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https://www.readbyqxmd.com/read/27859311/basic-mechanism-of-button-battery-ingestion-injuries-and-novel-mitigation-strategies-after-diagnosis-and-removal
#1
Kris R Jatana, Keith Rhoades, Scott Milkovich, Ian N Jacobs
OBJECTIVES/HYPOTHESIS: Button battery (BB) injuries continue to be a significant source of morbidity and mortality, and there is a need to confirm the mechanism of injury for development of additional mitigation strategies. STUDY DESIGN: Cadaveric piglet esophageal model. METHODS: Lithium, silver oxide, alkaline, and zinc-air BBs were placed in thawed sections of cadaveric piglet esophagus, bathed in normal saline. Severity of gross visual burn, pH, and temperature were recorded every 30 minutes for 6 hours...
November 9, 2016: Laryngoscope
https://www.readbyqxmd.com/read/27785326/a-rare-disease-of-the-digestive-tract-esophageal-melanosis
#2
Sebahattin Destek, Vahit Onur Gul, Serkan Ahioglu, Yesim Erbil
Esophageal melanosis which is characterized by melanocytic proliferation in the squamous epithelium of the esophagus and melanin accumulatin of esophageal mucosa (EM) is a rare disease of the digestive system. Although esophageal melanosis is considered to be a benign disease, its etiology is not cleared and has been reported to be the precursor lesion of esophageal primary melanomas. In this report, we aimed to note esophageal melanosis in a 55-year-old female case who applied to our clinic with difficulty in swallowing, burning behind the breastbone in the stomach, heartburn, indigestion, and pain in the upper abdomen after endoscopic and pathologic evaluation...
June 2016: Gastroenterology Research
https://www.readbyqxmd.com/read/27576447/association-between-off-hour-presentation-and-endotracheal-intubation-related-adverse-events-in-trauma-patients-with-a-predicted-difficult-airway-a-historical-cohort-study-at-a-community-emergency-department-in-japan
#3
Yuko Ono, Takuya Sugiyama, Yasuyuki Chida, Tetsuya Sato, Hiroaki Kikuchi, Daiji Suzuki, Masakazu Ikeda, Koichi Tanigawa, Kazuaki Shinohara
BACKGROUND: A reduction in medical staff such as occurs in hospitals during nights and weekends (off hours) is associated with a worse outcome in patients with several unanticipated critical conditions. Although difficult airway management (DAM) requires the simultaneous assistance of several appropriately trained medical caregivers, data are scarce regarding the association between off-hour presentation and endotracheal intubation (ETI)-related adverse events, especially in the trauma population...
2016: Scandinavian Journal of Trauma, Resuscitation and Emergency Medicine
https://www.readbyqxmd.com/read/27431077/-a-clinical-study-of-fungal-esophagitis-in-13-patients-with-hematologic-malignancies
#4
Y L Zhou, X D Wei, R H Mi, H Ai, L N Zhang, Y Y Liu, Y F Li, Y P Song
OBJECTIVE: To improve the clinical understanding of fungal esophagitis in patients with hematologic malignancies. METHOD: The clinical data of a cohort of 279 patients with hematologic malignancies who underwent gastroscopy between 2012 and 2015 in the Endoscopy Center of Henan Tumor Hospital were retrospectively analyzed. To investigate the clinical characteristics and prognosis of fungal esophagitis in patients with heratologic malignancies. RESULTS: 13 of the 279 patients were diagnosed as fungal esophagitis (4...
June 14, 2016: Zhonghua Xue Ye Xue za Zhi, Zhonghua Xueyexue Zazhi
https://www.readbyqxmd.com/read/27424019/caustic-agent-ingestion-by-a-1-5-year-old-boy
#5
Behdad Gharib, Masoud Mohammadpour, Bahareh Yaghmaie, Meisam Sharifzadeh, Mehrzad Mehdizadeh, Fatemeh Zamani, Rouhollah Edalatkhah, Reihaneh Mohsenipour
We present a case of caustic ingestion by a 1.5-year-old boy. The caustic agent was drain opener which is a strong alkaline substance. Children in Iran and many other countries are still exposed to not "child proof" (child resistant packaging) toxic substance containers. Ingestion of caustic agents may lead to necrosis, perforation, and strictures. Substances that are ingested more frequently are liquid alkali material which causes severe, deep liquefaction necrosis. Common signs and symptoms of caustic agents are vomiting, drooling, refusal to drink, oral burns, stridor, hematemesis, dyspnea, dysphagia and abdominal pain...
