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https://www.readbyqxmd.com/read/28444913/vesicle-origami-cuboid-phospholipid-vesicles-formed-by-template-free-self-assembly
#1
Frederik Neuhaus, Dennis Mueller, Radu Tanasescu, Sandor Balog, Takashi Ishikawa, Gerald Brezesinski, Andreas Zumbuehl
Phospholipid liposomes are archetypical self-assembled structures. To minimize the surface tension, the vesicles typically are spherical. Deciphering the bilayer code, the basic physical interactions between phospholipids would allow these molecules to be utilized as building blocks for novel, non-spherical structures. A 1,2-diamidophospholipid is presented that self-assembles into a cuboid structure. Owing to intermolecular hydrogen bonding, the bilayer membranes form an exceptionally tight subgel packing, leading to a maximization of flat structural elements and a minimization of any edges...
April 26, 2017: Angewandte Chemie
https://www.readbyqxmd.com/read/28444787/finger-pressure-adjustments-to-various-object-configurations-during-precision-grip-in-humans-and-monkeys
#2
Riccardo Viaro, Banty Tia, Gino Coudé, Rosario Canto, Andriy Oliynyk, Paola Salmas, Lorenzo Masia, Giulio Sandini, Luciano Fadiga
In this study we recorded the pressure exerted onto an object by the index finger and the thumb of the preferred hand of eighteen human subjects and either hand of two macaque monkeys during a precision grasping task. The to-be-grasped object was a custom-made device composed by two plates which could be variably oriented by a motorized system while keeping constant the size and thus grip dimension. The to-be-grasped plates were covered by an array of capacitive sensors to measure specific features of finger adaptation, namely pressure intensity and centroid location and displacement...
April 26, 2017: European Journal of Neuroscience
https://www.readbyqxmd.com/read/28443010/enhanced-functional-connectivity-between-the-bilateral-primary-motor-cortices-after-acupuncture-at-yanglingquan-gb34-in-right-hemispheric-subcortical-stroke-patients-a-resting-state-fmri-study
#3
Yanzhe Ning, Kuangshi Li, Caihong Fu, Yi Ren, Yong Zhang, Hongwei Liu, Fangyuan Cui, Yihuai Zou
Increasing neuroimaging researches in stroke rehabilitation had revealed the neural mechanisms of rehabilitation therapy. However, little was known about the neural mechanisms of acupuncture therapy in subcortical stroke patients. The aim of this study was to investigate the changes of functional connectivity (FC) between the bilateral primary motor cortices (M1s) after acupuncture intervention in right subcortical stroke patients. Twenty right-hemispheric subcortical stroke patients and 20 healthy subjects were recruited to undergo one functional magnetic resonance imaging (fMRI) scanning...
2017: Frontiers in Human Neuroscience
https://www.readbyqxmd.com/read/28442527/a-novel-fibrillin-1-gene-mutation-leading-to-marfan-syndrome-in-a-korean-girl
#4
Hyo-Kyoung Nam, Myung-Hyun Nam, Kee-Soo Ha, Young-Jun Rhie, Kee-Hyoung Lee
Marfan syndrome is an autosomal dominant genetic disorder caused by a connective tissue defect. A nine-year-old girl was referred to our pediatric endocrinology clinic for tall stature. Physical examination revealed a lens dislocation with strabismus, high palate, positive wrist and thumb signs, joint hypermobility, and pes planus. Transthoracic echocardiography revealed dilatation of the aortic root. She was diagnosed with Marfan syndrome based on the revised Ghent diagnostic criteria. Molecular investigation identified a heterozygous c...
March 2017: Annals of Clinical and Laboratory Science
https://www.readbyqxmd.com/read/28437364/a-technique-for-the-management-of-concomitant-scaphotrapezoid-arthritis-in-patients-with-thumb-metacarpotrapezial-arthritis-interposition-arthroplasty-with-a-capitate-suture-anchor
#5
Tibor Warganich, Alexander Y Shin
Scaphotrapezoid (ST) arthritis is a common source of pain and disability that typically presents with concomitant basilar thumb arthritis. ST arthritis is often under recognized and under diagnosed as a source of continued pain after successful basilar thumb arthroplasty. Untreated, symptomatic ST arthritis can cause failure of an otherwise successfully executed thumb carpometacarpal arthroplasty due to persistent pain, which is frustrating to the patient and surgeon. Although multiple surgical treatment options have been described for basilar thumb carpometacarpal joint arthritis, there is no gold standard for the treatment of ST arthritis...
