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https://www.readbyqxmd.com/read/29453810/a-case-control-study-and-meta-analysis-reveal-the-association-between-cox-2-g-765c-polymorphism-and-primary-end-stage-hip-and-knee-osteoarthritis
#1
Wei Huang, Chen Deng, Feng Tian, Weilu Gao, Zhenfei Ding, Xianliang Rao, Zongsheng Yin
BACKGROUND: Osteoarthritis (OA) is a popular arthrosis featured as pain, limited joint activity, and deformity. Cyclooxygenase-2 (COX-2) has been reported to be up-regulated in arthritic tissues and is integral to the progression of osteoarthritis (OA). Previous studies showed the COX-2 promoter G-765C polymorphism could influence COX-2 expression. However, the relationship between the variant and OA risk is contrasting. METHODS: We conducted a case-control study with 196 primary end-stage hip and knee OA cases and 196 controls in a Chinese Han population...
February 17, 2018: Journal of Clinical Laboratory Analysis
https://www.readbyqxmd.com/read/29439887/a-challenge-for-mutation-specific-risk-stratification-in-long-qt-syndrome-type-1
#2
Noriaki Yagi, Hideki Itoh, Takashi Hisamatsu, Yukinori Tomita, Hiromi Kimura, Yusuke Fujii, Takeru Makiyama, Minoru Horie, Seiko Ohno
BACKGROUND: The relationship between mutation locations in KCNQ1 which is a major gene in long QT syndrome (LQTS) and phenotype has been analyzed and used for risk stratification. Mutations in the transmembrane region (TM) or cytoplasmic-loop (C-loop) are associated with more frequent cardiac events than those in other regions. However, accumulation of LQTS type 1 (LQT1) patients poses the question of whether the location specific risk stratification is really effective. METHODS: The study cohort consisted of 67 KCNQ1 mutation carriers and 13 family members who were suspected as having LQTS due to sudden cardiac death or syncope from 36 unrelated families...
February 10, 2018: Journal of Cardiology
https://www.readbyqxmd.com/read/29435002/tert-promoter-mutations-and-their-correlation-with-braf-and-ras-mutations-in-a-consecutive-cohort-of-145-thyroid-cancer-cases
#3
Andrea Cacciato Insilla, Agnese Proietti, Nicla Borrelli, Elisabetta Macerola, Cristina Niccoli, Paolo Vitti, Paolo Miccoli, Fulvio Basolo
Papillary thyroid carcinoma (PTC) is the most common type of endocrine malignancy and accounts for ~80% of thyroid carcinomas in adults and 90% in children. Risk stratification is important for identifying patients at higher risk and, for this reason, recent advances in molecular genetics of thyroid cancer can be applied to provide novel biomarkers useful in understanding tumor behavior. B-Raf proto-oncogene, serine/threonine kinase (BRAF) and rat sarcoma (RAS) mutations have been widely studied and appear to have an important role in thyroid tumorigenesis...
March 2018: Oncology Letters
https://www.readbyqxmd.com/read/29425227/interaction-between-polymorphisms-in-aspirin-metabolic-pathways-regular-aspirin-use-and-colorectal-cancer-risk-a-case-control-study-in-unselected-white-european-populations
#4
Harsh Sheth, Emma Northwood, Cornelia M Ulrich, Dominique Scherer, Faye Elliott, Jennifer H Barrett, David Forman, C Roland Wolf, Gillian Smith, Michael S Jackson, Mauro Santibanez-Koref, Robert Haile, Graham Casey, Mark Jenkins, Aung Ko Win, John L Hopper, Loic Le Marchand, Noralane M Lindor, Stephen N Thibodeau, John D Potter, John Burn, D Timothy Bishop
Regular aspirin use is associated with reduced risk of colorectal cancer (CRC). Variation in aspirin's chemoprevention efficacy has been attributed to the presence of single nucleotide polymorphisms (SNPs). We conducted a meta-analysis using two large population-based case-control datasets, the UK-Leeds Colorectal Cancer Study Group and the NIH-Colon Cancer Family Registry, having a combined total of 3325 cases and 2262 controls. The aim was to assess 42 candidate SNPs in 15 genes whose association with colorectal cancer risk was putatively modified by aspirin use, in the literature...
