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https://www.readbyqxmd.com/read/29451852/delta-opioids-neuroprotective-roles-in-preclinical-studies
#1
Shahid Husain
Since ancient times, opioids have been used clinically and abused recreationally. In the early stages (about 1,000 AD) of opium history, an Arab physician, Avicenna, administered opioids to control diarrhea and eye diseases. 1 Opioids have very strong pain relieving properties and they also regulate numerous cellular responses. Opioid receptors are expressed throughout the body, including the nervous system, heart, lungs, liver, gastrointestinal tract, and retina. 2-6 Delta opioid receptors (DORs) are a very attractive target from the perspective of both receptor function and their therapeutic potential...
January 2018: Journal of Ocular Pharmacology and Therapeutics
https://www.readbyqxmd.com/read/29451446/improving-patient-safety-during-introduction-of-novel-medical-devices-through-cumulative-summation-analysis
#2
Vejay N Vakharia, Roman Rodionov, Andrew W McEvoy, Anna Miserocchi, Rachel Sparks, Aidan G O'Keeffe, Sebastien Ourselin, John S Duncan
OBJECTIVE The aim of this study was to implement cumulative summation (CUSUM) analysis as an early-warning detection and quality assurance system for preclinical testing of the iSYS1 novel robotic trajectory guidance system. METHODS Anatomically accurate 3D-printed skull phantoms were created for 3 patients who underwent implantation of 21 stereoelectroencephalography electrodes by surgeons using the current standard of care (frameless technique). Implantation schema were recreated using the iSYS1 system, and paired accuracy measures were compared with the previous frameless implantations...
February 16, 2018: Journal of Neurosurgery
https://www.readbyqxmd.com/read/29450659/social-factors-in-the-development-of-chronic-rhinosinusitis-a-systematic-review
#3
REVIEW
I Geramas, D Terzakis, E Hatzimanolis, C Georgalas
PURPOSE OF REVIEW: In an era where prevention is paramount, understanding social factors for chronic rhinosinusitis (CRS) may facilitate preventive interventions that mitigate risk factors associated with the initiation or progression of the disease. RECENT FINDINGS: Both passive and active smoking are clearly and unequivocally associated with both the incidence and the severity of rhinosinusitis, while there an increasing body of evidence linking social deprivation and low socioeconomic status with rhinosinusitis and its complications...
February 16, 2018: Current Allergy and Asthma Reports
https://www.readbyqxmd.com/read/29450499/otorhinolaryngology-and-diving-part-2-otorhinolaryngological-fitness-for-compressed-gas-scuba-diving-a-review
#4
Matt Lechner, Liam Sutton, Jonathan M Fishman, David M Kaylie, Richard E Moon, Liam Masterson, Christoph Klingmann, Martin A Birchall, Valerie J Lund, John S Rubin
Importance: Self-contained underwater breathing apparatus (scuba) diving has become increasingly popular with millions of people diving each year. Otorhinolaryngologists are often consulted either by patients or diving physicians regarding fitness to dive, and at present, the guidelines do not provide comprehensive information regarding the evaluation of this patient cohort. The aim of this review is to provide a comprehensive overview of existing otorhinolaryngological guidelines for fitness to dive recreationally...
February 15, 2018: JAMA Otolaryngology—Head & Neck Surgery
https://www.readbyqxmd.com/read/29448181/effect-of-beach-management-policies-on-recreational-water-quality
#5
Elizabeth A Kelly, Zhixuan Feng, Maribeth L Gidley, Christopher D Sinigalliano, Naresh Kumar, Allison G Donahue, Adrianus J H M Reniers, Helena M Solo-Gabriele
When beach water monitoring programs identify poor water quality, the causes are frequently unknown. We hypothesize that management policies play an important role in the frequency of fecal indicator bacteria (FIB) exceedances (enterococci and fecal coliform) at recreational beaches. To test this hypothesis we implemented an innovative approach utilizing large amounts of monitoring data (n > 150,000 measurements per FIB) to determine associations between the frequency of contaminant exceedances and beach management practices...
