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https://www.readbyqxmd.com/read/28634624/population-averaged-macaque-brain-atlas-with-high-resolution-ex-vivo-dti-integrated-into-in-vivo-space
#1
Lei Feng, Tina Jeon, Qiaowen Yu, Minhui Ouyang, Qinmu Peng, Virendra Mishra, Mihovil Pletikos, Nenad Sestan, Michael I Miller, Susumu Mori, Steven Hsiao, Shuwei Liu, Hao Huang
Animal models of the rhesus macaque (Macaca mulatta), the most widely used nonhuman primate, have been irreplaceable in neurobiological studies. However, a population-averaged macaque brain diffusion tensor imaging (DTI) atlas, including comprehensive gray and white matter labeling as well as bony and facial landmarks guiding invasive experimental procedures, is not available. The macaque white matter tract pathways and microstructures have been rarely recorded. Here, we established a population-averaged macaque brain atlas with high-resolution ex vivo DTI integrated into in vivo space incorporating bony and facial landmarks, and delineated microstructures and three-dimensional pathways of major white matter tracts in vivo MRI/DTI and ex vivo (postmortem) DTI of ten rhesus macaque brains were acquired...
June 20, 2017: Brain Structure & Function
https://www.readbyqxmd.com/read/28634512/diffusion-weighted-imaging-for-the-detection-and-evaluation-of-cholesteatoma
#2
REVIEW
Benjamin Henninger, Christian Kremser
Cholesteatoma is a collection of keratinous debris and stratified squamous epithelium. It is trapped in the middle ear and can lead to bony erosion. The disease is treated surgically often followed by a second-look procedure to check for residual tissue or recurrence. Cholesteatoma has specific signal-intensity characteristics on magnetic resonance imaging with very high signal intensity on diffusion weighted imaging (DWI). Various DWI techniques exist: Echo-planar imaging (EPI)-based and non-EPI-based techniques as well as new approaches like multi-shot EPI DWI...
May 28, 2017: World Journal of Radiology
https://www.readbyqxmd.com/read/28634318/evaluation-and-validation-of-the-diagnostic-value-of-the-apparent-diffusion-coefficient-for-differentiating-early-stage-endometrial-carcinomas-from-benign-mimickers-at-3t-mri
#3
Xue Wang, Yu Zhao, Yumin Hu, Yongjin Zhou, Xinjian Ye, Kun Liu, Guanghui Bai, Anna Guo, Meimei Du, Lezhen Jiang, Jinhong Wang, Zhihan Yan
Previous researchers obtained various apparent diffusion coefficient (ADC) cutoff values to differentiate endometrial carcinoma from benign mimickers with 1.5T magnetic resonance imaging (MRI). Few studies have used 3T MRI or validated the effectiveness of these cutoff ADC values prospectively. This study was designed in two stages to obtain a cutoff ADC value at 3T MRI and to validate prospectively the role of the ADC value. First, we conducted a retrospective study of 60 patients to evaluate the diagnostic value of ADC by obtain a theoretical cutoff ADC value for differentiating between benign and malignant endometrial lesions...
June 16, 2017: Oncotarget
https://www.readbyqxmd.com/read/28634311/-bevacizumab-related-hyperintense-lesions-on-diffusion-weighted-imaging-at-different-locations-in-a-patient-with-malignant-glioma
#4
Shinya Oshiro, Naoki Wakuta, Shinichi Kawai, Koichi Miki, Yutaka Shigemori
We report the case of a 60-year-old man who first presented with transient difficulty of word recall. Subsequent MRI revealed an invasive brain tumor in the left frontal lobe. The patient underwent open biopsy, and diffuse astrocytoma(WHO grade II)was diagnosed. However, the malignant potential of this tumor was not particularly low because of a few enhancement on preoperative evaluation, and radiation therapy was initially performed. Four months after ending irradiation, temozolomide treatment was introduced for tumor regrowth...
June 2017: No Shinkei Geka. Neurological Surgery
https://www.readbyqxmd.com/read/28634047/the-study-of-the-intervertebral-disc-microstructure-in-matured-rats-with-diffusion-kurtosis-imaging
#5
Li Li, Wenzhen Zhu, Weiwei Chen, Jicheng Fang, Jing Li
OBJECTIVES: The aim of this study was to use DKI to detect the microstructural change of the discs in matured normal rats. METHODS: Total 24 normal SD rats (12 males/12 females) underwent DWI/DKI and T2 sequences with a 3T MRI scanner to get the values of ADC, FA, MD, Da, Dr, MK, Ka and Kr. The discs were categorized using a five-grade degeneration grading system in the T2-images. The height of the discs and the parameters in DWI/DKI were measured to compare between the different grades and sexes...