2018: PloS One
https://www.readbyqxmd.com/read/29417249/post-contrast-acute-kidney-injury-part-2-risk-stratification-role-of-hydration-and-other-prophylactic-measures-patients-taking-metformin-and-chronic-dialysis-patients-recommendations-for-updated-esur-contrast-medium-safety-committee-guidelines
#5
Aart J van der Molen, Peter Reimer, Ilona A Dekkers, Georg Bongartz, Marie-France Bellin, Michele Bertolotto, Olivier Clement, Gertraud Heinz-Peer, Fulvio Stacul, Judith A W Webb, Henrik S Thomsen
OBJECTIVES: The Contrast Media Safety Committee (CMSC) of the European Society of Urogenital Radiology (ESUR) has updated its 2011 guidelines on the prevention of post-contrast acute kidney injury (PC-AKI). The results of the literature review and the recommendations based on it, which were used to prepare the new guidelines, are presented in two papers. AREAS COVERED IN PART 2: Topics reviewed include stratification of PC-AKI risk, the need to withdraw nephrotoxic medication, PC-AKI prophylaxis with hydration or drugs, the use of metformin in diabetic patients receiving contrast medium and the need to alter dialysis schedules in patients receiving contrast medium...
February 7, 2018: European Radiology
https://www.readbyqxmd.com/read/29396714/prognostic-risk-models-for-transplant-decision-making-in-myelofibrosis
#6
Juan-Carlos Hernández-Boluda, Arturo Pereira, Juan-Gonzalo Correa, Alberto Alvarez-Larrán, Francisca Ferrer-Marín, José-María Raya, Joaquín Martínez-López, Patricia Velez, Manuel Pérez-Encinas, Natalia Estrada, Valentín García-Gutiérrez, María-Laura Fox, Angel Payer, Ana Kerguelen, Beatriz Cuevas, María-Antonia Durán, María-José Ramírez, María-Teresa Gómez-Casares, María-Isabel Mata-Vázquez, Elvira Mora, Montse Gómez, Francisco Cervantes
Prognostic models are widely used in clinical practice for transplant decision-making in myelofibrosis (MF). We have compared the performance of the International Prognostic Scoring System (IPSS), dynamic IPSS (DIPSS), and DIPSS-plus in a series of 544 patients with primary or secondary MF aged ≤ 70 years at the time of diagnosis. The median projected survival of the overall series was 9.46 years (95% confidence interval 7.44-10.59). Median survival for the highest risk groups was less than 4 years in the three prognostic models...
January 25, 2018: Annals of Hematology
https://www.readbyqxmd.com/read/29390229/feasibility-of-a-single-contrast-bolus-high-pitch-pulmonary-ct-angiography-protocol-followed-by-low-dose-retrospectively-ecg-gated-cardiac-ct-in-patients-with-suspected-pulmonary-embolism
#7
Julia Carmen Schäfer, Holger Haubenreisser, Mathias Meyer, Joachim Grüttner, Thomas Walter, Martin Borggrefe, Joseph U Schoepf, John W Nance, Stefan O Schönberg, Thomas Henzler
INTRODUCTION:  To prospectively evaluate the feasibility of single contrast bolus high-pitch CT pulmonary angiography (CTPA) subsequently followed by low-dose retrospectively ECG-gated cardiac CT (4D-cCT) in patients with suspected pulmonary embolism (PE) to accurately evaluate right ventricular (RV) function. MATERIALS AND METHODS:  62 patients (33 female, age 65.1 ± 17.5 years) underwent high-pitch CTPA examination with 80cc of iodinated contrast material...
