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https://www.readbyqxmd.com/read/28339786/modelling-original-antigenic-sin-in-dengue-viral-infection
#1
Ryan Nikin-Beers, Stanca M Ciupe
Cross-reactive T cell responses induced by a primary dengue virus infection may contribute to increased disease severity following heterologous infections with a different virus serotype in a phenomenon known as the original antigenic sin. In this study, we developed and analyzed in-host models of T cell responses to primary and secondary dengue virus infections that considered the effect of T cell cross-reactivity in disease enhancement. We fitted the models to published patient data and showed that the overall infected cell killing is similar in dengue heterologous infections, resulting in dengue fever and dengue hemorrhagic fever...
February 27, 2017: Mathematical Medicine and Biology: a Journal of the IMA
https://www.readbyqxmd.com/read/28333935/dengue-seroprevalence-seroconversion-and-risk-factors-in-dhaka-bangladesh
#2
Parnali Dhar-Chowdhury, Kishor Kumar Paul, C Emdad Haque, Shakhawat Hossain, L Robbin Lindsay, Antonia Dibernardo, W Abdullah Brooks, Michael A Drebot
BACKGROUND: Dengue virus (DENV) activity has been reported in Dhaka, Bangladesh since the early 1960s with the greatest burden of dengue fever and dengue hemorrhagic fever cases observed in 2000. Since this time, the intensity of dengue activity has varied from year to year, and its determining factors remained relatively unknown. In light of such gaps in knowledge, the main objectives of this study were to determine the magnitude of seroprevalence and seroconversion among the surveyed population, and establish the individual/household level risk factors for the presence of DENV antibodies among all age groups of target populations in the city of Dhaka...
March 23, 2017: PLoS Neglected Tropical Diseases
https://www.readbyqxmd.com/read/28332822/screening-of-wolbachia-endosymbiont-infection-in-aedes-aegypti-mosquitoes-using-attenuated-total-reflection-mid-infrared-spectroscopy
#3
Aazam Khoshmanesh, Dale Christensen, David Perez-Guaita, Iñaki Iturbe-Ormaetxe, Scott L O'Neill, Don McNaughton, Bayden R Wood
Dengue fever is the most common mosquito transmitted viral infection afflicting humans, estimated to generate around 390 million infections each year in over 100 countries. The introduction of the endosymbiotic bacterium Wolbachia into Aedes aegypti mosquitoes has the potential to greatly reduce the public health burden of the disease. This approach requires extensive PCR (Polymerase Chain Reaction) testing of the Wolbachia-infection status of mosquitoes in areas where Wolbachia-A. aegypti are released. Here we report the first example of small organism mid-infrared spectroscopy where we have applied Attenuated Total Reflection Fourier Transform Infrared (ATR-FTIR) spectroscopy and multivariate modelling methods to determine sex, age and the presence of Wolbachia (wMel strain) in laboratory mosquitoes and sex and age in field mosquitoes...
March 23, 2017: Analytical Chemistry
https://www.readbyqxmd.com/read/28329744/antiviral-and-immunomodulatory-effects-of-norantea-brasiliensis-choisy-on-dengue-virus-2
#4
Luciana Gomes Fialho, Vagner Pereira da Silva, Sônia Regina Nogueira Ignácio Reis, Elzinandes Leal Azeredo, Maria Auxiliadora Coelho Kaplan, Maria Raquel Figueiredo, Claire Fernandes Kubelka
BACKGROUND/AIMS: Severe dengue fever is a result of exacerbated immune responses and no specific treatments are available. We evaluated the antiviral and immunomodulatory effects of Norantea brasiliensis Choisy. METHODS: Human adherent monocytes infected in vitro with dengue virus (DENV)-2 were incubated with the crude ethanol extract from leaves (NB1) or 3 derived fractions: dichloromethane (NB3), ethyl acetate (NB5), and butanolic (NB6) partitions. The antiviral and immunomodulatory activities were determined by intracellular detection of DENV antigen within monocytes and by secreted NS1 viral protein and cytokines...
March 23, 2017: Intervirology
https://www.readbyqxmd.com/read/28327810/spatial-temporal-analysis-of-dengue-deaths-identifying-social-vulnerabilities
#5
Maria do Socorro da Silva, Maria Dos Remédios Freitas Carvalho Branco, José Aquino, Rejane Christine de Sousa Queiroz, Emanuele Bani, Emnielle Pinto Borges Moreira, Maria Nilza Lima Medeiros, Zulimar Márita Ribeiro Rodrigues
INTRODUCTION: Currently, dengue fever, chikungunya fever, and zika virus represent serious public health issues in Brazil, despite efforts to control the vector, the Aedes aegypti mosquito. METHODS: This was a descriptive and ecological study of dengue deaths occurring from 2002 to 2013 in São Luis, Maranhão, Brazil. Geoprocessing software was used to draw maps, linking the geo-referenced deaths with urban/social data at census tract level. RESULTS: There were 74 deaths, concentrated in areas of social vulnerability...
