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https://www.readbyqxmd.com/read/29792154/exploration-of-hetero-aryl-derived-thienylchalcones-for-antiviral-and-anticancer-activities
#1
Vikrant Patil, Siddappa A Patil, Renukadevi Patil, Alejandro Bugarin, Kenneth Beaman, Shivaputra A Patil
BACKGROUND: Search for new antiviral and anticancer agents are essential because of the emergence of drug resistance in recent years. In continuation of our efforts in identifying the new small molecule antiviral and anticancer agents, we identified chalcones as potent antiviral and anticancer agents. OBJECTIVE: With the aim of identifying the broad acting antiviral and anticancer agents, we discovered substituted aryl/heteroaryl derived thienyl chalcones as antiviral and anticancer agents...
May 23, 2018: Medicinal Chemistry
https://www.readbyqxmd.com/read/29789369/-wolbachia-w-stri-blocks-zika-virus-growth-at-two-independent-stages-of-viral-replication
#2
M J Schultz, A L Tan, C N Gray, S Isern, S F Michael, H M Frydman, J H Connor
Mosquito-transmitted viruses are spread globally and present a great risk to human health. Among the many approaches investigated to limit the diseases caused by these viruses are attempts to make mosquitos resistant to virus infection. Coinfection of mosquitos with the bacterium Wolbachia pipientis from supergroup A is a recent strategy employed to reduce the capacity for major vectors in the Aedes mosquito genus to transmit viruses, including dengue virus (DENV), Chikungunya virus (CHIKV), and Zika virus (ZIKV)...
May 22, 2018: MBio
https://www.readbyqxmd.com/read/29785478/changing-trend-of-infectious-diseases-in-nepal
#3
Shiba Kumar Rai
Many infectious/communicable diseases (IDs) are endemic in Nepal. Until a decade and half ago, IDs were the major cause of both morbidity and mortality accounting 70% for both. However, as a result of various preventive measures implemented by both the state and non-state actors, the overall IDs have shown a changing (declining) trend. The most impressive decline has been seen in the intestinal helminth infection. Though the overall burden of IDs is decreasing, several newer infectious diseases (emerging infections) namely, dengue fever, scrub typhus, influenza (H5N1 and H1N1), and others are posing a great public health problem...
2018: Advances in Experimental Medicine and Biology
https://www.readbyqxmd.com/read/29782922/dengue-chikungunya-and-zika-infections-imported-to-paris-between-2009-and-2016-characteristics-and-correlation-with-outbreaks-in-the-french-overseas-territories-of-guadeloupe-and-martinique
#4
Victor Vasquez, Elie Haddad, Alice Perignon, Stéphane Jaureguiberry, Ségolène Brichler, Isabelle Leparc-Goffart, Eric Caumes
BACKGROUND: Dengue (DV), chikungunya (CV) and Zika virus (ZV) infections are rapidly expanding across countries and diagnosed in returned travelers who represent epidemiological sentinels. French Territories of America (FTA) such as Guadeloupe and Martinique are highly touristic places and have experienced three consecutive outbreaks by such viruses in the last decade. OBJECTIVE: We evaluated how ill returned travelers could be deemed as epidemiological sentinels for these three expanding arboviral diseases during eight consecutive years...
May 18, 2018: International Journal of Infectious Diseases: IJID
https://www.readbyqxmd.com/read/29782512/regulation-of-midgut-cell-proliferation-impacts-aedes-aegypti-susceptibility-to-dengue-virus
#5
Mabel L Taracena, Vanessa Bottino-Rojas, Octavio A C Talyuli, Ana Beatriz Walter-Nuno, José Henrique M Oliveira, Yesseinia I Angleró-Rodriguez, Michael B Wells, George Dimopoulos, Pedro L Oliveira, Gabriela O Paiva-Silva
Aedes aegypti is the vector of some of the most important vector-borne diseases like dengue, chikungunya, zika and yellow fever, affecting millions of people worldwide. The cellular processes that follow a blood meal in the mosquito midgut are directly associated with pathogen transmission. We studied the homeostatic response of the midgut against oxidative stress, as well as bacterial and dengue virus (DENV) infections, focusing on the proliferative ability of the intestinal stem cells (ISC). Inhibition of the peritrophic matrix (PM) formation led to an increase in reactive oxygen species (ROS) production by the epithelial cells in response to contact with the resident microbiota, suggesting that maintenance of low levels of ROS in the intestinal lumen is key to keep ISCs division in balance...