February 1, 2018: RöFo: Fortschritte Auf Dem Gebiete der Röntgenstrahlen und der Nuklearmedizin
https://www.readbyqxmd.com/read/29374742/associations-between-pet-textural-features-and-glut1-expression-and-the-prognostic-significance-of-textural-features-in-lung-adenocarcinoma
#8
Young Wha Koh, Seong Yong Park, Seung Hyup Hyun, Su Jin Lee
BACKGROUND/AIM: We evaluated the association between positron emission tomography (PET) textural features and glucose transporter 1 (GLUT1) expression level and further investigated the prognostic significance of textural features in lung adenocarcinoma. PATIENTS AND METHODS: We evaluated 105 adenocarcinoma patients. We extracted texture-based PET parameters of primary tumors. Conventional PET parameters were also measured. The relationships between PET parameters and GLUT1 expression levels were evaluated...
February 2018: Anticancer Research
https://www.readbyqxmd.com/read/29372125/dilated-thoracic-esophagus-presenting-with-painful-progressive-persistent-dysphagia-and-leukocytosis-of-unknown-origin
#9
Kyawzaw Lin, Jamil Shah, Emmanuel Ofori, Vahe Shahnazarian, Madhavi Reddy
Esophageal cancer is the eighth-most common cause of cancer-related mortality worldwide. The most common presenting symptom in advanced distal esophageal cancer is the sensation of sticking food, but it may sometimes present with bleeding and related complications, or asymptomatic leukocytosis. We present the case of a 77-year-old afebrile man with chronic alcoholism and a dilated thoracic esophagus with painful, progressive, and persistent dysphagia and leukocytosis of unknown origin. A 77-year-old man with a past medical history of hypertension and colonic cancer status post right hemicolectomy (surveillance negative) presented to the emergency department with painful, progressive, persistent, and worsening dysphagia for the past three weeks...
November 16, 2017: Curēus
https://www.readbyqxmd.com/read/29370361/hyperhomocysteinemia-and-risk-of-first-venous-thrombosis-the-influence-of-unmeasured-confounding-factors
#10
Monica Ospina-Romero, Suzanne C Cannegieter, Martin den Heijer, Carine J M Doggen, Frits R Rosendaal, Willem M Lijfering
Meta-analyses have reported a 2-3 fold increased risk of venous thrombosis (VT) in individuals with hyperhomocysteinemia, however, confounding factors were generally not considered. In contrast, randomized trials of homocysteine-lowering therapy and VT risk were negative. We investigated if hyperhomocysteinemia is associated with VT in the MEGA case-control study (1999-2004) from the Netherlands (1,689 cases and 1,726 controls), taking into account measured and unmeasured confounders. We compared patients with population controls to estimate odds ratios (OR) by unconditional logistic regression and adjusted for various potential confounders...
January 12, 2018: American Journal of Epidemiology
https://www.readbyqxmd.com/read/29362152/peripheral-zone-lesions-of-intermediary-risk-in-multiparametric-prostate-mri-frequency-and-validation-of-the-pi-radsv2-risk-stratification-algorithm-based-on-focal-contrast-enhancement
#11
Matthias Benndorf, Lorenz Waibel, Malte Krönig, Cordula Annette Jilg, Mathias Langer, Tobias Krauss
PURPOSE: To validate the risk stratification algorithm of the Prostate Imaging Reporting and Data System (PI-RADSv2) for intermediary risk lesions (PI-RADSv2 category 3) in the peripheral zone based on focal contrast enhancement and to compare cancer rates in category 3, upgraded category 4 and category 4 based on markedly low ADC value. MATERIALS AND METHODS: We retrospectively analyze 172 consecutive patients undergoing prostate MRI with 315 histopathologically verified lesions...
