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microRNA depression

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https://www.readbyqxmd.com/read/29791588/microrna-451a-microrna-34a-5p-and-microrna-221-3p-as-predictors-of-response-to-antidepressant-treatment
#1
Wei-Hong Kuang, Zai-Quan Dong, Lian-Tian Tian, Jin Li
Aberrant expression of microRNAs (miRNAs) has been shown to be involved in early observations of depression. The aim of this study was to determine if serum levels of miRNA-451a, miRNA-34a-5p, and miRNA-221-3p can serve as indicators of disease progression or therapeutic efficacy in depression. We collected data from 84 depressed patients and 78 control volunteers recruited from the medical staff at the West China Hospital. Depression severity was rated using the 24-item Hamilton Depression Scale (HAMD). Serum miRNA-451a, miRNA-34a-5p, and miRNA-221-3p levels were determined in samples from the depressed patients before and 8 weeks after antidepressant treatment as well as in samples from controls...
2018: Brazilian Journal of Medical and Biological Research, Revista Brasileira de Pesquisas Médicas e Biológicas
https://www.readbyqxmd.com/read/29790629/long-non-coding-rna-neat1-promoted-ovarian-cancer-cells-metastasis-via-regulating-of-mir-382-3p-rock1-axial
#2
Yangcheng Liu, Yong Wang, Xinming Fu, Zhi Lu
Long non-coding RNAs (lncRNAs) are extensively involved in various malignant tumors including ovarian cancer (OC). In the present study, we focused on the expression and function of nuclear enriched abundant transcript 1 (NEAT1) work on ovarian cancer cells' metastasis. We demonstrated that NEAT1 was up-regulated in OC tissue specimens and cell lines. Also, we revealed that depression of NEAT1 inhibited OC cells' metastasis and the expression of Rho associated coiled-coil containing protein kinase 1 (ROCK1) which was a metastasis-related gene...
May 23, 2018: Cancer Science
https://www.readbyqxmd.com/read/29753317/long-noncoding-rna-dancr-working-as-a-competitive-endogenous-rna-promotes-rock1-mediated-proliferation-and-metastasis-via-decoying-of-mir-335-5p-and-mir-1972-in-osteosarcoma
#3
Yong Wang, Xiandong Zeng, Ningning Wang, Wei Zhao, Xi Zhang, Songling Teng, Yueyan Zhang, Zhi Lu
BACKGROUND: Accumulating evidences indicate that non-coding RNAs (ncRNAs) including long non-coding RNAs (lncRNAs) and microRNAs (miRNAs) acting as crucial regulators in osteosarcoma (OS). Previously, we reported that Rho associated coiled-coil containing protein kinase 1 (ROCK1), a metastatic-related gene was negatively regulated by microRNA-335-5p (miR-335-5p) and work as an oncogene in osteosarcoma. Whether any long non-coding RNAs participate in the upstream of miR-335-5p/ROCK1 axial remains unclear...
May 12, 2018: Molecular Cancer
https://www.readbyqxmd.com/read/29749487/rs2910164-in-microrna%C3%A2-146a-confers-an-elevated-risk-of-depression-in-patients-with-coronary-artery-disease-by-modulating-the-expression-of-nos1
#4
Xinling Zhang, Qianqian Huo, Wei Sun, Chunxiang Zhang, Zongyin Wu, Bing Xing, Qiang Li
Depression has been well established as an independent predictor of mortality and cardiac morbidity rates in patients with coronary artery disease (CAD). Evidence has shown that single nucleotide polymorphisms located in pre‑microRNA (miRNA) or mature miRNA may modify various biological processes and affect the process of carcinogenesis, and the downregulation of neuronal nitric oxide synthase 1 (NOS1) can induce depression. It has been shown that NOS1 is the target gene of miR‑146a, and that the rs2910164 G/C polymorphism can downregulate the expression of miR‑146a...
April 26, 2018: Molecular Medicine Reports
https://www.readbyqxmd.com/read/29731825/microrna-27a-participates-in-the-pathological-process-of-depression-in-rats-by-regulating-vegfa
#5
Jian Cui, Cunqi Gong, Baorui Cao, Longfei Li
The present study aimed to determine the expression of vascular endothelial growth factor A (VEGFA) and microRNA (miRNA/miR)-27a in hippocampal tissues, and serum from a depression model of rats. In addition, the present study aimed to understand the mechanism of regulation of miR-27a in depression. A total of 40 male rats were selected, and divided into the control and depression model groups. The rats in the model group were subjected to 14 types of stimulations to model depression. By determining the body weight, syrup consumption rate and open field test score, the extent of depression in the rats was evaluated...
