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https://www.readbyqxmd.com/read/28069072/pansaid-paracetamol-and-nsaid-in-combination-study-protocol-for-a-randomised-trial
#1
Kasper Højgaard Thybo, Daniel Hägi-Pedersen, Jørn Wetterslev, Jørgen Berg Dahl, Henrik Morville Schrøder, Hans Henrik Bülow, Jan Gottfrid Bjørck, Ole Mathiesen
BACKGROUND: Effective postoperative pain management is essential for the rehabilitation of the surgical patient. No 'gold standard' exists after total hip arthroplasty (THA) and combinations of different nonopioid medications are used with virtually no evidence for additional analgesic efficacy compared to monotherapy. The objective of this trial is to investigate the analgesic effects and safety of paracetamol and ibuprofen alone and in combination in different dosages after THA. METHODS: PANSAID is a placebo-controlled, parallel four-group, multicentre trial with centralised computer-generated allocation sequence and allocation concealment and with varying block size and stratification by site...
January 10, 2017: Trials
https://www.readbyqxmd.com/read/28005962/health-related-factors-associated-with-discrepancies-between-children-s-potential-and-attained-secondary-school-level-a-longitudinal-study
#2
Iris van der Heide, Ulrike Gehring, Gerard H Koppelman, Alet H Wijga
OBJECTIVES: This longitudinal study examines children's health-related characteristics in relation to discrepancies between their educational potential assessed by a cognitive test in primary school at age 11 and their attained secondary school level at age 14. METHODS: Data were used from 1510 participants of the Dutch PIAMA (Prevention and Incidence of Asthma and Mite Allergy) birth cohort. Multiple multinomial logistic regression analyses were used to estimate the associations between indicators of physical health, psychosocial health, lifestyle, sleeping patterns and stressful life events and attending a higher or lower level of secondary education than indicated by the cognitive test...
2016: PloS One
https://www.readbyqxmd.com/read/27999767/antimicrobial-efficacy-of-the-combination-of-chlorhexidine-digluconate-and-dexpanthenol
#3
Axel Kramer, Ojan Assadian, Torsten Koburger-Janssen
Objective: The objective of this standardised experimental study was to investigate the antimicrobial efficacy of the combination of chlorhexidine digluconate (CHX) and the anti-inflammatory pro-vitamin dexpanthenol, which stimulates wound-healing, in the form of Bepanthen(®) Antiseptic Wound Cream, in order to rule out possible antagonistic combination effects of CHX and the alcohol analogue of pantothenic acid (vitamin B5) dexpanthenol. Method: Testing was carried out using the quantitative suspension test at conditions simulating wound bio-burden...
2016: GMS Hygiene and Infection Control
https://www.readbyqxmd.com/read/27980774/cofactors-in-allergic-reactions-to-food-physical-exercise-and-alcohol-are-the-most-important
#4
Astrid Versluis, Harmieke van Os-Medendorp, Astrid G Kruizinga, W Marty Blom, Geert F Houben, André C Knulst
INTRODUCTION: Involvement of cofactors, like physical exercise, alcohol consumption and use of several types of medication, are associated with more severe food allergic symptoms. However, there is limited evidence on how often cofactors play a role in food allergic reactions. The study aimed to get more insight into the frequency of exposure to cofactors and how often cofactors are associated with more severe symptoms in food allergic patients. METHODS: A questionnaire was completed by patients visiting the Allergology outpatient clinic...
December 2016: Immunity, Inflammation and Disease
https://www.readbyqxmd.com/read/27959728/effect-of-hiv-antibody-vrc01-on-viral-rebound-after-treatment-interruption
#5
MULTICENTER STUDY
Katharine J Bar, Michael C Sneller, Linda J Harrison, J Shawn Justement, Edgar T Overton, Mary E Petrone, D Brenda Salantes, Catherine A Seamon, Benjamin Scheinfeld, Richard W Kwan, Gerald H Learn, Michael A Proschan, Edward F Kreider, Jana Blazkova, Mark Bardsley, Eric W Refsland, Michael Messer, Katherine E Clarridge, Nancy B Tustin, Patrick J Madden, KaSaundra Oden, Sijy J O'Dell, Bernadette Jarocki, Andrea R Shiakolas, Randall L Tressler, Nicole A Doria-Rose, Robert T Bailer, Julie E Ledgerwood, Edmund V Capparelli, Rebecca M Lynch, Barney S Graham, Susan Moir, Richard A Koup, John R Mascola, James A Hoxie, Anthony S Fauci, Pablo Tebas, Tae-Wook Chun
Background The discovery of potent and broadly neutralizing antibodies (bNAbs) against human immunodeficiency virus (HIV) has made passive immunization a potential strategy for the prevention and treatment of HIV infection. We sought to determine whether passive administration of VRC01, a bNAb targeting the HIV CD4-binding site, can safely prevent or delay plasma viral rebound after the discontinuation of antiretroviral therapy (ART). Methods We conducted two open-label trials (AIDS Clinical Trials Group [ACTG] A5340 and National Institutes of Health [NIH] 15-I-0140) of the safety, side-effect profile, pharmacokinetic properties, and antiviral activity of VRC01 in persons with HIV infection who were undergoing interruption of ART...
