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https://www.readbyqxmd.com/read/28728206/-subaxial-cervical-spine-injuries-treatment-recommendations-of-the-german-orthopedic-and-trauma-society
#1
Philipp Schleicher, Matti Scholz, Frank Kandziora, Andreas Badke, Florian Hans Brakopp, Helmut Klaus Friedrich Ekkerlein, Erol Gercek, Rene Hartensuer, Philipp Hartung, Jan-Sven Gilbert Jarvers, Philipp Kobbe, Stefan Matschke, Robert Morrison, Christian W Müller, Miguel Pishnamaz, Maximilian Reinhold, Klaus John Schnake, Gregor Schmeiser, Gregor Stein, Bernhard Ullrich, Thomas Weiß, Volker Zimmermann
In a consensus process during four sessions in 2016, the working group "lower cervical spine" of the German Society for Orthopedic and Trauma Surgery (DGOU), formulated "Therapeutic Recommendations for the Lower Cervical Spine", taking into consideration the current literature. Therapeutic goals are a permanently stable, painless cervical spine and the protection against secondary neurologic damage while retaining the greatest possible amount of motion and spinal profile. Due to its ease of use and its proven good reliability, the AOSpine classification for subaxial cervical injuries should be used...
July 20, 2017: Zeitschrift Für Orthopädie und Unfallchirurgie
https://www.readbyqxmd.com/read/28727544/abbreviated-biparametric-prostate-mr-imaging-in-men-with-elevated-prostate-specific-antigen
#2
Christiane K Kuhl, Robin Bruhn, Nils Krämer, Sven Nebelung, Axel Heidenreich, Simone Schrading
Purpose To determine the diagnostic accuracy for clinically significant prostate cancer achieved with abbreviated biparametric prostate magnetic resonance (MR) imaging in comparison with full multiparametric contrast material-enhanced prostate MR imaging in men with elevated prostate-specific antigen (PSA) and negative transrectal ultrasonography (US)-guided biopsy findings; to determine the significant cancer detection rate of biparametric versus full multiparametric contrast-enhanced MR imaging and between-reader agreement for interpretation of biparametric MR imaging...
July 20, 2017: Radiology
https://www.readbyqxmd.com/read/28725584/magnetic-resonance-imaging-detection-of-prostate-cancer-in-men-with-previous-negative-prostate-biopsy
#3
REVIEW
Matthew Truong, Thomas P Frye
Use of transrectal ultrasound guided systematic prostate biopsy has poor diagnostic accuracy for prostate cancer (PCa) detection. Recently multiparametric MRI (mpMRI) of the prostate and MR/US fusion biopsy has been gaining popularity for men who have previously undergone a negative biopsy. We performed PubMed(®) and Web of Science(®) searches to identify studies on this subject, particularly focusing on studies consisting of patients who have had at least one previously negative biopsy. Across the literature, when a suspicious lesion is found on mpMRI, MR/US fusion biopsy has consistently demonstrated higher detection rate for any PCa and clinically significant PCa (csPCa) compared to the traditional repeat systematic biopsy (SB) approach...
June 2017: Translational Andrology and Urology
https://www.readbyqxmd.com/read/28723697/the-history-and-future-of-ablative-neurosurgery-for-major-depressive-disorder
#4
Matthew Volpini, Peter Giacobbe, G Rees Cosgrove, Anthony Levitt, Andres M Lozano, Nir Lipsman
BACKGROUND: There is an urgent need to develop safe and effective treatments for patients with treatment-resistant depression (TRD). Several neurosurgical procedures have been developed to treat the dysfunctional brain circuits implicated in major depression. OBJECTIVES: This review describes the most common ablative procedures used to treat major depressive disorder: anterior cingulotomy, subcaudate tractotomy, limbic leucotomy, and anterior capsulotomy. The efficacy and safety of each are discussed and compared with other current and emerging modalities, including deep brain stimulation (DBS) and MR-guided focused ultrasound (MRgFUS)...
July 20, 2017: Stereotactic and Functional Neurosurgery
https://www.readbyqxmd.com/read/28715967/hyperthermia-enhanced-targeted-drug-delivery-using-magnetic-resonance-guided-focussed-ultrasound-a-pre-clinical-study-in-a-genetic-model-of-pancreatic-cancer
#5
Navid Farr, Yak-Nam Wang, Samantha D'Andrea, Frank Starr, Ari Partanen, Kayla M Gravelle, Jeannine S McCune, Linda J Risler, Stella G Whang, Amy Chang, Sunil R Hingorani, Donghoon Lee, Joo Ha Hwang
PURPOSE: The lack of effective treatment options for pancreatic cancer has led to a 5-year survival rate of just 8%. Here, we evaluate the ability to enhance targeted drug delivery using mild hyperthermia in combination with the systemic administration of a low-temperature sensitive liposomal formulation of doxorubicin (LTSL-Dox) using a relevant model for pancreas cancer. MATERIALS AND METHODS: Experiments were performed in a genetically engineered mouse model of pancreatic cancer (KPC mice: LSL-Kras(G12D/+); LSL-Trp53(R172H/+); Pdx-1-Cre)...