January 2017: Revista da Sociedade Brasileira de Medicina Tropical
https://www.readbyqxmd.com/read/28327798/molecular-and-clinical-epidemiological-surveillance-of-dengue-virus-in-para%C3%A3-ba-northeast-brazil
#6
Isabel Cristina Guerra-Gomes, Bruna Macêdo Gois, Rephany Fonseca Peixoto, Camila Alves Oliveira, Bruna Leal Lima Maciel, Maria Izabel Ferreira Sarmento, Anna Stella Cysneiros Pachá, Josélio Maria Galvão Araújo, Ian Porto Gurgel Amaral, Tatjana Souza Lima Keesen
INTRODUCTION: Despite being the most prevalent arboviral disease worldwide, dengue has been neglected lately. However, recent epidemics of arboviruses such as Zika and chikungunya in locations throughout the world have alerted health authorities to these diseases. This study evaluated the incidence pattern of dengue, its clinical characteristics, and co-circulation of serotypes from 2007 to 2015 in Paraiba State, Northeast Brazil. METHODS: Data on dengue cases from 2007 to 2015 were extracted from clinical reports of the National System for Notifiable Diseases [Sistema Nacional de Agravos de Notificação (SINAN)] of Brazil provided by the Paraiba Health Department...
January 2017: Revista da Sociedade Brasileira de Medicina Tropical
https://www.readbyqxmd.com/read/28323496/dengue-fever-presenting-as-purtscher-like-retinopathy
#7
Luiz H Lima, Silvana Vianello, Sérgio Pimentel, Gabriel Costa de Andrade, Claudio Zett, Léo Muller, Michel E Farah, Rubens Belfort
PURPOSE: To report the fundus manifestations and spectral-domain optical coherence tomographic (SD-OCT) features of dengue fever presenting as Purtscher-like retinopathy. METHODS: Retrospective review of two cases of dengue fever. RESULTS: Color fundus photograph revealed the presence of cotton-wool spots in a Purtscher-like configuration in the posterior pole of all study eyes. SD-OCT demonstrated increased reflectivity signal in the inner retinal layers, and after a variable follow-up period, there was complete disappearance of cotton-wool spots and persistence of the hyperreflectivity signal...
March 21, 2017: Ocular Immunology and Inflammation
https://www.readbyqxmd.com/read/28320341/seasonal-patterns-of-dengue-fever-and-associated-climate-factors-in-4-provinces-in-vietnam-from-1994-to-2013
#8
Hu Suk Lee, Hung Nguyen-Viet, Vu Sinh Nam, Mihye Lee, Sungho Won, Phuc Pham Duc, Delia Grace
BACKGROUND: In Vietnam, dengue fever (DF) is still a leading cause of hospitalization. The main objective of this study was to evaluate the seasonality and association with climate factors (temperature and precipitation) on the incidences of DF in four provinces where the highest incidence rates were observed from 1994 to 2013 in Vietnam. METHODS: Incidence rates (per 100,000) were calculated on a monthly basis from during the study period. The seasonal-decomposition procedure based on loess (STL) was used in order to assess the trend and seasonality of DF...
March 20, 2017: BMC Infectious Diseases
https://www.readbyqxmd.com/read/28317866/cyclooxygenase-2-facilitates-dengue-virus-replication-and-serves-as-a-potential-target-for-developing-antiviral-agents
#9
Chun-Kuang Lin, Chin-Kai Tseng, Yu-Hsuan Wu, Chih-Chuang Liaw, Chun-Yu Lin, Chung-Hao Huang, Yen-Hsu Chen, Jin-Ching Lee
Cyclooxygenase-2 (COX-2) is one of the important mediators of inflammation in response to viral infection, and it contributes to viral replication, for example, cytomegalovirus or hepatitis C virus replication. The role of COX-2 in dengue virus (DENV) replication remains unclear. In the present study, we observed an increased level of COX-2 in patients with dengue fever compared with healthy donors. Consistent with the clinical data, an elevated level of COX-2 expression was also observed in DENV-infected ICR suckling mice...
March 20, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28316881/occurrence-of-concurrent-infections-with-multiple-serotypes-of-dengue-viruses-during-2013-2015-in-northern-kerala-india
#10
Manchala Nageswar Reddy, Ranjeet Dungdung, Lathika Valliyott, Rajendra Pilankatta
BACKGROUND: Dengue is a global human public health threat, causing severe morbidity and mortality. The occurrence of sequential infection by more than one serotype of dengue virus (DENV) is a major contributing factor for the induction of Dengue Hemorrhagic Fever (DHF) and Dengue Shock Syndrome (DSS), two major medical conditions caused by DENV infection. However, there is no specific drug or vaccine available against dengue infection. There are reports indicating the increased incidence of concurrent infection of dengue in several tropical and subtropical regions...
