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https://www.readbyqxmd.com/read/27913823/mathematical-models-suggest-facilitated-fatty-acids-crossing-of-the-luminal-membrane-in-the-cardiac-muscle
#1
Efrath Barta
Long-chain fatty acids cross a few membranes on their way from the capillary blood to the cardiomyocyte cytosol, where they are utilized as an essential source of energy. Details of the transport mechanism across those membranes remained elusive despite decades of laboratory and theoretical work. Here we inspect several optional scenarios for the crossing of the luminal membrane of the endothelial cell, the first barrier that should be crossed: a passive diffusion, facilitation by receptors for albumin and facilitation by fatty acids transporters...
December 3, 2016: Journal of Membrane Biology
https://www.readbyqxmd.com/read/27912050/francis-crick-a-singular-approach-to-scientific-discovery
#2
Peter A Lawrence
Francis' office window (at the Salk) commanded a panorama of the Pacific. "This grand natural scene was a physical correlate of Francis's intellectual world: wide-ranging, brilliantly lit, a little overawing, but also immensely inviting and above all an exciting place to be." (Mitchison, 2004).
December 1, 2016: Cell
https://www.readbyqxmd.com/read/27911557/bifurcations-and-singularities-for-coupled-oscillators-with-inertia-and-frustration
#3
J Barré, D Métivier
We prove that any nonzero inertia, however small, is able to change the nature of the synchronization transition in Kuramoto-like models, either from continuous to discontinuous or from discontinuous to continuous. This result is obtained through an unstable manifold expansion in the spirit of Crawford, which features singularities in the vicinity of the bifurcation. Far from being unwanted artifacts, these singularities actually control the qualitative behavior of the system. Our numerical tests fully support this picture...
November 18, 2016: Physical Review Letters
https://www.readbyqxmd.com/read/27910915/locating-the-quantum-critical-point-of-the-bose-hubbard-model-through-singularities-of-simple-observables
#4
Mateusz Łącki, Bogdan Damski, Jakub Zakrzewski
We show that the critical point of the two-dimensional Bose-Hubbard model can be easily found through studies of either on-site atom number fluctuations or the nearest-neighbor two-point correlation function (the expectation value of the tunnelling operator). Our strategy to locate the critical point is based on the observation that the derivatives of these observables with respect to the parameter that drives the superfluid-Mott insulator transition are singular at the critical point in the thermodynamic limit...
December 2, 2016: Scientific Reports
https://www.readbyqxmd.com/read/27910137/amelanotic-naevoid-melanoma-in-a-16-month-old-albino-infant
#5
N Knöpfel, A Martín-Santiago, L J Del Pozo, C Saus, M Pascual, L Requena
Melanoma in individuals with oculocutaneous albinism has been reported in the literature to be rare compared with the more common occurrence of squamous cell carcinoma and basal cell carcinoma. We present a singular case of amelanotic naevoid melanoma arising from a small congenital naevus in a 16-month old albino boy, the youngest reported to date.
December 2, 2016: Clinical and Experimental Dermatology
https://www.readbyqxmd.com/read/27909398/an-amyloid-like-pathological-conformation-of-tdp-43-is-stabilized-by-hypercooperative-hydrogen-bonds
#6
Miguel Mompeán, Marco Baralle, Emanuele Buratti, Douglas V Laurents
TDP-43 is an essential RNA-binding protein forming aggregates in almost all cases of sporadic amyotrophic lateral sclerosis (ALS) and many cases of frontotemporal lobar dementia (FTLD) and other neurodegenerative diseases. TDP-43 consists of a folded N-terminal domain with a singular structure, two RRM RNA-binding domains, and a long disordered C-terminal region which plays roles in functional RNA regulatory assemblies as well as pernicious aggregation. Evidence from pathological mutations and seeding experiments strongly suggest that TDP-43 aggregates are pathologically relevant through toxic gain-of-harmful-function and/or harmful loss-of-native-function mechanisms...
2016: Frontiers in Molecular Neuroscience
https://www.readbyqxmd.com/read/27908663/communal-nesting-in-the-garden-dormouse-eliomys-quercinus
#7
Adrià Viñals, Sandro Bertolino, José Antonio Gil-Delgado
Communal nesting has been described in many rodents including some dormouse species. In this study, we report the existence of this reproductive strategy in the garden dormouse Eliomys quercinus. Data was recorded by checking natural nests and nest-boxes from 2003 to 2013 in SE Spain. Pups and adults dormice found in nests were captured and marked. Overall, 198 nests were found: 161 (81.31%) were singular nests and 37 (18.69%) were communal nests. Communal nests were composed by different combinations of one up to three females together with one up to three different size litters...
