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https://www.readbyqxmd.com/read/28549290/anti-inflammatory-potential-of-hentriacontane-in-lps-stimulated-raw-264-7-cells-and-mice-model
#1
Vidushi Khajuria, Shilpa Gupta, Neha Sharma, Ashok Kumar, Nazir A Lone, Mowkshi Khullar, Prabhu Dutt, Parduman Raj Sharma, Asha Bhagat, Zabeer Ahmed
Hentriacontane, has various pharmacological effects including anti-inflammatory, antitumor and antimicrobial activities. Its anti-inflammatory potential has been demonstrated in peritoneal macrophages. However detailed studies on other models elucidating the mechanistic description of the mode of action has not been done. Hence, the aim of the present study is to evaluate the anti-inflammatory potential of hentriacontane both in-vivo (Balb/c mice) and in-vitro (RAW 264.7 cells). Cytokine inhibition of both pro-inflammatory (TNF-α, IL-6, MCP-1 and IL-1β) and anti-inflammatory (IL-10) cytokines was studied in RAW 264...
May 23, 2017: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/28549109/il-18-cleavage-triggers-cardiac-inflammation-and-fibrosis-upon-%C3%AE-adrenergic-insult
#2
Han Xiao, Hao Li, Jing-Jing Wang, Jian-Shu Zhang, Jing Shen, Xiang-Bo An, Cong-Cong Zhang, Ji-Min Wu, Yao Song, Xin-Yu Wang, Hai-Yi Yu, Xiang-Ning Deng, Zi-Jian Li, Ming Xu, Zhi-Zhen Lu, Jie Du, Wei Gao, Ai-Hua Zhang, Yue Feng, You-Yi Zhang
Aims: Rapid over-activation of β-adrenergic receptor (β-AR) upon stress leads to cardiac inflammation, a prevailing factor that underlies heart injury. However, mechanisms by which acute β-AR stimulation induce cardiac inflammation still remain unknown. Here, we set out to identify the crucial role of inflammasome/interleukin (IL)-18 in initiating and maintaining cardiac inflammatory cascades upon β-AR insult. Methods and results: Male C57BL/6 mice were injected with a single dose of β-AR agonist, isoproterenol (ISO, 5 mg/kg body weight) or saline subcutaneously...
May 26, 2017: European Heart Journal
https://www.readbyqxmd.com/read/28549057/both-antenatal-and-postnatal-inflammation-contribute-information-about-the-risk-of-brain-damage-in-extremely-preterm-newborns
#3
Diana Yanni, Steven Korzeniewski, Elizabeth N Allred, Raina N Fichorova, T Michael O'Shea, Karl Kuban, Olaf Dammann, Alan Leviton
BACKGROUNDPreterm newborns exposed to intrauterine inflammation are at increased risk of neurodevelopmental disorders. We hypothesized that adverse outcomes are more strongly associated with a combination of antenatal and postnatal inflammation than with either of them alone.METHODSWe defined antenatal inflammation as histologic inflammation in the placenta. We measured the concentrations of seven inflammation-related proteins in blood obtained on postnatal days 1, 7, and 14 from 763 infants born before 28 weeks of gestation...
May 26, 2017: Pediatric Research
https://www.readbyqxmd.com/read/28549054/regulation-of-mir-146a-and-traf6-in-the-diagnose-of-lupus-nephritis
#4
Yunfeng Zhu, Zhenzhen Xue, Lizhe Di
BACKGROUND Lupus nephritis (LN) is a major complication of systemic lupus erythematosus (SLE). This study tested miR-146a and its target gene TRAF6 expression in LN patients and discussed their relationship with LN. MATERIAL AND METHODS One hundred twenty-eight LN patients and 30 healthy controls were enrolled in this study. MiR-146a and TRAF6 expression in peripheral blood mononuclear cells (PBMCs) were detected. Serum cytokines content was determined by ELISA. The diagnostic role of miR-146a and TRAF6 in LN activity was evaluated by ROC curve...
