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nutrition* AND lung cancer

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https://www.readbyqxmd.com/read/29145841/rehabilitation-for-cancer-patients-at-black-lion-hospital-addis-ababa-ethiopia-a-cross-sectional-study
#1
Teshager Worku, Zuriash Mengistu, Agumasie Semahegn, Gezahegn Tesfaye
BACKGROUND: In Ethiopia, there were greater than 2000 adult and 200 pediatric cancer patients annually in 2010, but the estimated number of cancer patients were increasing. Oncologic rehabilitation treatment may result in improved physical and mental impairment. There is a paucity of information about rehabilitation service utilization among cancer patients in Ethiopia. Hence, the purpose of this study was to assess the rehabilitation service for cancer patient and associated factors at Black Lion hospital, Addis Ababa, Ethiopia...
November 16, 2017: BMC Palliative Care
https://www.readbyqxmd.com/read/29142398/cytotoxic-antimitotic-and-antiproliferation-studies-on-rasam-a-south-indian-traditional-functional-food
#2
Agilandeswari Devarajan, M K Mohan Maruga Raja
Background: Rasam is a traditional South Indian food, prepared using tamarind juice as a base, with a variety of spices. Rasam, with all its ingredients medicinally claimed for various ailments, is a functional food. Systematic consumption of traditional functional food provides an excellent preventive measure to ward off many diseases. Objective: To study rasam for cytotoxic, antimitotic, and antiproliferation potential beyond its culinary and nutritional effect...
October 2017: Pharmacognosy Magazine
https://www.readbyqxmd.com/read/29137238/significance-of-nlda-the-commixed-index-of-inflammation-immune-responses-hemostasis-and-nutrition-for-predicting-metastatic-non-small-cell-lung-cancer-prognosis-and-metastases
#3
Wen-Wen Sun, Jia-An Hu, Wen-Quan Niu, Bei-Li Gao, Zhi-Hong Xu
Purpose: This study aimed to take a comprehensive review of the hematological indexes and discover a novel, comprehensive, and economical index for prognostic prediction. Results: The predictive prognostic model revealed that an elevated value of NLDA (NLDA = neutrophil count/lymphocyte count × D-dimer count/albumin) was an independent risk factor for one-year adverse prognosis (hazard ratio = 3.038; 95% confidence interval [CI], 1.959-4.712; P < 0.001). The C-indexes of internal and external validation in nomogram were 0...
October 10, 2017: Oncotarget
https://www.readbyqxmd.com/read/29129231/the-association-between-the-index-of-nutritional-quality-inq-and-breast-cancer-and-the-evaluation-of-nutrient-intake-of-breast-cancer-patients-a-case-control-study
#4
Farhad Vahid, Mahshid Hatami, Mahya Sadeghi, Fatemeh Ameri, Zeinab Faghfoori, Sayed Hossein Davoodi
OBJECTIVE: Breast cancer (BrCa) is the most frequently diagnosed cancer among females and second cancer after lung cancer in many societies. In Iran, the risk for BrCa is 1 in 35 and each year, 8000 new patients have been diagnosed with BrCa. Studies have shown that dietary components are implicated in the etiology of BrCa. The Index of Nutritional Quality (INQ) is a method of quantitative and qualitative analysis of single foods, meals, and diets. The aim of this study was to determine the usefulness of INQs in predicting BrCa risk...
January 2018: Nutrition
https://www.readbyqxmd.com/read/29113668/preoperative-geriatric-nutritional-risk-index-a-predictive-and-prognostic-factor-in-patients-with-pathological-stage-i-non-small-cell-lung-cancer
#5
Fumihiro Shoji, Taichi Matsubara, Yuka Kozuma, Naoki Haratake, Takaki Akamine, Shinkichi Takamori, Masakazu Katsura, Gouji Toyokawa, Tatsuro Okamoto, Yoshihiko Maehara
BACKGROUND: Surgical outcomes of early-stage non-small cell lung cancer (NSCLC) are poor. The Geriatric Nutritional Risk Index (GNRI) is a useful parameter for evaluating nutritional status. We aimed to investigate if preoperative GNRI could be a predictive factor for pathological stage I NSCLC patients. PATIENTS AND METHODS: We retrospectively selected 141 consecutive pathological stage I NSCLC patients treated from August 2005 to August 2010. We analyzed their preoperative GNRI in univariate and multivariate Cox regression analyses for postoperative recurrence-free survival (RFS)...
