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https://www.readbyqxmd.com/read/28915295/error-type-and-lexical-frequency-effects-error-detection-in-swedish-children-with-language-impairment
#1
Anna Eva Hallin, Christina Reuterskiöld
Purpose: The first aim of this study was to investigate if Swedish-speaking school-age children with language impairment (LI) show specific morphosyntactic vulnerabilities in error detection. The second aim was to investigate the effects of lexical frequency on error detection, an overlooked aspect of previous error detection studies. Method: Error sensitivity for grammatical structures vulnerable in Swedish-speaking preschool children with LI (omission of the indefinite article in a noun phrase with a neuter/common noun, and use of the infinitive instead of past-tense regular and irregular verbs) was compared to a control error (singular noun instead of plural)...
September 14, 2017: Journal of Speech, Language, and Hearing Research: JSLHR
https://www.readbyqxmd.com/read/28914904/probing-the-degenerate-states-of-v-point-singularities
#2
B S Bhargava Ram, Anurag Sharma, Paramasivam Senthilkumaran
V-points are polarization singularities in spatially varying linearly polarized optical fields and are characterized by the Poincare-Hopf index η. Each V-point singularity is a superposition of two oppositely signed orbital angular momentum states in two orthogonal spin angular momentum states. Hence, a V-point singularity has zero net angular momentum. V-points with given |η| have the same (amplitude) intensity distribution but have four degenerate polarization distributions. Each of these four degenerate states also produce identical diffraction patterns...
September 15, 2017: Optics Letters
https://www.readbyqxmd.com/read/28913561/conformational-rearrangement-of-1-2-d-gg-intrastrand-cis-diammineplatinum-crosslinked-dna-is-driven-by-counter-ion-penetration-within-the-minor-groove-of-the-modified-site
#3
Tsvetan G Gantchev, Peicho St Petkov, Darel J Hunting
The major structural aberrations of DNA induced by a cis-diammineplatinum (II) 1,2-d(GG) intrastrand cross-link (CPT) have been known for decades. To gain deeper insights into the structural dynamics of the sequence-dependent DNA distortions adjacent to the CPT adduct, we employed molecular modeling and molecular dynamics (MD) simulations. The structural dynamics of native (N-DNA) and cisPt 1,2-d(GG) crosslinked (CPT-DNA) in the form of symmetric 36 nt d(G2T15G*G*T15G2)●C2A15CCA15C2) oligonucleotide duplexes is compared...
September 14, 2017: Journal of Molecular Modeling
https://www.readbyqxmd.com/read/28912139/a-combination-rnai-chemotherapy-layer-by-layer-nanoparticle-for-systemic-targeting-of-kras-p53-with-cisplatin-to-treat-non-small-cell-lung-cancer
#4
Li Gu, Jason Z Deng, Sweta Roy, Paula T Hammond
PURPOSE: Mutation of the Kirsten ras sarcoma viral oncogene homolog (KRAS) and loss of p53 function are commonly seen in non-small cell lung cancer (NSCLC). Combining therapeutics targeting these tumor defensive pathways with cisplatin in a single nanoparticle platform are rarely developed in clinic. EXPERIMENTAL DESIGN: Cisplatin was encapsulated in liposomes which multiple polyelectrolyte layers including siKRAS and miR-34a were built on to generate multifunctional layer-by-layer nanoparticle...
September 14, 2017: Clinical Cancer Research: An Official Journal of the American Association for Cancer Research
https://www.readbyqxmd.com/read/28911848/detecting-weak-position-fluctuations-from-encoder-signal-using-singular-spectrum-analysis
#5
Xiaoqiang Xu, Ming Zhao, Jing Lin
Mechanical fault or defect will cause some weak fluctuations to the position signal. Detection of such fluctuations via encoders can help determine the health condition and performance of the machine, and offer a promising alternative to the vibration-based monitoring scheme. However, besides the interested fluctuations, encoder signal also contains a large trend and some measurement noise. In applications, the trend is normally several orders larger than the concerned fluctuations in magnitude, which makes it difficult to detect the weak fluctuations without signal distortion...