2017: PeerJ
https://www.readbyqxmd.com/read/28303989/frequency-of-worsening-liver-function-in-severe-dengue-hepatitis-patients-receiving-paracetamol-a-retrospective-analysis-of-hospital-data
#11
Ahsan Ali Syed, Faisal Aslam, Haris Hakeem, Faraz Siddiqui, Noreen Nasir
OBJECTIVE: To determine the frequency of worsening liver function among hospital in-patients with severe dengue hepatitis receiving paracetamol. METHODS: This retrospective study was conducted at the Department of Medicine, Aga Khan University Hospital, Karachi, and comprised records of dengue patients with severe hepatitis who received paracetamol for control of fever between June 2007 and December 2014. Alanine aminotransferase at baseline and following paracetamol administration was noted, as well as dosage and duration of paracetamol, along with participants' demographic details...
March 2017: JPMA. the Journal of the Pakistan Medical Association
https://www.readbyqxmd.com/read/28301523/assessment-of-optimal-strategies-in-a-two-patch-dengue-transmission-model-with-seasonality
#12
Jung Eun Kim, Hyojung Lee, Chang Hyeong Lee, Sunmi Lee
Emerging and re-emerging dengue fever has posed serious problems to public health officials in many tropical and subtropical countries. Continuous traveling in seasonally varying areas makes it more difficult to control the spread of dengue fever. In this work, we consider a two-patch dengue model that can capture the movement of host individuals between and within patches using a residence-time matrix. A previous two-patch dengue model without seasonality is extended by adding host demographics and seasonal forcing in the transmission rates...
2017: PloS One
https://www.readbyqxmd.com/read/28298933/circulation-of-dengue-virus-serotypes-in-the-city-of-makkah-saudi-arabia-as-determined-by-reverse-transcription-polymerase-chain-reaction
#13
Sameer R Organji, Hussein H Abulreesh, Gamal E H Osman
The present study was aimed to investigate the circulation of four dengue virus (DENV) serotypes in Makkah, Western Saudi Arabia. Blood samples were collected from 25 dengue fever-suspected patients and were subjected to molecular typing for DENV-1, DENV-2, DENV-3, and DENV-4 serotypes of dengue virus, by reverse transcription polymerase chain reaction (RT-PCR), using six sets of primers. Of the 25 samples, only six samples (24%) were found to be positive for dengue virus infection. The prevalence of DENV-1 was higher (50% of DENV-positive samples), as compared to DENV-2 (33...
2017: Canadian Journal of Infectious Diseases & Medical Microbiology
https://www.readbyqxmd.com/read/28298837/a-study-of-acute-muscle-dysfunction-with-particular-reference-to-dengue-myopathy
#14
Rajesh Verma, Vikram V Holla, Vijay Kumar, Amita Jain, Nuzhat Husain, Kiran Preet Malhotra, Ravindra Kumar Garg, Hardeep Singh Malhotra, Praveen Kumar Sharma, Neeraj Kumar
BACKGROUND: Acute myopathy is a common cause of acute motor quadriparesis which has various etiologies with different courses of illness and prognosis depending on the cause. Understanding this diversity helps us in proper approach toward diagnosis, predicting the prognosis, and possible complications and in improving the treatments that are being provided. This study was planned to study the clinical, electrophysiological, and etiological profile of patients presenting with acute myopathy...
January 2017: Annals of Indian Academy of Neurology
https://www.readbyqxmd.com/read/28296373/-the-fourth-horseman-the-yellow-fever
#15
Alfonso Vallejos-Parás, David Alejandro Cabrera-Gaytán
Dengue virus three, Chikunguya and Zika have entered the national territory through the south of the country. Cases and outbreaks of yellow fever have now been identified in the Americas where it threatens to expand. Although Mexico has a robust epidemiological surveillance system for vector-borne diseases, our country must be alert in case of its possible introduction into the national territory. This paper presents theoretical assumptions based on factual data on the behavior of yellow fever in the Americas, as well as reflections on the epidemiological surveillance of vector-borne diseases...
