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https://www.readbyqxmd.com/read/29036956/-the-diagnostic-value-of-neuron-specific-enolase-central-nervous-system-specific-protein-and-interleukin-6-in-sepsis-associated-encephalopathy
#1
Q Feng, L Wu, Y H Ai, S Y Deng, M L Ai, L Huang, Z Y Liu, L N Zhang
Objective: To investigate the diagnostic value of neuron-specific enolase(NSE), central nervous system specific protein(S100β), interleukin-6(IL-6) in sepsis-associated encephalopathy(SAE). Methods: Clinical data of patients admitted to ICU and diagnosed with sepsis were collected from January 2015 to June 2016 in Xiangya Hospital, Central South University. SAE was defined as cerebral dysfunction in the presence of sepsis that also fulfilled the exclusion criteria. The acute physiology and chronic health score (APACHE Ⅱ), sequential organ failure assessment (SOFA), NSE, S100β, IL-6, ICU stay time and 28-day mortality were compared between the two groups...
October 1, 2017: Zhonghua Nei Ke za Zhi [Chinese Journal of Internal Medicine]
https://www.readbyqxmd.com/read/29036927/chinese-olive-canarium-album-l-fruit-extract-attenuates-metabolic-dysfunction-in-diabetic-rats
#2
Yu-Te Yeh, An-Na Chiang, Shu-Chen Hsieh
Hyperglycemia and dysregulation of lipid metabolism play a crucial role in metabolic dysfunction. The aims of present study were to evaluate the ameliorative effect of the ethyl acetate fraction of Chinese olive fruit extract (CO-EtOAc) on high-fat diet (HFD) and streptozotocin (STZ)-induced diabetic rats. CO-EtOAc, rich in gallic acid and ellagic acid, could markedly decreased the body weight and epididymal adipose mass. In addition, CO-EtOAc increased serum HDL-C levels, hepatic GSH levels, and antioxidant enzyme activities; lowered blood glucose, serum levels of total cholesterol (TC), triglycerides (TG), bile acid, and tumor necrosis factor alpha (TNFα); and reduced TC and TG in liver...
October 15, 2017: Nutrients
https://www.readbyqxmd.com/read/29036910/melatonin-treatment-reduces-oxidative-damage-and-normalizes-plasma-pro-inflammatory-cytokines-in-patients-suffering-from-charcot-marie-tooth-neuropathy-a-pilot-study-in-three-children
#3
Mariam Chahbouni, María Del Señor López, Antonio Molina-Carballo, Tomás de Haro, Antonio Muñoz-Hoyos, Marisol Fernández-Ortiz, Ana Guerra-Librero, Darío Acuña-Castroviejo
Charcot-Marie-Tooth neuropathy (CMT) is a motor and sensory neuropathy comprising a heterogeneous group of inherited diseases. The CMT1A phenotype is predominant in the 70% of CMT patients, with nerve conduction velocity reduction and hypertrophic demyelination. These patients have elevated oxidative stress and chronic inflammation. Currently, there is no effective cure for CMT; herein, we investigated whether melatonin treatment may reduce the inflammatory and oxidative damage in CMT1A patients. Three patients, aged 8-10 years, were treated with melatonin (60 mg at 21:00 h plus 10 mg at 09:00 h), and plasma levels of lipid peroxidation (LPO), nitrites (NOx), IL-1β, IL-2, IL-6, TNF-α, INF-γ, oxidized to reduced glutathione (GSSG/GSH) ratio, and the activities of superoxide dismutase (SOD), glutathione-S transferase (GST), glutathione peroxidase (GPx), and reductase (GRd), were determined in erythrocytes at 3 and 6 months of treatment...
October 14, 2017: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
https://www.readbyqxmd.com/read/29036854/functional-repertoire-of-interleukin-6-in-the-central-nervous-system-a-review
#4
Klaus Heese
In an aging society with dementia imposing an increasing threat to higher brain cognitive functions, understanding the molecular and cellular events of adult neurogenesis is imperative. Interleukin-6 (IL-6), along with its agonistic acting soluble receptor sIL-6R (the combined proteins are also known as Hyper-IL-6), is a promising cytokine that can support neurogenesis under conditions of neurodegeneration when neuron replacement is needed. In contrast to the previously reported gliogenic effects of activation of the IL-6-signal transducer and activator of transcription 3 (STAT3) axis, this review summarizes recent studies showing that IL-6 activation can be neurogenic and has potential therapeutic applications for the treatment of neurodegenerative diseases such as Parkinson's disease...