September 11, 2017: ISA Transactions
https://www.readbyqxmd.com/read/28910257/between-a-rock-and-a-hard-place-prescription-opioid-restrictions-in-the-time-of-fentanyl-and-other-street-drug-adulterants
#6
Tessa Cheng, Kora DeBeck
Non-medical prescription opioid use (NMPOU) has increased alarmingly across Canada and resulted in strict prescribing restrictions on opioids. Despite a clear need to reduce opioid prescriptions in response to this crisis, few other policies have been implemented and this singular focus is incongruent with the known characteristics of substance use disorders, negative effects of supply reduction policies, and realities of pain management. Given the recent rise of fentanyl and other dangerous adulterants in street drugs, this commentary argues that a comprehensive response to NMPOU that includes improvements to addiction management and harm-reduction services is urgently needed...
September 14, 2017: Canadian Journal of Public Health. Revue Canadienne de Santé Publique
https://www.readbyqxmd.com/read/28903626/light-dominates-peripheral-circadian-oscillations-in-drosophila-melanogaster-during-sensory-conflict
#7
Ross E F Harper, Maite Ogueta, Peter Dayan, Ralf Stanewsky, Joerg T Albert
In Drosophila, as in other animals, the circadian clock is a singular entity in name and concept only. In reality, clock functions emerge from multiple processes and anatomical substrates. One distinction has conventionally been made between a central clock (in the brain) and peripheral clocks (e.g., in the gut and the eyes). Both types of clock generate robust circadian oscillations, which do not require external input. Furthermore, the phases of these oscillations remain exquisitely sensitive to specific environmental cues, such as the daily changes of light and temperature...
September 1, 2017: Journal of Biological Rhythms
https://www.readbyqxmd.com/read/28902997/coupled-cluster-in-real-space-i-cc2-ground-state-energies-using-multi-resolution-analysis
#8
Jakob Siegfried Kottmann, Florian Andreas Bischoff
A framework to calculate approximate coupled-cluster CC2 ground-state correlation energies in a multiresolution basis is derived and implemented into the MADNESS library. The CC2 working equations are rederived in first quantization which makes them suitable for real-space methods. The first-quantized equations can be interpreted diagrammatically using the usual diagrams from second quantization with adjusted interpretation rules. Singularities arising form the nuclear and electronic potentials are regularized by explicitly taking the nuclear and electronic cusps into account...
September 13, 2017: Journal of Chemical Theory and Computation
https://www.readbyqxmd.com/read/28901698/online-training-introduces-a-novel-approach-to-the-dietetic-care-process-documentation
#9
Shelly Rachman-Elbaum, Aliza H Stark, Josefa Kachal, Teresa Johnson, Bat Sheva Porat-Katz
AIM: Nutrition professionals in Israel are developing a system to document the Dietetic Care Process (DCP) tailored for specific patient sectors and compliant with national health guidelines. The ultimate goal is to achieve uniform documentation and improve nutrition care. Israeli dietetic practitioners work in specific patient sectors; therefore, a patient population-specific reporting system is proposed instead of the typical singular format applied across all patient populations. The purpose of this project was to evaluate learning outcomes and attitudes among registered dietitians (RDs) after online training of a novel DCP documentation system...
September 2017: Nutrition & Dietetics: the Journal of the Dietitians Association of Australia
https://www.readbyqxmd.com/read/28900571/cavitation-sounds-during-cervicothoracic-spinal-manipulation
#10
James Dunning, Firas Mourad, Andrea Zingoni, Raffaele Iorio, Thomas Perreault, Noah Zacharko, César Fernández de Las Peñas, Raymond Butts, Joshua A Cleland
BACKGROUND: No study has previously investigated the side, duration or number of audible cavitation sounds during high-velocity low-amplitude (HVLA) thrust manipulation to the cervicothoracic spine. PURPOSE: The primary purpose was to determine which side of the spine cavitates during cervicothoracic junction (CTJ) HVLA thrust manipulation. Secondary aims were to calculate the average number of cavitations, the duration of cervicothoracic thrust manipulation, and the duration of a single cavitation...
