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alcoholism and topiramate

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https://www.readbyqxmd.com/read/28776162/treatment-for-negative-symptoms-in-schizophrenia-a-comprehensive-review
#1
REVIEW
Selene R T Veerman, Peter F J Schulte, Lieuwe de Haan
Negative symptoms (such as amotivation and diminished expression) associated with schizophrenia are a major health concern. Adequate treatment would mean important progress with respect to quality of life and participation in society. Distinguishing primary from secondary negative symptoms may inform treatment options. Primary negative symptoms are part of schizophrenia. Well-known sources of secondary negative symptoms are psychotic symptoms, disorganisation, anxiety, depression, chronic abuse of illicit drugs and alcohol, an overly high dosage of antipsychotic medication, social deprivation, lack of stimulation and hospitalisation...
August 3, 2017: Drugs
https://www.readbyqxmd.com/read/28669022/pharmacological-treatment-of-bipolar-disorder-with-comorbid-alcohol-use-disorder
#2
Andrew Naglich, Bryon Adinoff, E Sherwood Brown
Bipolar disorder (BD) spectrum and alcohol use disorders (AUDs) commonly occur together. Comorbidity between the two conditions predisposes patients to elevated risks of adverse outcomes, including hospitalization and suicide, compared with either condition alone. Despite the consistent relationship observed between BD and AUD, the underlying cause remains incompletely characterized. Few trials conducted have been able to identify promising interventions for patients with these disease states. The antipsychotic quetiapine has been evaluated most commonly as a therapeutic agent for patients with BD and AUD followed by naltrexone and acamprosate...
August 2017: CNS Drugs
https://www.readbyqxmd.com/read/28658981/pharmacotherapy-of-alcoholism-an-update-on-approved-and-off-label-medications
#3
Michael Soyka, Christian A Müller
Only a few medications are available for the treatment of alcohol use disorders (AUDs). Areas covered: This paper discusses approved AUD medications, including the opioid antagonists naltrexone and nalmefene (the latter is licensed for reduction of alcohol consumption only), the putative glutamate receptor antagonist acamprosate and the aldehyde dehydrogenase inhibitor disulfiram. It also covers off-label medications of interest, including topiramate, gabapentin, ondansetron, varenicline, baclofen, sodium oxybate and antidepressants...
August 2017: Expert Opinion on Pharmacotherapy
https://www.readbyqxmd.com/read/28319159/drug-therapy-for-alcohol-dependence-in-primary-care-in-the-uk-a-clinical-practice-research-datalink-study
#4
Andrew Thompson, Darren M Ashcroft, Lynn Owens, Tjeerd P van Staa, Munir Pirmohamed
AIM: To evaluate drug therapy for alcohol dependence in the 12 months after first diagnosis in UK primary care. DESIGN: Open cohort study. SETTING: General practices contributing data to the UK Clinical Practice Research Database. PARTICIPANTS: 39,980 people with an incident diagnosis of alcohol dependence aged 16 years or older between 1 January 1990 and 31 December 2013. MAIN OUTCOME MEASURE: Use of pharmacotherapy (acamprosate, disulfiram, naltrexone, baclofen and topiramate) to promote abstinence from alcohol or reduce drinking to safe levels in the first 12 months after a recorded diagnosis of alcohol dependence...
2017: PloS One
https://www.readbyqxmd.com/read/28317503/type-a-type-b-alcoholism-predicts-differential-response-to-topiramate-in-a-smoking-cessation-trial-in-dually-diagnosed-men
#5
Melodie Isgro, Neal Doran, Jaimee L Heffner, Esther Wong, Elizabeth Dinh, Jessie Tibbs, Katie Russell, Tracy Bittner, Chris Wehrle, Matthew J Worley, Robert M Anthenelli
OBJECTIVE: Babor's A/B typology characterizes alcohol-dependence subtypes, which differ across multiple defining variables; however, differences in cigarette smoking and cessation between these subtypes have not been previously investigated. Topiramate reduces heavy drinking and has separately been found to help non-alcohol-dependent individuals quit smoking. This study tested the hypothesis that topiramate's effects on smoking would be moderated by alcohol-dependence subtype, and explored craving as a mediator of this response...
