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propranolol tetralogy fallot

G Bronzetti, A Patrizi, F Giacomini, F Savoia, B Raone, M Brighenti, M Bonvicini, I Neri, G D Gargiulo
Infantile hemangiomas (IHs) are the most common benign tumors of infancy and usually they don't require specific therapy. In 10-20% of cases IHs are able to generate complication and medical/surgical intervention is needed. For many decades standard treatment consisted in oral or intralesional corticosteroids until Leaute-Labreze and colleagues published the first report on the efficacy of propranolol for cutaneous infantile hemangiomas in 2008. IHs can be sometimes part of complex syndrome. Here we report the case of a patient with tetralogy of Fallot operated at 5 month of age who stopped propranolol treatment for hypoxic spells and unusually developed facial and subglottic IHs configuring the diagnosis of PHACES syndrome (posterior fossa brain malformations, hemangioma, arterial anomalies, cardiac defects and/or aortic coarctation, ocular anomalies and sternal defects)...
2014: Current Medicinal Chemistry
Eric M Graham, Varsha M Bandisode, Scott M Bradley, Fred A Crawford, Janet M Simsic, Andrew M Atz
The aim of this study was to determine if preoperative propranolol therapy has a deleterious effect on postoperative variables in patients with tetralogy of Fallot. Data from 97 patients who underwent complete repair of tetralogy of Fallot were reviewed. The patients were divided into 2 groups: those receiving preoperative propranolol therapy (n = 32) and those not receiving therapy (n = 65). Preoperative and intraoperative variables did not differ between groups. There were no differences in postoperative inotrope scores on arrival to the intensive care unit and through the first 12 hours postoperatively...
March 1, 2008: American Journal of Cardiology
Alaa-Basiouni S Mahmoud, Amira El Tantawy, Amjad A Kouatli, Ghassan M Baslaim
Junctional ectopic tachycardia (JET) is a major cause of postoperative morbidity after complete repair of tetralogy of Fallot (TOF). Propranolol is a known medication used in patients with TOF to prevent and control hypercyanotic spells. Despite this, there is little information regarding the relation between preoperative use of propranolol and the incidence of postoperative JET. The aim of this study was to examine the effect of preoperative use of propranolol on the incidence of postoperative JET after full surgical repair of TOF...
April 2008: Interactive Cardiovascular and Thoracic Surgery
Cristina Sanches, Filomena R B G Galas, Anne G O de M Silva, Maria Jose C Carmona, José Otavio Auler, Silvia Regina Cavani Jorge Santos
OBJECTIVE: To evaluate the analytical micromethod using liquid chromatography for the quantification of propranolol in children submitted to surgery of tetralogy of Fallot (TLF). METHODS: Only 0.2 mL of plasma is required for the assay. Peaks eluted at 8.4 (Propranolol) and 17.5 min (verapamil, internal standard) from a C18 column, with a mobile phase 0.1 M acetate buffer, pH 5.0, and acetonitrile (60:40, v/v) at flow rate 0.7 mL/min, detected at 290 nm (excitation) and 358 nm (emission)...
June 2007: Clinics
J Walls, S Sanatani, R Hamilton
This report describes two patients diagnosed with congenital long QT syndrome after surgical repair of tetralogy of Fallot. Despite the fact that both patients had preoperative electrocardiograms demonstrating QT prolongation, neither was diagnosed until long after their surgeries, when they or their relatives presented with symptoms of long QT syndrome. A brief discussion highlights the reasons why long QT syndrome may be overlooked in patients with structural heart defects and the clinical importance of identifying these patients preoperatively...
January 2005: Pediatric Cardiology
A Heusch, A Tannous, O N Krogmann, M Bourgeois
Balloon valvoplasty was undertaken in 27 patients with tetralogy of Fallot for first-stage palliation. Indications were arterial saturation of oxygen < 80%, hypoxic spells and duct-dependant pulmonary perfusion. The dilation was performed following diagnostic heart catheterization. Saturations improved from 75% +/- 8.5 before valvoplasty to 85% +/- 8.4 after the procedure, and worsened little to 83% +/- 9.6 at follow-up after 3.4 months. The pulmonary valvar orifice was hypoplastic in most patients (Z = -3...