June 17, 2017: Magnetic Resonance Imaging
https://www.readbyqxmd.com/read/28633499/lateralized-basal-ganglia-vulnerability-to-pesticide-exposure-in-asymptomatic-agricultural-workers
#6
Mechelle M Lewis, Nicholas W Sterling, Guangwei Du, Eun-Young Lee, Grace Shyu, Michael Goldenberg, Thomas Allen, Christy Stetter, Lan Kong, Shedra Amy Snipes, Byron C Jones, Honglei Chen, Richard B Mailman, Xuemei Huang
Background: Pesticide exposure is linked to Parkinson's disease (PD), a neurodegenerative disorder marked by dopamine cell loss in the substantia nigra of the basal ganglia (BG) that often presents asymmetrically. We previously reported that pesticide-exposed agricultural workers (AW) have nigral diffusion tensor (DTI) changes. The current study sought to confirm this finding, and explore its hemisphere and regional specificity within BG structures using an independent sample population...
June 19, 2017: Toxicological Sciences: An Official Journal of the Society of Toxicology
https://www.readbyqxmd.com/read/28633107/effects-of-chemical-and-physical-enhancement-techniques-on-transdermal-delivery-of-3-fluoroamphetamine-hydrochloride
#7
Ashana Puri, Kevin S Murnane, Bruce E Blough, Ajay K Banga
The present study investigated the passive transdermal delivery of 3-fluoroamphetamine hydrochloride (PAL-353) and evaluated the effects of chemical and physical enhancement techniques on its permeation through human skin. In vitro drug permeation studies through dermatomed human skin were performed using Franz diffusion cells. Passive permeation of PAL-353 from propylene glycol and phosphate buffered saline as vehicles was studied. Effect of oleic acid, maltose microneedles, ablative laser, and anodal iontophoresis on its transdermal permeation was investigated...
June 17, 2017: International Journal of Pharmaceutics
https://www.readbyqxmd.com/read/28632960/snap-tag-based-subcellular-proteins-labeling-and-fluorescent-imaging-with-naphthalimides
#8
Chao Wang, Xinbo Song, Yi Xiao
Genetically encoded technologies provide methods for specific labeling and imaging of proteins, which is essential for the understanding of their subcellular localization and function. Herein, we employ naphthalimide, an efficient two-photon fluorophore, to develop O6-benzylguanine (BG) derivatives for specific labeling of subcellular proteins and fluorescent imaging through the SNAP-tag. The three naphthalimide-BG derivatives, TNI-BG, QNI-BG and ONI-BG are conveniently synthesized through modular "click chemistry" with high yields...
June 20, 2017: Chembiochem: a European Journal of Chemical Biology
https://www.readbyqxmd.com/read/28632786/diagnostic-accuracy-of-magnetic-resonance-computed-tomography-and-contrast-enhanced-ultrasound-in-radiological-multimodality-assessment-of-peribiliary-liver-metastases
#9
Vincenza Granata, Roberta Fusco, Orlando Catalano, Antonio Avallone, Raffaele Palaia, Gerardo Botti, Fabiana Tatangelo, Francesco Granata, Marco Cascella, Francesco Izzo, Antonella Petrillo
PURPOSE: We compared diagnostic performance of Magnetic Resonance (MR), Computed Tomography (CT) and Ultrasound (US) with (CEUS) and without contrast medium to identify peribiliary metastasis. METHODS: We identified 35 subjects with histological proven peribiliary metastases who underwent CEUS, CT and MR study. Four radiologists evaluated the presence of peribiliary lesions, using a 4-point confidence scale. Echogenicity, density and T1-Weigthed (T1-W), T2-W and Diffusion Weighted Imaging (DWI) signal intensity as well as the enhancement pattern during contrast studies on CEUS, CT and MR so as hepatobiliary-phase on MRI was assessed...
2017: PloS One
https://www.readbyqxmd.com/read/28631996/role-of-diffusion-weighted-imaging-in-skull-base-lesions-a-pictorial-review
#10
Neetu Soni, Nishant Gupta, Yogesh Kumar, Manisha Mangla, Rajiv Mangla
Skull base lesions can be related to wide number of pathologies including infections, benign and malignant tumors. Accurate diagnosis and differentiation between these entities is important for prompt and appropriate treatment. However, computed tomography and routine magnetic resonance imaging techniques only provide information on the extent of the lesions, with limited ability to differentiate between benign and malignant lesions. Diffusion-weighted imaging can help in many such situations by providing additional information, including help in differentiating benign from malignant lesions, so that appropriate treatment can be initiated...