November 24, 2016: New England Journal of Medicine
https://www.readbyqxmd.com/read/27940979/disparities-in-the-context-of-opportunities-for-cancer-prevention-in-early-life
#6
Greta M Massetti, Cheryll C Thomas, Kathleen R Ragan
Persistent health disparities are a major contributor to disproportionate burden of cancer for some populations. Health disparities in cancer incidence and mortality may reflect differences in exposures to risk factors early in life. Understanding the distribution of exposures to early life risk and protective factors for cancer across different populations can shed light on opportunities to promote health equity at earlier developmental stages. Disparities may differentially influence risk for cancer during early life and create opportunities to promote health equity...
November 2016: Pediatrics
https://www.readbyqxmd.com/read/27931299/association-of-allergy-immunology-and-obstructive-sleep-apnea
#7
Charles J Calais, Brian D Robertson, Douglas E Beakes
Obstructive sleep apnea (OSA) is characterized by repetitive upper airway collapse that results in nonrefreshing sleep, excessive daytime sleepiness, and, ultimately, adverse consequences on quality of life, the cardiovascular system, and neurocognitive performance. OSA has traditionally been linked to body habitus (obesity and increased neck circumference), racial demographics, alcohol, tobacco, and sedative use. Numerous other conditions are linked to OSA, which may have clinical relevance. Specifically, asthma and nasal obstructive syndromes, e...
November 2016: Allergy and Asthma Proceedings:
https://www.readbyqxmd.com/read/27886390/green-yellow-and-red-risk-perception-in-everyday-life-a-communication-tool
#8
A Stensgaard, A DunnGalvin, D Nielsen, M Munch, C Bindslev-Jensen
BACKGROUND: Adolescents have the highest risk for food allergy-related fatalities. Our main aim was to investigate the level of risk in everyday social situations as perceived by adolescents/young adults with peanut allergy, their families and their friends. METHODS: The web-based 'Colours Of Risks' (COR) questionnaire was completed by 70 patients (aged 12-23 years), 103 mothers and fathers, 31 siblings (aged 12-26 years), and 42 friends (aged 12-24 years). COR deals with six main contexts (home, school/university, work, visiting/social activities, special occasions/parties, and vacations), each with 1-12 items...
November 25, 2016: Allergy
https://www.readbyqxmd.com/read/27649350/contact-sensitization-to-emulsifying-agents-an-underrated-issue
#9
Monica Corazza, Annarosa Virgili, Michela Ricci, Anna Bianchi, Alessandro Borghi
BACKGROUND: The evidence on the safety of topical preparations containing emulsifiers is limited. OBJECTIVES: The aims of the study were to assess (1) the prevalence of sensitization to some emulsifiers commonly found in topical products, (2) the sensitization to emulsifiers in relation to sex, age, and predisposing factors, and (3) the frequency of concomitant sensitization to other common allergens. METHODS: All consecutive patients presenting to the Allergy Unit of our Dermatological Department for allergological investigation were enrolled...
September 2016: Dermatitis
https://www.readbyqxmd.com/read/27601486/predictors-of-physical-functioning-after-total-hip-arthroplasty-a-systematic-review
#10
L D Buirs, L W A H Van Beers, V A B Scholtes, T Pastoors, S Sprague, R W Poolman
OBJECTIVE: The objective of this systematic review of the literature was to identify the predictors of functional outcome after total hip arthroplasty (THA). METHOD: A systematic literature search in Web of Science, CINAHL, EMBASE and PubMed was conducted on 23 June 2015. The articles were selected based on their quality, relevance and measurement of the predictive factor. The level of evidence of all studies was determined using the GRADE rating scheme. RESULTS: The initial search resulted in 1092 citations...
