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https://www.readbyqxmd.com/read/28716528/treatment-with-trek1-and-trpc3-6-ion-channel-inhibitors-upregulates-microrna-expression-in-a-mouse-model-of-chronic-mild-stress
#1
İlay Buran, Ebru Önalan Etem, Ahmet Tektemur, Halit Elyas
Depression is a common mental disorder characterized by the mood of deep sadness. Recent studies have demonstrated that microRNAs and ion channels have significant roles in the etiopathogenesis of depression. Therefore, we investigated the effects of the TREK1 ion channel inhibitor anandamide and the TRPC3/6 inhibitor norgestimate on microRNA expression and antidepressant effect in the mouse chronic mild stress (CMS) model of depression. Male BALB/c mice were divided into groups as control, CMS, CMS+sertraline, CMS+anandamide, CMS+sertraline+anandamide, CMS+norgestimate and CMS+sertraline+norgestimate...
July 14, 2017: Neuroscience Letters
https://www.readbyqxmd.com/read/28714388/the-prospective-role-of-micrornas-in-depression
#2
Zhiying Hu, Yuting Jiang, Xue Huo, Yang Yang, Henry Davies, Benson O A Botchway, Marong Fang
Depression is a debilitating disease that is affecting a growing number of patients both physically and mentally. In addition to the mood changes, depression causes cognitive impairment, including learning and memory dysfunction. Although depression studies have been going on for decades, the underlying mechanism still remains unclear. MicroRNAs (miRNAs), a type of small non-coding RNAs, predominantly control the expression of their target mRNAs to exert their functions. Some evidence has revealed the importance of miRNAs in the mechanism of depression though the studies are still in their infancy...
July 14, 2017: Current Medicinal Chemistry
https://www.readbyqxmd.com/read/28704935/entrainment-of-breast-cell-lines-results-in-rhythmic-fluctuations-of-micrornas
#3
Rafael Chacolla-Huaringa, Jorge Moreno-Cuevas, Victor Trevino, Sean-Patrick Scott
Circadian rhythms are essential for temporal (~24 h) regulation of molecular processes in diverse species. Dysregulation of circadian gene expression has been implicated in the pathogenesis of various disorders, including hypertension, diabetes, depression, and cancer. Recently, microRNAs (miRNAs) have been identified as critical modulators of gene expression post-transcriptionally, and perhaps involved in circadian clock architecture or their output functions. The aim of the present study is to explore the temporal expression of miRNAs among entrained breast cell lines...
July 12, 2017: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/28689715/exploration-of-low-temperature-microrna-function-in-an-anoxia-tolerant-vertebrate-ectotherm-the-red-eared-slider-turtle-trachemys-scripta-elegans
#4
Kyle K Biggar, Kenneth B Storey
As a model for vertebrate long-term survival in oxygen-restricted environments, the red-eared slider turtle (Trachemys scripta elegans) can adapt at the biochemical level to survive in oxygen-free (anoxic) cold water (<10°C). This impressive ability is enabled through a coordinated suppression of energy-expensive, non-essential, cell processes. This study explored the anoxia-responsive expression of several microRNA species (miR-1a, -133, -17, -107, -148a, -21, -103, -210, -20a, -365 and -29b) in adult turtles exposed to 5h and 20h anoxia (at 5±1°C)...
August 2017: Journal of Thermal Biology
https://www.readbyqxmd.com/read/28687876/chromosome-21-encoded-micrornas-mrnas-impact-on-down-s-syndrome-and-trisomy-21-linked-disease
#5
P N Alexandrov, M E Percy, Walter J Lukiw
Down's syndrome (DS; also known as trisomy 21; T21) is caused by a triplication of all or part of human chromosome 21 (chr21). DS is the most common genetic cause of intellectual disability attributable to a naturally-occurring imbalance in gene dosage. DS incurs huge medical, healthcare, and socioeconomic costs, and there are as yet no effective treatments for this incapacitating human neurogenetic disorder. There is a remarkably wide variability in the 'phenotypic spectrum' associated with DS; the progression of symptoms and the age of DS onset fluctuate, and there is further variability in the biophysical nature of the chr21 duplication...
