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https://www.readbyqxmd.com/read/29051182/oncogenetic-mutations-combined-with-mrd-improve-outcome-prediction-in-pediatric-t-cell-acute-lymphoblastic-leukemia
#1
Arnaud Petit, Amélie Trinquand, Sylvie Chevret, Paola Ballerini, Jean-Michel Cayuela, Nathalie Grardel, Aurore Touzart, Benoit Brethon, Hélène Lapillonne, Claudine Schmitt, Sandrine Thouvenin, Gerard Michel, Claude Preudhomme, Jean Soulier, Judith Landman-Parker, Guy Leverger, Elizabeth Macintyre, André Baruchel, Vahid Asnafi
Risk stratification in childhood T-ALL is mainly based on minimal residual disease (MRD) quantification. Whether oncogenetic mutation profiles can improve the discrimination of MRD-defined risk categories was unknown. 220 FRALLE2000T treated patients were tested retrospectively for NOTCH1/FBXW7/RAS and PTEN alterations. Patients with N/F mutation and R/P germline (GL) were defined as oncogenetic low risk (gLoR), while N/F GL and R/P GL or mutation and N/F mutation and R/P mutation were defined as high risk (gHiR)...
October 19, 2017: Blood
https://www.readbyqxmd.com/read/29049177/association-of-bmp-14-rs143383-ploymorphism-with-its-susceptibility-to-osteoarthritis-a-meta-analysis-and-systematic-review-according-to-prisma-guideline
#2
Yi Yin, Yan Wang
BACKGROUND: Osteoarthritis (OA) is a complex disease which can be caused by both environmental and genetic factors. A functional locus rs143383 of bone morphogenetic protein-14 (BMP-14) has been pointed out to be associated with OA etiology, but conflicting conclusions have been reached. To provide a more comprehensive conclusion about this issue, we performed this meta-analysis. METHODS: Relevant studies were searched from electronic databases including PubMed, Chinese National Knowledge Infrastructure, Embase, and Wanfang...
October 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/29044915/pre-discharge-and-early-post-discharge-troponin-elevation-among-patients-hospitalized-for-heart-failure-with-reduced-ejection-fraction-findings-from-the-astronaut-trial
#3
Stephen J Greene, Javed Butler, Gregg C Fonarow, Haris P Subacius, Andrew P Ambrosy, Muthiah Vaduganathan, Marco Triggiani, Scott D Solomon, Eldrin F Lewis, Aldo P Maggioni, Michael Böhm, Ovidiu Chioncel, Savina Nodari, Michele Senni, Faiez Zannad, Mihai Gheorghiade
AIMS: Troponin levels are commonly elevated among patients hospitalized for heart failure (HF), but the prevalence and prognostic significance of early post-discharge troponin elevation are unclear. This study sought to describe the frequency and prognostic value of pre-discharge and post-discharge troponin elevation, including persistent troponin elevation from the inpatient to outpatient settings. METHODS AND RESULTS: The ASTRONAUT trial (NCT00894387; http://www...
October 17, 2017: European Journal of Heart Failure
https://www.readbyqxmd.com/read/29029074/multimodality-imaging-evaluation-of-chagas-disease-an-expert-consensus-of-brazilian-cardiovascular-imaging-department-dic-and-the-european-association-of-cardiovascular-imaging-eacvi
#4
Maria Carmo P Nunes, Luigi Paolo Badano, J Antonio Marin-Neto, Thor Edvardsen, Covadonga Fernández-Golfín, Chiara Bucciarelli-Ducci, Bogdan A Popescu, Richard Underwood, Gilbert Habib, Jose Luis Zamorano, Roberto Magalhães Saraiva, Ester Cerdeira Sabino, Fernando A Botoni, Márcia Melo Barbosa, Marcio Vinicius L Barros, Eduardo Falqueto, Marcus Vinicius Simões, André Schmidt, Carlos Eduardo Rochitte, Manoel Otávio Costa Rocha, Antonio Luiz Pinho Ribeiro, Patrizio Lancellotti
Aims: To develop a document by Brazilian Cardiovascular Imaging Department (DIC) and the European Association of Cardiovascular Imaging (EACVI) to review and summarize the most recent evidences about the non-invasive assessment of patients with Chagas disease, with the intent to set up a framework for standardized cardiovascular imaging to assess cardiovascular morphologic and functional disturbances, as well as to guide the subsequent process of clinical decision-making. Methods and results: Chagas disease remains one of the most prevalent infectious diseases in Latin America, and has become a health problem in non-endemic countries...
