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perihilar cholangiocarcinoma

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https://www.readbyqxmd.com/read/29779953/a-quality-assurance-device-for-measuring-afterloader-performance-and-transit-dose-for-nasobiliary-high-dose-rate-brachytherapy
#1
Christopher L Deufel, John P Mullins, Mark J Zakhary
PURPOSE: Nasobiliary high-dose-rate (HDR) brachytherapy has emerged as an effective tool to boost the radiation dose for patients with unresectable perihilar cholangiocarcinoma. This work describes a quality assurance (QA) tool for measuring the HDR afterloader's performance, including the transit dose, when the source wire travels through a tortuous nasobiliary catheter path. METHODS AND MATERIALS: The nasobiliary QA device was designed to mimic the anatomical path of a nasobiliary catheter, including the nasal, stomach, duodenum, and bile duct loops...
May 17, 2018: Brachytherapy
https://www.readbyqxmd.com/read/29779307/-application-of-perihilar-surgical-techniques-in-perihilar-biliary-tract-tumours
#2
J Wang
Perihilar biliary tract tumours include hilar cholangiocarcinoma, gallbladder cancer invading the hepatic hilum and intrahepatic cholangiocarcioma invading the hepatic hilum.The tumours have the special characteristics such as strong invasion capability, the anatomic variant, the pathophysiological complexity, the biological behavior diversity and the difficulty of preoperative evaluation which result in low R0 resection rate, more postoperative complications, more mortality and poor prognosis.The perihilar surgical techniques system aims to set a reasonable and individual operation procedure on the principle of precision surgery by taking the key technique of hilar dissection and exposing, evaluting the hilar anatomy by the means of three-dimensional digital medical image evaluation system, evaluting the relationship between the tumour and hepatic artery and portal vein under the condition of hepatic hilum complete exposure by combining anterograde and retrograde route from intra and extra-hepatic direction to hepatic hilum...
May 1, 2018: Zhonghua Wai Ke za Zhi [Chinese Journal of Surgery]
https://www.readbyqxmd.com/read/29756647/surgery-for-perihilar-cholangiocarcinoma
#3
B Groot Koerkamp, W R Jarnagin
No abstract text is available yet for this article.
June 2018: British Journal of Surgery
https://www.readbyqxmd.com/read/29752510/impact-of-biliary-drainage-on-multidetector-row-computed-tomography-on-r0-resection-of-perihilar-cholangiocarcinoma
#4
Isamu Hosokawa, Hiroaki Shimizu, Hideyuki Yoshitomi, Katsunori Furukawa, Tsukasa Takayashiki, Masaru Miyazaki, Masayuki Ohtsuka
BACKGROUND: Although multidetector-row computed tomography (MDCT) before biliary drainage is useful for the assessment of the resectability of perihilar cholangiocarcinoma (PHC), the impact of biliary drainage on MDCT images before surgical resection for PHC has been poorly studied, and its possible consequences for R0 resection of PHC remain unclear. This study was performed to compare the surgical outcomes of patients with PHC who underwent MDCT before versus after biliary drainage...
May 11, 2018: World Journal of Surgery
https://www.readbyqxmd.com/read/29747443/microsatellite-instability-occurs-rarely-in-patients-with-cholangiocarcinoma-a-retrospective-study-from-a-german-tertiary-care-hospital
#5
Ria Winkelmann, Markus Schneider, Sylvia Hartmann, Andreas A Schnitzbauer, Stefan Zeuzem, Jan Peveling-Oberhag, Martin Leo Hansmann, Dirk Walter
Immune-modulating therapy is a promising therapy for patients with cholangiocarcinoma (CCA). Microsatellite instability (MSI) might be a favorable predictor for treatment response, but comprehensive data on the prevalence of MSI in CCA are missing. The aim of the current study was to determine the prevalence of MSI in a German tertiary care hospital. Formalin-fixed paraffin-embedded tissue samples, obtained in the study period from 2007 to 2015 from patients with CCA undergoing surgical resection with curative intention at Johann Wolfgang Goethe University hospital, were examined...
May 9, 2018: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/29735023/liver-transplant-for-cholangiocarcinoma
#6
REVIEW
Daniel Zamora-Valdes, Julie K Heimbach
Liver transplant (LT) for perihilar cholangiocarcinoma (CCA) offers an opportunity for survival among patients with early-stage but anatomically unresectable disease. The 5-year survival rate after LT is 65% to 70%, higher among patients with primary sclerosing cholangitis, who are often diagnosed earlier, and lower among patients with de novo CCA. The results of LT for hilar CCA, along with recent limited data suggesting favorable survival among patients with very early intrahepatic CCA (ICC), have reignited interest in the subject...