2016: BMJ Open
https://www.readbyqxmd.com/read/27590896/cannabis-sativa-allergy-looking-through-the-fog
#11
REVIEW
I I Decuyper, A L Van Gasse, N Cop, V Sabato, M A Faber, C Mertens, C H Bridts, M M Hagendorens, L De Clerck, H P Rihs, D G Ebo
IgE-mediated Cannabis (C. sativa, marihuana) allergy seems to be on the rise. Both active and passive exposure to cannabis allergens may trigger a C. sativa sensitization and/or allergy. The clinical presentation of a C. sativa allergy varies from mild to life-threatening reactions and often seems to depend on the route of exposure. In addition, sensitization to cannabis allergens can result in various cross-allergies, mostly for plant foods. This clinical entity, designated as the 'cannabis-fruit/vegetable syndrome', might also imply cross-reactivity with tobacco, natural latex and plant-food-derived alcoholic beverages...
February 2017: Allergy
https://www.readbyqxmd.com/read/27464585/contact-allergy-to-ingredients-of-topical-medications-results-of-the-european-surveillance-system-on-contact-allergies-essca-2009-2012
#12
Wolfgang Uter, Radoslaw Spiewak, Susan M Cooper, Mark Wilkinson, Javier Sánchez Pérez, Axel Schnuch, Marie-Louise Schuttelaar
PURPOSE: The aim of this study was to give an overview of the prevalence of contact allergy to active ingredients and excipients of topical medications across Europe. METHODS: Retrospective analysis of data collected by the European Surveillance System on Contact Allergies (www.essca-dc.org) with substances applied to consecutively patch tested patients, 2009-2012, in 54 departments in 12 European countries. RESULTS: In view of the varying composition of the baseline series used in the previously mentioned departments and countries, between 58 833 (lanolin alcohols) and 16 498 patients (sodium metabisulfite) were patch tested with the topical agents covered in this study...
July 28, 2016: Pharmacoepidemiology and Drug Safety
https://www.readbyqxmd.com/read/27443169/allergy-symptoms-serum-total-immunoglobulin-e-and-risk-of-head-and-neck-cancer
#13
Hsiao-Chen Liao, Shang-Yin Wu, Chun-Yen Ou, Jenn-Ren Hsiao, Jehn-Shyun Huang, Sen-Tien Tsai, Cheng-Chih Huang, Tung-Yiu Wong, Wei-Ting Lee, Ken-Chung Chen, Sheen-Yie Fang, Jiunn-Liang Wu, Tze-Ta Huang, Yuan-Hua Wu, Wei-Ting Hsueh, Chia-Jui Yen, Ming-Wei Yang, Forn-Chia Lin, Yu-Hsuan Lai, Jang-Yang Chang, Chen-Lin Lin, Yi-Hui Wang, Ya-Ling Weng, Han-Chien Yang, Yu-Shan Chen, Jeffrey S Chang
PURPOSE: Allergy symptoms have been associated with a reduced head and neck cancer (HNC) risk, while elevated blood immunoglobulin E (IgE) levels have been associated with an increased HNC risk. According to the "prophylaxis hypothesis," allergic reaction is the body's way of expelling carcinogens. IgE level may be increased by exposure to environmental carcinogens, including alcohol and cigarette smoke. We hypothesized that individuals with elevated serum IgE without allergy symptoms (i...
September 2016: Cancer Causes & Control: CCC
https://www.readbyqxmd.com/read/27436328/occupational-skin-disease-among-australian-healthcare-workers-a-retrospective-analysis-from-an-occupational-dermatology-clinic-1993-2014
#14
Claire L Higgins, Amanda M Palmer, Jennifer L Cahill, Rosemary L Nixon
BACKGROUND: Healthcare workers (HCWs) are at risk of developing occupational skin disease (OSD). OBJECTIVES: To ascertain the causes of OSD in Australian HCWs in a tertiary referral clinic. METHODS: A retrospective review was performed of patients assessed at the Occupational Dermatology Clinic in Melbourne from 1993 to 2014. RESULTS: Of 685 HCWs assessed in the clinic over a period of 22 years, 555 (81.0%) were diagnosed with OSD...
