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https://www.readbyqxmd.com/read/27897042/state-of-the-art-pulmonary-ct-angiography-for-acute-pulmonary-embolism
#1
Moritz H Albrecht, Matthew W Bickford, John W Nance, Longjiang Zhang, Carlo N De Cecco, Julian L Wichmann, Thomas J Vogl, U Joseph Schoepf
OBJECTIVE: Pulmonary CT angiography (CTA) is the imaging modality of choice in suspected acute pulmonary embolism (PE). Current pulmonary CTA techniques involve ever lower doses of contrast medium and radiation along with advanced postprocessing applications to enhance image quality, diagnostic accuracy, and provide added value in patient management. The objective of this article is to summarize these current developments and discuss the appropriate use of state-of-the-art pulmonary CTA...
November 29, 2016: AJR. American Journal of Roentgenology
https://www.readbyqxmd.com/read/27854313/association-between-the-angiotensin-converting-enzyme-ace-genetic-polymorphism-and-diabetic-retinopathy-a-meta-analysis-comprising-10-168-subjects
#2
Shasha Luo, Chao Shi, Furu Wang, Zhifeng Wu
Aims-to address the inconclusive findings of the association of angiotensin-converting enzyme (ACE) insertion/deletion (I/D) polymorphism on risk of diabetic retinopathy (DR), a meta-analysis was conducted. Methods-we conducted a meta-analysis on 4252 DR cases and 5916 controls from 40 published studies by searching electronic databases and reference lists of relevant articles. A random-effects or fixed-effects model was used to estimate the overall and stratification effect sizes on ACE I/D polymorphism on the risk of DR...
November 15, 2016: International Journal of Environmental Research and Public Health
https://www.readbyqxmd.com/read/27845355/prevalence-and-associated-factors-of-pain-in-the-swiss-spinal-cord-injury-population
#3
R Müller, M W G Brinkhof, U Arnet, T Hinrichs, G Landmann, X Jordan, M Béchir
STUDY DESIGN: Population-based, cross-sectional. OBJECTIVES: To determine pain prevalence and identify factors associated with chronic pain in individuals with spinal cord injury (SCI) living in Switzerland. SETTING: Swiss SCI Cohort Study (SwiSCI). METHODS: Pain characteristics were assessed using an adapted version of the International SCI Pain Basic Data Set, adding one item of the SCI Secondary Conditions Scale to address chronic pain...
November 15, 2016: Spinal Cord
https://www.readbyqxmd.com/read/27844329/effect-of-follicle-stimulating-hormone-receptor-gene-polymorphisms-in-cervical-cancer-risk
#4
Sabrina Zidi, Mouna Stayoussef, Bano L Alsaleh, Ezzedine Gazouani, Amel Mezlini, Bashayer H Ebrahim, Besma Yacoubi-Loueslati, Wassim Y Almawi
For the first time in the word, we investigated the association between five FSHR polymorphisms with the risk of cervical cancer among Tunisians. Study subjects comprised 112 Cervical Cancer (CC) patients and 164 control women. Genotyping of FSHR rs6166, rs1007541, rs11692782, rs2055571 and rs1394205 variants was done by realtime PCR, with defined clusters. The allelic distributions of the tested FSHR SNPs were comparable between CC patients and control women. In contrast, the heterozygous genotype of rs1007541 was associated with 1...
November 14, 2016: Pathology Oncology Research: POR
https://www.readbyqxmd.com/read/27831955/ce-preventing-contrast-induced-acute-kidney-injury
#5
Yvonne Gallegos, Asma Ali Taha, Dana N Rutledge
: Diagnostic radiographic imaging scans using intravascular iodinated contrast media can lead to various complications. The most salient of these is contrast-induced acute kidney injury (CI-AKI) or contrast-induced nephropathy, a potentially costly and serious patient safety concern. Prevention strategies are the cornerstone of evidence-based clinical management for patients receiving contrast agents. These include preprocedure screening, stratification of patients based on risk factors, and protective interventions, the most important of which is hydration both before and after the radiographic imaging scan...
December 2016: American Journal of Nursing
https://www.readbyqxmd.com/read/27815307/state-of-the-art-blood-biomarkers-for-risk-stratification-in-patients-with-stable-ischemic-heart-disease
#6
REVIEW
Torbjørn Omland, Harvey D White
BACKGROUND: Multiple circulating biomarkers have been associated with the incidence of cardiovascular events and proposed as potential tools for risk stratification in stable ischemic heart disease (IHD), yet current guidelines do not make any firm recommendations concerning the use of biomarkers for risk stratification in this setting. This state-of-the-art review provides an overview of biomarkers for risk stratification in stable IHD. CONTENT: Circulating biomarkers associated with the risk of cardiovascular events in patients with stable IHD reflect different pathophysiological processes, including myocardial injury, myocardial stress and remodeling, metabolic status, vascular inflammation, and oxidative stress...
