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https://www.readbyqxmd.com/read/28721448/-pi-rads-2-0-for-prostate-mri
#1
T Franiel, M Röthke
The PI-RADS 2.0 classification was established by an international collaboration of the European Society of Urogenital Radiology (ESUR), the American College of Radiology (ACR), and AdMetech Foundation to globally standardize the acquisition and interpretation of multiparametric prostate magnetic resonance imaging (MRI). The PI-RADS 2.0 aims to improve the detection, localization, staging and risk stratification of patients with suspected or histologically confirmed prostate cancer. Suspicious areas on T2-weighted (T2w) MRI, diffusion-weighted MRI (DWI) and dynamic contrast-enhanced MRI (DCE-MRI) were assessed for the presence of a clinically significant prostate cancer with scale from 1 to 5 with 5 being most likely to represent clinically significant prostate cancer...
July 18, 2017: Der Radiologe
https://www.readbyqxmd.com/read/28709889/dynamic-contrast-enhanced-mri-improves-classification-of-prostate-lesions-a-study-of-pathologic-outcomes-on-targeted-prostate-biopsy
#2
Sasha C Druskin, Ryan Ward, Andrei S Purysko, Allen Young, Jeffrey J Tosoian, Kamyar Ghabili, Darian Andreas, Eric Klein, Ashley E Ross, Katarzyna J Macura
PURPOSE: PIRADSv2 stipulates that dynamic-contrast-enhanced-imaging (DCE) be used to classify diffusion-weighted-imaging (DWI) score 3 (DWI3) peripheral-zone (PZ) lesions as PIRADS score 3 (PIRADS3; DCE-) or PIRADS4 (DCE+). However, it is unknown if DCE separates lesions into clinically-meaningful pathologic groups. We examined whether use of DCE improves detection of clinically-significant cancer. MATERIALS & METHODS: We identified patients without a prior diagnosis of prostate cancer undergoing multiparametric-MRI-transrectal-ultrasound fusion targeted-biopsy of PZ DWI3 or DWI4 lesions...
July 11, 2017: Journal of Urology
https://www.readbyqxmd.com/read/28708022/is-intravenous-administration-of-iodixanol-associated-with-increased-risk-of-acute-kidney-injury-dialysis-or-mortality-a-propensity-score-adjusted-study
#3
Jennifer S McDonald, Robert J McDonald, Eric E Williamson, David F Kallmes
Purpose To compare the rates of acute kidney injury (AKI), emergent dialysis, and short-term mortality between patients who underwent intravenous administration of the iso-osmolar contrast material (IOCM) iodixanol 320 and patients who underwent a noncontrast computed tomography (CT) examination. Materials and Methods Study design and implementation were overseen by an institutional review board and conformed to HIPAA guidelines on patient data integrity. All patients who underwent an iodixanol-enhanced (IOCM group) or a noncontrast (noncontrast group) CT examination from January 2003 to December 2014 were identified...
July 13, 2017: Radiology
https://www.readbyqxmd.com/read/28701328/inpatient-mortality-risk-scores-and-postdischarge-events-in-hospitalized-heart-failure-patients-a-community-based-study
#4
Sithu Win, Imad Hussain, Virginia B Hebl, Shannon M Dunlay, Margaret M Redfield
BACKGROUND: The Acute Decompensated Heart Failure National Registry (ADHERE) and Get With The Guidelines (GWTG) registries have developed simple heart failure (HF) in-hospital mortality risk scores. We hypothesized that HF scores predictive of in-hospital mortality would perform as well for early postdischarge mortality risk stratification. METHODS AND RESULTS: In this single-center, community-based, retrospective study of all consecutive primary HF hospitalizations (6203 hospitalizations in 3745 patients) from 2000 to 2013, the ADHERE and GWTG risk scores were calculated from admission data...