June 2018: Gastroenterology Clinics of North America
https://www.readbyqxmd.com/read/29726723/surgical-approaches-for-the-treatment-of-perihilar-cholangiocarcinoma
#7
Charles W Kimbrough, Jordan M Cloyd, Timothy M Pawlik
Since their initial description, perihilar cholangiocarcinoma (pCCA) has remained one of the more clinically challenging scenarios encountered by hepatobiliary surgeons. Surgery remains the only potentially curative therapy, but requires complex, technically demanding operations with high associated morbidity and mortality. Over the last several decades, advances in surgical technique and perioperative management have improved patient outcomes. Areas Covered: Achievement of optimal outcomes requires a multidisciplinary approach from a team of providers with expertise in hepatobiliary and oncologic surgery, medical oncology, radiation oncology, and advanced gastroenterology...
May 4, 2018: Expert Review of Anticancer Therapy
https://www.readbyqxmd.com/read/29675965/il-33-overexpression-reflects-less-aggressive-tumour-features-in-large-duct-type-cholangiocarcinomas
#8
Ryuichiro Sawada, Yuna Ku, Masayuki Akita, Kyoko Otani, Kohei Fujikura, Tomoo Itoh, Tetsuo Ajiki, Takumi Fukumoto, Yoshihiro Kakeji, Yoh Zen
BACKGROUND & AIMS: The present study aimed to elucidate the clinicopathological significance of IL-6 and IL-33 expression in intrahepatic cholangiocarcinomas (iCCAs) and perihilar cholangiocarcinomas (pCCAs). METHODS: IL-6 and IL-33 mRNA expression was examined in iCCAs (n=55) and pCCAs (n=32) using quantitative real-time PCR and a highly sensitive in situ hybridization protocol (RNAscope® ), and expression values were correlated with clinicopathological features...
April 19, 2018: Histopathology
https://www.readbyqxmd.com/read/29627334/preoperative-risk-score-to-predict-occult-metastatic-or-locally-advanced-disease-in-patients-with-resectable-perihilar-cholangiocarcinoma-on-imaging
#9
Jimme K Wiggers, Bas Groot Koerkamp, David van Klaveren, Robert J Coelen, C Yung Nio, Peter J Allen, Marc G Besselink, Olivier R Busch, Michael I D'Angelica, Ronald P DeMatteo, T Peter Kingham, Thomas M van Gulik, William R Jarnagin
BACKGROUND: Many patients with resectable perihilar cholangiocarcinoma (PHC) on imaging are intra-operatively diagnosed with occult metastatic or locally advanced disease precluding a curative-intent resection. This study aimed to develop and validate a preoperative risk score. STUDY DESIGN: Patients with resectable PHC on imaging who underwent surgery in two high-volume centers (USA and Europe) between 2000 and 2015 were included. Multivariable logistic regression analysis was used to develop the risk score...
April 5, 2018: Journal of the American College of Surgeons
https://www.readbyqxmd.com/read/29599608/intraoperative-frozen-section-diagnosis-of-bile-duct-margin-for-extrahepatic-cholangiocarcinoma
#10
Takayuki Shiraki, Hajime Kuroda, Atsuko Takada, Yoshimasa Nakazato, Keiichi Kubota, Yasuo Imai
AIM: To evaluate the usefulness of frozen section diagnosis (FSD) of bile duct margins during surgery for extrahepatic cholangiocarcinoma (CCA). METHODS: We retrospectively analyzed 74 consecutive patients who underwent surgery for extrahepatic CCA from 2012 to 2017, during which FSD of bile duct margins was performed. They consisted of 40 distant and 34 perihilar CCAs (45 and 55 bile duct margins, respectively). The diagnosis was classified into three categories: negative, borderline (biliary intraepithelial neoplasia-1 and 2, and indefinite for neoplasia), or positive...
