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https://www.readbyqxmd.com/read/28636040/tamoxifen-like-metallocifens-target-the-thioredoxin-system-determining-mitochondrial-impairment-leading-to-apoptosis-in-jurkat-cells
#1
Valeria Scalcon, Michèle Salmain, Alessandra Folda, Siden Top, Pascal Pigeon, Hui Zhi Shirley Lee, Gérard Jaouen, Alberto Bindoli, Anne Vessières, Maria Pia Rigobello
Tamoxifen-like metallocifens (TLMs) of the group-8 metals (Fe, Ru, and Os) show strong anti-proliferative activity on cancer cell lines resistant to apoptosis, owing to their unique redox properties. In contrast, the thioredoxin system, which is involved in cellular redox balance, is often overexpressed in cancer cells, especially in tumour types resistant to standard chemotherapies. Therefore, we investigated the effect of these three TLMs on the thioredoxin system and evaluated the input of the metallocene unit in comparison with structurally related organic tamoxifens...
June 21, 2017: Metallomics: Integrated Biometal Science
https://www.readbyqxmd.com/read/28633631/knowledge-of-antibiotic-resistance-and-antibiotic-prescription-practices-among-prescribers-in-the-brong-ahafo-region-of-ghana-a-cross-sectional-study
#2
Kwaku Poku Asante, Ellen Abrafi Boamah, Martha Ali Abdulai, Kwame Ohene Buabeng, Emmanuel Mahama, Francis Dzabeng, Edith Gavor, Edith Andrews Annan, Seth Owusu-Agyei, Martha Gyansa-Lutterodt
BACKGROUND: Antibiotic resistance (ABR) has become a major public health challenge in most parts of the world including Ghana and is a major threat to gain in bacterial disease control. The role of prescribers in the control of antibiotics is identified as crucial in developing interventions to control ABR. To guide policy recommendations on ABR, a study was carried out among prescribers to identify gaps in their knowledge of ABR and to document their prescription practices. METHOD: A cross-sectional survey was conducted among prescribers from both public and private facilities in the Brong Ahafo Region of Ghana using both quantitative and qualitative methods in 2014...
June 20, 2017: BMC Health Services Research
https://www.readbyqxmd.com/read/28632057/rotation-sequence-to-report-humerothoracic-kinematics-during-3d-motion-involving-large-horizontal-component-application-to-the-tennis-forehand-drive
#3
Thomas Creveaux, Violaine Sevrez, Raphaël Dumas, Laurence Chèze, Isabelle Rogowski
The aim of this study was to examine the respective aptitudes of three rotation sequences (YtXf'Yh'', ZtXf'Yh'', and XtZf'Yh'') to effectively describe the orientation of the humerus relative to the thorax during a movement involving a large horizontal abduction/adduction component: the tennis forehand drive. An optoelectronic system was used to record the movements of eight elite male players, each performing ten forehand drives. The occurrences of gimbal lock, phase angle discontinuity and incoherency in the time course of the three angles defining humerothoracic rotation were examined for each rotation sequence...
February 28, 2017: Sports Biomechanics
https://www.readbyqxmd.com/read/28631042/dispersal-towards-food-the-singular-limit-of-an-allen-cahn-equation
#4
Danielle Hilhorst, Yong-Jung Kim, Dohyun Kwon, Thanh Nam Nguyen
The effect of dispersal under heterogeneous environment is studied in terms of the singular limit of an Allen-Cahn equation. Since biological organisms often slow down their dispersal if food is abundant, a food metric diffusion is taken to include such a phenomenon. The migration effect of the problem is approximated by a mean curvature flow after taking the singular limit which now includes an advection term produced by the spatial heterogeneity of food distribution. It is shown that the interface moves towards a local maximum of the food distribution...
June 19, 2017: Journal of Mathematical Biology
https://www.readbyqxmd.com/read/28630655/neural-patterns-elicited-by-sentence-processing-uniquely-characterize-typical-development-sli-recovery-and-sli-persistence
#5
Eileen Haebig, Christine Weber, Laurence B Leonard, Patricia Deevy, J Bruce Tomblin
BACKGROUND: A substantial amount of work has examined language abilities in young children with specific language impairment (SLI); however, our understanding of the developmental trajectory of language impairment is limited. Along with studying the behavioral changes that occur across development, it is important to examine the neural indices of language processing for children with different language trajectories. The current study sought to examine behavioral and neural bases of language processing in adolescents showing three different trajectories: those with normal language development (NL), those exhibiting persistent SLI (SLI-Persistent), and those with a history of SLI who appear to have recovered (SLI-Recovered)...
