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https://www.readbyqxmd.com/read/28749618/radiation-induced-second-cancer-risk-from-external-beam-photon-radiotherapy-for-head-and-neck-cancer-impact-on-in-field-and-out-of-field-organs
#1
Vasanthan Sakthivel, Ganesh Kadirampatti Mani, Sunil Mani, Raghavendiran Boopathy
The purpose of this paper is to provide data on development of second primary cancers within or adjacent to tissue irradiated in the treatment of primary head and neck cancers using different techniques and modalities. Materials and methods: We selected five patients with HandN tumors located in base of the tongue for risk assessment. In order to examine the impact of choices of various planning techniques, numbers of beams and beam energy used in treatment plans - 7 and 9 field Intensity modulated radiotherapy (IMRT) plans using 6MV and 10 MV beam energies and a 6MV Volumetric modulated arc therapy (VMAT) plans were planned...
July 27, 2017: Asian Pacific Journal of Cancer Prevention: APJCP
https://www.readbyqxmd.com/read/28749373/dosimetric-evaluation-of-a-commercial-proton-spot-scanning-monte-carlo-dose-algorithm-comparisons-against-measurements-and-simulations
#2
Jatinder Saini, Dominic Maes, Alexander Egan, Stephen R Bowen, Sara St James, Martin Janson, Tony Wong, Charles Bloch
RaySearch Americas Inc. (NY) has introduced a commercial Monte Carlo dose algorithm (RS-MC) for routine clinical use in proton spot scanning. In this report, we provide a validation of this algorithm against phantom measurements and simulations in GATE/GEANT4 software package. We also compared the performance of RayStation analytical algorithm (RS-PBA) against the RS-MC algorithm. Methods: A beam model (G-MC) for spot scanning gantry at our proton center was implemented in the GATE software package. The model was validated against measurements in a water phantom and was used for benchmarking the RS-MC...
July 27, 2017: Physics in Medicine and Biology
https://www.readbyqxmd.com/read/28749332/human-myiasis-caused-by-the-reindeer-warble-fly-hypoderma-tarandi-case-series-from-norway-2011-to-2016
#3
Jörgen Landehag, Andreas Skogen, Kjetil Åsbakk, Boris Kan
Hypoderma tarandi causes myiasis in reindeer and caribou (Rangifer tarandus spp.) in most northern hemisphere regions where these animals live. We report a series of 39 human myiasis cases caused by H. tarandi in Norway from 2011 to 2016. Thirty-two were residents of Finnmark, the northernmost county of Norway, one a visitor to Finnmark, and six lived in other counties of Norway where reindeer live. Clinical manifestations involved migratory dermal swellings of the face and head, enlargement of regional lymph nodes, and periorbital oedema, with or without eosinophilia...
July 20, 2017: Euro Surveillance: Bulletin Européen sur les Maladies Transmissibles, European Communicable Disease Bulletin
https://www.readbyqxmd.com/read/28749317/understanding-the-use-of-geographical-information-systems-gis-in-health-informatics-research-a-review
#4
Nicola Shaw, Suzanne McGuire
BACKGROUND: The purpose of this literature review is to understand geographical information systems (GIS) and how they can be applied to public health informatics, medical informatics, and epidemiology. METHOD: Relevant papers that reflected the use of geographical information systems (GIS) in health research were identified from four academic databases: Academic Search Complete, BioMed Central, PubMed Central, and Scholars Portal, as well as Google Scholar. The search strategy used was to identify articles with "geographic information systems", "GIS", "public health", "medical informatics", "epidemiology", and "health geography" as main subject headings or text words in titles and abstracts...
June 23, 2017: Journal of Innovation in Health Informatics
https://www.readbyqxmd.com/read/28749307/recurrent-ear-mite-otodectes-cynotis-infestation-in-three-related-groups-of-patagonian-cavies-dolichotis-patagonum
#5
Carolina Lopes da Cruz, Torres Alpino, Jack Kottwitz
:  Two of three groups of Patagonian cavies ( Dolichotis patagonum ) contracted Otodectes cynotis infestations after exposure to mite-infested feral cats. Otodectes cynotis infestations were initially identified in 9 of 10 cavies in group 1. Multiple feral cats with O. cynotis infestations were observed in the vicinity of the Patagonian cavies and were subsequently removed. The Patagonian cavies were initially treated with ivermectin (0.4 mg/kg s.q.) every 2 wk, but ivermectin was discontinued after the third treatment due to injury to one of the Patagonian cavies during capture...
