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https://www.readbyqxmd.com/read/29600239/clinical-outcome-study-of-crizotinib-in-immunohistochemistry-proven-echinoderm-microtubule-associated-protein-like-4-anaplastic-lymphoma-kinase-fusion-gene-among-indian-patients-with-adenocarcinoma-lung
#1
Ullas Batra, Mohit Aggarwal, Parveen Jain, Pankaj Goyal, Abhishek Yadav, Udip Maheshwari, Anurag Mehta
Aims: The anaplastic lymphoma kinase (ALK) Break Apart FISH Probe Kit and Ventana anti-ALK (D5F3) CDx immunohistochemistry (IHC) assay are the Food and Drug Administration-approved companion diagnostic for targeted therapy with the ALK inhibitor crizotinib in lung cancers. The aim of this study was to assess the efficacy and safety of twice daily crizotinib tablet (250 mg) in IHC-proven echinoderm microtubule-associated protein-like 4 (EML4)-ALK fusion gene among Indian patients with adenocarcinoma lung in the routine clinical practice...
January 2018: South Asian Journal of Cancer
https://www.readbyqxmd.com/read/29578911/adrenal-metastasectomy-in-the-presence-and-absence-of-extraadrenal-metastatic-disease
#2
Ashley E Russo, Brian R Untch, Mark G Kris, Joanne F Chou, Marinela Capanu, Daniel G Coit, Jamie E Chaft, Michael I D'Angelica, Murray F Brennan, Vivian E Strong
OBJECTIVE: To determine if there are differences in overall survival (OS) or event-free survival (EFS) in patients with and without concomitant extra-adrenal metastases undergoing adrenal metastasectomy. BACKGROUND: There is growing interest in the use of local therapies in patients with oligometastatic disease. Previously published series have indicated that long-term survival is possible with resection. Adrenalectomy has been used to treat adrenal metastases in select patients...
March 23, 2018: Annals of Surgery
https://www.readbyqxmd.com/read/29578164/phosphatase-and-tensin-homolog-protein-may-be-linked-to-lymph-node-metastasis-and-tumor-node-metastasis-staging-in-nonsmall-cell-lung-cancer
#3
Zhi-Yong Ji, Hai-Feng Li, Yu Lei, Yan-Wei Rao, Ming-Li Sun, Xin-Wei Wang, Yan-Lin Zhang
Background: This study aims to investigate the correlations of positive rate of phosphatase and tensin homolog (PTEN) protein with lymph node metastasis (LNM) and tumor node metastasis (TNM) staging of nonsmall cell lung cancer (NSCLC) patients by conducted a meta-analysis. Materials and Methods: Covering several electronic databases (Embase, Cochrane Library, China BioMedicine, China National Knowledge Infrastructure, PubMed, and Web of Science), published papers eligible for enrollment in the current meta-analysis had to fulfill our predefined selection criteria...
2018: Journal of Cancer Research and Therapeutics
https://www.readbyqxmd.com/read/29578158/effect-of-spleen-tyrosine-kinase-on-nonsmall-cell-lung-cancer
#4
Ying Tao Hao, Chuan Liang Peng, Yun Peng Zhao, Qi Feng Sun, Xiao Gang Zhao, Bo Cong
Aim of Study: To investigate the anti.tumor effect of spleen tyrosine kinase. (Syk) on the human nonsmall cell lung cancer cells in vitro and its mechanism. Materials and Methods: In this study, we constructed a eukaryotic expression vector pcDNA3.1D/V5-His-TOPO/Syk and transfected it into human nonsmall cell lung cancer cells A549. Then, we not only analyzed the expression of Syk in transfected cells and its invasion but also the expression of matrix metalloproteinase-9 (MMP-9)...
2018: Journal of Cancer Research and Therapeutics
https://www.readbyqxmd.com/read/29578153/dual-specificity-phosphatase-6-genetic-variants-associated-with-risk-of-lung-squamous-cell-carcinoma-in-han-chinese
#5
Tian-Lu Wang, Ying-Qiu Song, Yang-Wu Ren, Bao-Sen Zhou, He-Tong Wang, Ya Gao, Hong Yu, Yu-Xia Zhao
Background: Nonsmall cell lung cancer (NSCLC) mainly contains adenocarcinoma (AC) and squamous cell carcinoma (SqCC). This study investigated single nucleotide polymorphism (SNP) of topoisomerase II alpha (TOP2A) and dual-specificity phosphatase 6 (DUSP6) in a hospital-based case and control cohort of individuals for association with risk of different histological subtypes of NSCLC. Materials and Methods: A total of 454 (237 SqCC and 217 AC) NSCLC patients, and 454 healthy controls were recruited for analysis of TOP2A rs471692 and DUSP6 rs2279574 genotypes using the TaqMan polymerase chain reaction technique...
