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https://www.readbyqxmd.com/read/27325144/effects-of-montelukast-on-m2-related-cytokine-and-chemokine-in-m2-macrophages
#1
Yi-Ching Lin, Ming-Yii Huang, Min-Sheng Lee, Chong-Chao Hsieh, Hsuan-Fu Kuo, Chang-Hung Kuo, Chih-Hsing Hung
BACKGROUND/PURPOSE: Asthma is a chronic airway inflammatory disease mediated by T-helper (Th)2 cells. Montelukast (trade name Singulair) is a cysteinyl leukotriene receptor antagonist used for asthma treatment. Mirroring Th1-Th2 polarization, two distinct states of macrophages have been recognized: the classically activated (M1) macrophages and the alternatively activated (M2) macrophages. M2 polarization is known to be a response to the Th2 cytokines; however, the effects of montelukast on M2 macrophages have not been well characterized...
May 13, 2016: Journal of Microbiology, Immunology, and Infection, Wei Mian Yu Gan Ran za Zhi
https://www.readbyqxmd.com/read/27228637/churg-strauss-syndrome-singulair-or-silicone-or-both
#2
Paula R David, Amir Dagan, Maartje Colaris, Mintsje de Boer, Jan W Cohen Tervaert, Yehuda Shoenfeld
No abstract text is available yet for this article.
March 2016: Israel Medical Association Journal: IMAJ
https://www.readbyqxmd.com/read/26642646/-the-effect-of-generic-price-competition-on-drug-consumption-and-health-insurance-pharmaceutical-expenditures-in-hungary
#3
Balázs Répásy, Dóra Endrei, Antal Zemplényi, István Agoston, Lajos Hornyák, Zsolt Nagy, Tímea Csákvári, Réka Vajda, Boncz Imre
AIM: The aim of our study was to analyze the Hungarian montelukast sodium drug market. We examined the effect of the appearance of generic drugs on the price and turnover of the brand-name drug, Singulair. DATA AND METHODS: Data derived from the nationwide pharmaceutical database of Hungarian National Health Insurance Fund Administration (2007-2014). We analized the turnover and price of the medicaments containing the active substance montelukast sodium. Accordingly our indicators were: consumer price, social insurance subsidy, patients' co-payment and days of treatment (DOT)...
2015: Acta Pharmaceutica Hungarica
https://www.readbyqxmd.com/read/26634774/a-low-literacy-asthma-action-plan-to-improve-provider-asthma-counseling-a-randomized-study
#4
RANDOMIZED CONTROLLED TRIAL
H Shonna Yin, Ruchi S Gupta, Suzy Tomopoulos, Alan L Mendelsohn, Maureen Egan, Linda van Schaick, Michael S Wolf, Dayana C Sanchez, Christopher Warren, Karen Encalada, Benard P Dreyer
BACKGROUND AND OBJECTIVES: The use of written asthma action plans (WAAPs) has been associated with reduced asthma-related morbidity, but there are concerns about their complexity. We developed a health literacy-informed, pictogram- and photograph-based WAAP and examined whether providers who used it, with no training, would have better asthma counseling quality compared with those who used a standard plan. METHODS: Physicians at 2 academic centers randomized to use a low-literacy or standard action plan (American Academy of Allergy, Asthma and Immunology) to counsel the hypothetical parent of child with moderate persistent asthma (regimen: Flovent 110 μg 2 puffs twice daily, Singulair 5 mg daily, Albuterol 2 puffs every 4 hours as needed)...
January 2016: Pediatrics
https://www.readbyqxmd.com/read/26561521/interchangeability-and-comparative-effectiveness-between-generic-and-brand-montelukast-immediate-release-tablets-after-a-single-oral-administration-in-healthy-volunteers
#5
Abdel Naser Zaid, Ayman Mousa, Nadia Ghazal, Rana Bustami
BACKGROUND: Montelukast is a leukotriene receptor antagonist. The release of leukotrienes causes narrowing and constricting in the respiratory airways. Blocking the action of these leukotrienes, montelukast can be used for the prophylaxis and treatment of chronic asthma. OBJECTIVE: The aim of this study was to evaluate the interchangeability and comparative effectiveness between a generic and a brand montelukast 10 mg immediate release tablets (Broncast(®) and Singulair(®), respectively) after a single oral dose among Arab Mediterranean volunteers...