April 21, 2017: Techniques in Hand & Upper Extremity Surgery
https://www.readbyqxmd.com/read/28435575/outpatient-percutaneous-release-of-trigger-finger-a-cost-effective-and-safe-procedure
#6
Z Marij, Q Aurangzeb, H R Rizwan, R Haroon, M H Pervaiz
INTRODUCTION: Trigger finger is a common cause of pain and disability of the hand. Percutaneous release results in earlier functional recovery and patient satisfaction. This is a rapid and cost-effective method which saves a surgical procedure and results in better functional outcome. MATERIALS AND METHODS: This is a prospective observational study conducted on fifty-two fingers and thumbs in 52 patients treated from 1st July 2014 till 31st December 2014, in the Orthopaedic Section, Department of Surgery, Aga Khan University Hospital, Karachi, Pakistan...
March 2017: Malaysian Orthopaedic Journal
https://www.readbyqxmd.com/read/28433454/a-randomized-comparison-of-three-chest-compression-techniques-and-associated-hemodynamic-effect-during-infant-cpr-a-randomized-manikin-study
#7
Jacek Smereka, Lukasz Szarpak, Antonio Rodríguez-Núñez, Jerzy R Ladny, Steve Leung, Kurt Ruetzler
INTRODUCTION: Pediatric cardiac arrest is an uncommon but critical life-threatening event requiring effective cardiopulmonary resuscitation. High-quality cardio-pulmonary resuscitation (CPR) is essential, but is poorly performed, even by highly skilled healthcare providers. The recently described two-thumb chest compression technique (nTTT) consists of the two thumbs directed at the angle of 90° to the chest while having the fingers fist-clenched. This technique might facilitate adequate chest-compression depth, chest-compression rate and rate of full chest-pressure relief...
April 14, 2017: American Journal of Emergency Medicine
https://www.readbyqxmd.com/read/28430708/the-somatosensory-evoked-potential-in-reaction-time-is-gated-and-elicited-earlier-when-the-motor-response-to-a-somatosensory-cue-is-faster
#8
Koichi Hiraoka, Chisato Kori, Kana Sato
The aim of this study was to investigate whether the somatosensory-evoked potential (SEP) is gated and elicited earlier when a motor response to a somatosensory stimulus is faster. In healthy humans, the left index finger and thumb were pinched in response to a somatosensory stimulus administered over the left median nerve. The SEP elicited by this stimulus when producing a fast motor response was compared with that when producing a slow motor response. The amplitudes of N18 and frontal P40 when producing a fast motor response were smaller than those when producing a slow motor response...
May 24, 2017: Neuroreport
https://www.readbyqxmd.com/read/28428918/the-safety-of-the-thenar-portal-an-anatomical-study-of-the-thumb-carpometacarpal-arthroscopy
#9
Yong-Wei Pan, Leung-Kim Hung
Purpose To define the localization of the distal course of the motor branches of median nerve (MBMN) and its arborization and its quantitative relationships to the thenar portal of the carpometacarpal (CMC) joint in the hope of evaluating the safety of this portal. Method In 16 embalmed cadaveric upper extremities, the localization of the course of the MBMN and its arborization were defined. In 14 fresh-frozen cadaver upper extremities, the CMC arthroscopic portals, 1-U, 1-R, and a thenar portal, were established, after which the limbs were dissected...
May 2017: Journal of Wrist Surgery
https://www.readbyqxmd.com/read/28428914/development-and-validation-of-a-disease-specific-questionnaire-for-basal-joint-arthritis
#10
Peter C Noback, Joseph M Lombardi, Mani Seetharaman, Donald H Lee, Robert J Strauch, Melvin P Rosenwasser
Background The Disabilities of the Arm, Shoulder, and Hand (DASH) questionnaire is the most commonly used instrument to assess outcomes of basal joint arthritis (BJA). However, the DASH is subject to influence by the entire upper extremity. Purpose This study aims to develop and validate a disease-specific questionnaire for BJA that would be more sensitive to changes in thumb function and pain, and correlate better with objective and subjective metrics. Patients and Methods The thumb disability examination (TDX) was developed and 80 patients presenting with BJA at one of the two hospital-based hand clinics were enrolled in the validation study...