March 28, 2018: World Journal of Gastroenterology: WJG
https://www.readbyqxmd.com/read/29573451/dataset-for-the-reporting-of-intrahepatic-cholangiocarcinoma-perihilar-cholangiocarcinoma-and-hepatocellular-carcinoma-recommendations-from-the-international-collaboration-on-cancer-reporting-iccr
#11
REVIEW
Alastair D Burt, Venâncio Alves, Pierre Bedossa, Andrew D Clouston, Maria Guido, Stefan G Hübscher, Sanjay Kakar, Irene O Ng, Young Nyun Park, Helen L Reeves, Judith Wyatt, Matthew M Yeh, David W Ellis
Optimal patient management benefits from comprehensive and accurate pathology reports that contribute to cancer staging and prognostication. In many countries, proforma reports are used but these vary in their structure and implementation. The International Collaboration on Cancer Reporting (ICCR) is an alliance formed by the Royal College of Pathologists of Australasia, the Royal College of Pathologists of the United Kingdom, the College of American Pathologists, the Canadian Partnership Against Cancer the European Society of Pathology, and the American Society of Clinical Pathology (ASCP) with the aim of developing an evidence-based reporting data set for each cancer site...
March 24, 2018: Histopathology
https://www.readbyqxmd.com/read/29549357/igg4-associated-cholangitis-in-patients-resected-for-presumed-perihilar-cholangiocarcinoma-a-30-year-tertiary-care-experience
#12
Eva Roos, Lowiek M Hubers, Robert J S Coelen, Marieke E Doorenspleet, Niek de Vries, Joanne Verheij, Ulrich Beuers, Thomas M van Gulik
BACKGROUND: Distinguishing perihilar cholangiocarcinoma (PHC) from benign forms of sclerosing cholangitis affecting the hilar bile ducts is challenging, since histological confirmation of PHC is difficult to obtain and accurate non-invasive diagnostic tests are not available. IgG4-associated cholangitis (IAC), an imitator of PHC, may present with clinical and radiographical signs of PHC. IAC can be accurately diagnosed with a novel qPCR test. The aim of this study was to investigate the incidence and long-term activity of IAC in patients resected for PHC in a single tertiary center over a period of 30 years...
March 16, 2018: American Journal of Gastroenterology
https://www.readbyqxmd.com/read/29511556/preoperative-prediction-of-curative-surgery-of-perihilar-cholangiocarcinoma-by-combination-of-endoscopic-ultrasound-and-computed-tomography
#13
Sara Kammerer, Tobias Meister, Heiner Wolters, Matthias Lessing, Anna Hüsing, Dirk Domagk, Martin Floer, Christian Wilms, Hartmut Schmidt, Norbert Senninger, Gabriele Köhler, Hauke Sebastian Heinzow
Background: Perihilar cholangiocarcinomas are often considered incurable. Late diagnosis is common. Advanced disease therefore frequently causes questioning of curative surgical outcome. Aim: This study aimed to develop a prediction model of curative surgery in patients suffering from perihilar cholangiocarcinomas based on preoperative endosonography and computer tomography. Methods: A cohort of 81 patients (median age 67 (54-75) years, 62% male) with perihilar cholangiocarcinoma was retrospectively analyzed...
March 2018: United European Gastroenterology Journal
https://www.readbyqxmd.com/read/29502573/perihilar-cholangiocarcinoma
#14
Meryl C Nath, Michael S Torbenson, Lori A Erickson
No abstract text is available yet for this article.
March 2018: Mayo Clinic Proceedings
https://www.readbyqxmd.com/read/29488187/adjuvant-therapy-is-associated-with-improved-survival-in-resected-perihilar-cholangiocarcinoma-a-propensity-matched-study
#15
Ibrahim Nassour, Ali A Mokdad, Matthew R Porembka, Michael A Choti, Patricio M Polanco, John C Mansour, Rebecca M Minter, Sam C Wang, Adam C Yopp
BACKGROUND: There are limited well-controlled studies that conclusively demonstrate a benefit of adjuvant therapy in resected perihilar cholangiocarcinoma. Most studies include all biliary tract tumors as one entity despite the heterogeneity of these diseases. METHODS: We identified patients with resected perihilar cholangiocarcinoma from the National Cancer Database between 2006 and 2013. Patients who received adjuvant therapy (AT) were compared to an observation (OB) cohort by propensity score matching...
