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https://www.readbyqxmd.com/read/28938167/a-method-for-measuring-manual-position-control
#1
Cory Adam Potts, Alexander A Brown, Stanislaw Solnik, David A Rosenbaum
There is no generally accepted method for measuring manual position control. We developed a method for doing so. We asked university students to hold a handle that had one rotational degree of freedom. The angular position of the handle depended on the degree of pronation-supination of the forearm. The subjects' task was to hold the handle as steadily as possible to keep a needle positioned in a pie-shaped target zone on a computer screen. If the needle remained in the zone for 0.5s, the gain of the feedback loop increased; otherwise the gain decreased or remained at the starting value of 1...
September 19, 2017: Acta Psychologica
https://www.readbyqxmd.com/read/28936917/scalable-collaborative-targeted-learning-for-high-dimensional-data
#2
Cheng Ju, Susan Gruber, Samuel D Lendle, Antoine Chambaz, Jessica M Franklin, Richard Wyss, Sebastian Schneeweiss, Mark J van der Laan
Robust inference of a low-dimensional parameter in a large semi-parametric model relies on external estimators of infinite-dimensional features of the distribution of the data. Typically, only one of the latter is optimized for the sake of constructing a well-behaved estimator of the low-dimensional parameter of interest. Optimizing more than one of them for the sake of achieving a better bias-variance trade-off in the estimation of the parameter of interest is the core idea driving the general template of the collaborative targeted minimum loss-based estimation procedure...
January 1, 2017: Statistical Methods in Medical Research
https://www.readbyqxmd.com/read/28935339/quantitative-measurements-of-the-cross-sectional-configuration-of-the-flexor-pollicis-longus-tendon-using-ultrasonography-in-patients-with-pediatric-trigger-thumb
#3
Jihyeung Kim, Hyun Sik Gong, Hyun Sik Seok, Young Hun Choi, Sohee Oh, Goo Hyun Baek
PURPOSE: Pediatric trigger thumb is regarded as an acquired condition characterized by flexion deformity of the interphalangeal joint of the thumb. However, the exact etiology and pathoanatomy of this condition remain unknown. The purpose of this study was to evaluate cross-sectional configurations of the flexor pollicis longus (FPL) tendon and the area under the A1 pulley quantitatively using ultrasonography. METHODS: In this study we enrolled 43 patients, 23 boys and 20 girls, with unilateral pediatric trigger thumb...
September 19, 2017: Journal of Hand Surgery
https://www.readbyqxmd.com/read/28934868/the-auscan-and-prwhe-demonstrate-comparable-internal-consistency-and-validity-in-patients-with-early-thumb-carpometacarpal-osteoarthritis
#4
Thomas J McQuillan, Molly M Vora, Deborah E Kenney, Joseph J Crisco, Arnold-Peter C Weiss, Kerry A Ebert, Kathleen E Snelgrove, Alexandra Sarnowski, Amy L Ladd
BACKGROUND: The Australian/Canadian Osteoarthritis Hand Index (AUSCAN) and Patient-Rated Wrist-Hand Evaluation (PRWHE) are 2 patient-related outcome measures to assess pain and disability in patients with osteoarthritis (OA). The purpose of this study was to evaluate the AUSCAN and PRWHE in a large-scale, longitudinal cohort of patients with early thumb carpometacarpal (CMC) OA. METHODS: We obtained baseline data on 135 individuals (92 with early CMC OA participants and 43 asymptomatic controls) and at follow-up (year 1...
September 1, 2017: Hand: Official Journal of the American Association for Hand Surgery
https://www.readbyqxmd.com/read/28934632/in-vivo-biomechanical-behavior-of-the-trapeziometacarpal-joint-in-healthy-and-osteoarthritic-subjects
#5
Priscilla D'Agostino, Benjamin Dourthe, Faes Kerkhof, G Harry Van Lenthe, Filip Stockmans, Evie E Vereecke
BACKGROUND: The contact biomechanics of the trapeziometacarpal joint have been investigated in several studies. However, these led to conflicting results and were mostly performed in vitro. The purpose of this study was to provide further insight on the contact biomechanics of the trapeziometacarpal joint by in vivo assessment of healthy and osteoarthritic subjects. METHODS: The hands of 16 healthy women and 6 women with trapeziometacarpal osteoarthritis were scanned in positions of maximal thumb extension, flexion, abduction and adduction during three isometric tasks (lateral key pinch, power grasp and jar twist) and in thumb rest posture (relaxed neutral)...
