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https://www.readbyqxmd.com/read/29150383/the-diagnostic-clinical-value-of-thumb-metacarpal-grind-pressure-shear-flexion-and-extension-tests-for-carpometacarpal-osteoarthritis
#1
Yaron Sela, Jodi Seftchick, William L Wang, Mark E Baratz
STUDY DESIGN: Clinical measurement. INTRODUCTION: Common provocative maneuvers to differentiate thumb carpometacarpal (CMC) osteoarthritis from other sources of pain are the grind, metacarpal (MC) flexion, and MC extension tests. A maneuver known as the pressure-shear test is described here. PURPOSE OF THE STUDY: To compare the diagnostic value of the grind, metacarpal flexion, metacarpal extension, and pressure-shear tests for CMC osteoarthritis of the thumb...
November 14, 2017: Journal of Hand Therapy: Official Journal of the American Society of Hand Therapists
https://www.readbyqxmd.com/read/29148131/temporal-and-spatial-variability-of-surface-motor-activation-zones-in-hemiplegic-patients-during-functional-electrical-stimulation-therapy-sessions
#2
Jovana Malešević, Matija Štrbac, Milica Isaković, Vladimir Kojić, Ljubica Konstantinović, Aleksandra Vidaković, Suzana Dedijer Dujović, Miloš Kostić, Thierry Keller
The goal of this study was to investigate surface motor activation zones and their temporal variability using an advanced multi-pad functional electrical stimulation system. With this system motor responses are elicited through concurrent activation of electrode matrix pads collectively termed "virtual electrodes" (VEs) with appropriate stimulation parameters. We observed VEs used to produce selective wrist, finger, and thumb extension movements in 20 therapy sessions of 12 hemiplegic stroke patients. The VEs which produce these three selective movements were created manually on the ergonomic multi-pad electrode by experienced clinicians based on visual inspection of the muscle responses...
November 2017: Artificial Organs
https://www.readbyqxmd.com/read/29146507/impact-of-osteoarthritis-and-total-joint-arthroplasty-on-the-kinematics-of-the-trapeziometacarpal-joint-a-pilot-study
#3
Priscilla D'Agostino, Benjamin Dourthe, Faes Kerkhof, Evie E Vereecke, Filip Stockmans
PURPOSE: To quantify the effect of osteoarthritis (OA) and total trapeziometacarpal (TMC) joint replacement on thumb kinematics during the primary physiological motions of the thumb. METHODS: We included 4 female patients with stage III TMC OA. A computed tomography-based markerless method was used to quantify the 3-dimensional thumb kinematics in patients before and after TMC joint replacement surgery with the Arpe implant. RESULTS: Trapeziometacarpal OA led to a marked decrease of internal rotation and abduction of the first metacarpal (MC1) during thumb flexion and a decrease of MC1 adduction during thumb adduction...
November 14, 2017: Journal of Hand Surgery
https://www.readbyqxmd.com/read/29142556/occurrence-of-oral-habits-among-preschool-children-with-autism-spectrum-disorder
#4
Fares S Al-Sehaibany
Objective: To determine occurrence of oral habits among Saudi preschool children with autism spectrum disorder (ASD) and compare it with healthy preschool children. Methods: This study was conducted over a 14-months period in Riyadh, Saudi Arabia. The sample consisted of two groups; a study group (SG) of 150 ASD children, and a control group (CG) of age- and gender-matched 150 healthy children. The parents of the children in both the groups were administered a questionnaire that included questions about the children's demographic information and previous or persistent oral habits...
September 2017: Pakistan Journal of Medical Sciences Quarterly
https://www.readbyqxmd.com/read/29138875/variant-course-of-extensor-pollicis-brevis-tendon-in-the-third-extensor-compartment
#5
Shiro Sugiura, Yusuke Matsuura, Takane Suzuki, Satoru Nishikawa, Chisato Mori, Kazuki Kuniyoshi
INTRODUCTION: According to the anatomical literature, the extensor pollicis brevis (EPB) tendon passes through the first compartment and enters the base of the proximal phalanx of the thumb. There have been a few reports on the different types of supernumerary EPB tendons; however, an unusual course of the EPB tendon is extremely rare. MATERIALS AND METHODS: During routine cadaveric dissection in the Department of Gross Anatomy, we detected an variant EPB muscle in a 96-year-old fresh female cadaver...