October 9, 2017: Restorative Neurology and Neuroscience
https://www.readbyqxmd.com/read/29036520/lung-specific-overexpression-of-constitutively-active-ikk2-induces-pulmonary-and-systemic-inflammations-but-not-hypothalamic-inflammation-and-glucose-intolerance
#5
Minjie Chen, Huifen Zhou, Yanyi Xu, Lianglin Qiu, Ziying Hu, Xiaobo Qin, Sufang Chen, Yuhao Zhang, Qi Cao, Yousef Abu-Amer, Zhekang Ying
The lung is constantly exposed to ambient pollutants such as ambient fine particulate matter (PM2.5), making it one of the most frequent locations of inflammation in the body. Given the establishment of crucial role of inflammation in the pathogenesis of cardiometabolic diseases, pulmonary inflammation is thus widely believed to be an important risk factor for cardiometabolic diseases. However, the causality between them has not yet been well established. To determine if pulmonary inflammation is sufficient to cause adverse cardiometabolic effects, SFTPC-rtTA+/-tetO-cre+/-pROSA-inhibitor κB kinase 2(IKK2)ca+/- (LungIKK2ca) and littermate SFTPC-rtTA+/-tetO-cre-/-pROSA-IKK2ca+/- wildtype (WT) mice were fed with doxycycline diet to induce constitutively active Ikk2 (Ikk2ca) overexpression in the lung and their pulmonary, systemic, adipose, and hypothalamic inflammations, vascular function, and glucose homeostasis were assessed...
July 28, 2017: Toxicological Sciences: An Official Journal of the Society of Toxicology
https://www.readbyqxmd.com/read/29036458/metabolic-syndrome-induces-over-expression-of-the-human-at1r-a-haplotype-dependent-effect-with-implications-on-cardio-renal-function
#6
Sudhir Jain, Nitin Puri, Anita Rana, Natalie Sirianni, Brahmaraju Mopidevi, Ashok Kumar
Background: The transcriptional regulation of the human AT1R gene in pathophysiologies, like the metabolic syndrome, is poorly understood. The human AT1R gene has polymorphisms in its promoter that can be arranged in two haplotypes. Variants -810T, -713T, -214A, and -153A always occur together (Hap-I) and variants -810A, -713G, -214C, and -153G form Hap-II. We have hypothesized that high fat diet will alter cellular transcriptional milieu and increase hAT1R gene expression in a haplotype-dependent manner...
October 5, 2017: American Journal of Hypertension
https://www.readbyqxmd.com/read/29036448/il6-secretion-from-alternatively-activated-macrophages-promotes-the-migration-of-endometriotic-epithelial-cells
#7
Jeong-Hwa Woo, Yeong-In Yang, Ji-Hye Ahn, Youn Seok Choi, Jung-Hye Choi
Accumulating evidence has suggested an interaction between endometriotic cells and macrophages in the endometriotic microenvironment and the potential role of this interaction in the pathogenesis of endometriosis. However, how endometriotic cells communicate with macrophages to influence their function is poorly understood. In the present study, we found that the mRNA expression and production of CC chemokine ligand 2 (CCL2) were much higher in human endometriotic epithelial cells (11Z and 12Z) than those in human endometrial epithelial cells (HES)...