June 2017: Journal of Zoo and Wildlife Medicine: Official Publication of the American Association of Zoo Veterinarians
https://www.readbyqxmd.com/read/28749302/squamous-cell-carcinoma-in-two-snow-leopards-uncia-uncia-with-unusual-auricular-presentation
#6
Benoît Quintard, Eva Maria Greunz, Brice Lefaux, Karin Lemberger, Antoine Leclerc
Squamous cell carcinoma (SCC) is well documented in snow leopards ( Uncia uncia ) and most common locations are oral, facial, or pedal. These two cases illustrate an unusual auricular presentation, which is more often reported in white domestic cats. The animals were aged and presented clinical signs of otitis such as head shaking and ear scratching. Clinical examinations showed auricular canal masses with chronic purulent otitis. In both cases, clinical deterioration led to euthanasia and histology of the ear canal was consistent with SCC and showed numerous vascular emboli...
June 2017: Journal of Zoo and Wildlife Medicine: Official Publication of the American Association of Zoo Veterinarians
https://www.readbyqxmd.com/read/28749266/epidemiologic-evaluation-of-elephant-endotheliotropic-herpesvirus-3b-infection-in-an-african-elephant-loxodonta-africana
#7
Ellen Bronson, Michael McClure, Jennifer Sohl, Ellen Wiedner, Sherry Cox, Erin M Latimer, Virginia R Pearson, Gary S Hayward, Angela Fuery, Paul D Ling
This epidemiologic study follows a 5-yr-old male African elephant ( Loxodonta africana ) during an episode of hemorrhagic disease (HD) due to elephant endotheliotropic herpesvirus 3B (EEHV3B) utilizing data from complete blood counts, electrophoresis and acute phase protein analysis, and polymerase chain reaction (PCR) of multiple body fluids during and after the clinical episode. The elephant presented with sudden onset of marked lethargy and inappetence followed by hypersalivation, hyperemia of the conjunctivae and focally on the tongue, and swellings on the head and ventrum...
June 2017: Journal of Zoo and Wildlife Medicine: Official Publication of the American Association of Zoo Veterinarians
https://www.readbyqxmd.com/read/28749195/hippo-pathway-contributes-to-cisplatin-resistant-induced-emt-in-nasopharyngeal-carcinoma-cells
#8
Shuo Li, Xiaomeng Zhang, Rongkai Zhang, Zibin Liang, Wei Liao, Zhengde Du, Chunsheng Gao, Fei Liu, Yunping Fan, Haiyu Hong
Nasopharyngeal carcinoma (NPC) is a kind of head-neck malignant tumor derived from the nasopharyngeal epithelium and is mainly prevalent in Southern China and Southeast Asia countries. Cisplatin (DDP) provides the first-line therapeutic administration in NPC patients. However, chemoresistance has been a main barrier and caused bad treatment outcome in NPC therapy. To understand the molecular mechanism of acquired resistance to DDP, multiple methods were performed to examine the morphocytology and molecular changes in DDP-resistant NPC cells...
July 27, 2017: Cell Cycle
https://www.readbyqxmd.com/read/28749163/development-of-a-paediatric-head-voxel-model-database-for-dosimetric-applications
#9
Andreas Stratis, Nathan Touyz, Guozhi Zhang, Reinhilde Jacobs, Ria Bogaerts, Hilde Bosmans
OBJECTIVES: To develop a database of paediatric head voxel models intended for Monte Carlo (MC) dosimetric applications. METHODS: Seventeen head and neck CT image datasets were retrieved from the Picture Archiving and Communicating System (PACS) of our hospital and were reformed into voxel models. Twenty two organs were segmented at each dataset. The segmented organ masses were compared to the respective age and gender specific ICRP reference mass value. Adjustments were made such that segmented and reference mass values coincide within a tolerance of 10%...
July 27, 2017: British Journal of Radiology
https://www.readbyqxmd.com/read/28749120/effects-of-tobacco-habits-on-the-polymorphism-of-nfkb1-and-nfkb1a-gene-of-head-and-neck-squamous-cell-carcinoma-in-indian-population
#10
Abhishek Gupta, Vertica Agnihotri, Rahul Kumar, Ashish Datt Upadhyay, Suman Bhaskar, Sadanand Dwivedi, Sharmistha Dey
Background: Polymorphism of NFKB1 and NFKB1A are highly associated with cancer. We have assessed polymorphism in the promoter region of NFKB1 -94 del/ins ATTG (rs28362491) and NFKB1A -826 C/T (rs2233406) with the risk of HNSCC in Indian population. Methods: Polymerase chain reaction–restriction fragment length polymorphism (PCR-RFLP) method was used for the genotyping NFKB1 -94 del/ins ATTG and NFKB1A -826 C/T. Sequencing was done to validate the results of PCR-RFLP. Statistical analysis of data was done by Stata/SE-14...