2017: Journal of Neurodevelopmental Disorders
https://www.readbyqxmd.com/read/28629518/analysis-of-the-asymmetry-of-activated-epo-receptor-enables-designing-small-molecule-agonists
#6
Frank Guarnieri
Amgen solved the high-resolution cocrystal structure of erythropoietin (EPO) bound to the extracellular part of the receptor (EPOR) in 1998, which reveals that the EPO-EPOR interaction surface is formed by 11 salt bridges, 17 H-bonds, and 2 hydrophobic clusters centered at a pair of crucial phenylalanines (F93). The EPOR has two domains, one that penetrates the membrane and a second extracellular domain that forms one arm of the binding site for the EPO ligand. The complete competent receptor-binding site is a homodimer of EPOR with the two arms forming a funnel-shaped cup where EPO binds...
2017: Vitamins and Hormones
https://www.readbyqxmd.com/read/28629494/shewanella-intestini-sp-nov-isolated-from-the-intestine-of-abalone-haliotis-diversicolor
#7
Yingbao Gai, Zhaobin Huang, Qiliang Lai, Zongze Shao
A Gram-stain-negative, rod-shaped bacterium with a singular polar flagellum, designated as strain XMDDZSB0408T, was isolated from the intestine of adult abalone, Haliotis diversicolor. Activity of oxidase was positive and catalase activity was negative. It could grow at salinities from 3 to 6 % NaCl (w/v), and pH 7-9. It had the highest sequence similarity of <96.0 % with all previously established species for the complete 16S rRNA gene (1531 bp). The results of phylogenetic analysis indicated that the strain was affiliated to the genus Shewanella and closely related to Shewanella gaetbuli TF-27T and Shewanella japonica KMM 3299T (95...
June 20, 2017: International Journal of Systematic and Evolutionary Microbiology
https://www.readbyqxmd.com/read/28629423/understanding-consumer-and-clinician-preferences-and-decision-making-for-rehabilitation-following-arthroplasty-in-the-private-sector
#8
Mark A Buhagiar, Justine M Naylor, Grahame Simpson, Ian A Harris, Friedbert Kohler
BACKGROUND: To understand private consumer and clinician preferences towards different rehabilitation modes following knee or hip arthroplasty, and identify factors which influence the chosen rehabilitation pathway. METHODS: Mixed methods cross-sectional study involving 95 semi-structured interviews of consumers (patients and carers) and clinicians (arthroplasty surgeons, physiotherapists and rehabilitation physicians) in Sydney, Australia, during 2014-2015. Participants were asked about the acceptability of different modes of rehabilitation provision, and factors influencing their chosen rehabilitation pathway...
June 19, 2017: BMC Health Services Research
https://www.readbyqxmd.com/read/28627878/tilted-two-dimensional-array-multi-focus-confocal-raman-microspectroscopy
#9
Sohshi Yabumoto, Hiro-O Hamaguchi
A simple and efficient two-dimensional multi-focus confocal Raman microspectroscopy featuring the tilted-array technique is demonstrated. Raman scattering from a 4×4 square foci array passing through a 4×4 confocal pinhole array is tilted with a periscope. The tilted array of Raman scattering signals is dispersed by an imaging spectrograph onto a CCD detector, giving 16 independent Raman spectra formed as 16 bands with different heights on the sensor. Use of a state-of-the-art imaging spectrograph enables high-precision wavenumber duplicability of the 16 spectra...
June 19, 2017: Analytical Chemistry
https://www.readbyqxmd.com/read/28626470/multi-infarct-dementia-a-historical-perspective
#10
REVIEW
Erin McKay, Scott E Counts
BACKGROUND: Multi-infarct dementia (MID), a prominent subtype of vascular dementia (VaD), has only achieved recognition in the last 4 decades. Since its original description, the characterization, etiological understanding, and therapeutic direction of MID and other VaD subtypes has progressed at an astounding rate. SUMMARY: This paper divides the landmark discoveries and emergence of new research strategies for MID into decade-defining patterns so that a condensed picture of the total history of MID and its eventual inclusion as a VaD subtype emerges...