July 2017: Circulation. Heart Failure
https://www.readbyqxmd.com/read/28695611/prediction-of-type-1-diabetes-using-a-genetic-risk-model-in-the-diabetes-autoimmunity-study-in-the-young
#5
Brigitte I Frohnert, Michael Laimighofer, Jan Krumsiek, Fabian J Theis, Christiane Winkler, Jill M Norris, Anette-Gabriele Ziegler, Marian J Rewers, Andrea K Steck
BACKGROUND: Genetic predisposition for type 1 diabetes (T1D) is largely determined by human leukocyte antigen (HLA) genes; however, over 50 other genetic regions confer susceptibility. We evaluated a previously reported 10-factor weighted model derived from the Type 1 Diabetes Genetics Consortium to predict the development of diabetes in the Diabetes Autoimmunity Study in the Young (DAISY) prospective cohort. Performance of the model, derived from individuals with first-degree relatives (FDR) with T1D, was evaluated in DAISY general population (GP) participants as well as FDR subjects...
July 11, 2017: Pediatric Diabetes
https://www.readbyqxmd.com/read/28692375/non-invasive-imaging-in-cardiology-for-the-generalist
#6
Mark J Davies, James D Newton
In contrast to invasive techniques, the goal of non-invasive cardiac imaging is to identify or exclude heart disease in response to a patient's clinical history of cardiac localizing symptoms. Imaging also aims to establish the risk of an individual developing future heart disease with a view to preventing major cardiovascular events such as myocardial infarction. As well as a role in risk stratification, non-invasive cardiac imaging also helps with decision making for future medical and procedural interventions...
July 2, 2017: British Journal of Hospital Medicine
https://www.readbyqxmd.com/read/28689281/optimal-fdg-pet-ct-volumetric-parameters-for-risk-stratification-in-patients-with-locally-advanced-non-small-cell-lung-cancer-results-from-the-acrin-6668-rtog-0235-trial
#7
Ali Salavati, Fenghai Duan, Bradley S Snyder, Bo Wei, Sina Houshmand, Benjapa Khiewvan, Adam Opanowski, Charles B Simone, Barry A Siegel, Mitchell Machtay, Abass Alavi
PURPOSE: In recent years, multiple studies have demonstrated the value of volumetric FDG-PET/CT parameters as independent prognostic factors in patients with non-small cell lung cancer (NSCLC). We aimed to determine the optimal cut-off points of pretreatment volumetric FDG-PET/CT parameters in predicting overall survival (OS) in patients with locally advanced NSCLC and to recommend imaging biomarkers appropriate for routine clinical applications. METHODS: Patients with inoperable stage IIB/III NSCLC enrolled in ACRIN 6668/RTOG 0235 were included...
July 8, 2017: European Journal of Nuclear Medicine and Molecular Imaging
https://www.readbyqxmd.com/read/28687913/risk-stratification-of-gallbladder-polyps-larger-than-10-mm-using-high-resolution-ultrasonography-and-texture-analysis
#8
Tae Won Choi, Jung Hoon Kim, Sang Joon Park, Su Joa Ahn, Ijin Joo, Joon Koo Han
OBJECTIVES: To assess important features for risk stratification of gallbladder (GB) polyps >10 mm using high-resolution ultrasonography (HRUS) and texture analysis. METHODS: We included 136 patients with GB polyps (>10 mm) who underwent both HRUS and cholecystectomy (non-neoplastic, n = 58; adenomatous, n = 32; and carcinoma, n = 46). Two radiologists retrospectively assessed HRUS findings and texture analysis. Multivariate analysis was performed to identify significant predictors for neoplastic polyps and carcinomas...
July 7, 2017: European Radiology
https://www.readbyqxmd.com/read/28685522/next-generation-post-evar-follow-up-regime
#9
Rita Soares Ferreira, Frederico Bastos Gonçalves
Durability of endovascular aneurysm repair is critical, since a significant proportion of patients suffer from procedure-related complications and secondary interventions after repair of abdominal aortic aneurysms. Therefore, regular follow up including imaging is recommended. The rationale behind current surveillance programs is to allow early detection and elective treatment of complications. However, current recommendations are laborious and resource consuming, may be deleterious to many patients and are largely inefficient...