March 2017: Journal of Studies on Alcohol and Drugs
https://www.readbyqxmd.com/read/28301219/management-of-comorbid-bipolar-disorder-and-substance-use-disorders
#6
Ihsan M Salloum, Edson Sherwood Brown
BACKGROUND: The comorbidity of substance use disorders (SUDs) in bipolar disorder is among the highest in psychiatric disorders. Evidence-based controlled psychosocial or pharmacological interventions trials, which may guide treatment decisions, have not been systematically reviewed. OBJECTIVE: To present a narrative review of the public health and clinical significance of this condition, including diagnostic and treatment implications, and to evaluate controlled trials conducted to date...
July 2017: American Journal of Drug and Alcohol Abuse
https://www.readbyqxmd.com/read/28220511/review-article-pharmacotherapy-for-alcohol-dependence-the-why-the-what-and-the-wherefore
#7
REVIEW
E T Goh, M Y Morgan
BACKGROUND: The development of alcohol dependence is associated with significant morbidity and mortality. For the majority of affected people the most appropriate goal, in terms of drinking behaviour, is abstinence from alcohol. Psychosocial intervention is the mainstay of the treatment but adjuvant pharmacotherapy is also available and its use recommended. AIM: To provide an updated analysis of current and potential pharmacotherapeutic options for the management of alcohol dependence...
April 2017: Alimentary Pharmacology & Therapeutics
https://www.readbyqxmd.com/read/28134463/review-pharmacogenetics-of-alcoholism-treatment-implications-of-ethnic-diversity
#8
REVIEW
Anita Cservenka, Megan M Yardley, Lara A Ray
BACKGROUND AND OBJECTIVES: Pharmacogenetic studies of alcohol use disorder (AUD) have suggested that the efficacy of treatments for AUD is, in part, influenced by the genetic background of an individual. Since the frequency of alleles associated with pharmacotherapy for AUD varies by ancestral background, the effectiveness of medications used to treat AUD may vary among different populations. The purpose of this review is to summarize the existing pharmacogenetic studies of treatments for AUD in individuals of European, East Asian, African, and American Indian/Alaska Native ancestry...
August 2017: American Journal on Addictions
https://www.readbyqxmd.com/read/28029173/a-randomized-trial-evaluating-whether-topiramate-aids-smoking-cessation-and-prevents-alcohol-relapse-in-recovering-alcohol-dependent-men
#9
Robert M Anthenelli, Jaimee L Heffner, Esther Wong, Jessie Tibbs, Katie Russell, Melodie Isgro, Elizabeth Dinh, Chris Wehrle, Matthew J Worley, Neal Doran
BACKGROUND: Alcohol and nicotine dependence frequently co-occur, and quitting smoking might enhance long-term alcohol abstinence. Topiramate appears to help non-alcohol-dependent individuals quit smoking, and our pilot work suggested efficacy only in men. It also prevents relapse to alcohol in recently detoxified alcoholics. We evaluated topiramate in abstinent alcohol-dependent men to assess whether this medication (i) promotes smoking cessation and (ii) prevents alcohol and other drug relapse in the context of smoking cessation treatment...
January 2017: Alcoholism, Clinical and Experimental Research
https://www.readbyqxmd.com/read/27903560/commonly-prescribed-drugs-associate-with-cognitive-function-a-cross-sectional-study-in-uk-biobank
#10
Alejo J Nevado-Holgado, Chi-Hun Kim, Laura Winchester, John Gallacher, Simon Lovestone
OBJECTIVE: To investigate medications associated with cognitive function. DESIGN: Population-based cross-sectional cohort study. SETTING: UK Biobank. PARTICIPANTS: UK Biobank participants aged 37-73 years who completed cognitive tests at the baseline visit in 2006-2010. MAIN OUTCOME MEASURES: Cognitive test outcomes on verbal-numerical reasoning test (n=165 493), memory test (n=482 766) and reaction time test (n=496 813)...