July 17, 2017: International Journal of Hyperthermia
https://www.readbyqxmd.com/read/28714565/mri-compatible-breast-rib-phantom-for-evaluating-ultrasonic-thermal-exposures
#6
Georgios Menikou, Marinos Yiannakou, Christos Yiallouras, Cleanthis Ioannides, Christakis Damianou
INTRODUCTION: The target of this study was the development of a magnetic resonance imaging (MRI) compatible breast phantom for focused ultrasound which includes plastic (ABS) ribs. The objective of the current study was the evaluation of a focused ultrasound procedure using the proposed phantom that eliminates rib heating. MATERIAL AND METHODS: The proposed phantom was evaluated using two different focused ultrasound exposures. The surrounding breast tissue was mimicked using an agar-silica-evaporation milk gel (2% w/v - 2% w/v - 40% v/v)...
July 17, 2017: International Journal of Medical Robotics + Computer Assisted Surgery: MRCAS
https://www.readbyqxmd.com/read/28714454/a-back-projection-algorithm-in-the-presence-of-an-extra-attenuating-medium-towards-epid-dosimetry-for-the-mr-linac
#7
I Torres-Xirau, I Olaciregui-Ruiz, R A Rozendaal, P González, B J Mijnheer, J-J Sonke, U A van der Heide, A Mans
In external beam radiotherapy, electronic portal imaging devices (EPIDs) are frequently used for pre-treatment and for in vivo dose verification. Currently, various MR-guided radiotherapy systems are being developed and clinically implemented. Independent dosimetric verification is highly desirable. For this purpose we adapted our EPID-based dose verification system for use with the MR-Linac combination developed by Elekta in cooperation with UMC Utrecht and Philips. In this study we extended our back-projection method to cope with the presence of an extra attenuating medium between the patient and the EPID...
July 17, 2017: Physics in Medicine and Biology
https://www.readbyqxmd.com/read/28703340/core-satellite-polydopamine-gadolinium-metallofullerene-nanotheranostics-for-multimodal-imaging-guided-combination-cancer-therapy
#8
Sheng Wang, Jing Lin, Zhantong Wang, Zijian Zhou, Ruiliang Bai, Nan Lu, Yijing Liu, Xiao Fu, Orit Jacobson, Wenpei Fan, Junle Qu, Siping Chen, Tianfu Wang, Peng Huang, Xiaoyuan Chen
Integration of magnetic resonance imaging (MRI) and other imaging modalities is promising to furnish complementary information for accurate cancer diagnosis and imaging-guided therapy. However, most gadolinium (Gd)-chelator MR contrast agents are limited by their relatively low relaxivity and high risk of released-Gd-ions-associated toxicity. Herein, a radionuclide-(64) Cu-labeled doxorubicin-loaded polydopamine (PDA)-gadolinium-metallofullerene core-satellite nanotheranostic agent (denoted as CDPGM) is developed for MR/photoacoustic (PA)/positron emission tomography (PET) multimodal imaging-guided combination cancer therapy...
July 13, 2017: Advanced Materials
https://www.readbyqxmd.com/read/28692129/distortion-free-diffusion-mri-using-an-mri-guided-tri-cobalt-60-radiotherapy-system-sequence-verification-and-preliminary-clinical-experience
#9
Yu Gao, Fei Han, Ziwu Zhou, Minsong Cao, Tania Kaprealian, Mitchell Kamrava, Chenyang Wang, John Neylon, Daniel A Low, Yingli Yang, Peng Hu
PURPOSE: Monitoring tumor response during the course of treatment and adaptively modifying treatment plan based on tumor biological feedback may represent a new paradigm for radiotherapy. Diffusion MRI has shown great promises in assessing and predicting tumor response to radiotherapy. However, the conventional diffusion-weighted single-shot echo-planar-imaging (DW-ssEPI) technique suffers from limited resolution, severe distortion and possibly inaccurate ADC at low field strength. The purpose of this work is to develop a reliable, accurate and distortion-free diffusion MRI technique that is practicable for longitudinal tumor response evaluation and adaptive radiotherapy on a 0...