November 4, 2016: Clinical Chemistry
https://www.readbyqxmd.com/read/27812894/breast-cancer-risk-assessment-a-non-invasive-multiparametric-approach-to-stratify-patients-by-mmp-9-serum-activity-and-rhoa-expression-patterns-in-circulating-leucocytes
#7
Olga Golubnitschaja, Kristina Yeghiazaryan, Jella-Andrea Abraham, Hans H Schild, Vincenzo Costigliola, Manuel Debald, Walther Kuhn
Breast cancer is a multifactorial disease classified by several sub-types which differ from each other by risk factors, specific molecular promoters and severity of outcomes. Tumour aggressiveness and metastatic disease are the key determinants of breast cancer outcomes. Tumour cell ability to degrade the extracellular matrix and to be motile is the hallmark of invasion and essential step in a development of breast cancer metastatic disease. Therefore, a coordinated action between cell motility and ability to degrade the extracellular matrix is currently under extensive investigation focused on molecular targets for both diagnostic and therapeutic purposes...
November 3, 2016: Amino Acids
https://www.readbyqxmd.com/read/27803053/polymorphisms-in-microrna-binding-sites-of-mucin-genes-as-predictors-of-clinical-outcome-in-colorectal-cancer-patients
#8
Veronika Vymetalkova, Barbara Pardini, Fabio Rosa, Katerina Jiraskova, Cornelia Di Gaetano, Petra Bendova, Miloslav Levy, Veronika Veskrnova, Tomas Buchler, Ludmila Vodickova, Alessio Naccarati, Pavel Vodicka
Polymorphisms in microRNA (miRNA) binding sites may affect miRNA/target gene interaction, resulting in differential mRNA/protein expression and susceptibility to common diseases. Mucins have been identified as markers of adverse prognosis. We hypothesized that genetic variations in miRNA binding sites located in mucin genes may modulate signaling response and the maintenance of genomic stability ultimately affecting cancer susceptibility, efficacy of chemotherapy and survival.In the present study, we analyzed the association of single nucleotide polymorphisms in predicted miRNA target sites (miRSNPs) of mucin genes with colorectal cancer (CRC) risk and clinical outcome...
November 1, 2016: Carcinogenesis
https://www.readbyqxmd.com/read/27801961/heterogeneous-impact-of-drinking-according-to-treatment-method-on-survival-in-head-and-neck-cancer-a-prospective-study
#9
Michi Sawabe, Hidemi Ito, Isao Oze, Satoyo Hosono, Daisuke Kawakita, Hideo Tanaka, Yasuhisa Hasegawa, Shingo Murakami, Keitaro Matsuo
Alcohol consumption is an established risk factor, and also a potential prognostic factor, for squamous cell carcinoma of the head and neck (HNSCC). However, little is known about whether the prognostic impact of alcohol consumption differs by treatment modality. Here, we evaluated the association between alcohol drinking and survival by treatment method to the primary site in 427 patients with HNSCC treated between 2005-2013 at Aichi Cancer Center Central Hospital. The impact of alcohol on prognosis was measured by multivariable Cox regression adjusted for established prognostic factors...
November 1, 2016: Cancer Science
https://www.readbyqxmd.com/read/27787873/neutrophil-to-lymphocyte-ratio-as-a-bladder-cancer-biomarker-assessing-prognostic-and-predictive-value-in-swog-8710
#10
Eric Ojerholm, Andrew Smith, Wei-Ting Hwang, Brian C Baumann, Kai N Tucker, Seth P Lerner, Ronac Mamtani, Ben Boursi, John P Christodouleas
BACKGROUND: Risk stratification is a major challenge in bladder cancer (BC), and a biomarker is needed. Multiple studies have reported the neutrophil-to-lymphocyte ratio (NLR) as a promising candidate; however, these analyses have methodological limitations. Therefore, the authors performed a category B biomarker study to test whether NLR is prognostic for overall survival (OS) after curative treatment or is predictive for the survival benefit from neoadjuvant chemotherapy (NAC). METHODS: This study is an unplanned secondary analysis of SWOG 8710, a randomized phase 3 trial that assessed cystectomy with or without NAC in 317 patients with muscle-invasive BC...
