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nutrition* AND lung cancer

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https://www.readbyqxmd.com/read/29779814/should-omega-3-fatty-acids-be-used-for-adjuvant-treatment-of-cancer-cachexia
#1
REVIEW
Daryna Sergiyivna Lavriv, Pedro Miguel Neves, Paula Ravasco
OBJECTIVES: Cancer cachexia is characterised by a progressive loss of muscle, resulting in functional impairment and shorter survival. Therefore, omega-3 has been studied for its role as an anti-cachectic therapy. This systematic review identified studies published on use of omega-3 in cancer cachexia in order to examine the potential benefit. METHODS: A systematic review of the literature using PubMed and B-on databases was conducted to identify clinical trials published between 2000 and 2015, to evaluate the effect of n-3 PUFAs on nutritional features and Quality of Life in cancer cachexia...
June 2018: Clinical Nutrition ESPEN
https://www.readbyqxmd.com/read/29732484/crispr-cas9-the-powerful-new-genome-editing-tool-for-putative-therapeutics-in-obesity
#2
REVIEW
María José Franco-Tormo, Mireille Salas-Crisostomo, Nuno Barbosa Rocha, Henning Budde, Sérgio Machado, Eric Murillo-Rodríguez
The molecular technology known as clustered regularly interspaced palindromic repeats (CRISPR)/CRISPR-associated protein (Cas) is revolutionizing the field of medical research and deepening our understanding of numerous biological processes. The attraction of CRISPR/Cas9 lies in its ability to efficiently edit DNA or modulate gene expression in living eukaryotic cells and organisms, a technology that was once considered either too expensive or scientifically risky. CRISPR/Cas9 has been successfully applied in agriculture to develop the next generation of disease-resistant plants...
May 7, 2018: Journal of Molecular Neuroscience: MN
https://www.readbyqxmd.com/read/29731164/influence-of-wellness-education-on-first-line-icotinib-hydrochloride-patients-with-stage-iv-non-small-cell-lung-cancer-and-their-family-caregivers
#3
Li Yanwei, Fang Minghui, Quan Manman, Yan Zhuchun, Liu Dongying, Pan Zhanyu
OBJECTIVE: This study aims to examine the effects of wellness education (WE) intervention on the behavioral change, psychological status, performance status on patients with stage IV non-small cell lung cancer (NSCLC) undergoing icotinib hydrochloride treatment and their relationships with family caregivers. METHODS: We conducted an intervention study involving 126 individuals with confirmed activating epidermal growth factor receptor mutation-positive stage IV NSCLC who received icotinib hydrochloride as first-line therapy between January 2014 and January 2016; their caregivers were also included in the study...
April 11, 2018: Current Problems in Cancer
https://www.readbyqxmd.com/read/29716592/pollution-and-respiratory-disease-can-diet-or-supplements-help-a-review
#4
REVIEW
T Whyand, J R Hurst, M Beckles, M E Caplin
Pollution is known to cause and exacerbate a number of chronic respiratory diseases. The World Health Organisation has placed air pollution as the world's largest environmental health risk factor. There has been recent publicity about the role for diet and anti-oxidants in mitigating the effects of pollution, and this review assesses the evidence for alterations in diet, including vitamin supplementation in abrogating the effects of pollution on asthma and other chronic respiratory diseases. We found evidence to suggest that carotenoids, vitamin D and vitamin E help protect against pollution damage which can trigger asthma, COPD and lung cancer initiation...
May 2, 2018: Respiratory Research
https://www.readbyqxmd.com/read/29697283/antitumoral-potency-by-immunomodulation-of-chloroform-extract-from-leaves-of-nitraria-retusa-tunisian-medicinal-plant-via-its-major-compounds-%C3%AE-sitosterol-and-palmitic-acid-in-balb-c-mice-bearing-induced-tumor
#5
Jihed Boubaker, Imene Ben Toumia, Aicha Sassi, Imen Bzouich-Mokded, Sonia Ghoul Mazgar, Fairouz Sioud, Ahmed Bedoui, Sihem Safta Skhiri, Kamel Ghedira, Leila Chekir-Ghedira
This study evaluated the antitumoral effect of Chloroform extract from Nitraria retusa leaves, via its major compounds β-sitosterols and palmitic acid. BALB/c mice were subcutaneously inoculated with B16-F10 cells, then treated intra-peritoneally after 7 days with the chloroform extract for 21 days. They were then euthanized, and the tumors were weighed. Lung parenchyma was analyzed. Lymphocyte and macrophages proliferation, cytotoxic T lymphocyte (CTL) activities were evaluated using the MTT assay. Macrophage phagocytosis was evaluated by measuring the lysosomal activity and nitric oxide production...
