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Haemorrhagic fever

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https://www.readbyqxmd.com/read/29764527/an-outbreak-of-haemorrhagic-fever-with-renal-syndrome-linked-with-mountain-recreational-activities-in-zagreb-croatia-2017
#1
Z Lovrić, B Kolarić, M L Kosanović Ličina, M Tomljenović, O Đaković Rode, K Danis, B Kaić, V Tešić
In 2017 Zagreb faced the largest outbreak of haemorrhagic fever with renal syndrome (HFRS) to date. We investigated to describe the extent of the outbreak and identify risk factors for infection. We compared laboratory-confirmed cases of Hantavirus infection in Zagreb residents with the onset of illness after 1 January 2017, with individually matched controls from the same household or neighbourhood. We calculated adjusted matched odds ratios (amOR) using conditional logistic regression. During 2017, 104 cases were reported: 11-81 years old (median 37) and 71% (73) male...
May 16, 2018: Epidemiology and Infection
https://www.readbyqxmd.com/read/29753653/cardiopulmonary-bypass-in-non-cardiac-surgery
#2
Timothy Luke Surman, Michael George Worthington, Jose Martinelli Nadal
BACKGROUND: Cardiopulmonary bypass (CPB) and extracorporeal membrane oxygenation (ECMO) are used to facilitate circulatory support in standard cardiac surgery and emergency intervention, but CPB and ECMO are not used routinely in non-cardiac surgery involving the thorax and major vessels. The primary aim of this study was to identify the type of non-cardiac procedures and bypass used in our institution and review the patient outcomes including perioperative and bypass complications. METHODS: A retrospective study was performed within the Royal Adelaide Hospital Cardiothoracic Surgery Unit (CTSU) that examined all operations between 2006 and 2014...
April 19, 2018: Heart, Lung & Circulation
https://www.readbyqxmd.com/read/29743940/delayed-anxiety-and-depressive-morbidity-among-dengue-patients-in-a-multi-ethnic-urban-setting-first-report-from-sri-lanka
#3
Nayana Gunathilaka, Miyuru Chandradasa, Layani Champika, Shirom Siriwardana, Lakmini Wijesooriya
Background: Although the physical consequences of dengue are well documented, delayed psychological co-morbidities are not well studied to date. Therefore, the objective of the present study was to determine the prevalence of depressive, anxiety and stress symptoms among past dengue patients. Methods: A community-based, case-control study in a multi-ethnic urban setting was conducted in Sri Lanka involving adults who were diagnosed to have dengue fever by a positive dengue IgM antibody response between 6 and 24 months ago...
2018: International Journal of Mental Health Systems
https://www.readbyqxmd.com/read/29733017/zenker-diverticulum-treatment-endoscopic-or-surgical
#4
Diana Ciuc, Rodica Birlă, Eugenia Panaitescu, Marcel Tanţău, Silviu Constantinoiu
Introduction: The Zenker Diverticulum is a rare pathology, the selection of patients for invasive treatments is questionable, as well as the applied therapeutic method. The aim of the study is to evaluate the main methods of classical and endoscopic surgical treatment in this pathology and to correlate pathophysiological aspects with clinical consequences. MATERIAL AND METHOD: We included 36 patients with Zenker hypopharyngeal diverticulum treated in 2010/2017 in two university clinics: 7 patients by classical surgical approach at the General and Esophageal Surgery Clinic of St...
March 2018: Chirurgia
https://www.readbyqxmd.com/read/29726966/pattern-of-dengue-virus-infections-in-adult-patients-from-sri-lanka
#5
Umesh Jayarajah, Pradeep K de Silva, Priyankara Jayawardana, Upul Dissanayake, Aruna Kulatunga, Harshini Fernando, Lakshika Perera, Vibhavee Kannangara, Champika Udayangani, Ranga Peiris, Shuaib Faizer, Pamodh Yasawardene, Ishan de Zoysa, Suranjith L Seneviratne
Background: Sri Lanka experienced its largest dengue epidemic in 2017. This study describes the disease pattern of adult dengue patients from two hospitals in Sri Lanka. Methods: Demographic, clinical and investigation findings of adult dengue patients admitted to the two hospitals from June to August 2017 were collected and analysed. Results: A total of 1167 patients (777 males [66.2%], mean age 32.9 y) were studied. There were 775 (66.4%) patients with dengue fever (DF), 334 (28...