May 26, 2017: Medical Science Monitor: International Medical Journal of Experimental and Clinical Research
https://www.readbyqxmd.com/read/28548958/interleukin-6-174g-c-gene-promoter-polymorphism-and-prognosis-in-patients-with-cancer
#5
Kan Zhai, Yong Yang, Zhi-Gang Gao, Jie Ding
Interleukin-6 (IL-6) is known to be involved in the pathogenesis of cancer progression. IL-6-174G>C polymorphism has shown several results in association studies. In this study, we evaluated the association the IL-6-174G>C polymorphism and overall survival (OS) of cancer using 17 eligible studies with 4,304 patients. Our meta-analysis indicated that IL-6-174G>C polymorphism is not associated with OS when assessed using 3 genotype comparison including GG/(GC+CC), CC/(GC+GG) and CC/GG. Interestingly, compared to GG carrier, patients with IL-6-174GC genotype showed a decreased hazard of poor OS (hazard ratio = 0...
May 10, 2017: Oncotarget
https://www.readbyqxmd.com/read/28548891/immunological-characteristics-of-colitis-associated-with-anti-ctla-4-antibody-therapy
#6
Giorgos Bamias, Ioanna Delladetsima, Marina Perdiki, Spyros I Siakavellas, Dimitrios Goukos, George V Papatheodoridis, George L Daikos, Helen Gogas
Anti-CTL4-A therapy is associated with development of colitis. We characterized ipilimumab-associated colitis in nine melanoma patients (6 male, mean age: 55.3-yrs). Median value for diarrhea grade was 2, number of ipilimumab doses 2, and interval since last administration 3-wks. Endoscopic characteristics resembled inflammatory bowel disease and histology revealed predominance of plasmacytes or CD4+ T-cells. We observed significant upregulation of Th1 and Th17 effector pathways (>10-fold increase for IFN-γmRNA, >5-fold for IL-17A, p < 0...
May 26, 2017: Cancer Investigation
https://www.readbyqxmd.com/read/28548885/metformin-inhibits-p-gingivalis-lipopolysaccharide-lps-influenced-inflammatory-response-in-human-gingival-fibroblasts-via-regulating-activating-transcription-factor-3-atf3-expression
#7
Wenyan Kang, Ting Wang, Zhekai Hu, Feng Liu, Yundong Sun, Shaohua Ge
BACKGROUND: Chronic periodontitis is one of the most prevalent oral diseases, which is associated with Porphyromonas gingivalis (P. gingivalis) Lipopolysaccharide (LPS) infection, and has profound effects on type 2 diabetes mellitus (DM2). Metformin, a well-known antidiabetic agent, has been reported to exert anti-inflammatory effects on various cells. This study aimed to investigate the role of metformin on LPS-influenced inflammatory response in human gingival fibroblasts (HGFs). METHODS: Dose-dependent additive effects of metformin on LPS-influenced HGFs were detected...
May 26, 2017: Journal of Periodontology
https://www.readbyqxmd.com/read/28548297/dysregulation-of-the-causative-genes-for-hereditary-parkinsonism-in-the-midbrain-in-parkinson-s-disease
#8
Yun Joong Kim, Junbeom Jeon, Jaemoon Shin, Nan Young Kim, Jeong Hoon Hong, Jae-Min Oh, SangKyoon Hong, Yeo Jin Kim, Young-Eun Kim, Suk Yun Kang, Hyeo-Il Ma, Unjoo Lee, Jeehee Yoon
BACKGROUND AND OBJECTIVES: Many hereditary movement disorders with complex phenotypes without a locus symbol prefix for familial PD present as parkinsonism; however, the dysregulation of genes associated with these phenotypes in the SNpc of PD patients has not been systematically studied. METHODS: Gene set enrichment analyses were performed using 10 previously published genome-wide expression datasets obtained by laser-captured microdissection of pigmented neurons in the SNpc...
