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https://www.readbyqxmd.com/read/28087826/comparison-of-brain-mri-findings-with-language-and-motor-function-in-the-dystroglycanopathies
#1
Brianna N Brun, Shelley R H Mockler, Katie M Laubscher, Carrie M Stephan, Anne M Wallace, Julia A Collison, M Bridget Zimmerman, William B Dobyns, Katherine D Mathews
OBJECTIVE: To describe the spectrum of brain MRI findings in a cohort of individuals with dystroglycanopathies (DGs) and relate MRI results to function. METHODS: All available brain MRIs done for clinical indications on individuals enrolled in a DG natural history study (NCT00313677) were reviewed. Reports were reviewed when MRI was not available. MRIs were categorized as follows: (1) cortical, brainstem, and cerebellar malformations; (2) cortical and cerebellar malformations; or (3) normal...
January 13, 2017: Neurology
https://www.readbyqxmd.com/read/28087823/prognosis-of-carotid-dissecting-aneurysms-results-from-cadiss-and-a-systematic-review
#2
Susanna C Larsson, Alice King, Jeremy Madigan, Christopher Levi, John W Norris, Hugh S Markus
OBJECTIVE: To determine the natural history of dissecting aneurysm (DA) and whether DA is associated with an increased recurrent stroke risk and whether type of antithrombotic drugs (antiplatelets vs anticoagulants) modifies the persistence or development of DA. METHODS: We included 264 patients with extracranial cervical artery dissection (CAD) from the Cervical Artery Dissection in Stroke Study (CADISS), a multicenter prospective study that compared antiplatelet with anticoagulation therapy...
January 13, 2017: Neurology
https://www.readbyqxmd.com/read/28087774/the-origin-of-mitochondrial-cristae-from-alphaproteobacteria
#3
Sergio A Muñoz-Gómez, Jeremy G Wideman, Andrew J Roger, Claudio H Slamovits
Mitochondria are the respiratory organelles of eukaryotes and their evolutionary history is deeply intertwined with that of eukaryotes. The compartmentalization of respiration in mitochondria occurs within cristae, whose evolutionary origin has remained unclear. Recent discoveries, however, have revived the old notion that mitochondrial cristae could have had a pre-endosymbiotic origin. Mitochondrial cristae are likely homologous to the intracytoplasmic membranes (ICMs) used by diverse alphaproteobacteria for harnessing energy...
January 12, 2017: Molecular Biology and Evolution
https://www.readbyqxmd.com/read/28087310/clinical-features-and-three-year-outcomes-of-takotsubo-stress-cardiomyopathy-observational-data-from-one-center
#4
Sigita Glaveckaitė, Pranas Šerpytis, Dovilė Pečiūraitė, Roma Puronaitė, Nomeda Valevičienė
OBJECTIVE: The natural history, management, and outcome of Takotsubo (stress) cardiomyopathy (TTC) is not clear. The aim of this study was to investigate clinical features, define prognostic predictors, and assess the clinical course and outcomes of patients with TTC. METHODS: We analyzed 64 patients (52 women) meeting the proposed Mayo Clinic diagnostic criteria for TTC. All patients were treated at Vilnius University Hospital Santariskiu Klinikos from 2001-01-01 to 2014-11-27...
November 16, 2016: Hellenic Journal of Cardiology: HJC, Hellēnikē Kardiologikē Epitheōrēsē
https://www.readbyqxmd.com/read/28087208/-child-langerhans-cell-histiocytosis
#5
Jean Donadieu, Sébastien Héritier
DEFINITION: Langerhans cell histiocytosis (LCH) is defined by the association of a clinical and radiological involvement and a biopsy of a pathological tissue. Extension: it can affect any organ or system of the body but most commonly the bone (80% of cases), the skin (33%) and the pituitary (25%). Other organs are concerned such as liver, spleen, hematopoietic system and the lungs (15% each), lymph nodes (5-10%) and central nervous system (CNS) excluding the pituitary (2-4%). Natural history: the natural history of the disease is very heterogeneous, ranging from auto-regressive lesions to a disease affecting multiple organs with fatal consequences, while some lesions may be responsible for permanent sequels...