May 2, 2018: Transactions of the Royal Society of Tropical Medicine and Hygiene
https://www.readbyqxmd.com/read/29713918/high-seroprevalence-for-crimean-congo-haemorrhagic-fever-virus-in-ruminants-in-the-absence-of-reported-human-cases-in-many-regions-of-bulgaria
#6
Iva Christova, Elitsa Panayotova, Martin H Groschup, Iva Trifonova, Simona Tchakarova, Miriam Andrada Sas
Crimean-Congo haemorrhagic fever (CCHF) is a severe tick-borne zoonotic disease in humans caused by CCHF virus. It has been observed in Bulgaria since 1952 and over the years more than 1600 cases have been reported in the country. Close contact with viraemic livestock was shown as one of the main causes of the infection. Detection of CCHF virus specific antibodies in livestock can be used as an indicator for virus circulation and risk assessment. CCHF seroprevalence was investigated in 843 cattle, 88 goats and 130 sheep, originating from all 28 districts of Bulgaria...
April 30, 2018: Experimental & Applied Acarology
https://www.readbyqxmd.com/read/29709967/the-development-of-a-novel-diagnostic-assay-that-uses-a-pseudotyped-vesicular-stomatitis-virus-for-the-detection-of-neutralising-activity-to-crimean-congo-haemorrhagic-fever-virus
#7
Yuto Suda, John Chamberlain, Stuart Dowall, Masayuki Saijo, Taisuke Horimoto, Roger Hewson, Masayuki Shimojima
Crimean-Congo haemorrhagic fever virus is a risk group 4 pathogen, which mandates the use of maximum containment facilities, often called biosafety level 4 (BSL-4) or containment level 4 (CL-4) laboratories when working with infectious materials. Diagnostic and research work involving live viruses in such laboratories is time-consuming and awkward resulting in delays. We herein show that the serum neutralising activity against the virus can be measured in low-containment laboratories using a pseudotyped virus...
April 27, 2018: Japanese Journal of Infectious Diseases
https://www.readbyqxmd.com/read/29706314/dengue-haemorrhagic-fever-an-emerging-disease-in-nigeria-west-africa
#8
REVIEW
Ademola Hezekiah Fagbami, Anyebe Bernard Onoja
INTRODUCTION: In Nigeria, dengue fever caused by dengue virus, types 1 and 2 has been diagnosed for many years. Although, seroepidemiological surveys have shown that dengue virus activity is, widespread in the country, there is scanty information on dengue, hemorrhagic fever with little attention paid to dengue fever largely, because it presents as classical dengue fever characterized by fever, myalgia, headache, arthralgia, retro-orbital pain, gastro intestinal, symptoms and skin rash...
April 26, 2018: Journal of Infection and Public Health
https://www.readbyqxmd.com/read/29693726/uterotonic-agents-for-preventing-postpartum-haemorrhage-a-network-meta-analysis
#9
REVIEW
Ioannis D Gallos, Helen M Williams, Malcolm J Price, Abi Merriel, Harold Gee, David Lissauer, Vidhya Moorthy, Aurelio Tobias, Jonathan J Deeks, Mariana Widmer, Özge Tunçalp, Ahmet Metin Gülmezoglu, G Justus Hofmeyr, Arri Coomarasamy
BACKGROUND: Postpartum haemorrhage (PPH) is the leading cause of maternal mortality worldwide. Prophylactic uterotonic drugs can prevent PPH, and are routinely recommended. There are several uterotonic drugs for preventing PPH but it is still debatable which drug is best. OBJECTIVES: To identify the most effective uterotonic drug(s) to prevent PPH, and generate a ranking according to their effectiveness and side-effect profile. SEARCH METHODS: We searched Cochrane Pregnancy and Childbirth's Trials Register (1 June 2015), ClinicalTrials...
April 25, 2018: Cochrane Database of Systematic Reviews
https://www.readbyqxmd.com/read/29676526/crimean-congo-haemorrhagic-fever-virus-past-present-and-future-insights-for-animal-modelling-and-medical-countermeasures
#10
REVIEW
E J Mendoza, B Warner, D Safronetz, C Ranadheera
Crimean-Congo haemorrhagic fever (CCHF) is a widespread tick-borne viral zoonosis with a case-fatality rate ranging from 9% to 50% in humans. Although a licensed vaccine to prevent infection by the CCHF virus (CCHFV) exists, its ability to induce neutralizing antibodies is limited and its efficacy against CCHFV remains undetermined. In addition, controlling CCHF infections by eradication of the tick reservoir has been ineffective, both economically and logistically, and the treatment options for CCHF remain limited...