2015: Clinical and Translational Allergy
https://www.readbyqxmd.com/read/26512261/the-efficacy-and-safety-of-montelukast-sodium-in-the-prevention-of-bronchopulmonary-dysplasia
#6
Sang Bum Kim, Jang Hoon Lee, Juyoung Lee, Seung Han Shin, Ho Sun Eun, Soon Min Lee, Jin A Sohn, Han Suk Kim, Byung Min Choi, Min Soo Park, Kook In Park, Ran Namgung, Moon Sung Park
PURPOSE: The purpose of this study was to evaluate the efficacy and safety of Montelukast sodium in the prevention of bronchopulmonarydysplasia (BPD). METHODS: The Interventional study was designed as a multicenter, prospective, and randomized trial, with open labeled and parallel-experimental groups, 66 infants were enrolled and allocated to either the case group (n=30) or the control group (n=36) based on gestational age (GA). Infants in the case group were given Montelukast sodium (Singulair) based on their body weight (BW)...
September 2015: Korean Journal of Pediatrics
https://www.readbyqxmd.com/read/26505715/prevention-of-capsular-contracture-using-leukotriene-antagonists
#7
COMPARATIVE STUDY
Ruth Graf, Adriana S K Ascenço, Renato da S Freitas, Priscilla Balbinot, Carolina Peressutti, Diogo F B Costa, Fábio de H C R Dos Santos, Marco A S Ratti, Rodrigo M Kulchetscki
BACKGROUND: Capsular contracture is a common occurrence in plastic surgery, with a prevalence varying from 0.5 percent up to 30 percent. Although the standard treatment is capsulectomy, alternative treatments have been studied, such as the use of leukotriene inhibitors. These drugs have recently been evaluated in the prophylaxis of contracture. The authors aimed to assess the efficacy of montelukast (Singulair) in the prevention of capsular contracture in patients undergoing mammaplasty with textured silicone prostheses...
November 2015: Plastic and Reconstructive Surgery
https://www.readbyqxmd.com/read/26451086/investigation-of-the-bioequivalence-of-montelukast-chewable-tablets-after-a-single-oral-administration-using-a-validated-lc-ms-ms-method
#8
RANDOMIZED CONTROLLED TRIAL
Abdel Naser Zaid, Murad N Abualhasan, David G Watson, Ayman Mousa, Nadia Ghazal, Rana Bustami
BACKGROUND: Montelukast (MT) is a leukotriene D4 antagonist. It is an effective and safe medicine for the prophylaxis and treatment of chronic asthma. It is also used to prevent acute exercise-induced bronchoconstriction and as a symptomatic relief of seasonal allergic rhinitis and perennial allergic rhinitis. OBJECTIVE: The aim of this study was to evaluate the bioequivalence (BE) of two drug products: generic MT 5 mg chewable tablets versus the branded drug Singulair(®) pediatric 5 mg chewable tablets among Mediterranean volunteers...
2015: Drug Design, Development and Therapy
https://www.readbyqxmd.com/read/25879303/effect-of-direct-to-consumer-advertising-on-asthma-medication-sales-and-healthcare-use
#9
Matthew Daubresse, Susan Hutfless, Yoonsang Kim, Rachel Kornfield, Dima M Qato, Jidong Huang, Kay Miller, Sherry L Emery, G Caleb Alexander
RATIONALE: The United States is one of only two countries that permit direct-to-consumer advertising (DTCA) of prescription drugs, and many questions remain regarding its effects. OBJECTIVES: To quantify the association between asthma-related DTCA, pharmacy sales, and healthcare use. METHODS: This was an ecological study from 2005 through 2009 using linked data from Nielsen (DTCA television ratings), the IMS Health National Prescription Audit (pharmacy sales), and the MarketScan Commercial Claims data (healthcare use) for 75 designated market areas in the United States...
July 1, 2015: American Journal of Respiratory and Critical Care Medicine
https://www.readbyqxmd.com/read/25250173/bioequivalence-of-two-formulations-of-montelukast-sodium-4-mg-oral-granules-in-healthy-adults
#10
Constanze Fey, Ursula Thyroff-Friesinger, Spencer Jones
Montelukast is an effective and well-tolerated treatment for the prophylaxis and chronic treatment of asthma, acute prevention of exercise-induced bronchoconstriction and symptomatic relief of seasonal allergic rhinitis and perennial allergic rhinitis. The aim of the study was to compare bioavailability, and characterise the pharmacokinetic profile and safety of Sandoz generic montelukast 4 mg oral granules relative to Singulair(®) mini (Merck, Sharp & Dohme). An open-label, randomised, single-dose, two-treatment, two-period, two-sequence, two-way crossover bioequivalence study was conducted in healthy male volunteers aged 18-55 years, under fasting conditions...