January 10, 2017: La Presse Médicale
https://www.readbyqxmd.com/read/28086816/rationale-description-and-baseline-findings-of-a-community-based-prospective-cohort-study-of-kidney-function-amongst-the-young-rural-population-of-northwest-nicaragua
#6
Marvin González-Quiroz, Armando Camacho, Dorien Faber, Aurora Aragón, Catharina Wesseling, Jason Glaser, Jennifer Le Blond, Liam Smeeth, Dorothea Nitsch, Neil Pearce, Ben Caplin
BACKGROUND: An epidemic of Mesoamerican Nephropathy (MeN) is killing thousands of agricultural workers along the Pacific coast of Central America, but the natural history and aetiology of the disease remain poorly understood. We have recently commenced a community-based longitudinal study to investigate Chronic Kidney Disease (CKD) in Nicaragua. Although logistically challenging, study designs of this type have the potential to provide important insights that other study designs cannot...
January 13, 2017: BMC Nephrology
https://www.readbyqxmd.com/read/28081320/pityriasis-rosea-a-natural-history-of-pediatric-cases-in-thecentral-anatolia-region-of-turkey
#7
Emine Çölgeçen, Çiğdem Kader, Yılmaz Ulaş, Pınar Öztürk, Öznur Küçük, Mehmet Balcı
BACKGROUND/AIM: This study aimed to evaluate the demographic, clinical, and epidemiological features of pityriasis rosea (PR) in a cohort of 46 children in Yozgat, a city in the Central Anatolia Region of Turkey. MATERIALS AND METHODS: Forty-six children with PR were monitored at regular intervals (1, 2, 4, and 12 weeks) for 3 months from the time of diagnosis. A complete evaluation of the patient was performed at each visit. RESULTS: The average age of patients at time of diagnosis was 12 ± 3...
December 20, 2016: Turkish Journal of Medical Sciences
https://www.readbyqxmd.com/read/28081120/epidemiology-of-chikungunya-virus-outbreaks-in-guadeloupe-and-martinique-2014-an-observational-study-in-volunteer-blood-donors
#8
Pierre Gallian, Isabelle Leparc-Goffart, Pascale Richard, Françoise Maire, Olivier Flusin, Rachid Djoudi, Jacques Chiaroni, Remi Charrel, Pierre Tiberghien, Xavier de Lamballerie
BACKGROUND: During Dec-2013, a chikungunya virus (CHIKV) outbreak was first detected in the French-West Indies. Subsequently, the virus dispersed to other Caribbean islands, continental America and many islands in the Pacific Ocean. Previous estimates of the attack rate were based on declaration of clinically suspected cases. METHODS/PRINCIPAL FINDINGS: Individual testing for CHIKV RNA of all (n = 16,386) blood donations between Feb-24th 2014 and Jan-31st 2015 identified 0·36% and 0·42% of positives in Guadeloupe and Martinique, respectively...
January 2017: PLoS Neglected Tropical Diseases
https://www.readbyqxmd.com/read/28080094/lifetime-alcoholics-anonymous-attendance-as-a-predictor-of-spiritual-gains-in-the-relapse-replication-and-extension-project-rrep
#9
J Scott Tonigan, Elizabeth A McCallion, Tessa Frohe, Matthew R Pearson
This study investigated the association between extent of lifetime attendance in Alcoholics Anonymous (AA) and spiritual gains among treatment seeking adults for alcohol use disorder. Participants included 246 individuals from 2 of the 3 sites in the Relapse Replication and Extension Project (Lowman, Allen, Stout, & The Relapse Research Group, 1996). Baseline characteristics included 63% male, 39.9% single, and the average age was 34 years (SD = 8.2). The Alcoholics Anonymous Involvement questionnaire (Tonigan, Connors, & Miller, 1996) was used to assess lifetime AA attendance...
January 12, 2017: Psychology of Addictive Behaviors: Journal of the Society of Psychologists in Addictive Behaviors
https://www.readbyqxmd.com/read/28079559/strategies-to-alter-the-natural-history-of-childhood-asthma
#10
K A Lee-Sarwar, L B Bacharier, A A Litonjua
PURPOSE OF REVIEW: Asthma exhibits significant heterogeneity in occurrence and severity over the lifespan. Our goal is to discuss recent evidence regarding determinants of the natural history of asthma during childhood, and review the rationale behind and status of major efforts to alter its course. RECENT FINDINGS: Variations in microbial exposures are associated with risk of allergic disease, and the use of bacterial lysates may be a promising preventive strategy...