May 2018: Nutrition and Cancer
https://www.readbyqxmd.com/read/29690722/-dynamic-investigation-of-nutritional-risk-in-patients-with-malignant-tumor-during-hospitalization
#6
M W Zhu, J M Wei, W Chen, X Yang, H Y Cui, S N Zhu, P P Zhang, J Xiong, D F Zheng, H J Song, X Y Liang, L Zhang, W Y Xu, H B Wang, G Q Su, L J Feng, T Chen, Y D Wu, H Li, J Q Sun, Y Shi, B D Tong, S M Zhou, X Y Wang, Y H Huang, B M Zhang, J Xu, H Y Zhang, G L Chang, Z Y Jia, S F Chen, J Hu, X W Zhang, H Wang, Z D Li, Y Y Gao, B Gui
Objective: To prospectively investigate the changes in nutritional status of patients with malignant tumors during hospitalization by using nutritional risk screening (NRS2002), and to analyze the correlation between the nutritional status and clinical outcomes . Methods: This was a prospective and parallel research done by multi-center collaboration from 34 hospitals in China from June to September 2014.Hospitalized patients with malignant tumors inthese departments (Department of Gastroenterology, respiratory medicine, oncology, general surgery, thoracic surgery and geriatrics)were investigated...
April 10, 2018: Zhonghua Yi Xue za Zhi [Chinese medical journal]
https://www.readbyqxmd.com/read/29685760/preoperative-nutritional-status-assessment-predicts-postoperative-outcomes-in-patients-with-surgically-resected-non-small-cell-lung-cancer
#7
Ricard Ramos, Ernest Nadal, Inma Peiró, Cristina Masuet-Aumatell, Ivan Macia, Francisco Rivas, Gabriela Rosado, Pau Rodriguez, Anna Ureña, Susana Padrones, Samantha Aso, Carlos Deniz, Arturo Navarro, Ignacio Escobar
BACKGROUND: As nutritional status plays an important role in outcomes after surgery, this study evaluated the association between preoperative nutritional status (NS) and postoperative outcomes after major resection for lung cancer. METHODS: We identified 219 patients with a diagnosis of cancer who underwent pulmonary resection from 2010 to 2012. Preoperative NS was assessed by anthropometric and biological parameters, body mass index (BMI), and the Nutritional Risk Index (NRI)...
April 11, 2018: European Journal of Surgical Oncology
https://www.readbyqxmd.com/read/29684049/clinical-factors-associated-with-early-progression-and-grade-3-4-toxicity-in-patients-with-advanced-non-small-cell-lung-cancers-treated-with-nivolumab
#8
Coraline Dumenil, Marie-Ange Massiani, Jennifer Dumoulin, Violaine Giraud, Sylvie Labrune, Thierry Chinet, Etienne Giroux Leprieur
INTRODUCTION: The prognosis of advanced non-small-cell lung cancer (NSCLC) has been improved by development of immune checkpoint inhibitors (ICIs) such as nivolumab for second-line treatment. As phase III trials include only selected patients, we here investigated the clinical factors associated with efficacy and safety of nivolumab in 'real life' patients with advanced NSCLC. METHODS: Clinical and histological characteristics, therapies and survival data of all consecutive patients with advanced NSCLC included prospectively and treated by nivolumab in two French academic hospitals between February 2015 and December 2016 were examined...
2018: PloS One
https://www.readbyqxmd.com/read/29658597/antitumoral-effect-of-ocoxin-a-natural-compound-containing-nutritional-supplement-in-small-cell-lung-cancer
#9
Elena Díaz-Rodríguez, Eduardo Sanz, Atanasio Pandiella
Lung cancer is the most frequently diagnosed neoplasia and represents the leading cause of cancer-related deaths worldwide. Due to this fact, efforts to improve patient survival through the introduction of novel therapies, as well as preventive actions, are urgently required. Considering this scenario, the antitumoral action of the composite formulation Ocoxin® oral solution (OOS), that contains several antitumoral compounds including antioxidants, was tested in small cell lung cancer (SCLC) in vitro and in vivo preclinical models...
April 16, 2018: International Journal of Oncology
https://www.readbyqxmd.com/read/29653085/prognostic-significance-of-pre-resection-albumin-fibrinogen-ratio-in-patients-with-non-small-cell-lung-cancer-a-propensity-score-matching-analysis
#10
Shuaishuai Chen, Haixi Yan, Juping Du, Jun Li, Bo Shen, Haijian Ying, Ying Zhang, Shiyong Chen
BACKGROUND: Nutrition and coagulation play important roles in cancer progression. This study was aimed to investigate the value of the albumin/fibrinogen ratio (AFR) in non-small cell lung cancer (NSCLC) patients, through a propensity score matching (PSM) method. METHODS: We retrospectively analyzed 529 NSCLC patients underwent surgical resection from 2010 to 2015. PSM was used to eliminate possible biases. A Cox proportional hazards regression model was performed to evaluate the prognostic value of AFR in NSCLC...