February 12, 2018: Journal of Environmental Management
https://www.readbyqxmd.com/read/29447910/preventing-non-contact-acl-injuries-in-female-athletes-what-can-we-learn-from-dancers
#6
Catherine Turner, Sarah Crow, Thomas Crowther, Brittany Keating, Trenton Saupan, Jason Pyfer, Kimberly Vialpando, Szu-Ping Lee
OBJECTIVES: To investigate the effects of dance experience and movement instruction on lower extremity kinematics and muscle activation during a landing task. DESIGN: Cross-sectional case control. SETTING: Laboratory setting. PARTICIPANTS: 27 female subjects (age 18-25) in 2 groups: dancers (n = 12) and non-dancers (n = 15). MAIN OUTCOME MEASURES: Lower extremity biomechanics during drop landing were analyzed...
December 23, 2017: Physical Therapy in Sport
https://www.readbyqxmd.com/read/29447545/effects-of-wearing-lower-leg-compression-sleeves-on-locomotion-economy
#7
Eduard Kurz, Christoph Anders
The purpose of this investigation was to assess the effect of compression sleeves on muscle activation cost during locomotion. Twenty-two recreationally active men (age: 25 ± 3 years) ran on a treadmill at four different speeds (ordered sequence of 2.8, 3.3, 2.2, and 3.9 m/s). The tests were performed without (control situation, CON) and while wearing specially designed lower leg compression sleeves (SL). Myoelectric activity of five lower leg muscles (tibialis anterior, fibularis longus, lateral and medial head of gastrocnemius, and soleus) was captured using Surface EMG...
February 15, 2018: Journal of Sports Sciences
https://www.readbyqxmd.com/read/29445137/metabolic-features-of-cancer-stem-cells-the-emerging-role-of-lipid-metabolism
#8
REVIEW
Rita Mancini, Alessia Noto, Maria Elena Pisanu, Claudia De Vitis, Marcello Maugeri-Saccà, Gennaro Ciliberto
Cancer stem cells (CSCs) are an uncommon subset of tumor cells capable of self-renewal, differentiating, and recreating the parental tumor when transplanted into the murine background. Over the past two decades, efforts toward understanding CSC biology culminated into identifying a set of signaling pathways sustaining "stemness". Nevertheless, while metabolic rewiring is nowadays considered a hallmark of cancer, no consensus has been reached on the metabolic features underlying the plastic nature of CSCs, which are capable of residing in a dormant state, and able to rapidly proliferate when the need to repopulate the tumor mass arises...
February 15, 2018: Oncogene
https://www.readbyqxmd.com/read/29443037/high-resolution-3d-imaging-of-the-human-pancreas-neuro-insular-network
#9
Elizabeth Butterworth, Wesley Dickerson, Vindhya Vijay, Kristina Weitzel, Julia Cooper, Eric W Atkinson, Jason E Coleman, Kevin J Otto, Martha Campbell-Thompson
Using traditional histological methods, researchers are hampered in their ability to image whole tissues or organs in large-scale 3D. Histological sections are generally limited to <20 µm as formalin fixed paraffin section on glass slides or <500 µm for free-floating fixed sections. Therefore, extensive efforts are required for serial sectioning and large-scale image reconstruction methods to recreate 3D for samples >500 µm using traditional methods. In addition, light scatters from macromolecules within tissues, particularly lipids, prevents imaging to a depth >150 µm with most confocal microscopes...
January 29, 2018: Journal of Visualized Experiments: JoVE
https://www.readbyqxmd.com/read/29441229/isolation-identification-and-pathological-effects-of-beach-sand-bacterial-extract-on-human-skin-keratinocytes-in-vitro
#10
Fazli Subhan, Raheem Shahzad, Isfahan Tauseef, Kashif Syed Haleem, Atta-Ur Rehman, Sajid Mahmood, In-Jung Lee
Background: Beaches are recreational spots for people. However, beach sand contains harmful microbes that affect human health, and there are no established methods for either sampling and identifying beach-borne pathogens or managing the quality of beach sand. Method: This study was conducted with the aim of improving human safety at beaches and augmenting the quality of the beach experience. Beach sand was used as a resource to isolate bacteria due to its distinctive features and the biodiversity of the beach sand biota...