July 10, 2017: Medical Physics
https://www.readbyqxmd.com/read/28690121/assessment-of-factors-that-could-affect-the-success-of-us-guided-contrast-injection-for-hip-mr-arthrography
#10
Yi-Chih Hsu, Yu-Cheng Wu, Kai-Hsiung Ko, Hsian-He Hsu, Guo-Shu Huang
BACKGROUND: To retrospectively evaluate the association between possible influencing factors and failed first attempts to inject a contrast agent intra-articularly under ultrasound (US)-guidance for direct magnetic resonance (MR) arthrography of the hip joint. METHODS: Ninety consecutive patients (38 women and 52 men; mean age, 42 years) undergoing US-guided hip MR arthrography (3 bilaterally) were retrospectively included in this study. The potential influencing factors were sex, age, body mass index (BMI), side of injection, target site, trajectory of the needle, additional use of needle tip rotation, failed first-attempt, and capsule elongation at the site of needle insertion...
July 6, 2017: Journal of the Chinese Medical Association: JCMA
https://www.readbyqxmd.com/read/28687915/revised-propeller-for-t2-weighted-imaging-of-the-prostate-at-3-tesla-impact-on-lesion-detection-and-pi-rads-classification
#11
Michael Meier-Schroers, Christian Marx, Frederic Carsten Schmeel, Karsten Wolter, Jürgen Gieseke, Wolfgang Block, Alois Martin Sprinkart, Frank Traeber, Winfried Willinek, Hans Heinz Schild, Guido Matthias Kukuk
PURPOSE: To evaluate revised PROPELLER (RevPROP) for T2-weighted imaging (T2WI) of the prostate as a substitute for turbo spin echo (TSE). MATERIALS AND METHODS: Three-Tesla MR images of 50 patients with 55 cancer-suspicious lesions were prospectively evaluated. Findings were correlated with histopathology after MRI-guided biopsy. T2 RevPROP, T2 TSE, diffusion-weighted imaging, dynamic contrast enhancement, and MR-spectroscopy were acquired. RevPROP was compared to TSE concerning PI-RADS scores, lesion size, lesion signal-intensity, lesion contrast, artefacts, and image quality...
July 7, 2017: European Radiology
https://www.readbyqxmd.com/read/28685419/joint-deformable-liver-registration-and-bias-field-correction-for-mr-guided-hdr-brachytherapy
#12
Marko Rak, Tim König, Klaus D Tönnies, Mathias Walke, Jens Ricke, Christian Wybranski
PURPOSE: In interstitial high-dose rate brachytherapy, liver cancer is treated by internal radiation, requiring percutaneous placement of applicators within or close to the tumor. To maximize utility, the optimal applicator configuration is pre-planned on magnetic resonance images. The pre-planned configuration is then implemented via a magnetic resonance-guided intervention. Mapping the pre-planning information onto interventional data would reduce the radiologist's cognitive load during the intervention and could possibly minimize discrepancies between optimally pre-planned and actually placed applicators...
July 6, 2017: International Journal of Computer Assisted Radiology and Surgery
https://www.readbyqxmd.com/read/28675492/development-of-patient-controlled-respiratory-gating-system-based-on-visual-guidance-for-magnetic-resonance-image-guided-radiation-therapy
#13
Jung-In Kim, Hanyoung Lee, Hong-Gyun Wu, Eui Kyu Chie, Hyun-Cheol Kang, Jong Min Park
PURPOSE: The aim of this study is to develop a visual guidance patient-controlled (VG-PC) respiratory gating system for respiratory-gated magnetic-resonance image-guided radiation therapy (MR-IGRT) and to evaluate the performance of the developed system. METHODS: The near-real-time cine planar MR image of a patient acquired during treatment was transmitted to a beam projector in the treatment room through an optical fiber cable. The beam projector projected the cine MR images inside the bore of the ViewRay system in order to be visible to a patient during treatment...
July 4, 2017: Medical Physics
https://www.readbyqxmd.com/read/28673762/diffusion-weighted-mri-in-image-guided-adaptive-brachytherapy-tumor-delineation-feasibility-study-and-comparison-with-gec-estro-guidelines
#14
Antoine Schernberg, Corinne Balleyguier, Isabelle Dumas, Sébastien Gouy, Alexandre Escande, Enrica Bentivegna, Philippe Morice, Eric Deutsch, Christine Haie-Meder, Cyrus Chargari
PURPOSE: To examine the feasibility of using diffusion-weighted images (DWIs) coregistered with T2-weighted (T2w) sequence in treatment planning system to improve target delineation for image-guided adaptive brachytherapy (IGABT) in locally advanced cervical cancer patients. METHODS AND MATERIALS: We retrospectively examined the records of consecutive patients who were referred to our institution for pulse-dose-rate IGABT between May and December 2015 after concurrent chemoradiation...