December 2017: Surgical Oncology
https://www.readbyqxmd.com/read/29089030/systemic-immune-inflammation-index-predicting-chemoradiation-resistance-and-poor-outcome-in-patients-with-stage-iii-non-small-cell-lung-cancer
#6
Yu-Suo Tong, Juan Tan, Xi-Lei Zhou, Ya-Qi Song, Ying-Jian Song
BACKGROUND: There is increasing evidence that the existence of systemic inflammation response is correlated with poor prognosis in several solid tumors. The aim of this retrospective study was to investigate the association between systemic immune-inflammation index (SII) and therapy response and overall survival in patients with stage III non-small cell lung cancer (NSCLC). The prognostic values of neutrophil to lymphocyte ratio (NLR), platelet to lymphocyte ratio (PLR), and prognostic nutritional index (PNI) were also evaluated...
October 31, 2017: Journal of Translational Medicine
https://www.readbyqxmd.com/read/29082005/maternal-and-child-health-services-and-an-integrated-life-cycle-approach-to-the-prevention-of-non-communicable-diseases
#7
REVIEW
Luisa Brumana, Alvaro Arroyo, Nina R Schwalbe, Susanna Lehtimaki, David B Hipgrave
Described as the 'invisible epidemic', non-communicable diseases (NCDs) are the world's leading cause of death. Most are caused by preventable factors, including poor diet, tobacco use, harmful use of alcohol and physical inactivity. Diabetes, cancer and cardiovascular and chronic lung diseases were responsible for 38 million (68%) of global deaths in 2012. Since 1990, proportionate NCD mortality has increased substantially as populations have aged and communicable diseases decline. The majority of NCD deaths, especially premature NCD deaths (<70 years, 82%), occur in low-income and middle-income countries, and among poor communities within them...
2017: BMJ Global Health
https://www.readbyqxmd.com/read/29070616/results-from-the-european-prospective-investigation-into-cancer-and-nutrition-epic-link-vitamin-b6-catabolism-and-lung-cancer-risk
#8
Hui Zuo, Per Magne Ueland, Øivind Midttun, Stein E Vollset, Grethe S Tell, Despoina Theofylaktopoulou, Ruth C Travis, Marie-Christine Boutron-Ruault, Agnes Fournier, Gianluca Severi, Marina Kvaskoff, Heiner Boeing, Manuela Bergmann, Renée Turzanski Fortner, Rudolf Kaaks, Antonia Trichopoulou, Anastasia Kotanidou, Pagona Lagiou, Domenico Palli, Sabina Sieri, Salvatore Panico, H B As Bueno-de-Mesquita, Petra H Peeters, Kjell Grankvist, Mikael Johansson, Antonio Agudo, Jose Ramón Quirós Garcia, Nerea Larrañaga, Maria-Jose Sanchez, Maria-Dolores Chirlaque, Eva Ardanaz, Shu-Chun Chuang, Valentina Gallo, Paul Brennan, Mattias Johansson, Arve Ulvik
Circulating pyridoxal-5'-phosphate (PLP) has been linked to lung cancer risk. The PAr index, defined as the ratio 4-pyridoxic acid / (pyridoxal + PLP), reflects increased vitamin B6 catabolism during inflammation. PAr has been defined as a marker of lung cancer risk in a prospective cohort study, but analysis of a larger numbers of cases are needed to deepen the significance of this study. Here we conducted a nested case-control study within the European Prospective Investigation into Cancer and Nutrition (EPIC, n = 521,330), which included 892 incident lung cancer cases and 1748 controls matched by center, gender, date of blood collection and date of birth...