May 21, 2018: PLoS Neglected Tropical Diseases
https://www.readbyqxmd.com/read/29780108/plasmacytoid-lymphocytes-a-diagnostic-clue-for-dengue-fever
#6
Yasuhiro Tanaka
No abstract text is available yet for this article.
May 18, 2018: Internal Medicine
https://www.readbyqxmd.com/read/29779827/zika-virus-report-from-the-task-force-on-tropical-diseases-by-the-world-federation-of-societies-of-intensive-and-critical-care-medicine
#7
Gisele Sampaio Silva, Guy A Richards, Tim Baker, Jorge Hidalgo, Juan Ignacio Silesky Jiménez, Pravin Amin
Zika fever is an acute infectious disease caused by the Zika virus (ZIKV), an RNA virus belonging to the genus Flavivirus. ZIKV can be transmitted by bites from Aedes aegypti and Aedes albopictus species, sexual activity, blood transfusion and from mother to fetus during pregnancy and delivery. A total of 50 territories and countries in the Americas had reported ZIKV infections. For those with symptoms, the presentation is similar to dengue fever with body aches, joint pain, fatigue, malaise, fever and conjunctivitis lasting up to seven days...
April 5, 2018: Journal of Critical Care
https://www.readbyqxmd.com/read/29777926/epidemiology-of-acute-febrile-illness-in-latin-america
#8
REVIEW
José Moreira, Clarisse S Bressan, Patricia Brasil, Andre M Siqueira
BACKGROUND: The causes of acute febrile illness (AFI) in Latin America (LA) are diverse and its complexity increase as the proportion of fever due to malaria decreases as control and new pathogens emerge in the region. In this context, it is important to shed light over the gaps on the epidemiological characteristics and the geographic range for many AFI aetiologies. AIMS: To review studies on community-acquired fever etiology other than malaria in LA, and to highlight knowledge gaps and challenges needing further investigation...
May 16, 2018: Clinical Microbiology and Infection
https://www.readbyqxmd.com/read/29777177/controlling-vector-borne-diseases-by-releasing-modified-mosquitoes
#9
REVIEW
Heather A Flores, Scott L O'Neill
Aedes mosquito-transmitted diseases, such as dengue, Zika and chikungunya, are becoming major global health emergencies while old threats, such as yellow fever, are re-emerging. Traditional control methods, which have focused on reducing mosquito populations through the application of insecticides or preventing breeding through removal of larval habitat, are largely ineffective, as evidenced by the increasing global disease burden. Here, we review novel mosquito population reduction and population modification approaches with a focus on control methods based on the release of mosquitoes, including the release of Wolbachia-infected mosquitoes and strategies to genetically modify the vector, that are currently under development and have the potential to contribute to a reversal of the current alarming disease trends...
May 18, 2018: Nature Reviews. Microbiology
https://www.readbyqxmd.com/read/29775680/assessing-the-effects-of-daily-commuting-in-two-patch-dengue-dynamics-a-case-study-of-cali-colombia
#10
Edwin Barrios, Sunmi Lee, Olga Vasilieva
There are many infectious diseases that can be spread by daily commuting of people and dengue fever is one of them. The absence of vaccine and irregularities in ongoing vector control programs make this disease the most frequent and persistent in many tropical and subtropical regions of the world. This paper targets to access the effects of daily commuting on dengue transmission dynamics by using a deterministic two-patch model fitted to observed data gathered in Cali, Colombia where dengue fever is highly persistent and exhibits endemo-epidemic patterns...
May 15, 2018: Journal of Theoretical Biology
https://www.readbyqxmd.com/read/29774286/biological-control-of-anopheles-darlingi-aedes-aegypti-and-culex-quinquefasciatus-larvae-using-shrimps
#11
Willian Marinho Dourado Coelho, Juliana de Carvalho Apolinário Coêlho, Katia Denise Saraiva Bresciani, Wilma Aparecida Starke Buzetti
Mosquitoes can act as vectors of important diseases such as malaria, dengue, Zika virus, yellow fever, Chikungunya and Mayaro fever, in addition to filariasis. The use of insecticides, larvicides, bed nets and repellents, besides the use of drugs as chemoprevention and the treatment of the sick are currently the pillars of the control of these vectors. We studied the biological control against of Anopheles darlingi , Aedes aegypti and Culex quinquefasciatus larvae using shrimps of the species M. pantanalense , M...