2018: Journal of Cancer Research and Therapeutics
https://www.readbyqxmd.com/read/29578152/death-associated-protein-kinase-promoter-methylation-correlates-with-clinicopathological-and-prognostic-features-in-nonsmall-cell-lung-cancer-patients-a-cohort-study
#6
Xiao-Yu Yang, Jun Zhang, Xiao-Ling Yu, Guo-Feng Zheng, Fei Zhao, Xiao-Jing Jia
Objective: The objective was to study the correlation between death-associated protein kinase (DAPK) promoter methylation and the clinicopathological and prognostic features in nonsmall cell lung cancer (NSCLC) patients. Materials and Methods: A total of 117 NSCLC patients were recruited into our study between December 2012 and December 2014. Methylation-specific polymerase chain reaction was employed to detect the methylation status of DAPK in cancer tissues, peficancerous tissues, and serum samples of 117 NSCLC patients...
2018: Journal of Cancer Research and Therapeutics
https://www.readbyqxmd.com/read/29578147/comparison-of-the-efficacy-of-strontium-89-chloride-in-treating-bone-metastasis-of-lung-breast-and-prostate-cancers
#7
Xiaojuan Ye, Da Sun, Cen Lou
Objective: The aim of this study was to comparatively evaluate the efficacy of strontium-89 chloride (89 SrCl2 ) in treating bone metastasis-associated pain in patients with lung, breast, or prostate cancer. Materials and Methods: The 126 patients with lung cancer included 88, 16, 15, 4, and 3 patients with adenocarcinoma, squamous cell carcinoma, nonsmall cell carcinoma, mixed carcinoma, and small cell carcinoma, respectively, and the control group consisted of patients with breast (71 patients) or prostate cancer (49 patients) who underwent89 SrCl2 treatment during the same period...
2018: Journal of Cancer Research and Therapeutics
https://www.readbyqxmd.com/read/29573236/efficacy-safety-and-predictive-indicators-of-apatinib-after-multilines-treatment-in-advanced-nonsquamous-nonsmall-cell-lung-cancer-apatinib-treatment-in-nonsquamous-nsclc
#8
Di Wu, Li Liang, Ligong Nie, Jun Nie, Ling Dai, Weiheng Hu, Jie Zhang, Xiaoling Chen, Jindi Han, Xiangjuan Ma, Guangming Tian, Sen Han, Jieran Long, Yang Wang, Ziran Zhang, Tao Xin, Jian Fang
AIM: Patients with advanced nonsquamous nonsmall cell lung cancer (NSCLC) who experienced progression with two or more lines chemotherapy have no treatment options that clearly confer a survival benefit. As a novel vascular endothelial growth factor receptor-2 tyrosine kinase inhibitor, apatinib has a certain antitumor effect for various solid tumors. The present study evaluated the efficacy and safety of apatinib in advanced nonsquamous NSCLC as salvage treatment in Chinese real-world practice...
March 24, 2018: Asia-Pacific Journal of Clinical Oncology
https://www.readbyqxmd.com/read/29567880/myeloid-cell-leukemia-1-protein-expression-and-myeloid-cell-leukemia-1-gene-amplification-in-non-small-cell-lung-cancer
#9
Tony El Jabbour, Siddhartha Dilip Dalvi, Sungeun Kim, Christine Sheehan, Jeffrey S Ross
Background: Myeloid cell leukemia-1 (Mcl-1) is a member of the B-cell lymphoma 2 family known to play a significant role in the regulation of apoptosis. Mcl-1 expression has been studied in nonsmall cell lung cancer (NSCLC) cell lines but has not been previously evaluated as a prognostic factor in clinical samples. Materials and Methods: Formalin-fixed, paraffin-embedded sections from 119 NSCLC, including 33 squamous cell carcinomas (SCC), 55 adenocarcinomas (AC), and 31 either pure adenocarcinoma in situ (AIS) or AC with lepidic features were immunostained by an automated method with rabbit polyclonal Mcl-1...
January 2018: Indian Journal of Pathology & Microbiology
https://www.readbyqxmd.com/read/29552768/the-expression-and-mechanism-of-sirt1-and-ampk-in-nonsmall-cell-lung-cancer
#10
Fushen Yang
PURPOSE: To investigate the expression of sirtuin type 1 (Sirt1) and adenosine 5'-monophosphate (AMP)-activated protein kinase (AMPK) in non-small cell lung cancer (NSCLC), and to explore the mechanism of their functions in NSCLC. METHODS: Cancer tissues (NSCLC group) and the adjacent normal healthy tissues (control group) of 50 patients with NSCLC were selected, and H&E staining was performed to identify the histopathological differences. Reverse transcription polymerase chain reaction (RT-PCR), immunofluorescence staining and Western blot were performed to detect the expression of Sirt1 and AMPK in tissues of NSCLC group and control group...