January 1, 2017: Neuroradiology Journal
https://www.readbyqxmd.com/read/28631961/intracranial-dural-chondroma-in-a-child-conventional-and-advanced-neuroimaging-characteristics-and-differential-diagnosis
#11
Shai Shrot, Alan R Cohen, Fausto J Rodriguez, Frank Berkowitz, Bruno P Soares, Thierry Agm Huisman
Intracranial chondromas are rare tumors, especially in the pediatric population. We describe the conventional and advanced neuroimaging characteristics of this rare convexity dura-based chondroma in a young adolescent. In particular we demonstrate that diffusion-weighted imaging (DWI) facilitates differentiation between a dura-based chondroma and the more frequent classical meningioma. Chondromas are typically DWI hypointense with high apparent diffusion coefficient (ADC) values while meningiomas are typically DWI hyperintense with low ADC values...
January 1, 2017: Neuroradiology Journal
https://www.readbyqxmd.com/read/28631949/diffusion-tensor-imaging-tensor-shape-analysis-for-assessment-of-regional-white-matter-differences
#12
Dana M Middleton, Jonathan Y Li, Hui J Lee, Steven Chen, Patricia I Dickson, N Matthew Ellinwood, Leonard E White, James M Provenzale
Purpose The purpose of this study was to investigate a novel tensor shape plot analysis technique of diffusion tensor imaging data as a means to assess microstructural differences in brain tissue. We hypothesized that this technique could distinguish white matter regions with different microstructural compositions. Methods Three normal canines were euthanized at seven weeks old. Their brains were imaged using identical diffusion tensor imaging protocols on a 7T small-animal magnetic resonance imaging system...
January 1, 2017: Neuroradiology Journal
https://www.readbyqxmd.com/read/28631645/primary-leptomeningeal-primitive-neuroectodermal-tumor-a-difficult-entity-to-diagnose
#13
Jyothy Sehgal, Murthy Murali Krishna Jagarlapudi, Murthy V R K Tenneti, Syed Ameer Basha, Sundaram Challa
A 25-year-old male presented with difficulty in walking, loss of vision, and seizures. A clinical possibility of craniospinal meningeal pathology was considered. On computed tomography (CT) scan and magnetic resonance imaging, there was an enhancement of leptomeninges with few ring-enhancing lesions in both frontal lobes and right frontoparietal region. He was evaluated for low backache and occipital headache 2½ years earlier and was found to have communicating hydrocephalus on CT scan. He underwent ventriculoperitoneal shunt and was followed up with CT scans...
April 2017: Indian Journal of Pathology & Microbiology
https://www.readbyqxmd.com/read/28631276/comparison-of-two-different-analysis-approaches-for-dti-free-water-corrected-and-uncorrected-maps-in-the-study-of-white-matter-microstructural-integrity-in-individuals-with-depression
#14
Maurizio Bergamino, Rayus Kuplicki, Teresa V Victor, Yoon-Hee Cha, Martin P Paulus
Diffusion tensor imaging (DTI) has often been used to examine white matter (WM) tract abnormalities in depressed subjects, but these studies have yielded inconsistent results, probably, due to gender composition or small sample size. In this study, we applied different analysis pipelines to a relatively large sample of individuals with depression to determine whether previous findings in depression can be replicated with these pipelines. We used a "standard" DTI algorithm and maps computed through a free-water (FW) corrected DTI...
June 20, 2017: Human Brain Mapping
https://www.readbyqxmd.com/read/28631081/diffusion-weighted-imaging-versus-contrast-enhanced-mr-imaging-for-the-differentiation-of-renal-oncocytomas-and-chromophobe-renal-cell-carcinomas
#15
Yan Zhong, Haiyi Wang, Yanguang Shen, Aitao Guo, Jia Wang, Suhai Kang, Lu Ma, Jingjing Pan, Huiyi Ye
OBJECTIVES: To compare the performance of diffusion-weighted imaging (DWI) with that of contrast-enhanced MRI in differentiating renal oncocytomas from chromophobe renal cell carcinomas (RCCs). METHODS: We recruited 48 patients with histopathologically confirmed renal oncocytomas (n=16) and chromophobe RCCs (n=32). All patients underwent preoperative DWI and contrast-enhanced MRI. Apparent diffusion coefficient (ADC) and signal intensity were measured in each patient...
