keyword
MENU ▼
Read by QxMD icon Read
search

Il 6

keyword
https://www.readbyqxmd.com/read/29224017/the-il-2-anti-il-2-complex-attenuates-cardiac-ischaemia-reperfusion-injury-through-expansion-of-regulatory-t-cells
#1
Junhui Xiao, Kunwu Yu, Ming Li, Chuanyin Xiong, Yuzhen Wei, Qiutang Zeng
BACKGROUND/AIMS: Regulatory T cells (Tregs) can suppress immunologic damage in myocardial ischaemia/reperfusion injury (MIRI), however, the isolation and ex vivo expansion of these cells for clinical application remains challenging. Here, we investigated whether the IL-2/anti-IL-2 complex (IL-2C), a mediator of Treg expansion, can attenuate MIRI in mice. METHODS: Myocardial I/R was surgically induced in male C57BL/6 mice, aged 8-10 weeks, that were randomly assigned to 1) sham group (Sham), 2) Phosphate Buffered Saline (PBS), 3) IL-2-anti-IL-2 Ab complex (IL-2C), or 4) sham group, 5) PBS, 6) IL-2C after MIRI, or 7) IL-2C, 8) IL-2C+anti-CD25 mAbs, or 9) IL-2C; 10) IL-2C+anti-TGF-β1 mAbs, 11) IL-2C+anti-IL-10 mAbs...
December 7, 2017: Cellular Physiology and Biochemistry
https://www.readbyqxmd.com/read/29224015/renal-resistive-index-as-a-novel-indicator-for-renal-complications-in-high-fat-diet-fed-mice
#2
Hairong Xu, Zejun Ma, Shan Lu, Rui Li, Liangkun Lyu, Lexi Ding, Qiulun Lu
BACKGROUND/AIMS: The renal resistive index (RI) is a novel candidate as a renal injury prognostic indicator, but it remains unclear how renal RI levels correspond to renal injury in diabetic nephropathy. METHODS: To examine this issue, we compared 8-week-old male C57BL/6 mice fed with high-fat diet (HFD) versus chow diet (CHD) for 16 weeks. At 8 and 12 weeks, the glomerular filtration rate (GFR), urinary albumin-to-creatinine ratio (UACR), and inflammatory factors (IL-1β, IL-6, TNFα, and MCP-1) were measured, along with the increase in renal RI...
December 7, 2017: Kidney & Blood Pressure Research
https://www.readbyqxmd.com/read/29224009/itraq-based-proteomics-analysis-of-acute-lung-injury-induced-by-oleic-acid-in-mice
#3
Xiaotao Xu, Qingwei Zhu, Rong Zhang, Yan Wang, Fangfang Niu, Wenying Wang, Dawei Sun, Aizhong Wang
BACKGROUND/AIMS: This study was conducted to investigate the relationship between differentially expressed proteins (DEPs) and the pathogenesis of oleic acid (OA)-induced acute lung injury (ALI) in mice. METHODS: Eight-week-old male C57BL/6 mice were injected with OA through the tail vein and sacrificed 6 hours after OA administration to identify protein expression levels in lung tissue using isobaric tags for relative and absolute quantification (iTRAQ) technology...
December 8, 2017: Cellular Physiology and Biochemistry
https://www.readbyqxmd.com/read/29223854/baicalein-improves-liver-inflammation-in-diabetic-db-db-mice-by-regulating-hmgb1-tlr4-nf-%C3%AE%C2%BAb-signaling-pathway
#4
Huafeng Yin, Lihao Huang, Ting Ouyang, Lvyi Chen
The current study was designed to investigate the hepatoprotective effects and possible mechanisms of Baicalein (BA) on the diabetic liver injury in vivo and in vitro. The results exhibited that BA significantly restored the blood glucose in oral glucose tolerance test (OGTT) and inhibited the levels of insulin, alanine aminotransferase (ALT), aspartate aminotransaminase (AST), total cholesterol (TC) and triglyceride (TG) in C57BL/KsJ-db/db mice. Moreover, BA strikingly attenuated the extent of steatosis in the liver tissues of diabetic mice...