October 4, 2017: Biology of Reproduction
https://www.readbyqxmd.com/read/29036223/evaluation-of-blood-brain-barrier-function-by-quotient-alpha2-macroglobulin-and-its-relationship-with-interleukin-6-and-complement-component-3-levels-in-neuropsychiatric-systemic-lupus-erythematosus
#8
Tomoyuki Asano, Hiromi Ito, Yoshinobu Kariya, Kyoka Hoshi, Akioh Yoshihara, Yoshikazu Ugawa, Hideharu Sekine, Shunsei Hirohata, Yoshiki Yamaguchi, Shuzo Sato, Hiroko Kobayashi, Kiyoshi Migita, Hiromasa Ohira, Yasuhiro Hashimoto, Hiroshi Watanabe
Although quotient of alpha2 macroglobulin (Qα2MG) was previously reported to be useful for the evaluation of blood-brain barrier (BBB) function, it is not commonly used. We therefore evaluated BBB function among the various subsets of neuropsychiatric systemic lupus erythematosus (NPSLE) using quotient Q α2MG. Furthermore, we determined the correlation between Q α2MG and cerebrospinal (CSF) interleukin (IL)-6 level and quotient complement component 3 (Q C3). To determine intrathecal production of C3, the C3 index (Q C3/Q α2MG) was also calculated...
2017: PloS One
https://www.readbyqxmd.com/read/29036211/orally-administered-taenia-solium-calreticulin-prevents-experimental-intestinal-inflammation-and-is-associated-with-a-type-2-immune-response
#9
Fela Mendlovic, Mayra Cruz-Rivera, Jose Alfredo Diaz-Gandarilla, Marco Antonio Flores-Torres, Guillermina Avila, Maria Perfiliev, Ana Maria Salazar, Lourdes Arriaga-Pizano, Patricia Ostrosky-Wegman, Ana Flisser
Intestinal helminth antigens are inducers of type 2 responses and can elicit regulatory immune responses, resulting in dampened inflammation. Several platyhelminth proteins with anti-inflammatory activity have been reported. We have identified, cloned and expressed the Taenia solium calreticulin (rTsCRT) and shown that it predominantly induces a type 2 response characterized by IgG1, IL-4 and IL-5 production in mice. Here, we report the rTsCRT anti-inflammatory activity in a well-known experimental colitis murine model...
2017: PloS One
https://www.readbyqxmd.com/read/29036184/proinflammatory-response-of-canine-trophoblasts-to-brucella-canis-infection
#10
Andrea G Fernández, M Soledad Hielpos, Mariana C Ferrero, Carlos A Fossati, Pablo C Baldi
Brucella canis infection is an important cause of late-term abortion in pregnant bitches. The pathophysiological mechanisms leading to B. canis-induced abortion are unknown, but heavily infected trophoblasts are consistently observed. As trophoblasts responses to other pathogens contribute to placental inflammation leading to abortion, the aim of the present study was to characterize the cytokine response of canine trophoblasts to B. canis infection. To achieve this, trophoblasts isolated from term placenta of healthy female dogs were infected with B...
2017: PloS One
https://www.readbyqxmd.com/read/29035818/skin-penetrating-polymeric-nanoparticles-incorporated-in-silk-fibroin-hydrogel-for-topical-delivery-of-curcumin-to-improve-its-therapeutic-effect-on-psoriasis-mouse-model
#11
Kai-Li Mao, Zi-Liang Fan, Jian-Dong Yuan, Pian-Pian Chen, Jing-Jing Yang, Jie Xu, De-Li ZhuGe, Bing-Hui Jin, Qun-Yan Zhu, Bi-Xin Shen, Yasin Sohawon, Ying-Zheng Zhao, He-Lin Xu
A poor percutaneous penetration capability for most topical anti-inflammatory drugs is one of the main causes compromising their therapeutic effects on psoriatic skin. Even though curcumin has shown a remarkable efficacy in the treatment of psoriasis, its effective penetration through the stratum corneum is still a major challenge during transdermal delivery. The aim of our study was to design skin-permeating nanoparticles (NPs) to facilitate delivery of curcumin to the deeper layers of the skin. A novel amphiphilic polymer, RRR-α-tocopheryl succinate-grafted-ε-polylysine conjugate (VES-g-ε-PLL) was synthesized and self-assembled into polymeric nanoparticles...