May 26, 2017: Movement Disorders: Official Journal of the Movement Disorder Society
https://www.readbyqxmd.com/read/28548090/synergistic-il-6-and-il-8-paracrine-signalling-pathway-infers-a-strategy-to-inhibit-tumour-cell-migration
#9
Hasini Jayatilaka, Pranay Tyle, Jonathan J Chen, Minsuk Kwak, Julia Ju, Hyun Ji Kim, Jerry S H Lee, Pei-Hsun Wu, Daniele M Gilkes, Rong Fan, Denis Wirtz
Following uncontrolled proliferation, a subset of primary tumour cells acquires additional traits/mutations to trigger phenotypic changes that enhance migration and are hypothesized to be the initiators of metastasis. This study reveals an adaptive mechanism that harnesses synergistic paracrine signalling via IL-6/8, which is amplified by cell proliferation and cell density, to directly promote cell migration. This effect occurs in metastatic human sarcoma and carcinoma cells- but not in normal or non-metastatic cancer cells-, and likely involves the downstream signalling of WASF3 and Arp2/3...
May 26, 2017: Nature Communications
https://www.readbyqxmd.com/read/28547815/balancing-the-autonomic-nervous-system-to-reduce-inflammation-in-rheumatoid-arthritis
#10
F A Koopman, M A van Maanen, M J Vervoordeldonk, P P Tak
Imbalance in the autonomic nervous system (ANS) has been observed in many established chronic autoimmune diseases, including rheumatoid arthritis (RA), which is a prototypic immune-mediated inflammatory disease (IMID). We recently discovered that autonomic dysfunction precedes and predicts arthritis development in subjects at risk of developing seropositive RA. In addition, RA patients with relatively high vagus nerve tone (higher parasympathetic parameters, measured by heart rate variability) respond better to antirheumatic therapies...
May 26, 2017: Journal of Internal Medicine
https://www.readbyqxmd.com/read/28547808/cytokine-response-in-crimean-congo-hemorrhagic-fever-virus-infection
#11
Önder Ergönül, Ceren Şeref, Şebnem Eren, Aysel Çelikbaş, Nurcan Baykam, Başak Dokuzoğuz, Mehmet Gönen, Füsun Can
BACKGROUND: We described the predictive role of cytokines in fatality of Crimean Congo Hemorrhagic Fever Virus (CCHFV) infection by using daily clinical sera samples. METHODS: Consequent serum samples of the selected patients in different severity groups and healthy controls were examined by using human cytokine 17-plex assay. RESULTS: We included 12(23%) mild, 30(58%) moderate, 10(19%) severe patients, and 10 healthy volunteers. The mean age of the patients was 52 (sd 15), 52% were female...
May 26, 2017: Journal of Medical Virology
https://www.readbyqxmd.com/read/28547750/management-of-long-term-therapy-with-biological-drugs-in-psoriatic-patients-with-latent-tuberculosis-infection-in-real-life-setting
#12
Andrea Conti, Stefano Piaserico, Paolo Gisondi, Giulia Odorici, Giovanna Galdo, Claudia Lasagni, Giovanni Pellacani
Psoriatic patients with latent tuberculosis infection (LTBI) need a prophylaxis before starting a treatment with biological drugs. The aim of this study is to investigate the safety and efficacy of prophylaxis of LTBI in psoriatic patients receiving long-term biological drugs. The study included 56 patients (42 male and 14 female) affected by moderate-to-severe psoriasis (mean PASI: 12.8 ± 6.9 SD) treated with anti-TNF-α and/or anti IL 12, 23 and/or anti-CD11 drugs with a diagnosis of LTBI. LTBI diagnosis was based on tuberculin skin test and/or QuantiFERON TB Gold test positivity and chest X-ray suggestive, without clinical, or microbiological evidence of active disease...
