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https://www.readbyqxmd.com/read/28734068/evolution-of-antero-posterior-patterning-of-the-limb-insights-from-the-chick
#1
REVIEW
Matthew Towers
The developing limbs of chicken embryos have served as pioneering models for understanding pattern formation for over a century. The ease with which chick wing and leg buds can be experimentally manipulated, while the embryo is still in the egg, has resulted in the discovery of important developmental organisers, and subsequently, the signals that they produce. Sonic hedgehog (Shh) is produced by mesenchyme cells of the polarizing region at the posterior margin of the limb bud and specifies positional values across the antero-posterior axis (the axis running from the thumb to the little finger)...
July 22, 2017: Genesis: the Journal of Genetics and Development
https://www.readbyqxmd.com/read/28733100/long-term-outcomes-after-distal-scaphoid-fractures-a-10-year-follow-up
#2
Martin Clementson, Niels Thomsen, Jack Besjakov, Peter Jørgsholm, Anders Björkman
PURPOSE: The aim of this study was to evaluate the functional, clinical, and radiological outcome 10 years after distal scaphoid fractures. METHODS: From a prospective epidemiological study on posttraumatic radial-sided wrist pain, we evaluated 41 cases of distal scaphoid fractures. All cases had been treated nonsurgically in a thumb spica cast. Patients were examined using radiographs, magnetic resonance imaging and computed tomography at the time of injury and with computed tomography after a median of 10 years (range, 8-11 years)...
July 18, 2017: Journal of Hand Surgery
https://www.readbyqxmd.com/read/28727696/the-thumb-sign
#3
Satvinder Singh Bakshi, Gaurav Balpande
No abstract text is available yet for this article.
July 21, 2017: New Zealand Medical Journal
https://www.readbyqxmd.com/read/28726836/engineered-cell-therapy-for-cancer-gets-thumbs-up-from-fda-advisers
#4
Heidi Ledford
No abstract text is available yet for this article.
July 12, 2017: Nature
https://www.readbyqxmd.com/read/28725501/functional-outcomes-of-24-hour-thumb-immobilization-in-healthy-volunteers-prospective-comparative-study
#5
Raghuveer C Muppavarapu, Lyubov Tsytsikova, Michael B Gottschalk, Poonam P Dalwadi, Charles Cassidy
Background  Immobilization is often needed for the treatment of wrist and hand injuries. The current best method of immobilization for several types of injuries has yet to be elucidated with little being reported on the functional differences of each type of immobilization. Purpose  The purpose of this study is to compare the functional outcome between healthy young volunteers with a 24-hour short arm cast (SAC) versus thumb spica cast (TSC) immobilization. Methods  A total of 50 healthy volunteers completed a baseline typing assessment and a Patient-Reported Outcomes Measurement Information System (PROMIS) upper extremity functional scoring assessment...
August 2017: Journal of Wrist Surgery
https://www.readbyqxmd.com/read/28725499/the-effect-of-metacarpophalangeal-joint-hyperextension-on-outcomes-in-the-surgical-treatment-of-carpometacarpal-joint-arthritis
#6
David M Brogan, Rose M van Hogezand, Nikola Babovic, Brian Carlsen, Sanjeev Kakar
Purpose  In the surgical treatment of thumb carpometacarpal (CMC) joint arthritis, the effect of mild preoperative metacarpophalangeal (MCP) hyperextension on postoperative functional outcomes is unknown. We sought to examine outcomes after surgical treatment of CMC arthritis in patients with and without mild preexisting MCP deformity. Methods  A retrospective review was conducted to analyze the functional outcomes of patients treated for CMC arthritis at a single institution from March 1998 to May 2009...