July 7, 2017: Journal of Cardiovascular Surgery
https://www.readbyqxmd.com/read/28669514/identification-of-urine-metabolites-associated-with-5-year-changes-in-biomarkers-of-glucose-homoeostasis
#10
N Friedrich, T Skaaby, M Pietzner, K Budde, B H Thuesen, M Nauck, A Linneberg
AIM: Metabolomics provides information on pathogenetic mechanisms and targets for interventions, and may improve risk stratification. During the last decade, metabolomics studies were used to gain deeper insight into the pathogenesis of diabetes mellitus. However, longitudinal metabolomics studies of possible subclinical states of disturbed glucose metabolism are limited. Therefore, the aim of this study was to analyze the associations between baseline urinary metabolites and 5-year changes in continuous markers of glucose homoeostasis, including fasting glucose, HbA1c and homoeostasis model assessment of insulin resistance (HOMA-IR) index values...
June 29, 2017: Diabetes & Metabolism
https://www.readbyqxmd.com/read/28664940/clinical-implications-of-cytogenetic-heterogeneity-in-multiple-myeloma-patients-with-tp53-deletion
#11
Suyang Hao, Pei Lin, L Jeffrey Medeiros, Lianghua Fang, Adrian A Carballo-Zarate, Sergej N Konoplev, Rachel L Sargent, Donna M Weber, Sheeba K Thomas, Elisabet E Manasanch, Robert Z Orlowski, Xinyan Lu
TP53 deletion (ΔTP53) in myeloma is known to be a high-risk finding associated with poorer prognosis. The prognostic impact of underlying cytogenetic heterogeneity in patients with myeloma associated with ΔTP53 is unknown. We studied 90 patients with myeloma associated with ΔTP53 identified by interphase fluorescence in situ hybridization and assessed the impact of karyotype and coexisting alterations of IGH, RB1, and CKS1B. There were 54 men and 36 women with a median age of 59 years (range 38-84); 14 patients had a normal karyotype (NK/ΔTP53), 73 had a complex karyotype (CK/ΔTP53), and 3 had a non-complex abnormal karyotype...
June 30, 2017: Modern Pathology: An Official Journal of the United States and Canadian Academy of Pathology, Inc
https://www.readbyqxmd.com/read/28662299/thrombotic-risk-stratification-by-platelet-count-in-patients-with-antiphospholipid-antibodies-a-longitudinal-study
#12
Ryo Hisada, Masaru Kato, Eri Sugawara, Yuichiro Fujieda, Kenji Oku, Toshiyuki Bohgaki, Olga Amengual, Shinsuke Yasuda, Tatsuya Atsumi
BACKGROUND: Thrombocytopenia is a non-criteria clinical manifestation of antiphospholipid syndrome (APS). However, it remains to be elucidated whether thrombocytopenia increases thrombotic risk in antiphospholipid antibody (aPL) carriers. OBJECTIVES: To investigate the impact of platelet count in terms of predicting thrombotic events in aPL carriers and to stratify the thrombotic risk by combining platelet count and antiphospholipid score (aPL-S), which represents a quantification of aPL varieties and titres PATIENTS/METHODS: A single centre retrospective, longitudinal study comprising 953 consecutive patients who were suspected to have autoimmune disease between January 2002 and December 2006...