April 20, 2018: Zoonoses and Public Health
https://www.readbyqxmd.com/read/29674053/chimeric-dna-lna-based-biosensor-for-the-rapid-detection-of-african-swine-fever-virus
#11
Massimo Biagetti, Massimiliano Cuccioloni, Laura Bonfili, Valentina Cecarini, Carla Sebastiani, Ludovica Curcio, Monica Giammarioli, Gian Mario De Mia, Anna Maria Eleuteri, Mauro Angeletti
African swine fever (ASF) virus is a DNA virus responsible for a severe haemorrhagic fever in pigs, which (still in the absence of vaccination strategies) results in high mortality rates. Herein, we present a biosensor-based method for the detection of ASF viral DNA in the blood of pigs. The biosensor exploits a single-strand DNA probe with locked nucleic acid nucleotides (LNA) substitutions as the complementary recognition element for the conserved region of vp72 gene of ASF virus. The biosensor was calibrated using qPCR-quantified ASF viral DNA extracted from the blood of pigs experimentally infected with the virulent Italian isolate 49/08, genotype I...
July 1, 2018: Talanta
https://www.readbyqxmd.com/read/29607366/blood-group-ab-is-associated-with-severe-forms-of-dengue-virus-infection
#12
Kalamathy Murugananthan, Sivaganesh Subramaniyam, Thirunavukarasu Kumanan, Leigh Owens, Natkunam Ketheesan, Faseeha Noordeen
Several viral and host factors are believed to contribute to the development of severe forms of dengue such as dengue haemorrhagic fever (DHF) and dengue shock syndrome (DSS) following a dengue virus (DENV) infection. The pathogenesis of DHF/DSS is not fully understood, however, host factors like ABO blood groups have been shown to contribute to the severity of DENV infection. The present study investigated the association of blood groups with severity of DENV infection in the northern region of Sri Lanka. The blood-groups of 405 patients positive for DENV NS1 antigen and anti-DENV IgM/IgG were determined using the standard haemagglutination assay recommended by the national blood bank/s...
March 2018: Virusdisease
https://www.readbyqxmd.com/read/29594846/prevalence-and-spatial-distribution-of-ixodid-tick-populations-in-the-forest-fringes-of-western-ghats-reported-with-human-cases-of-kyasanur-forest-disease-and-monkey-deaths-in-south-india
#13
C Sadanandane, M D Gokhale, A Elango, P Yadav, D T Mourya, P Jambulingam
Kyasanur forest disease (KFD) is a major tick-borne viral haemorrhagic fever caused by KFD virus (KFDV) (Flaviviridae). The disease was reported to be confined to five districts of Karnataka state India until 2011. During 2012-2016, emergence of KFD has been reported in newer areas of Karnataka and adjoining states. Therefore, survey of tick vectors was carried out in these new areas of Karnataka and adjoining states reported with monkey deaths and human cases of KFD. In all selected sites, ticks from the forest floor were collected by lint clothes using flagging method...
March 28, 2018: Experimental & Applied Acarology
https://www.readbyqxmd.com/read/29582758/impact-of-enhanced-viral-haemorrhagic-fever-surveillance-on-outbreak-detection-and-response-in-uganda
#14
Trevor R Shoemaker, Stephen Balinandi, Alex Tumusiime, Luke Nyakarahuka, Julius Lutwama, Edward Mbidde, Aaron Kofman, John D Klena, Ute Ströher, Pierre E Rollin, Stuart T Nichol
No abstract text is available yet for this article.
April 2018: Lancet Infectious Diseases
https://www.readbyqxmd.com/read/29580643/japanese-encephalitis-virus-yellow-fever-virus-chimera-is-safe-and-confers-full-protection-against-yellow-fever-virus-in-intracerebrally-challenged-mice
#15
Huiqiang Yang, Huan Yang, Zhushi Li, Lina Liu, Wei Wang, Ting He, Fengming Fan, Yan Sun, Jie Liu, Yuhua Li, Xianwu Zeng
Yellow fever (YF) is an acute viral haemorrhagic disease caused by the yellow fever virus (YFV), which remains a potential threat to public health. The live-attenuated YF vaccine (17D strain) is a safe and highly effective measure against YF. However, increasing adverse events have been associated with YF vaccinations in recent years; thus, safer, alternative vaccines are needed. In this study, using the Japanese encephalitis live vaccine strain SA14-14-2 as a backbone, a novel chimeric virus was constructed by replacing the pre-membrane (prM) and envelope (E) genes with their YFV 17D counterparts...