January 2017: Dementia and Geriatric Cognitive Disorders Extra
https://www.readbyqxmd.com/read/28626275/phylogeny-of-saprobic-microfungi-from-southern-europe
#11
M Hernández-Restrepo, J Gené, R F Castañeda-Ruiz, J Mena-Portales, P W Crous, J Guarro
During a survey of saprophytic microfungi on decomposing woody, herbaceous debris and soil from different regions in Southern Europe, a wide range of interesting species of asexual ascomycetes were found. Phylogenetic analyses based on partial gene sequences of SSU, LSU and ITS proved that most of these fungi were related to Sordariomycetes and Dothideomycetes and to lesser extent to Leotiomycetes and Eurotiomycetes. Four new monotypic orders with their respective families are proposed here, i.e. Lauriomycetales, Lauriomycetaceae; Parasympodiellales, Parasympodiellaceae; Vermiculariopsiellales, Vermiculariopsiellaceae and Xenospadicoidales, Xenospadicoidaceae...
March 2017: Studies in Mycology
https://www.readbyqxmd.com/read/28624712/classification-of-ecg-heartbeats-using-nonlinear-decomposition-methods-and-support-vector-machine
#12
Kandala N V P S Rajesh, Ravindra Dhuli
Classifying electrocardiogram (ECG) heartbeats for arrhythmic risk prediction is a challenging task due to minute variations in the amplitude, duration and morphology of the ECG signal. In this paper, we propose two feature extraction approaches to classify five types of heartbeats: normal, premature ventricular contraction, atrial premature contraction, left bundle branch block and right bundle branch block. In the first approach, ECG beats are decomposed into intrinsic mode functions (IMFs) using ensemble empirical mode decomposition (EEMD)...
June 15, 2017: Computers in Biology and Medicine
https://www.readbyqxmd.com/read/28624001/diagnosis-and-management-of-the-venous-malformations-of-klippel-tr%C3%A3-naunay-syndrome
#13
REVIEW
S Keisin Wang, Natalie A Drucker, Alok K Gupta, Francis E Marshalleck, Michael C Dalsing
OBJECTIVE: A dearth of information exists in the literature regarding current practice in the management of Klippel-Trénaunay syndrome (KTS), a rare condition. We review and describe the etiology, diagnosis, and treatment of KTS. METHODS: Relevant data were synthesized from a Medline review using a combination of the keyterms "Klippel" and "Trénaunay." The majority of hits described singular case reports and were subsequently excluded. The remaining papers were then reviewed and included on the basis of the quality of evidence and the authors' discretion...
July 2017: Journal of Vascular Surgery. Venous and Lymphatic Disorders
https://www.readbyqxmd.com/read/28623610/a-singular-role-of-ik1-promoting-the-development-of-cardiac-automaticity-during-cardiomyocyte-differentiation-by-ik1-induced-activation-of-pacemaker-current
#14
Yu Sun, Valeriy Timofeyev, Adrienne Dennis, Emre Bektik, Xiaoping Wan, Kenneth R Laurita, Isabelle Deschênes, Ronald A Li, Ji-Dong Fu
The inward rectifier potassium current (IK1) is generally thought to suppress cardiac automaticity by hyperpolarizing membrane potential (MP). We recently observed that IK1 could promote the spontaneously-firing automaticity induced by upregulation of pacemaker funny current (If) in adult ventricular cardiomyocytes (CMs). However, the intriguing ability of IK1 to activate If and thereby promote automaticity has not been explored. In this study, we combined mathematical and experimental assays and found that only IK1 and If, at a proper-ratio of densities, were sufficient to generate rhythmic MP-oscillations even in unexcitable cells (i...
June 16, 2017: Stem Cell Reviews
https://www.readbyqxmd.com/read/28622002/direct-photon-production-at-next-to-next-to-leading-order
#15
John M Campbell, R Keith Ellis, Ciaran Williams
We present the first calculation of direct photon production at next-to-next-to-leading order (NNLO) accuracy in QCD. For this process, although the final-state cuts mandate only the presence of a single electroweak boson, the underlying kinematics resembles that of a generic vector boson plus jet topology. In order to regulate the infrared singularities present at this order, we use the N-jettiness slicing procedure, applied for the first time to a final state that at the Born level includes colored partons but no required jet...
