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https://www.readbyqxmd.com/read/29720921/disulfiram-like-reaction-involving-ceftriaxone-in-a-pediatric-patient
#1
Stephen M Small, Rachel S Bacher, Sheridan A Jost
Several medications have been shown to cause disulfiram-like reactions in patients concomitantly exposed to ethanol, including specific cephalosporin antibiotics that possess a methylthiotetrazole substituent. Within the cephalosporin class, there are few reports of disulfiram-like reactions with ceftriaxone. This case report is the first to involve a pediatric patient, and it describes a mild but likely disulfiram-like reaction manifesting as facial flushing in an 8-year-old male upon receiving a ceftriaxone infusion preceded by a dose of prednisolone elixir (5% ethanol by volume) for presumed community-acquired pneumonia thought to be complicated by an asthma exacerbation...
March 2018: Journal of Pediatric Pharmacology and Therapeutics: JPPT: the Official Journal of PPAG
https://www.readbyqxmd.com/read/29629955/how-to-manage-food-dependent-exercise-induced-anaphylaxis-fdeia
#2
Tomoyuki Asaumi, Motohiro Ebisawa
PURPOSE OF REVIEW: In recent years, the number of reports on food-dependent exercise-induced anaphylaxis (FDEIA) has been increasing. This review aims to describe the standard management of FDEIA including provocation tests and identify the issues that remain unclear. RECENT FINDINGS: Provocation tests with aspirin for FDEIA enable us to confirm the definitive diagnosis and to make differential diagnosis. In some cases, FDEIA symptoms can be induced by aspirin and the causative food without exercise...
June 2018: Current Opinion in Allergy and Clinical Immunology
https://www.readbyqxmd.com/read/29603274/can-the-epoxides-of-cinnamyl-alcohol-and-cinnamal-show-new-cases-of-contact-allergy
#3
REVIEW
Lina Hagvall, Ida B Niklasson, Kristina Luthman, Ann-Therese Karlberg
BACKGROUND: Cinnamyl alcohol is considered to be a prohapten and prehapten with cinnamal as the main metabolite. However, many individuals who are allergic to cinnamyl alcohol do not react to cinnamal. Sensitizing epoxides of cinnamyl alcohol and cinnamal have been identified as metabolites and autoxidation products of cinnamyl alcohol. OBJECTIVE: To investigate the clinical relevance of contact allergy to epoxycinnamyl alcohol and epoxycinnamal. METHODS: Irritative effects of the epoxides were investigated in 12 dermatitis patients...
March 30, 2018: Contact Dermatitis
https://www.readbyqxmd.com/read/29578626/both-children-and-adult-patients-with-difficult-to-treat-atopic-dermatitis-have-high-prevalences-of-concomitant-allergic-contact-dermatitis-and-are-frequently-polysensitized
#4
M Boonstra, T Rustemeyer, M A Middelkamp-Hup
BACKGROUND: Concomitant allergic contact dermatitis (ACD) has been described as a possible cause of atopic dermatitis (AD) becoming difficult-to-treat. However, contact sensitization in this patient group has barely been studied. OBJECTIVE: To study the occurrence of ACD in a population of difficult-to-treat AD children and adults. METHODS: Clinical and patch test information of 48 patients with difficult-to-treat AD unresponsive to conventional out-patient treatments was gathered retrospectively...
March 26, 2018: Journal of the European Academy of Dermatology and Venereology: JEADV
https://www.readbyqxmd.com/read/29485033/the-x-y-factor-females-and-males-with-urologic-chronic-pelvic-pain-syndrome-present-distinct-clinical-phenotypes
#5
Gregory William Hosier, R Christopher Doiron, Victoria Tolls, J Curtis Nickel
INTRODUCTION: Urological chronic pelvic pain syndrome (UCPPS) in females is often attributed to the bladder (interstitial cystitis/bladder pain syndrome), while UCPPS in males is often attributed to the prostate (chronic prostatitis/chronic pelvic pain syndrome). However, there is increasing awareness that bladder pain plays a role in both males and females and the degree of overlap of clinical characteristics in males and females with UCPPS is not well known. Our objective was to compare clinical phenotypes of females and males with UCPPS...