January 1999: Cardiology in the Young
C Holubarsch, G Hasenfuss, S Schmidt-Schweda, A Knorr, B Pieske, T Ruf, R Fasol, H Just
BACKGROUND: The renin-angiotensin system with its renal-humoral and local myocardial components plays an important role in the development and progression of chronic heart failure. Whereas angiotensin receptors have been found in atrial and ventricular myocardium of different species including humans, its influence on myocardial contractility is not yet defined in human failing myocardium and especially in human nonfailing myocardium. METHODS AND RESULTS: We measured force development of right atrial and right and left ventricular myocardial preparations of patients with a variety of cardiac diseases...
September 1993: Circulation
C I Berul, T L Sweeten, A M Dubin, M J Shah, V L Vetter
A prolonged rate-corrected QT interval (QTc) may be associated with an increased risk of developing ventricular arrhythmias and sudden death, particularly in patients with the hereditary long QT syndrome (LQTS), myocardial ischemia, or antiarrhythmic medication toxicity. It is known that there are some patients with LQTS who sometimes have a borderline or normal QTc (< or = 0.45 second). Although the QTc has been the standard measurement of ventricular repolarization, it includes both depolarization and repolarization and may not always be a sensitive indicator of the type of repolarization abnormalities seen in LQTS...
December 15, 1994: American Journal of Cardiology
J D Kugler, W W Pinsky, J P Cheatham, P J Hofschire, P K Mooring, W H Fleming
Ventricular arrhythmia originating from the outflow tract of the right ventricle is a presumed cause of late sudden death in patients after repair of tetralogy of Fallot. Exercise testing has been shown to enhance detection, and phenytoin has been shown to control ventricular arrhythmias in these patients. This study reports new findings in 3 patients who underwent electrophysiologic studies at postoperative cardiac catheterization; in each, sustained ventricular tachycardia was induced and found to originate from the inflow-septal area of the right ventricle...
April 1983: American Journal of Cardiology
M Schlemmer, M Wimmer
The indication and efficacy of mexiletine is described in five patients. In four children the first signs of arrhythmias were seen a short time after viral infection. Two girls had numerous ventricular extrasystoles, which showed very promptly a positive reaction to mexiletine. Two patients had ventricular tachycardias beside ventricular premature beats. Because of signs of cardial insufficiency a 13 year old boy was defibrillated before his cardiac rhythm could be established with mexiletine. Because of ventricular tachycardias the second patient was treated with a combination of mexiletine and propranolol...
1982: Pädiatrie und Pädologie
A Garson, P C Gillette, D G McNamara
No abstract text is available yet for this article.
May 1981: American Journal of Cardiology
A Garson, G A Gorry, D G McNamara, D A Cooley
No abstract text is available yet for this article.
January 1980: American Journal of Cardiology
G R Cumming, W Carr
No abstract text is available yet for this article.
July 1967: American Heart Journal
P M Shah, L Kidd
No abstract text is available yet for this article.
May 1967: American Journal of Cardiology
M Gautier
No abstract text is available yet for this article.
January 1969: Archives Françaises de Pédiatrie
B O Eriksson, C Thorén, P Zetterqvist
No abstract text is available yet for this article.
January 1969: British Heart Journal
N Kimura, H Toshima, S Nakakura, K Sasaki, A Mizunoe
No abstract text is available yet for this article.
October 1968: Japanese Circulation Journal
H Kato, M Hirose, M Yamaguchi, Y Yoshizawa, H Fukuda
No abstract text is available yet for this article.
December 1967: Japanese Circulation Journal
C Müler, W Dietzel, W Schmitz, H Wolter
No abstract text is available yet for this article.
April 1967: Der Anaesthesist
M Wimmer
No abstract text is available yet for this article.
May 1971: Monatsschrift Für Kinderheilkunde
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