November 28, 2016: Behavioural Processes
https://www.readbyqxmd.com/read/27908185/a-comparison-of-linear-interpolation-models-for-iterative-ct-reconstruction
#8
Katharina Hahn, Harald Schöndube, Karl Stierstorfer, Joachim Hornegger, Frédéric Noo
PURPOSE: Recent reports indicate that model-based iterative reconstruction methods may improve image quality in computed tomography (CT). One difficulty with these methods is the number of options available to implement them, including the selection of the forward projection model and the penalty term. Currently, the literature is fairly scarce in terms of guidance regarding this selection step, whereas these options impact image quality. Here, the authors investigate the merits of three forward projection models that rely on linear interpolation: the distance-driven method, Joseph's method, and the bilinear method...
December 2016: Medical Physics
https://www.readbyqxmd.com/read/27908003/resonance-phenomena-in-a-two-layer-two-vortex-shear-flow
#9
Eugene A Ryzhov, Konstantin V Koshel
The paper deals with a dynamical system governing the motion of two point vortices embedded in the bottom layer of a two-layer rotating flow experiencing linear deformation and their influence on fluid particle advection. The linear deformation consists of shear and rotational components. If the deformation is stationary, the vortices can move periodically in a bounded region. The vortex periodic motion induces stirring patterns of passive fluid particles in the both layers. We focus our attention on the upper layer where the bottom-layer singular point vortices induce a regular velocity field with no singularities...
November 2016: Chaos
https://www.readbyqxmd.com/read/27907144/a-new-efficient-method-for-detecting-phase-singularity-in-cardiac-fibrillation
#10
Young-Seon Lee, Jun-Seop Song, Minki Hwang, Byounghyun Lim, Boyoung Joung, Hui-Nam Pak
BACKGROUND: The point of phase singularity (PS) is considered to represent a spiral wave core or a rotor in cardiac fibrillation. Computational efficiency is important for detection of PS in clinical electrophysiology. We developed a novel algorithm for highly efficient and robust detection of PS. METHODS: In contrast to the conventional method, which calculates PS based on the line integral of the phase around a PS point equal to ±2π (the Iyer-Gray method), the proposed algorithm (the location-centric method) looks for the phase discontinuity point at which PS actually occurs...
2016: PloS One
https://www.readbyqxmd.com/read/27906655/methodology-considerations-in-phase-mapping-of-human-cardiac-arrhythmias
#11
Ramya Vijayakumar, Sunil K Vasireddi, Phillip S Cuculich, Mitchell N Faddis, Yoram Rudy
BACKGROUND: Phase analysis of cardiac arrhythmias, particularly atrial fibrillation, has gained interest because of the ability to detect organized stable drivers (rotors) and target them for therapy. However, the lack of methodology details in publications on the topic has resulted in ongoing debate over the phase mapping technique. By comparing phase maps and activation maps, we examined advantages and limitations of phase mapping. METHODS AND RESULTS: Seven subjects were enrolled...
November 2016: Circulation. Arrhythmia and Electrophysiology
https://www.readbyqxmd.com/read/27906367/cultivation-of-lemon-fields
#12
Sushanta Kumar Pal, P Senthilkumaran
The sign rule requires that adjacent singularities on a contour have opposite signs and hence cultivation of lemon only fields poses problem as all lemons have positive index. In this paper we show that the interference of three linearly polarized plane waves can create regions of ellipse and vector fields in 2-dimensions (2D) in which a lemon lattice is interlaced in a V-point lattice. The lemons appear at intensity maxima of the lattice structure while the V-points take care of index conservation by sitting at intensity minima...
November 28, 2016: Optics Express
https://www.readbyqxmd.com/read/27903901/core-binding-factor-cbf-is-required-for-epstein-barr-virus-ebna3-proteins-to-regulate-target-gene-expression
#13
Kostas Paschos, Quentin Bazot, Guiyi Ho, Gillian A Parker, Jonathan Lees, Geraint Barton, Martin J Allday
ChIP-seq performed on lymphoblastoid cell lines (LCLs), expressing epitope-tagged EBNA3A, EBNA3B or EBNA3C from EBV-recombinants, revealed important principles of EBNA3 binding to chromatin. When combined with global chromatin looping data, EBNA3-bound loci were found to have a singular character, each directly associating with either EBNA3-repressed or EBNA3-activated genes, but not with both. EBNA3A and EBNA3C showed significant association with repressed and activated genes. Significant direct association for EBNA3B loci could only be shown with EBNA3B-repressed genes...
November 29, 2016: Nucleic Acids Research
https://www.readbyqxmd.com/read/27902322/proposal-to-modify-rule-12c-of-the-international-code-of-nomenclature-of-prokaryotes
#14
Aharon Oren
According to the current version of Rule 12c of the International Code of Nomenclature of Prokaryotes, one of the ways in which a specific epithet can be treated is as an adjective that must agree in gender with the generic name. I propose emending this part of Rule 12c to specify that such adjectives must be in the singular form in the nominative case.