September 12, 2017: Clinical Biomechanics
https://www.readbyqxmd.com/read/28933139/from-art-to-science-the-functional-damage-due-to-thumb-osteoarthritis-finely-described-by-velazquez-300-years-before-its-clinical-description
#6
J H Villafañe, R Cantero-Tellez, S Negrini, P Berjano
Velazquez showed to know the entity of thumb osteoarthritis by finely describing it in one of his paintings. The concepts of anatomical damage, loss of strenght, and functional impairment are transmitted to the observer.
September 21, 2017: Reumatismo
https://www.readbyqxmd.com/read/28932939/the-thumb-domain-is-not-essential-for-the-catalytic-action-of-holama-dna-polymerase
#7
Angela Gala Morena Gatius, Fabrizio Dal Piaz, Alejandro Hochkoeppler
A structural and kinetic characterization of a fragment of the HoLaMa DNA polymerase is presented here. In particular, a truncated form of HoLaMa, devoid of a consistent portion of the thumb domain, was isolated and purified. This HoLaMa fragment, denoted as ΔNter-HoLaMa, is surprisingly competent in catalyzing DNA extension, albeit featuring a kcat one order of magnitude lower than the corresponding kinetic constant of its full-length counterpart. The conformational rearrangements, if any, of enzyme tryptophanes triggered by DNA binding or extension were assayed under pre-steady-state conditions...
September 20, 2017: Protein Journal
https://www.readbyqxmd.com/read/28931614/phase-dependent-deficits-during-reach-to-grasp-after-human-spinal-cord-injury
#8
Yuming Lei, Monica A Perez
Most cervical spinal cord injuries result in asymmetrical functional impairments in hand and arm function. However, the extent to which reach-to-grasp movements are affected in humans with incomplete cervical spinal cord injury (SCI) remains poorly understood. Using kinematics and electromyographic (EMG) recordings in hand and arm muscles we studied the different phases of unilateral self-paced reach-to-grasp movements (arm acceleration, hand opening and closing) to a small cylinder in the more and less affected arms of individuals with cervical SCI and age-matched controls...
September 20, 2017: Journal of Neurophysiology
https://www.readbyqxmd.com/read/28929214/-obituary-for-professor-dr-norbert-thumb
#9
EDITORIAL
W Graninger
No abstract text is available yet for this article.
September 19, 2017: Zeitschrift Für Rheumatologie
https://www.readbyqxmd.com/read/28922325/metacarpal-like-hand-classification-and-treatment-guidelines-for-microsurgical-reconstruction-with-toe-transplantation
#10
Fu-Chan Wei, Nidal F Al Deek, Yu-Te Lin, Chung-Chen Hsu, Cheng-Hung Lin
The metacarpal-like hand is a severe hand injury, never addressed before. It describes a hand that lost a significant degree of prehension through a wide array of amputations, involving all digits proximal to the functional length except in one finger or in two digits, including the thumb.Thumb condition can be used to differentiate between two types.In type I, the thumb is intact or amputated at/or distal to the interphalangeal joint (functional length); and therefore, the reconstruction is focused on fingers mainly...