July 2016: Acta Medica Iranica
https://www.readbyqxmd.com/read/27373284/-a-comparison-of-clinical-characteristics-between-non-erosive-reflux-disease-and-reflux-esophagitis
#6
H Y Pan, X L Xiang, S Z Lyu, X P Xie, X H Hou
Objective: To summarize the clinical symptoms of patients with non-erosive reflux disease(NERD) and reflux esophagitis(RE), which is helpful to the differential diagnosis. Methods: Out-patients who met the criteria of NERD or RE according to the Montreal definition in Gastroenterology Department Wuhan Union Hospital from 2010-2014 were enrolled in our study. Clinical data were comprehensively collected. Incidence of disease, severity, frequency of esophageal and extraesophageal symptoms, and the rates of overlapping with functional dyspepsia (FD) or irritable bowel syndrome (IBS) were all studied...
July 1, 2016: Zhonghua Nei Ke za Zhi [Chinese Journal of Internal Medicine]
https://www.readbyqxmd.com/read/27319353/somatically-acquired-line-1-insertions-in-normal-esophagus-undergo-clonal-expansion-in-esophageal-squamous-cell-carcinoma
#7
Tara T Doucet-O'Hare, Reema Sharma, Nemanja Rodić, Robert A Anders, Kathleen H Burns, Haig H Kazazian
Squamous cell carcinoma of the esophagus (SCC) is the most common form of esophageal cancer in the world and is typically diagnosed at an advanced stage when successful treatment is challenging. Understanding the mutational profile of this cancer may identify new treatment strategies. Because somatic retrotransposition has been shown in tumors of the gastrointestinal system, we focused on LINE-1 (L1) mobilization as a source of genetic instability in this cancer. We hypothesized that retrotransposition is ongoing in SCC patients...
September 2016: Human Mutation
https://www.readbyqxmd.com/read/27250962/-a-systematic-review-of-the-literature-related-to-elevating-the-head-of-the-bed-for-patients-with-gastroesophageal-reflux-disease-applications-in-patients-after-esophageal-cancer-surgery
#8
REVIEW
Hui-Chen Huang, Su-Ying Fang
BACKGROUND: Acid regurgitation typically worsens during nighttime sleep, which influences the quality of life of patients and potentially causes pathological changes. As much as 80% of esophageal cancer patients experience acid regurgitation following esophagectomy and reconstruction surgery. Thus, improving this symptom is important to improving the quality of life of these patients. PURPOSE: The purpose of the present study was to evaluate the effect of elevating the head of the bed for patients with gastroesophageal reflux disease (GERD)...
June 2016: Hu Li za Zhi the Journal of Nursing
https://www.readbyqxmd.com/read/27158397/a-novel-biodegradable-esophageal-stent-results-from-mechanical-and-animal-experiments
#9
Jin Liu, Liang Shang, Jiyong Liu, Chengyong Qin
Biodegradable esophageal stents eliminate stent retrieval, but usually induce hyperplasia. This study investigated the properties of a novel biodegradable stent in vitro and in vivo. The degradation of the novel stent was observed in phosphate buffered saline (PBS) for 8 weeks. The radial forces, pH values, morphology, and retention rate of the intrinsic viscosity (R[η]) of the new biodegradable stent were all evaluated. In vitro, the pH values remained constant for 4 weeks and declined from weeks 4 to 8. The biodegradable threads degraded and ruptured at 6 weeks...
2016: American Journal of Translational Research
https://www.readbyqxmd.com/read/27043177/evaluation-of-advanced-cooling-therapy-s-esophageal-cooling-device-for-core-temperature-control
#10
Melissa Naiman, Patrick Shanley, Frank Garrett, Erik Kulstad
Managing core temperature is critical to patient outcomes in a wide range of clinical scenarios. Previous devices designed to perform temperature management required a trade-off between invasiveness and temperature modulation efficiency. The Esophageal Cooling Device, made by Advanced Cooling Therapy (Chicago, IL), was developed to optimize warming and cooling efficiency through an easy and low risk procedure that leverages heat transfer through convection and conduction. Clinical data from cardiac arrest, fever, and critical burn patients indicate that the Esophageal Cooling Device performs very well both in terms of temperature modulation (cooling rates of approximately 1...