November 14, 2017: Surgical and Radiologic Anatomy: SRA
https://www.readbyqxmd.com/read/29137867/functionalized-2-1-benzothiazine-2-2-dioxides-as-new-inhibitors-of-dengue-ns5-rna-dependent-rna-polymerase
#6
Rolando Cannalire, Delia Tarantino, Andrea Astolfi, Maria Letizia Barreca, Stefano Sabatini, Serena Massari, Oriana Tabarrini, Mario Milani, Gilles Querat, Eloise Mastrangelo, Giuseppe Manfroni, Violetta Cecchetti
Over recent years, many RNA viruses have been "re-discovered", including life-threatening flaviviruses, such as Dengue, Zika, and several encephalitis viruses. Since no specific inhibitors are currently available to treat these infections, there is a pressing need for new therapeutics. Among the flaviviral proteins, NS5 RNA-dependent RNA polymerase (RdRp) represents a validated target being essential for viral replication and it has no human analog. To date, few NS5 RdRp inhibitor chemotypes have been reported and no inhibitors are currently in clinical development...
November 11, 2017: European Journal of Medicinal Chemistry
https://www.readbyqxmd.com/read/29137644/functional-resonance-magnetic-imaging-fmri-in-adolescents-with-idiopathic-musculoskeletal-pain-a-paradigm-of-experimental-pain
#7
Juliana Molina, Edson Amaro, Liana Guerra Sanches da Rocha, Liliana Jorge, Flavia Heloisa Santos, Claudio A Len
BACKGROUND: Studies on functional magnetic resonance imaging (fMRI) have shown that adults with musculoskeletal pain syndromes tolerate smaller amount of pressure (pain) as well as differences in brain activation patterns in areas related to pain.The objective of this study was to evaluate, through fMRI, the brain activation in adolescents with idiopathic musculoskeletal pain (IMP) while performing an experimental paradigm of pain. METHODS: The study included 10 consecutive adolescents with idiopathic musculoskeletal pain (average age 16...
November 14, 2017: Pediatric Rheumatology Online Journal
https://www.readbyqxmd.com/read/29136133/representations-of-fine-digit-movements-in-posterior-and-anterior-parietal-cortex-revealed-using-long-train-intracortical-microstimulation-in-macaque-monkeys
#8
Mary K L Baldwin, Dylan F Cooke, Adam B Goldring, Leah Krubitzer
The current investigation in macaque monkeys utilized long-train intracortical microstimulation to determine the extent of cortex from which movements could be evoked. Not only were movements evoked from motor areas (PMC and M1), but they were also evoked from posterior parietal (5, 7a, 7b) and anterior parietal areas (3b, 1, 2). Large representations of digit movements involving only the index finger (D2) and thumb (D1), were elicited from areas 1, 2, 7b, and M1. Other movements evoked from these regions were similar to ethologically relevant movements that have been described in other primates...
November 9, 2017: Cerebral Cortex
https://www.readbyqxmd.com/read/29132790/ulnar-thumb-pulp-reconstruction-using-the-anterograde-homodigital-neurovascular-island-flap
#9
REVIEW
Valeriy Shubinets, River M Elliott
The thumb ulnar pulp is a critical component of key pinch and precision manipulation. Injuries to this area should be reconstructed with robust, sensate tissue that restores bulk and contour. The existing reconstructive options, however, have substantial risks and drawbacks. We describe an anterograde homodigital neurovascular island flap that provides both sensate and durable coverage of the ulnar thumb pulp. The flap uses innervated glabrous tissue, limits donor site morbidity to the thumb and first web space, and does not require microvascular anastomoses or nerve coaptation...
November 11, 2017: Journal of Hand Surgery
https://www.readbyqxmd.com/read/29132788/arthroscopic-partial-trapeziectomy-with-soft-tissue-interposition-for-symptomatic-trapeziometacarpal-arthritis-6-month-and-5-year-minimum-follow-up
#10
Anthony L Logli, Jonathan Twu, Brian J Bear, Jonathan R Lindquist, Theodore L Schoenfeldt, Kenneth J Korcek
PURPOSE: To determine if arthroscopic partial trapeziectomy (APT) and soft tissue interposition arthroplasty is an effective treatment for symptomatic trapeziometacarpal arthritis. METHODS: We retrospectively evaluated 30 consecutive patients with symptomatic isolated trapeziometacarpal arthritis, Eaton-Littler stages II and III. Treatment consisted of an APT with soft tissue interposition utilizing an acellular dermal matrix as the interposition material. At a minimum of 6 months and 5 years after surgery, Numeric Pain Rating Scale (NPRS), Quick Disabilities of the Arm, Shoulder, and Hand (QuickDASH), grip strength, oppositional and appositional pinch strengths, arthroplasty space, and thumb range of motion (ROM) were evaluated...