2018: PeerJ
https://www.readbyqxmd.com/read/29439653/unexplained-chronic-liver-disease-in-ethiopia-a-cross-sectional-study
#11
Stian Magnus Staurung Orlien, Nejib Yusuf Ismael, Tekabe Abdosh Ahmed, Nega Berhe, Trine Lauritzen, Borghild Roald, Robert David Goldin, Kathrine Stene-Johansen, Anne Margarita Dyrhol-Riise, Svein Gunnar Gundersen, Marsha Yvonne Morgan, Asgeir Johannessen
BACKGROUND: Hepatitis B virus (HBV) infection is assumed to be the major cause of chronic liver disease (CLD) in sub-Saharan Africa. The contribution of other aetiological causes of CLD is less well documented and hence opportunities to modulate other potential risk factors are being lost. The aims of this study were to explore the aetiological spectrum of CLD in eastern Ethiopia and to identify plausible underlying risk factors for its development. METHODS: A cross-sectional study was undertaken between April 2015 and April 2016 in two public hospitals in Harar, eastern Ethiopia...
February 13, 2018: BMC Gastroenterology
https://www.readbyqxmd.com/read/29438900/sperm-quality-biomarkers-complement-reproductive-and-endocrine-parameters-in-investigating-environmental-contaminants-in-common-carp-cyprinus-carpio-from-the-lake-mead-national-recreation-area
#12
Jill A Jenkins, Michael R Rosen, Rassa O Draugelis-Dale, Kathy R Echols, Leticia Torres, Carla M Wieser, Constance A Kersten, Steven L Goodbred
Lake Mead National Recreational Area (LMNRA) serves as critical habitat for several federally listed species and supplies water for municipal, domestic, and agricultural use in the Southwestern U.S. Contaminant sources and concentrations vary among the sub-basins within LMNRA. To investigate whether exposure to environmental contaminants is associated with alterations in male common carp (Cyprinus carpio) gamete quality and endocrine- and reproductive parameters, data were collected among sub-basins over 7 years (1999-2006)...
February 10, 2018: Environmental Research
https://www.readbyqxmd.com/read/29438388/ancient-dna-analysis-of-indigenous-rockfish-use-on-the-pacific-coast-implications-for-marine-conservation-areas-and-fisheries-management
#13
Antonia T Rodrigues, Iain McKechnie, Dongya Y Yang
Rockfish (Sebastes spp.) are a common marine fish in nearshore and continental shelf environments in the North Pacific Ocean. They are frequently identified in coastal archaeological sites in western North America; however, the morphological similarity of rockfish species limits conventional zooarchaeological identifications to the genus level. This study applies ancient DNA analysis to 96 archaeological rockfish specimens from four sites on separate islands in an archipelago on western Vancouver Island, British Columbia, Canada...
2018: PloS One
https://www.readbyqxmd.com/read/29435760/prescribing-6-weeks-of-running-training-using-parameters-from-a-self-paced-maximal-oxygen-uptake-protocol
#14
James S Hogg, James G Hopker, Sarah L Coakley, Alexis R Mauger
PURPOSE: The self-paced maximal oxygen uptake test (SPV) may offer effective training prescription metrics for athletes. This study aimed to examine whether SPV-derived data could be used for training prescription. METHODS: Twenty-four recreationally active male and female runners were randomly assigned between two training groups: (1) Standardised (STND) and (2) Self-Paced (S-P). Participants completed 4 running sessions a week using a global positioning system-enabled (GPS) watch: 2 × interval sessions; 1 × recovery run; and 1 × tempo run...
February 12, 2018: European Journal of Applied Physiology
https://www.readbyqxmd.com/read/29435466/opana-er-oxymorphone-induced-thrombotic-microangiopathy-an-atypical-presentation-in-a-patient-with-hepatitis-c
#15
Hassan Mehmood, Muzammil Khan, Asghar Marwat, Medha Joshi, Varun Malhotra
Oxymorphone is a semisynthetic extended release opiate used to treat moderate to severe chronic pain. The Food and Drug Administration approved the oral form of oxymorphone available as Opana and Opana ER (extended release) since 2006. The Food and Drug Administration and the Centers for Disease Control and Prevention issued warning against intravenous use of Opana ER. We are presenting a case report of a 37-year-old female with a history of active intravenous drug abuse who presented to our hospital with acute kidney injury...