September 25, 2017: European Heart Journal Cardiovascular Imaging
https://www.readbyqxmd.com/read/28994485/modified-risk-stratification-grouping-using-standard-clinical-and-biopsy-information-for-patients-undergoing-radical-prostatectomy-results-from-search
#5
Zachary S Zumsteg, Zinan Chen, Lauren E Howard, Christopher L Amling, William J Aronson, Matthew R Cooperberg, Christopher J Kane, Martha K Terris, Daniel E Spratt, Howard M Sandler, Stephen J Freedland
INTRODUCTION: Prostate cancer is a heterogeneous disease, and risk stratification systems have been proposed to guide treatment decisions. However, significant heterogeneity remains for those with unfavorable-risk disease. METHODS: This study included 3335 patients undergoing radical prostatectomy without adjuvant radiotherapy in the SEARCH database. High-risk patients were dichotomized into standard and very high-risk (VHR) groups based on primary Gleason pattern, percentage of positive biopsy cores (PPBC), number of NCCN high-risk factors, and stage T3b-T4 disease...
October 10, 2017: Prostate
https://www.readbyqxmd.com/read/28979718/characterisation-and-risk-assessment-of-venous-thromboembolism-in-gastrointestinal-cancers
#6
Robert L Metcalf, Eamon Al-Hadithi, Nicholas Hopley, Thomas Henry, Clare Hodgson, Antony McGurk, Wasat Mansoor, Jurjees Hasan
AIM: To characterise venous thromboembolism (VTE) in gastrointestinal cancer and assess the clinical utility of risk stratification scoring. METHODS: We performed a retrospective analysis using electronic patient records of 910 gastro-oesophageal (GO) cancer and 1299 colorectal cancer (CRC) patients referred to a tertiary cancer centre to identify the incidence of VTE, its relationship to chemotherapy and impact on survival. VTE risk scores were calculated using the Khorana index...
September 15, 2017: World Journal of Gastrointestinal Oncology
https://www.readbyqxmd.com/read/28977973/multiparametric-imaging-using-18-f-fdg-pet-ct-heterogeneity-parameters-and-functional-mri-techniques-prognostic-significance-in-patients-with-primary-advanced-oropharyngeal-or-hypopharyngeal-squamous-cell-carcinoma-treated-with-chemoradiotherapy
#7
Sheng-Chieh Chan, Nai-Ming Cheng, Chia-Hsun Hsieh, Shu-Hang Ng, Chien-Yu Lin, Tzu-Chen Yen, Cheng-Lung Hsu, Hung-Ming Wan, Chun-Ta Liao, Kai-Ping Chang, Jiun-Jie Wang
BACKGROUND: In this study, PET heterogeneity was combined with functional MRI techniques to refine the prediction of prognosis in patients with oropharyngeal or hypopharyngeal squamous cell carcinoma (OHSCC). METHODS: A total of 124 patients with primary advanced OHSCC who underwent pretreatment (18)F-FDG PET/CT, dynamic contrast-enhanced MR imaging (DCE-MRI), and diffusion-weighted MR imaging (DWI) were enrolled. Conventional and heterogeneity parameters from (18)F-FDG PET as well as perfusion parameters from DCE-MRI and diffusion parameter from DWI of primary tumors were analyzed in relation to recurrence-free survival (RFS) and overall survival (OS)...
