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https://www.readbyqxmd.com/read/29353374/bdnf-activates-mtor-to-upregulate-nr2b-expression-in-the-rostral-anterior-cingulate-cortex-required-for-inflammatory-pain-related-aversion-in-rats
#1
Yuangui Zhang, Fanceng Ji, Gongming Wang, Dong He, Le Yang, Mengyuan Zhang
The mechanistic target of rapamycin (mTOR) has been demonstrated to mediate pain-related aversion induced by formalin in the rostral anterior cingulate cortex (rACC). However, it remains unclear the signaling pathways and regulatory proteins involved. In the rACC, brain-derived neurotrophic factor (BDNF), an activity-dependent neuromodulator, has been shown to play a role in the development and persistence of chronic pain. In this study, we used a rat formalin-induced inflammatory pain model to demonstrate BDNF up-regulation in the rACC...
January 20, 2018: Neurochemical Research
https://www.readbyqxmd.com/read/29353302/-diazepam-loading-%C3%A2-can-a-strategy-for-preventing-alcohol-withdrawal-be-used-to-treat-benzodiazepine-use-disorder
#2
Clara Oliveras, Adriana Fortea, Laura Espinosa, Pablo Barrio, Anna Lligoña, Mercè Balcells-Olivero
Las benzodiacepinas se usan para tratar la abstinencia alcohólica siguiendo varias estrategias: dosis descendiente, dosis de carga, tratamiento en función de sintomatología. La carga de diazepam ha demostrado ser un tratamiento válido para la abstinencia alcohólica en ensayos controlados aleatorizados. Tras una búsqueda bibliográfica no sistemática, no hemos encontrado antecedentes en la literatura de una estrategia de carga de diazepam sin posterior administración de benzodiacepinas para el tratamiento de la abstinencia a éstas...
January 15, 2018: Adicciones
https://www.readbyqxmd.com/read/29353236/deep-brain-stimulation-for-parkinson-s-disease-defining-the-optimal-location-within-the-subthalamic-nucleus
#3
Maarten Bot, P Richard Schuurman, Vincent J J Odekerken, Rens Verhagen, Fiorella Maria Contarino, Rob M A De Bie, Pepijn van den Munckhof
BACKGROUND: Individual motor improvement after deep brain stimulation (DBS) of the subthalamic nucleus (STN) for Parkinson's disease (PD) varies considerably. Stereotactic targeting of the dorsolateral sensorimotor part of the STN is considered paramount for maximising effectiveness, but studies employing the midcommissural point (MCP) as anatomical reference failed to show correlation between DBS location and motor improvement. The medial border of the STN as reference may provide better insight in the relationship between DBS location and clinical outcome...
January 20, 2018: Journal of Neurology, Neurosurgery, and Psychiatry
https://www.readbyqxmd.com/read/29353224/coronary-microvascular-dysfunction-may-be-related-to-igf-1-in-acromegalic-patients-and-can-be-restored-by-therapy
#4
Sara Tellatin, Pietro Maffei, Elena Osto, Francesca Dassie, Giulia Famoso, Roberta Montisci, Chiara Martini, Francesco Fallo, Martina Perazzolo Marra, Roberto Mioni, Sabino Iliceto, Roberto Vettor, Francesco Tona
BACKGROUND AND AIMS: Acromegaly increases the risk of cardiovascular mortality. Data on the cardiovascular risk in asymptomatic acromegaly are limited. In particular, data on coronary microvascular abnormalities are lacking. We assessed coronary flow reserve (CFR) as a marker of coronary microvascular function in asymptomatic acromegaly. METHODS: We studied 40 acromegalic patients (23 male, age 52 ± 11 years) without clinical evidence of cardiovascular disease, and 40 control subjects matched for age and sex...
December 24, 2017: Atherosclerosis
https://www.readbyqxmd.com/read/29353213/multiple-cortical-thickness-sub-networks-and-cognitive-impairments-in-first-episode-drug-na%C3%A3-ve-patients-with-late-life-depression-a-graph-theory-analysis
#5
Jeong-Hyeon Shin, Yu Hyun Um, Chang Uk Lee, Hyun Kook Lim, Joon-Kyung Seong
BACKGROUND: Coordinated and pattern-wise changes in large scale gray matter structural networks reflect neural circuitry dysfunction in late life depression (LLD), which in turn is associated with emotional dysregulation and cognitive impairments. However, due to methodological limitations, there have been few attempts made to identify individual-level structural network properties or sub-networks that are involved in important brain functions in LLD. METHODS: In this study, we sought to construct individual-level gray matter structural networks using average cortical thicknesses of several brain areas to investigate the characteristics of the gray matter structural networks in normal controls and LLD patients...
