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gestational diabetes and atypical antipsychotics

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https://www.readbyqxmd.com/read/27512491/life-threatening-ketoacidosis-in-a-pregnant-woman-with-psychotic-disorder
#1
Charlotte Frise, Ben Attwood, Peter Watkinson, Lucy Mackillop
Pregnancy is an insulin resistant state. Hyperglycaemia and gestational diabetes mellitus are well-recognised complications even in women without existing metabolic syndrome or obesity. Pregnant women also appear to be more vulnerable to ketoacidosis, particularly after short periods of reduced oral intake in the third trimester, and may present with very severe starvation ketoacidosis, prompting emergent delivery. We present a case of a woman with a background of depression and psychotic episodes. Olanzapine had been commenced after a psychotic episode at 20 weeks' gestation...
March 2016: Obstetric Medicine
https://www.readbyqxmd.com/read/27484686/risks-associated-with-antipsychotic-treatment-in-pregnancy-comparative-cohort-studies-based-on-electronic-health-records
#2
Irene Petersen, Cormac J Sammon, Rachel L McCrea, David P J Osborn, Stephen J Evans, Phillip J Cowen, Irwin Nazareth
BACKGROUND: Limited information is available on whether antipsychotics prescribed in pregnancy are associated with increased risks of adverse outcomes. METHODS: We used electronic health records from pregnant women and their children to examine risks of adverse maternal and child outcomes in three cohorts of women who: (A) received antipsychotic treatment in pregnancy (n=416) (B) discontinued antipsychotic treatment before pregnancy (n=670), and (C) had no records of antipsychotic treatment before or during pregnancy (n=318,434)...
October 2016: Schizophrenia Research
https://www.readbyqxmd.com/read/26001182/antipsychotic-use-in-pregnancy
#3
REVIEW
Jayashri Kulkarni, Adele Storch, Analin Baraniuk, Heather Gilbert, Emmy Gavrilidis, Roisin Worsley
INTRODUCTION: Antipsychotic medications are being prescribed for a growing number of women with mental illnesses. However, evidence regarding their safety in pregnancy is still insufficient to provide adequate support for clinical practice, creating increasing concern among pregnant women and clinicians. AREAS COVERED: The aim of this article is to review published data regarding the safety of antipsychotic medications in pregnancy with a focus on the most commonly used atypical antipsychotics...
June 2015: Expert Opinion on Pharmacotherapy
https://www.readbyqxmd.com/read/21088587/drug-treatment-for-mood-disorders-in-pregnancy
#4
REVIEW
Salvatore Gentile
PURPOSE OF REVIEW: During the last few years, several researches, often showing contradictory findings, have investigated the safety of psychotropic medications used for treating mood disorders in pregnancy. Hence, the necessity exists to update this information constantly in order to ensure the safest option for the mother-infant pair. RECENT FINDINGS: The risk of fetal anomalies associated with early in-utero exposure to antidepressants seems to be increased after paroxetine and clorimipramine exposure, whereas prenatal exposure to nearly all antidepressants is linked to the potential onset of the Prenatal Antidepressant Exposure Syndrome...
January 2011: Current Opinion in Psychiatry
https://www.readbyqxmd.com/read/20465753/antipsychotics-in-pregnancy
#5
REVIEW
K McCauley-Elsom, C Gurvich, S J Elsom, J Kulkarni
Women who are pregnant and who have a history of psychosis are commonly managed with antipsychotic medications. The evidence regarding the use of antipsychotics in pregnancy has been insufficient to provide adequate support for this practice and is a concern for clinicians and women alike. This review presents literature surrounding the use of antipsychotic medications in pregnancy, providing an overview of the historical and contemporary perspectives which influence clinicians prescribing practices. Data were sourced from Medline, CINAHL, PsycINFo, using the terms antipsychotics with pregnancy and psychosis or schizophrenia...
March 2010: Journal of Psychiatric and Mental Health Nursing
https://www.readbyqxmd.com/read/18480684/maternal-use-of-antipsychotics-in-early-pregnancy-and-delivery-outcome
#6
COMPARATIVE STUDY
Margareta Reis, Bengt Källén
The effect of various antipsychotics during pregnancy has repeatedly been studied, but for most atypical antipsychotics, only little information is available. We identified from the Swedish Medical Birth Register 2908 women who had reported the use of any antipsychotic or lithium in early pregnancy and studied malformation rates with data also from the Register of Congenital Malformations and the Hospital Discharge Register. Comparisons were made with all births (n = 958,729) after adjustment for some confounders...
June 2008: Journal of Clinical Psychopharmacology
https://www.readbyqxmd.com/read/14567163/-clozapine-and-pregnancy
#7
REVIEW
H N Nguyen, P Lalonde
UNLABELLED: This article reviews the relations between clozapine and pregnancy. Six case reports are identified in the literature of pregnant patients who received clozapine. Novartis at Basle, Switzerland, through its pharmacovigilance and epidemiology, service, has data on nearly 200 cases summarized in this article. We also describe the case of a patient with paranoid schizophrenia who was hospitalized 10 times between the age of 22 to 32. She received clozapine when she was 29 years old and, with a daily dosage of 350 mg, she became asymptomatic...
March 2003: L'Encéphale
https://www.readbyqxmd.com/read/9712217/pregnancy-of-a-patient-treated-with-clozapine
#8
R A Dickson, L Hogg
The authors describe the case of a patient with treatment-resistant schizophrenia who became pregnant after switching from conventional neuroleptic medications to clozapine, an atypical antipsychotic medication that does not cause hyperprolactinemia. Gestational diabetes, possibly exacerbated by clozapine, complicated management of her pregnancy. Comprehensive community support and psychiatric rehabilitation, combined with a positive response to clozapine, contributed to satisfying the patient's goal of having a healthy baby and being able to take the baby home to live with her and her husband...
August 1998: Psychiatric Services: a Journal of the American Psychiatric Association
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