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Caustic injuries

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https://www.readbyqxmd.com/read/29892928/halofuginone-improves-caustic-induced-oxidative-injury-of-esophagus-in-rats
#1
Kıvılcım Karadeniz Cerit, Berna Karakoyun, Elif Bahadır, Meral Yüksel, Nurdan Bülbül, Feriha Ercan, E Tolga Dağlı, Berrak Ç Yeğen
BACKGROUND: The aim of this study is to evaluate the anti-inflammatory and anti-fibrotic effects of halofuginone in caustic esophageal burn injury in rats. MATERIALS AND METHODS: Corrosive esophageal injury (CEI) was produced in male Wistar albino rats by instilling NaOH solution (1 ml, 37.5%) into the distal esophagus. Rats were decapitated on the 3rd day (early group) or 28th day (late group), and treated daily with either saline or halofuginone (100 µg/kg/day; i...
April 2018: Esophagus: Official Journal of the Japan Esophageal Society
https://www.readbyqxmd.com/read/29889306/ph-neutralizing-esophageal-irrigations-as-a-novel-mitigation-strategy-for-button-battery-injury
#2
Rachel R Anfang, Kris R Jatana, Rebecca L Linn, Keith Rhoades, Jared Fry, Ian N Jacobs
OBJECTIVES/HYPOTHESIS: Ingestion of button batteries (BB) can rapidly lead to caustic esophageal injury in infants and children, resulting in significant morbidity and mortality. To identify novel mitigation strategies, we tested common weakly acidic household beverages, viscous liquids, and Carafate® for their ability to act as protective esophageal irrigations until endoscopic removal of the BB. STUDY DESIGN: Cadaveric and live animal model. METHODS: Apple juice, orange juice, Gatorade®, POWERADE®, pure honey, pure maple syrup, and Carafate® were screened using a 3 V lithium (3 V-CR2032) BB on cadaveric porcine esophagus...
June 11, 2018: Laryngoscope
https://www.readbyqxmd.com/read/29859991/early-assessment-of-burn-severity-in-human-tissue-ex-vivo-with-multi-wavelength-spatial-frequency-domain-imaging
#3
Chien Poon, Ulas Sunar, Daniel J Rohrbach, Smita Krishnamurthy, Thomas Olsen, Michael Kent, Nathan M Weir, Richard Simman, Jeffrey B Travers
Early knowledge about burn severity and depth can lead to improved outcome for patients. In this study, we investigated the change in optical properties in ex vivo human skin following thermal burn injuries. Human skin removed during body contouring procedures was subjected to thermal burn injury for either 10 or 60 s. Multi-wavelength spatial frequency domain imaging (SFDI) measurements were performed on each sample and the optical properties (absorption and scattering parameters) were obtained at each wavelength...
May 31, 2018: Toxicology in Vitro: An International Journal Published in Association with BIBRA
https://www.readbyqxmd.com/read/29761251/correlation-of-99mtc-sucralfate-scan-and-endoscopic-grading-in-caustic-oesophageal-injury
#4
Babalwa B Nondela, Sharon G Cox, Anita Brink, Alastair J W Millar, Alp Numanoglu
PURPOSE: To determine a correlation between the 99mTc sucralfate scan and the endoscopy findings in children with caustic oesophageal injury. METHODS: This is an observational analytic study of children who had both 99mTc sucralfate scan and endoscopy after caustic substance ingestion at our institution in a period between January 2009 and September 2016. The oesophageal injury was classified into low grade and high grade according to the degree of adhesion on 99mTc sucralfate scan and modification of Zargar endoscopic grading...
May 14, 2018: Pediatric Surgery International
https://www.readbyqxmd.com/read/29682245/caustic-ingestion-in-children-in-south-of-iran-a-two-year-single-center-study
#5
Seyed Mohsen Dehghani, Maryam Bahmanyar, Hazhir Javaherizadeh
BACKGROUND Caustic ingestion is one of the most important injuries during childhood, which leads to serious sequel. In this study, we evaluated the clinical manifestations, endoscopic appearance, complications, and treatment results in patients with caustic ingestion in our hospital. METHODS Hospital chart of patients with caustic ingestion who admitted to Nemazee Teaching Hospital affiliated to Shiraz University of Medical Sciences during a 2-year period (2015-2016) were reviewed retrospectively. The age, sex, nature of the caustic agent, clinical presentations, grade of injury in endoscopy, degree of parents' education, site of ingestion, accidental or intentional attempts, complications, and outcomes were reviewed...
