keyword
MENU ▼
Read by QxMD icon Read
search

oncogenetics

keyword
https://www.readbyqxmd.com/read/27899992/beside-p53-and-pten-identification-of-molecular-alterations-of-the-ras-mapk-and-pi3k-akt-signaling-pathways-in-high-grade-serous-ovarian-carcinomas-to-determine-potential-novel-therapeutic-targets
#1
Shuhui Chen, Elisa Cavazza, Catherine Barlier, Julia Salleron, Pierre Filhine-Tresarrieu, Céline Gavoilles, Jean-Louis Merlin, Alexandre Harlé
Despite great histological and molecular heterogeneity, the clinical management of high-grade ovarian carcinomas remains unspecialized. As a major subgroup, high-grade serous ovarian carcinomas (HGSOCs) require novel therapies. In addition to utilizing conventional histological prognostic markers and performing oncogenetic investigations, the molecular diagnostic method of next generation sequencing (NGS) was performed to identify 'druggable' targets that could provide access to innovative therapy. The present study was performed in 45 HGSOC patients (mean age, 59...
November 2016: Oncology Letters
https://www.readbyqxmd.com/read/27793035/performance-of-multiplicom-s-brca-mastr-dx-kit-on-the-detection-of-brca1-and-brca2-mutations-in-fresh-frozen-ovarian-and-breast-tumor-samples
#2
Cindy Badoer, Céline Garrec, Dirk Goossens, Gillian Ellison, John Mills, Mélina Dzial, Hakim El Housni, Sarah Berwouts, Paola Concolino, Virginie Guibert-Le Guevellou, Capucine Delnatte, Jurgen Del Favero, Ettore Capoluongo, Stéphane Bézieau
Next-generation sequencing (NGS) has enabled new approaches for detection of mutations in the BRCA1 and BRCA2 genes responsible for hereditary breast and ovarian cancer (HBOC). The search for germline mutations in the BRCA1 and BRCA2 genes is of importance with respect to oncogenetic and surgical (bilateral mastectomy, ovariectomy) counselling. Testing tumor material for BRCA mutations is of increasing importance for therapeutic decision making as the poly ADP ribose polymerase (PARP) inhibitor, olaparib, is now available to treat patients with specific forms of ovarian cancer and BRCA mutations...
October 25, 2016: Oncotarget
https://www.readbyqxmd.com/read/27769293/bracavenir-impact-of-a-psychoeducational-intervention-on-expectations-and-coping-in-young-women-aged-18-30-years-exposed-to-a-high-familial-breast-ovarian-cancer-risk-study-protocol-for-a-randomized-controlled-trial
#3
Fabrice Kwiatkowski, Pascal Dessenne, Claire Laquet, Jean-Pierre Daures, Mathilde Gay-Bellile, Yves-Jean Bignon
BACKGROUND: Young women exposed to a high hereditary breast and ovarian cancer (HBOC) risk are particularly vulnerable. They are ignored by health prevention measures but exposed to a stream of contradictory information (medicine, media, Internet). They may feel concerned about surgical prevention issues at a key moment of their identity construction (self, relationship, sexuality). We designed a special psychoeducational intervention to help these women cope better with these difficulties...
October 21, 2016: Trials
https://www.readbyqxmd.com/read/27737507/oncogenic-events-rather-than-antigen-selection-pressure-may-be-the-main-driving-forces-for-relapse-in-diffuse-large-b-cell-lymphomas
#4
David Rizzo, Pierre-Julien Viailly, Sylvain Mareschal, Elodie Bohers, Jean-Michel Picquenot, Dominique Penther, Sydney Dubois, Vinciane Marchand, Philippe Bertrand, Catherine Maingonnat, Pascaline Etancelin, Jean Feuillard, Christian Bastard, Hervé Tilly, Fabrice Jardin, Philippe Ruminy
Little is known on the phylogenetic relationship between diagnostic and relapse clones of Diffuse Large B-Cell Lymphoma (DLBCL). We applied High Throughput Sequencing (HTS) of the VDJ locus of Immunoglobulin Heavy chain (IGHV) on fourteen DLBCL patients with serial samples, including tumor biopsies and/or peripheral blood mononuclear cells (PBMC). Phylogenetic data were consolidated with targeted sequencing and cytogenetics. Phylogeny clearly showed that DLBCL relapse could occur according either an early or a late divergent mode...