January 5, 2018: Journal of Affective Disorders
https://www.readbyqxmd.com/read/29353138/competitive-swimmers-with-hypermobility-have-strength-and-fatigue-deficits-in-shoulder-medial-rotation
#6
Behnam Liaghat, Birgit Juul-Kristensen, Thomas Frydendal, Camilla Marie Larsen, Karen Søgaard, Aki Ilkka Tapio Salo
Generalised Joint Hypermobility including shoulder hypermobility (GJHS) in swimmers is considered an intrinsic risk factor for shoulder injuries. The aim was to investigate the association of GJHS with shoulder strength, fatigue development and muscle activity during swimming-related shoulder rotations. Totally, 38 competitive swimmers (aged 13-17 years) participated, 19 were competitive swimmers with GJHS and 19 were age, sex and club matched swimmers without GJHS. Concentric isokinetic force in medial and lateral rotations were measured at 60°/s (5 repetitions) and 180°/s (10 repetitions)...
January 10, 2018: Journal of Electromyography and Kinesiology
https://www.readbyqxmd.com/read/29352976/anterior-segment-imaging-for-angle-closure
#7
Sunee Chansangpetch, Prin Rojanapongpun, Shan C Lin
PURPOSE: To summarize the role of anterior segment imaging (AS-imaging) in angle closure diagnosis and management, and the possible advantages over the current standard of gonioscopy. DESIGN: Literature review and perspective. METHODS: Review of the pertinent publications with interpretation and perspective in relation to the use of AS-imaging in angle closure assessment focusing on anterior segment optical coherence tomography and ultrasound biomicroscopy...
January 15, 2018: American Journal of Ophthalmology
https://www.readbyqxmd.com/read/29352685/factors-associated-with-posterior-cruciate-ligament-tightness-during-cruciate-retaining-total-knee-arthroplasty
#8
Kazuhisa Hatayama, Masanori Terauchi, Shogo Hashimoto, Kenichi Saito, Hiroshi Higuchi
BACKGROUND: The purpose of our study was to identify factors affecting posterior cruciate ligament (PCL) tightness during cruciate-retaining total knee arthroplasty. METHODS: A total of 225 varus osteoarthritic knees that underwent cruciate-retaining total knee arthroplasty were included in this study. When the flexion gap was tighter than the extension gap after all bone resection and the lift-off sign was positive during surgery, the PCL was released. The association between PCL release and potential risk factors, such as age, gender, body mass index, preoperative range of motion, anterior cruciate ligament status, preoperative hip-knee-ankle angle (HKA), decrease in posterior condylar offset, and also change in tibial posterior slope angle (TPSA) from preoperative to postoperative measurement, was evaluated by univariate and multivariate logistic regression analyses...
December 28, 2017: Journal of Arthroplasty
https://www.readbyqxmd.com/read/29352669/tms-of-primary-motor-cortex-with-a-biphasic-pulse-activates-two-independent-sets-of-excitable-neurones
#9
Martin Sommer, Matteo Ciocca, Raffaella Chieffo, Paul Hammond, Andreas Neef, Walter Paulus, John C Rothwell, Ricci Hannah
BACKGROUND: Biphasic pulses produced by most commercially available TMS machines have a cosine waveform, which makes it difficult to study the interaction between the two phases of stimulation. OBJECTIVE: We used a controllable pulse TMS (cTMS) device delivering quasi-rectangular pulse outputs to investigate whether monophasic are more effective than biphasic pulses. METHODS: Temporally symmetric ("biphasic") or highly asymmetric ("monophasic") charge-balanced biphasic stimuli were used to target the hand area of motor cortex in the anterior-posterior (AP) or posterior-anterior (PA) initial current direction...