July 7, 2017: Cellular and Molecular Neurobiology
https://www.readbyqxmd.com/read/28673667/circulating-micrornas-as-biomarkers-for-depression-many-candidates-few-finalists
#6
REVIEW
Heidi Yuan, David Mischoulon, Maurizio Fava, Michael W Otto
BACKGROUND: Recent research has highlighted the potential of microRNAs to serve as physiological indicators of disease process among clinically depressed patients. METHODS: In a comprehensive literature search through PubMed, we identified 23 articles comparing circulating (blood, plasma, or serum) microRNA expression levels in depressed versus healthy human subjects. Six studies examining circulatory microRNA expression through animal models of depression were also identified through the search and details of each study were outlined...
June 27, 2017: Journal of Affective Disorders
https://www.readbyqxmd.com/read/28654094/inflammation-and-vascular-remodeling-in-the-ventral-hippocampus-contributes-to-vulnerability-to-stress
#7
J Pearson-Leary, D Eacret, R Chen, H Takano, B Nicholas, S Bhatnagar
During exposure to chronic stress, some individuals engage in active coping behaviors that promote resiliency to stress. Other individuals engage in passive coping that is associated with vulnerability to stress and with anxiety and depression. In an effort to identify novel molecular mechanisms that underlie vulnerability or resilience to stress, we used nonbiased analyses of microRNAs in the ventral hippocampus (vHPC) to identify those miRNAs differentially expressed in active (long-latency (LL)/resilient) or passive (short-latency (SL)/vulnerable) rats following chronic social defeat...
June 27, 2017: Translational Psychiatry
https://www.readbyqxmd.com/read/28647289/dysregulation-of-mir-499-mir-708-and-mir-1908-during-a-depression-episode-in-bipolar-disorders
#8
Ewa Banach, Monika Dmitrzak-Weglarz, Joanna Pawlak, Pawel Kapelski, Aleksandra Szczepankiewicz, Aleksandra Rajewska-Rager, Agnieszka Slopien, Maria Skibinska, Piotr Czerski, Joanna Hauser
Affective disorders include unipolar disorder (UP) (depression episodes) and bipolar disorder (BP) (depression and mania episodes). Currently, no biological markers are known that can help to differentiate these disorders. However, recent studies have suggested that psychiatric disorders can be connected with small, non-coding RNA, like microRNA. The objective of this study was to analyse the expression level of three microRNAs (miR-499, miR-708, miR-1908) in bipolar and unipolar disorder during depression episodes and after entering the remission state...
June 21, 2017: Neuroscience Letters
https://www.readbyqxmd.com/read/28634203/papers-of-note-in-science356-6343
#9
Annalisa M VanHook
This week's articles describe a mechanism by which starvation primes a cellular nutrient-sensing system for activation upon refeeding; microRNAs that control pain sensitivity; and the lasting effects of early life stress on the likelihood of developing depression.
June 20, 2017: Science Signaling
https://www.readbyqxmd.com/read/28631567/microrna-1285-5p-influences-the-proliferation-and-metastasis-of-non-small-cell-lung-carcinoma-cells-via-downregulating-cdh1-and-smad4
#10
Shixia Zhou, Zhongmian Zhang, Pengyuan Zheng, Wenchao Zhao, Na Han
Abnormal expression of microRNAs has been reported to regulate gene expression and cancer cell growth, invasion, and migration. Recently, upregulation of hsa-miR-1285 was demonstrated in bronchoalveolar lavage fluid samples from patients with lung cancer and downregulation in plasma level of stage-I lung cancer patients. However, the function and the underlying mechanism of miR-1285 in non-small-cell lung carcinoma have not been elucidated. In this study, we found that miR-1285-5p, the mature form of miR-1285, was significantly upregulated in human non-small-cell lung carcinoma cell lines A549 and SK-MES-1...
June 2017: Tumour Biology: the Journal of the International Society for Oncodevelopmental Biology and Medicine
https://www.readbyqxmd.com/read/28627674/mir-200c-serves-an-important-role-in-h5v-endothelial-cells-in-high-glucose-by-targeting-notch1
#11
Yunfeng Zhang, Qiang Guan, Xing Jin
Diabetic vasculopathy is the leading cause of impairment and death in diabetic patients, a variety of factors are involved in its underlying pathological process, however, endothelial cell (EC) dysfunction serves a significant role in the process. MicroRNAs (miRNAs) have emerged as potential therapeutic candidates, due to their ability to regulate multiple targets involved in ECs. The aim of the present study was to investigate the role of miR‑200c in regulating ECs in high glucose condition. To investigate the role of miR‑200c in regulating hyperglycemia induced ECs by targeting Notch1, ECs H5V cells were cultured in high sugar conditions to initiate the inhibition of Notch1, the same cells in normal medium as the control...