September 14, 2017: Plastic and Reconstructive Surgery
https://www.readbyqxmd.com/read/28920544/identification-of-the-location-of-the-a1-pulley-combining-palpation-technique-with-palm-landmarks-and-percutaneous-release-of-a1-pulley-with-a-19-gauge-needle-a-cadaveric-study
#11
Aleksandr Grinčuk, Karolis Baužys, Narūnas Porvaneckas, Valentinas Uvarovas, Gediminas Rauba, Sigitas Ryliškis
The aims of this study were to identify the location of the A1 pulley combining palpation technique with superficial palm landmarks and to determine the efficacy and safety of A1 pulley percutaneous release with a 19-gauge needle. Fourteen fresh frozen cadaveric specimens were used: 56 fingers and 14 thumbs. The location of the A1 pulley was based on anatomical landmarks and was identified in all digits. Complete release of the A1 pulley occurred in 60 of the 70 digits (85.7%). The length of the A1 pulley in thumbs was 5...
September 2017: Journal of Orthopaedic Surgery
https://www.readbyqxmd.com/read/28918660/factors-associated-with-radiographic-trapeziometacarpal-arthrosis-in-patients-not-seeking-care-for-this-condition
#12
Suzanne C Wilkens, Matthew A Tarabochia, David Ring, Neal C Chen
BACKGROUND: A common adage among hand surgeons is that the symptoms of trapeziometacarpal (TMC) arthrosis vary among patients independent of the radiographic severity. We studied factors associated with radiographic severity of TMC arthrosis, thumb pain, thumb-specific disability, pinch strength, and grip strength in patients not seeking care for TMC arthrosis. Our primary null hypothesis was that there are no factors independently associated with radiographic severity of TMC arthrosis according to the Eaton classification among patients not seeking care for TMC arthrosis...
September 1, 2017: Hand: Official Journal of the American Association for Hand Surgery
https://www.readbyqxmd.com/read/28917547/growth-of-the-new-thumb-metacarpal-after-pollicization-for-thumb-hypoplasia
#13
Michael A Tonkin, Nathan D Trist, Dirk J van der Spuy, Albert Yoon, Harvinder P Singh, Richard D Lawson
PURPOSE: To investigate the radiographic length and width of the new thumb metacarpal in relation to the middle finger proximal phalanx; to assess the incidence of premature physeal closure of the new metacarpal; and to consider whether there is a relationship between growth characteristics and the presence of union or nonunion of the new trapezium to the retained index finger metacarpal base. MATERIALS AND METHODS: Forty pollicizations were assessed with preoperative or immediate postoperative radiographs and follow-up radiographs to establish the growth characteristics of the new thumb metacarpal...
September 14, 2017: Journal of Hand Surgery
https://www.readbyqxmd.com/read/28913596/-perioperative-management-of-immunosuppressive-treatment-in-patients-undergoing-joint-surgery
#14
K Krüger
The perioperative management of patients on immunosuppressive drugs is uncertain due to a lack of controlled studies. Continuation of medication without a pause may increase the risk of postoperative infections and wound healing disorders and when the pause is too long this can induce a flare of the underlying rheumatic disease. Additional factors, such as rheumatic disease activity, comorbidities, previous infections and the type of surgical procedure also modulate the risk. The highest risk of infection is associated with corticosteroids depending on the dose, so that a dosage as low as possible but stable in the perioperative period is recommended...
September 14, 2017: Zeitschrift Für Rheumatologie
https://www.readbyqxmd.com/read/28912275/nmr-reveals-the-intrinsically-disordered-domain-2-of-ns5a-protein-as-an-allosteric-regulator-of-the-hepatitis-c-virus-rna-polymerase-ns5b
#15
Luiza M Bessa, Hélène Launay, Marie Dujardin, François-Xavier Cantrelle, Guy Lippens, Isabelle Landrieu, Robert Schneider, Xavier Hanoulle
Non-structural protein 5B (NS5B) is the RNAdependent RNA polymerase that catalyses replication of the hepatitis C virus (HCV) RNA genome, and so is central for its life cycle. NS5B interacts with the intrinsically disordered domain 2 of NS5A (NS5A-D2), another essential multifunctional HCV protein that is required for RNA replication. As a result, these two proteins represent important targets for anti-HCV chemotherapies. Despite this importance and the existence of NS5B crystal structures, our understanding of the conformational and dynamic behaviour of NS5B in solution and its relationship with NS5A-D2 remain incomplete...