January 2018: Journal of B.U.ON.: Official Journal of the Balkan Union of Oncology
https://www.readbyqxmd.com/read/29545318/cost-effectiveness-of-kras-egfr-and-alk-testing-for-decision-making-in-advanced-nonsmall-cell-lung-carcinoma-the-french-ifct-predict-amm-study
#11
Sandrine Loubière, Alexandre Drezet, Michèle Beau-Faller, Denis Moro-Sibilot, Sylvie Friard, Marie Wislez, Hélène Blons, Catherine Daniel, Virginie Westeel, Anne Madroszyk, Hervé Léna, Patrick Merle, Julien Mazières, Gérard Zalcman, Roger Lacave, Martine Antoine, Franck Morin, Pascale Missy, Fabrice Barlesi, Pascal Auquier, Jacques Cadranel
ALK rearrangement and EGFR / KRAS mutations constitute the primary biomarkers tested to provide targeted or nontargeted therapies in advanced nonsmall cell lung cancer (NSCLC) patients. Our objective was to assess the cost-effectiveness of biomarker testing for NSCLC.Between 2013 and 2014, 843 treatment-naive patients were prospectively recruited at 19 French hospitals into a longitudinal observational cohort study. Two testing strategies were compared, i.e. with "at least one biomarker status known" and "at least KRAS status known", in addition to "no biomarker testing" as the reference strategy...
March 2018: European Respiratory Journal: Official Journal of the European Society for Clinical Respiratory Physiology
https://www.readbyqxmd.com/read/29521657/stereotactic-ablative-radiation-therapy-in-lung-cancer-an-emerging-standard
#12
Adam Mutsaers, Hanbo Chen, Alexander V Louie
PURPOSE OF REVIEW: Significant advances have been made in the field of stereotactic ablative radiotherapy (SABR) for the treatment of pulmonary neoplasms in recent years. This review aims to summarize recent salient evidence on SABR for early-stage nonsmall cell lung cancer (ES-NSCLC). RECENT FINDINGS: In medically inoperable patients, SABR remains the standard of care. The optimal SABR dosing regimen is being studied. Comparisons with non-SABR radiotherapy regimens with lower doses per fraction revealed benefit of SABR...
March 7, 2018: Current Opinion in Pulmonary Medicine
https://www.readbyqxmd.com/read/29517684/cxcl14-and-nos1-expression-in-specimens-from-patients-with-stage-i-iiia-nonsmall-cell-lung-cancer-after-curative-resection
#13
Xiaoqin Ji, Zetian Shen, Benxin Zhao, Xi Yuan, Xixu Zhu
Many studies show that CXC chemokine ligand 14 (CXCL14) is highly expressed in tumor-associated stromal cells, promoting tumor cell growth, and invasion. Because of its unclear receptors, CXCL14-initiated intracellular signal cascades remain largely unknown. However, CXCL14 can regulate nitric oxide synthase 1 (NOS1) as its intracellular molecular target. In this paper, we investigated the expression of CXCL14 and NOS1 in specimens from patients with stage I-IIIA nonsmall cell lung cancer (NSCLC) after curative resection, and evaluated the prognostic significance of this gene expression in stromal fibroblasts and cancer cells...
March 2018: Medicine (Baltimore)
https://www.readbyqxmd.com/read/29516980/apatinib-for-advanced-nonsmall-cell-lung-cancer-a-retrospective-case-series-analysis
#14
Chengxi Yang, Wen Feng, Di Wu
Objectives: Apatinib, a tyrosine kinase inhibitor which selectively inhibits vascular endothelial growth factor receptor-2, has been shown to be beneficial to patients with a variety of cancers, including advanced nonsmall-cell lung cancer (NSCLC). Thus, this study was aimed to retrospectively assess the efficacy and safety of apatinib in patients with advanced/metastatic NSCLC who failed more than two lines of treatment. Methods: Twenty-three NSCLC patients were involved in this study, who received oral apatinib at a daily dose of 250/500/750 mg, with the progression after the failure of second-line therapy...
January 2018: Journal of Cancer Research and Therapeutics
https://www.readbyqxmd.com/read/29516976/meta-analysis-of-adjuvant-chemotherapy-versus-surgery-alone-in-t2an0-stage-ib-non-small-cell-lung-cancer
#15
Tianxiang Zhang, Qiang Guo, Ye Zhang, Zhidong Liu, Shijie Zhou, Shaofa Xu
Background: Although there is a strong evidence that adjuvant chemotherapy after surgery was effective in Stages II and IIIA patients involved nonsmall cell lung cancer (NSCLC), its eligibility in Stage IB disease has been unknown. Therefore, this meta-analysis was aimed to compare the effects of adjuvant chemotherapy versus surgery alone in patients with Stage IB NSCLC. Materials and Methods: We systematically searched for articles from their inclusion to July 2016...
