Valentina Faihs, Claudia Kugler, Viktoria Schmalhofer, Katharina Anne Scherf, Barbara Lexhaller, Charlotte G Mortz, Carsten Bindslev-Jensen, Tilo Biedermann, Knut Brockow
Wheat-dependent exercise-induced anaphylaxis (WDEIA) is an IgE-mediated food allergy with allergic symptoms ranging from intermittent urticaria to severe anaphylaxis that occurs when wheat ingestion is combined with augmenting cofactors such as exercise, non-steroidal anti-inflammatory drugs, or alcohol. In most cases, patients are identified by sensitization to ω5-gliadins in the gluten fraction of wheat. ω5-gliadin-negative subtypes of WDEIA are often difficult to diagnose and may be caused by Tri a 14 (wheat lipid transfer protein), after percutaneous sensitization with hydrolyzed wheat proteins, or, in rare cases, by cross-reactivity to grass pollen...
July 18, 2023: Journal der Deutschen Dermatologischen Gesellschaft: JDDG