April 10, 2018: Clinica Chimica Acta; International Journal of Clinical Chemistry
https://www.readbyqxmd.com/read/29569334/determinants-of-quality-of-life-in-lung-cancer-patients
#11
Hsiu-Yu Hung, Li-Min Wu, Kang-Pan Chen
PURPOSE: To examine the relationships of self-care, symptoms, and a variety of demographic factors to quality of life (QOL), and to identify determinants of QOL in lung cancer patients undergoing chemotherapy. DESIGN: A cross-sectional, correlational study. METHODS: 159 patients with lung cancer undergoing chemotherapy were recruited from three southern hospitals in Taiwan. Four instruments were used: the Quality of Life Questionnaire Core 30-item (QLQ-C30), M...
March 23, 2018: Journal of Nursing Scholarship
https://www.readbyqxmd.com/read/29566473/comparative-study-of-esophageal-self-expandable-metallic-stent-insertion-and-gastrostomy-feeding-for-dysphagia-caused-by-lung-cancer
#12
Jihye Kim, Yang Won Min, Hyuk Lee, Byung Hoon Min, Joon Haeng Lee, Poong Lyul Rhee, Jae J Kim
Background/Aims: Dysphagia is encountered in a large proportion of patients with lung cancer and is associated with malnutrition and a poor quality of life. This study compared the clinical outcomes of self-expandable metallic stent (SEMS) insertion and percutaneous gastrostomy (PG) feeding for patients with lung cancer and dysphagia. Methods: A total of 261 patients with lung cancer, who underwent either SEMS insertion (stent group) or PG (gastrostomy group) as an initial treatment procedure for dysphagia between July 1997 and July 2015 at the Samsung Medical Center, were reviewed retrospectively, and 84 patients with esophageal obstruction were identified...
March 25, 2018: Korean Journal of Gastroenterology, Taehan Sohwagi Hakhoe Chi
https://www.readbyqxmd.com/read/29558830/naturopathic-oncology-care-for-thoracic-cancers-a-practice-survey
#13
Dugald Seely, Julie K Ennis, Ellen McDonell, Linlu Zhao
BACKGROUND AND OBJECTIVES: There is a lack of information on therapies recommended by naturopathic doctors (NDs) for lung and gastroesophageal cancer care. Study objectives were to: (1) identify the most common interventions considered for use by NDs; (2) identify interventions NDs recommend to support key therapeutic goals; and (3) identify potential contraindications between integrative and conventional therapies. METHODS: Oncology Association of Naturopathic Physicians (OncANP) members (n = 351) were invited to complete an electronic survey...
March 1, 2018: Integrative Cancer Therapies
https://www.readbyqxmd.com/read/29550881/the-effect-of-nabilone-on-appetite-nutritional-status-and-quality-of-life-in-lung-cancer-patients-a-randomized-double-blind-clinical-trial
#14
Jenny G Turcott, María Del Rocío Guillen Núñez, Diana Flores-Estrada, Luis F Oñate-Ocaña, Zyanya Lucia Zatarain-Barrón, Feliciano Barrón, Oscar Arrieta
BACKGROUND: Over one half of the patients diagnosed with advanced lung cancer experience anorexia. In addition to its high incidence, cancer-induced anorexia promotes the development of the anorexia-cachexia syndrome, which is related to poor clinical outcomes. Recently, drugs derived from cannabinoids, such as Nabilone, have been recognized for their appetite improvement properties; however, clinical trials to support their use in cancer patients are necessary. METHODS: This is a randomized, double-blind, placebo-controlled clinical trial to assess the effect of Nabilone vs...
March 17, 2018: Supportive Care in Cancer: Official Journal of the Multinational Association of Supportive Care in Cancer
https://www.readbyqxmd.com/read/29528442/preoperative-prognostic-nutritional-index-as-a-predictor-of-outcomes-in-elderly-patients-after-surgery-for-lung-cancer
#15
Isamu Watanabe, Naoki Kanauchi, Hikaru Watanabe
Background and objective: The prognostic nutritional index (PNI) is based on the serum albumin level and lymphocyte count, and is a useful predictor of survival in various cancers. However, the utility of PNI in lung cancer has not been examined. The aim of this study is to assess PNI as a prognostic factor in elderly patients after surgery for primary lung cancer. Methods: A retrospective review was performed in 131 elderly patients (≥75 years old) with lung cancer who underwent curative operations at our hospital from July 2008 to December 2014...