December 7, 2017: International Immunopharmacology
https://www.readbyqxmd.com/read/29223817/elevated-inflammatory-lp-pla2-and-il-6-link-e-waste-pb-toxicity-to-cardiovascular-risk-factors-in-preschool-children
#5
Xueling Lu, Xijin Xu, Yu Zhang, Yuling Zhang, Chenyang Wang, Xia Huo
Cardiovascular toxicity of lead (Pb) manifests primarily as an effect on blood pressure and eventual increased risk of atherosclerosis and cardiovascular events. Therefore, we investigated vascular inflammatory biomarkers and cardiovascular effects of Pb-exposed children. A total of 590 children (3-7 years old) were recruited from Guiyu (n = 337), an electronic waste (e-waste)-exposed group, and Haojiang (n = 253), a reference group, from November to December 2016. We measured child blood Pb levels (BPbs), and systolic and diastolic blood pressure...
December 7, 2017: Environmental Pollution
https://www.readbyqxmd.com/read/29223540/protective-effect-of-coptisine-free-base-on-indomethacin-induced-gastric-ulcers-in-rats-characterization-of-potential-molecular-mechanisms
#6
Chaodan Luo, Hanbin Chen, Yongfu Wang, Guosheng Lin, Cailan Li, Lihua Tan, Ziren Su, Xiaoping Lai, Jianhui Xie, Huifang Zeng
AIMS: The aim of this study was to comparatively investigate the potential gastroprotective effect and underlying mechanisms of coptisine free base (CFB, 8-hydroxy-7, 8-dihydrocoptisine), berberine and lansoprazole against indomethacin-induced gastric ulcer in rats. MATERIALS AND METHODS: CFB (10, 20 and 40mg/kg), berberine (20mg/kg) and lansoprazole (30mg/kg) were orally administrated to rats prior to indometacin ingestion, and gastric lesions were evaluated macroscopically and histologically, and further analyzed by ELISA, qRT-PCR and Western blot...
December 6, 2017: Life Sciences
https://www.readbyqxmd.com/read/29223534/systemic-recovery-and-therapeutic-effects-of-transplanted-allogenic-and-xenogenic-mesenchymal-stromal-cells-in-a-rat-blunt-chest-trauma-model
#7
Elisa Maria Amann, Markus Thomas Rojewski, Sinja Rodi, Daniel Fürst, Jörg Fiedler, Annette Palmer, Sonja Braumüller, Markus Huber-Lang, Hubert Schrezenmeier, Rolf Erwin Brenner
BACKGROUND: Effective therapy of Acute Lung Injury (ALI) is still a major scientific and clinical problem. To define novel therapeutic strategies for sequelae of blunt chest trauma (TxT) like ALI/Acute Respiratory Distress Syndrome, we have investigated the immunomodulatory and regenerative effects of a single dose of ex vivo expanded human or rat mesenchymal stromal cells (hMSCs/rMSCs) with or without priming, immediately after the induction of TxT in Wistar rats. METHODS: We analyzed the histological score of lung injury, the cell count of the broncho alveolar lavage fluid (BAL), the change in local and systemic cytokine level and the recovery of the administered cells 24 h and 5 days post trauma...
December 6, 2017: Cytotherapy
https://www.readbyqxmd.com/read/29223372/diagnostic-and-prognostic-plasma-biomarkers-for-idiopathic-pneumonia-syndrome-after-hematopoietic-cell-transplantation
#8
Sachiko Seo, Jeffrey Yu, Isaac C Jenkins, Wendy M Leisenring, Terry Steven-Ayers, Jane M Kuypers, Meei-Li Huang, Keith R Jerome, Michael Boeckh, Sophie Paczesny
Idiopathic pneumonia syndrome (IPS) is a non-infectious pulmonary complication after hematopoietic cell transplantation (HCT) and is difficult to diagnose. We evaluated six candidate proteins in plasma samples at day 7 after HCT and at onset of IPS from 41 IPS cases to identify potential IPS diagnostic or prognostic biomarkers. Samples at similar times from 162 HCT recipients without documented infections and 37 HCT recipients with respiratory viral pneumonia served as controls. In multivariable models, a combination of Stimulation-2 (ST2, OR 2...
