Tao Zhang, Philipp Seeger, Yashin Simsek, Morsal Sabihi, Jöran Lücke, Dimitra E Zazara, Ahmad Mustafa Shiri, Jan Kempski, Tom Blankenburg, Lilan Zhao, Ioannis Belios, Andres Machicote, Baris Mercanoglu, Mohammad Fard-Aghaie, Sara Notz, Panagis M Lykoudis, Marius Kemper, Tarik Ghadban, Oliver Mann, Thilo Hackert, Jakob R Izbicki, Thomas Renné, Samuel Huber, Anastasios D Giannou, Jun Li
BACKGROUND: Insufficient remnant liver volume (RLV) after the resection of hepatic malignancy could lead to liver failure and mortality. Portal vein ligation (PVL) prior to hepatectomy is subsequently introduced to increase the remnant liver volume and improve the outcome of hepatic malignancy. IL-22 has previously been reported to promote liver regeneration, while facilitating tumor development in the liver via Steap4 upregulation. Here we performed PVL in mouse models to study the role of IL-22 in liver regeneration post-PVL...
March 30, 2024: Heliyon