September 22, 2017: Oncotarget
https://www.readbyqxmd.com/read/28976766/synthesis-and-assessment-of-peptide-gd-dota-conjugates-targeting-extradomain-b-fibronectin-for-magnetic-resonance-molecular-imaging-of-prostate-cancer
#8
Yajuan Li, Zheng Han, Sarah Roelle, Aidan DeSanto, Rob Sabatelle, Rebecca Schur, Zheng-Rong Lu
Contrast enhanced MRI is commonly used in imaging and treatment planning of prostate cancer. However, no tumor targeting contrast agent is commercially available for accurate detection and characterization prostate cancer with MRI. Extradomain B fibronectin (EDB-FN), an oncoprotein present in aggressive tumors, is a promising molecular target for detection and stratification of high-risk prostate cancer. In this work, we have identified four small peptides (GVK, IGK, SGV, and ZD2) specific to EDB-FN for tumor targeting...
October 4, 2017: Molecular Pharmaceutics
https://www.readbyqxmd.com/read/28967731/new-assessment-for-advanced-age-italian-study-protocol-on-the-assessment-of-surgical-risk-in-the-over-75-year-age-group
#9
Annarita Pilleri, Giampaolo Scorcu
The role of age in the risk stratification of patients candidate for non-cardiac surgery is still today an unresolved issue. European guidelines, in contrast to American guidelines, do not attribute to age an independent role in increasing the risk, and the indices for assessment of perioperative cardiovascular risk are based on studies that were carried out on middle-aged subgroups of the population without specific attention to the elderly patient. While the indices of geriatric assessment have still not yet gained a standardized role in the risk stratification of patients candidate to non-cardiac surgery, their need is becoming increasingly urgent considering the epidemiological impact of elderly patients with multi-comorbidities who more and more in the future will undergo such interventions...
July 18, 2017: Monaldi Archives for Chest Disease, Archivio Monaldi Per le Malattie del Torace
https://www.readbyqxmd.com/read/28955247/association-between-srd5a2-rs523349-and-rs9282858-polymorphisms-and-risk-of-benign-prostatic-hyperplasia-a-meta-analysis
#10
Xian-Tao Zeng, Xin-Jun Su, Sheng Li, Hong Weng, Tong-Zu Liu, Xing-Huan Wang
Objective: Previous studies have reported that rs523349 (V89L) and rs9282858 (A49T) polymorphisms in the gene 5α-reductase II (SRD5A2) are associated with the risk of benign prostatic hyperplasia (BPH), but different opinions have emerged. In view of distinct discrepancies among those findings, we performed this meta-analysis to ascertain a more accurate association between SRD5A2 rs523349 and rs9282858 polymorphisms and the risk of BPH. Methods: Studies investigating the association between SRD5A2 rs523349 and rs9282858 polymorphisms and susceptibility to BPH were searched from the databases of PubMed, Embase, Wanfang, and Chinese National Knowledge Infrastructure (CNKI)...
2017: Frontiers in Physiology
https://www.readbyqxmd.com/read/28948714/clinical-impact-of-tumor-location-on-the-colon-cancer-survival-and-recurrence-analyses-of-pooled-data-from-three-large-phase-iii-randomized-clinical-trials
#11
Toru Aoyama, Kosuke Kashiwabara, Koji Oba, Michitaka Honda, Sotaro Sadahiro, Chikuma Hamada, Hiromichi Maeda, Shuhei Mayanagi, Mitsuro Kanda, Junichi Sakamoto, Shigetoyo Saji, Takaki Yoshikawa
The aim of the present study was to determine whether or not the overall survival (OS) and disease-free survival (DFS) were affected by the tumor location in patients who underwent curative resection for colon cancer in a pooled analysis of three large phase III studies performed in Japan. In total, 4029 patients were included in the present study. Patients were classified as having right-side colon cancer (RC) if the primary tumor was located in the cecum, ascending colon, hepatic flexure or transverse colon, and left-side colon cancer (LCC) if the tumor site was within the splenic flexure, descending colon, sigmoid colon or recto sigmoid junction...