June 30, 2017: Brachytherapy
https://www.readbyqxmd.com/read/28673657/image-guided-percutaneous-radiofrequency-ablation-of-central-renal-cell-carcinoma-assessment-of-clinical-efficacy-and-safety-in-31-tumors
#15
Ying Dai, Diego Covarrubias, Raul Uppot, Ronald S Arellano
PURPOSE: To assess clinical efficacy and safety of image-guided percutaneous radiofrequency (RF) ablation of central renal cell carcinoma with adjunctive pyeloperfusion. MATERIALS AND METHODS: Patients with central renal tumors who underwent percutaneous RF ablation between 2005 and 2010 were retrospectively evaluated. Thirty patients with 31 central renal tumors underwent 39 RF ablation sessions. Mean tumor diameter was 3.7 cm (range, 2-7 cm). Median distance between tumor and renal pelvis was 5 mm (range, 0-15 mm)...
July 1, 2017: Journal of Vascular and Interventional Radiology: JVIR
https://www.readbyqxmd.com/read/28673473/clinical-manifestations-and-imaging-tools-in-the-diagnosis-of-splanchnic-and-cerebral-vein-thromboses
#16
Nicoletta Riva, Walter Ageno
Splanchnic vein thrombosis (SVT) and cerebral vein thrombosis (CVT) are uncommon manifestation of venous thromboembolism (VTE), occurring less frequently than deep vein thrombosis of the lower extremities and pulmonary embolism. SVT encompasses portal vein thrombosis, mesenteric vein thrombosis, splenic vein thrombosis and the Budd-Chiari syndrome. It is therefore a heterogeneous disease, with differences in clinical manifestations according to the site of thrombosis. CVT includes thrombosis of the cortical or deep cerebral veins and thrombosis of the major dural venous sinuses...
June 27, 2017: Thrombosis Research
https://www.readbyqxmd.com/read/28668165/mr-imaging-in-gynecologic-brachytherapy
#17
REVIEW
Jessica B Robbins, Elizabeth A Sadowski, Shruti Jolly, Katherine E Maturen
Magnetic resonance-based image-guided adaptive brachytherapy is gaining popularity in the United States in the setting of gynecologic malignancies. This technique improves local control, increases overall survival, and minimizes toxicity to the adjacent organs at risk. The purpose of this article is to familiarize radiologists with image-guided adaptive brachytherapy by describing its history, detailing MR imaging techniques, describing treatment considerations, and reviewing image interpretation.
August 2017: Magnetic Resonance Imaging Clinics of North America
https://www.readbyqxmd.com/read/28668164/mr-imaging-of-cervical-cancer
#18
REVIEW
Krupa Patel-Lippmann, Jessica B Robbins, Lisa Barroilhet, Bethany Anderson, Elizabeth A Sadowski, James Boyum
Cervical cancer is a significant cause of morbidity and mortality worldwide despite advances in screening and prevention. Although cervical cancer remains clinically staged, the 2009 International Federation of Gynecology and Obstetrics committee has encouraged the use of advanced imaging modalities, including MR imaging, where available, to increase the accuracy of staging, guide treatment, and detect recurrence. Understanding the multiple roles of advanced imaging in the evaluation of cervical cancer will help radiologists provide an accurate and useful report to the referring clinicians...
August 2017: Magnetic Resonance Imaging Clinics of North America
https://www.readbyqxmd.com/read/28668163/from-staging-to-prognostication-achievements-and-challenges-of-mr%C3%A2-imaging-in-the-assessment-of-endometrial-cancer
#19
REVIEW
Stephanie Nougaret, Yulia Lakhman, Hebert Alberto Vargas, Pierre Emmanuel Colombo, Shinya Fujii, Caroline Reinhold, Evis Sala
Endometrial cancer is the most common gynecologic malignancy in the United States, with recent increasing incidence mostly owing to obesity. Preoperative MR imaging is essential to stratify patients according to their risk of recurrence and to guide surgical management. In the combination of T2-weighted imaging, diffusion-weighted imaging, and dynamic contrast enhancement, MR imaging provides a "one-stop shop" approach for patient-specific accurate staging including the evaluation of the depth of myometrial invasion, cervical stromal invasion, extrauterine extension, and lymph node status...
August 2017: Magnetic Resonance Imaging Clinics of North America
https://www.readbyqxmd.com/read/28667392/-multiparametric-mri-of-the-prostate-important-radiological-findings-for-urologists
#20
REVIEW
Heinz-Peter Schlemmer
CLINICAL/METHODICAL ISSUE: High prevalence of prostate cancer with multifocality and biological heterogeneity. Insufficient conventional urological diagnostics. Discrimination between significant and insignificant cancer needed. STANDARD DIAGNOSTIC METHODS: Digital rectal examination, prostate-specific antigen (PSA) serum level, systematic transrectal ultrasound (TRUS)-guided prostate biopsy. METHODICAL INNOVATIONS: Multiparametric magnetic resonance imaging (mpMRI) including T2-weighted (T2w), diffusion-weighted and dynamic contrast-enhanced MRI according to the prostate imaging reporting and data system (PIRADS), MR-targeted biopsy, most frequently MR/TRUS image fusion biopsy...
June 30, 2017: Der Radiologe
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