October 10, 2017: Colloids and Surfaces. B, Biointerfaces
https://www.readbyqxmd.com/read/29035816/docosahexaenoic-acid-attenuates-carbon-tetrachloride-induced-hepatic-fibrosis-in-rats
#12
Jianlin He, Kaikai Bai, Bihong Hong, Feng Zhang, Shizhong Zheng
Fish oil containing docosahexaenoic acid (DHA) and eicosapentaenoic acid (EPA) has been reported to exert beneficial health effects, including hepatoprotection. However, the effect of DHA alone has not been well studied, and the mechanism is not fully understood. In the present study, we reported the protective effect of DHA on carbon tetrachloride (CCl4) induced hepatic fibrosis. Compared with the control group, the CCl4 group showed hepatic damage as evidenced by histological changes and elevation in serum transaminase activity, fibrosis, inflammation and oxidative stress levels...
October 13, 2017: International Immunopharmacology
https://www.readbyqxmd.com/read/29035597/influence-of-2-weeks-ingestion-of-high-chlorogenic-acid-coffee-on-mood-state-performance-and-post-exercise-inflammation-and-oxidative-stress-a-randomized-placebo-controlled-trial
#13
David C Nieman, Courtney L Goodman, Christopher R Capps, Zack L Shue, Robert Arnot
This study measured the influence of 2-weeks ingestion of high chlorogenic acid (CQA) coffee on post-exercise inflammation and oxidative stress, with secondary outcomes including performance and mood state. Cyclists (N=15) were randomized to CQA coffee or placebo (300 ml/day) for 2 weeks, participated in a 50-km cycling time trial, and then crossed over to the opposite condition with a 2-week washout period. Blood samples were collected pre- and post-supplementation, and immediately post-exercise. CQA coffee was prepared using the Turkish method with 30 g lightly roasted, highly ground Hambela coffee beans in 300 ml boiling water, and provided 1,066 mg CQA and 474 mg caffeine versus 187 mg CQA and 33 mg caffeine for placebo...
October 16, 2017: International Journal of Sport Nutrition and Exercise Metabolism
https://www.readbyqxmd.com/read/29035456/circulating-mir-29b-and-mir-424-as-prognostic-markers-in-patients-with-acute-cerebral-infarction
#14
Yue-Zhan Zhang, Jun Wang, Feng Xu
BACKGROUND: Down-regulation of miR-29b and miR-424 have been observed in patients with acute cerebral infarction (ACI); however, the clinical significance of circulating miR-29b and miR-424 as prognostic markers still requires further investigation. METHODS: A total of 45 patients diagnosed with ACI and 45 healthy volunteers were enrolled in this study, and the clinical information of the patients were collected. The serum samples of the participants were collected and stored at -80°C...
October 1, 2017: Clinical Laboratory
https://www.readbyqxmd.com/read/29035328/pterodontic-acid-isolated-from-laggera-pterodonta-inhibits-viral-replication-and-inflammation-induced-by-influenza-a-virus
#15
Wenda Guan, Jing Li, Qiaolian Chen, Zhihong Jiang, Rongping Zhang, Xinhua Wang, Zifeng Yang, Xiping Pan
Laggera pterodonta (DC.) Benth. is a traditional Chinese medicine. The previous study revealed that the crude extracts of this herb could inhibit influenza virus infection, but its anti-influenza components and underlying mechanism of action remain unknown. Column chromatography was performed to isolate components from the plant. Activity against influenza virus of the compound was determined by CPE inhibition assay. Neuraminidase (NA) inhibition was measured by chemiluminescence assay. The anti-virus and anti-inflammation effects were determined using dual-luciferase reporter assay, immunofluorescence, quantitative real-time PCR and luminex assay...
October 16, 2017: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
https://www.readbyqxmd.com/read/29035099/association-between-growth-differentiation-factor-15-and-left-ventricular-hypertrophy-in-hypertensive-patients-and-healthy-adults
#16
Huijuan Kou, Xin Jin, Dengfeng Gao, Rui Ma, Xin Dong, Jin Wei, Xin Wang
Growth differentiation factor 15 (GDF-15) as an independent biomarker of cardiovascular diseases merits further evaluation. We studied the association between plasma GDF-15 levels and left ventricular hypertrophy (LVH) in hypertensive patients and healthy adults. Hypertensive LVH measurements were performed via echocardiography and analyzed using the cube formula, and human GDF-15 together with interleukin-6 (IL-6) and matrix metalloproteinase-9 (MMP-9) concentrations were determined via enzyme-linked immunosorbent assay (ELISA)...