April 1, 2018: Japanese Journal of Clinical Oncology
https://www.readbyqxmd.com/read/29516990/clinical-study-on-thalidomide-combined-with-cinobufagin-to-treat-lung-cancer-cachexia
#16
Mingzhi Xie, Xiaoju Chen, Shouming Qin, Yongjian Bao, Kunpeng Bu, Yang Lu
Objective: To discuss and assess the clinical value of treating lung cancer cachexia with thalidomide combined with cinobufagin.s. Methods: A cohort of 54 patients, who were diagnosed with lung carcinoma, was randomly divided into two groups, a trial group and a control group, respectively. The trial group was given 150 mg/day thalidomide and 2700 mg/day cinobufagin; the control group only received 2,700 mg/day cinobufagin. The therapy lasted for 12 weeks, and the nutritional status, quality of life, survival, and side effects in patients in the two groups were recorded...
January 2018: Journal of Cancer Research and Therapeutics
https://www.readbyqxmd.com/read/29450756/risk-stratification-according-to-the-prognostic-nutritional-index-for-predicting-postoperative-complications-after-lung-cancer-surgery
#17
Satoru Okada, Junichi Shimada, Satoshi Teramukai, Daishiro Kato, Hiroaki Tsunezuka, Naoko Miyata, Shunta Ishihara, Tatsuo Furuya, Chiaki Nakazono, Narumi Ishikawa, Masayoshi Inoue
BACKGROUND: The prognostic nutritional index (PNI), an immune nutritional marker based on serum albumin levels and total lymphocyte count, predicts postoperative complications in various types of malignancies. However, the clinical significance of the PNI for postoperative complications following lung cancer surgery is uncertain. METHODS: Patients with resected non-small cell lung cancer (n = 515) were retrospectively analyzed and the relationship between the preoperative PNI and postoperative complications was evaluated...
May 2018: Annals of Surgical Oncology
https://www.readbyqxmd.com/read/29442459/the-usefulness-of-routinely-used-malnutrition-screening-tools-in-predicting-anemia-in-lung-cancer-patients
#18
Katarzyna A Zabłocka-Słowińska, Monika Kosacka, Irena Porębska, Konrad Pawełczyk, Marcin Gołecki, Jadwiga Biernat, Halina Grajeta
BACKGROUND: Anemia and malnutrition are frequently observed during lung cancer development, and the associations between them have been researched. However, no study concerning the utility of routinely used nutritional screening tools in predicting anemia in lung cancer has been performed. OBJECTIVES: The aim of this study was to assess the usefulness of routinely used malnutrition screening tools in predicting anemia in lung cancer patients. MATERIAL AND METHODS: Eighty-five male patients were recruited to this study...
December 2017: Advances in Clinical and Experimental Medicine: Official Organ Wroclaw Medical University
https://www.readbyqxmd.com/read/29427194/the-relationship-between-nutritional-status-and-handgrip-strength-in-adult-cancer-patients-a-cross-sectional-study
#19
Şenay Burçin Alkan, Mehmet Artaç, Neslişah Rakıcıoğlu
PURPOSE: Malnutrition is a common complication in head, neck and lung cancer patients, particularly in cases of gastrointestinal system (GIS) cancer. Therefore, an assessment of malnutrition is crucial for early nutritional interventions. It was conducted as a cross-sectional study to evaluate nutritional status of adult cancer patients. METHODS: The nutritional status of 104 cancer patients (52 GIS and 52 non-GIS cancer cases) using a Patient-Generated Subjective Global Assessment (PG-SGA), handgrip strength, certain anthropometric measurements and food consumption in and outside of the hospital were assessed...
February 9, 2018: Supportive Care in Cancer: Official Journal of the Multinational Association of Supportive Care in Cancer
https://www.readbyqxmd.com/read/29380845/occurrence-of-malnutrition-and-associated-factors-in-community-dwelling-older-adults-those-with-a-recent-diagnosis-of-cancer-are-at-higher-risk
#20
C Van Den Broeke, T De Burghgraeve, M Ummels, N Gescher, L Deckx, V Tjan-Heijnen, F Buntinx, M van den Akker
OBJECTIVES: In older adults, nutritional health is essential for good quality of life and living independently at home. Especially in cancer patients, malnutrition is common and known to complicate treatment. This study aims to evaluate the nutritional status and its associated factors in community-dwelling older adults with and without cancer. DESIGN: This is an observational study. SETTING: This study focuses on older community-dwelling people...
2018: Journal of Nutrition, Health & Aging
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