January 11, 2017: Current Opinion in Allergy and Clinical Immunology
https://www.readbyqxmd.com/read/28079282/troubling-issues-at-the-frontier-of-animal-tracking-for-conservation-and-management
#11
Steven J Cooke, Vivian M Nguyen, Steven T Kessel, Nigel E Hussey, Nathan Young, Adam T Ford
Developments in electronic tagging and tracking, including biotelemetry and biologging, have provided unprecedented insight into the ecology of wild animals (Cooke et al. 2004) and revealed hidden movement patterns, habitat associations, animal-environment interactions, and mortality rates for even the most cryptic of species (Hussey et al. 2015; Kays et al. 2015). Natural history, ecology (including movement ecology), conservation, and resource management have all benefitted from the application of this technology...
January 12, 2017: Conservation Biology: the Journal of the Society for Conservation Biology
https://www.readbyqxmd.com/read/28078624/millipede-defensive-compounds-are-a-double-edged-sword-natural-history-of-the-millipede-parasitic-genus-myriophora-brown-diptera-phoridae
#12
John M Hash, Jocelyn G Millar, John M Heraty, James F Harwood, Brian V Brown
Toxic defensive secretions produced by millipedes in the orders Julida, Spirobolida, Spirostreptida, and Polydesmida are highly repellent to most vertebrate and invertebrate natural enemies, but a few insects have evolved mechanisms to overcome these defenses. We demonstrate that highly specialized parasitic phorid flies in the species-rich genus Myriophora use volatile millipede defensive compounds as kairomones for host location. Of the two predominant quinone components in the defensive blend of juliform millipedes, 2-methoxy-3-methyl-1,4-benzoquinone alone was sufficient to attract adult flies of both sexes; however, a combination of 2-methoxy-3-methyl-1,4-benzoquinone and 2-methyl-1,4-benzoquinone increased attractiveness nearly threefold...
January 11, 2017: Journal of Chemical Ecology
https://www.readbyqxmd.com/read/28078499/carbonaceous-chondrite-meteorites-the-chronicle-of-a-potential-evolutionary-path-between-stars-and-life
#13
Sandra Pizzarello, Everett Shock
The biogenic elements, H, C, N, O, P and S, have a long cosmic history, whose evolution can still be observed in diverse locales of the known universe, from interstellar clouds of gas and dust, to pre-stellar cores, nebulas, protoplanetary discs, planets and planetesimals. The best analytical window into this cosmochemical evolution as it neared Earth has been provided so far by the small bodies of the Solar System, some of which were not significantly altered by the high gravitational pressures and temperatures that accompanied the formation of larger planets and may carry a pristine record of early nebular chemistry...
January 11, 2017: Origins of Life and Evolution of the Biosphere
https://www.readbyqxmd.com/read/28078222/testosterone-replacement-therapy-and-the-heart-friend-foe-or-bystander
#14
REVIEW
David S Lopez, Steven Canfield, Run Wang
The role of testosterone therapy (TTh) in cardiovascular disease (CVD) outcomes is still controversial, and it seems will remain inconclusive for the moment. An extensive body of literature has investigated the association of endogenous testosterone and use of TTh with CVD events including several meta-analyses. In some instances, a number of studies reported beneficial effects of TTh on CVD events and in other instances the body of literature reported detrimental effects or no effects at all. Yet, no review article has scrutinized this body of literature using the magnitude of associations and statistical significance reported from this relationship...
December 2016: Translational Andrology and Urology
https://www.readbyqxmd.com/read/28078104/discovery-of-flavivirus-derived-endogenous-viral-elements-in-anopheles-mosquito-genomes-supports-the-existence-of-anopheles-associated-insect-specific-flaviviruses
#15
Sebastian Lequime, Louis Lambrechts
The Flavivirus genus encompasses several arboviruses of public health significance such as dengue, yellow fever, and Zika viruses. It also includes insect-specific flaviviruses (ISFs) that are only capable of infecting insect hosts. The vast majority of mosquito-infecting flaviviruses have been associated with mosquito species of the Aedes and Culex genera in the Culicinae subfamily, which also includes most arbovirus vectors. Mosquitoes of the Anophelinae subfamily are not considered significant arbovirus vectors; however, flaviviruses have occasionally been detected in field-caught Anopheles specimens...