May 2016: Expert Review of Medical Devices
https://www.readbyqxmd.com/read/27018074/use-of-an-esophageal-heat-exchanger-to-maintain-core-temperature-during-burn-excisions-and-to-attenuate-pyrexia-on-the-burns-intensive-care-unit
#11
David Williams, Gordon Leslie, Dimitrios Kyriazis, Benjamin O'Donovan, Joanne Bowes, John Dingley
Introduction. Burns patients are vulnerable to hyperthermia due to sepsis and SIRS and to hypothermia due to heat loss during excision surgery. Both states are associated with increased morbidity and mortality. We describe the first use of a novel esophageal heat exchange device in combination with a heater/cooler unit to manage perioperative hypothermia and postoperative pyrexia. Material and Methods. The device was used in three patients with full thickness burns of 51%, 49%, and 45% body surface area to reduce perioperative hypothermia during surgeries of >6 h duration and subsequently to control hyperthermia in one of the patients who developed pyrexia of 40°C on the 22nd postoperative day due to E...
2016: Case Reports in Anesthesiology
https://www.readbyqxmd.com/read/26986168/epigastric-distress-caused-by-esophageal-candidiasis-in-2-patients-who-received-sorafenib-plus-radiotherapy-for-hepatocellular-carcinoma-case-report
#12
Kuo-Hsin Chen, Meng-Tzu Weng, Yueh-Hung Chou, Yueh-Feng Lu, Chen-Hsi Hsieh
Sorafenib followed by fractionated radiotherapy (RT) has been shown to decrease the phagocytic and candidacidal activities of antifungal agents due to radiosensitization. Moreover, sorafenib has been shown to suppress the immune system, thereby increasing the risk for candida colonization and infection. In this study, we present the 2 hepatocellular carcinoma (HCC) patients suffered from epigastric distress caused by esophageal candidiasis who received sorafenib plus RT. Two patients who had received sorafenib and RT for HCC with bone metastasis presented with hiccups, gastric ulcer, epigastric distress, anorexia, heart burn, and fatigue...
March 2016: Medicine (Baltimore)
https://www.readbyqxmd.com/read/26834850/pediatric-obesity-causes-symptoms-prevention-and-treatment
#13
Shumei Xu, Ying Xue
Pediatric or childhood obesity is the most prevalent nutritional disorder among children and adolescents worldwide. Approximately 43 million individuals are obese, 21-24% children and adolescents are overweight, and 16-18% of individuals have abdominal obesity. The prevalence of obesity is highest among specific ethnic groups. Obesity increases the risk of heart diseases in children and adults. Childhood obesity predisposes the individual to insulin resistance and type 2 diabetes, hypertension, hyperlipidemia, liver and kidney diseases and causes reproductive dysfunction in adults...
January 2016: Experimental and Therapeutic Medicine
https://www.readbyqxmd.com/read/26710478/effect-of-h-pylori-density-by-histopathology-on-its-complications-and-eradication-therapy
#14
Dharmesh K Shah, Samit S Jain, Ashok Mohite, Anjali D Amarapurkar, Q Q Contractor, Pravin M Rathi
INTRODUCTION: Helicobacter pylori (H. pylori) infection causes chronic gastritis and is a major risk factor for duodenal and gastric ulceration, gastric adenocarcinoma, and primary gastric lymphoma. Increased gastric bacterial density may lead to increased levels of inflammation and epithelial injury. AIMS AND OBJECTIVES: 1) To study the effect of H. pylori density by histological changes in stomach. 2) To study the effect of H. pylori density on the efficacy of standard triple drug eradication treatment...
April 2015: Tropical Gastroenterology: Official Journal of the Digestive Diseases Foundation
https://www.readbyqxmd.com/read/26687065/conservative-management-of-severe-caustic-injuries-during-acute-phase-leads-to-superior-long-term-nutritional-and-quality-of-life-qol-outcome
#15
K Raynaud, D Seguy, M Rogosnitzky, F Saulnier, F R Pruvot, Philippe Zerbib
PURPOSE: Best clinical management of severe caustic injury is still a subject of debate. Most surgical teams consider severe caustic injury as an indication for emergency surgery. But, under certain circumstances, conservative management is feasible, avoids the need for gastrectomy, and has a low mortality rate. Postponed reconstructive surgery is usually performed several months after caustic ingestion to restore intestinal continuity or to treat stricture sequelae. This study aimed to investigate long-term nutritional and quality of life (QoL) outcomes after reconstructive surgery for high-grade esophageal and gastric caustic injury...