January 2018: Journal of Cancer Research and Therapeutics
https://www.readbyqxmd.com/read/29516954/heparan-sulfate-d-glucosamine-3-o-sulfotransferase-3b1-is-a-novel-regulator-of-transforming-growth-factor-beta-mediated-epithelial-to-mesenchymal-transition-and-regulated-by-mir-218-in-nonsmall-cell-lung-cancer
#16
Zengli Zhang, Hanyi Jiang, Yongsheng Wang, Minhua Shi
Background: Due to high metastasis and recurrence rate. Recent studies indicated that epithelial-to-mesenchymal transition (EMT) was involved in the progression and metastasis in cancer. Some reports also indicate that HS3ST3B1 played a role in angiogenesis and the proliferation of cancer cells. In this study, we aim to investigate its role in non-small cell lung cancer (NSCLC) . Materials and Methods: All cell lines were purchased from ATCC and cultured in our central lab...
January 2018: Journal of Cancer Research and Therapeutics
https://www.readbyqxmd.com/read/29509251/enhanced-expression-of-non-coding-mir-92a-expression-is-implicated-in-the-development-of-lung-cancer
#17
Q Zhu, Q Zang, Z-M Jiang
OBJECTIVE: MicroRNAs (miRNAs/miRs) are small noncoding RNAs that primarily function in RNA silencing and gene regulation at the posttranscriptional level in animals, plants and certain viruses. They have been reported to play a vital role in development and progression of diseases such as cancer. The present study was undertaken to establish a correlation between a specific miRNA in this cluster, termed miR92a, and its association with nonsmall cell lung cancer (NSCLC). MATERIALS AND METHODS: Total RNA was isolated from the plasma using an RNeasy mini kit and cDNA was synthesized by TaqMan MicroRNA Reverse Transcription kit...
February 2018: European Review for Medical and Pharmacological Sciences
https://www.readbyqxmd.com/read/29504181/comparison-of-3-he-and-129-xe-mri-for-evaluation-of-lung-microstructure-and-ventilation-at-1-5t
#18
Neil J Stewart, Ho-Fung Chan, Paul J C Hughes, Felix C Horn, Graham Norquay, Madhwesha Rao, Denise P Yates, Rob H Ireland, Matthew Q Hatton, Bilal A Tahir, Paul Ford, Andrew J Swift, Rod Lawson, Helen Marshall, Guilhem J Collier, Jim M Wild
BACKGROUND: To support translational lung MRI research with hyperpolarized129 Xe gas, comprehensive evaluation of derived quantitative lung function measures against established measures from3 He MRI is required. Few comparative studies have been performed to date, only at 3T, and multisession repeatability of129 Xe functional metrics have not been reported. PURPOSE/HYPOTHESIS: To compare hyperpolarized129 Xe and3 He MRI-derived quantitative metrics of lung ventilation and microstructure, and their repeatability, at 1...
March 5, 2018: Journal of Magnetic Resonance Imaging: JMRI
https://www.readbyqxmd.com/read/29501212/immunotherapy-as-a-treatment-for-biliary-tract-cancers-a-review-of-approaches-with-an-eye-to-the-future
#19
REVIEW
Alex B Blair, Adrian Murphy
Biliary tract cancers (BTC) are aggressive malignancies associated with resistance to chemotherapy and poor prognostic rates. Therefore, novel treatment approaches are in need. Immunotherapy represents a promising breakthrough that uses a patient's immune system to target a tumor. This treatment approach has shown immense progress with positive results for selected cancers such as melanoma and nonsmall cell lung cancer. Initial preclinical data and preliminary clinical studies suggest encouraging mechanistic effects for immunotherapy in BTC offering the hope for an expanding therapeutic role for this disease...
October 31, 2017: Current Problems in Cancer
https://www.readbyqxmd.com/read/29487253/paclitaxel-induced-dermal-hypersensitivity-lesions-2-deoxy-2-18f-fluoro-d-glucose-positron-emission-tomography-computed-tomography
#20
Inci Uslu Biner, Ebru Tatci, Berna Akinci Ozyurek, Ozlem Ozmen
Paclitaxel is frequently used for the treatment of patients with nonsmall cell lung cancer. Hypersensitivity reactions (HSRs) have been one of the toxicities observed with administration of paclitaxel. Here, we presented a case of a 49-year-old man with a history of right lung mass proven by biopsy to be a nonsmall cell lung cancer (squamous cell carcinoma) who developed HSR during therapy. In addition to the hypermetabolic primary malignancy, a positron emission tomography/computed tomography (PET/CT) scan showed multiple hypermetabolic skin lesions at several parts of the body...
March 2018: Lung India: Official Organ of Indian Chest Society
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