August 2017: Journal of Wrist Surgery
https://www.readbyqxmd.com/read/28723187/wearable-flexible-and-stretchable-glove-biosensor-for-on-site-detection-of-organophosphorus-chemical-threats
#7
Rupesh K Mishra, Lee J Hubble, Aida Martín, Rajan Kumar, Abbas Barfidokht, Jayoung Kim, Mustafa M Musameh, Ilias L Kyratzis, Joseph Wang
A flexible glove-based electrochemical biosensor with highly stretchable printed electrode system has been developed as a wearable point-of-use screening tool for defense and food security applications. This disposable-mechanically robust "lab-on-a-glove" integrates a stretchable printable enzyme-based biosensing system and active surface for swipe sampling on different fingers, and is coupled with a compact electronic interface for electrochemical detection and real-time wireless data transmission to a smartphone device...
April 28, 2017: ACS Sensors
https://www.readbyqxmd.com/read/28720525/motor-resonance-during-action-observation-is-gaze-contingent-a-tms-study
#8
Giorgia D'Innocenzo, Claudia C Gonzalez, Alexander V Nowicky, A Mark Williams, Daniel T Bishop
When we observe others performing an action, visual input to our mirror neuron system is reflected in the facilitation of primary motor cortex (M1), a phenomenon known as 'motor resonance'. However, it is unclear whether this motor resonance is contingent upon our point-of-gaze. In order to address this issue, we collected gaze data from participants as they viewed an intransitive action - thumb abduction/adduction - under four conditions: with natural gaze behaviour (free viewing) and with their gaze fixated on each of three predetermined loci at various distances from the prime mover...
July 15, 2017: Neuropsychologia
https://www.readbyqxmd.com/read/28720008/a-cadaveric-study-of-the-thread-trigger-finger-release-the-first-annular-pulley-transection-through-thread-transecting-technique
#9
Danqing Guo, Danzhu Guo, Joseph Guo, Logan C McCool, Brionn Tonkin
BACKGROUND: After the thread transecting technique was successfully applied for the thread carpal tunnel release, we researched using the same technique in the thread trigger finger release (TTFR). This study was designed to test the operational feasibility of the TTFR on cadavers and verify the limits of division on the first annular (A1) pulley to ensure a complete trigger finger release with minimal iatrogenic injuries. METHODS: The procedure of TTFR was performed on 14 fingers and 4 thumbs of 4 unembalmed cadaveric hands...
March 1, 2017: Hand: Official Journal of the American Association for Hand Surgery
https://www.readbyqxmd.com/read/28720007/extensor-pollicis-brevis-spiral-tenodesis-for-combined-metacarpophalangeal-instability-and-trapeziometacarpal-arthritis
#10
Mark Henry
BACKGROUND: In more advanced stages of trapeziometacarpal arthritis, the thumb metacarpal may develop an adduction contracture, leading to secondary hyperextension instability of the metacarpophalangeal joint. Following trapeziometacarpal arthroplasty, uncorrected substantial metacarpophalangeal hyperextension may contribute to ongoing Z-collapse deformity, weakness of pinch and grip, and patient perception of diminished function. METHODS: We prospectively analyzed a consecutive case series of 55 trapeziometacarpal arthroplasty patients (mean age, 60 years; 7 males) who received simultaneous extensor pollicis brevis spiral tenodesis for thumb metacarpophalangeal hyperextension of at least 50°...
March 1, 2017: Hand: Official Journal of the American Association for Hand Surgery
https://www.readbyqxmd.com/read/28719976/radiographic-analysis-of-simulated-first-dorsal-interosseous-and-opponens-pollicis-loading-upon-thumb-cmc-joint-subluxation-a-cadaver-study
#11
Julie E Adams, Virginia O'Brien, Erik Magnusson, Benjamin Rosenstein, David J Nuckley
BACKGROUND: Therapy programs to treat thumb carpometacarpal (CMC) arthritis may engage selective activation and reeducation of thenar muscles, particularly the first dorsal interosseous (FDI) and opponens pollicis (OP) to reduce subluxation of the joint. We describe the effect of simulated selective activation of the FDI and OP muscles upon radiographic subluxation of the thumb CMC joint. METHODS: In a cadaver model of CMC subluxation, loads were applied to the FDI, the OP, and then concomitantly at 0%, 25%, 50%, 75%, and 100% maximal loads and radial subluxation of the joint and reduction in subluxation was measured...