November 30, 2016: BMJ Open
https://www.readbyqxmd.com/read/27778480/mechanisms-of-topiramate-effects-refining-medications-development-for-alcoholism
#11
(no author information available yet)
No abstract text is available yet for this article.
November 2016: Addiction Biology
https://www.readbyqxmd.com/read/27633982/multifaceted-academic-detailing-program-to-increase-pharmacotherapy-for-alcohol-use-disorder-interrupted-time-series-evaluation-of-effectiveness
#12
Alex H S Harris, Thomas Bowe, Hildi Hagedorn, Andrea Nevedal, Andrea K Finlay, Risha Gidwani, Craig Rosen, Chad Kay, Melissa Christopher
BACKGROUND: Active consideration of effective medications to treat alcohol use disorder (AUD) is a consensus standard of care, yet knowledge and use of these medications are very low across diverse settings. This study evaluated the overall effectiveness a multifaceted academic detailing program to address this persistent quality problem in the US Veterans Health Administration (VHA), as well as the context and process factors that explained variation in effectiveness across sites. METHODS: An interrupted time series design, analyzed with mixed-effects segmented logistic regression, was used to evaluate changes in level and rate of change in the monthly percent of patients with a clinically documented AUD who received naltrexone, acamprosate, disulfiram, or topiramate...
September 15, 2016: Addiction Science & Clinical Practice
https://www.readbyqxmd.com/read/27449273/a-delta-opioid-receptor-genetic-variant-is-associated-with-abstinence-prior-to-and-during-cocaine-dependence-treatment
#13
R C Crist, G A Doyle, K M Kampman, W H Berrettini
INTRODUCTION: An intronic polymorphism in the delta-opioid receptor gene (OPRD1) was previously associated with cocaine dependence in African-Americans. However, it is not known if the polymorphism (rs678849) is associated with dependence-related phenotypes within the cocaine dependent population. METHODS: Cocaine and alcohol dependent subjects were randomized to either topiramate or placebo. Abstinence from cocaine use was confirmed by urine drug screens for benzoylecgonine three times per week...
September 1, 2016: Drug and Alcohol Dependence
https://www.readbyqxmd.com/read/27293943/topiramate-induced-persistent-eyelid-myokymia
#14
Mohammadrasoul Khalkhali
Background. Topiramate (TPM) is a psychotropic drug, which is used mainly as an antiepileptic drug and now over the years is used for a wider range of indications, including migraine prophylaxis and binge eating disorders. Although ocular side effects of Topiramate have been frequently reported, neuroophthalmologic manifestations such as myokymia are rarely reported. Case Presentation. This case report presents a case of a 47-year-old woman who had begun TPM for binge eating problem. She developed unilateral long standing lower eyelid twitching, which progressed to upper eyelid and eyebrow at the same side...
2016: Case Reports in Psychiatry
https://www.readbyqxmd.com/read/27015372/detection-of-drugs-in-275-alcohol-positive-blood-samples-of-korean-drivers
#15
Eunmi Kim, Sanggil Choe, Juseon Lee, Moonhee Jang, Hyeyoung Choi, Heesun Chung
Since driving under the influence of drugs (DUID) is as dangerous as drink-driving, many countries regulate DUID by law. However, laws against the use of drugs while driving are not yet established in Korea. In order to investigate the type and frequency of drugs used by drivers in Korea, we analyzed controlled and non-controlled drugs in alcohol-positive blood samples. Total 275 blood samples were taken from Korean drivers, which were positive in roadside alcohol testing. The following analyses were performed: blood alcohol concentrations by GC; screening for controlled drugs by immunoassay and confirmation for positive samples by GC-MS...