November 11, 2017: Journal of Hand Surgery
https://www.readbyqxmd.com/read/29132461/-clinical-features-of-rubinstein-taybi-syndrome-and-novel-mutation-in-the-crebbp-gene-an-analysis-of-one-case
#11
Yuan Li, Shan He, Hong-Ling Zhu
The patient was a girl aged 3 years and 8 months with normal body length and body weight at birth. The girl had feeding difficulty after birth. Her height, body weight, and head circumference were below the 3rd percentile. She had intellectual disability and an unusual facies manifesting as arched shaggy eyebrows, down-slanting palpebral fissures, and broad nasal bridge, but had no a beaked nose, broad thumbs, or big toes. These clinical manifestations were basically consistent with Rubinstein-Taybi syndrome (RSTS)...
November 2017: Zhongguo Dang Dai Er Ke za Zhi, Chinese Journal of Contemporary Pediatrics
https://www.readbyqxmd.com/read/29129932/the-vaccinia-virus-dna-polymerase-structure-provides-insights-into-the-mode-of-processivity-factor-binding
#12
Nicolas Tarbouriech, Corinne Ducournau, Stephanie Hutin, Philippe J Mas, Petr Man, Eric Forest, Darren J Hart, Christophe N Peyrefitte, Wim P Burmeister, Frédéric Iseni
Vaccinia virus (VACV), the prototype member of the Poxviridae, replicates in the cytoplasm of an infected cell. The catalytic subunit of the DNA polymerase E9 binds the heterodimeric processivity factor A20/D4 to form the functional polymerase holoenzyme. Here we present the crystal structure of full-length E9 at 2.7 Å resolution that permits identification of important poxvirus-specific structural insertions. One insertion in the palm domain interacts with C-terminal residues of A20 and thus serves as the processivity factor-binding site...
November 13, 2017: Nature Communications
https://www.readbyqxmd.com/read/29129140/effects-of-helix-and-fingertip-mutations-on-the-thermostability-of-xyn11a-investigated-by-molecular-dynamics-simulations-and-enzyme-activity-assays
#13
Thana Sutthibutpong, Triwit Rattanarojpong, Pongsak Khunrae
Local conformational changes and global unfolding pathways of wildtype xyn11A recombinant and its mutated structures were studied through a series of atomistic molecular dynamics (MD) simulations, along with enzyme activity assays at three incubation temperatures to investigate the effects of mutations at three different sites to the thermostability. The first mutation was to replace an unstable negatively charged residue at a surface beta turn near the active site (D32G) by a hydrophobic residue. The second mutation was to create a disulfide bond (S100C/N147C) establishing a strong connection between an alpha helix and a distal beta hairpin associated with the thermally sensitive Thumb loop, and the third mutation add an extra hydrogen bond (A155S) to the same alpha helix...
November 13, 2017: Journal of Biomolecular Structure & Dynamics
https://www.readbyqxmd.com/read/29128312/parosteal-lipoma-as-a-rare-cause-of-peripheral-neuropathy-and-local-irritation-a-report-of-12-cases
#14
Kerem Başarir, Ercan Şahin, Mahmut Kalem, Mustafa Onur Karaca, Yusuf Yildiz, Yener Sağlik
OBJECTIVE: The aim of this study was to evaluate the clinical features and functional results of patients with parosteal lipomas. METHODS: A total of 12 patients (8 females and 4 males; mean age: 45 (10-62) years) with parosteal lipomas who were treated between April 1986 and April 2014, were included into the study. The medical records of the patients were reviewed to analyze the clinical features and functional results of the patients. RESULTS: Of the 12 lipomas, 5 were localized in the proximal arm, 4 in the forearm, 1 in the distal arm, 1 in the distal thigh and 1 in the distal tibia...
November 8, 2017: Acta Orthopaedica et Traumatologica Turcica
https://www.readbyqxmd.com/read/29127501/characterization-of-a-novel-yeast-species-metschnikowia-persimmonesis-kctc-12991bp-kiom-g15050-type-strain-isolated-from-a-medicinal-plant-korean-persimmon-calyx-diospyros-kaki-thumb
#15
Young Min Kang, Ji Eun Choi, Richard Komakech, Jeong Hwan Park, Dae Wook Kim, Kye Man Cho, Seung Mi Kang, Sang Haeng Choi, Kun Chul Song, Chung Min Ryu, Keun Chul Lee, Jung-Sook Lee
The yeast strain Metschnikowia persimmonesis Kang and Choi et al., sp. nov. [type strain KIOM_G15050 = Korean Collection for Type Cultures (KCTC) 12991BP] was isolated from the stalk of native persimmon cultivars (Diospyros kaki Thumb) obtained from different regions of South Korea and was characterized phenotypically, genetically, and physiologically. The isolate grew between 4 and 40 °C (optimum temperature: 24-28 °C), pH 3-8 (pH optimum = 6.0), and in 0-4% NaCl solution (with optimal growth in absence of NaCl)...