December 6, 2017: Biology of Blood and Marrow Transplantation
https://www.readbyqxmd.com/read/29223308/what-we-have-lost-mastitis-resistance-in-holstein-friesians-and-in-a-local-cattle-breed
#9
Giulio Curone, Joel Filipe, Paola Cremonesi, Erminio Trevisi, Massimo Amadori, Claudia Pollera, Bianca Castiglioni, Lauretta Turin, Vittorio Tedde, Daniele Vigo, Paolo Moroni, Andrea Minuti, Valerio Bronzo, M Filippa Addis, Federica Riva
In Holstein Friesian dairy cows, selective pressure for increased milk production has led to a higher propensity to disease, including mastitis, when compared to less selected and lower producing dairy breeds. The biology underpinning the higher resistance to disease of such "local breeds" is not fully understood. With the aim of investigating the factors associated to this phenomenon, we applied a multidisciplinary approach to compare innate immune response patterns, metabolic parameters, milk protein profiles and the milk microbiota in Holstein Friesian and Rendena cows reared in the same farm and under the same management conditions...
November 29, 2017: Research in Veterinary Science
https://www.readbyqxmd.com/read/29223294/glucocorticoid-hormone-treatment-enhances-the-cytokine-production-of-regulatory-t-cells-by-upregulation-of-foxp3-expression
#10
Emese Ugor, Lilla Prenek, Ramóna Pap, Gergely Berta, Dávid Ernszt, József Najbauer, Péter Németh, Ferenc Boldizsár, Tímea Berki
OBJECTIVE: Despite the fact that glucocorticoids (GC) are important therapeutic tools, their effects on regulatory T cells (Treg) are not well defined. The aim of our work was to investigate how GCs influence in vivo the thymic (tTreg) and peripheral Treg (pTreg) differentiation, survival and cytokine production. METHODS: Tregs were detected with flow cytometry in lymphatic organs of 4-6 weeks old BALB/c mice after repeated (2-4days), high-dose in vivo GC treatment using CD4/CD25 cell surface and Foxp3/IL-10/TGFβ/glucocorticoid receptor (GR) intracellular staining...
October 6, 2017: Immunobiology
https://www.readbyqxmd.com/read/29223158/salusin-%C3%AE-attenuates-inflammatory-responses-in-vascular-endothelial-cells
#11
Maryam Esfahani, Masoud Saidijam, Mohammad Taghi Goodarzi, Ahmad Movahedian, Rezvan Najafi
Atherosclerosis accounts for numerous cardiovascular diseases, and cytokines have a critical role in acceleration or suppression of disease. Salusin-α presents a new class of bioactive peptides that can have anti-atherogenic properties. Therefore, the effects of salusin-α on the expression of some pro- and anti-inflammatory cytokines and on TNF-α-induced inflammatory responses in human umbilical vein endothelial cells (HUVECs) were examined. The involvement of the NF-κB pathway in effects of salusin-α in HUVECs was checked using Bay 11-7082 as an NF-κB inhibitor...
November 2017: Biochemistry. Biokhimii︠a︡
https://www.readbyqxmd.com/read/29223071/bioactive-potential-of-silica-coatings-and-its-effect-on-the-adhesion-of-proteins-to-titanium-implants
#12
F Romero-Gavilan, N Araújo-Gomes, A M Sánchez-Pérez, I García-Arnáez, F Elortza, M Azkargorta, J J Martín de Llano, C Carda, M Gurruchaga, J Suay, I Goñi
There is an ever-increasing need to develop dental implants with ideal characteristics to achieve specific and desired biological response in the scope of improve the healing process post-implantation. Following that premise, enhancing and optimizing titanium implants through superficial treatments, like silica sol-gel hybrid coatings, are regarded as a route of future research in this area. These coatings change the physicochemical properties of the implant, ultimately affecting its biological characteristics...