July 27, 2017: Asian Pacific Journal of Cancer Prevention: APJCP
https://www.readbyqxmd.com/read/28749050/-please-amputate-my-child-s-arms
#11
Mary Devereaux, Dennis John Kuo
Jeremy sustained bilateral complete brachial plexus injuries in an auto collision on an icy road a month before his third birthday. The accident rendered both upper extremities completely flail and insensate: he has no motor or sensory function of his shoulders, elbows, wrists, or digits. Jeremy does, however, have normal function of the lower extremities. Physical therapists have worked with the child for over a year with no noted improvement in arm function. Jeremy falls frequently, causing injury to his face and head, and occasionally, his arms get twisted or caught in his crib and his fingers turn blue...
July 2017: Hastings Center Report
https://www.readbyqxmd.com/read/28748971/follicular-dendritic-cell-sarcoma-of-the-head-and-neck-literature-review-and-report-of-the-tonsil-occurrence-in-a-ugandan-patient
#12
I Pecorella, T R Okello, G Ciardi, E Ochola, M D Ogwang
We report a case of follicular dendritic cell sarcoma (FDCS) in a 60-year-old Ugandan female who presented with a 6-year history of a progressive left sided tonsillary mass. General systemic examination was unrevealing and the patient underwent left tonsillectomy. She was subsequently lost to follow-up. Grossly, the mass measured 6 cm in diameter and had a mottled appearance due to tissue microhaemorrhages. Markers specific for follicular dendritic cell differentiation (CD21, CD35 and CD23), p53 and EGFR were expressed on immunohistochemical analysis...
June 2017: Pathologica
https://www.readbyqxmd.com/read/28748696/ultrasound-characterization-of-microbead-and-cell-suspensions-by-speed-of-sound-measurements-of-neutrally-buoyant-samples
#13
Kevin Wallace Cushing, Fabio Garofalo, Cecilia Magnusson, Lars Ekblad, Henrik Bruus, Thomas Laurell
We present an experimental method including error analysis for the measurement of the density and compressibility of cells and microbeads; these being the two central material properties in ultrasound-based acoustophoretic applications such as particle separation, trapping, and up-concentration. The density of the microparticles is determined by using a neutrally-buoyant selection process that involves centrifuging of microparticles suspended in different density solutions, CsCl for microbeads and Percoll for cells...
July 27, 2017: Analytical Chemistry
https://www.readbyqxmd.com/read/28748684/prognostic-factors-in-head-and-neck-melanoma-according-to-facial-aesthetic-units
#14
Giovanni Paolino, Michele Cardone, Dario Didona, Elisa Moliterni, Luigi Losco, Paola Corsetti, Giusy Schipani, Teresa Lopez, Stefano Calvieri, Ugo Bottoni
BACKGROUND: Head and neck melanoma is a clinical challenge. Indeed, cutaneous head and neck melanoma shows a worse prognosis in comparison to melanomas of other body sites. Although the emphasis on facial cosmetic preservation plays a pivotal role in comparison to other body areas, specific facial aesthetic units could also play a key role in the prognostic evaluation of the malignancy. METHODS: The aim of the current study was to evaluate the general outcome and clinicopathological features of head and neck melanoma and to detect prognostic differences according to each facial aesthetic unit...
July 26, 2017: Giornale Italiano di Dermatologia e Venereologia: Organo Ufficiale, Società Italiana di Dermatologia e Sifilografia
https://www.readbyqxmd.com/read/28748624/the-relationship-between-coping-style-and-psychological-distress-in-people-with-head-and-neck-cancer-a-systematic-review
#15
REVIEW
Nicolle Morris, Nima Moghaddam, Anna Tickle, Sanchia Biswas
OBJECTIVE: Individuals diagnosed with head and neck cancer (HNC) are at an elevated risk of experiencing psychological distress and a reduced quality of life. The aim of this review was to systematically examine and assess the quality of empirical evidence on the associations between coping mechanisms and psychological distress among people with HNC. METHODS: CINAHL, MEDLINE, PsycINFO, EMBASE and Web of Science were accessed to conduct this review. Studies were included if they used reliable and valid measures to investigate the relationship between coping style and psychological distress...