February 1, 2017: Hand: Official Journal of the American Association for Hand Surgery
https://www.readbyqxmd.com/read/28719974/the-accuracy-of-common-hand-injections-with-and-without-ultrasound-an-anatomical-study
#12
Philip To, Kaylan N McClary, Micah K Sinclair, Brittany A Stout, Mohab Foad, Shannon Hiratzka, Peter J Stern
BACKGROUND: The aim of the study is to determine the accuracy of hand injections with and without the aid of ultrasound (U/S) into the carpal tunnel, thumb carpometacarpal (CMC) joint, first dorsal compartment (DC) and the radiocarpal (RC) joint. METHODS: Four participants of various level of experience injected the carpal tunnel, thumb CMC, first DC, and RC joint into 40 fresh frozen cadaver specimens with blue dye and radiographic contrast. Participants 1 and 2 were injected without U/S guidance, and participants 3 and 4 were injected with U/S guidance...
February 1, 2017: Hand: Official Journal of the American Association for Hand Surgery
https://www.readbyqxmd.com/read/28719556/inadvertent-harvest-of-the-median-nerve-instead-of-the-palmaris-longus-tendon
#13
Bruce M Leslie, A Lee Osterman, Scott W Wolfe
BACKGROUND: The palmaris longus tendon is frequently used as a tendon graft or ligament replacement. In rare instances the median nerve has been inadvertently harvested instead of the palmaris longus for use as a tendon. METHODS: Nineteen cases in which the median nerve had been mistakenly harvested instead of the palmaris longus tendon were collected from members of the American Society for Surgery of the Hand (ASSH) Listserve. Surgeons involved in the subsequent care of the subject who had had an inadvertent harvest were contacted or the chart was reviewed...
July 19, 2017: Journal of Bone and Joint Surgery. American Volume
https://www.readbyqxmd.com/read/28718310/comparison-of-computed-tomography-articular-surface-geometry-of-male-versus-female-thumb-carpometacarpal-joints
#14
Jessica G Shih, James G Mainprize, Paul A Binhammer
BACKGROUND: Given the predilection of first carpometacarpal (CMC) joint osteoarthritis in women compared with men, we aim to determine the differences in first CMC joint surface geometry and congruence between young healthy males and females. METHODS: Wrist computed tomographic (CT) scan data of 11 men and 11 women aged 20 to 35 years were imported into 3-dimensional software programs. The first metacarpal and the trapezium were aligned in a standardized position according to landmarks at key points on Gaussian and maximum curvature maps...
February 1, 2017: Hand: Official Journal of the American Association for Hand Surgery
https://www.readbyqxmd.com/read/28718309/intra-articular-fracture-of-the-base-of-the-first-metacarpal-bone-treatment-through-a-volar-approach
#15
Violeta Levy, Marcelo Mazzola, Martín Gonzalez
BACKGROUND: Management of Bennett fractures has been controversial. Early reports supported closed reduction and casting with or without percutaneous pinning. Later, open reduction and internal fixation was advocated. The purpose of this article is to assess the surgical treatment using a direct volar approach. METHODS: Between March 2008 and December 2014, 21 patients with intra-articular first metacarpal fractures displaced more than 1 mm were operated on using a direct volar approach...
January 1, 2017: Hand: Official Journal of the American Association for Hand Surgery
https://www.readbyqxmd.com/read/28714493/handwashing-practices-in-neonatal-intensive-care-unit-paediatric-intensive-care-unit-and-neonatal-nurseries-in-patan-hospital
#16
S Joshi, P Amatya, B Poudel, S A Yadav
BACKGROUND: Hand hygiene has been identified as the single most important factor in minimising hospital acquired infections. However, compliance of handwashing guidelines has remained low. The aim of this study was to study the handwashing practices in the Paediatric and Neonatal intensive care units and Neonatal nurseries in Patan Hospital, and secondly to re-evaluate the improvement on compliance of handwashing guidelines after intervention. METHODS: Pre-intervention study was conducted by covertly observing the handwashing practices by the healthcare workers...