April 25, 2018: Vaccine
https://www.readbyqxmd.com/read/29577655/first-insights-into-puumala-orthohantavirus-circulation-in-a-rodent-population-in-alsace-france
#16
E Monchatre-Leroy, S Murri, G Castel, D Calavas, F Boué, V Hénaux, P Marianneau
In-depth knowledge on the mechanisms that maintain infection by a zoonotic pathogen in an animal reservoir is the key to predicting and preventing transmission to humans. The Puumala orthohantavirus (PUUV), the most prevalent orthohantavirus in Western Europe, causes a mild form of haemorrhagic fever with renal syndrome (HFRS) in humans. In France, this endemic illness affects the north-eastern part of the country. We conducted a 4-year capture-mark-recapture study in a bank vole population, combined with molecular analyses, to explore the epidemiological situation of PUUV in Alsace, a French region where human cases have occurred, but for which no studies have been conducted on this reservoir host...
March 25, 2018: Zoonoses and Public Health
https://www.readbyqxmd.com/read/29565243/ictv-virus-taxonomy-profile-asfarviridae
#17
Covadonga Alonso, Manuel Borca, Linda Dixon, Yolanda Revilla, Fernando Rodriguez, Jose M Escribano, Ictv Report Consortium
The family Asfarviridae includes the single species African swine fever virus, isolates of which have linear dsDNA genomes of 170-194 kbp. Virions have an internal core, an internal lipid membrane, an icosahedral capsid and an outer lipid envelope. Infection of domestic pigs and wild boar results in an acute haemorrhagic fever with transmission by contact or ingestion, or by ticks of the genus Ornithodoros. Indigenous pigs act as reservoirs in Africa, where infection is endemic, and from where introductions occur periodically to Europe...
March 22, 2018: Journal of General Virology
https://www.readbyqxmd.com/read/29532238/is-the-brain-spared-in-crimean-congo-haemorrhagic-fever-an-mr-swi-study-to-reveal-cns-involvement
#18
Bilge Öztoprak, İbrahim Öztoprak, Aynur Engin
OBJECTIVES: The aim of this prospective study is to investigate the central nervous system involvement in Crimean-Congo haemorrhagic fever (CCHF) with magnetic resonance imaging (MRI) in conjunction with clinical and laboratory findings. METHODS: Between July 2015 and August 2016, 36 patients with CCHF were undergone brain MRI including SWI. Two MRIs, one at the time of admission and the second in the convalescent period, were performed for each patient in order to see if there is any sign of central nervous system (CNS) involvement, especially in terms of intracranial haemorrhage or viral encephalitis...
March 12, 2018: European Radiology
https://www.readbyqxmd.com/read/29523497/clinical-and-laboratory-predictors-of-lassa-fever-outcome-in-a-dedicated-treatment-facility-in-nigeria-a-retrospective-observational-cohort-study
#19
Peter Okokhere, Andres Colubri, Chukwuemeka Azubike, Christopher Iruolagbe, Omoregie Osazuwa, Shervin Tabrizi, Elizabeth Chin, Sara Asad, Ehi Ediale, Mojeed Rafiu, Donatus Adomeh, Ikponmwosa Odia, Rebecca Atafo, Chris Aire, Sylvanus Okogbenin, Meike Pahlman, Beate Becker-Ziaja, Danny Asogun, Terrence Fradet, Ben Fry, Stephen F Schaffner, Christian Happi, George Akpede, Stephan Günther, Pardis C Sabeti
BACKGROUND: Lassa fever is a viral haemorrhagic disease endemic to west Africa. No large-scale studies exist from Nigeria, where the Lassa virus (LASV) is most diverse. LASV diversity, coupled with host genetic and environmental factors, might cause differences in disease pathophysiology. Small-scale studies in Nigeria suggest that acute kidney injury is an important clinical feature and might be a determinant of survival. We aimed to establish the demographic, clinical, and laboratory factors associated with mortality in Nigerian patients with Lassa fever, and hypothesised that LASV was the direct cause of intrinsic renal damage for a subset of the patients with Lassa fever...
March 6, 2018: Lancet Infectious Diseases
https://www.readbyqxmd.com/read/29509132/the-protective-effect-and-diagnostic-performance-of-nox-5-in-crimean-congo-haemorrhagic-fever-patients
#20
Seyit Ali Büyüktuna, Halef Okan Doğan, Mehmet Bakir, Nazif Elaldi, Mustafa Gökhan Gözel, Aynur Engin
INTRODUCTION: Crimean-Congo haemorrhagic fever (CCHF) is an acute viral haemorrhagic disease. Reactive oxygen species that are mainly generated by the nicotinamide adenine dinucleotide phosphate (NADPH) oxidase (NOX) enzyme family have a pivotal role in the pathophysiology of many diseases. The serum levels of NOX isoforms in patients with CCHF have yet to be assessed. METHODS: This prospective study was conducted at Cumhuriyet University, Turkey. Only patients with CCHF confirmed by the National Reference Virology Laboratory were enrolled in the study...
April 2018: Journal of Medical Microbiology
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