September 14, 2017: Journal of Biological Chemistry
https://www.readbyqxmd.com/read/28906587/vascularized-thumb-metacarpal-periosteal-pedicled-flap-for-scaphoid-nonunion-an-anatomical-study-and-pediatric-case-report
#16
Sergi Barrera-Ochoa, Gerardo Mendez-Sanchez, Alfonso Rodriguez-Baeza, Jorge Knörr, Jayme Augusto Bertelli, Francisco Soldado
PURPOSE: Through an anatomical review, the primary aim of this study was to delineate the dorsal thumb metacarpal (TM) periosteal branches of the radial artery (RA). In addition, we report here the clinical utility of a vascularized TM periosteal pedicled flap (VTMPF), supplied by the first dorsal metacarpal artery (FDMA), in a complex case of scaphoid nonunion. METHODS: Ten latex-colored upper limbs from fresh human cadavers were used. Branches of the RA were dissected under 3x loupe magnification, noting the periosteal branches arising from the FDMA...
September 14, 2017: Microsurgery
https://www.readbyqxmd.com/read/28906300/isolated-dorsoradial-capsular-tear-of-the-thumb-metacarpophalangeal-joint-missed-diagnosis-and-the-management-of-delayed-presentation
#17
Yvette Godwin, Britt Ter Horst, Godwin Scerri
Isolated dorsoradial capsule injuries of the thumb metacarpophalangeal joint are different from those associated with collateral ligament disruption. Early suspicion of this rare injury is important because, if overlooked, ulnarward subluxation of extensor pollicis longus tendon can develop. Functionally, active thumb extension becomes impaired, and over the long term, a thumb Boutonniere's deformity becomes established. Joint hypermobility/instability may predispose to this injury. The 2 cases presented illustrate this through anatomic differences...
September 12, 2017: Annals of Plastic Surgery
https://www.readbyqxmd.com/read/28906289/update-on-the-therapeutic-efficacy-of-tregs-in-ibd-thumbs-up-or-thumbs-down
#18
Massimo C Fantini, Giovanni Monteleone
Crohn's disease and ulcerative colitis, the 2 major forms of inflammatory bowel disease (IBD) in humans, arise in genetically predisposed individuals because of an abnormal immune response direct against constituents of the gut flora. Defects in counter-regulatory mechanisms are supposed to amplify and maintain the IBD-associated mucosal inflammation. Therefore, restoring the balance between inflammatory and anti-inflammatory pathways in the gut could contribute to halt the IBD-associated tissue-damaging immune response...
October 2017: Inflammatory Bowel Diseases
https://www.readbyqxmd.com/read/28906142/educational-quality-of-youtube-videos-in-thumb-exercises-for-carpometacarpal-osteoarthritis-a-search-on-current-practice
#19
Jorge Hugo Villafañe, Raquel Cantero-Tellez, Kristin Valdes, Federico Giuseppe Usuelli, Pedro Berjano
BACKGROUND: Conservative treatments are commonly performed therapeutic interventions for the management of carpometacarpal (CMC) joint osteoarthritis (OA). Physical and occupational therapies are starting to use video-based online content as both a patient teaching tool and a source for treatment techniques. YouTube is a popular video-sharing website that can be accessed easily. The purpose of this study was to analyze the quality of content and potential sources of bias in videos available on YouTube pertaining to thumb exercises for CMC OA...
September 1, 2017: Hand: Official Journal of the American Association for Hand Surgery
https://www.readbyqxmd.com/read/28902605/trigger-finger-location-and-association-of-comorbidities
#20
Aadit Shah, Michael Rettig
Trigger finger is a common cause of hand pain in the adult population. Studies in the past have suggested that ring finger and thumb are the most prevalent trigger fingers. Risk factors, such as diabetes and hypothyroidism, have been reportedly linked to trigger fingers. This observational prospective study was carried out to identify the most commonly affected trigger finger and observe associated comorbidities. At a single clinical site, a total of 46 patients with 54 trigger fingers on 49 hands were identified over a 7-week period...
May 2017: Bulletin of the Hospital for Joint Diseases
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