August 2017: Molecular Medicine Reports
https://www.readbyqxmd.com/read/28618313/a-mir4646-associated-methylation-locus-is-hypomethylated-in-adolescent-depression
#12
Adrian E Boström, Diana-Maria Ciuculete, Misty Attwood, Regina Krattinger, Lamia Nikontovic, Olga E Titova, Gerd A Kullak-Ublick, Jessica Mwinyi, Helgi B Schiöth
BACKGROUND: Studies of epigenetics and transcriptional activity in adolescents may provide knowledge about possible preventive strategies of depression. METHODS: We present a methylome-wide association study (MWAS) and cohort validation analysis of depression in adolescents, in two separate cohorts: discovery (n=93) and validation data set 1 (n=78). The genome-wide methylation pattern was measured from whole blood using the Illumina 450K array. A second validation cohort, validation data set 2, consists of post-mortem brain biopsies from depressed adults (n=58)...
October 1, 2017: Journal of Affective Disorders
https://www.readbyqxmd.com/read/28549965/microrna-101-in-the-ventrolateral-orbital-cortex-vlo-modulates-depressive-like-behaviors-in-rats-and-targets-dual-specificity-phosphatase-1-dusp1
#13
Yan Zhao, Shuang Wang, Zheng Chu, Yonghui Dang, Juanxia Zhu, Xingli Su
Long-term exposure to stress plays a key role in the pathogenesis of major depression. Recently, the ventrolateral orbital cortex (VLO) has received considerable attention for its role in the antidepressant response. However, the mechanisms underlying stress response in the VLO remain largely elusive. MiR-101 has been implicated in regulating multiple neurological processes. The present study used the chronic unpredictable mild stress (CUMS) rat model to investigate the expression of miR-101 in the VLOs of rat brains and the possible relevance of miR-101 to depression...
May 23, 2017: Brain Research
https://www.readbyqxmd.com/read/28530238/micrornas-146a-b-5-and-425-3p-and-24-3p-are-markers-of-antidepressant-response-and-regulate-mapk-wnt-system-genes
#14
Juan Pablo Lopez, Laura M Fiori, Cristiana Cruceanu, Rixing Lin, Benoit Labonte, Hannah M Cates, Elizabeth A Heller, Vincent Vialou, Stacy M Ku, Christophe Gerald, Ming-Hu Han, Jane Foster, Benicio N Frey, Claudio N Soares, Daniel J Müller, Faranak Farzan, Francesco Leri, Glenda M MacQueen, Harriet Feilotter, Kathrin Tyryshkin, Kenneth R Evans, Peter Giacobbe, Pierre Blier, Raymond W Lam, Roumen Milev, Sagar V Parikh, Susan Rotzinger, Steven C Strother, Cathryn M Lewis, Katherine J Aitchison, Gayle M Wittenberg, Naguib Mechawar, Eric J Nestler, Rudolf Uher, Sidney H Kennedy, Gustavo Turecki
Antidepressants (ADs) are the most common treatment for major depressive disorder (MDD). However, only ∼30% of patients experience adequate response after a single AD trial, and this variability remains poorly understood. Here, we investigated microRNAs (miRNAs) as biomarkers of AD response using small RNA-sequencing in paired samples from MDD patients enrolled in a large, randomized placebo-controlled trial of duloxetine collected before and 8 weeks after treatment. Our results revealed differential expression of miR-146a-5p, miR-146b-5p, miR-425-3p and miR-24-3p according to treatment response...
May 22, 2017: Nature Communications
https://www.readbyqxmd.com/read/28521412/microrna-335-and-its-target-rock1-synergistically-influence-tumor-progression-and-prognosis-in-osteosarcoma
#15
Yong Wang, Ningning Wang, Xiandong Zeng, Jie Sun, Guangbin Wang, Huimian Xu, Wei Zhao
MicroRNA (miR)-335 and Rho-associated serine-threonine protein kinase 1 (Rock1) is ectopically expressed in multiple malignant tumors including osteosarcoma. The present study aimed to clarify whether the combined ectopically expressed miR-335 and Rock1 was correlated with clinicopathological features and prognosis in patients with osteosarcoma. The expression of miR-335 and Rock1 in 91 osteosarcoma tissue samples and 47 noncancerous bone tissues were determined respectively by in situ hybridization and immunohistochemistry...
