinoma (CCA). METHODS: We retrospectively reviewed 57 patients who underwent surgical resection with or without NACCRT for perihilar CCA; 12 patients received NACCRT and 45 patients did not received NACCRT. Patients with locally advanced perihilar CCA requiring NACCRT were defined as follows: (1) a mass involving unilateral branches of the portal vein or hepatic artery with insufficient volume of the anticipated remnant lobe; or (2) an infiltrating mass in the main portal vein that was too long for reconstruction, identified at preoperative staging...
May 14, 2017: World Journal of Gastroenterology: WJG
https://www.readbyqxmd.com/read/28549744/survival-after-resection-of-perihilar-cholangiocarcinoma-in%C3%A2-patients-with-lymph-node-metastases
#18
Stefan Buettner, Jeroen L A van Vugt, Marcia P Gaspersz, Robert J S Coelen, Eva Roos, Tim A Labeur, Georgios A Margonis, Cecilia G Ethun, Shishir K Maithel, George Poultsides, Thuy Tran, Kamran Idrees, Chelsea A Isom, Ryan C Fields, Bradley A Krasnick, Sharon M Weber, Ahmed Salem, Robert C G Martin, Charles R Scoggins, Perry Shen, Harveshp D Mogal, Carl Schmidt, Eliza Beal, Ioannis Hatzaras, Rivfka Shenoy, Jan N M IJzermans, Thomas M van Gulik, Timothy M Pawlik, Bas Groot Koerkamp
BACKGROUND: The aim of this study was to compare patients with PHC with lymph node metastases (LN+) who underwent a resection with patients who did not undergo resection because of locally advanced disease at exploratory laparotomy. METHODS: Consecutive LN+ patients who underwent a resection for PHC in 12 centers were compared with patients who did not undergo resection because of locally advanced disease at exploratory laparotomy in 2 centers. RESULTS: In the resected cohort of 119 patients, the median overall survival (OS) was 19 months and the estimated 1-, 3- and 5-year OS was 69%, 27% and 13%, respectively...
May 23, 2017: HPB: the Official Journal of the International Hepato Pancreato Biliary Association
https://www.readbyqxmd.com/read/28547855/high-grade-dysplasia-carcinoma-in-situ-of-the-bile-duct-margin-in-patients-with-surgically-resected-node-negative-perihilar-cholangiocarcinoma-is-associated-with-poor-survival-a-retrospective-study
#19
Ryota Higuchi, Takehisa Yazawa, Shuichiro Uemura, Wataru Izumo, Toru Furukawa, Masakazu Yamamoto
BACKGROUND: The clinical relevance of a high-grade dysplasia/carcinoma in situ (HD/CIS)-positive bile duct margin in perihilar cholangiocarcinoma (PHC) is unclear. We evaluated the surgical outcomes of PHC patients with HD/CIS. METHODS: Clinicopathological data of 163 consecutive patients who underwent resection of PHC between 2004 and 2013 were analyzed retrospectively. RESULTS: Postoperative states included curative resection (R0) with free margins in 113 patients, non-curative resection with HD/CIS (R1-HD/CIS) in 22 patients, and non-curative resection with any invasive carcinoma margin in 28 patients...
May 26, 2017: Journal of Hepato-biliary-pancreatic Sciences
https://www.readbyqxmd.com/read/28532698/validation-of-the-mayo-clinic-staging-system-in-determining-prognoses-of-patients-with-perihilar-cholangiocarcinoma
#20
Robert J S Coelen, Marcia P Gaspersz, Tim A Labeur, Jeroen L A van Vugt, Susan van Dieren, François E J A Willemssen, Chung Y Nio, Jan N M IJzermans, Heinz-Josef Klümpen, Bas Groot Koerkamp, Thomas M van Gulik
BACKGROUND AND AIMS: Most systems for staging perihilar cholangiocarcinoma (PHC) have been developed for the minority of patients with resectable disease. The recently developed Mayo Clinic system for staging PHC requires only clinical and radiological variables, but has not yet been validated. We performed a retrospective study to validate the Mayo Clinic staging system. METHODS: We identified consecutive patients with suspected PHC evaluated and treated at 2 tertiary centers in The Netherlands, from January 2002 through December 2014...
May 19, 2017: Clinical Gastroenterology and Hepatology
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