October 2016: Contact Dermatitis
https://www.readbyqxmd.com/read/27375059/chlorhexidine-avoids-skin-bacteria-recolonization-more-than-triclosan
#15
Juan H Macias, Mildred F Alvarez, Virginia Arreguin, Juan M Muñoz, Alejandro E Macias, Jose A Alvarez
BACKGROUND: We do not know whether differences exist between the residual effect of 2% chlorhexidine in 70% isopropyl alcohol when compared with 1% triclosan in 70% isopropyl alcohol. METHODS: Using an analytic, longitudinal, controlled, and comparative experimental trial, with blinded measurements, we recruited healthy, adult volunteers from the University of Guanajuato who completed a stabilization phase of skin microbiota and had no history of skin allergies...
December 1, 2016: American Journal of Infection Control
https://www.readbyqxmd.com/read/27333719/twenty-three-year-long-term-health-outcome-after-the-war-in-vukovar
#16
Dubravko Habek, Tatjana Dujaković, Jasna Cerkez Habek, Ivana Jurković
Results of the first research of this kind on the 23-year long-term outcome in children born during the war in Vukovar are presented. This retrospective clinical study surveyed the potential 23-year long-term consequences and morbidity of children born between May 1, 1991 and November 19, 1991, during the siege and occupation of Vukovar. Data were obtained from women having delivered their babies in that period and from delivery protocols of the Department of Gynecology and Obstetrics, Vukovar County Hospital...
March 2016: Acta Clinica Croatica
https://www.readbyqxmd.com/read/27281158/in-situ-metabolism-of-cinnamyl-alcohol-in-reconstructed-human-epidermis-new-insights-into-the-activation-of-this-fragrance-skin-sensitizer
#17
Eric Moss, Camille Debeuckelaere, Valérie Berl, Karim Elbayed, François-Marie Moussallieh, Izzie-Jacques Namer, J-P Lepoittevin
Chemical modification of epidermal proteins by skin sensitizers is the molecular event which initiates the induction of contact allergy. However, not all chemical skin allergens react directly as haptens with epidermal proteins but need either a chemical (prehaptens) or metabolic (prohaptens) activation step to become reactive. Cinnamyl alcohol has been considered a model prohapten, as this skin sensitizer has no intrinsic reactivity. Therefore, the prevailing theory is that cinnamyl alcohol is enzymatically oxidized into the protein-reactive cinnamaldehyde, which is the sensitizing agent...
July 18, 2016: Chemical Research in Toxicology
https://www.readbyqxmd.com/read/27278127/gene-disease-association-with-human-ifnl-locus-polymorphisms-extends-beyond-hepatitis-c-virus-infections
#18
REVIEW
S Chinnaswamy
Interferon (IFN) lambda (IFN-λ or type III IFN) gene polymorphisms were discovered in the year 2009 to have a strong association with spontaneous and treatment-induced clearance of hepatitis C virus (HCV) infection in human hosts. This landmark discovery also brought renewed interest in type III IFN biology. After more than half a decade since this discovery, we now have reports that show that genetic association of IFNL gene polymorphisms in humans is not limited only to HCV infections but extends beyond, to include varied diseases such as non-alcoholic fatty liver disease, allergy and several other viral diseases including that caused by the human immunodeficiency virus...
July 2016: Genes and Immunity
https://www.readbyqxmd.com/read/27264293/benzyl-alcohol-allergy-mimicking-corticosteroid-allergy
#19
Minna E Kubin, Riitta Riekki
No abstract text is available yet for this article.
July 2016: Contact Dermatitis
https://www.readbyqxmd.com/read/27221300/-testing-of-the-composition-of-e-cigarette-liquids-manufacturer-declared-vs-true-contents-in-a-selected-series-of-products
#20
Małgorzata Kucharska, Wiktor Wesołowski, Sławomir Czerczak, Renata Soćko
BACKGROUND: Electronic cigarettes are currently in common use. However, in Poland there is no specific legislation governing the sale of these products. At the same time, no information has been made public about the hazards e-cigarettes pose to the users and bystanders - passive smokers. The aim of the study was to determine the qualitative composition of the analyzed liquid, which is an essential element of regulating the distribution of such cigarettes. MATERIAL AND METHODS: Under this study the method for determining the composition of e-cigarette liquids was developed...
2016: Medycyna Pracy
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