October 25, 2017: Cancer Research
https://www.readbyqxmd.com/read/29056570/activity-and-safety-of-azd3759-in-egfr-mutant-non-small-cell-lung-cancer-with-cns-metastases-bloom-a-phase-1-open-label-dose-escalation-and-dose-expansion-study
#9
Myung-Ju Ahn, Dong-Wan Kim, Byoung Chul Cho, Sang-We Kim, Jong Seok Lee, Jin-Seok Ahn, Tae Min Kim, Chia-Chi Lin, Hye Ryun Kim, Thomas John, Steven Kao, Jonathan W Goldman, Wu-Chou Su, Ronald Natale, Sarit Rabbie, Bryony Harrop, Philip Overend, Zhenfan Yang, James Chih-Hsin Yang
BACKGROUND: CNS metastases-including brain and leptomeningeal metastases-from epidermal growth factor receptor (EGFR)-mutant non-small-cell lung cancer (NSCLC) are associated with poor prognosis. AZD3759 is a novel EGFR tyrosine kinase inhibitor with high capability to penetrate the blood-brain barrier. We aimed to assess the safety, tolerability, pharmacokinetics, and efficacy of AZD3759 in patients with EGFR-mutant NSCLC with brain and leptomeningeal metastases. METHODS: This open-label, multicentre, phase 1 study was undertaken at 11 centres and hospitals in Australia, South Korea, Taiwan, and the USA...
October 17, 2017: Lancet Respiratory Medicine
https://www.readbyqxmd.com/read/29049803/prognostic-significance-of-immune-nutritional-parameters-for-surgically-resected-elderly-lung-cancer-patients-a-multicentre-retrospective-study
#10
Fumihiro Shoji, Naoko Miura, Taichi Matsubara, Takaki Akamine, Yuka Kozuma, Naoki Haratake, Shinkichi Takamori, Masakazu Katsura, Kazuki Takada, Gouji Toyokawa, Tomoyoshi Takenaka, Koji Yamazaki, Tatsuro Okamoto, Sadanori Takeo, Yoshihiko Maehara
OBJECTIVES: The world's population is rapidly ageing, and the age of patients with lung cancer will increase as well. The prognostic nutritional index, controlling nutritional status and the geriatric nutritional risk index (GNRI) are useful parameters for evaluating immune-nutritional status. We aimed to perform a multicentre retrospective study to investigate the correlations of these immune-nutritional parameters with postoperative comorbidities or surgical outcomes of elderly patients with non-small-cell lung cancer (NSCLC)...
October 16, 2017: Interactive Cardiovascular and Thoracic Surgery
https://www.readbyqxmd.com/read/29033850/designing-dietary-recommendations-using-system-level-interactomics-analysis-and-network-based-inference
#11
Tingting Zheng, Yueqiong Ni, Jun Li, Billy K C Chow, Gianni Panagiotou
Background: A range of computational methods that rely on the analysis of genome-wide expression datasets have been developed and successfully used for drug repositioning. The success of these methods is based on the hypothesis that introducing a factor (in this case, a drug molecule) that could reverse the disease gene expression signature will lead to a therapeutic effect. However, it has also been shown that globally reversing the disease expression signature is not a prerequisite for drug activity. On the other hand, the basic idea of significant anti-correlation in expression profiles could have great value for establishing diet-disease associations and could provide new insights into the role of dietary interventions in disease...
2017: Frontiers in Physiology
https://www.readbyqxmd.com/read/29025257/utility-of-the-national-lung-screening-trial-criteria-for-estimation-of-lung-cancer-in-the-korean-population
#12
Ye Jin Lee, Sun Mi Choi, Jinwoo Lee, Chang-Hoon Lee, Sang-Min Lee, Chul-Gyu Yoo, Young Whan Kim, Sung Koo Han, Young Sik Park
Purpose: Screening for lung cancer in high-risk patients using the National Lung Screening Trial (NLST) criteria resulted in a decreased lung cancer-related mortality rate. However, whether these criteria are applicable to the Korean has not been investigated thus far. Therefore, we estimated the utility of the NLST criteria as a screening tool for lung cancer in the Korean population. Materials and Methods: The total number of newly diagnosed lung cancer cases in 2013 was obtained from the Korea National Statistical Office...