December 6, 2017: Colloids and Surfaces. B, Biointerfaces
https://www.readbyqxmd.com/read/29222987/frequency-and-correlates-of-tardive-dyskinesia-in-indian-patients-with-type-i-bipolar-disorder
#13
Tess Maria Rajan, Balaji Bharadwaj, Ravi Philip Rajkumar, Prashant Shankarrao Adole
BACKGROUND: Patients with Bipolar Disorder (BD) may have higher risk of Tardive Dyskinesia (TD). Theories for TD include inflammatory or oxidative stress and altered iron metabolism. The current frequency and clinical and biochemical correlates of TD in BD needs exploration. OBJECTIVES: To assess: (1) the frequency of TD in BD; (2) clinical correlates of TD in BD; (3) oxidative stress markers, inflammatory markers and hepcidin in TD in BD. MATERIALS & METHODS: In this cross-sectional study, 170 patients with BD were assessed for clinical characteristics using structured assessments...
December 5, 2017: Asian Journal of Psychiatry
https://www.readbyqxmd.com/read/29222947/safety-and-efficacy-of-guselkumab-in-japanese-patients-with-moderate-to-severe-plaque-psoriasis-a-randomised-placebo-controlled-ascending-dose-study
#14
O Nemoto, K Hirose, S Shibata, K Li, H Kubo
BACKGROUND: The Interlukin-23 (IL-23)/Interlukin-17 (IL-17) pathway is central in the pathogenesis of psoriasis. The favourable efficacy and safety of guselkumab, an IL-23 specific monoclonal antibody, has been demonstrated in global Phase 3 studies of plaque psoriasis. OBJECTIVES: To evaluate the safety, efficacy and pharmacokinetics of a single-dose subcutaneous guselkumab in Japanese patients with moderate-to-severe plaque psoriasis. METHODS: Patients with ≥ 10% of total body surface area (BSA) involvement and a Psoriasis Area and Severity Index (PASI) ≥12 were randomised (5:1) to receive guselkumab or placebo in 4 cohorts of this double-blind, placebo-controlled, single ascending dose, single-centre study...
December 9, 2017: British Journal of Dermatology
https://www.readbyqxmd.com/read/29222643/overexpression-of-sirt2-alleviates-neuropathic-pain-and-neuroinflammation-through-deacetylation-of-transcription-factor-nuclear-factor-kappa-b
#15
Yong Zhang, Dachao Chi
Sirtuin 2 (SIRT2), a member of the mammalian sirtuin family, plays an important role in the pathogenesis of various neurological diseases. However, whether SIRT2 is involved in the regulation of neuropathic pain remains unclear. In this study, we aimed to investigate the potential role of SIRT2 in regulating neuropathic pain in a rat model induced by chronic constriction injury (CCI). We found that SIRT2 was downregulated in the dorsal root ganglion (DRG) in CCI rats. Intrathecal injection of a recombinant adenovirus expressing SIRT2 markedly alleviated mechanical allodynia and thermal hyperalgesia in CCI rats...
December 8, 2017: Inflammation
https://www.readbyqxmd.com/read/29222622/toll-like-receptor-4-knockdown-attenuates-brain-damage-and-neuroinflammation-after-traumatic-brain-injury-via-inhibiting-neuronal-autophagy-and-astrocyte-activation
#16
Hongsheng Jiang, Yanzhou Wang, Xin Liang, Xiaofeng Xing, Xiuzhen Xu, Caifeng Zhou
Toll-like receptor 4 (TLR4) has been linked to various pathophysiological conditions, such as traumatic brain injury (TBI). It is reported that posttraumatic neuroinflammation is an essential event in the progression of brain injury after TBI. Recent evidences indicate that TLR4 mediates glial phagocytic activity and inflammatory cytokines production. Thus, TLR4 may be an important therapeutic target for neuroinflammatory injury post-TBI. This study was designed to explore potential effects and underlying mechanisms of TLR4 in rats suffered from TBI...