May 2018: Experimental and Therapeutic Medicine
https://www.readbyqxmd.com/read/29729419/potential-role-for-microrna-in-regulating-hypoxia-induced-metabolic-suppression-in-the-jumbo-squid
#6
Hanane Hadj-Moussa, Samantha M Logan, Brad A Seibel, Kenneth B Storey
At night, Humboldt squid (Dosidicus gigas) rise to the ocean's surface to feed, but come morning, they descend into the ocean's oxygen minimum zone where they can avoid predators but must deal with severe hypoxia, high pressure, and very cold water. To survive this extreme environment, squid use various adaptations to enter a hypometabolic state characterized by metabolic rate suppression by 35-52%, relative to normoxic conditions. The molecular mechanisms facilitating this metabolic flexibility have yet to be elucidated in hypometabolic squid...
May 2, 2018: Biochimica et Biophysica Acta
https://www.readbyqxmd.com/read/29675290/diagnostic-and-immunosuppressive-potential-of-elevated-mir-424-levels-in-circulating-immune-cells-of-ischemic-stroke-patients
#7
Guangwen Li, Qingfeng Ma, Rongliang Wang, Zhibin Fan, Zhen Tao, Ping Liu, Haiping Zhao, Yumin Luo
Our previous study demonstrated that microRNA-424 (miR-424) protected against experimental stroke through inhibition of microglial proliferation and activation by targeting cell cycle proteins. The purpose of this study was to further explore the clinical significance of miR-424 in peripheral immune cells of patients with acute ischemic stroke (AIS). Blood samples were collected from 40 patients within 6 hours of symptom onset and 27 control subjects. MiR-424 levels in lymphocytes, neutrophils and plasma were determined by quantitative realtime-PCR...
April 2018: Aging and Disease
https://www.readbyqxmd.com/read/29565484/effects-of-mir-155-on-proliferation-and-apoptosis-by-regulating-foxo3a-bim-in-liver-cancer-cell-line-hcclm3
#8
W-W Liao, C Zhang, F-R Liu, W-J Wang
OBJECTIVE: MiR-155 has been shown to be up-regulated in hepatocellular carcinoma (HCC) patients. B-cell lymphoma-2 (Bcl-2) interacting mediator of cell death (BIM) regulates cell proliferation and apoptosis, as its down-regulation is involved in HCC onset. Transcriptional factor FoxO3a mediates BIM expression and is related to HCC pathogenesis. Bioinformatics analysis showed targeted regulation of FoxO3a by miR-155. This study aims to investigate whether miR-155 plays a role in mediating FoxO3a/BIM signal pathway and HCC occurrence...
March 2018: European Review for Medical and Pharmacological Sciences
https://www.readbyqxmd.com/read/29563799/analysis-of-the-association-of-mir124-1-and-its-target-gene-rgs4-polymorphisms-with-major-depressive-disorder-and-antidepressant-response
#9
Duan Zeng, Shen He, Shunying Yu, Guanjun Li, Changlin Ma, Yi Wen, Yifeng Shen, Yimin Yu, Huafang Li
Background: Increasing evidence has indicated that dysfunction of miR-124 and target gene regulator of G protein signaling 4 ( RGS4 ) may be involved in the etiology and treatment of major depressive disorder (MDD). However, the molecular mechanisms are not fully understood. This study aimed to investigate whether common genetic variations in these two genes are associated with MDD and therapeutic response to antidepressants in the Chinese population. Methods: Three polymorphisms including rs531564 (a functional single-nucleotide polymorphism [SNP] in MIR124-1 ), rs10759 (a microRNA-binding site SNP in RGS4 ), and rs951436 (a promoter SNP in RGS4 ) were genotyped in 225 Chinese MDD patients and 436 controls...
2018: Neuropsychiatric Disease and Treatment
https://www.readbyqxmd.com/read/29525411/can-we-increase-the-speed-and-efficacy-of-antidepressant-treatments-part-ii-glutamatergic-and-rna-interference-strategies
#10
REVIEW
F Artigas, P Celada, A Bortolozzi
In the second part we focus on two treatment strategies that may overcome the main limitations of current antidepressant drugs. First, we review the experimental and clinical evidence supporting the use of glutamatergic drugs as fast-acting antidepressants. Secondly, we review the involvement of microRNAs (miRNAs) in the pathophysiology of major depressive disorder (MDD) and the use of small RNAs (e.g.., small interfering RNAs or siRNAs) to knockdown genes in monoaminergic and non-monoaminergic neurons and induce antidepressant-like responses in experimental animals...