October 13, 2016: American Journal of Hematology
https://www.readbyqxmd.com/read/27727438/cosmic-high-resolution-cancer-genetics-using-the-catalogue-of-somatic-mutations-in-cancer
#5
S A Forbes, D Beare, N Bindal, S Bamford, S Ward, C G Cole, M Jia, C Kok, H Boutselakis, T De, Z Sondka, L Ponting, R Stefancsik, B Harsha, J Tate, E Dawson, S Thompson, H Jubb, P J Campbell
COSMIC (http://cancer.sanger.ac.uk) is an expert-curated database of somatic mutations in human cancer. Broad and comprehensive in scope, recent releases in 2016 describe over 4 million coding mutations across all human cancer disease types. Mutations are annotated across the entire genome, but expert curation is focused on over 400 key cancer genes. Now encompassing the majority of molecular mutation mechanisms in oncogenetics, COSMIC additionally describes 10 million non-coding mutations, 1 million copy-number aberrations, 9 million gene-expression variants, and almost 8 million differentially methylated CpGs...
October 11, 2016: Current Protocols in Human Genetics
https://www.readbyqxmd.com/read/27726213/early-onset-breast-cancer-in-ashkenazi-women-carriers-of-founder-brca1-2-mutations-beyond-10%C3%A2-years-of-follow-up
#6
E Dagan, R Gershoni-Baruch, A Kurolap, G Fried
This study uncovers disease characteristics by long-term follow-up in Ashkenazi early onset breast cancer (EOBC) patients, carriers of founder BRCA1/2 mutations compared to non-carriers of such mutations. An archives-retrospective design was conducted to study the pathological and clinical characteristics of 149 Ashkenazi Jewish EOBC patients (<42 years) who were referred consecutively to the oncogenetic clinic by the oncology centre at Rambam HealthCare Campus, as from 1995, with a mean follow-up of 13...
October 10, 2016: European Journal of Cancer Care
https://www.readbyqxmd.com/read/27642480/-lynch-syndrome-case-report-and-review-of-the-literature
#7
Laila Bouguenouch, Imane Samri, Khadija Belhassan, Hanane Sayel, Meriame Abbassi, Sanae Bennis, Dafr Allah Benajah, Adil Ibrahimi, Afaf Amarti, Karim Ouldim
Lynch syndrome or hereditary nonpolyposis colorectal cancer (HNPCC) is the most common form of hereditary colorectal cancers. It increases cancer susceptibility, the risk of colorectal cancer in first-degree, endometrial cancer in women, and to a lesser extent, other cancers (ovarian, small bowel, stomach, urinary tract and hepatobiliary). Thus, the cumulative risk of developing colorectal cancer or endometrial cancer at the age of 80 years rises to 20 and 40% respectively. These cancers are characterized by a positive family history, their occurrence at an early age, and by the development of metachronous cancers in the same individual...
2016: Pan African Medical Journal
https://www.readbyqxmd.com/read/27553278/selective-killing-of-cancer-cells-by-small-molecules-targeting-heat-shock-stress-response
#8
Daniel Zhang, Bin Zhang
HSF1 heat shock response has emerged as a valuable non-oncogenetic intervention point in targeted cancer therapy. Current reporter based high throughput screening has led to the discovery of several compounds or chemotypes that are effective in the growth inhibition of multiple cancer cell lines and relevant animal tumor models. However, some intrinsic limitations of reporter based assays can potentially lead to biased results. Using a previously validated high content image based assay, we performed a phenotypic screen targeting HSF1 heat shock pathway with a chemically diversified library of over 100,000 compounds...
September 30, 2016: Biochemical and Biophysical Research Communications
https://www.readbyqxmd.com/read/27526040/design-and-synthesis-of-new-potent-ptp1b-inhibitors-with-the-skeleton-of-2-substituted-imino-3-substituted-5-heteroarylidene-1-3-thiazolidine-4-one-part-i
#9
Ge Meng, Meilin Zheng, Mei Wang, Jing Tong, Weijuan Ge, Jiehe Zhang, Aqun Zheng, Jingya Li, Lixin Gao, Jia Li
A new series of 2-substituted imino-3-substituted-5- heteroarylidene-1,3-thiazolidine-4-ones as the potent bidentate PTP1B inhibitors were designed and synthesized in this paper. All of the new compounds were characterized and identified by spectra analysis. The biological screening test against PTP1B showed that some of these compounds have the positive inhibitory activity against PTP1B. The activity of the compounds with 5-substituted pyrrole on 5-postion of 1,3-thiazolidine-4-one are more potent than that of those compounds with 5-substituted pyridine group...