September 25, 2017: Cancer Medicine
https://www.readbyqxmd.com/read/28947734/targeted-gadofullerene-for-sensitive-magnetic-resonance-imaging-and-risk-stratification-of-breast-cancer
#12
Zheng Han, Xiaohui Wu, Sarah Roelle, Chuheng Chen, William P Schiemann, Zheng-Rong Lu
Molecular imaging of cancer biomarkers is critical for non-invasive accurate cancer detection and risk-stratification in precision healthcare. A peptide-targeted tri-gadolinium nitride metallofullerene, ZD2-Gd3N@C80, is synthesised for sensitive molecular magnetic resonance imaging of extradomain-B fibronectin in aggressive tumours. ZD2-Gd3N@C80 has superior r 1 and r 2 relaxivities of 223.8 and 344.7 mM(-1 )s(-1) (1.5 T), respectively. It generates prominent contrast enhancement in aggressive MDA-MB-231 triple negative breast cancer in mice at a low dose (1...
September 25, 2017: Nature Communications
https://www.readbyqxmd.com/read/28919101/3-4%C3%A2-6-implications-of-the-stratification-of-localised-gleason-7-prostate-cancer-by-number-and-percentage-of-positive-biopsy-cores-in-selecting-patients-for-active-surveillance
#13
J L Ruiz-Cerdá, L Lorenzo Soriano, D Ramos-Soler, L Marzullo-Zucchet, A Loras Monfort, F Boronat Tormo
OBJECTIVE: To determine whether the number and percentage of positive biopsy cores identify a Gleason 3+4 prostate cancer (PC) subgroup of similar biologic behaviour to Gleason 3+3. MATERIAL AND METHOD: An observational post-radical prostatectomy study was conducted of a cohort of 799 patients with localised low-risk (n=582, Gleason 6, PSA <10ng/ml and cT1c-2a) and favourable intermediate PC (n=217, Gleason 3+4, PSA ≤10 ng/ml and pT2abc). The Gleason 3+4 tumours were stratified by number (≤3 vs...
September 14, 2017: Actas Urologicas Españolas
https://www.readbyqxmd.com/read/28917674/prognostic-value-of-risk-factors-calcium%C3%A2-score-coronary-cta-myocardial%C3%A2-perfusion-imaging-and-invasive%C3%A2-coronary-angiography-in-kidney%C3%A2-transplantation-candidates
#14
Simon Winther, My Svensson, Hanne Skou Jørgensen, Laust Dupont Rasmussen, Niels Ramsing Holm, Lars Christian Gormsen, Kirsten Bouchelouche, Hans Erik Bøtker, Per Ivarsen, Morten Bøttcher
OBJECTIVES: This study sought to perform a prospective head-to-head comparison of the predictive value of clinical risk factors and a variety of cardiac imaging modalities including coronary artery calcium score (CACS), coronary computed tomography angiography (CTA), single-photon emission computed tomography (SPECT), and invasive coronary angiography (ICA) on major adverse cardiac events (MACE) and all-cause mortality in kidney transplantation candidates. BACKGROUND: Current guidelines recommend screening for coronary artery disease in kidney transplantation candidates...
September 9, 2017: JACC. Cardiovascular Imaging
https://www.readbyqxmd.com/read/28906373/predictive-value-of-insufficient-contrast-medium-filling-in-pulmonary-veins-in-patients-with-acute-pulmonary-embolism
#15
Hong Zhang, Yanhe Ma, Zhenchun Song, Jun Lv, Yapeng Yang
This study is to investigate the predictive value of insufficient contrast medium filling (ICMF) in patients with acute pulmonary embolism (PE).A total of 108 PE patients were enrolled and divided into group A and group B according to the presence of ICMF. PE index and ventricul araxial lengths were measured. Heart cavity volumes were examined and right ventricle (RV) to left ventricle (LV) diameter ratio (RV/LV(d)) and volume ratio (RV/LV(V)) and right atrium (RA) to left atrium (LA) volume ratio (RA/LA(V)) were calculated and compared...
September 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/28901655/clinically-insignificant-prostate-cancer-suitable-for-active-surveillance-according-to-prostate-cancer-research-international-active-surveillance-criteria-utility-of-pi-rads-v2
#16
Jae Hyun Yim, Chan Kyo Kim, Jae-Hun Kim
BACKGROUND: Active surveillance (AS) is an important treatment strategy for prostate cancer (PCa). Prostate Imaging-Reporting and Data System (PI-RADS) v2 has been addressed, but few studies have reported the value of PI-RADS v2 for assessing risk stratification in patients with PCa, especially on selecting potential candidates for AS. PURPOSE: To investigate the utility of PI-RADS v2 and apparent diffusion coefficient (ADC) in evaluating patients with insignificant PCa, who are suitable for AS...