August 2017: Parasite Epidemiology and Control
https://www.readbyqxmd.com/read/29768655/let-7e-inhibits-tnf-%C3%AE-expression-by-targeting-the-methyl-transferase-ezh2-in-denv2-infected-thp-1-cells
#12
Yingke Zhang, Qianqian Zhang, Lian Gui, Yan Cai, Xiaohong Deng, Cheukfai Li, Qi Guo, Xiaoshun He, Junqi Huang
Tumor necrosis factor α (TNFα), an important inflammatory cytokine, is associated with dengue hemorrhagic fever/dengue shock syndrome (DHF/DSS), a severe pathological manifestation of dengue virus (DENV) infection. However, the regulatory mechanism of microRNA on TNFα is currently unknown. Our study showed that the TNFα expression increased immediately and then later decreased, while a marked increase for the miRNA let-7e was detected in dengue virus type 2 (DENV2)-infected peripheral blood mononuclear cells (PBMCs)...
May 16, 2018: Journal of Cellular Physiology
https://www.readbyqxmd.com/read/29768102/identification-of-dengue-and-chikungunya-cases-among-suspected-cases-of-yellow-fever-in-the-democratic-republic-of-the-congo
#13
Sheila Makiala-Mandanda, Steve Ahuka-Mundeke, Jessica L Abbate, Elisabeth Pukuta-Simbu, Justus Nsio-Mbeta, Nicolas Berthet, Eric Maurice Leroy, Pierre Becquart, Jean-Jacques Muyembe-Tamfum
For more than 95% of acute febrile jaundice cases identified through surveillance for yellow fever, a reemerging arthropod-borne viral disease, no etiological exploration is ever done. The aim of this study was to test for other arthropod-borne viruses that can induce the same symptoms in patients enrolled in the yellow fever surveillance in the Democratic Republic of the Congo (DRC). Of 652 patients included in the surveillance of yellow fever in DRC from January 2003 to January 2012, 453 patients that tested negative for yellow fever virus (YFV) immunoglobulin M (IgM) antibodies were selected for the study...
May 16, 2018: Vector Borne and Zoonotic Diseases
https://www.readbyqxmd.com/read/29764403/meteorological-factors-affecting-dengue-incidence-in-davao-philippines
#14
Jesavel A Iguchi, Xerxes T Seposo, Yasushi Honda
BACKGROUND: Dengue fever is a major public health concern in the Philippines, and has been a significant cause of hospitalizations and deaths among young children. Previous literature links climate change to dengue, and with increasingly unpredictable changing climate patterns, there is a need to understand how these meteorological variables affect dengue incidence in a highly endemic area. METHODS: Weekly dengue incidences (2011-2015) in Davao Region, Philippines were obtained from the Department of Health...
May 15, 2018: BMC Public Health
https://www.readbyqxmd.com/read/29759076/threats-of-zika-virus-transmission-for-asia-and-its-hindu-kush-himalayan-region
#15
Meghnath Dhimal, Sushma Dahal, Mandira Lamichhane Dhimal, Shiva Raj Mishra, Khem B Karki, Krishna Kumar Aryal, Ubydul Haque, Md Iqbal Kabir, Pradeep Guin, Azeem Mehmood Butt, Harapan Harapan, Qi-Yong Liu, Cordia Chu, Doreen Montag, David Alexander Groneberg, Basu Dev Pandey, Ulrich Kuch, Ruth Müller
Asia and its Hindu Kush Himalayan (HKH) region is particularly vulnerable to environmental change, especially climate and land use changes further influenced by rapid population growth, high level of poverty and unsustainable development. Asia has been a hotspot of dengue fever and chikungunya mainly due to its dense human population, unplanned urbanization and poverty. In an urban cycle, dengue virus (DENV) and chikungunya virus (CHIKV) are transmitted by Aedes aegypti and Ae. albopictus mosquitoes which are also competent vectors of Zika virus (ZIKV)...