January 2018: Middle East Journal of Digestive Diseases
https://www.readbyqxmd.com/read/29533267/emergency-computed-tomography-predicts-caustic-esophageal-stricture-formation
#6
Matthieu Bruzzi, Mircea Chirica, Matthieu Resche-Rigon, Helene Corte, Thibault Voron, Emile Sarfati, Anne-Marie Zagdanski, Pierre Cattan
BACKGROUND: Endoscopy is the best predictor of stricture formation after caustic ingestion. OBJECTIVE: Our aim was to compare the accuracy of emergency computed tomography (CT) and endoscopy in predicting risks of esophageal stricture. METHODS: We describe a CT classification of esophageal caustic injuries: Grade I show normal esophagus; Grade IIa display internal enhancement of the esophageal mucosa and enhancement of the outer wall conferring a "target" aspect; Grade IIb present as a fine rim of external esophageal wall enhancement...
March 12, 2018: Annals of Surgery
https://www.readbyqxmd.com/read/29527559/eus-guided-gastroenterostomy-in-management-of-benign-gastric-outlet-obstruction
#7
Yen-I Chen, Theodore James, Amol Agarwal, Todd H Baron, Takao Itoi, Rastislav Kunda, Jose Nieto, Majidah Bukhari, Olaya Brewer Gutierrez, Omid Sanaei, Robert Moran, Lea Fayad, Mouen A Khashab
Background and study aims:  Endoscopic ultrasound-guided gastroenterostomy (EUS-GE) in malignant gastric outlet obstruction (GOO) appears to be promising; however, its role in benign GOO is unclear. The aim of this study was to ascertain the clinical efficacy and safety of EUS-GE in benign GOO. Patients and methods : This was an international retrospective series involving 5 tertiary centers. Consecutive patients who underwent EUS-GE between 1/2013 - 10/2016 for benign GOO were included...
March 2018: Endoscopy International Open
https://www.readbyqxmd.com/read/29489543/complex-intraoral-reconstruction-using-a-single-free-anterolateral-thigh-flap-and-supermicrosurgery-after-corrosive-ingestion-in-a-14-month-old-child
#8
Mohammed H El Fahar
Oral chemical burn injuries induce more damage to the underlying tissues with extensive scarring. It is very well known that alkali causes severe liquefaction necrosis and injury to the deeper tissues. Pediatric facial burns must be managed thoroughly and always require complex reconstruction, which is a challenging process. So, any reconstructive surgeon must be aware of all the deformities that may have significant functional and aesthetic impact on the burn survivors especially children. Few medical studies addressed pediatric microsurgical reconstruction for oral burn injuries induced by chemical materials...
May 2018: Annals of Plastic Surgery
https://www.readbyqxmd.com/read/29478253/blood-vessel-occlusion-with-erythrocyte-aggregates-causes-burn-injury-progression-microvasculature-dilation-as-a-possible-therapy
#9
Richard A F Clark, Justine Fenner, Arielle Sasson, Steve A McClain, Adam J Singer, Marcia G Tonnesen
Burns are dynamic injuries characterized by progressive tissue death and continuous severe pain over the course of several days. The extent of burn injury progression determines the ultimate patient outcome. Initial burns result in a central zone of necrosis surrounded by a potentially viable zone of ischemia. Several mechanisms have been proposed to explain injury progression, including oxidant and cytokine stress resulting from either ischemia/reperfusion and/or inflammation, but no proven therapy has emerged...
February 25, 2018: Experimental Dermatology
https://www.readbyqxmd.com/read/29403130/suicidal-nonorganophosphate-poisoning-in-a-tertiary-hospital-in-south-india-nature-prevalence-risk-factors
#10
Rohit Ninan Benjamin, Thambu David, Ramya Iyadurai, K S Jacob
Background: People who deliberately ingest poisons commonly present to emergency departments of hospitals in India. However, there is a dearth of information on poisoning using nonorganophosphorus pesticides. Methods: This prospective, hospital-based study attempted to examine the nonorganophosphorus poisons used to attempt suicide. Data on sociodemographic characteristics of patients, site and source of poisons, co-ingested substances, premeditation, and reason for poisoning were collected...