May 26, 2017: Dermatologic Therapy
https://www.readbyqxmd.com/read/28547701/terminalia-arjuna-prevents-interleukin-18-induced-atherosclerosis-via-modulation-of-nf-%C3%AE%C2%BAb-ppar-%C3%AE-mediated-pathway-in-apo-e-mice
#13
Owais Mohammad Bhat, P Uday Kumar, K Rajender Rao, Ashfaq Ahmad, Veena Dhawan
AIM OF THE STUDY: Terminalia arjuna is a medicinal plant well known as a cardiotonic in Ayurvedic system of medicine. We hypothesized that aqueous stem bark extract of T. arjuna (TAE) may inhibit IL-18-induced atherosclerosis via NF-κB/PPAR-γ-mediated pathway in Apo E-/- mice. MATERIALS AND METHODS: 12-week-old, male Apo E-/- mice divided into four groups (n = 6/group) fed with normal chow-diet were employed: GP I: phosphate buffer saline (PBS) (2 month); GP II: rIL-18 (1 month) followed by PBS (1 month); GP III: rIL-18 (1 month) followed by TAE (1 month); GP IV: rIL-18 (1 month) followed by atorvastatin (1 month)...
May 25, 2017: Inflammopharmacology
https://www.readbyqxmd.com/read/28547650/lysosomal-destabilization-activates-the-nlrp3-inflammasome-in-human-umbilical-vein-endothelial-cells-huvecs
#14
K Kinnunen, N Piippo, S Loukovaara, M Hytti, K Kaarniranta, A Kauppinen
Inflammation is a crucial component in the pathogenesis of many vascular diseases, such as atherosclerosis and diabetes. Inflammasomes are intracellular signalling complexes whose activation promotes inflammation. Nucleotide-binding domain and Leucine-rich repeat Receptor containing a Pyrin domain 3 (NLRP3) is a pattern recognition receptor (PRR) forming the best-known inflammasome. Disturbances in NLRP3 have been associated with multiple diseases. The purpose of this study was to explore the lysosomal destabilization-related NLRP3 inflammasome signaling pathway in human endothelial cells...
May 25, 2017: Journal of Cell Communication and Signaling
https://www.readbyqxmd.com/read/28547592/impact-of-interim-progression-during-the-surgery-to-radiotherapy-interval-and-its-predictors-in-glioblastoma-treated-with-temozolomide-based-radiochemotherapy
#15
Chan Woo Wee, Eunji Kim, Tae Min Kim, Chul-Kee Park, Jin Wook Kim, Seung Hong Choi, Roh-Eul Yoo, Soon-Tae Lee, Il Han Kim
This study was designed to investigate the impact of interim progression of disease (PD) during the surgery-to-radiotherapy interval (SRI) and its predictors in glioblastoma based on MRIs. A total of 222 patients were planned for radiotherapy (RT) and 166 of them were evaluable for the presence of interim PD by 2 separate MRIs. The size criteria from the updated Response Assessment in Neuro-Oncology criteria was adopted to determine interim PD. 32 (19.3%) patients experienced interim PD, and their median survival (MS) was shorter than patients without PD in univariate (11...
May 25, 2017: Journal of Neuro-oncology
https://www.readbyqxmd.com/read/28547566/incidence-and-predictors-of-hypoglycemia-1-year-after-laparoscopic-sleeve-gastrectomy
#16
Anna Belligoli, Marta Sanna, Roberto Serra, Roberto Fabris, Chiara Dal Pra', Scilla Conci, Paola Fioretto, Luca Prevedello, Mirto Foletto, Roberto Vettor, Luca Busetto
INTRODUCTION: Hypoglycemia is a known adverse event following gastric bypass. The incidence of hypoglycemia after laparoscopic sleeve gastrectomy (LSG) is still under investigation. The aim of our study was to verify the presence of oral glucose tolerance test (OGTT)-related hypoglycemia after LSG and to identify any baseline predictors of its occurrence. METHODS: We analyzed 197 consecutive non-diabetic morbid obese patients that underwent LSG. All patients were studied before and 12 months after LSG...