October 27, 2016: Cancer
https://www.readbyqxmd.com/read/27785420/why-are-upper-tract-urothelial-carcinoma-two-different-diseases
#11
REVIEW
Tibor Szarvas, Orsolya Módos, András Horváth, Péter Nyirády
In the last few years growing evidence highlighted the differences between upper tract urothelial carcinoma (UTUC) and urothelial bladder carcinoma (UBC) which cannot be explained solely by their different anatomical location. The aim of this review was to summarize current progress in UTUC research and to underline the differences and similarities between UTUC and UBC by focusing on epidemiology, etiology, staging and risk factors as well as on surgical and medical management. UBC and UTUC sharing common risk factors such as smoking and aromatic amines, while aristolochic acid exposure or familiar Lynch syndrome are rather specific for UTUC...
October 2016: Translational Andrology and Urology
https://www.readbyqxmd.com/read/27770118/diagnostic-performance-of-contrast-enhanced-ultrasound-in-the-evaluation-of-renal-masses-in-patients-with-renal-impairment
#12
C Yong, Y M Teo, K Jeevesh
OBJECTIVE: To evaluate the performance of contrastenhanced ultrasound (CEUS) in the risk stratification of indeterminate renal lesions picked up incidentally on abdominal imaging, in patients with renal impairment. METHODS: A retrospective study was performed of nonconsecutive patients who underwent CEUS at our tertiary care centre for indeterminate renal lesions between March 2010 and September 2014. A total of 63 patients with 74 nodules were assessed with CEUS and stratified into either benign (Bosniak I, II, IIF) or suspicious for malignancy (Bosniak III, IV or hypervascular solid lesions)...
August 2016: Medical Journal of Malaysia
https://www.readbyqxmd.com/read/27760781/biomarkers-for-clinical-decision-making-in-the-management-of-pulmonary-embolism
#13
Evangelos Giannitsis, Hugo A Katus
BACKGROUND: Pulmonary embolism (PE) is associated with high all-cause and PE-related mortality and requires individualized management. After confirmation of PE, a refined risk stratification is particularly warranted among normotensive patients. Previous prognostic models favored combinations of echocardiography or computed tomography suggestive of right ventricular (RV) dysfunction together with biomarkers of RV dysfunction (natriuretic peptides) or myocardial injury (cardiac troponins) to identify candidates for thrombolysis or embolectomy...
October 19, 2016: Clinical Chemistry
https://www.readbyqxmd.com/read/27759788/understanding-the-international-consensus-for-acute-pancreatitis-classification-of-atlanta-2012
#14
Gleim Dias de Souza, Luciana Rodrigues Queiroz Souza, Ronaldo Máfia Cuenca, Bárbara Stephane de Medeiros Jerônimo, Guilherme Medeiros de Souza, Vinícius Martins Vilela
Introduction: Contrast computed tomography and magnetic resonance imaging are widely used due to its image quality and ability to study pancreatic and peripancreatic morphology. The understanding of the various subtypes of the disease and identification of possible complications requires a familiarity with the terminology, which allows effective communication between the different members of the multidisciplinary team. Aim: Demonstrate the terminology and parameters to identify the different classifications and findings of the disease based on the international consensus for acute pancreatitis ( Atlanta Classification 2012)...
July 2016: Arquivos Brasileiros de Cirurgia Digestiva: ABCD, Brazilian Archives of Digestive Surgery
https://www.readbyqxmd.com/read/27752629/pulmonary-embolism-the-diagnosis-risk-stratification-treatment-and-disposition-of-emergency-department-patients
#15
Daniel Corrigan, Christiana Prucnal, Christopher Kabrhel
The diagnosis or exclusion of pulmonary embolism (PE) remains challenging for emergency physicians. Symptoms can be vague or non-existent, and the clinical presentation shares features with many other common diagnoses. Diagnostic testing is complicated, as biomarkers, like the D-dimer, are frequently false positive, and imaging, like computed tomography pulmonary angiography, carries risks of radiation and contrast dye exposure. It is therefore incumbent on emergency physicians to be both vigilant and thoughtful about this diagnosis...
September 2016: Clinical and Experimental Emergency Medicine
https://www.readbyqxmd.com/read/27730170/patterns-predictors-and-outcomes-of-asthma-control-and-exacerbations-during-pregnancy-a-prospective-cohort-study
#16
Luke E Grzeskowiak, Brian Smith, Anil Roy, Gustaaf A Dekker, Vicki L Clifton
There exists a paucity of data for socially disadvantaged populations describing patterns and predictors of asthma control status and exacerbations during pregnancy, and their relationship to adverse perinatal outcomes. Asthmatic women (n=189) were followed prospectively during pregnancy, with visits at 12, 20, 28 and 36 weeks gestation. Data on loss of control, recurrent uncontrolled asthma and moderate/severe exacerbations were collected at each visit and their relationship to perinatal outcomes examined following stratification for fetal sex...