May 2018: Annals of Surgical Oncology
https://www.readbyqxmd.com/read/29480952/neoadjuvant-hyperfractionated-chemoradiation-and-liver-transplantation-for-unresectable-perihilar-cholangiocarcinoma-in-canada
#16
Benjamin P T Loveday, Jennifer J Knox, Laura A Dawson, Ur Metser, Anthony Brade, Anne M Horgan, Steven Gallinger, Paul D Greig, Carol-Anne Moulton
BACKGROUND AND OBJECTIVES: Neoadjuvant chemoradiation and liver transplantation may be offered for unresectable perihilar cholangiocarcinoma (pCCA). This study aimed to determine the dropout rate and survival of patients who entered a national tri-modality protocol. METHOD: Patients enrolled Jan 2009-Aug 2015 were included. Enrolment criteria: ≤65 years, brush biopsy-proven unresectable pCCA <3.5 cm diameter. Conformal radiotherapy was given concurrently with Capecitabine...
February 2018: Journal of Surgical Oncology
https://www.readbyqxmd.com/read/29464308/-intrahepatic-cholangiocarcinoma-results-after-84-resections
#17
H P Neeff, P A Holzner, M Menzel, P Bronsert, A Klock, S A Lang, S Fichtner-Feigl, U T Hopt, F Makowiec
BACKGROUND: The incidence of intrahepatic cholangiocarcinoma (ICC) is increasing worldwide. Surgical resection is the only curative treatment option. AIM OF THE STUDY: This study analyzed the prognostic factors after resection of ICC. MATERIAL AND METHODS: A total of 84 patients were surgically treated under potentially curative intent. Perihilar and distal cholangiocarcinomas were excluded. The 5‑year survival was analyzed with respect to tumor stage (TNM), number of lesions, complete surgical resection (R0), peritoneal carcinosis and postoperative complications...
May 2018: Der Chirurg; Zeitschrift Für Alle Gebiete der Operativen Medizen
https://www.readbyqxmd.com/read/29458151/endoscopic-management-of-pancreatobiliary-neoplasms
#18
Andrew Y Wang, Patrick S Yachimski
Endoscopic ultrasound (EUS) and endoscopic retrograde cholangiopancreatography (ERCP) are the mainstays of interventional endoscopic practice. EUS occupies a central role in the diagnosis of pancreatobiliary neoplasms and offers a platform for a wide range of direct tumor therapies. Initial steps have demonstrated the feasibility of such applications in animal models and pilot studies. Larger clinical trials and incorporation of EUS-based therapies into cooperative cancer studies might demonstrate an impact in the clinical prognosis of patients with pancreatic cancer...
May 2018: Gastroenterology
https://www.readbyqxmd.com/read/29455204/low-skeletal-muscle-density-is-associated-with-early-death-in-patients-with-perihilar-cholangiocarcinoma-regardless-of-subsequent-treatment
#19
Jeroen L A van Vugt, Marcia P Gaspersz, Jaynee Vugts, Stefan Buettner, Stef Levolger, Ron W F de Bruin, Wojciech G Polak, Jeroen de Jonge, François E J A Willemssen, Bas Groot Koerkamp, Jan N M IJzermans
BACKGROUND: Low skeletal muscle mass is associated with increased postoperative morbidity and worse survival following resection for perihilar cholangiocarcinoma (PHC). We investigated the predictive value of skeletal muscle mass and density for overall survival (OS) of all patients with suspected PHC, regardless of treatment. METHODS: Baseline characteristics and parameters regarding disease and treatment were collected from all patients with PHC from 2002 to 2014...
February 16, 2018: Digestive Surgery
https://www.readbyqxmd.com/read/29421802/postoperative-liver-failure-criteria-for-predicting-mortality-after-major-hepatectomy-with-extrahepatic-bile-duct-resection
#20
Takeshi Kawamura, Takehiro Noji, Keisuke Okamura, Kimitaka Tanaka, Yoshitsugu Nakanishi, Toshimichi Asano, Yuma Ebihara, Yo Kurashima, Toru Nakamura, Soichi Murakami, Takahiro Tsuchikawa, Toshiaki Shichinohe, Satoshi Hirano
BACKGROUND: Post-hepatectomy liver failure (PHLF) is a serious complication after major hepatectomy with extrahepatic bile duct resection (Hx with EBDR) that may cause severe morbidity and even death. The purpose of this study was to compare several criteria systems as predictors of PHLF-related mortality following Hx with EBDR for perihilar cholangiocarcinoma (PHCC). METHODS: The study cohort consisted of 222 patients who underwent Hx with EBDR for PHCC. We compared several criteria systems, including previously established criteria (the International Study Group of Liver Surgery (ISGLS) criterion; and the "50-50" criterion), and our institution's novel systems "Max T-Bili" defined as total bilirubin (T-Bili) >7...
February 8, 2018: Digestive Surgery
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