January 5, 2018: Brain Stimulation
https://www.readbyqxmd.com/read/29352436/posterolateral-tibial-plateau-fractures-how-to-buttress-reversed-l-posteromedial-or-the-posterolateral-approach-a-comparative-cadaveric-study
#10
Wich Orapiriyakul, Theerachai Apivatthakakul, Chanakarn Phornphutkul
INTRODUCTION: The selection of a surgical approach for buttressing posterolateral tibial plateau fractures is controversial. OBJECTIVE: This study compared the surgical exposure area between the reversed L posteromedial approach (R-PM) and the posterolateral (PL) approach using the lateral plateau width as a metric. MATERIALS AND METHODS: Twenty lower extremities from fresh frozen cadavers were included. The R-PM approach was used first and the boundary of the posterior tibial cortex exposure was marked with metal pins...
January 19, 2018: Archives of Orthopaedic and Trauma Surgery
https://www.readbyqxmd.com/read/29352361/the-modified-ravitch-approach-for-the-management-of-severe-anterior-flail-chest-with-bilateral-sternochondral-dislocations-a-case-report
#11
Gabriel Estremera, Ellen Chieko Omi, Eduardo Smith-Singares
The management of flail chest continues to evolve as scientific evidence and surgical experience accumulates. Flail chest injuries that span the sternum present a rare and complicated injury pattern that can be challenging to manage both medically and surgically. Our patient is a 69-year-old involved in a high-speed motor vehicle crash with respiratory failure secondary to an anterior flail chest. Tomographic examination confirmed a sternal fracture with bilateral sternochondral dislocations and multiple rib fractures...
January 19, 2018: Surgical Case Reports
https://www.readbyqxmd.com/read/29352127/structural-covariance-of-gray-matter-volume-in-hiv-vertically-infected-adolescents
#12
Jielan Li, Lei Gao, Zhi Wen, Jing Zhang, Panying Wang, Ning Tu, Hao Lei, Fuchun Lin, Xi'en Gui, Guangyao Wu
Human immunodeficiency virus (HIV) infection significantly affect neurodevelopmental and behavioral outcomes. We investigated whether alterations of gray matter organization and structural covariance networks with vertical HIV infection adolescents exist, by using the GAT toolbox. MRI data were analysed from 25 HIV vertically infected adolescents and 33 HIV-exposed-uninfected control participants. The gray matter volume (GMV) was calculated, and structural brain networks were reconstructed from gray matter co-variance...
January 19, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29352057/feasibility-complications-morbidity-and-mortality-results-at-6-months-for-aneurysm-treatment-with-the-flow-re-direction-endoluminal-device-report-of-safe-study
#13
Laurent Pierot, Laurent Spelle, Jérôme Berge, Anne-Christine Januel, Denis Herbreteau, Mohamed Aggour, Michel Piotin, Alessandra Biondi, Xavier Barreau, Charbel Mounayer, Chrisanthi Papagiannaki, Jean-Paul Lejeune, Jean-Yves Gauvrit, Vincent Costalat
BACKGROUND AND PURPOSE: Flow diverters are increasingly used for the treatment of intracranial aneurysms. Evaluation of the first devices available for clinical use showed high efficacy of this treatment although safety results were worse compared with coiling or balloon-assisted coiling. The Safety and Efficacy Analysis of FRED Embolic Device in Aneurysm Treatment (SAFE) trial is a single-arm, multicenter, prospective study conducted to precisely analyze the safety and efficacy of the FRED and FRED Jr devices...
January 19, 2018: Journal of Neurointerventional Surgery
https://www.readbyqxmd.com/read/29352054/increased-blood-brain-barrier-permeability-in-contralateral-hemisphere-predicts-worse-outcome-in-acute-ischemic-stroke-after-reperfusion-therapy
#14
Chang Liu, Shenqiang Yan, Ruiting Zhang, Zhicai Chen, Feina Shi, Ying Zhou, Meixia Zhang, Min Lou
AIMS: We sought to investigate the risk factors of blood-brain barrier (BBB) disruption, and its potential impact on 90-day clinical outcome in acute ischemic stroke (AIS) patients after reperfusion therapy. METHODS: Consecutive acute anterior circulation AIS patients imaged with computed tomographic perfusion (CTP) before reperfusion therapy were included. Tmax >6 s was used for the volumetric measurement of the hypoperfusion area. BBB permeability (BBBP) was calculated as the average relative permeability-surface area product (rPS) within the hypoperfusion region (rPShypo-i) and its contralateral mirror region (rPShypo-c) on CTP-derived PS color maps...