July 27, 2017: Psycho-oncology
https://www.readbyqxmd.com/read/28748562/visualization-of-macrophage-recruitment-in-head-and-neck-carcinoma-model-using-fluorine-19-magnetic-resonance-imaging
#16
Aman Khurana, Fanny Chapelin, Hongyan Xu, Joseph R Acevedo, Alfred Molinolo, Quyen Nguyen, Eric T Ahrens
PURPOSE: To evaluate the role of infiltrating macrophages in murine models of single and double mutation head and neck tumors using a novel fluorine-19 ((19) F) MRI technology. METHODS: Tumor cell lines single-hit/SCC4 or double-hit/Cal27, with mutations of TP53 and TP53 & FHIT, respectively, were injected bilaterally into the flanks of (n = 10) female mice. With tumors established, perfluorocarbon nanoemulsion was injected intravenously, which labels in situ predominantly monocytes and macrophages...
July 26, 2017: Magnetic Resonance in Medicine: Official Journal of the Society of Magnetic Resonance in Medicine
https://www.readbyqxmd.com/read/28748540/particulate-matter-pm-s-adheres-to-human-hair-exposed-to-severe-aerial-pollution-consequences-for-certain-hair-surface-properties
#17
Anthony Galliano, Chengda Ye, Fengjie Su, Chad Wang, Yin Wang, Chen Liu, Anupama Wagle, Myriam Guerin, Frédéric Flament, Andrew Steel
BACKGROUND: The deposit and adherence of particulate matter (PM's) from aerial pollution onto the surface of human hair is a poorly studied phenomenon. OBJECTIVES: i) To reproduce in vitro the deposit of known PM's on standardized hair swatches in a closed box, ii) to compare in vitro data with those obtained under "real life" conditions of severe aerial pollution, iii) to assess the changes of the hair surface properties, potentially caused by the adherence of airborne PM's onto the hair...
July 26, 2017: International Journal of Cosmetic Science
https://www.readbyqxmd.com/read/28748496/huperzine-a-alleviates-neuroinflammation-oxidative-stress-and-improves-cognitive-function-after-repetitive-traumatic-brain-injury
#18
Zhengrong Mei, Peiying Zheng, Xiangping Tan, Ying Wang, Bing Situ
Traumatic brain injury (TBI) may trigger secondary injury cascades including endoplasmic reticulum stress, oxidative stress, and neuroinflammation. Unfortunately, there are no effective treatments targeting either primary or secondary injuries that result in long-term detrimental consequences. Huperzine A (HupA) is a potent acetylcholinesterase inhibitor (AChEI) that has been used treatment of Alzheimer's disease (AD). This study aimed to explore the neuroprotective effects of HupA in TBI and its possible mechanisms...
July 26, 2017: Metabolic Brain Disease
https://www.readbyqxmd.com/read/28748276/resuming-the-obsolete-term-small-head-when-microcephaly-occurs-without-cognitive-impairment
#19
Piero Pavone, Andrea D Praticò, Martino Ruggieri, Renata Rizzo, Raffaele Falsaperla
Microcephaly is defined as a head circumference measurement of 2 or 3 standard deviations below the mean for age and sex. However, distinguishing the value of -2 or -3 standard deviations as a cutoff is relevant in the clinical practice, since the limit of -3 standard deviations is more frequently associated with cognitive impairment. The use of ultrasound scans in pregnancy has allowed the identification of subjects with a measurement of the head circumference at the limit of the cutoff for gestational age, but who do not subsequently show cognitive delay...
July 26, 2017: Neurological Sciences
https://www.readbyqxmd.com/read/28748275/head-trauma-and-parkinson-s-disease-results-from-an-italian-case-control-study
#20
Alessandra Nicoletti, Rosario Vasta, Giovanni Mostile, Giuseppe Nicoletti, Gennarina Arabia, Giovanni Iliceto, Paolo Lamberti, Roberto Marconi, Letterio Morgante, Paolo Barone, Aldo Quattrone, Mario Zappia
We evaluated the possible association between head trauma and Parkinson's disease (PD). The FRAGAMP (Fattori di Rischio Ambientali e Genetici Associati alla Malattia di Parkinson) study is a large Italian multicenter case-control study carried out to evaluate the possible role of environmental and genetic factors in PD. Cases and controls were enrolled from six movement disorders centers located in the Central-Southern Italy. A standardized questionnaire was administered to record demographic, epidemiological, and clinical data...
July 26, 2017: Neurological Sciences
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