March 2017: Revista Médica del Instituto Mexicano del Seguro Social
https://www.readbyqxmd.com/read/28294472/knowledge-and-practice-regarding-dengue-and-chikungunya-a-cross-sectional-study-among-healthcare-workers-and-community-in-northern-tanzania
#16
Debora C Kajeguka, Rachelle E Desrochers, Rose Mwangi, Maseke R Mgabo, Michael Alifrangis, Reginald A Kavishe, Franklin W Mosha, Manisha A Kulkarni
OBJECTIVE: To investigate knowledge and prevention practices regarding dengue and chikungunya amongst community members, as well as knowledge, treatment and diagnostic practices among healthcare workers. METHOD: We conducted a cross-sectional survey with 125 community members and 125 healthcare workers from 13 health facilities in six villages in the Hai district of Tanzania. A knowledge score was generated based on participant responses to a structured questionnaire, with a score of 40 or higher (out of 80 and 50 total scores for community members and healthcare workers, respectively) indicating good knowledge...
March 13, 2017: Tropical Medicine & International Health: TM & IH
https://www.readbyqxmd.com/read/28293273/mathematical-modelling-of-immune-parameters-in-the-evolution-of-severe-dengue
#17
M K Premaratne, S S N Perera, G N Malavige, Saroj Jayasinghe
Aims. Predicting the risk of severity at an early stage in an individual patient will be invaluable in preventing morbidity and mortality caused by dengue. We hypothesized that such predictions are possible by analyzing multiple parameters using mathematical modeling. Methodology. Data from 11 adult patients with dengue fever (DF) and 25 patients with dengue hemorrhagic fever (DHF) were analyzed. Multivariate statistical analysis was performed to study the characteristics and interactions of parameters using dengue NS1 antigen levels, dengue IgG antibody levels, platelet counts, and lymphocyte counts...
2017: Computational and Mathematical Methods in Medicine
https://www.readbyqxmd.com/read/28292653/co-circulating-serotypes-in-a-dengue-fever-outbreak-differential-hematological-profiles-and-phylogenetic-relationships-among-viruses
#18
Andreia Moreira Dos Santos Carmo, Rodrigo Buzinaro Suzuki, Aline Diniz Cabral, Renata Torres da Costa, Gabriela Pena Massari, Michele Marcondes Riquena, Helio Augusto Alves Fracasso, Andre Eterovic, Arlei Marcili, Márcia Aparecida Sperança
BACKGROUND: Dengue virus, represented by four distinct, genetically diverse serotypes, is the etiologic agent of asymptomatic to severe hemorrhagic diseases. The spatiotemporal dynamics of dengue serotypes and its association to specific diseases vary among the different regions worldwide. By 2007, and in São Paulo State, Brazil, dengue-case concentration in urban centers had changed to increased incidence in small- and medium-sized towns, the case of Marília. OBJECTIVES: The aim of this article was to distinguish dengue serotypes circulating during the 2007 Marília outbreak and define their association to demographic and hematological patient profiles, as well as the phylogenetic relationships among the different viruses...
March 6, 2017: Journal of Clinical Virology: the Official Publication of the Pan American Society for Clinical Virology
https://www.readbyqxmd.com/read/28289727/seroprevalence-of-zika-virus-in-wild-african-green-monkeys-and-baboons
#19
Connor R Buechler, Adam L Bailey, Andrea M Weiler, Gabrielle L Barry, Meghan E Breitbach, Laurel M Stewart, Anna J Jasinska, Nelson B Freimer, Cristian Apetrei, Jane E Phillips-Conroy, Clifford J Jolly, Jeffrey Rogers, Thomas C Friedrich, David H O'Connor
Zika virus (ZIKV) has recently spread through the Americas and has been associated with a range of health effects, including birth defects in children born to women infected during pregnancy. Although the natural reservoir of ZIKV remains poorly defined, the virus was first identified in a captive "sentinel" macaque monkey in Africa in 1947. However, the virus has not been reported in humans or nonhuman primates (NHPs) in Africa outside Gabon in over a decade. Here, we examine ZIKV infection in 239 wild baboons and African green monkeys from South Africa, the Gambia, Tanzania, and Zambia using combinations of unbiased deep sequencing, quantitative reverse transcription-PCR (qRT-PCR), and an antibody capture assay that we optimized using serum collected from captive macaque monkeys exposed to ZIKV, dengue virus, and yellow fever virus...
March 2017: MSphere
https://www.readbyqxmd.com/read/28285970/longitudinal-study-of-thai-people-media-exposure-knowledge-and-behavior-on-dengue-fever-prevention-and-control
#20
Smith Boonchutima, Kirati Kachentawa, Manasanun Limpavithayakul, Anan Prachansri
Dengue hemorrhagic fever is transmitted through a bite by a dengue -infected Aedes aegypti mosquito. It was first reported in the mid -20th century in Thailand, and since then its epidemiology has been of great concern and has spread all across the country. The alarming incidence of dengue posed a serious threat to human health in all major cities of Thailand. This study was aimed at identifying the level of awareness of dengue fever in Thai population knowledge for prevention and control, and most importantly contribution of media in educating masses for dengue control measures...
March 9, 2017: Journal of Infection and Public Health
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