Yulei Wei, E Zhang, Leqian Yu, Baiquan Ci, Masahiro Sakurai, Lei Guo, Xin Zhang, Sirui Lin, Shino Takii, Lizhong Liu, Jian Liu, Daniel A Schmitz, Ting Su, Junmei Zhang, Qiaoyan Shen, Yi Ding, Linfeng Zhan, Hai-Xi Sun, Canbin Zheng, Lin Xu, Daiji Okamura, Weizhi Ji, Tao Tan, Jun Wu
Embryogenesis necessitates harmonious coordination between embryonic and extraembryonic tissues. Although stem cells of both embryonic and extraembryonic origins have been generated, they are grown in different culture conditions. In this study, utilizing a unified culture condition that activates the FGF, TGF-β, and WNT pathways, we have successfully derived embryonic stem cells (FTW-ESCs), extraembryonic endoderm stem cells (FTW-XENs), and trophoblast stem cells (FTW-TSCs) from the three foundational tissues of mouse and cynomolgus monkey (Macaca fascicularis) blastocysts...
November 24, 2023: Cell