January 2017: Journal of Nepal Health Research Council
https://www.readbyqxmd.com/read/28714331/-hand-hygiene-technique-assessment-using-electronic-equipment-in-26-hungarian-healthcare-institutions
#17
Ákos Lehotsky, Júlia Morvai, László Szilágyi, Száva Bánsághi, Alíz Benkó, Tamás Haidegger
INTRODUCTION: Hand hygiene is probably the most effective tool of nosocomial infection prevention, however, proper feedback and control is needed to develop the individual hand hygiene practice. AIM: Assessing the efficiency of modern education tools, and digital demonstration and verification equipment during their wide-range deployment. METHOD: 1269 healthcare workers took part in a training organized by our team. The training included the assessment of the participants' hand hygiene technique to identify the most often missed areas...
July 2017: Orvosi Hetilap
https://www.readbyqxmd.com/read/28711411/efficacy-of-a-radial-based-thumb-metacarpophalangeal-stabilizing-orthosis-for-protecting-the-thumb-metacarpophalangeal-joint-ulnar-collateral-ligament
#18
Joseph A Gil, Kerry Ebert, Keri Blanchard, Avi D Goodman, Joseph J Crisco, Julia A Katarincic
STUDY DESIGN: Basic research (biomechanics). INTRODUCTION: The high degree of motion that occurs at the thumb metacarpophalangeal (MCP) joint must be taken into account when immobilizing a partially torn or repaired thumb ulnar collateral ligament. PURPOSE OF THE STUDY: To determine the efficacy of a radial-based thumb MCP-stabilizing orthosis in resisting abduction across the thumb ulnar collateral ligament. METHODS: Ten fresh cadaveric hands were mounted to a custom board...
July 12, 2017: Journal of Hand Therapy: Official Journal of the American Society of Hand Therapists
https://www.readbyqxmd.com/read/28711157/ma%C3%A3-a-trapeziometacarpal-joint-arthroplasty-clinical%C3%A2-and-radiological-outcomes-of-80-patients-with%C3%A2-more-than-6-years-of-follow-up
#19
Adriano Toffoli, Jacques Teissier
PURPOSE: Trapeziometacarpal (TMC) total joint replacement is increasingly being performed in Europe. MAÏA TMC total joint arthroplasty is a modular uncemented ball-and-socket hydroxyapatite-coated implant. This study assessed the midterm clinical and radiological results of the MAÏA TMC prosthesis. METHODS: This single-center retrospective study involved 80 patients who underwent 96 MAÏA TMC prosthesis implantations from February 2006 to April 2009, and who had a minimum of 5 years' follow-up...
July 13, 2017: Journal of Hand Surgery
https://www.readbyqxmd.com/read/28710267/increased-processivity-misincorporation-and-nucleotide-incorporation-efficiency-in-sulfolobus-solfataricus-dpo4-thumb-domain-mutations
#20
Li Wang, Chenchen Liang, Jing Wu, Liming Liu, Keith E J Tyo
The present study aimed to increase the processivity of Sulfolobus solfataricus DNA polymerase Dpo4. Protein engineering and bioinformatics were used to compile a library of potential Dpo4 mutation sites. Ten potential mutants were identified and constructed. A primer extension assay was used to evaluate the processivity of Dpo4 mutants. Thumb (A181D) and finger (E63K) domain mutants showed a processivity of 20 and 19 nucleotides (nt), respectively. A little finger domain mutant (I248Y) exhibited a processivity of 17 nt, only 1 nt more than wild-type Dpo4...
July 14, 2017: Applied and Environmental Microbiology
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