June 29, 2017: Journal of Thrombosis and Haemostasis: JTH
https://www.readbyqxmd.com/read/28648478/imaging-vulnerable-plaques-by-targeting-inflammation-in-atherosclerosis-using-fluorescent-labeled-dual-ligand-microparticles-of-iron-oxide-and-magnetic-resonance-imaging
#13
Joyce M S Chan, Claudia Monaco, Marzena Wylezinska-Arridge, Jordi L Tremoleda, Jennifer E Cole, Michael Goddard, Maggie S H Cheung, Kishore K Bhakoo, Richard G J Gibbs
OBJECTIVE: Identification of patients with high-risk asymptomatic carotid plaques remains an elusive but essential step in stroke prevention. Inflammation is a key process in plaque destabilization and a prelude to clinical sequelae. There are currently no clinical imaging tools to assess the inflammatory activity within plaques. This study characterized inflammation in atherosclerosis using dual-targeted microparticles of iron oxide (DT-MPIO) as a magnetic resonance imaging (MRI) probe...
June 22, 2017: Journal of Vascular Surgery
https://www.readbyqxmd.com/read/28646593/mri-assisted-dual-motion-correction-for-myocardial-perfusion-defect-detection-in-pet-imaging
#14
Xinhui Wang, Arman Rahmim, Jing Tang
PURPOSE: Myocardial perfusion (MP) PET imaging is a powerful tool in risk assess-assessment and stratification of patients with coronary artery disease. Involuntary organmotion degrades cardiac PET image resolution while respiratory and/or cardiac gating to freeze the motion leads to noisier reconstructed images due to reduced counts in the gated frames. In this work, we propose an MRI assisted dual motion correction method to compensate for respiratory and cardiac motion in MP PET data and study the impact of dual motion correction on MP defect detection using systematically designed experiments...
June 24, 2017: Medical Physics
https://www.readbyqxmd.com/read/28645632/adjuvant-chemotherapy-guided-by-molecular-profiling-and-improved-outcomes-in-early-stage-non-small-cell-lung-cancer
#15
Gavitt A Woodard, Sue X Wang, Johannes R Kratz, Clara T Zoon-Besselink, Chun-Yuan Chiang, Matthew A Gubens, Thierry M Jahan, Collin M Blakely, Kirk D Jones, Michael J Mann, David M Jablons
INTRODUCTION: Many early stage non-small-cell lung cancer (NSCLC) patients who are not considered candidates for adjuvant treatment according to current guidelines do harbor occult metastasis, and have disease recurrence despite complete resection. Although National Comprehensive Cancer Network (NCCN) guidelines suggest clinicopathologic characteristics to identify high-risk patients for adjuvant intervention, molecular profiling more accurately predicts 5-year survival. Early evidence of clinical benefit from application of this molecular-based management strategy, however, has not been reported...
May 31, 2017: Clinical Lung Cancer
https://www.readbyqxmd.com/read/28642994/cardiovascular-magnetic-resonance-imaging-to-assess-myocardial-fibrosis-in-valvular-heart-disease
#16
Tomaz Podlesnikar, Victoria Delgado, Jeroen J Bax
The left ventricular (LV) remodeling process associated with significant valvular heart disease (VHD) is characterized by an increase of myocardial interstitial space with deposition of collagen and loss of myofibers. These changes occur before LV systolic function deteriorates or the patient develops symptoms. Cardiovascular magnetic resonance (CMR) permits assessment of reactive fibrosis, with the use of T1 mapping techniques, and replacement fibrosis, with the use of late gadolinium contrast enhancement...
June 22, 2017: International Journal of Cardiovascular Imaging
https://www.readbyqxmd.com/read/28642288/ferumoxytol-enhanced-magnetic-resonance-imaging-assessing-inflammation-after-myocardial-infarction
#17
Colin G Stirrat, Shirjel R Alam, Thomas J MacGillivray, Calum D Gray, Marc R Dweck, Jennifer Raftis, William Sa Jenkins, William A Wallace, Renzo Pessotto, Kelvin Hh Lim, Saeed Mirsadraee, Peter A Henriksen, Scott Ik Semple, David E Newby
OBJECTIVES: Macrophages play a central role in the cellular inflammatory response to myocardial infarction (MI) and predict subsequent clinical outcomes. We aimed to assess temporal changes in cellular inflammation and tissue oedema in patients with acute MI using ultrasmallsuperparamagnetic particles of iron oxide (USPIO)-enhanced MRI. METHODS: Thirty-one patients were recruited following acute MI and followed up for 3 months with repeated T2 and USPIO-enhanced T2*-mapping MRI...