May 2017: Journal of Wrist Surgery
https://www.readbyqxmd.com/read/28425053/what-demographic-and-clinical-characteristics-correlate-with-expectations-with-trapeziometacarpal-arthritis
#11
Lana Kang, Joseph Nguyen, Sohaib Z Hashmi, Steve K Lee, Andrew J Weiland, Carol A Mancuso
BACKGROUND: Pretreatment variables have been shown to be associated with the fulfillment of patient expectations, yet in treating thumb trapeziometacarpal osteoarthritis (OA) it remains unclear how patient expectations correlate with the effectiveness of treatment. An increased understanding of the variables that affect patient expectations enables tailored patient education and patient-provider communication. QUESTIONS/PURPOSES: (1) Is there a correlation between patient demographics and clinical characteristics, and the expectations the patients have when seeking treatment for trapeziometacarpal OA? (2) What factors are independently associated with the total expectations score and frequency of expecting "back to normal" among patients treated for trapeziometacarpal OA? METHODS: Between March 2011 and October 2013, 89 patients of all 96 eligible patients seeking treatment for trapeziometacarpal OA were approached and agreed to participate in this study...
April 19, 2017: Clinical Orthopaedics and related Research
https://www.readbyqxmd.com/read/28424755/rapid-low-cost-prototyping-of-transdermal-devices-for-personal-healthcare-monitoring
#12
Sanjiv Sharma, Anwer Saeed, Christopher Johnson, Nikolaj Gadegaard, Anthony Eg Cass
The next generation of devices for personal healthcare monitoring will comprise molecular sensors to monitor analytes of interest in the skin compartment. Transdermal devices based on microneedles offer an excellent opportunity to explore the dynamics of molecular markers in the interstitial fluid, however good acceptability of these next generation devices will require several technical problems associated with current commercially available wearable sensors to be overcome. These particularly include reliability, comfort and cost...
April 2017: Sensing and Bio-Sensing Research
https://www.readbyqxmd.com/read/28423442/-atypical-lipomatous-tumour-of-the-hand
#13
Yasemin Özkan, Öznur Dervis, Matthias Woenckhaus, Ulrich Baum, Steffen Löw
Atypical lipomatous tumours (ALT) are rare semi-malignant adipose tissue tumours with the potential to transform into sarcomas. They may occur throughout the body, although the hands are very rarely involved. We present the case of a 49-year-old man with a lipomatous tumour measuring 8×4 cm at the dorsum of the right thumb. MRI demonstrated an inhomogeneous signal after contrast medium application. The tumour was excised in its entirety. Since histology confirmed the diagnosis of an ALT, the thumb was irradiated...
February 2017: Handchirurgie, Mikrochirurgie, Plastische Chirurgie
https://www.readbyqxmd.com/read/28423441/-thumb-lengthening-following-amputation-at-the-proximal-phalanx-using-a-semicircular-distraction-ring-fixator-results-of-5-cases
#14
Elvira Susanne Bodmer, Rahel Meier, Theddy Slongo, Esther Voegelin
Traumatic amputation of the thumb at the proximal phalanx or the metacarpophalangeal joint can be treated by distraction lengthening depending on the location of the amputation, the patient's age, occupation and functional demands. We report the results of proximal phalanx lengthening in 5 patients using a semicircular ring-type external fixator device. This prototype was developed at our clinic in collaboration with a specialised small company (Rotomed AG, Allmenstrasse 4, CH-4512 Bellach, www.rotomed.ch) based on the principles of Ilizarov's external fixator...
February 2017: Handchirurgie, Mikrochirurgie, Plastische Chirurgie
https://www.readbyqxmd.com/read/28420975/beta-band-corticomuscular-drive-reflects-muscle-coordination-strategies
#15
Alexander Reyes, Christopher M Laine, Jason J Kutch, Francisco J Valero-Cuevas
During force production, hand muscle activity is known to be coherent with activity in primary motor cortex, specifically in the beta-band (15-30 Hz) frequency range. It is not clear, however, if this coherence reflects the control strategy selected by the nervous system for a given task, or if it instead reflects an intrinsic property of cortico-spinal communication. Here, we measured corticomuscular and intermuscular coherence between muscles of index finger and thumb while a two-finger pinch grip of identical net force was applied to objects which were either stable (allowing synergistic activation of finger muscles) or unstable (requiring individuated finger control)...