April 2018: European Neuropsychopharmacology: the Journal of the European College of Neuropsychopharmacology
https://www.readbyqxmd.com/read/29522177/mir-214-3p-targets-%C3%AE-catenin-to-regulate-depressive-like-behaviors-induced-by-chronic-social-defeat-stress-in-mice
#11
Zhi-Fang Deng, Hui-Ling Zheng, Jian-Guo Chen, Yi Luo, Jun-Feng Xu, Gang Zhao, Jia-Jing Lu, Hou-Hong Li, Shuang-Qi Gao, Deng-Zheng Zhang, Ling-Qiang Zhu, Yong-Hui Zhang, Fang Wang
β-Catenin has been implicated in major depressive disorder (MDD), which is associated with synaptic plasticity and dendritic arborization. MicroRNAs (miRNA) are small noncoding RNAs containing about 22 nucleotides and involved in a variety of physiological and pathophysiological process, but their roles in MDD remain largely unknown. Here, we investigated the expression and function of miRNAs in the mouse model of chronic social defeat stress (CSDS). The regulation of β-catenin by selected miRNA was validated by silico prediction, target gene luciferase reporter assay, and transfection experiment in neurons...
March 7, 2018: Cerebral Cortex
https://www.readbyqxmd.com/read/29495532/hippocampal-micrornas-respond-to-administration-of-antidepressant-fluoxetine-in-adult-mice
#12
Nan Miao, Junghee Jin, Seung-Nam Kim, Tao Sun
Current antidepressant treatments to anxiety and depression remain inadequate, burdened by a significant percentage of misuse and drug side-effects, due to unclear mechanisms of actions of antidepressants. To better understand the regulatory roles of antidepressant fluoxetine-related drug reactions, we here investigate changes of expression levels of hippocampal microRNAs (miRNAs) after administration of fluoxetine in normal adult mice. We find that 64 miRNAs showed significant changes between fluoxetine treatment and control groups by analyzing 626 mouse miRNAs...
February 27, 2018: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/29484897/mir-124-antagonizes-the-antidepressant-like-effects-of-standardized-gypenosides-in-mice
#13
Li-Tao Yi, Rong-Hao Mu, Shu-Qi Dong, Shuang-Shuang Wang, Cheng-Fu Li, Di Geng, Qing Liu
Our previous study demonstrated that gypenosides produced antidepressant-like effects in mice exposed to chronic mild stress in a brain-derived neurotrophic factor-dependent manner. However, whether other mechanisms are involved in the antidepressant-like effects of gypenosides is not clear. miR-124 is one of the most abundant microRNAs in the hippocampus, and its dysregulation is related to the pathophysiology of depression. The glucocorticoid receptor is dysfunctional in depression, and it is a direct target of miR-124...
April 2018: Journal of Psychopharmacology
https://www.readbyqxmd.com/read/29457788/scn5a-the-greatest-hits-collection
#14
David S Park, Glenn I Fishman
Heart failure (HF) has been referred to as the cardiovascular epidemic of our time. Understanding the molecular determinants of HF disease progression and mortality risk is of utmost importance. In this issue of the JCI, Zhang et al. uncover an important link between clinical HF mortality risk and a common variant that regulates SCN5A expression through microRNA-dependent (miR-dependent)mechanisms. They also demonstrate that haploinsufficiency of SCN5A is associated with increased accumulation of reactive oxygen species (ROS) in a genetically engineered murine model...
March 1, 2018: Journal of Clinical Investigation
https://www.readbyqxmd.com/read/29451210/intravenous-morphine-self-administration-alters-accumbal-microrna-profiles-in-the-mouse-brain
#15
Juhwan Kim, Heh-In Im, Changjong Moon
A significant amount of evidence indicates that microRNAs (miRNAs) play an important role in drug addiction. The nucleus accumbens (NAc) is a critical part of the brain's reward circuit and is involved in a variety of psychiatric disorders, including depression, anxiety, and drug addiction. However, few studies have examined the expression of miRNAs and their functional roles in the NAc under conditions of morphine addiction. In this study, mice were intravenously infused with morphine (0.01, 0.03, 0.3, 1 and 3 mg/kg/infusion) and showed inverted U-shaped response...