October 16, 2017: Clinical and Experimental Hypertension: CHE
https://www.readbyqxmd.com/read/29034996/interleukin-1%C3%AE-polymorphism-and-serum-level-are-associated-with-pediatric-asthma
#17
Paulina Sobkowiak, Irena Wojsyk-Banaszak, Maja Kowalewska, Eliza Wasilewska, Wojciech Langwiński, Zdzisława Kycler, Maria Skibińska, Anna Bręborowicz, Ewa Jassem, Aleksandra Szczepankiewicz
BACKGROUND AND AIM: Interleukin-1 is a pro-inflammatory cytokine found in two forms (α and β). The α form is mainly cell-bound, whereas IL-1β is primarily secreted by macrophages in response to immune system stimulation. We hypothesized that polymorphic variants of interleukin 1 genes may play a role in childhood asthma risk. The aim of this study was to investigate if IL-1α and β polymorphism is associated with asthma in a pediatric population and if the genotype affects its serum level...
October 16, 2017: Pediatric Pulmonology
https://www.readbyqxmd.com/read/29034874/pathogenesis-of-plasmodium-berghei-anka-infection-in-the-gerbil-meriones-unguiculatus-as-an-experimental-model-for-severe-malaria
#18
Quazim Olawale Junaid, Loke Tim Khaw, Rohela Mahmud, Kien Chai Ong, Yee Ling Lau, Prajakta Uttam Borade, Jonathan Wee Kent Liew, Sinnadurai Sivanandam, Kum Thong Wong, Indra Vythilingam
BACKGROUND: As the quest to eradicate malaria continues, there remains a need to gain further understanding of the disease, particularly with regard to pathogenesis. This is facilitated, apart from in vitro and clinical studies, mainly via in vivo mouse model studies. However, there are few studies that have used gerbils (Meriones unguiculatus) as animal models. Thus, this study is aimed at characterizing the effects of Plasmodium berghei ANKA (PbA) infection in gerbils, as well as the underlying pathogenesis...
2017: Parasite: Journal de la Société Française de Parasitologie
https://www.readbyqxmd.com/read/29034589/involvement-of-local-renin-angiotensin-system-in-immunosuppression-of-tumor-microenvironment
#19
Kenta Nakamura, Tomonori Yaguchi, Gaku Ohmura, Asuka Kobayashi, Naoshi Kawamura, Takashi Iwata, Yukiko Kiniwa, Ryuhei Okuyama, Yutaka Kawakami
To improve the current cancer immunotherapies, strategies to modulate various immunosuppressive cells including myeloid derived suppressor cells (MDSCs) which were shown to be negative factors in the immune-checkpoint blockade therapy, need to be developed. In this study, we have evaluated the role of local renin-angiotensin system (RAS) in the tumor immune-microenvironment using murine models bearing tumor cell lines in which RAS was not involved in their proliferation and angiogenetic ability. Administration of angiotensin II receptor blockers (ARBs) to C57BL/6 mice bearing murine colon cancer cell line MC38 resulted in significant enhancement of tumor antigen gp70 specific T cells...
October 16, 2017: Cancer Science
https://www.readbyqxmd.com/read/29034441/the-oral-pretreatment-of-glycyrrhizin-prevents-surgery-induced-cognitive-impairment-in-aged-mice-by-reducing-neuroinflammation-and-alzheimer-s-related-pathology-via-hmgb1-inhibition
#20
Zhong-Hong Kong, Xin Chen, Hui-Po Hua, Liang Liang, Long-Juan Liu
Neuroinflammation and Alzheimer's-related pathology play essential roles in postoperative cognitive dysfunction (POCD). High-mobility group box 1 (HMGB1) is well known as a pivotal mediator in neuroinflammation, and its associations with Alzheimer's-related pathology and POCD have been also revealed. Glycyrrhizin is a nature inhibitor of HMGB1 and is reported with neuroprotective effects through oral administration. Therefore, the present study aims to test the hypothesis that the oral pretreatment of glycyrrhizin prevents POCD by inhibiting HMGB1-induced neuroinflammation and Alzheimer's-related pathology in aged mice...
October 16, 2017: Journal of Molecular Neuroscience: MN
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