January 2018: Journal of Investigative Medicine High Impact Case Reports
https://www.readbyqxmd.com/read/29435251/transcriptome-response-of-atlantic-salmon-salmo-salar-to-competition-with-ecologically-similar-non-native-species
#16
Xiaoping He, Aimee Lee S Houde, Bryan D Neff, Daniel D Heath
Non-native species may be introduced either intentionally or unintentionally, and their impact can range from benign to highly disruptive. Non-native salmonids were introduced into Lake Ontario, Canada, to provide recreational fishing opportunities; however, the establishment of those species has been proposed as a significant barrier to the reintroduction of native Atlantic salmon (Salmo salar) due to intense interspecific competition. In this study, we compared population differences of Atlantic salmon in transcriptome response to interspecific competition...
February 2018: Ecology and Evolution
https://www.readbyqxmd.com/read/29434550/select-skeletal-muscle-mrnas-related-to-exercise-adaptation-are-minimally-affected-by-different-pre-exercise-meals-that-differ-in-macronutrient-profile
#17
Pim Knuiman, Maria T E Hopman, Jeroen A Wouters, Marco Mensink
Background: Substantial research has been done on the impact of carbohydrate and fat availability on endurance exercise adaptation, though its role in the acute adaptive response to resistance exercise has yet to be fully characterized. Purpose: We aimed to assess the effects of a pre-resistance exercise isocaloric mixed meal containing different amounts of carbohydrates and fat, on post-resistance exercise gene expression associated with muscle adaptation. Methods: Thirteen young (age 21.2 ± 1.6 year), recreationally trained (VO 2max 51...
2018: Frontiers in Physiology
https://www.readbyqxmd.com/read/29433896/generating-tissue-resident-macrophages-from-pluripotent-stem-cells-lessons-learned-from-microglia
#18
Christel Claes, Johanna Van den Daele, Catherine M Verfaillie
Over the past decades, the importance of the immune system in a broad scope of pathologies, has drawn attention towards tissue-resident macrophages, such as microglia in the brain. To enable the study of for instance microglia, it is crucial to recreate in vitro (and in vivo) assays. However, very fast loss of tissue-specific features of primary tissue resident macrophages, including microglia, upon in vitro culture has complicated such studies. Moreover, limited knowledge of macrophage developmental pathways and the role of local 'niche factors', has hampered the generation of tissue-resident macrophages from pluripotent stem cells (PSC)...
February 2, 2018: Cellular Immunology
https://www.readbyqxmd.com/read/29433575/uses-and-importance-of-wild-fungi-traditional-knowledge-from-the-tshopo-province-in-the-democratic-republic-of-the-congo
#19
Héritier Milenge Kamalebo, Hippolyte Nshimba Seya Wa Malale, Cephas Masumbuko Ndabaga, Jérôme Degreef, André De Kesel
BACKGROUND: Wild mushrooms constitute an important non-timber forest product that provides diverse substances and services, especially food and income for local communities from many parts of the world. This study presents original ethnomycological documentation from the dense rainforests of the Democratic Republic of the Congo. METHODS: Ethnomycological surveys were made within local communities near the biosphere reserve of Yangambi and the Yoko forest reserve...
February 12, 2018: Journal of Ethnobiology and Ethnomedicine
https://www.readbyqxmd.com/read/29433177/trabecular-anatomy-of-the-axis-vertebra-a-study-of-shaded-volume-rendered-computed-tomography-images
#20
K Venugopal Menon, Sameer B Raniga
BACKGROUND: To date, trabecular morphology studies have been conducted on thin-section computed tomography (CT) scans of cadaveric bone. Here we describe the trabecular anatomy of the axis vertebra as revealed by an innovative imaging tool. METHODS: Ten patients who underwent thin-slice CT scans for suspected cervical spine injury were prospectively subjected to shaded volume-rendered 3-dimensional reconstruction of the images. The trabecular anatomy thus depicted was recreated, and the mechanical vectors were deduced independently by a senior radiologist and spine surgeon and then matched...
February 2018: World Neurosurgery
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