January 2018: Indian Journal of Psychological Medicine
https://www.readbyqxmd.com/read/29286326/role-of-rdw-in-prediction-of-burn-after-caustic-substance-ingestion
#11
Emrah Aydin, Omer Faruk Beser, Soner Sazak, Ensar Duras
A quantifiable, quick, inexpensive and reproducible predictor is needed to decide if caustic substance ingestion results in burn regardless of the symptoms. A multicenter cohort study was conducted to investigate the predictive value of red cell distribution width (RDW) in detecting the esophageal burns. The data of 174 patients were retrospectively analyzed. Eleven patients were excluded due to inability to define the substance ingested. Complete blood count (CBC) was taken at admission, and an esophagogastroduodenoscopy was performed within the first 12-24 h in all patients, regardless of their symptoms...
December 29, 2017: Children
https://www.readbyqxmd.com/read/29216023/corticosteroids-for-preventing-caustic-esophageal-strictures-systematic-review-and-meta-analysis
#12
Raji Katibe, Ibtihal Abdelgadir, Paraic McGrogan, Anthony K Akobeng
OBJECTIVES: Caustic ingestion can have a complicated clinical course. Corticosteroids are widely used but there is uncertainty about its role in preventing esophageal stricture formation following caustic ingestion. This systematic review and meta-analysis assessed the available clinical evidence regarding the efficacy and safety of corticosteroids for preventing esophageal strictures following caustic injury. METHODS: We assessed randomized controlled trials (RCTs) that compared corticosteroids versus no corticosteroids in the prevention of esophageal stricture formation following caustic ingestion...
June 2018: Journal of Pediatric Gastroenterology and Nutrition
https://www.readbyqxmd.com/read/29207003/risk-factors-for-symptomatic-esophageal-stricture-after-caustic-ingestion-a-retrospective-cohort-study
#13
P Le Naoures, A Hamy, N Lerolle, E Métivier, E Lermite, A Venara
Esophageal stricture is a major secondary complication of ingesting caustic agents. We examined our experiences with caustic injuries with a view to finding clinical and biological risk factors of esophageal strictures secondary to caustic ingestion. Records were retrieved for 58 adults admitted consecutively to our intensive care unit for caustic ingestion. Fifty cases were managed conservatively and therefore retained for analyses. Patients were grouped according to whether they developed strictures or not during the follow-up period...
June 1, 2017: Diseases of the Esophagus: Official Journal of the International Society for Diseases of the Esophagus
https://www.readbyqxmd.com/read/29201954/accuracy-of-endoscopy-in-predicting-the-depth-of-mucosal-injury-following-caustic-ingestion-a-cross-sectional-study
#14
Athena Alipour-Faz, Maryam Yousefi, Hassan Peyvandi
Introduction: Esophagogastroduodenoscopy (EGD) is currently considered as the primary method of determining the degree of mucosal injury following caustic ingestion. The present study aimed to evaluate the screening performance characteristics of EGD in predicting the depth of gastrointestinal mucosal injuries following caustic ingestion. Methods: Adult patients who were referred to emergency department due to ingestion of corrosive materials, over a 7-year period, were enrolled to this diagnostic accuracy study...
2017: Emergency (Tehran, Iran)
https://www.readbyqxmd.com/read/29168156/the-anesthetic-management-of-button-battery-ingestion-in-children
#15
Richard J Ing, Monica Hoagland, Lena Mayes, Mark Twite
PURPOSE: Injuries related to button battery ingestion are common in children. This review provides an outline of the epidemiology, pathophysiology, management, and anesthetic implications in children who have ingested a button battery. SOURCE: A literature search was conducted in the United States National Library of Medicine PubMed database using the terms "button battery ingestion" and "children' and "removal" and "surgery" and "anesthesia"...