September 13, 2017: Journal of Magnetic Resonance Imaging: JMRI
https://www.readbyqxmd.com/read/28901628/total-cosine-r-to-t-for-predicting-ventricular-arrhythmic-and-mortality-outcomes-a-systematic-review-and-meta-analysis
#17
Gary Tse, Mengqi Gong, Cheuk Wai Wong, Cynthia Chan, Stamatis Georgopoulos, Yat Sun Chan, Bryan P Yan, Guangping Li, Paula Whittaker, Ana Ciobanu, Sadeq Ali-Hasan-Al-Saegh, Sunny H Wong, William K K Wu, George Bazoukis, Konstantinos Lampropoulos, Wing Tak Wong, Lap Ah Tse, Adrian M Baranchuk, Konstantinos P Letsas, Tong Liu
BACKGROUND: The total cosine R-to-T (TCRT), a vectorcardiographic marker reflecting the spatial difference between the depolarization and repolarization wavefronts, has been used to predict ventricular tachycardia/fibrillation (VT/VF) and sudden cardiac death (SCD) in different clinical settings. However, its prognostic value has been controversial. OBJECTIVE: This systematic review and meta-analysis evaluated the significance of TRCT in predicting arrhythmic and/or mortality endpoints...
September 12, 2017: Annals of Noninvasive Electrocardiology
https://www.readbyqxmd.com/read/28893325/the-most-commonly-used-disease-severity-scores-are-inappropriate-for-risk-stratification-of-older-emergency-department-sepsis-patients-an-observational-multi-centre-study
#18
Bas de Groot, Frank Stolwijk, Mats Warmerdam, Jacinta A Lucke, Gurpreet K Singh, Mo Abbas, Simon P Mooijaart, Annemieke Ansems, Laura Esteve Cuevas, Douwe Rijpsma
BACKGROUND: Sepsis recognition in older emergency department (ED) patients is difficult due to atypical symptom presentation. We therefore investigated whether the prognostic and discriminative performance of the five most commonly used disease severity scores were appropriate for risk stratification of older ED sepsis patients (≥70 years) compared to a younger control group (<70 years). METHODS: This was an observational multi-centre study using an existing database in which ED patients who were hospitalized with a suspected infection were prospectively included...
September 11, 2017: Scandinavian Journal of Trauma, Resuscitation and Emergency Medicine
https://www.readbyqxmd.com/read/28883284/pediatric-acute-myeloid-leukemia-with-genetic-alterations
#19
Akira Shimada
Annually, it is estimated that approximately 150-200 children aged 0-16 years are diagnosed with acute myeloid leukemia (AML). In Japan, clinical studies with ANLL91, AML99, CCLSG-AML9805, and JPLSG-AML05 protocols were performed historically, and the risk stratification with a combination of chemotherapy and hematopoietic stem cell transplantation resulted in the improvement of clinical outcomes. Regarding the onset of pediatric AML at the molecular level, mutations in FLT3-ITD or KIT (Class I mutation) showed a poor prognosis, but the ratio of mutations in Class III-V genes was smaller than that in adult AML...
2017: [Rinshō Ketsueki] the Japanese Journal of Clinical Hematology
https://www.readbyqxmd.com/read/28872191/cutaneous-t-cell-lymphoma-2017-update-on-diagnosis-risk-stratification-and-management
#20
REVIEW
Ryan A Wilcox
DISEASE OVERVIEW: Cutaneous T-cell lymphomas are a heterogenous group of T-cell lymphoproliferative disorders involving the skin, the majority of which may be classified as Mycosis Fungoides (MF) or Sézary Syndrome (SS). DIAGNOSIS: The diagnosis of MF or SS requires the integration of clinical and histopathologic data. RISK-ADAPTED THERAPY: TNMB (tumor, node, metastasis, blood) staging remains the most important prognostic factor in MF/SS and forms the basis for a "risk-adapted," multi-disciplinary approach to treatment...
October 2017: American Journal of Hematology
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