2017: Frontiers in Computational Neuroscience
https://www.readbyqxmd.com/read/28418734/bunyaviridae-rdrps-structure-motifs-and-rna-synthesis-machinery
#16
Abdennour Amroun, Stéphane Priet, Xavier de Lamballerie, Gilles Quérat
Bunyaviridae family is the largest and most diverse family of RNA viruses. It has more than 350 members divided into five genera: Orthobunyavirus, Phlebovirus, Nairovirus, Hantavirus, and Tospovirus. They are present in the five continents, causing recurrent epidemics, epizootics, and considerable agricultural loss. The genome of bunyaviruses is divided into three segments of negative single-stranded RNA according to their relative size: L (Large), M (Medium) and S (Small) segment. Bunyaviridae RNA-dependent RNA polymerase (RdRp) is encoded by the L segment, and is in charge of the replication and transcription of the viral RNA in the cytoplasm of the infected cell...
April 18, 2017: Critical Reviews in Microbiology
https://www.readbyqxmd.com/read/28417701/survey-of-hand-surgeons-and-therapists-perceptions-of-the-benefit-of-common-surgical-procedures-of-the-hand
#17
Olli V Leppänen, Jarkko Jokihaara, Esa Jämsen, Teemu Karjalainen
OBJECTIVE: The objectives of this survey were (1) to study if surgeons' perceptions of the benefit of six surgical procedures differ if they consider themselves as patients instead of treating a patient, (2) to evaluate the role of five predetermined factors that may influence decision-making, and (3) to assess how uniformly hand surgeons and hand therapists perceive the benefits of the surgical treatments. METHODS: The members of the national societies for Hand Surgery and Hand Therapy were asked to participate in the survey...
April 18, 2017: Journal of Plastic Surgery and Hand Surgery
https://www.readbyqxmd.com/read/28417584/ir-spectroscopy-of-skin-in%C3%A2-vivo-optimal-skin-sites-and-properties-for-non-invasive-glucose-measurement-by-photoacoustic-and-photothermal-spectroscopy
#18
Alexander Bauer, Otto Hertzberg, Arne Küderle, Dominik Strobel, Miguel A Pleitez, Werner Mäntele
We have reported two methods to analyze glucose in the interstitial fluid of skin based on mid-infrared excitation with a tunable quantum cascade laser and photoacoustic or photothermal detection. These methods were evaluated for optimum skin locations to obtain reproducible glucose information. The lower part of the arm, the hypothenar, the tips of the index finger and the thumb were tested. The thumb appears to be the optimal skin location, followed by the index finger. Basic requirements for an optimum site are good capillary blood perfusion, low Stratum corneum thickness and the absence of fat layers...
April 18, 2017: Journal of Biophotonics
https://www.readbyqxmd.com/read/28417053/pacinian-corpuscle-like-structure-in-the-digital-tendon-sheath-and-nail-bed-a-study-using-late-stage-human-fetuses
#19
Ji Hyun Kim, Koichiro Sakanaka, Naomitsu Tomita, Gen Murakami, Hiroshi Abe, Shinichi Abe
Pacinian corpuscle-like structures were identified in the digital tendon sheaths and nail beds of hands obtained from eight of 12 human fetuses of gestational age 20-34 weeks (crown-rump length, 150-290 mm). The aberrant corpuscles were present in tight fibrous tissue connecting the flexor tendon sheath to the dorsal aponeurosis (138 corpuscles in the thumbs and all fingers of eight fetuses); loose fibrous tissue inside the sheath on the dorsal side of the tendon (37 corpuscles in the thumbs and all fingers of four fetuses); and the nail bed (10 clusters in the thumbs and second fingers of four smaller fetuses)...
March 2017: Anatomy & Cell Biology
https://www.readbyqxmd.com/read/28415868/-epidemiological-data-of-hungarian-skiers-and-snowboarders-medical-problems
#20
Péter Felkai, Ingrid Lengyel, Miklós Szokoly, Gábor Forgó
INTRODUCTION AND AIM: There are no high mountains or any advantageous circumstances for winter sports in Hungary, yet within the 10 million population there are about half a million people (the exact number is 550,000) who tend to go for skiing or snowboarding abroad. Authors compared the injury statistical data with results described in the international literature in order to develop conclusions about the differences in the injury patterns and frequency between the Hungarian ones' and those found in countries with plenty of winter sport possibilities...
April 2017: Orvosi Hetilap
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