February 23, 2018: Canadian Urological Association Journal, Journal de L'Association des Urologues du Canada
https://www.readbyqxmd.com/read/29477569/a-multicenter-evaluation-of-diagnosis-and-management-of-omega-5-gliadin-allergy-also-known-as-wheat-dependent-exercise-induced-anaphylaxis-in-132-adults
#6
Lucinda Kennard, Iason Thomas, Krzysztof Rutkowski, Vian Azzu, Patrick F K Yong, Bogusia Kasternow, Hannah Hunter, Naeema M O Cabdi, Alla Nakonechna, Annette Wagner
BACKGROUND: Omega-5 gliadin allergy (also known as wheat-dependent exercise-induced anaphylaxis) is a rare allergy to wheat that often presents with intermittent severe anaphylaxis in the context of a cofactor, such as exercise. OBJECTIVE: To undertake a detailed clinical characterization of the largest cohort of patients with omega-5 gliadin allergy to date. METHODS: We retrospectively analyzed the demographic characteristics, presentation, investigation, and management of 132 patients presenting with omega-5 gliadin allergy in 4 UK centers...
March 1, 2018: Journal of Allergy and Clinical Immunology in Practice
https://www.readbyqxmd.com/read/29468577/allergy-preventive-effects-of-linarinic-acid-and-its-tetrahydropyrrolo-2-1-b-quinazoline-derivatives-isolated-from-linaria-vulgaris
#7
Chao Ma, Naoko Higashi, Kyoko Ishiguro, Ying Zhao, Linkui Zhang, Chenwen Zhao, Maosheng Cheng, Hisae Oku
Linarinic acid, (-)-1,2,3,9-tetrahydropyrrolo[2,1-b]quinazoline-1-carboxylic acid (4a), was isolated from the ethanol extract of Linaria vulgaris Mill. In our previous study, a series of tetrahydropyrrolo[2,1-b]quinazoline derivatives 4b, 4c, 5a, 5b, 6a and 6b that were structurally related to 4a and evaluated as neuroprotective agents were synthesized. The aim of the present study was to investigate the novel features of these compounds. We examined their allergy-preventive effects using an in vivo assay system we developed previously, that monitors a decrease in blood flow in the tail vein of mice subjected to sensitization with hen egg-white lysozyme...
March 2018: Journal of Natural Medicines
https://www.readbyqxmd.com/read/29443762/incidence-and-risk-factors-for-surgical-site-infection-after-open-reduction-and-internal-fixation-of-ankle-fracture-a-retrospective-multicenter-study
#8
MULTICENTER STUDY
Yaning Sun, Huijuan Wang, Yuchao Tang, Haitao Zhao, Shiji Qin, Lihui Xu, Zhiyong Xia, Fengqi Zhang
Information on surgical site infection (SSI) after surgical treatment of ankle fracture is limited and remains controversial. The purpose of the present study was to determine the incidence and risk factors for SSI after open reduction and internal fixation (ORIF) of ankle fracture. Patients who underwent ORIF for ankle fracture at 3 centers between January 2015 and December 2016 were included. The potential risk factors for SSI included demographic variables, including age, sex, body mass index (BMI), hypertension, diabetes mellitus, heart disease, smoking, and excessive alcohol intake; blood test variables including preoperative white blood cell count, neutrophil count, red blood cell count, hemoglobin, total protein, albumin and globulin; injury- and surgery-related variables, including duration of operation (minutes), intraoperative blood loss, surgeon level, fracture site, accompanied dislocation, use of a drainage tube, and antibiotic use...
February 2018: Medicine (Baltimore)
https://www.readbyqxmd.com/read/29390453/spontaneous-rupture-of-the-urinary-bladder-caused-by-eosinophilic-cystitis-in-a-male-after-binge-drinking-a-case-report
#9
Xiaowen Zhang, Guangyuan Zhang, Lei Zhang, Chao Sun, Ning Liu, Ming Chen
INTRODUCTION: Spontaneous rupture of the urinary bladder is a rare, difficult to diagnose surgical emergency with a high mortality, there are many causes for spontaneous rupture of the urinary bladder, but we only found 2 reports on this condition in our literature search. A 36-year-old male patient was admitted with "whole abdominal pain associated with hematuria for 5 hours." Our patient did not have a history of definite allergy, but a long-term history of alcohol abuse. This patient was followed up for 1 year, and the cystoscopy recheck showed that the bladder lesion had healed...