2014: Clinical and Translational Allergy
https://www.readbyqxmd.com/read/25055192/continuous-recycling-of-homogeneous-pd-cu-catalysts-for-cross-coupling-reactions
#11
Siddharth Sharma, K C Basavaraju, Ajay K Singh, Dong-Pyo Kim
Given the importance of homogeneous catalysts recycling in organic chemistry, we have developed a unique microfluidic loop system for automated continuous recirculation of a soluble polymer supported metal catalyst for novel isocyanide cross-coupling reactions under thermomorphic multicomponent solvent (TMS) conditions. Our system provides an innovative approach for the chemical library synthesis of quinazolinone derivatives as well as an important intermediate of Merck's LTD4 antagonist "Singulair" with efficient continuous homogeneous catalyst recycling...
August 1, 2014: Organic Letters
https://www.readbyqxmd.com/read/24133311/effects-of-montelukast-sodium-on-tendon-healing-an-experimental-study
#12
Atilla Polat, Mehmet Kerem Canbora, Dilek Akakin, Faruk Aykanat
INTRODUCTION: Montelukast sodium (MS) a selective leukotriene antagonist of the cysteinyl leukotriene receptor, has been used in the treatment of asthma and allergic rhinitis. In this study, we evaluated the effect of MS on the early inflammatory phase (histological) of nonsynovial tendon healing. MATERIALS AND METHODS: Rats were divided randomly into two groups (n = 6 each). MS (Singulair) was administered to one group at 10 mg/kg/day [250 g/day intraperitoneally (i...
September 2013: Indian Journal of Orthopaedics
https://www.readbyqxmd.com/read/23830305/asthma-diagnosis-and-severity-monitoring-in-primary-school-children-essential-role-of-sequential-testing-of-exhaled-nitric-oxide
#13
K-S Wan, W-H Chiu, W Yang
BACKGROUND: Chronic eosinophilic airway inflammation, airflow limitation, and airway hyper-responsiveness are the mainstays of asthma diagnosis. The increased levels of exhaled nitric oxide (FeNO) in asthma are closely related to the extent of airway inflammation. Sequential measurement of FeNO concentrations may accurately predict asthma severity and guide therapeutic decisions. METHODS: A total of 22,083 grade 1 students in Taipei city primary schools were screened for wheezing episodes using the International Study of Asthma and Allergies in Childhood questionnaire (ISAAC) questionnaires while their sero-atopic conditions were confirmed by Fluorescent Enzyme Immune Assay (FEIA)...
September 2014: Allergologia et Immunopathologia
https://www.readbyqxmd.com/read/23715188/-bioequivalence-study-of-montelukast-5-mg-chewable-tablets
#14
RANDOMIZED CONTROLLED TRIAL
Angela Piedad Medina, Francisco Javier Olaya, Mónica Patricia Navas, Angela María Tilano, Enrique Muñoz
INTRODUCTION: The importance of generic drugs is the possibility of reduced costs in the national health system without sacrificing quality of service and the efficacy and safety of treatments. However, bioequivalence studies must show that the pharmacokinetic profiles of the test product and reference product are similar and interchangeable. Montelukast sodium is indicated for the prophylaxis and chronic treatment of asthma in adults and pediatric patients 12 months of age or older. It is generally well tolerated, although adverse reactions are more frequent in patients treated with the drug than in those treated with placebo...
September 2012: Biomédica: Revista del Instituto Nacional de Salud
https://www.readbyqxmd.com/read/23455193/bioequivalence-study-of-montelukast-tablets-in-healthy-pakistani-volunteers
#15
RANDOMIZED CONTROLLED TRIAL
Mateen Abbas, Abdul Muqeet Khan, Sadia Amin, Sualeha Riffat, Muhammad Ashraf, Naila Waheed
Montelukast is a leukotrien receptor antagonist used for asthma treatment. Objective of this study was to evaluate the bioequivalence of two montelukast 10mg tablets, Innovator drug (Singulair) as reference and other locally manufactured drug (Montiget) in 12 healthy volunteers. It was randomized, single dose, two-period crossover study with 1 week washout period. Blood samples (4-5 ml) were collected before and after drug administration and plasma was separated for analysis. Concentrations of montelukast at different time intervals were determined by validated UV-HPLC method at 345nm wavelength...