November 30, 2016: International Journal of Systematic and Evolutionary Microbiology
https://www.readbyqxmd.com/read/27902227/streptococcus-himalayensis-sp-nov-a-new-streptococcal-species-isolated-from-the-respiratory-tract-of-marmota-himalayana-in-qinghai-tibet-plateau-of-china
#15
Lina Niu, Shan Lu, Xin-He Lai, Shoukui Hu, Cuixia Chen, Gui Zhang, Jing Yang, Dong Jin, Yi Wang, Ruiting Lan, Gang Lu, Yingping Xie, Changyun Ye, Jianguo Xu
Five strains of Gram-positive staining, catalase-negative, coccus-shaped chain-forming organisms separately isolated from the respiratory tracts of 5 Marmota himalayana animals in the Qinghai-Tibet Plateau of China were subjected to phenotypic and molecular taxonomic analyses. Comparative analysis of the 16S rRNA gene indicated that these singular organisms represent a new member of the genus Streptococcus, being phylogenetically closest to Streptococcus marmotae DSM101995T (98.4% similarity). The groEL, sodA and rpoB sequence analysis showed interspecies similarity values between HTS2T and Streptococcus marmotae DSM101995T, its closest 16S rRNA phylogenetic relative, of 98...
October 25, 2016: International Journal of Systematic and Evolutionary Microbiology
https://www.readbyqxmd.com/read/27900145/the-sensitivity-and-specificity-of-clinical-measures-of-sport-concussion-three-tests-are-better-than-one
#16
Jacob E Resch, Cathleen N Brown, Julianne Schmidt, Stephen N Macciocchi, Damond Blueitt, C Munro Cullum, Michael S Ferrara
CONTEXT: A battery of clinical measures of neurocognition, balance and symptoms has been recommended for the management of sport concussion (SC) but is based on variable evidence. OBJECTIVE: To examine the sensitivity and specificity of a battery of tests to assess SC in college athletes. DESIGN: Cross-sectional. SETTING: Research laboratory. PATIENTS OR OTHER PARTICIPANTS: Division 1 athletes diagnosed with a SC (n=40) who were 20...
2016: BMJ Open Sport & Exercise Medicine
https://www.readbyqxmd.com/read/27898798/visualization-of-colloid-transport-pathways-in-mineral-soils-using-titanium-iv-oxide-as-a-tracer
#17
Stefan Koch, Petra Kahle, Bernd Lennartz
In soils, colloidal transport has been identified as the most important pathway for strong adsorbing, environmental contaminants like pesticides, heavy metals, and phosphorus. We conducted a comparative dye tracer experiment using a Brilliant Blue (BB) solution and a Titanium(IV) oxide (TiO) colloid suspension (average particle size 0.3 μm), aiming to visualize and quantify colloid pathways in soils. Both dye tracers showed comparable general flow patterns with preferred transport over the deepest part of the soil profile, independent of clay content...
November 2016: Journal of Environmental Quality
https://www.readbyqxmd.com/read/27898342/voice-sensitive-brain-networks-encode-talker-specific-phonetic-detail
#18
Emily B Myers, Rachel M Theodore
The speech stream simultaneously carries information about talker identity and linguistic content, and the same acoustic property (e.g., voice-onset-time, or VOT) may be used for both purposes. Separable neural networks for processing talker identity and phonetic content have been identified, but it is unclear how a singular acoustic property is parsed by the neural system for talker identification versus phonetic processing. In the current study, listeners were exposed to two talkers with characteristically different VOTs...
November 26, 2016: Brain and Language
https://www.readbyqxmd.com/read/27895580/increased-levels-of-mirna-146a-in-serum-and-histologic-samples-of-patients-with-uveal-melanoma
#19
Andrea Russo, Rosario Caltabiano, Antonio Longo, Teresio Avitabile, Livio M Franco, Vincenza Bonfiglio, Lidia Puzzo, Michele Reibaldi
Purpose: To analyze MiRs expression in serum of UM patients, respect to healthy donors, and to compare this data with MiRs expressed in formalin-fixed, paraffin-embedded UM samples. Methods: Expression profile of 754 miRNAs was performed in serum of patients with uveal melanoma who underwent primary enucleation. The level of miRNAs increased in serum was individually analyzed on FFPE UM samples and compared to choroidal melanocytes from unaffected eyes. Results: Fourteen patients with uveal melanoma were included in the study...
2016: Frontiers in Pharmacology
https://www.readbyqxmd.com/read/27893440/a-3d-reconstruction-algorithm-for-magneto-acoustic-tomography-with-magnetic-induction-based-on-ultrasound-transducer-characteristics
#20
Ren Ma, Xiaoqing Zhou, Shunqi Zhang, Tao Yin, Zhipeng Liu
In this study we present a three-dimensional (3D) reconstruction algorithm for magneto-acoustic tomography with magnetic induction (MAT-MI) based on the characteristics of the ultrasound transducer. The algorithm is investigated to solve the blur problem of the MAT-MI acoustic source image, which is caused by the ultrasound transducer and the scanning geometry. First, we established a transducer model matrix using measured data from the real transducer. With reference to the S-L model used in the computed tomography algorithm, a 3D phantom model of electrical conductivity is set up...
December 21, 2016: Physics in Medicine and Biology
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