October 21, 2016: European Journal of Medicinal Chemistry
https://www.readbyqxmd.com/read/27500490/zeb1-drives-epithelial-to-mesenchymal-transition-in-lung-cancer
#10
Jill E Larsen, Vaishnavi Nathan, Jihan K Osborne, Rebecca K Farrow, Dhruba Deb, James P Sullivan, Patrick D Dospoy, Alexander Augustyn, Suzie K Hight, Mitsuo Sato, Luc Girard, Carmen Behrens, Ignacio I Wistuba, Adi F Gazdar, Nicholas K Hayward, John D Minna
Increased expression of zinc finger E-box binding homeobox 1 (ZEB1) is associated with tumor grade and metastasis in lung cancer, likely due to its role as a transcription factor in epithelial-to-mesenchymal transition (EMT). Here, we modeled malignant transformation in human bronchial epithelial cells (HBECs) and determined that EMT and ZEB1 expression are early, critical events in lung cancer pathogenesis. Specific oncogenic mutations in TP53 and KRAS were required for HBECs to engage EMT machinery in response to microenvironmental (serum/TGF-β) or oncogenetic (MYC) factors...
September 1, 2016: Journal of Clinical Investigation
https://www.readbyqxmd.com/read/27496341/long-noncoding-rna-hulc-promotes-colorectal-carcinoma-progression-through-epigenetically-repressing-nkd2-expression
#11
Xiao-Jun Yang, Chao-Qun Huang, Chun-Wei Peng, Jin-Xuan Hou, Jiu-Yang Liu
Recently, long noncoding RNAs (lncRNAs) have been emerged as crucial regulators of human diseases and prognostic markers in numerous of cancers, including colorectal carcinoma (CRC). Here, we identified an oncogenetic lncRNA HULC, which may promote colorectal tumorigenesis. HULC has been found to be up-regulated and acts as oncogene in gastric cancer and hepatocellular carcinoma, but its expression pattern, biological function and underlying mechanism in CRC is still undetermined. Here, we reported that HULC expression is also over-expressed in CRC, and its increased level is associated with poor prognosis and shorter survival...
October 30, 2016: Gene
https://www.readbyqxmd.com/read/27460090/long-noncoding-rna-bcar4-promotes-osteosarcoma-progression-through-activating-gli2-dependent-gene-transcription
#12
Fenyong Chen, Jiadong Mo, Li Zhang
Despite great advances have been made in the understanding of biology of osteosarcoma, the molecular mechanisms involved in osteosarcoma tumorigenesis and progression are still largely unknown. Long noncoding RNA (lncRNA) is a new type of RNA molecule, which plays pivotal roles in many tumors. lncRNA BCAR4 has been identified as an oncogenetic lncRNA involved in the progression of breast cancer. However, the functions and clinical significances of BCAR4 in osteosarcoma are unknown now. In this study, we found that BCAR4 was significantly upregulated in osteosarcoma tissues...
July 27, 2016: Tumour Biology: the Journal of the International Society for Oncodevelopmental Biology and Medicine
https://www.readbyqxmd.com/read/27457351/alcoholic-liver-disease-and-hepatitis-c-chronic-infection
#13
Alessandro Federico, Vittorio Maria Ormando, Marcello Dallio, Ludovico Abenavoli, Mario Masarone, Marcello Persico, Carmela Loguercio
Alcoholic and virus C hepatitis currently represent the main causes of chronic liver disease worldwide. Every year many people die and are subjected to complex hospitalization and medical assistance due to these pathologies. Alcoholic liver disease and hepatitis C virus chronic infection are often present in the same patient. These two pathologies sinergically act in determining the onset and progression of liver damage that, from the chronic hepatitis staging, may rapidly progress to fibrosis, cirrhosis and hepatocellular carcinoma...
July 23, 2016: Reviews on Recent Clinical Trials
https://www.readbyqxmd.com/read/27424422/-when-to-refer-patients-for-oncogenetic-counseling
#14
Valeria Viassolo, Pierre O Chappuis
Approximately 5 to 10% of all malignant tumors can be attributed to highly penetrant cancer predisposition genes. More than 100 of these genes have been identified. Taking into account the complexity and the various implications of predictive oncology, and in accordance with the current regulation, every constitutional molecular analysis must be performed within the framework of a genetic counseling. Besides the implementation of the next generation sequencing technology in clinical laboratory, family history remains a key information to identify hereditary cancer syndromes and to propose genetic counseling...
May 18, 2016: Revue Médicale Suisse
https://www.readbyqxmd.com/read/27345073/the-integration-of-brca-testing-into-oncology-clinics
#15
Natalie Percival, Angela George, Jennifer Gyertson, Monica Hamill, Andreia Fernandes, Emily Davies, Nazneen Rahman, Susana Banerjee
PURPOSE: The PARP inhibitor, Olaparib, is approved for women with BRCA-mutated ovarian cancer. Therefore there is an urgent need to test patients and obtain results in time to influence treatment. Models of BRCA testing, such as the mainstreaming oncogenetic pathway, involving oncology health professionals are being used. The authors report on the establishment of the extended role of the clinical nurse specialist in consenting women for BRCA testing in routine gynaecology-oncology clinics using the mainstreaming model...