August 2017: International Journal of Sports Physical Therapy
https://www.readbyqxmd.com/read/28900400/fractional-stability-of-trunk-acceleration-dynamics-of-daily-life-walking-toward-a-unified-concept-of-gait-stability
#11
Espen A F Ihlen, Kimberley S van Schooten, Sjoerd M Bruijn, Mirjam Pijnappels, Jaap H van Dieën
Over the last decades, various measures have been introduced to assess stability during walking. All of these measures assume that gait stability may be equated with exponential stability, where dynamic stability is quantified by a Floquet multiplier or Lyapunov exponent. These specific constructs of dynamic stability assume that the gait dynamics are time independent and without phase transitions. In this case the temporal change in distance, d(t), between neighboring trajectories in state space is assumed to be an exponential function of time...
2017: Frontiers in Physiology
https://www.readbyqxmd.com/read/28900137/tailoring-eigenmodes-at-spectral-singularities-in-graphene-based-pt-systems
#12
Weixuan Zhang, Tong Wu, Xiangdong Zhang
The spectral singularity existing in PT-synthetic plasmonic system has been widely investigated. Only lasing-mode can be excited resulting from the passive characteristic of metallic materials. Here, we investigated the spectral singularity in the hybrid structure composed of the photoexcited graphene and one-dimensional PT-diffractive grating. In this system, both lasing- and absorption-modes can be excited with the surface conductivity of photoexcited graphene being loss and gain, respectively. Remarkably, the spectral singularity will disappear with the optically pumped graphene to be lossless...
September 12, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28899429/amyloid-independent-atrophy-patterns-predict-time-to-progression-to-dementia-in-mild-cognitive-impairment
#13
Mara Ten Kate, Frederik Barkhof, Pieter Jelle Visser, Charlotte E Teunissen, Philip Scheltens, Wiesje M van der Flier, Betty M Tijms
BACKGROUND: Amyloid pathology in subjects with mild cognitive impairment (MCI) is an important risk factor for progression to dementia due to Alzheimer's disease. Predicting the onset of dementia is challenging even in the presence of amyloid, as time to progression varies considerably among patients and depends on the onset of neurodegeneration. Survival analysis can account for variability in time to event, but has not often been applied to MRI measurements beyond singular predefined brain regions such as the hippocampus...
September 12, 2017: Alzheimer's Research & Therapy
https://www.readbyqxmd.com/read/28899281/the-value-of-developing-a-mixed-methods-program-of-research
#14
Shannon Simonovich
This article contributes to the discussion of the value of utilizing mixed methodological approaches to conduct nursing research. To this end, the author of this article proposes creating a mixed-methods program of research over time, where both quantitative and qualitative data are collected and analyzed simultaneously, rather than focusing efforts on designing singular mixed-methods studies. A mixed-methods program of research would allow for the best of both worlds: precision through focus on one method at a time, and the benefits of creating a robust understanding of a phenomenon over the trajectory of one's career through examination from various methodological approaches...
July 2017: Nursing Science Quarterly
https://www.readbyqxmd.com/read/28895611/velocity-amplification-in-pressure-driven-flows-between-superhydrophobic-gratings-of-small-solid-fraction
#15
Ehud Yariv
With diminishing fraction of their solid portion, compound gas-solid superhydrophobic surfaces exhibit a large amount of slip which allows for appreciable velocity amplification in pressure-driven microchannel flows. We address this small solid-fraction limit in the context of a grating-like configuration, where superhydrophobicity is provided by a periodic array of flat-meniscus bubbles which are trapped in a Cassie state within the grooved channel walls. Asymptotic analysis for both longitudinal and transverse flows reveals a logarithmic scaling of the effective slip length in the solid fraction of the compound boundaries, thus refuting earlier claims of an algebraic singularity...