June 19, 2017: European Radiology
https://www.readbyqxmd.com/read/28630793/bilaterally-diffuse-lacrimal-gland-involvement-initial-presentation-of-systemic-sarcoidosis
#16
Pınar Bingöl Kızıltunç, Fatma Çiftçi, Banu Hoşal, Gülşah Kaygusuz
Orbital involvement in systemic sarcoidosis is a rare condition. We report a case of orbital sarcoidosis with bilaterally huge lacrimal gland involvement as the initial manifestation of systemic sarcoidosis. A 20-year-old woman admitted the ophthalmology department with progressive bilateral upper eyelid swelling for 6 months. The only pathologic finding was the presence of bilateral, symmetrical, solid, lobular masses at the lateral upper eyelids at the location of lacrimal glands. On systemic examination, bilateral parotid and submandibular glands appeared swollen...
June 2017: Turkish Journal of Ophthalmology
https://www.readbyqxmd.com/read/28630233/motor-recovery-prediction-with-clinical-assessment-and-local-diffusion-homogeneity-after-acute-subcortical-infarction
#17
Gang Liu, Shuangquan Tan, Chao Dang, Kangqiang Peng, Chuanmiao Xie, Shihui Xing, Jinsheng Zeng
BACKGROUND AND PURPOSE: Initial clinical assessment or conventional diffusion tensor imaging parameters alone do not reliably predict poststroke recovery of motor function. Recently, local diffusion homogeneity (LDH) has been proposed to represent the local coherence of water molecule diffusion and can serve as a complementary marker for investigating white matter alterations of the brain. We aimed to determine whether a combination of initial clinical assessment and LDH could predict motor recovery after acute subcortical infarction...
June 19, 2017: Stroke; a Journal of Cerebral Circulation
https://www.readbyqxmd.com/read/28629955/correlation-study-between-dki-and-conventional-dwi-in-brain-and-head-and-neck-tumors
#18
Silvia Minosse, Simona Marzi, Francesca Piludu, Antonello Vidiri
PURPOSE: To investigate the relationship between the Diffusion Kurtosis Imaging (DKI) parameters and conventional metrics provided by Diffusion-weighted imaging (DWI) in patients affected by Brain or Head and Neck (HN) cancer. METHODS: Ten patients affected by brain tumor and nine patients with HN tumor underwent a pre-treatment MR examination at 3 T. The largest tumor section was manually contoured by two expert neuroradiologists. The apparent diffusion coefficient (Dapp) and apparent diffusional kurtosis (Kapp) parameters were determined at the voxel level by using the DKI model, and compared to the apparent diffusion coefficient (ADC) and the tissue diffusion coefficient (Dmono) obtained from mono-exponential fitting methods...
June 16, 2017: Magnetic Resonance Imaging
https://www.readbyqxmd.com/read/28629742/statistical-differences-in-the-white-matter-tracts-in-subjects-with-depression-by-using-different-skeletonized-voxel-wise-analysis-approaches-and-dti-fitting-procedures
#19
Maurizio Bergamino, Madison Farmer, Hung-Wen Yeh, Elisabeth Paul, J Paul Hamilton
Major depressive disorder (MDD) is one of the most significant contributors to the global burden of illness. Diffusion tensor imaging (DTI) is a procedure that has been used in several studies to characterize abnormalities in white matter (WM) microstructural integrity in MDD. These studies, however, have provided divergent findings, potentially due to the large variety of methodological alternatives available in conducting DTI research. In order to determine the importance of different approaches to coregistration of DTI-derived metrics to a standard space, we compared results from two different skeletonized voxel-wise analysis approaches: the standard TBBS pipeline and the Advanced Normalization Tools (ANTs) approach incorporating a symmetric image normalization (SyN) algorithm and a group-wise template (ANTs TBSS)...
June 16, 2017: Brain Research
https://www.readbyqxmd.com/read/28629605/ct-findings-in-11-patients-with-tafro-syndrome-a-variant-of-multicentric-castleman-s-disease
#20
T Kiguchi, C Sato, K Takai, Y Nakai, Y Kaneko, M Matsuki
AIM: To assess detailed computed tomography (CT) findings in patients with the recently described thrombocytopenia, anasarca, fever, reticulin fibrosis, and organomegaly (TAFRO) syndrome, in order to contribute to imaging interpretation in the challenging diagnosis of this disease. MATERIALS AND METHODS: The institutional review board approved this retrospective study and waived the need for informed consent. Eleven patients (six men, five women; mean age, 52.5 years) with confirmed TAFRO syndrome were included in this study...
June 16, 2017: Clinical Radiology
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