August 2016: Forensic Science International
https://www.readbyqxmd.com/read/27008795/alcohol-dependence-neurobiology-and-treatment
#16
REVIEW
Agnieszka Michalak, Grazyna Biała
The consequences of alcohol dependence concern serious health care, social and economic problems. The scope of many studies is to better understand mechanisms underlying alcohol addiction in order to work out new, more effective treatment strategies. Alcohol affects many neurotransmission systems within the brain. In general, acute alcohol enhances inhibitory transmission, up-regulating the GABAergic system and impairing glutamatergic function, therefore interfering the balance between excitatory and inhibitory synaptic inputs...
January 2016: Acta Poloniae Pharmaceutica
https://www.readbyqxmd.com/read/26977830/medications-for-alcohol-use-disorder
#17
REVIEW
Bradford T Winslow, Mary Onysko, Melanie Hebert
The U.S. Preventive Services Task Force recommends that clinicians screen adults for alcohol misuse and provide persons engaged in risky or hazardous drinking behaviors with brief behavioral counseling to reduce alcohol misuse. However, only a minority of American adults with high-risk alcohol use receive treatment. Three medications are approved by the U.S. Food and Drug Administration to treat alcohol use disorder: acamprosate, disulfiram, and naltrexone. Acamprosate and naltrexone reduce alcohol consumption and increase abstinence rates, although the effects appear to be modest...
March 15, 2016: American Family Physician
https://www.readbyqxmd.com/read/26928397/potential-medications-for-the-treatment-of-alcohol-use-disorder-an-evaluation-of-clinical-efficacy-and-safety
#18
Raye Z Litten, Bonnie B Wilford, Daniel E Falk, Megan L Ryan, Joanne B Fertig
Alcohol use disorder (AUD), as currently defined in the Diagnostic and Statistical Manual, 5th Edition (DSM-5), is a heterogeneous disorder stemming from a complex interaction of neurobiological, genetic, and environmental factors. As a result of this heterogeneity, there is no one treatment for AUD that will work for everyone. During the past 2 decades, efforts have been made to develop a menu of medications to give patients and clinicians more choices when seeking a therapy that is both effective and which has limited side effects...
April 2016: Substance Abuse
https://www.readbyqxmd.com/read/26894822/a-randomized-placebo-controlled-proof-of-concept-trial-of-adjunctive-topiramate-for-alcohol-use-disorders-in-bipolar-disorder
#19
RANDOMIZED CONTROLLED TRIAL
Louisa G Sylvia, Alexandra K Gold, Jonathan P Stange, Andrew D Peckham, Thilo Deckersbach, Joseph R Calabrese, Roger D Weiss, Roy H Perlis, Andrew A Nierenberg, Michael J Ostacher
BACKGROUND AND OBJECTIVES: Topiramate is effective for alcohol use disorders (AUDs) among non-psychiatric patients. We examined topiramate for treating comorbid AUDs in bipolar disorder (BD). METHODS: Twelve participants were randomized to topiramate or placebo for 12 weeks. RESULTS: The topiramate group, with two out of five participants (40%) completing treatment, experienced less improvement in drinking patterns than the placebo group, with five out of seven participants (71%) completing treatment...
March 2016: American Journal on Addictions
https://www.readbyqxmd.com/read/26819510/alcoholic-liver-disease-and-hepatitis-c-virus-infection
#20
REVIEW
Ignacio Novo-Veleiro, Lucía Alvela-Suárez, Antonio-Javier Chamorro, Rogelio González-Sarmiento, Francisco-Javier Laso, Miguel Marcos
Alcohol consumption and hepatitis C virus (HCV) infection have a synergic hepatotoxic effect, and the coexistence of these factors increases the risk of advanced liver disease. The main mechanisms of this effect are increased viral replication and altered immune response, although genetic predisposition may also play an important role. Traditionally, HCV prevalence has been considered to be higher (up to 50%) in alcoholic patients than in the general population. However, the presence of advanced alcoholic liver disease (ALD) or intravenous drug use (IDU) may have confounded the results of previous studies, and the real prevalence of HCV infection in alcoholic patients without ALD or prior IDU has been shown to be lower...
January 28, 2016: World Journal of Gastroenterology: WJG
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