June 22, 2017: Heart: Official Journal of the British Cardiac Society
https://www.readbyqxmd.com/read/28627979/association-between-transforming-growth-factor-beta-1-gene-single-nucleotide-polymorphisms-and-knee-osteoarthritis-susceptibility-in-a-chinese-han-population
#18
Ning Lu, Jianwei Lu, Chenhe Zhou, FuHua Zhong
Objective To investigate associations between single polymorphisms (SNPs) rs1800469 and rs1982073 in the transforming growth factor-β1 gene ( TGF-β1) and knee osteoarthritis (OA) susceptibility in a Chinese Han population. Methods TGF-β1 rs1800469 and rs1982073 were genotyped in patients with knee OA and age- and sex-matched OA-free controls from a Chinese Han population. The association was further analyzed according to gender and age. Results A total of 765 patients with knee OA and 780 controls were included...
January 1, 2017: Journal of International Medical Research
https://www.readbyqxmd.com/read/28614597/esc-sudden-death-risk-model-in-hypertrophic-cardiomyopathy-incremental-value-of-quantitative-contrast-enhanced-cmr-in-intermediate-risk-patients
#19
Rocio Hinojar, José Luis Zamorano, Ariana Gonzalez Gómez, Maria Plaza Martin, Amparo Esteban, Luis Miguel Rincón, Juan Carlos Portugal, José Julio Jimenez Nácher, Covadonga Fernández-Golfín
BACKGROUND: Hypertrophic cardiomyopathy (HCM) remains the most common cause of sudden cardiac death (SCD) in the young; however, current strategies do not identify all HCM patients at risk. A novel validated algorithm was proposed by the last European Society of Cardiology guidelines to guide implantable cardioverter-defibrillator (ICD) therapy. Recently, extensive myocardial fibrosis was independently associated with increased risk of SCD events. This study aimed to establish the relation between myocardial fibrosis (late gadolinium enhancement [LGE] extension) and the novel SCD risk-prediction model in a real population of HCM to evaluate its potential additional value in the different risk groups...
June 14, 2017: Clinical Cardiology
https://www.readbyqxmd.com/read/28605290/early-response-based-therapy-stratification-improves-survival-in-adult-early-thymic-precursor-acute-lymphoblastic-leukemia-a-group-for-research-on-adult-acute-lymphoblastic-leukemia-study
#20
Jonathan Bond, Carlos Graux, Ludovic Lhermitte, Diane Lara, Thomas Cluzeau, Thibaut Leguay, Agata Cieslak, Amélie Trinquand, Cedric Pastoret, Mohamed Belhocine, Salvatore Spicuglia, Véronique Lheritier, Stéphane Leprêtre, Xavier Thomas, Françoise Huguet, Norbert Ifrah, Hervé Dombret, Elizabeth Macintyre, Nicolas Boissel, Vahid Asnafi
Purpose Early thymic precursor (ETP) acute lymphoblastic leukemia (ALL) is an immunophenotypically defined subgroup of T-cell ALL (T-ALL) associated with high rates of intrinsic treatment resistance. Studies in children have shown that the negative prognostic impact of chemotherapy resistance is abrogated by the implementation of early response-based intensification strategies. Comparable data in adults are lacking. Patients and Methods We performed comprehensive clinicobiologic, genetic, and survival analyses of a large cohort of 213 adult patients with T-ALL, including 47 patients with ETP-ALL, treated in the GRAALL (Group for Research on Adult Acute Lymphoblastic Leukemia) -2003 and -2005 studies...
June 12, 2017: Journal of Clinical Oncology: Official Journal of the American Society of Clinical Oncology
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