June 23, 2016: British Journal of Nursing: BJN
https://www.readbyqxmd.com/read/27318168/women-at-high-risk-of-breast-cancer-molecular-characteristics-clinical-presentation-and-management
#16
REVIEW
Zdenek Kleibl, Vessela N Kristensen
The presence of breast cancer in any first-degree female relative in general nearly doubles the risk for a proband and the risk gradually increases with the number of affected relatives. Current advances in molecular oncology and oncogenetics may enable the identification of high-risk individuals with breast-cancer predisposition. The best-known forms of hereditary breast cancer (HBC) are caused by mutations in the high-penetrance genes BRCA1 and BRCA2. Other genes, including PTEN, TP53, STK11/LKB1, CDH1, PALB2, CHEK2, ATM, MRE11, RAD50, NBS1, BRIP1, FANCA, FANCC, FANCM, RAD51, RAD51B, RAD51C, RAD51D, and XRCC2 have been described as high- or moderate-penetrance breast cancer-susceptibility genes...
August 2016: Breast: Official Journal of the European Society of Mastology
https://www.readbyqxmd.com/read/27246976/long-noncoding-rna-zfas1-promotes-gastric-cancer-cells-proliferation-by-epigenetically-repressing-klf2-and-nkd2-expression
#17
Fengqi Nie, Xiang Yu, Mingde Huang, Yunfei Wang, Min Xie, Hongwei Ma, Zhaoxia Wang, Wei De, Ming Sun
Recently, long noncoding RNAs have been emerged as critical regulators of human disease and prognostic markers in several cancers, including gastric cancer. In this study, we globally assessed the transcriptomic differences of lncRNAs in gastric cancer using publicly available microarray data from Gene Expression Omnibus (GEO) and identified an oncogenetic lncRNA ZFAS1, which may promote gastric tumorigenesis. ZFAS1 has been found to be upregulated and function as oncogene in colorectal cancer and hepatocellular carcinoma, but its expression pattern, biological function and underlying mechanism in gastric cancer is still undetermined...
May 26, 2016: Oncotarget
https://www.readbyqxmd.com/read/27223487/early-onset-breast-cancer-patients-in-the-south-and-southeast-of-brazil-should-be-tested-for-the-tp53-p-r337h-mutation
#18
Kelvin C Andrade, Karina M Santiago, Fernanda P Fortes, Lisley I Mambelli, Amanda F Nóbrega, Maria I Achatz
Germline TP53 mutations are associated with Li-Fraumeni syndrome (LFS), a disease that predisposes carriers to a wide variety of early onset tumors. In southern and southeastern Brazil, a high frequency of a germline TP53 mutation, p.R337H, was diagnosed in 0,3% of the population due to a founder effect. Carriers are at risk for developing cancer but the penetrance is lower than in typical DNA binding domain mutations. To date, only a few families were detected and diagnosis of carriers remains a challenge...
May 24, 2016: Genetics and Molecular Biology
https://www.readbyqxmd.com/read/27192127/oncogenetics-service-and-the-brazilian-public-health-system-the-experience-of-a-reference-cancer-hospital
#19
Edenir I Palmero, Henrique C R Galvão, Gabriela C Fernandes, André E de Paula, Junea C Oliveira, Cristiano P Souza, Carlos E Andrade, Luis G C Romagnolo, Sahlua Volc, Maximiliano C Neto, Cristina Sabato, Rebeca Grasel, Edmundo Mauad, Rui M Reis, Rodrigo A D Michelli
The identification of families at-risk for hereditary cancer is extremely important due to the prevention potential in those families. However, the number of Brazilian genetic services providing oncogenetic care is extremely low for the continental dimension of the country and its population. Therefore, at-risk patients do not receive appropriate assistance. This report describes the creation, structure and management of a cancer genetics service in a reference center for cancer prevention and treatment, the Barretos Cancer Hospital (BCH)...
May 13, 2016: Genetics and Molecular Biology
https://www.readbyqxmd.com/read/27190992/the-occurrence-of-genetic-alterations-during-the-progression-of-breast-carcinoma
#20
Xiao-Chen Li, Chenglin Liu, Tao Huang, Yang Zhong
The interrelationship among genetic variations between the developing process of carcinoma and the order of occurrence has not been completely understood. Interpreting the mechanisms of copy number variation (CNV) is absolutely necessary for understanding the etiology of genetic disorders. Oncogenetic tree is a special phylogenetic tree inferential pictorial representation of oncogenesis. In our present study, we constructed oncogenetic tree to imitate the occurrence of genetic and cytogenetic alterations in human breast cancer...
2016: BioMed Research International
keyword
keyword
55744
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"