December 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/29361812/associations-between-atopic-dermatitis-and-risk-of-gastric-cancer-a-nationwide-population-based-study
#10
Sehee Jo, Tae Jun Kim, Hyuk Lee, Yang Won Min, Byung Hoon Min, Jun Haeng Lee, Hee Jung Son, Poong Lyul Rhee, Sun Young Baek, Sun Woo Kim, Jae J Kim
Background/Aims: Epidemiologic and clinical data indicate that allergies may be associated with reduced risks for several cancers; however, to date, only a few studies have examined the associations between allergies and gastric cancer. This study aimed to examine the associations between allergies and gastric cancer using a large population-based dataset. Methods: This cross-sectional study obtained data from the Korea National Health and Nutrition Examination Survey between 2010 and 2014, involving a total of 24,089 participants...
January 25, 2018: Korean Journal of Gastroenterology, Taehan Sohwagi Hakhoe Chi
https://www.readbyqxmd.com/read/29318645/endometriosis-increased-the-risk-of-bladder-pain-syndrome-interstitial-cystitis-a-population-based-study
#11
Chia-Chang Wu, Shiu-Dong Chung, Herng-Ching Lin
OBJECTIVE: Previous studies have suggested an association between bladder pain syndrome/interstitial cystitis (BPS/IC) and endometriosis. However, no nation-wide population study has yet reported an association between them. In this study, we examined the risk of BPS/IC among subjects with endometriosis during a 3-year follow-up in Taiwan using a population-based dataset. STUDY DESIGN: This study comprised 9191 subjects with endometriosis, and 27 573 subjects randomly selected as controls...
January 10, 2018: Neurourology and Urodynamics
https://www.readbyqxmd.com/read/29314003/atopic-allergic-conditions-and-pancreatic-cancer-risk-results-from-the-multiethnic-cohort-study
#12
Brian Z Huang, Loic Le Marchand, Christopher A Haiman, Kristine R Monroe, Lynne R Wilkens, Zuo-Feng Zhang, Veronica Wendy Setiawan
Previous case-control studies have suggested that atopic allergic conditions (AACs) are inversely associated with pancreatic cancer, but this relationship has not been supported in many prospective settings. In this study, we investigated the influence of AACs (asthma, hay fever, or allergy) and the treatment of these conditions on pancreatic cancer risk among participants of the Multiethnic Cohort Study (MEC). AACs and antihistamine use were assessed via a baseline questionnaire when participants joined the MEC in 1993-1996...
May 15, 2018: International Journal of Cancer. Journal International du Cancer
https://www.readbyqxmd.com/read/29201800/effect-of-different-sedation-regimes-on-cognitive-functions-in-colonoscopy
#13
Perihan Ekmekçi, Gulbanu Erkan, Hakan Yilmaz, Baturay K Kazbek, Ulku C Köksoy, Güler Doganay, Doganay Filiz Tüzüner
Aim: To compare the effects of propofol/remifentanil and meperidine/midazolam on postprocedure cognitive function. Materials and methods: A total of 100 American Society of Anesthesiologists (ASA) score I to III patients undergoing elective colonoscopy were taken into the study and divided into two groups. Exclusion criteria were patient refusal, mini mental test (MMT) <26, The Amsterdam Preoperative Anxiety and Information Scale (APAIS) >10, advanced cardiopulmonary or psychiatric disease, chronic alcohol abuse, morbid obesity, and known allergy to study drugs...
July 2017: Euroasian journal of hepato-gastroenterology
https://www.readbyqxmd.com/read/29133223/phenotypical-differences-of-childhood-and-adult-onset-atopic-dermatitis
#14
Jonathan I Silverberg, Paras P Vakharia, Rishi Chopra, Ryan Sacotte, Neha Patel, Supriya Immaneni, Takeisha White, Robert Kantor, Derek Y Hsu
BACKGROUND: Little is known about adult-onset atopic dermatitis (AD). OBJECTIVE: To determine the associations and clinical characteristics of adult-onset AD. METHODS: A prospective study of 356 adults with AD (age ≥18 years) was performed using standardized questionnaires and examination. AD severity was assessed using the Patient-Oriented Eczema Measure, Eczema Area and Severity Index, Scoring Atopic Dermatitis, body surface area, and numeric rating scale for itch and sleeplessness...
November 10, 2017: Journal of Allergy and Clinical Immunology in Practice
https://www.readbyqxmd.com/read/29114901/allergic-contact-dermatitis-caused-by-calcipotriol
#15
Liesbeth Gilissen, Sara Huygens, An Goossens
BACKGROUND: Calcipotriol, a synthetic vitamin D analogue, is widely used for the topical treatment of psoriasis. It often causes irritant reactions, whereas allergic contact dermatitis has less commonly been reported. OBJECTIVES: To report on 6 patients (among them an 11-year-old child) who presented with eczematous lesions complicating pre-existing dermatitis, observed in our tertiary referral patch test clinic between 2004 and 2016. METHODS: Patch tests were performed with the commercial preparation used by the patients and/or its ingredients, including calcipotriol (2 or 10 µg/ml in isopropyl alcohol), according to ESCD patch test guidelines...