February 2016: Langenbeck's Archives of Surgery
https://www.readbyqxmd.com/read/26488101/-partynight-outcome
#16
Anne Frederike Wunder, Michael Oelckers, Guntram Lock
HISTORY AND CLINICAL FINDINGS: An 18 year old girl was admitted with progressive painful dysphagia and a severe hemorrhagic endoscopically impassable esophagitis. She reported to have consumed an unknown liquid from a small flask on a party three weeks ago. Later on, this liquid was identified as a party- and sex-drug known as "Poppers", designed to be consumed by sniffing. On admission she had difficulties in swallowing liquids and even saliva. She had lost 8 kg of weight during the last 3 weeks...
October 2015: Deutsche Medizinische Wochenschrift
https://www.readbyqxmd.com/read/26469108/experimental-esophagitis-model-preventing-tracheal-aspiration
#17
Hasan A Kiraz, Mesut Erbas, Adem Kucuk, Naci Topaloglu, Havva Erdem, Hasan Sahin, Huseyin Toman, Aslı Kiraz
BACKGROUND: Corrosive esophagitis injuries are a serious clinical problem with many agents used for diagnosis and treatment. Experimental esophagus burn models use a method described mainly in studies by Gehanno and Guedon, and modified by Liu and Richardson. OBJECTIVES: The aim of this study was to describe a new esophagitis model that prevents tracheal aspiration. MATERIAL AND METHODS: In this study we used 16 Wistar albino rats weighing between 220-240 g...
July 2015: Advances in Clinical and Experimental Medicine: Official Organ Wroclaw Medical University
https://www.readbyqxmd.com/read/26460850/monitoring-neutrophil-expressed-cell-surface-esophageal-cancer-related-gene-4-after-severe-burn-injury
#18
Todd W Costantini, Raul Coimbra, Nicole E Lopez, Jeanne G Lee, Bruce Potenza, Alan Smith, Andrew Baird, Brian P Eliceiri
BACKGROUND: We identified recently esophageal cancer related gene-4 (ECRG4) as a candidate cytokine that is expressed on the surface of quiescent polymorphonuclear leukocytes (PMNs) and shed in response to ex vivo treatment with lipopolysaccharide. To investigate the potential biologic relevance of changes in cell surface ECRG4 in human samples, we performed a pilot study to examine a population of burn patients in whom blood could be analyzed prospectively. We hypothesized that cutaneous burn injury would alter cell surface expression of ECRG4 on PMNs...
December 2015: Surgical Infections
https://www.readbyqxmd.com/read/26452739/pradaxa-induced-esophageal-ulcer
#19
Michele Wood, Paul Shaw
Pradaxa (dabigatran) is a direct thrombin inhibitor approved for prevention of stroke and systemic embolism in patients with non-valvular atrial fibrillation. We describe a case of esophageal ulceration associated with Pradaxa administration in a 75-year-old man. The patient reported difficulty swallowing and a burning sensation after taking his first dose of Pradaxa. An esophagogastroduodenoscopy (EGD) revealed linear ulcerations in the mid-esophagus. Pradaxa was held beginning the day before the EGD. The patient reported that his pain and difficulty swallowing resolved on stopping Pradaxa...
2015: BMJ Case Reports
https://www.readbyqxmd.com/read/26283398/line-1-expression-and-retrotransposition-in-barrett-s-esophagus-and-esophageal-carcinoma
#20
Tara T Doucet-O'Hare, Nemanja Rodić, Reema Sharma, Isha Darbari, Gabriela Abril, Jungbin A Choi, Ji Young Ahn, Yulan Cheng, Robert A Anders, Kathleen H Burns, Stephen J Meltzer, Haig H Kazazian
Barrett's esophagus (BE) is a common disease in which the lining of the esophagus transitions from stratified squamous epithelium to metaplastic columnar epithelium that predisposes individuals to developing esophageal adenocarcinoma (EAC). We hypothesized that BE provides a unique environment for increased long-interspersed element 1 (LINE-1 or L1) retrotransposition. To this end, we evaluated 5 patients with benign BE, 5 patients with BE and concomitant EAC, and 10 additional patients with EAC to determine L1 activity in this progressive disease...
September 1, 2015: Proceedings of the National Academy of Sciences of the United States of America
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