November 10, 2017: AMB Express
https://www.readbyqxmd.com/read/29125855/functional-classification-of-grasp-strategies-used-by-hemiplegic-patients
#16
Alicia García Álvarez, Agnès Roby-Brami, Johanna Robertson, Nicolas Roche
This study aimed to identify and qualify grasp-types used by patients with stroke and determine the clinical parameters that could explain the use of each grasp. Thirty-eight patients with chronic stroke-related hemiparesis and a range of motor and functional capacities (17 females and 21 males, aged 25-78), and 10 healthy subjects were included. Four objects were used (tissue packet, teaspoon, bottle and tennis ball). Participants were instructed to "grasp the object as if you are going to use it". Three trials were video-recorded for each object...
2017: PloS One
https://www.readbyqxmd.com/read/29122185/smartphone-form-factors-effects-of-width-and-bottom-bezel-on-touch-performance-workload-and-physical-demand
#17
Seul Chan Lee, Min Chul Cha, Hwan Hwangbo, Sookhee Mo, Yong Gu Ji
This study aimed at investigating the effect of two smartphone form factors (width and bottom bezel) on touch behaviors with one-handed interaction. User experiments on tapping tasks were conducted for four widths (67, 70, 72, and 74 mm) and five bottom bezel levels (2.5, 5, 7.5, 10, and 12.5 mm). Task performance, electromyography, and subjective workload data were collected to examine the touch behavior. The success rate and task completion time were collected as task performance measures. The NASA-TLX method was used to observe the subjective workload...
February 2018: Applied Ergonomics
https://www.readbyqxmd.com/read/29121048/anatomical-variations-of-the-deep-head-of-cruveilhier-of-the-flexor-pollicis-brevis-and-its-significance-for-the-evolution-of-the-precision-grip
#18
Samuel S Dunlap, M Ashraf Aziz, Janine M Ziermann
Cruveilhier described in 1834 the human flexor pollicis brevis (FPB), a muscle of the thenar compartment, as having a superficial and a deep head, respectively, inserted onto the radial and ulnar sesamoids of the thumb. Since then, Cruveilhier's deep head has been controversially discussed. Often this deep head is confused with Henle's "interosseous palmaris volaris" or said to be a slip of the oblique adductor pollicis. In the 1960s, Day and Napier described anatomical variations of the insertions of Cruveilhier's deep head, including its absence, and hypothesized, that the shift of the deep head's insertion from ulnar to radial facilitated "true opposability" in anthropoids...
2017: PloS One
https://www.readbyqxmd.com/read/29118199/rapid-feedback-responses-are-flexibly-coordinated-across-arm-muscles-to-support-goal-directed-reaching
#19
Jeffrey Weiler, Paul L Gribble, J Andrew Pruszynski
A transcortical pathway helps support goal-directed reaching by processing somatosensory information to produce rapid feedback responses across multiple joints and muscles. We tested whether such feedback responses can account for changes in arm configuration and for arbitrary visuomotor transformations - two manipulations that alter how muscles at the elbow and wrist need to be coordinated to achieve task success. Participants used a planar three degree-of-freedom exoskeleton robot to move a cursor to a target following a mechanical perturbation that flexed the elbow...
November 8, 2017: Journal of Neurophysiology
https://www.readbyqxmd.com/read/29117844/early-results-of-the-arpe-arthroplasty-versus-trapeziectomy-for-the-treatment-of-thumb-carpometacarpal-joint-osteoarthritis
#20
Johnathan D Craik, Simon Glasgow, James Andren, Mark Sims, Reza Mansouri, Ritesh Sharma, Najab Ellahee
BACKGROUND: Thumb carpometacarpal joint arthroplasty for osteoarthritis may hold advantages over trapeziectomy by preserving range of motion, whilst providing stability and preventing thumb shortening. METHODS: We compare functional and satisfaction outcomes scores, radiological shortening and complication rates between patients treated with trapeziectomy and those receiving the ARPE thumb CMCJ arthroplasty. RESULTS: Seventy-five trapeziectomies and one hundred and ten ARPE arthroplasties were performed over the study period...
December 2017: Journal of Hand Surgery Asian-Pacific Volume
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