January 19, 2018: Journal of Neurointerventional Surgery
https://www.readbyqxmd.com/read/29351937/anterior-choroidal-artery-infarction
#15
Swaleha Nadaf, Rahul T Chakor, Kaumil Vipul Kothari, Bhagyadhan A Patel
No abstract text is available yet for this article.
January 18, 2018: BMJ Case Reports
https://www.readbyqxmd.com/read/29351793/retinal-complications-of-gout-a-case-report-and-review-of-the-literature
#16
Ying Jiang, Jason E Brenner, William J Foster
BACKGROUND: There have been few reported findings of posterior segment complications of gout. While exudative lesions, an increased risk of macular degeneration, and vascular occlusions have been previously reported, to our knowledge, refractile macular lesions have not been reported in a patient with chronic uncontrolled gout. CASE PRESENTATION: Highly refractile, crystal-like lesions were found in the macula of a 62 year old male patient with chronically uncontrolled gout...
January 19, 2018: BMC Ophthalmology
https://www.readbyqxmd.com/read/29351708/eyelid-reconstruction-pediculated-versus-non-pediculated
#17
Sonja Frimmel, Christoph Kniestedt, Karla Chaloupka
BACKGROUND: To compare the functional and cosmetic outcome of pediculated versus free anterior and posterior lamella reconstruction after large eyelid defects due to malignancy excision. PATIENTS AND METHODS: A retrospective study over 2 years with 12 patients matching the criterion of pediculated versus non-pediculated transplants out of a cohort of 124 tumor excisions. The mean age was 76 ± 8 years of the 7 male and 5 female patients. In the majority of cases, more than half of the eyelid was excised...
January 19, 2018: Klinische Monatsblätter Für Augenheilkunde
https://www.readbyqxmd.com/read/29351689/microvascular-decompression-for-patients-with-hemifacial-spasm-associated-with-common-trunk-anomaly-of-the-cerebellar-arteries-case-study-and-review-of-literature
#18
Ehab El Refaee, Christian Rosenstengel, Joerg Baldauf, Dirk T Pillich, Marc Matthes, Henry W S Schroeder
BACKGROUND: Few previous studies have described the origin of both anterior and posterior inferior cerebellar arteries from one vessel as a common trunk anomaly. No previous studies have clearly described the aforementioned anomaly depending on intraoperative endoscopic visualization. OBJECTIVE: To evaluate the association of a common trunk anomaly with hemifacial spasm, which makes microvascular decompression more challenging. METHODS: All patients with common trunk anomaly associated with hemifacial spasm who received surgical treatment between 2006 and 2015 in our institution were identified in our prospectively collected database...
February 1, 2018: Operative Neurosurgery (Hagerstown, Md.)
https://www.readbyqxmd.com/read/29351683/novel-bilateral-extracavitary-approach-for-thoracolumbar-decompression
#19
Jeffrey P Mullin, Alvin Y Chan, Emily Bennett, Michael P Steinmetz
BACKGROUND: Bilateral extracavitary approach (BECA) is an option for decompression cases that require a more extended ventral approach. The clear advantage is increased accessibility to the most ventral aspects of the spine from a bilateral perspective. OBJECTIVE: To assess the safety and efficacy of thoracic and thoracolumbar decompression and/or reconstruction from BECA. METHODS: A retrospective chart review was performed reviewing all patients who underwent BECA for thoracolumbar decompression from 2003 to 2012 at our institution...
February 1, 2018: Operative Neurosurgery (Hagerstown, Md.)
https://www.readbyqxmd.com/read/29351682/radial-artery-fascial-flow-through-free-flap-for-combined-revascularization-in-moyamoya-disease
#20
Jonathan Russin, Joseph Carey
BACKGROUND: Free flaps are commonly used by other surgical subspecialties for soft tissue reconstruction and revascularization. Cranial applications of these flaps have been limited to only a single case report. OBJECTIVE: To present a new technique for combined revascularization in moyamoya disease using a flow-through free flap. METHODS: Data were obtained from an Institutional Review Board-approved, prospectively maintained database with informed consent from the patient...
February 1, 2018: Operative Neurosurgery (Hagerstown, Md.)
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