February 2018: European Journal of Radiology
https://www.readbyqxmd.com/read/29344009/evaluation-of-nipple-aspirate-fluid-as-a-diagnostic-tool-for-early-detection-of-breast-cancer
#12
REVIEW
Sadr-Ul Shaheed, Catherine Tait, Kyriacos Kyriacou, Richard Linforth, Mohamed Salhab, Chris Sutton
There has been tremendous progress in detection of breast cancer in postmenopausal women, resulting in two-thirds of women surviving more than 20 years after treatment. However, breast cancer remains the leading cause of cancer-related deaths in premenopausal women. Breast cancer is increasing in younger women due to changes in life-style as well as those at high risk as carriers of mutations in high-penetrance genes. Premenopausal women with breast cancer are more likely to be diagnosed with aggressive tumours and therefore have a lower survival rate...
2018: Clinical Proteomics
https://www.readbyqxmd.com/read/29323247/leakage-correction-improves-prognosis-prediction-of-dynamic-susceptibility-contrast-perfusion-mri-in-primary-central-nervous-system-lymphoma
#13
Yeon Soo Kim, Seung Hong Choi, Roh-Eul Yoo, Koung Mi Kang, Tae Jin Yun, Ji-Hoon Kim, Chul-Ho Sohn, Sung-Hye Park, Jae-Kyung Won, Tae Min Kim, Chul-Kee Park, Il Han Kim
To evaluate whether the cerebral blood volume (CBV) measurement with leakage correction from dynamic susceptibility contrast perfusion weighted imaging can be useful in predicting prognosis for primary central nervous system lymphoma (PCNSL). 46 PCNSL patients were included and classified by radiation therapy (RT) stratification into RT (n = 30) and non-RT (n = 16) groups. The corresponding histogram parameters of normalized CBV (nCBV) maps with or without leakage correction were calculated on contrast-enhanced T1 weighted image (CE T1WI) or on fluid attenuated inversion recovery image...
January 11, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29311548/author-correction-targeted-gadofullerene-for-sensitive-magnetic-resonance-imaging-and-risk-stratification-of-breast-cancer
#14
Zheng Han, Xiaohui Wu, Sarah Roelle, Chuheng Chen, William P Schiemann, Zheng-Rong Lu
In the original version of this Article, the penultimate sentence of the Abstract incorrectly read 'The dose of the contrast agent for effective molecular MRI is only slightly lower than that of ZD2-Cy5.5 (0.5 µmol kg-1) in fluorescence imaging.' The correct version states 'higher' in place of 'lower'. This error has been corrected in both the PDF and HTML versions of the Article.
January 8, 2018: Nature Communications
https://www.readbyqxmd.com/read/29279888/prevalence-of-systemic-atherosclerosis-burdens-and-overlapping-stroke-etiologies-and-their-associations-with-long-term-vascular-prognosis-in-stroke-with-intracranial-atherosclerotic-disease
#15
Takao Hoshino, Leila Sissani, Julien Labreuche, Gregory Ducrocq, Philippa C Lavallée, Elena Meseguer, Céline Guidoux, Lucie Cabrejo, Cristina Hobeanu, Fernando Gongora-Rivera, Pierre-Jean Touboul, Philippe Gabriel Steg, Pierre Amarenco
Importance: Patients who have experienced stroke with intracranial atherosclerotic disease (ICAD) may also have concomitant atherosclerosis in different arterial beds and other possible causes for ischemic stroke. However, little is known about the frequency and prognostic effect of such overlapping diseases. Objectives: To describe the prevalence of systemic atherosclerotic burdens and overlapping stroke etiologies and their contributions to long-term prognoses among patients who have experienced stroke with ICAD...
December 26, 2017: JAMA Neurology
https://www.readbyqxmd.com/read/29259814/diagnosis-of-psychosocial-risk-factors-in-prevention-of-low-back-pain-in-athletes-mispex
#16
Pia-Maria Wippert, Anne-Katrin Puschmann, Adamantios Arampatzis, Marcus Schiltenwolf, Frank Mayer
Background: Low back pain (LBP) is a common pain syndrome in athletes, responsible for 28% of missed training days/year. Psychosocial factors contribute to chronic pain development. This study aims to investigate the transferability of psychosocial screening tools developed in the general population to athletes and to define athlete-specific thresholds. Methods: Data from a prospective multicentre study on LBP were collected at baseline and 1-year follow-up (n=52 athletes, n=289 recreational athletes and n=246 non-athletes)...
