Ha Ryeong Lee, Hyun Jin Park, Jun Soo Park, Dong Woo Park, Myoung Jin Ho, Dong Yoon Kim, Hyo Chun Lee, Eun Jeong Kim, Woo Heon Song, Jun Sang Park, Yong Seok Choi, Myung Joo Kang
Oral montelukast (MTK) is prescribed to treat asthma or rhinitis, and is clinically investigated as new medication in the treatment of Alzheimer's dementia. Herein, in order to better patient's compliance, microsuspensions (MSs)-based oral liquid preparations of montelukast (MTK) were formulated with polymeric suspending agents including hypromellose (HPMC), and those drug-polymer interaction, physicochemical stability, dissolution, and in vivo pharmacokinetic profile was evaluated. When amorphous MTK particle was suspended in aqueous vehicle, it was readily converted into crystalline form and grown into aggregates, drastically lowering dissolution rate...
July 31, 2021: International Journal of Biological Macromolecules