September 12, 2017: Soft Matter
https://www.readbyqxmd.com/read/28895283/right-ventricle-outflow-tract-prestenting-in-vitro-testing-of-rigidity-and-corrosion-properties
#16
Bjorn Cools, Stephen Brown, Martine Wevers, Jan Van Humbeeck, Derize Boshoff, Cis Verdonckt, Marc Gewillig
BACKGROUND: The aim of this study was to assess the resistance to compression (stiffness) of frequently used stents for right ventricular outflow tract prestenting. In addition, to assess the corrosion potential when different types of stent alloys come into contact with each other. METHOD: Different stents were tested in vitro in various combinations at specialized metallurgic laboratories. A bench compression test was used to assess resistance to compression of singular and joined combinations of stents...
September 12, 2017: Catheterization and Cardiovascular Interventions
https://www.readbyqxmd.com/read/28893622/differential-expression-of-vitamin-d-associated-enzymes-and-receptors-in-brain-cell-subtypes
#17
Véréna Landel, Delphine Stephan, Xiaoying Cui, Darryl Eyles, François Feron
Accumulating evidence indicates that the active form of vitamin D, 1,25(OH)2D3, can be considered as a neurosteroid. However, the cerebral expression of vitamin D-associated enzymes and receptors remains controversial. With the idea of carrying out a comparative study in mind, we compared the transcript expression of Cyp27a1, Cyp27b1, Cyp24a1, Vdr and Pdia3 in purified cultures of astrocytes, endothelial cells, microglia, neurons and oligodendrocytes. We observed that endothelial cells and neurons can possibly transform the inactive cholecalciferol into 25(OH)D3...
September 8, 2017: Journal of Steroid Biochemistry and Molecular Biology
https://www.readbyqxmd.com/read/28891636/cuaac-based-click-chemistry-in-self-healing-polymers
#18
Diana Döhler, Philipp Michael, Wolfgang H Binder
Click chemistry has emerged as a significant tool for materials science, organic chemistry, and bioscience. Based on the initial concept of Barry Sharpless in 2001, the copper(I)-catalyzed azide/alkyne cycloaddition (CuAAC) reaction has triggered a plethora of chemical concepts for linking molecules and building blocks under ambient conditions, forming the basis for applications in autonomous cross-linking materials. Self-healing systems on the other hand are often based on mild cross-linking chemistries that are able to react either autonomously or upon an external trigger...
September 11, 2017: Accounts of Chemical Research
https://www.readbyqxmd.com/read/28890964/utilization-of-the-dye-n-methyl-6-oxyquinolone-as-an-optical-acidometer-in-molecular-solvents-and-protic-ionic-liquids
#19
Stella Schmode, Ralf Ludwig
We developed a procedure to use the highly sensitive dye N-methyl-6-oxyquinolone as an acidity probe in molecular solvents and protic ionic liquids. The combination of well-established stationary UV-vis absorption and the mathematical algorithm of singular value decomposition allows the determination of the amount of acidic protons even in complex solvents like ionic liquids.
September 11, 2017: Chemical Communications: Chem Comm
https://www.readbyqxmd.com/read/28890665/trends-and-events-through-seven-centuries-the-history-of-a-wetland-landscape-in-the-czech-republic
#20
Péter Szabó, Andrea Gálová, Eva Jamrichová, Kateřina Šumberová, Jan Šipoš, Radim Hédl
Environmental change can be viewed as the combined result of long-term processes and singular events. While long-term trends appear to be readily available for observation (in the form of temporal comparisons or space-for-time substitution), it is more difficult to gain information on singular events in the past, although these can be equally significant in shaping ecosystems. We examined the past 700 years in the history of a lowland wetland landscape in the Czech Republic with the help of palaeoecological, ecological, landscape archaeological, and archival data...
February 2017: Regional Environmental Change
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