March 2013: Pakistan Journal of Pharmaceutical Sciences
https://www.readbyqxmd.com/read/23430138/formulation-and-in-vitro-and-in-vivo-evaluation-of-film-coated-montelukast-sodium-tablets-using-opadry%C3%A2-yellow-20a82938-on-an-industrial-scale
#16
RANDOMIZED CONTROLLED TRIAL
Abdel Naser Zaid, Salam Natour, Aiman Qaddomi, Abeer Abu Ghoush
PURPOSE: The aim of this study was to formulate stable film-coated montelukast sodium (MS) tablets using Opadry(®) yellow 20A82938 (Montikast(®) tablets) and to evaluate their in vitro and in vivo release profile. METHODS: MS core tablets were manufactured using a direct compression method. Opadry yellow 20A82938 aqueous coating dispersion was used as the film-coating material. Dissolution of the film-coated tablets was tested in 900 mL of 0.5% sodium lauryl sulfate solution and the bioequivalence of the tablets was tested by comparing them with a reference formulation - Singulair(®) tablets...
2013: Drug Design, Development and Therapy
https://www.readbyqxmd.com/read/23375423/-psychiatric-disorders-associated-with-montelukast-data-from-the-national-pharmacovigilance-database
#17
M-S Marchand, A-P Jonville-Béra, E Autret-Leca
Montelukast (Singulair(®)) has been the subject of post-marketing warnings about psychiatric events occurring that had not been identified during clinical trials. The objective of this study was to take stock of the adverse events (AEs) related to montelukast reported in France. Cases of psychiatric disorders reported to regional pharmacovigilance centers (CRPV) and the literature data were analyzed. The 56psychiatric AEs account for 20% of all AEs reported in the montelukast CRPV: essentially sleep disorders, behavioral disorders and depression...
March 2013: Archives de Pédiatrie: Organe Officiel de la Sociéte Française de Pédiatrie
https://www.readbyqxmd.com/read/22724276/humanized-mouse-model-used-to-monitor-muc-gene-expression-in-nasal-polyps-and-to-preclinically-evaluate-the-efficacy-of-montelukast-in-reducing-mucus-production
#18
Joel M Bernstein, Heather Lehman, Maciej Lis, Amy Sands, Gregory E Wilding, Leonard Shultz, Richard Bankert, Libuse Bobek
OBJECTIVES: To determine whether MUC gene expression could be down-regulated in nasal polyps by the leukotriene receptor antagonist montelukast, we developed a system in which nondisrupted human nasal polyps could be successfully implanted into severely immunocompromised mice, and in which the histopathology of the original nasal polyp tissue could be preserved for long periods. In addition, the histopathologic changes in the human nasal polyps were carefully examined to determine the origin of the submucosal glands (SMGs) that develop in true nasal polyps found in the anterior third of the nose...
May 2012: Annals of Otology, Rhinology, and Laryngology
https://www.readbyqxmd.com/read/22407900/relative-bioavailability-of-two-5-mg-montelukast-sodium-chewable-tablets-a-single-dose-randomized-open-label-2-period-crossover-comparison-in-healthy-korean-adult-male-volunteers
#19
RANDOMIZED CONTROLLED TRIAL
H T Kim, Y-K Song, S D Lee, Y Park, C-K Kim
Montelukast sodium, cysteinyl leukotriene receptor 1 specific antagonist, has been marketed in Korea for the treatment of bronchial asthma and allergic rhinitis. The aim of this study was to compare the pharmacokinetics and relative bioavailability of a test and reference formulation of montelukast 5-mg chewable tablets in healthy Korean male volunteers to meet KFDA regulatory criteria for marketing of the new generic formulation. This study was designed as a single-dose, 2-treatment, and 2-period crossover trial with 32 healthy volunteers...
March 2012: Arzneimittel-Forschung
https://www.readbyqxmd.com/read/22203119/anti-cholinergic-effect-of-singulair-on-isolated-rat-s-tracheal-smooth-muscle
#20
Li-Hsiang Cheng, Chuan-Hsiang Kao, Chih-Hung Wang, Yueng-Hsiang Chu, Jia-Yi Wang, Hsing-Won Wang
Singulair (Montelukast) is a potent and selective leukotriene D(4) receptor antagonist, often used in treating inflammatory conditions of the respiratory system such as allergic rhinitis and asthma. However, the effects of singulair given intratracheally have rarely been well explored. To verify the effect of singulair, which acts on the tracheal smooth muscle directly in vitro. We used our preparation to test the effects of singulair on isolated rat's tracheal smooth muscle. The following assessments of singulair were performed: (1) effect on the tracheal smooth muscle resting tension, (2) effect on contraction caused by 10(-6) M methacholine as a parasympathetic mimetic, and (3) effect of the drugs on electrically induced tracheal smooth muscle contractions...
August 2012: European Archives of Oto-rhino-laryngology
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