May 2017: Oncology Letters
https://www.readbyqxmd.com/read/28520926/investigation-of-mir-1202-mir-135a-and-mir-16-in-major-depressive-disorder-and-antidepressant-response
#16
Laura M Fiori, Juan Pablo Lopez, Stephane Richard-Devantoy, Marcelo Berlim, Eduardo Chachamovich, Fabrice Jollant, Jane Foster, Susan Rotzinger, Sidney Kennedy, Gustavo Turecki
Background: Major depressive disorder is a debilitating illness, which is most commonly treated with antidepressant drugs. As the majority of patients do not respond on their first trial, there is great interest in identifying biological factors which indicate the most appropriate treatment for each patient. Studies suggest that microRNA represent excellent biomarkers to predict antidepressant response. Methods: We investigated the expression of miR-1202, miR-135a, and miR-16 in peripheral blood from two cohorts of depressed patients who received eight weeks of antidepressant therapy...
May 16, 2017: International Journal of Neuropsychopharmacology
https://www.readbyqxmd.com/read/28490207/microrna-124-a-putative-therapeutic-target-and-biomarker-for-major-depression
#17
Yogesh Dwivedi
No abstract text is available yet for this article.
May 25, 2017: Expert Opinion on Therapeutic Targets
https://www.readbyqxmd.com/read/28471382/decrease-of-mir-195-promotes-chondrocytes-proliferation-and-maintenance-of-chondrogenic-phenotype-via-targeting-fgf-18-pathway
#18
Yong Wang, Tao Yang, Yadong Liu, Wei Zhao, Zhen Zhang, Ming Lu, Weiguo Zhang
Slow growth and rapid loss of chondrogenic phenotypes are the major problems affecting chronic cartilage lesions. The role of microRNA-195 (miR-195) and its detailed working mechanism in the fore-mentioned process remains unknown. Fibroblastic growth factor 18 (FGF-18) plays a key role in cartilage homeostasis; whether miR-195 could regulate FGF-18 and its downstream signal pathway in chondrocyte proliferation and maintenance of chondrogenic phenotypes still remains unclear. The present research shows elevated miR-195 but depressed FGF-18 expressed in joint fluid specimens of 20 patients with chronic cartilage lesions and in CH1M and CH3M chondrocytes when compared with that in joint fluid specimens without cartilage lesions and in CH1W and CH2W chondrocytes, respectively...
May 4, 2017: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/28463242/exercise-alters-mouse-sperm-small-noncoding-rnas-and-induces-a-transgenerational-modification-of-male-offspring-conditioned-fear-and-anxiety
#19
A K Short, S Yeshurun, R Powell, V M Perreau, A Fox, J H Kim, T Y Pang, A J Hannan
There is growing evidence that the preconceptual lifestyle and other environmental exposures of a father can significantly alter the physiological and behavioral phenotypes of their children. We and others have shown that paternal preconception stress, regardless of whether the stress was experienced during early-life or adulthood, results in offspring with altered anxiety and depression-related behaviors, attributed to hypothalamic-pituitary-adrenal axis dysregulation. The transgenerational response to paternal preconceptual stress is believed to be mediated by sperm-borne small noncoding RNAs, specifically microRNAs...
May 2, 2017: Translational Psychiatry
https://www.readbyqxmd.com/read/28389369/prenatal-stress-and-depression-associated-neuronal-development-in-neonates
#20
REVIEW
Mahino Fatima, Saurabh Srivastav, Amal Chandra Mondal
Prenatal maternal depression has its direct effects on early brain development deficits with permanent changes in neuroendocrine functions and impaired behavior in offsprings. Prenatal stress (PS) transmits its affect on developing fetus and on pregnancy outcomes in adult offsprings. This results in impaired neurodevelopment, delayed cognitive and motor development with impaired behavior towards stressful conditions. There are sufficient evidences in animal models suggesting depression responsive hypothalamic-pituitary-adrenal (HPA) axis and its hormonal response via cortisol, responsible for its critical effects in both the mother and offspring...
August 2017: International Journal of Developmental Neuroscience
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