October 12, 2017: Cancer Research and Treatment: Official Journal of Korean Cancer Association
https://www.readbyqxmd.com/read/28986018/cystic-fibrosis-disorders-of-the-large-intestine-dios-constipation-and-colorectal-cancer
#13
James M Abraham, Christopher J Taylor
Since 1966 when the Cystic Fibrosis Foundation Patient Registry (CFFPR) was founded, clinicians have witnessed significant advances in both the quality and quantity of life for patients living with Cystic Fibrosis (CF). As patients with CF live longer and fuller lives, increasing encumbrances from gastrointestinal manifestations of CF will be observed. This article serves to discuss "below the diaphragm" concerns involving the large intestine (Distal Intestinal Obstruction Syndrome, Constipation, and Colorectal Cancer)...
November 2017: Journal of Cystic Fibrosis: Official Journal of the European Cystic Fibrosis Society
https://www.readbyqxmd.com/read/28940119/the-relationship-between-physical-activity-obesity-and-lung-cancer-risk-by-smoking-status-in-a-large-prospective-cohort-of-us-adults
#14
Alpa V Patel, Brian D Carter, Victoria L Stevens, Mia M Gaudet, Peter T Campbell, Susan M Gapstur
Physical activity has been associated with lower lung cancer risk in numerous studies with estimates ranging from 20 to 50% lower risk in the most versus the least active study participants. Underweight and obesity have also been associated with lower lung cancer risk, with a nonlinear, inverted U-shaped relationship. However, associations of physical activity and obesity with lung cancer are likely significantly confounded by smoking since individuals who smoke are generally less active and leaner than non-smokers, but few studies have examined these associations stratified by smoking status...
September 22, 2017: Cancer Causes & Control: CCC
https://www.readbyqxmd.com/read/28937796/delay-of-lung-adenocarcinoma-lac-1-development-in-mice-by-dietary-oleic-acid
#15
Mariana Piegari, Elio A Soria, Aldo R Eynard, Mirta A Valentich
Lung cancer is the leading cause of death by cancer, and is a major sanitary concern worldwide. Some nutrients, such as ω-9 fatty acids, have been proposed as anticancer agents. Thus, an olein-enriched diet was assayed in a murine model of lung adenocarcinoma (LAC-1) to evaluate neoplastic and paraneoplastic evolution in BALB/c mice. The organic assimilation of dietary fatty acids was confirmed in liver by gas chromatography. This experimental oleic acid-containing diet increased animal survival and tumour latency (analysed by the Kaplan-Meier method), improving neoplastic evolution and general status, with weak effects on the paraneoplastic syndrome (thymus atrophy, splenomegaly, splenocyte response to mitogen, blood anaemia, and leucocytosis)...
September 22, 2017: Nutrition and Cancer
https://www.readbyqxmd.com/read/28922778/circulating-folate-vitamin-b6-and-methionine-in-relation-to-lung-cancer-risk-in-the-lung-cancer-cohort-consortium-lc3
#16
Anouar Fanidi, David C Muller, Jian-Min Yuan, Victoria L Stevens, Stephanie J Weinstein, Demetrius Albanes, Ross Prentice, Cynthia A Thomsen, Mary Pettinger, Qiuyin Cai, William J Blot, Jie Wu, Alan A Arslan, Anne Zeleniuch-Jacquotte, Marjorie L McCullough, Loic Le Marchand, Lynne R Wilkens, Christopher A Haiman, Xuehong Zhang, Jiali Han, Meir J Stampfer, Stephanie A Smith-Warner, Edward Giovannucci, Graham G Giles, Allison M Hodge, Gianluca Severi, Mikael Johansson, Kjell Grankvist, Arnulf Langhammer, Steinar Krokstad, Marit Næss, Renwei Wang, Yu-Tang Gao, Lesley M Butler, Woon-Puay Koh, Xiao-Ou Shu, Yong-Bing Xiang, Honglan Li, Wei Zheng, Qing Lan, Kala Visvanathan, Judith Hoffman Bolton, Per Magne Ueland, Øivind Midttun, Arve Ulvik, Neil E Caporaso, Mark Purdue, Regina G Ziegler, Neal D Freedman, Julie E Buring, I-Min Lee, Howard D Sesso, J Michael Gaziano, Jonas Manjer, Ulrika Ericson, Caroline Relton, Paul Brennan, Mattias Johansson
Background: Circulating concentrations of B vitamins and factors related to one-carbon metabolism have been found to be strongly inversely associated with lung cancer risk in the European Prospective Investigation into Cancer and Nutrition (EPIC) study. The extent to which these associations are present in other study populations is unknown. Methods: Within 20 prospective cohorts from the National Cancer Institute Cohort Consortium, a nested case-control study was designed including 5364 incident lung cancer case patients and 5364 control subjects who were individually matched to case patients by age, sex, cohort, and smoking status...