June 2, 2017: Physical Review Letters
https://www.readbyqxmd.com/read/28619477/a-novel-body-frame-based-approach-to-aerospacecraft-attitude-tracking
#16
Carlos Ma, Michael Z Q Chen, James Lam, Kie Chung Cheung
In the common practice of designing an attitude tracker for an aerospacecraft, one transforms the Newton-Euler rotation equations to obtain the dynamic equations of some chosen inertial frame based attitude metrics, such as Euler angles and unit quaternions. A Lyapunov approach is then used to design a controller which ensures asymptotic convergence of the attitude to the desired orientation. Although this design methodology is pretty standard, it usually involves singularity-prone coordinate transformations which complicates the analysis process and controller design...
June 12, 2017: ISA Transactions
https://www.readbyqxmd.com/read/28619308/what-the-public-think-about-hypnosis-and-hypnotherapy-a-narrative-review-of-literature-covering-opinions-and-attitudes-of-the-general-public-1996-2016
#17
REVIEW
Matthew Krouwel, Kate Jolly, Sheila Greenfield
OBJECTIVES: To describe the public's understanding of hypnosis and openness to hypnotherapy. METHODS: A comprehensive search of English language peer reviewed journal articles from 1st January 1996-11th March 2016 was performed over 9 databases (Medline, PubMed, PsycARTICLES, CINAHL, Embase (excerpta medica), PsychInfo, Cochrane, Science citation index-expanded, Conference citation index) and a title-only search of Google scholar. 39 keyword combinations were employed: hypnosis, hypnotherapy, hypnotic, perception, beliefs, knowledge, view, opinion and understanding, in singular and plural where appropriate...
June 2017: Complementary Therapies in Medicine
https://www.readbyqxmd.com/read/28618603/analytical-solution-of-the-steady-membrane-voltage-fluctuation-caused-by-a-single-ion-channel
#18
Jia-Zeng Wang, Rui-Zhen Wang
An analytical steady-state solution of the stochastic model describing the integrated dynamics of the membrane voltage and the gating of a single channel is presented. The voltage density function experiences bifurcation in the parameter space, and the threshold is determined by the comparison between the rates of the voltage evolution and that of the channel gating. It is singular at the reversal potential if the voltage evolves faster than the channel gating. As an application, the entropy production rate associated with the gating currents is calculated; its variation tendency in parameter space is consistent to that of the number of transitions counted from the sample paths...
May 2017: Physical Review. E
https://www.readbyqxmd.com/read/28618491/minimum-spanning-tree-filtering-of-correlations-for-varying-time-scales-and-size-of-fluctuations
#19
Jarosław Kwapień, Paweł Oświęcimka, Marcin Forczek, Stanisław Drożdż
Based on a recently proposed q-dependent detrended cross-correlation coefficient, ρ_{q} [J. Kwapień, P. Oświęcimka, and S. Drożdż, Phys. Rev. E 92, 052815 (2015)PLEEE81539-375510.1103/PhysRevE.92.052815], we generalize the concept of the minimum spanning tree (MST) by introducing a family of q-dependent minimum spanning trees (qMSTs) that are selective to cross-correlations between different fluctuation amplitudes and different time scales of multivariate data. They inherit this ability directly from the coefficients ρ_{q}, which are processed here to construct a distance matrix being the input to the MST-constructing Kruskal's algorithm...
May 2017: Physical Review. E
https://www.readbyqxmd.com/read/28618471/energy-dissipation-anomaly-in-systems-of-localized-waves
#20
Basile Gallet
We study the statistics of the power P dissipated by waves propagating in a one-dimensional disordered medium with damping coefficient ν. An operator imposes the wave amplitude at one end, therefore injecting a power P that balances dissipation. The typical realization of P vanishes for ν→0: Disorder leads to localization and total reflection of the wave energy back to the emitter, with negligible losses. More surprisingly, the mean dissipated power 〈P〉 averaged over the disorder reaches a finite limit for ν→0...
May 2017: Physical Review. E
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