February 2018: Contact Dermatitis
https://www.readbyqxmd.com/read/28991556/a-58-year-old-woman-with-pneumonia-and-gram-negative-diplococci
#16
Giuseppe Famularo, Pasquale Sordillo, Alessandro Stasolla, Maria Gabriella Parisi
A 58-year-old woman with COPD, cor pulmonale, diabetes, and hypertension had a productive cough of greenish and purulent sputum, low-grade fever, and shortness of breath. Medications were metformin, losartan, cholecalciferol, folic acid, a multivitamin, fluticasone by inhalation, and, as needed, ipratropium by inhalation. She lived alone and worked as a physician, had received that year's seasonal influenza vaccine, was a heavy smoker, did not drink alcohol or use illicit drugs, and had no personal or family history of allergy and autoimmunity...
October 2017: Chest
https://www.readbyqxmd.com/read/28940210/contact-allergy-to-lanolin-temporal-changes-in-prevalence-and-association-with-atopic-dermatitis
#17
Marloes Fransen, Line E K Overgaard, Jeanne D Johansen, Jacob P Thyssen
BACKGROUND: Lanolin has been tested as lanolin alcohols (30% pet.) in baseline patch test series since 1969, and this has shown clinically relevant allergic contact dermatitis cases. OBJECTIVES: To investigate the temporal development of lanolin allergy (i.e. positive reaction to lanolin alcohols and/or Amerchol™ L-101), and the association between contact allergy to lanolin and patient characteristics from the MOAHLFA index. METHODS: A retrospective observational study of consecutively patch tested dermatitis patients (n = 9577) between 1 January 2004 and 31 December 2015 with lanolin alcohols 30% pet...
January 2018: Contact Dermatitis
https://www.readbyqxmd.com/read/28895387/chaenomeles-%C3%A2-health-promoting-benefits
#18
REVIEW
Katarzyna Watychowicz, Katarzyna Janda, Karolina Jakubczyk, Jolanta Wolska
Chaenomeles is a genus of deciduous spiny in the family of Rosaceae (Pomoideae subfamily). For centuries, the plant was used for a treatment of anemia, rheumatism, gout and cardiovascular diseases. The chemical composition studies of Chaenomeles showed the presence of many biologically active compounds, such as: phenolic compounds, organic acids, terpenoids, alcohols, ketones or aldehydes. Fruit of Chaenomeles has the largest applying potential due to extensive use of medicinal and high concentration of vitamin C...
2017: Roczniki Państwowego Zakładu Higieny
https://www.readbyqxmd.com/read/28796698/hormone-therapy-use-in-the-canadian-longitudinal-study-on-aging-a-cross-sectional-analysis
#19
Christy Costanian, Heather Edgell, Chris I Ardern, Hala Tamim
OBJECTIVE: The aim of the study was to assess the prevalence and factors associated with hormone therapy (HT) use among Canadian women. METHODS: Baseline data from the Tracking cohort of the Canadian Longitudinal Study on Aging (CLSA) was used for this analysis. The main outcome was HT use among women aged 45-85 years, defined as current, past, and never users. Multinomial logistic regression models were used to examine the differences between current, past, and never HT users in terms of sociodemographic, health behavior, and health-related variables...
January 2018: Menopause: the Journal of the North American Menopause Society
https://www.readbyqxmd.com/read/28761935/the-skin-microbiome-of-cohabiting-couples
#20
Ashley A Ross, Andrew C Doxey, Josh D Neufeld
Distinct microbial communities inhabit individuals as part of the human skin microbiome and are continually shed to the surrounding environment. Microbial communities from 17 skin sites of 10 sexually active cohabiting couples (20 individuals) were sampled to test whether cohabitation impacts an individual's skin microbiome, leading to shared skin microbiota among partner pairs. Amplified 16S rRNA genes of bacteria and archaea from a total of 340 skin swabs were analyzed by high-throughput sequencing, and the results demonstrated that cohabitation was significantly associated with microbial community composition, although this association was greatly exceeded by characteristics of body location and individuality...
July 2017: MSystems
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