January 2017: Virus Evolution
https://www.readbyqxmd.com/read/28077842/psychoanalysis-and-the-emigration-of-central-and-eastern-european-intellectuals
#16
Ferenc Erős
One of the most important phenomena in the intellectual history of the 20th century was the exodus of the European mind, the emigration of persons, ideas, techniques, and institutions in the vast areas of social, human, and natural sciences, as well as in literature and the visual arts. Among these exiled intellectuals, psychoanalysts formed a special group. This paper examines the major lines of the emigration of psychoanalysts from the countries of issue to the countries of reception. It focuses, in particular on Hungarian analysts and analytic candidates who left their country of birth in two waves, first after the failure of revolutions in 1918/19 for Berlin, and then after 1938, to escape the Nazis...
December 2016: American Journal of Psychoanalysis
https://www.readbyqxmd.com/read/28077698/detection-of-antigenic-variants-of-swine-subtype-h3-influenza-a-viruses-from-clinical-samples
#17
Brigitte E Martin, Andrew S Bowman, Lei Li, Jacqueline M Nolting, David R Smith, Larry A Hanson, Xiu-Feng Wan
A large population of genetically and antigenically diverse influenza A viruses (IAVs) are circulating among the swine population, playing an important role in influenza ecology. Swine IAVs not only cause outbreaks among swine, but they can also be transmitted to humans, causing sporadic infections and even pandemic outbreaks. Antigenic characterization of swine IAVs are key to understanding the natural history of these viruses in swine and to selecting strains for effective vaccines. However, influenza outbreaks generally spread rapidly among swine, and the conventional methods for antigenic characterization require virus propagation, a time-consuming process that can significantly reduce the effectiveness of vaccination programs...
January 11, 2017: Journal of Clinical Microbiology
https://www.readbyqxmd.com/read/28077688/pattern-process-inference-and-prediction-in-extinction-biology
#18
Barry W Brook, John Alroy
Extinction is a key feature of the evolutionary history of life, and assessments of extinction risk are essential for the effective protection of biodiversity. The goal in assembling this special issue of Biology Letters was to highlight problems and questions at the research frontier of extinction biology, with an emphasis on recent developments in the methodology of inferring the patterns and processes of extinction from a background of often noisy and sparse data. In selecting topics, we sought to illustrate how extinction is not simply a self-evident phenomenon, but the subject of a dynamic and quantitatively rigorous field of natural science, with practical applications to conservation...
January 2017: Biology Letters
https://www.readbyqxmd.com/read/28077633/surveillance-of-bat-coronaviruses-in-kenya-identifies-relatives-of-human-coronaviruses-nl63-and-229e-and-their-recombination-history
#19
Ying Tao, Mang Shi, Christina Chommanard, Krista Queen, Jing Zhang, Wanda Markotter, Ivan V Kuzmin, Edward C Holmes, Suxiang Tong
: Bats harbor a large diversity of coronaviruses (CoVs), several of which are related to zoonotic pathogens that cause severe disease in humans. Our screening of bat samples collected in Kenya during 2007-2010 not only detected RNA from several novel CoVs but, more significantly, identified sequences that were closely related to human CoVs NL63 and 229E, suggesting that these two human viruses originate from bats. We also demonstrated that human CoV NL63 is a recombinant between NL63-like viruses circulating in Triaenops bats and 229E-like viruses circulating in Hipposideros bats, with the break-point located near 5' and 3' end of the spike (S) protein gene...
January 11, 2017: Journal of Virology
https://www.readbyqxmd.com/read/28077326/longevity-in-calumma-parsonii-the-world-s-largest-chameleon
#20
Giulia Tessa, Frank Glaw, Franco Andreone
Large body size of ectothermic species can be correlated with high life expectancy. We assessed the longevity of the world's largest chameleon, the Parson's chameleon Calumma parsonii from Madagascar by using skeletochronology of phalanges taken from preserved specimens held in European natural history museums. Due to the high bone resorption we can provide only the minimum age of each specimen. The highest minimum age detected was nine years for a male and eight years for a female, confirming that this species is exceptionally long living among chameleons...
January 8, 2017: Experimental Gerontology
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