May 15, 2018: Infectious Diseases of Poverty
https://www.readbyqxmd.com/read/29759074/dengue-fever-complicated-with-guillain-barr%C3%A3-syndrome-a-case-report-and-review-of-the-literature
#16
Chamara Dalugama, John Shelton, Mahendra Ekanayake, Indika Bandara Gawarammana
BACKGROUND: Dengue is an arboviral infection classically presenting with fever, arthralgia, headache, and rashes. It is hyperendemic in Sri Lanka and has a major impact on health. Neurological complications of dengue fever are rare but have been reported in the literature. CASE PRESENTATION: A 60-year-old Sri Lankan man presented with a history of fever, arthralgia, and generalized malaise of 2 days duration. A diagnosis of dengue was confirmed with leukopenia, thrombocytopenia, and positive NS1 antigen done on day 2 without evidence of hemoconcentration...
May 15, 2018: Journal of Medical Case Reports
https://www.readbyqxmd.com/read/29755701/role-of-cytokines-as-molecular-marker-of-dengue-severity
#17
Priyanka Sehrawat, Ashutosh Biswas, Prabhat Kumar, Paras Singla, Naveet Wig, Lalit Dar, Rita Sood
Objective: Dengue infection is a rapidly spreading vector-borne disease and is endemic in the Indian subcontinent. It has varied manifestations ranging from subclinical infection to severe fatal shock syndrome. This study aimed to estimate cytokine level in dengue patients and correlate them with dengue severity. Methods: Cases of dengue fever diagnosed in the department of medicine of our institute from July 2015 to November 2016 were included in the study. The clinical features, biochemical, hematological and radiological parameters along with cytokine levels (Interferon-gamma, Interleukin-6, and Tumour Necrosis Factor-alpha) were recorded in all patients...
2018: Mediterranean Journal of Hematology and Infectious Diseases
https://www.readbyqxmd.com/read/29753850/role-of-mitogen-activated-protein-kinase-signaling-in-the-pathogenesis-of-dengue-virus-infection
#18
REVIEW
Gopinathan Pillai Sreekanth, Pa-Thai Yenchitsomanus, Thawornchai Limjindaporn
Dengue virus (DENV) infection is a disease that is endemic to many parts of the world, and its increasing prevalence ranks it among the diseases considered to be a significant threat to public health. The clinical manifestations of DENV infection range from mild dengue fever (DF) to more severe dengue hemorrhagic fever (DHF) and dengue shock syndrome (DSS). Increased proinflammatory cytokines and vascular permeability, both of which cause organ injury, are the hallmarks of severe dengue disease. Signs of liver injury were observed in studies using hepatic cell lines, mouse models, and autopsy specimens from DENV-infected patients, and these signs substantiated the effects of inflammatory responses and hepatic cell apoptosis...
May 10, 2018: Cellular Signalling
https://www.readbyqxmd.com/read/29751873/acute-viral-hepatitis-beyond-a-b-and-c
#19
REVIEW
Venancio Avancini Ferreira Alves
From the standpoint of the surgical pathologist "hepatitis" is defined as the set of histologic patterns of lesions found in livers infected by hepatotropic viruses, by non-hepatotrophic viruses leading to liver inflammation in the context of systemic infection, or due to an autoimmune disease, drug, or toxin involving the liver. This article is centered on the histologic patterns of injury in acute viral hepatitis, encompassing the hepatotropic viruses A, B, C, D, and E and the "icteric hemorrhagic fevers" (dengue, hantavirus, yellow fever)...
June 2018: Surgical Pathology Clinics
https://www.readbyqxmd.com/read/29751761/evaluation-of-an-immunochromatography-rapid-diagnosis-kit-for-detection-of-chikungunya-virus-antigen-in-india-a-dengue-endemic-country
#20
Jaspreet Jain, Tamaki Okabayashi, Navjot Kaur, Emi Nakayama, Tatsuo Shioda, Rajni Gaind, Takeshi Kurosu, Sujatha Sunil
BACKGROUND: Chikungunya virus (CHIKV) and dengue virus (DENV) are arboviruses that share the same Aedes mosquito vector, and there is much overlap in endemic areas. In India, co-infection with both viruses is often reported. Clinical manifestations of Chikungunya fever is often confused with dengue fever because clinical symptoms of both infections are similar. It is, therefore, difficult to differentiate from those of other febrile illnesses, especially dengue fever. We previously developed a CHIKV antigen detection immunochromatography (IC) rapid diagnosis kit [1]...
May 11, 2018: Virology Journal
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