March 2018: Canadian Journal of Anaesthesia, Journal Canadien D'anesthésie
https://www.readbyqxmd.com/read/29112883/a-new-paradigm-for-gerd-pathogenesis-not-acid-injury-but-cytokine-mediated-inflammation-driven-by-hif-2%C3%AE-a-potential-role-for-targeting-hif-2%C3%AE-to-prevent-and-treat-reflux-esophagitis
#16
REVIEW
Rhonda F Souza, Liela Bayeh, Stuart J Spechler, Uttam K Tambar, Richard K Bruick
Traditionally, reflux esophagitis was assumed to develop as a caustic, chemical injury inflicted by refluxed acid. Recently, however, studies in rats and humans suggest that reflux esophagitis develops as a cytokine-mediated inflammatory injury, with hypoxia inducible factor (HIF)-2α playing a major role. In response to the reflux of acid and bile, HIF-2α in esophageal epithelial cells becomes stabilized, thereby increasing production of pro-inflammatory cytokines that attract T lymphocytes and other inflammatory cells to damage the esophagus...
December 2017: Current Opinion in Pharmacology
https://www.readbyqxmd.com/read/29036912/caustic-ingestion-in-the-elderly-influence-of-age-on-clinical-outcome
#17
Blazena Caganova, Tatiana Foltanova, Erik Puchon, Elena Ondriasova, Silvia Plackova, Tomas Fazekas, Magdalena Kuzelova
Caustic poisonings are still associated with many fatalities. Studies focusing on the elderly are rare. The purpose of the present study was to compare the clinical outcomes of caustic ingestion injury in elderly and non-elderly adults with regard to gender, intent of exposure, substance ingested, severity of mucosal injury, complications, and mortality. Caustic substance exposures reported to the National Toxicological Information Centre in Slovakia during 1998-2015 were reviewed retrospectively. The patients were divided into two groups: the non-elderly (<60 years) and elderly adults (≥60 years)...
October 14, 2017: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
https://www.readbyqxmd.com/read/28963377/a-frog-in-the-throat
#18
Hunniya Waseem, Matthew Welch
CLINICAL INTRODUCTION: A 44-year-old woman, with an unremarkable medical history, presented in the middle of the night with discomfort in her throat. She described being assaulted by an assailant who put his 'fist in her mouth', trying to suffocate her. On examination, she had normal observations and no signs of injury, other than scratch marks around her mouth; she reported no odynophagia and was able to swallow fluids readily. During examination, she complained that lying flat made her increasingly uncomfortable and was causing burgeoning dyspnoea...
October 2017: Emergency Medicine Journal: EMJ
https://www.readbyqxmd.com/read/28894776/diagnostic-accuracy-of-computed-tomography-scan-in-detection-of-upper-gastrointestinal-tract-injuries-following-caustic-ingestion
#19
Hooman Bahrami-Motlagh, Mohammad Hadizadeh-Neisanghalb, Hassan Peyvandi
INTRODUCTION: Endoscopy is an invasive procedure and finding noninvasive alternative tools in detection of probable upper gastrointestinal (GI) tract injuries following caustic ingestion is an area of interest. The present study aimed to evaluate the screening performance characteristics of thoraco-abdominal computed tomography (CT) scan in this regard. METHODS: This prospective cross sectional study was conducted on patients presenting to emergency department following acute caustic ingestion...
2017: Emergency (Tehran, Iran)
https://www.readbyqxmd.com/read/28894772/epidemiologic-features-and-outcomes-of-caustic-ingestions-a-10-year-cross-sectional-study
#20
Athena Alipour Faz, Fahimeh Arsan, Hassan Peyvandi, Mahbobeh Oroei, Omid Shafagh, Maryam Peyvandi, Maryam Yousefi
INTRODUCTION: Caustic ingestions are among the most prevalent causes of toxic exposure. The present 10-year survey aimed to evaluate the epidemiologic features and outcomes of caustic ingestion cases presenting to emergency department. METHODS: This is a retrospective cross-sectional study on patients who were admitted to a referral toxicology center during 2004 to 2014, following caustic ingestion. Baseline characteristics, presenting chief complaint, severity of mucosal injury, complications, imaging and laboratory findings as well as outcomes (need for ICU admission, need for surgery, mortality) were recorded, reviewing patients' medical profile, and analyzed using SPSS 22...
2017: Emergency (Tehran, Iran)
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