January 1, 2018: Journal of the National Cancer Institute
https://www.readbyqxmd.com/read/28860112/risk-factors-for-falls-in-older-patients-with-cancer
#17
Xiaotao Zhang, Ming Sun, Suyu Liu, Cheuk Hong Leung, Linda Pang, Uday R Popat, Richard Champlin, Holly M Holmes, Vicente Valero, Colin P Dinney, Debu Tripathy, Beatrice J Edwards
OBJECTIVES: A rising number of patients with cancer are older adults (65 years of age and older), and this proportion will increase to 70% by the year 2020. Falls are a common condition in older adults. We sought to assess the prevalence and risk factors for falls in older patients with cancer. METHODS: This is a single-site, retrospective cohort study. Patients who were receiving cancer care underwent a comprehensive geriatric assessments, including cognitive, functional, nutritional, physical, falls in the prior 6 months and comorbidity assessment...
August 31, 2017: BMJ Supportive & Palliative Care
https://www.readbyqxmd.com/read/28845591/mitochondrial-degeneration-precedes-the-development-of-muscle-atrophy-in-progression-of-cancer-cachexia-in-tumour-bearing-mice
#18
Jacob L Brown, Megan E Rosa-Caldwell, David E Lee, Thomas A Blackwell, Lemuel A Brown, Richard A Perry, Wesley S Haynie, Justin P Hardee, James A Carson, Michael P Wiggs, Tyrone A Washington, Nicholas P Greene
BACKGROUND: Cancer cachexia is largely irreversible, at least via nutritional means, and responsible for 20-40% of cancer-related deaths. Therefore, preventive measures are of primary importance; however, little is known about muscle perturbations prior to onset of cachexia. Cancer cachexia is associated with mitochondrial degeneration; yet, it remains to be determined if mitochondrial degeneration precedes muscle wasting in cancer cachexia. Therefore, our purpose was to determine if mitochondrial degeneration precedes cancer-induced muscle wasting in tumour-bearing mice...
August 28, 2017: Journal of Cachexia, Sarcopenia and Muscle
https://www.readbyqxmd.com/read/28843267/screening-for-circulating-tumour-cells-allows-early-detection-of-cancer-and-monitoring-of-treatment-effectiveness-an-observational-study
#19
Karin Ried, Peter Eng, Avni Sali
Background: Circulating-Tumour-Cells (CTC) provide a blood biomarker for early carcinogenesis, cancer progression and treatment effectiveness. An increase in CTCs is associated with cancer progression, a CTC decrease with cancer containment or remission. Several technologies have been developed to identify CTC, including the validated Isolation-by-Size-of-Epithelial-Tumour (ISET, Rarecells) technology, combining blood filtration and microscopy using standard histo-pathological criteria. Methods: This observational study compared CTC count to cancer status and cancer risk, by monitoring treatment effectiveness in cancer patients and by screening for CTC in asymptomatic patients with risk factors, including family history of cancer...
August 27, 2017: Asian Pacific Journal of Cancer Prevention: APJCP
https://www.readbyqxmd.com/read/28826375/nature-nurture-and-cancer-risks-genetic-and-nutritional-contributions-to-cancer
#20
REVIEW
Evropi Theodoratou, Maria Timofeeva, Xue Li, Xiangrui Meng, John P A Ioannidis
It is speculated that genetic variants are associated with differential responses to nutrients (known as gene-diet interactions) and that these variations may be linked to different cancer risks. In this review, we critically evaluate the evidence across 314 meta-analyses of observational studies and randomized controlled trials of dietary risk factors and the five most common cancers (breast, lung, prostate, colorectal, and stomach). We also critically evaluate the evidence across 13 meta-analyses of observational studies of gene-diet interactions for the same cancers...
August 21, 2017: Annual Review of Nutrition
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