January 2016: ERJ Open Research
https://www.readbyqxmd.com/read/27720540/best-clinical-practice-current-controversies-in-pulmonary-embolism-imaging-and-treatment-of-subsegmental-thromboembolic-disease
#17
Brit Long, Alex Koyfman
BACKGROUND: Pulmonary embolism (PE) affects >600,000 patients per year in the United States. Evaluation includes clinical decision rules, laboratory tests, and several imaging modalities. The diagnosis of PE has risen in recent years, particularly subsegmental PE (SSPE). Controversy exists concerning the diagnosis and treatment of these lesions. OBJECTIVE: We sought to provide emergency physicians with a review of the controversies surrounding PE testing and the diagnosis and treatment of SSPE...
October 6, 2016: Journal of Emergency Medicine
https://www.readbyqxmd.com/read/27686946/temozolomide-chemotherapy-versus-radiotherapy-in-high-risk-low-grade-glioma-eortc-22033-26033-a-randomised-open-label-phase-3-intergroup-study
#18
Brigitta G Baumert, Monika E Hegi, Martin J van den Bent, Andreas von Deimling, Thierry Gorlia, Khê Hoang-Xuan, Alba A Brandes, Guy Kantor, Martin J B Taphoorn, Mohamed Ben Hassel, Christian Hartmann, Gail Ryan, David Capper, Johan M Kros, Sebastian Kurscheid, Wolfgang Wick, Roelien Enting, Michele Reni, Brian Thiessen, Frederic Dhermain, Jacoline E Bromberg, Loic Feuvret, Jaap C Reijneveld, Olivier Chinot, Johanna M M Gijtenbeek, John P Rossiter, Nicolas Dif, Carmen Balana, Jose Bravo-Marques, Paul M Clement, Christine Marosi, Tzahala Tzuk-Shina, Robert A Nordal, Jeremy Rees, Denis Lacombe, Warren P Mason, Roger Stupp
BACKGROUND: Outcome of low-grade glioma (WHO grade II) is highly variable, reflecting molecular heterogeneity of the disease. We compared two different, single-modality treatment strategies of standard radiotherapy versus primary temozolomide chemotherapy in patients with low-grade glioma, and assessed progression-free survival outcomes and identified predictive molecular factors. METHODS: For this randomised, open-label, phase 3 intergroup study (EORTC 22033-26033), undertaken in 78 clinical centres in 19 countries, we included patients aged 18 years or older who had a low-grade (WHO grade II) glioma (astrocytoma, oligoastrocytoma, or oligodendroglioma) with at least one high-risk feature (aged >40 years, progressive disease, tumour size >5 cm, tumour crossing the midline, or neurological symptoms), and without known HIV infection, chronic hepatitis B or C virus infection, or any condition that could interfere with oral drug administration...
November 2016: Lancet Oncology
https://www.readbyqxmd.com/read/27675655/risk-stratification-incorporating-complementary-contrast-computed-tomography-texture-features-for-prognosis-in-primary-gastroesophageal-junction-adenocarcinoma
#19
Q Wang, S Zhou, L E Court, E J Koay, L Zhang, W Zhang, S H Lin, C Tang, J W Welsh, W L Hofstetter, J Y Chang
No abstract text is available yet for this article.
October 1, 2016: International Journal of Radiation Oncology, Biology, Physics
https://www.readbyqxmd.com/read/27650702/cutaneous-b-cell-lymphomas-2016-update-on-diagnosis-risk-stratification-and-management
#20
Ryan A Wilcox
DISEASE OVERVIEW: Approximately one-fourth of cutaneous lymphomas are B-cell derived and are generally classified into three distinct subgroups: primary cutaneous follicle center lymphoma (PCFCL), primary cutaneous marginal zone lymphoma (PCMZL), and primary cutaneous diffuse large B-cell lymphoma, leg type (PCDLBCL, LT). DIAGNOSIS: Diagnosis and disease classification is based on histologic review and immunohistochemical staining of an appropriate skin biopsy. Pathologic review and an appropriate staging evaluation are necessary to distinguish primary cutaneous B-cell lymphomas from systemic B-cell lymphomas with secondary skin involvement...
October 2016: American Journal of Hematology
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