May 25, 2017: Obesity Surgery
https://www.readbyqxmd.com/read/28547123/anethole-reduces-inflammation-and-joint-damage-in-rats-with-adjuvant-induced-arthritis
#17
Alessandra Mileni Versuti Ritter, Luzmarina Hernandes, Bruno Ambrosio da Rocha, Camila Fernanda Estevão-Silva, Edirlene Sara Wisniewski-Rebecca, Joice Dos Santos Cezar, Silvana Martins Caparroz-Assef, Roberto Kenji Nakamura Cuman, Ciomar Aparecida Bersani-Amado
AIM: This study evaluated whether anethole attenuates the inflammatory response and joint damage in a model of adjuvant-induced arthritis (AIA) in rats. METHODS: The animals were treated with 62.5-, 125-, or 250-mg/kg anethole daily for 21 days after AIA and necropsied on days 14 and 21 to evaluate the number of serum and synovial leukocytes (total and differential), serum cytokines (IL-2, IL-6, IL-12, IL-17, and TNF-α), and nitric oxide concentrations. Morphologic changes in the cartilage and bone of the femorotibial articulation in both left paw and right paw were studied in hematoxylin/eosin and Sirius Red-hematoxylin sections...
May 25, 2017: Inflammation Research: Official Journal of the European Histamine Research Society ... [et Al.]
https://www.readbyqxmd.com/read/28546929/aqueous-proinflammatory-cytokines-in-acute-primary-angle-closure-eyes
#18
Yao-Ming Liu, Shi-Da Chen, Xing-Yi Li, Wen-Bin Huang, Fei Li, Jia-Wei Wang, Ying-Qi Li, Xiu-Lan Zhang
AIM: To evaluate changes of proinflammatory cytokines in aqueous humor of patients with acute primary angle-closure (APAC) and age-related cataracts. METHODS: Twenty eyes of 20 APAC patients and 15 eyes of 15 age-related cataract patients were included in this cross-sectional study. Aqueous humor samples were collected prospectively. The levels of 20 proinflammatory cytokines were evaluated in the aqueous humor of the APAC and cataract patients using the multiplex bead immunoassay technique...
2017: International Journal of Ophthalmology
https://www.readbyqxmd.com/read/28546541/protective-effect-of-low-dose-intra-articular-cadmium-on-inflammation-and-joint-destruction-in-arthritis
#19
Paola Bonaventura, Guillaume Courbon, Aline Lamboux, Fabien Lavocat, Hubert Marotte, Francis Albarède, Pierre Miossec
Synovium hyperplasia characterizes joint diseases, such as rheumatoid arthritis (RA). The cytotoxic effect of low-dose Cadmium (Cd) was tested in vitro and ex vivo on synoviocytes, the mesenchymal key effector cells of inflammation and proliferation in arthritis. The anti-inflammatory and anti-proliferative effects of Cd were tested in vivo by intra-articular injection in the adjuvant induced arthritis rat joints, where the clinical scores and the consequences of arthritis were evaluated. Cell death through apoptosis was highly induced by Cd in inflammatory synoviocytes (80% reduction of cell viability, p < 0...
May 25, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28546502/can-we-design-a-better-anti-cytokine-therapy
#20
Marina S Drutskaya, Grigory A Efimov, Andrei A Kruglov, Sergei A Nedospasov
Cytokine neutralization is successfully used for treatment of various autoimmune diseases and chronic inflammatory conditions. The complex biology of the two well-characterized proinflammatory cytokines TNF and IL-6 implicates unavoidable consequences when it comes to their global blockade. Because systemic cytokine ablation may result in unwanted side effects, efforts have been made to develop more specific cytokine inhibitors, which would spare the protective immunoregulatory functions of a given cytokine...
May 25, 2017: Journal of Leukocyte Biology
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