January 2018: Neural Regeneration Research
https://www.readbyqxmd.com/read/29377618/mir-339-depresses-cell-proliferation-via-directly-targeting-s-phase-kinase-associated-protein-2-mrna-in-lung-cancer
#16
Hong Ren, Yueqiao Zhang, Hongzhou Zhu
BACKGROUND: S-phase kinase-associated protein 2 (Skp2) takes great part in the development of multiple tumors. However, the post-transcriptional modulation mechanism of Skp2 remains unclear. Here, we present a new regulatory microRNA of Skp2, miR-339, which directly targets Skp2 to inhibit cell proliferation in lung cancer. METHODS: The expression of miR-339 or Skp2 in lung cancer samples was tested by real time-PCR. The correlation between miR-339 and Skp2 in lung cancer samples was analyzed by Pearson's correlation coefficient...
March 2018: Thoracic Cancer
https://www.readbyqxmd.com/read/29373661/macrophage-migration-inhibitory-factor-and-microrna-451a-in-response-to-mindfulness-based-therapy-or-treatment-as-usual-in-patients-with-depression-anxiety-or-stress-and-adjustment-disorders
#17
Xiao Wang, Kristina Sundquist, Karolina Palmér, Anna Hedelius, Ashfaque A Memon, Jan Sundquist
Background: Macrophage migration inhibitory factor (MIF) is a pro-inflammatory cytokine that has been associated with various psychiatric disorders. MicroRNA-451a (miR-451a) can directly target MIF and down-regulate its expression in cells. However, the role of MIF and miR-451a in psychiatric patients treated with psychotherapeutic interventions is unknown. In this study, our aim was to investigate levels of MIF and its regulating miR-451a in patients with depression, anxiety or stress- and adjustment disorders who underwent mindfulness-based therapy or treatment as usual (TAU)...
January 24, 2018: International Journal of Neuropsychopharmacology
https://www.readbyqxmd.com/read/29369067/evidence-establishing-a-link-between-prenatal-and-early-life-stress-and-asthma-development
#18
Maria José Rosa, Alison G Lee, Rosalind J Wright
PURPOSE OF REVIEW: The objective of this review is to provide an update on our evolving understanding of the effects of stress in pregnancy and during early development on the onset of asthma-related phenotypes across childhood, adolescence, and into early adulthood. RECENT FINDINGS: Accumulating evidence over the past 2 decades has established that prenatal and early-life psychological stress and stress correlates (e.g., maternal anxiety or depression) increase the risk for childhood respiratory disorders...
January 23, 2018: Current Opinion in Allergy and Clinical Immunology
https://www.readbyqxmd.com/read/29361849/role-of-complex-epigenetic-switching-in-tumor-necrosis-factor-%C3%AE-upregulation-in-the-prefrontal-cortex-of-suicide-subjects
#19
Qingzhong Wang, Bhaskar Roy, Gustavo Turecki, Richard C Shelton, Yogesh Dwivedi
OBJECTIVE: Proinflammatory cytokines have recently received considerable attention for their role in suicidal behavior; however, how the expression of cytokine genes is regulated is not clearly known. The authors examined underlying mechanisms of critical cytokine gene tumor necrosis factor-alpha (TNF-α) dysregulation in the brains of individuals who died by suicide. METHOD: TNF-α expression was examined in the dorsolateral prefrontal cortex of the postmortem brains of persons with and without major depressive disorder who died by suicide and of persons with major depressive disorder who died of causes other than suicide...
March 1, 2018: American Journal of Psychiatry
https://www.readbyqxmd.com/read/29321799/independent-and-combined-effects-of-environmental-factors-and-mir-126-mir-143-and-mir-145-on-the-risk-of-coronary-heart-disease
#20
Da-Cen Lin, Jia-Bing Lin, Zhou Chen, Rong Chen, Chun-Yu Wan, Shao-Wei Lin, Qi-Shuang Ruan, Huang-Yuan Li, Si-Ying Wu
Objective: To evaluate the effects of environmental factors and microRNAs (miRNAs) (miR-126, miR-143, and miR-145) on the risk of coronary heart disease (CHD). Methods: A frequency-matched case-control study (450 patients, 450 controls) was conducted from April 2014 to December 2016 in Fuzhou City, China. Environmental factors were investigated using a self-administered questionnaire, and the expression levels of miR-126, miR-143, and miR-145 were determined by quantitative real-time Polymerase Chain Reaction (PCR) in peripheral blood mononuclear cells...
November 2017: Journal of Geriatric Cardiology: JGC
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