December 8, 2017: Cellular and Molecular Neurobiology
https://www.readbyqxmd.com/read/29222448/effect-of-qianghuo-erhuang-decoction-on-t-regulatory-and-t-helper-17-cells-in-treatment-of-adjuvant-induced-arthritis-in-rats
#17
Can Qian, Mei Kuang, Yong Wang
QianghuoErhuang Decoction (QED) is an effective recipe in treating rheumatoid arthritis. The present study aimed to explore the effects of QED on Treg and Th17 in adjuvant arthritis (AA) model. The study included 6 group rats: normal control group, AA group, AA + methotrexate (MTX) group, AA + high, moderate, and low dose QED groups. The arthritis score was significantly decreased in the MTX and high-dose QED groups compared with the AA group on days 24 and 28 (P < 0.01), respectively. The synovial tissue inflammation was attenuated by histological observation, and the proliferation of splenocytes was significantly inhibited in MTX and high-dose QED groups (P < 0...
December 8, 2017: Scientific Reports
https://www.readbyqxmd.com/read/29222421/the-transcriptomic-signature-of-disease-development-and-progression-of-nonalcoholic-fatty-liver-disease
#18
Sophie Cazanave, Alexei Podtelezhnikov, Kristian Jensen, Mulugeta Seneshaw, Divya P Kumar, Hae-Ki Min, Prasanna K Santhekadur, Bubu Banini, Adolfo Gabriele Mauro, Abdul M Oseini, Robert Vincent, Keith Q Tanis, Andrea L Webber, Liangsu Wang, Pierre Bedossa, Faridoddin Mirshahi, Arun J Sanyal
A longitudinal molecular model of the development and progression of nonalcoholic fatty liver disease (NAFLD) over time is lacking. We have recently validated a high fat/sugar water-induced animal (an isogenic strain of C57BL/6 J:129S1/SvImJ mice) model of NAFLD that closely mimics most aspects of human disease. The hepatic transcriptome of such mice with fatty liver (8 weeks), steatohepatitis with early fibrosis (16-24 weeks) and advanced fibrosis (52 weeks) after initiation of the diet was evaluated and compared to mice on chow diet...
December 8, 2017: Scientific Reports
https://www.readbyqxmd.com/read/29222167/cytoplasmic-linker-protein-clip170-negatively-regulates-tlr4-signaling-by-targeting-the-tlr-adaptor-protein-tirap
#19
Padmaja Jakka, Bindu Bhargavi, Swapna Namani, Subathra Murugan, Gary Splitter, Girish Radhakrishnan
Cytoplasmic linker protein 170 (CLIP170) is a CAP-Gly domain-containing protein that is associated with the plus end of growing microtubules and implicated in various cellular processes, including the regulation of microtubule dynamics, cell migration, and intracellular transport. Our studies revealed a previously unrecognized property and role of CLIP170. We identified CLIP170 as one of the interacting partners of Brucella effector protein TcpB that negatively regulates TLR2 and TLR4 signaling. In this study, we demonstrate that CLIP170 interacts with the TLR2 and TLR4 adaptor protein TIRAP...
December 8, 2017: Journal of Immunology: Official Journal of the American Association of Immunologists
https://www.readbyqxmd.com/read/29222114/blood-vitronectin-is-a-major-activator-of-lif-and-il-6-in-the-brain-through-integrin-fak-and-upar-signaling
#20
M P Keasey, C Jia, L F Pimentel, R S Sante, C Lovins, T Hagg
We defined how blood-derived vitronectin (VTN) rapidly and potently activates leukemia inhibitory factor (LIF) and pro-inflammatory interleukin 6 (IL-6) in vitro and after vascular injury in the brain. VTN (not fibrinogen, fibronectin, laminin-111, collagen-I) robustly increased LIF and IL-6 within 4 hr in C6-astroglioma cells, while VTN-/- mouse plasma was less effective than wildtype. LIF and IL-6 were induced by intracerebral injection of rhVTN in mice, but less by intracerebral hemorrhage in VTN-/- than wildtype littermates...
December 8, 2017: Journal of Cell Science
keyword
keyword
55833
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"