2017: BMJ Open Sport & Exercise Medicine
https://www.readbyqxmd.com/read/29246722/development-and-validation-of-a-predictive-radiomics-model-for-clinical-outcomes-in-stage-i-non-small-cell-lung-cancer
#17
Wen Yu, Chad Tang, Brian P Hobbs, Xiao Li, Eugene J Koay, Ignacio I Wistuba, Boris Sepesi, Carmen Behrens, Jaime Rodriguez Canales, Edwin Roger Parra Cuentas, Jeremy J Erasmus, Laurence E Court, Joe Y Chang
PURPOSE: To develop and validate a radiomics signature that can predict the clinical outcomes for patients with stage I non-small cell lung cancer (NSCLC). METHODS AND MATERIALS: We retrospectively analyzed contrast-enhanced computed tomography images of patients from a training cohort (n = 147) treated with surgery and an independent validation cohort (n = 295) treated with stereotactic ablative radiation therapy. Twelve radiomics features with established strategies for filtering and preprocessing were extracted...
November 15, 2017: International Journal of Radiation Oncology, Biology, Physics
https://www.readbyqxmd.com/read/29246451/molecular-insights-into-the-classification-of-high-grade-endometrial-carcinoma
#18
REVIEW
Yaser R Hussein, Robert A Soslow
Endometrial carcinoma, which is associated with a mortality rate of approximately 20%, is the most common gynecological malignancy in the Western world. It is a heterogeneous disease, with multiple histotypes, each constituting a different disease entity. However, interobserver diagnostic agreement is suboptimal, particularly among the most lethal histotypes. Most recent data also indicate that histotype assignment is not independently associated with survival, while in contrast, clinicopathological risk stratification and genomic classification are significantly prognostic...
December 12, 2017: Pathology
https://www.readbyqxmd.com/read/29239257/cardiac-magnetic-resonance-assessment-of-diastolic-dysfunction-in-acute-coronary-syndrome
#19
Shah M Azarisman, Karen S Teo, Matthew I Worthley, Stephen G Worthley
Chest pain is an important presenting symptom. However, few cases of chest pain are diagnosed as acute coronary syndrome (ACS) in the acute setting. This results in frequent inappropriate discharge and major delay in treatment for patients with underlying ACS. The conventional methods of assessing ACS, which include electrocardiography and serological markers of infarct, can take time to manifest. Recent studies have investigated more sensitive and specific imaging modalities that can be used. Diastolic dysfunction occurs early following coronary artery occlusion and its detection is useful in confirming the diagnosis, risk stratification, and prognosis post-ACS...
December 2017: Journal of International Medical Research
https://www.readbyqxmd.com/read/29230958/treatment-related-mortality-in-relapsed-childhood-acute-lymphoblastic-leukemia
#20
Trausti Oskarsson, Stefan Söderhäll, Johan Arvidson, Erik Forestier, Thomas Leth Frandsen, Marit Hellebostad, Päivi Lähteenmäki, Ólafur G Jónsson, Ida Hed Myrberg, Mats Heyman
BACKGROUND: Treatment of relapsed childhood acute lymphoblastic leukemia (ALL) is particularly challenging due to the high treatment intensity needed to induce and sustain a second remission. To improve results, it is important to understand how treatment-related toxicity impacts survival. PROCEDURE: In this retrospective population-based study, we described the causes of death and estimated the risk for treatment-related mortality in patients with first relapse of childhood ALL in the Nordic Society of Paediatric Haematology and Oncology ALL-92 and ALL-2000 trials...
December 12, 2017: Pediatric Blood & Cancer
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